MCID: ALL010
MIFTS: 52

Allergic Contact Dermatitis malady

Skin, Immune categories

Summaries for Allergic Contact Dermatitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.

MalaCards: Allergic Contact Dermatitis, also known as dermatitis, allergic contact, is related to atopic dermatitis and urticaria. An important gene associated with Allergic Contact Dermatitis is LCE3C (late cornified envelope 3C), and among its related pathways are Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q and TGF-Beta Pathway. The drugs trimeprazine and methdilazine and the compounds rantes and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and lymph node.

Wikipedia:64 Allergic contact dermatitis (ACD) is a form of contact dermatitis that is the manifestation of an... more...

Aliases & Classifications for Allergic Contact Dermatitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Related Diseases for Allergic Contact Dermatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Allergic Contact Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis31.1CCL22, CCR4, CCL17, CCL27, DEFB4A, CXCR3
2urticaria30.7GZMB
3toxic epidermal necrolysis30.3GZMB
4atopy30.3CXCR3, CCL17, CCL22
5allergic asthma30.3CCR4, CCL17, GZMB
6asthma30.3CCL22, CCR4, CCL19, CCL17, GZMB, DEFB4A
7occupational dermatitis11.1
8erythema multiforme10.6
9allergic urticaria10.5
10paronychia10.4
11allergic contact dermatitis of eyelid10.4
12rosacea10.4
13spongiotic dermatitis10.4
14pemphigus10.4
15angioedema10.4
16paresthesia10.4
17acute generalized exanthematous pustulosis10.4
18melkersson-rosenthal syndrome10.2
19telogen effluvium10.2
20pityriasis rosea10.2
21lymphangitis10.2
22tuberculoid leprosy10.2
23lichen planus10.2
24lichen nitidus10.2
25ochronosis10.2
26n syndrome10.2
27granuloma annulare10.2
28contact blepharoconjunctivitis10.2
29alopecia10.2
30alopecia areata10.2
31blepharoconjunctivitis10.2
32thymoma10.2
33autoimmune progesterone dermatitis10.2
34exfoliative dermatitis10.2
35exogenous ochronosis10.2
36pemphigus foliaceus10.2
37chronic actinic dermatitis10.2
38discoid lupus erythematosus10.2
39pemphigus erythematosus10.2
40stevens-johnson syndrome10.0GZMB
41bronchiolitis obliterans10.0CXCR3
42hepatitis b10.0GZMB, CCL27
43hepatitis10.0GZMB, CCL27
44myositis10.0GZMB
45arthritis10.0GZMB, LIF, CXCR3
46paragonimiasis10.0CCL17
47allergic rhinitis10.0CXCR3, CCL17, CCR4
48intermediate uveitis10.0CXCR3, CCR4
49osteoarthritis10.0CXCR3, LIF, DEFB4A
50sjogren's syndrome10.0CCL21, CCL27, GZMB, CXCR3

Graphical network of the top 20 diseases related to Allergic Contact Dermatitis:



Diseases related to allergic contact dermatitis

Clinical Features for Allergic Contact Dermatitis

Drugs & Therapeutics for Allergic Contact Dermatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Allergic Contact Dermatitis

Drug clinical trials:

Search ClinicalTrials for Allergic Contact Dermatitis

Search NIH Clinical Center for Allergic Contact Dermatitis

Search CenterWatch for Allergic Contact Dermatitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Allergic Contact Dermatitis

Anatomical Context for Allergic Contact Dermatitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Allergic Contact Dermatitis:

33
Skin, Tongue, Lymph node, Lung, Whole blood, Thyroid, Monocytes, Nk cells, T cells, B cells, Endothelial, Pituitary

Animal Models for Allergic Contact Dermatitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Allergic Contact Dermatitis

Sources:
51PubMed
See all sources

Articles related to Allergic Contact Dermatitis:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Contact dermatitis: Allergic and irritant. (24314385)
2014
2
Allergic contact dermatitis from ethylhexylglycerin in sunscreens. (24407069)
2014
3
Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model. (23499868)
2013
4
Allergic contact dermatitis caused by Helichrysum italicum contained in an emollient cream. (23782363)
2013
5
Rifamycin-associated postoperative allergic contact dermatitis in a 70-year-old patient. (23964560)
2013
6
Allergic contact dermatitis to cotoneaster species. (23289882)
2013
7
Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors. (23889474)
2013
8
Allergic contact dermatitis caused by methyl aminolevulinate. (22901839)
2013
9
Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. (22568849)
2012
10
Human skin safety test of green tea cell extracts in condition of allergic contact dermatitis. (24278598)
2012
11
Allergic contact dermatitis to colophonium in a sanitary pad-an overlooked allergen? (22320672)
2012
12
Occupational allergic contact dermatitis caused by eyelash extension glues. (23039004)
2012
13
Allergic contact dermatitis caused by methylisothiazolinone from a 'waist reduction belt'. (22568846)
2012
14
Allergic contact dermatitis caused by sodium metabisulfite: a challenging allergen: a case series and literature review. (23039002)
2012
15
Allergic contact dermatitis caused by C30-38 olefin/isopropyl maleate/MA copolymer in cosmetics. (23039010)
2012
16
Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. (22523067)
2012
17
Allergic contact dermatitis caused by a skin-lightening agent, 5,5'-dipropylbiphenyl-2,2'-diol. A comment. (22568852)
2012
18
Participation of complement 3a receptor (C3aR) in the sensitization phase of Th2 mediated allergic contact dermatitis. (22151392)
2012
19
A case of occupational airborne allergic contact dermatitis caused by faveira amargosa, a tropical timber. (22568844)
2012
20
Allergic contact dermatitis caused by isocyanates in resin jewellery. (22681468)
2012
21
Allergic contact dermatitis following ocular use of corticosteroids. (21265627)
2011
22
Contact dermatitis caused by chlorothalonil on imported roses: irritant or allergic reaction? (21658059)
2011
23
Time-dependent modulation of serotonin and its receptors 1A and 2A expression in allergic contact dermatitis. (21214634)
2011
24
Occupational allergic contact dermatitis of the ears caused by thiurams in a headset. (21906074)
2011
25
Allergic contact dermatitis caused by iodophor-impregnated surgical incise drape. (21985088)
2011
26
Unusual localization of allergic contact dermatitis from p-phenylenediamine. (22653013)
2011
27
Integrating chemistry and immunology in allergic contact dermatitis: more questions than answers? (21673709)
2011
28
Review of allergic and photoallergic contact dermatitis from an ingredient in a medicament vehicle consisting of a compress, poultice, plaster, and tape. (21603165)
2011
29
Safety assessment of allergic contact dermatitis hazards: an analysis supporting reduced animal use for the murine local lymph node assay. (20974208)
2011
30
Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis. (22022165)
2011
31
Allergic contact dermatitis caused by Salvia officinalis extract. (21392032)
2011
32
Upper-ear eczema: an unusual case of allergic contact dermatitis due to rubber additives. (21865113)
2011
33
Vitamin E and allergic contact dermatitis. (20487657)
2010
34
Occupational allergic contact dermatitis caused by basil (Ocimum basilicum). (21070226)
2010
35
Allergic contact dermatitis to inhalation corticosteroids. (19825528)
2010
36
Occupational allergic contact dermatitis due to thioureas. (20137733)
2010
37
Allergic contact dermatitis due to the beta-blocker betaxolol in eyedrops, with cross-sensitivity to timolol. (20536484)
2010
38
Allergic contact dermatitis to Elidel cream itself? (20690943)
2010
39
Hand dermatitis: a focus on allergic contact dermatitis to biocides. (19580920)
2009
40
Bullous allergic contact dermatitis to lidocaine. (19878248)
2009
41
A case of allergic contact dermatitis caused by glucan oligosaccharide. (19489973)
2009
42
Allergic contact dermatitis from dichlorobenzyl alcohol in a patient with multiple contact allergies. (19397627)
2009
43
Allergic contact dermatitis to phytantriol. (18844705)
2008
44
Cheilitis granulomatosa associated with allergic contact dermatitis to betel quid. (18353040)
2008
45
Allergic contact dermatitis to nickel: modified in vitro test protocols for better detection of allergen-specific response. (17244072)
2007
46
Occlusive irritant dermatitis: when is "allergic" contact dermatitis not allergic? (17366682)
2007
47
Erythema multiforme-like generalized allergic contact dermatitis caused by Alpinia galanga. (16487286)
2006
48
Occupational allergic contact dermatitis and blepharoconjunctivitis caused by gold. (9504245)
1998
49
Allergic contact dermatitis prevalence in patients with otitis externa. (1675529)
1991
50
Expression of intercellular adhesion molecule-1 in murine allergic contact dermatitis. (1983170)
1990

Genetic Variations for Allergic Contact Dermatitis

Expression for genes affiliated with Allergic Contact Dermatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Allergic Contact Dermatitis

Search GEO for disease gene expression data for Allergic Contact Dermatitis.

Pathways for genes affiliated with Allergic Contact Dermatitis

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 30KEGG
See all sources

Pathways related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3CXCR3, CCR10, CCR4
2
Hide members
10.2CCL22, CCL19, CCL21, CCL17, CCL27
3
Hide members
10.1CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
4
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
5
Hide members
10.0LIF, CCL27, CCL17, CCL21, CCL19, CCR4
6
Hide members
10.0CCL22, CXCR3, LIF, CCL27, CCL17, CCL21
7
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
8
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
910.0CXCR3, CCL22, CCR4, CCL19, CCL21, CCL17
10
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
11
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27

Compounds for genes affiliated with Allergic Contact Dermatitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1rantes4510.6CXCR3, LIF, DEFB4A, GZMB
2pge24510.6CCL27, CCL19
3mip-3beta4510.6CCL21, CCL19
4teck4510.6CCL19, CCR4, CCL21
5[alcl]4510.6CCR4, CCL17, GZMB
6il 104510.6CXCR3, CCL17, LIF
7tacrolimus45 50 1112.5CCL22, CXCR3, CCL17, GZMB
8larc4510.5CXCR3, CCL21, CCR4, CCL22, CCL17, CCL19
9allergens4510.5CCL17, CCL27, CXCR3
10hbd24510.5DEFB4A, PI3
11ccl445 2911.5CCL17, CCL21, CCL22, CCR4, CXCR3, CCL27
12histamine45 29 2412.5DEFB4A, CCL22, PI3, IL31, CXCR3, CD160
13cyclosporin a45 29 6012.5CCL17, CD160, LIF, PI3, GZMB, CCL22
14sb 20358045 6011.4LIF, DEFB4A, PI3, CCL22
15tarc4510.4CCL22, CCL17, CCL19, CCR4, CCL27, CCL21
16ccl345 2911.4CCL19, CCL22, CCR4, CCL21, CXCR3, CCL27
17superoxide45 2411.4PI3, LIF, CD160, CXCR3, GZMB
18dexamethasone45 50 29 1113.4LIF, DEFB4A, CCL27, CXCR3, CCL17, CCL22
19flagellin45 2911.4DEFB4A, CXCR3
20steroid4510.3GZMB, DEFB4A, LIF, PI3, CXCR3
21paraffin4510.2LIF, DEFB4A, CCR4, GZMB
22calcium45 50 11 2413.1CCL17, CCL22, CCR4, CXCR3, CD160, LIF
23tyrosine4510.1PI3, CXCR3, CD160, LIF, DEFB4A, CCR4
24lipid459.9LIF, CCR4, CCL27, GZMB, PI3, DEFB4A

GO Terms for genes affiliated with Allergic Contact Dermatitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1CCL22, CCL19, CCL21, CCL17, CCL27, DEFB4A
2extracellular spaceGO:0056159.6CCL22, CCL19, CCL21, CCL17, CCL27, LIF

Biological processes related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycoprotein biosynthetic processGO:01056010.6CCL21, CCL19
2immunological synapse formationGO:00177110.6CCL19, CCL21
3negative regulation of leukocyte apoptotic processGO:200010710.6CCL19, CCL21
4establishment of T cell polarityGO:00176810.6CCL21, CCL19
5response to prostaglandin E stimulusGO:03469510.6CCL19, CCL21
6positive regulation of dendritic cell antigen processing and presentationGO:00260610.5CCL19, CCL21
7positive regulation of chemotaxisGO:05092110.5CCL19, CCL21
8positive regulation of cell motilityGO:200014710.5CCL21, CCL19
9chemotaxisGO:00693510.4CCL17, CCL22, CCR4, CCL27, CCR10, DEFB4A
10positive regulation of receptor-mediated endocytosisGO:04826010.4CCL19, CCL21
11positive regulation of neutrophil chemotaxisGO:09002310.4CCL21, CCL19
12cell-cell signalingGO:00726710.3CCL22, CCL21, CCL17, CCL27
13inflammatory responseGO:00695410.3CCL19, CCL22, CCR4, CCL21, IL17F, CCL17
14immune responseGO:00695510.3CCL19, CCL27, LIF, DEFB4A, CCR10, CCR4
15elevation of cytosolic calcium ion concentrationGO:00720410.2CXCR3, CCR10, CCR4
16dendritic cell chemotaxisGO:00240710.1CCL21, CCL19

Molecular functions related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.4CCR4, CXCR3
2CCR7 chemokine receptor bindingGO:03173210.4CCL21, CCL19
3chemokine activityGO:00800910.3CCL17, CCL22, CCL19, CCL21, CCL27
4cytokine activityGO:00512510.2LIF, IL31, IL17D, IL17F
5C-C chemokine receptor activityGO:01649310.1CCR10, CCR4

Products for genes affiliated with Allergic Contact Dermatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Contact Dermatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet