MCID: ALL010
MIFTS: 58

Allergic Contact Dermatitis malady

Skin diseases, Immune diseases categories

Summaries for Allergic Contact Dermatitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.

MalaCards: Allergic Contact Dermatitis, also known as dermatitis, allergic contact, is related to contact dermatitis and dermatitis. An important gene associated with Allergic Contact Dermatitis is LCE3C (late cornified envelope 3C), and among its related pathways are Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q and TGF-Beta Pathway. The drugs trimeprazine and methdilazine and the compounds rantes and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells.

Wikipedia:63 Allergic contact dermatitis (ACD) is a form of contact dermatitis that is the manifestation of an... more...

Aliases & Classifications for Allergic Contact Dermatitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Allergic Contact Dermatitis

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17GeneCards, 18GeneDecks
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Diseases related to Allergic Contact Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1contact dermatitis32.3CCR4, CXCR3
2dermatitis32.3CCL22, CCR4, CCL17, CCL27, CCR10, GZMB
3atopic dermatitis31.0CCR4, CCL22, IL17D, CCL17, CCL27, DEFB4A
4psoriasis30.9IL17D, LCE3C, LCE3B, IL31, CXCR3, DEFB4A
5urticaria30.5GZMB
6cutaneous t cell lymphoma30.3CXCR3, GZMB, CCL17, CCR4, CCR10
7melanoma30.3CCR10, IL31, CXCR3, GZMB, CCR4, CCL21
8skin disease30.3CCL17, IL17D, IL31, CXCR3, DEFB4A, PI3
9allergic asthma30.3GZMB, CCR4, CCL17
10asthma30.2IL17F, GZMB, CCL17, CCL19, CCR4, CCL22
11occupational dermatitis11.1
12irritant dermatitis10.7
13erythema multiforme10.6
14cheilitis10.4
15paronychia10.3
16allergic contact dermatitis of eyelid10.3
17rosacea10.3
18spongiotic dermatitis10.3
19pemphigus10.3
20allergic urticaria10.3
21angioedema10.3
22otitis externa10.3
23scabies10.3
24wrinkles10.2
25melkersson-rosenthal syndrome10.2
26autoimmune thyroiditis10.2
27telogen effluvium10.2
28pityriasis rosea10.2
29multiple chemical sensitivity10.2
30choroiditis10.2
31mammary paget's disease10.2
32lymphangitis10.2
33tuberculoid leprosy10.2
34lichen planus10.2
35lichen nitidus10.2
36ochronosis10.2
37granuloma annulare10.2
38contact blepharoconjunctivitis10.2
39alopecia10.2
40alopecia areata10.2
41blepharoconjunctivitis10.2
42exanthem10.2
43glaucoma10.2
44leprosy10.2
45lupus erythematosus10.2
46panniculitis10.2
47t cell deficiency10.2
48thymoma10.2
49thyroiditis10.2
50vaginitis10.2

Graphical network of the top 20 diseases related to Allergic Contact Dermatitis:



Diseases related to allergic contact dermatitis

Clinical Features for Allergic Contact Dermatitis

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Drugs & Therapeutics for Allergic Contact Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Allergic Contact Dermatitis

Drug clinical trials:

Search ClinicalTrials for Allergic Contact Dermatitis

Search NIH Clinical Center for Allergic Contact Dermatitis

Search CenterWatch for Allergic Contact Dermatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Allergic Contact Dermatitis

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Anatomical Context for Allergic Contact Dermatitis

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32MalaCards
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MalaCards organs/tissues related to Allergic Contact Dermatitis:

32
Skin, Testes, T cells, Eye, Monocytes, Pituitary, Endothelial, Thyroid, Lung, Lymph node, Tongue, Bone, Nk cells

Animal Models for Allergic Contact Dermatitis or affiliated genes

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Publications for Allergic Contact Dermatitis

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50PubMed
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Articles related to Allergic Contact Dermatitis:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. (23149289)
2013
2
Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis by regulating the balance between inflammatory and anti-inflammatory cytokines. (24096935)
2013
3
An overview of parabens and allergic contact dermatitis. (24305662)
2013
4
Occupational allergic contact dermatitis caused by sterile non-latex protective gloves: clinical investigation and chemical analyses. (23206313)
2013
5
Allergic contact dermatitis caused by octocrylene in a young child. (22957488)
2012
6
Allergic contact dermatitis at the epidural catheter site due to MastisolAr liquid skin adhesive. (22653839)
2012
7
Sesquiterpene lactone mix as a diagnostic tool for Asteraceae allergic contact dermatitis: chemical explanation for its poor performance and Sesquiterpene lactone mix II as a proposed improvement. (22486565)
2012
8
Targeted testing with diethylthiourea often reveals clinically relevant allergic contact dermatitis caused by neoprene rubber. (22428567)
2012
9
Allergic contact dermatitis mimicking angioedema due to paraphenylendiamine hypersensitivity: a case report. (22181557)
2012
10
Toxic epidermal necrolysis following allergic contact dermatitis caused by occupational exposure to ultraviolet-cured inks. (22101957)
2012
11
Comparative study of systemic inflammatory responses in psoriasis vulgaris and mild to moderate allergic contact dermatitis. (22890310)
2012
12
Allergic contact dermatitis with contact urticaria to colophony from an alternative remedy. (23169218)
2012
13
Facial allergic contact dermatitis caused by fragrance ingredients released by an electric shaver. (23151195)
2012
14
Connubial allergic contact dermatitis caused by fragrance ingredients. (22653075)
2012
15
Systemic allergic contact dermatitis to black cumin essential oil expressing as generalized erythema multiforme. (21524993)
2011
16
Allergic contact dermatitis: a case series and review for the ophthalmologist. (20962285)
2011
17
Allergic contact dermatitis in health care workers to diazolidinyl urea present in antimicrobial hand gel. (21692731)
2011
18
A half of schoolchildren with 'ISAAC eczema' are ill with allergic contact dermatitis. (21134222)
2011
19
Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones. (21564130)
2011
20
Recurrent infections in children with nickel allergic contact dermatitis. (22217998)
2011
21
Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. (21599706)
2011
22
A case of occupational allergic contact dermatitis in a plumber performing pipeline repair. (21906077)
2011
23
Acute onset of generalized pruritic rash in a toddler. Diagnosis: systemic allergic (contact) dermatitis to nickel from ingestion of metal coins. (21276052)
2011
24
Occupational airborne allergic contact dermatitis caused by gold. (20920416)
2010
25
Allergic contact dermatitis due to cosmetics containing vitamin K1 oxide. (20433446)
2010
26
Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis. (20144742)
2010
27
Allergic contact dermatitis from ethylhexyl salicylate and other salicylates. (20233542)
2010
28
Clinico-allergological pattern of allergic contact dermatitis among 70 Indian children. (20061729)
2010
29
Allergic contact dermatitis: patch testing results at Mount Sinai Medical Center. (21137633)
2010
30
Allergic contact dermatitis due to a PVC table cover. (20844058)
2010
31
Allergic contact dermatitis: novel mechanisms and therapeutic perspectives. (20406191)
2010
32
Allergic contact dermatitis from timolol complicating choroidal melanoma-related glaucoma. (19171534)
2009
33
Aquatic antagonists: indirect nematocyst envenomation and acute allergic contact dermatitis due to nudibranchs. (19537280)
2009
34
Expression of COUP-TF-interacting protein 2 (CTIP2) in human atopic dermatitis and allergic contact dermatitis skin. (19366371)
2009
35
Patch testing in allergic contact dermatitis. (19138454)
2009
36
Allergic contact dermatitis to polyethylene terephthalate mesh. (19476023)
2009
37
Occupational allergic contact dermatitis due to dimethyl sulfate following sensitization from a severe acute irritant reaction to the reagent. (19260926)
2009
38
Mechanistic proposal for the formation of specific immunogenic complexes via a radical pathway: a key step in allergic contact dermatitis to olefinic hydroperoxides. (19725554)
2009
39
Three cases of allergic contact dermatitis to 4,4'-diaminodiphenylmethane. (19489974)
2009
40
Severe allergic contact dermatitis resulting from occupational exposure to tincture of benzoin aerosol spray in an anesthesiologist. (19444575)
2009
41
Allergic contact dermatitis induced by topical hydrocortisone butyrate propionate mimicking acute generalized exanthematous pustulosis. (19527994)
2009
42
Airborne allergic contact dermatitis due to budesonide from professional exposure. (18976387)
2008
43
A case of allergic contact dermatitis to clavulanic acid. (19076895)
2008
44
Anogenital allergic contact dermatitis, the role of spices and flavour allergy. (18844699)
2008
45
Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with allergic contact dermatitis. (17651310)
2007
46
Expression of CS-1 fibronectin precedes monocyte chemoattractant protein-1 production during elicitation of allergic contact dermatitis. (12911787)
2003
47
Multiple chemical sensitivities, including iatrogenic allergic contact dermatitis, in a patient with chronic actinic dermatitis: implications for management. (8957333)
1996
48
Changes in epidermal proliferation and differentiation in allergic and irritant contact dermatitis reactions. (7547390)
1995
49
Allergic airborne contact dermatitis to Compositae with photosensitivity--chronic actinic dermatitis in evolution. (2371171)
1990
50
Allergic contact dermatitis from a new dentin adhesive system]. (2151486)
1990

Genetic Variations for Allergic Contact Dermatitis

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Expression for genes affiliated with Allergic Contact Dermatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Contact Dermatitis

Search GEO for disease gene expression data for Allergic Contact Dermatitis.

Pathways for genes affiliated with Allergic Contact Dermatitis

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG
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Pathways related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.3CXCR3, CCR10, CCR4
2
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10.2CCL22, CCL19, CCL21, CCL17, CCL27
3
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10.1CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
4
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10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
5
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10.0LIF, CCL27, CCL17, CCL21, CCL19, CCR4
6
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10.0CCL22, CXCR3, LIF, CCL27, CCL17, CCL21
7
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
8
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
910.0CXCR3, CCL22, CCR4, CCL19, CCL21, CCL17
10
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
11
Hide members
10.0CCL22, CCR4, CCL19, CCL21, CCL17, CCL27

Compounds for genes affiliated with Allergic Contact Dermatitis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1rantes4410.6CXCR3, LIF, DEFB4A, GZMB
2pge24410.6CCL27, CCL19
3mip-3beta4410.6CCL21, CCL19
4teck4410.6CCL19, CCR4, CCL21
5[alcl]4410.6CCR4, CCL17, GZMB
6il 104410.6CXCR3, CCL17, LIF
7tacrolimus44 49 1112.5CCL22, CXCR3, CCL17, GZMB
8larc4410.5CXCR3, CCL21, CCR4, CCL22, CCL17, CCL19
9allergens4410.5CCL17, CCL27, CXCR3
10hbd24410.5DEFB4A, PI3
11ccl444 2811.5CCL17, CCL21, CCL22, CCR4, CXCR3, CCL27
12histamine44 28 2412.5DEFB4A, CCL22, PI3, IL31, CXCR3, CD160
13cyclosporin a44 28 5912.5CCL17, CD160, LIF, PI3, GZMB, CCL22
14sb 20358044 5911.4LIF, DEFB4A, PI3, CCL22
15tarc4410.4CCL22, CCL17, CCL19, CCR4, CCL27, CCL21
16ccl344 2811.4CCL19, CCL22, CCR4, CCL21, CXCR3, CCL27
17superoxide44 2411.4PI3, LIF, CD160, CXCR3, GZMB
18dexamethasone44 49 28 1113.4LIF, DEFB4A, CCL27, CXCR3, CCL17, CCL22
19flagellin44 2811.4DEFB4A, CXCR3
20steroid4410.3GZMB, DEFB4A, LIF, PI3, CXCR3
21paraffin4410.2LIF, DEFB4A, CCR4, GZMB
22calcium44 49 11 2413.1CCL17, CCL22, CCR4, CXCR3, CD160, LIF
23tyrosine4410.1PI3, CXCR3, CD160, LIF, DEFB4A, CCR4
24lipid449.9LIF, CCR4, CCL27, GZMB, PI3, DEFB4A

GO Terms for genes affiliated with Allergic Contact Dermatitis

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16Gene Ontology
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Cellular components related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1CCL22, CCL19, CCL21, CCL17, CCL27, DEFB4A
2extracellular spaceGO:0056159.6CCL22, CCL19, CCL21, CCL17, CCL27, LIF

Biological processes related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycoprotein biosynthetic processGO:01056010.6CCL21, CCL19
2immunological synapse formationGO:00177110.6CCL19, CCL21
3negative regulation of leukocyte apoptotic processGO:200010710.6CCL19, CCL21
4establishment of T cell polarityGO:00176810.6CCL21, CCL19
5response to prostaglandin E stimulusGO:03469510.6CCL19, CCL21
6positive regulation of dendritic cell antigen processing and presentationGO:00260610.5CCL19, CCL21
7positive regulation of chemotaxisGO:05092110.5CCL19, CCL21
8positive regulation of cell motilityGO:200014710.5CCL21, CCL19
9chemotaxisGO:00693510.4CCL17, CCL22, CCR4, CCL27, CCR10, DEFB4A
10positive regulation of receptor-mediated endocytosisGO:04826010.4CCL19, CCL21
11positive regulation of neutrophil chemotaxisGO:09002310.4CCL21, CCL19
12cell-cell signalingGO:00726710.3CCL22, CCL21, CCL17, CCL27
13inflammatory responseGO:00695410.3CCL19, CCL22, CCR4, CCL21, IL17F, CCL17
14immune responseGO:00695510.3CCL19, CCL27, LIF, DEFB4A, CCR10, CCR4
15elevation of cytosolic calcium ion concentrationGO:00720410.2CXCR3, CCR10, CCR4
16dendritic cell chemotaxisGO:00240710.1CCL21, CCL19

Molecular functions related to Allergic Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.4CCR4, CXCR3
2CCR7 chemokine receptor bindingGO:03173210.4CCL21, CCL19
3chemokine activityGO:00800910.3CCL17, CCL22, CCL19, CCL21, CCL27
4cytokine activityGO:00512510.2LIF, IL31, IL17D, IL17F
5C-C chemokine receptor activityGO:01649310.1CCR10, CCR4

Products for genes affiliated with Allergic Contact Dermatitis

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  • Antibodies
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Sources for Allergic Contact Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet