MCID: ALL010
MIFTS: 60

Allergic Contact Dermatitis

Categories: Skin diseases, Immune diseases

Aliases & Classifications for Allergic Contact Dermatitis

Summaries for Allergic Contact Dermatitis

PubMed Health : 59
About allergic contact dermatitis: A number of chemical or herbal substances can irritate the skin. Redness, burning or itching are normal skin reactions, for instance, to aggressive cleaning agents.Allergic contact dermatitis (sometimes simply called “contact allergies”) is different, though. Here the immune system overreacts to certain substances – sometimes to very small amounts – that normally wouldn’t cause a reaction. Common examples include certain metals, scents and latex rubber.Contact allergies can lead to severe skin reactions. Unlike with many other kinds of allergies, the reaction doesn’t occur immediately, but after one to three days. And contact allergies develop gradually over a long period of time, as a result of repeated contact with the substance that triggers them. Some people are then no longer able to carry on doing the same kind of work as before.

MalaCards based summary : Allergic Contact Dermatitis, also known as dermatitis, allergic contact, is related to dermatitis and erythema multiforme. An important gene associated with Allergic Contact Dermatitis is IL31 (Interleukin 31), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bacitracin and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.

Wikipedia : 72 Allergic contact dermatitis (ACD) is a form of contact dermatitis that is the manifestation of an... more...

Related Diseases for Allergic Contact Dermatitis

Diseases related to Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 364)
# Related Disease Score Top Affiliating Genes
1 dermatitis 30.7 CCL17 FLG IFNG IL17A IL31 IL4
2 erythema multiforme 30.5 CCL17 CXCR3 ICAM1 IFNG TNF
3 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.2 IFNG IL10 IL17A
4 choroiditis 30.2 IL10 TNF
5 irritant dermatitis 30.1 FLG IL1B TNF
6 acute generalized exanthematous pustulosis 29.9 CXCL8 IL17A
7 scabies 29.9 CXCL8 IL10
8 allergic hypersensitivity disease 29.9 CCL17 IFNG IL10 IL4 IL5
9 cutaneous t cell lymphoma 29.8 CCL17 IFNG IL4
10 discoid lupus erythematosus 29.8 FLG IL10 NAT2
11 actinic prurigo 29.7 ICAM1 IL1B SELE TNF
12 hashimoto thyroiditis 29.7 CXCR3 ICAM1 IFNG IL4
13 leprosy 3 29.7 IFNG IL10 IL4 TNF
14 alopecia areata 29.7 ICAM1 IFNG IL1B TNF
15 ige responsiveness, atopic 29.4 FLG IFNG IL10 IL4 IL5
16 lichen planus 29.0 CXCR3 FLG ICAM1 IFNG IL4 TNF
17 skin disease 28.2 CCL17 CXCL8 FLG IFNG IL10 IL4
18 contact dermatitis 27.5 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
19 dermatitis, atopic 27.0 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
20 psoriasis 26.7 CCL17 CXCL8 CXCR3 FLG ICAM1 IFNG
21 asthma 25.7 CCL17 CXCL8 FLG ICAM1 IFNG IL10
22 allergic contact dermatitis of eyelid 12.3
23 occupational dermatitis 11.6
24 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL5 TNF
25 punctate inner choroidopathy 10.5 IL10 TNF
26 heterophyiasis 10.5 ICAM1 SELE
27 eosinophilic fasciitis 10.5 IFNG IL5
28 autoimmune myocarditis 10.5 IFNG TNF
29 lymphocytic vasculitis 10.5 ICAM1 SELE
30 microscopic polyangiitis 10.4 IL10 TNF
31 multifocal choroiditis 10.4 IL10 TNF
32 chronic eosinophilic pneumonia 10.4 CXCR3 ICAM1 IL5
33 rheumatoid vasculitis 10.4 ICAM1 SELE TNF
34 critical illness polyneuropathy 10.4 ICAM1 SELE TNF
35 transient hypogammaglobulinemia 10.4 IL10 TNF
36 paragonimiasis 10.4 CCL17 CXCR3 IL5
37 primary progressive multiple sclerosis 10.3 ICAM1 IL10 TNF
38 chronic beryllium disease 10.3 IFNG TNF
39 rheumatoid lung disease 10.3 IL17A TNF
40 pustulosis of palm and sole 10.3
41 mycoplasmal pneumonia 10.3 IFNG IL4
42 african tick-bite fever 10.3 IFNG SELE
43 hemorrhagic fever 10.3 IFNG IL10 TNF
44 spotted fever 10.3 IFNG IL10 TNF
45 hematopoietic stem cell transplantation 10.3 IFNG IL10 TNF
46 neurosyphilis 10.3 IL10 IL17A
47 multicentric castleman disease 10.3 IFNG IL10 IL5
48 vasculitis 10.3 ICAM1 SELE TNF
49 polyposis, gastric 10.3 IL1B TNF
50 idiopathic achalasia 10.3 IL10 IL33 TNF

Graphical network of the top 20 diseases related to Allergic Contact Dermatitis:



Diseases related to Allergic Contact Dermatitis

Symptoms & Phenotypes for Allergic Contact Dermatitis

GenomeRNAi Phenotypes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 ICAM1 IL10 IL17A IL1B TNF CXCL8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 ICAM1 IL10 IL17A IL1B TNF CXCL8

MGI Mouse Phenotypes related to Allergic Contact Dermatitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 CXCR3 IL1B ICAM1 IL33 IFNG IL4
2 homeostasis/metabolism MP:0005376 10.1 IL17A CXCR3 IL1B ICAM1 IL33 IFNG
3 immune system MP:0005387 10.03 CXCR3 IL1B ICAM1 IL33 IFNG IL4
4 digestive/alimentary MP:0005381 10.01 ICAM1 IL33 IFNG IL4 IL10 IL5
5 integument MP:0010771 9.76 IL1B ICAM1 IL33 IFNG IL4 IL10
6 neoplasm MP:0002006 9.5 CXCR3 IL1B ICAM1 IFNG IL10 IL5
7 respiratory system MP:0005388 9.28 CXCR3 IL33 IFNG IL4 IL10 IL5

Drugs & Therapeutics for Allergic Contact Dermatitis

PubMedHealth treatment related to Allergic Contact Dermatitis: 59

Allergic skin reactions are usually treated with steroid creams, ointments or solutions.But the main thing to do is avoid contact with the substance that triggers the reaction. Protective gloves and clothing can help here, for instance.A change of career may have to be considered if it isn’t possible to avoid contact with the substance in the workplace. If you are believed to have a work-related contact allergy, it’s a good idea to have your doctor inform your employer’s liability insurance. The insurance will cover certain costs, like the costs of protective measures, if the allergy is recognized as being work-related.

Drugs for Allergic Contact Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bacitracin Approved, Vet_approved Phase 4,Phase 2 1405-87-4 10909430 439542
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
3 Parthenolide Approved, Investigational Phase 4,Phase 2 20554-84-1
4
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
5
Povidone Approved Phase 4 9003-39-8
6
Adapalene Approved Phase 4 106685-40-9 60164
7
Benzoyl peroxide Approved Phase 4 94-36-0 7187
8
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
9
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
10 Analgesics Phase 4,Phase 2
11 Analgesics, Non-Narcotic Phase 4,Phase 2
12 Anti-Bacterial Agents Phase 4,Phase 2
13 Antidotes Phase 4
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2
15 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
16 Anti-Inflammatory Agents Phase 4,Phase 2
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
18 Antioxidants Phase 4
19 Antirheumatic Agents Phase 4,Phase 2
20 Antitubercular Agents Phase 4
21 Bronopol Phase 4
22 Chelating Agents Phase 4
23 Cortisol succinate Phase 4
24 Dermatologic Agents Phase 4,Phase 3
25 Gold Sodium Thiosulfate Phase 4
26 Hydrocortisone 17-butyrate 21-propionate Phase 4
27 Hydrocortisone acetate Phase 4
28 Hydrocortisone-17-butyrate Phase 4
29 Peripheral Nervous System Agents Phase 4,Phase 2
30 Protective Agents Phase 4
31 sodium thiosulfate Phase 4
32 Calcineurin Inhibitors Phase 4
33 Immunosuppressive Agents Phase 4,Phase 2
34 Adapalene, Benzoyl Peroxide Drug Combination Phase 4
35 Clindamycin palmitate Phase 4
36 Clindamycin phosphate Phase 4
37
Petrolatum Approved, Investigational Phase 3 8009-03-8
38
Silver sulfadiazine Approved, Vet_approved Phase 3 22199-08-2 441244
39
Sulfadiazine Approved, Investigational, Vet_approved Phase 3 68-35-9 5215
40 Antiparasitic Agents Phase 3
41 Antiprotozoal Agents Phase 3
42 Emollients Phase 3
43 Antibodies Phase 3
44 Antibodies, Monoclonal Phase 3
45 Immunoglobulins Phase 3
46
Minoxidil Approved, Investigational Phase 1, Phase 2 38304-91-5 4201
47
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
48 Antihypertensive Agents Phase 1, Phase 2
49 Pharmaceutical Solutions Phase 1, Phase 2
50 Vasodilator Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 34)

# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
2 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
3 Study of the Safety and Efficacy of Tacrolimus Ointment in Treating Chronic Allergic Contact Dermatitis Completed NCT00667056 Phase 4 tacrolimus ointment;placebo ointment
4 Bioequivalence of Ethylenediamine Dihydrochloride Study Completed NCT01798589 Phase 4 Ethylenediamine dihydrochloride
5 A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne Completed NCT00887484 Phase 4 BENZOYL PEROXIDE/ CLINDAMYCIN;BENZOYL PEROXIDE/ ADAPALENE
6 A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne Completed NCT00964223 Phase 4 Clindamycin and benzoyl peroxide gel (Duac® Topical Gel);benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
7 Clinical Evaluation of T.R.U.E. TEST in Children and Adolescents Completed NCT00795951 Phase 4
8 A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine Completed NCT02109718 Phase 3 Open Dressings with Petrolatum Jelly;Silver Sulfadiazine Gauze Dressing Group
9 Anti-IL-17 a New Treatment for Contact Dermatititis Recruiting NCT02778711 Phase 3 secukinumab
10 Efficacy and Safety Comparing 5% Monoxidil Milky Lotion Versus 5% Minoxidil Solution in Androgenetic Alopecia Unknown status NCT01650272 Phase 1, Phase 2 5% MInoxidil milky lotion;5% Minoxidil solution
11 Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate Completed NCT00133341 Phase 2 Goldnatriomthiosulphate, MDBGN, parthenolide
12 Clinical Evaluation of Bacitracin Completed NCT00132600 Phase 2 bacitracin (allergen)
13 Study of the Intradermal Injection of rHuPH20 or Placebo in Subjects With Nickel Allergic Contact Dermatitis Completed NCT00928447 Phase 2 rHuPH20
14 Safety, Tolerability, and Efficacy of 21 Days Dermal Application of MRX-6 on Mild to Moderate Contact Dermatitis Completed NCT00867607 Phase 1, Phase 2 MRX-6;Steroid
15 Study of Apremilast in Atopic or Contact Dermatitis Completed NCT00931242 Phase 2 Apremilast
16 NI-0801 in Allergic Contact Dermatitis Completed NCT01244607 Phase 1 Placebo;NI-0801
17 CP-481,715 Nickel Allergy Study. Completed NCT00141180 Phase 1 CP-481,715
18 A Study of the Safety, Engraftment, and Action of NB01 in Adults With Moderate Acne Recruiting NCT03450369 Phase 1
19 Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation Unknown status NCT00445029
20 Nickel Desensitization Using Topical Therapy Unknown status NCT01413477 Calcipotriol, Betamethasone, Calcipotriol & Betamethasone
21 A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema Unknown status NCT01012453
22 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
23 Intervention Study to Evaluate the Importance of Information Given to Patients With Contact Allergy Completed NCT01953380
24 Evaluating for Contact Allergies in Patients With Chronic Urticaria Completed NCT00868036
25 Epidemiology and Co-Reactivity of Novel Surfactant Allergens Completed NCT02534441
26 Short Repeated Nickel Exposures Completed NCT03309215
27 Evaluation of Tetrix Cream in the Healing of Injured Skin in Subjects With Contact Dermatitis Completed NCT00643214
28 Cumulative Irritation Patch Test Completed NCT01842711
29 Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity Completed NCT02750735
30 Cutaneous and Systemic Reactions to Metal Implants Recruiting NCT02483728
31 Evaluating Results of Regularly Applied Emollient - Spray in Atopic Dermatitis Therapy Recruiting NCT02763722
32 Immune Reactions in Contact Dermatitis Affected Skin Enrolling by invitation NCT01546298
33 Low Dose Exposure to Oxidized R-limonene - A Repeated Open Application Test (ROAT) Study Enrolling by invitation NCT03313232
34 Improving Value of Care for Patients With Severe Stasis Dermatitis Not yet recruiting NCT03022786

Search NIH Clinical Center for Allergic Contact Dermatitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: dermatitis, allergic contact

Genetic Tests for Allergic Contact Dermatitis

Anatomical Context for Allergic Contact Dermatitis

MalaCards organs/tissues related to Allergic Contact Dermatitis:

38
Skin, Testes, T Cells, Bone, Eye, Monocytes, Tongue

Publications for Allergic Contact Dermatitis

Articles related to Allergic Contact Dermatitis:

(show top 50) (show all 728)
# Title Authors Year
1
Allergic contact dermatitis caused by hydroxyacetophenone in a face cream. ( 29341188 )
2018
2
Allergic contact dermatitis resulting from cetyl PEG/PPG-10/1 dimethicone in a deodorant cream. ( 29430705 )
2018
3
Kumkum-induced allergic contact dermatitis: Are we missing the actual culprit? ( 29393081 )
2018
4
First report of allergic contact dermatitis caused by sorbitan caprylate. ( 29341184 )
2018
5
Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study. ( 29322530 )
2018
6
Allergic contact dermatitis caused by topical ketoconazole: a relevant issue? Review of ketoconazole-positive patch tests. ( 29430708 )
2018
7
Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly. ( 29380012 )
2018
8
Involvement of the Negative Feedback of IL-33 Signaling in the Anti-Inflammatory Effect of Electro-acupuncture on Allergic Contact Dermatitis via Targeting MicroRNA-155 in Mast Cells. ( 29404871 )
2018
9
The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis. ( 29305764 )
2018
10
Allergic contact dermatitis caused by OlanedineAr (olanexidine gluconate), a new antiseptic. ( 29341182 )
2018
11
Allergic contact dermatitis caused by Solvent Orange 60 in spectacle frames in Japan. ( 29265444 )
2018
12
Allergic contact dermatitis caused by triethylenetetramine: the glue is the clue. ( 29392782 )
2018
13
A private case of allergic contact dermatitis. ( 29341989 )
2018
14
A novel case of a brush with discomfort: allergic contact dermatitis caused by mercaptobenzothiazole in rubber components of a toothbrush. ( 29446120 )
2018
15
Occupational allergic contact dermatitis caused by antibiotics in healthcare workersA -A relationship with non-immediate drug eruptions. ( 29399806 )
2018
16
Non-occupational allergic contact dermatitis caused by long-lasting nail polish kits for home use: 'the tip of the iceberg'. ( 29327355 )
2018
17
Possible role of regional variation in allergic contact dermatitis: case report. ( 29430710 )
2018
18
Systemic allergic contact dermatitis associated with topical diltiazem and/or cinchocaine. ( 29423962 )
2018
19
Allergic Contact Dermatitis. ( 27886903 )
2017
20
A Case of a Paediatric Patient With Allergic Contact Dermatitis to Benzoyl Peroxide. ( 28922933 )
2017
21
Allergic contact dermatitis caused by nail acrylates in Europe. An EECDRG study. ( 29266254 )
2017
22
Chronic Allergic Contact Dermatitis Due to Chlorhexidine. ( 28939138 )
2017
23
Allergic contact dermatitis caused by clindamycin mimicking 'retinoid flare'. ( 28766800 )
2017
24
Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes: in search of the culprit allergen. ( 28776709 )
2017
25
Allergic contact dermatitis caused by exfoliating socks. ( 27957756 )
2017
26
Diagnosis and management of allergic contact dermatitis in children: common allergens that can be easily missed. ( 28525402 )
2017
27
Differential Diagnosis of Palmoplantar Eczema in Psoriatico: Chronic Allergic Contact Dermatitis and/or Psoriasis? ( 28853491 )
2017
28
Allergic contact dermatitis caused by isobornyl acrylate in FreestyleAr Libre, a newly introduced glucose sensor. ( 28804907 )
2017
29
Effects of Acupuncture on 1-chloro-2,4-dinitrochlorobenzene-induced Allergic Contact Dermatitis in Mice. ( 28889842 )
2017
30
Suppressive Effects of Mesenchymal Stem Cells in Adipose Tissue on Allergic Contact Dermatitis. ( 28761285 )
2017
31
Intralesional Treatment With 5-Fluorouracil and Steroid Improves Allergic Contact Dermatitis Without Causing Skin Atrophy and Rebound Lesions. ( 28338541 )
2017
32
Allergic contact dermatitis caused by benzoic acid and lauryl glucoside in a sunscreen. ( 28766797 )
2017
33
Characterizing the Diagnosis and Treatment of Allergic Contact Dermatitis to 2-Octyl Cyanoacrylate Used for Skin Closure in Elective Orthopedic Surgery. ( 28811110 )
2017
34
Care of pets entails the risk of allergic contact dermatitis caused by plants. ( 28872199 )
2017
35
Allergic Contact Dermatitis Due to Methylisothiazolinone in a Young Girl's Laundry Detergent. ( 28523864 )
2017
36
Allergic contact dermatitis caused by efinaconazole: positive patch test reactions up to 0.1% pet. ( 27957750 )
2017
37
Severe allergic contact dermatitis due to Polysporin. ( 28790058 )
2017
38
Probable allergic contact dermatitis from hydroquinone presenting as leukomelanoderma: Report of two cases. ( 28815722 )
2017
39
Allergic Contact Dermatitis to 3-o-Ethyl-L-Ascorbic Acid in Skin-lightening Cosmetics. ( 28002235 )
2017
40
Occupational allergic contact dermatitis caused by benzisothiazolinone in printing ink and soap. ( 27957753 )
2017
41
Occupational Allergic Contact Dermatitis due to Multiple Tropical Plant Species. ( 28529083 )
2017
42
Severe allergic contact dermatitis caused by octylisothiazolinone in a leather sofa: two new cases. ( 28766805 )
2017
43
Epidermolysis bullosa simplex complicated by allergic contact dermatitis caused by a hydrocolloid dressing. ( 28220564 )
2017
44
MicroRNA-21-Mediated Inhibition of Mast Cell Degranulation Involved in the Protective Effect of Berberine on 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis in Rats via p38 Pathway. ( 29282578 )
2017
45
Screening for skin-sensitizing allergens among patients with clinically suspected allergic contact dermatitis. ( 28889150 )
2017
46
Allergic contact dermatitis caused by resorcinol following a temporary black henna tattoo. ( 28766804 )
2017
47
Occupational allergic contact dermatitis caused by tetracaine in an otorhinolaryngologist. ( 27957755 )
2017
48
Improved transdermal delivery of morin efficiently inhibits allergic contact dermatitis. ( 28739503 )
2017
49
Polymorphic light eruption and IL-1 family members: any difference with allergic contact dermatitis? ( 28812775 )
2017
50
Allergic contact dermatitis caused by I/-aminocaproic acid in a purified sodium hyaluronate ophthalmic solution. ( 28766795 )
2017

Variations for Allergic Contact Dermatitis

Expression for Allergic Contact Dermatitis

Search GEO for disease gene expression data for Allergic Contact Dermatitis.

Pathways for Allergic Contact Dermatitis

Pathways related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
2
Show member pathways
13.86 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
3
Show member pathways
13.71 CCL17 CXCL8 CXCR3 IFNG IL10 IL17A
4
Show member pathways
13.59 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A
5
Show member pathways
13.47 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
6
Show member pathways
13.41 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
7
Show member pathways
13.36 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
8
Show member pathways
12.92 CXCL8 ICAM1 IFNG IL10 IL17A IL1B
9
Show member pathways
12.88 CXCL8 ICAM1 IFNG IL1B IL33 IL4
10
Show member pathways
12.77 CXCL8 IFNG IL1B IL33 TNF
11
Show member pathways
12.69 IFNG IL10 IL17A IL1B IL4 IL5
12
Show member pathways
12.65 IFNG IL10 IL17A IL1B TNF
13 12.65 IFNG IL10 IL17A IL1B IL4 TNF
14
Show member pathways
12.59 CXCL8 IFNG IL10 IL1B TNF
15
Show member pathways
12.53 IFNG IL10 IL17A IL1B IL4 IL5
16
Show member pathways
12.52 ICAM1 IFNG IL4 TNF
17
Show member pathways
12.42 IFNG IL10 IL4 IL5
18
Show member pathways
12.42 ICAM1 IFNG IL1B IL4 TNF
19
Show member pathways
12.39 CCL17 CXCL8 IFNG IL17A IL1B IL4
20
Show member pathways
12.35 IFNG IL10 IL1B IL4 TNF
21
Show member pathways
12.32 CXCL8 IFNG IL1B TNF
22 12.29 IFNG IL10 IL1B TNF
23
Show member pathways
12.28 CXCL8 IFNG IL1B IL4 TNF
24
Show member pathways
12.27 IFNG IL1B IL33 TNF
25 12.23 CXCL8 IL10 IL1B TNF
26 12.19 ICAM1 IFNG IL1B SELE TNF
27
Show member pathways
12.13 CXCL8 IFNG IL10 IL17A IL1B IL4
28 12.12 CXCL8 ICAM1 IFNG IL1B IL4 TNF
29 12.1 IFNG IL10 IL4 IL5 TNF
30 12.1 CXCL8 ICAM1 IL10 IL17A IL1B IL4
31
Show member pathways
12.05 IFNG IL10 IL17A IL1B TNF
32 12.04 ICAM1 IL1B SELE TNF
33 12.02 CXCL8 ICAM1 IL1B SELE TNF
34 12 CXCL8 IFNG IL10 IL1B TNF
35 11.99 IL1B IL4 IL5 TNF
36
Show member pathways
11.98 IFNG IL1B IL4
37 11.98 CXCL8 ICAM1 IFNG IL17A IL1B TNF
38 11.97 CXCL8 ICAM1 IL1B TNF
39 11.95 CXCL8 IFNG IL1B
40
Show member pathways
11.95 IFNG IL17A IL1B IL4
41 11.93 CXCL8 ICAM1 IFNG IL4 IL5 SELE
42
Show member pathways
11.89 CXCL8 ICAM1 IL17A
43
Show member pathways
11.89 CXCL8 IFNG IL4 IL5 TNF
44 11.87 CXCL8 IL10 IL1B TNF
45 11.85 CXCL8 IFNG IL1B
46 11.85 IFNG IL10 IL1B TNF
47 11.81 ICAM1 IL10 IL4 IL5 TNF
48
Show member pathways
11.79 CXCL8 ICAM1 IFNG IL1B SELE TNF
49 11.78 CCL17 IL10 IL4 IL5
50 11.78 CXCL8 IL1B IL4 IL5 TNF

GO Terms for Allergic Contact Dermatitis

Cellular components related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL17 CXCL8 IFNG IL10 IL17A IL1B
2 external side of plasma membrane GO:0009897 9.46 CXCR3 ICAM1 IL17A TNF
3 extracellular space GO:0005615 9.44 CCL17 CXCL8 ICAM1 IFNG IL10 IL17A

Biological processes related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.99 CCL17 IL10 IL17A IL1B
2 leukocyte migration GO:0050900 9.94 ICAM1 IL1B SELE TNF
3 response to lipopolysaccharide GO:0032496 9.91 ICAM1 IL10 IL1B SELE
4 chemotaxis GO:0006935 9.88 CCL17 CXCL8 CXCR3 IL4
5 movement of cell or subcellular component GO:0006928 9.85 CXCL8 CXCR3 IFNG
6 chemokine-mediated signaling pathway GO:0070098 9.84 CCL17 CXCL8 CXCR3
7 cellular response to lipopolysaccharide GO:0071222 9.84 CXCL8 ICAM1 IL10 TNF
8 regulation of insulin secretion GO:0050796 9.83 IFNG IL1B TNF
9 neutrophil chemotaxis GO:0030593 9.82 CCL17 CXCL8 IL1B
10 immune response GO:0006955 9.81 CCL17 CXCL8 IFNG IL10 IL17A IL1B
11 positive regulation of DNA binding transcription factor activity GO:0051091 9.8 IL10 IL1B IL5 TNF
12 calcium-mediated signaling GO:0019722 9.79 CXCL8 CXCR3 SELE
13 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL33 TNF
14 extrinsic apoptotic signaling pathway GO:0097191 9.73 IFNG IL33 TNF
15 cellular response to interleukin-1 GO:0071347 9.73 CCL17 CXCL8 ICAM1 IL17A
16 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
17 leukocyte tethering or rolling GO:0050901 9.7 SELE TNF
18 positive regulation of macrophage activation GO:0043032 9.7 IL10 IL33
19 negative regulation of endothelial cell apoptotic process GO:2000352 9.7 ICAM1 IL10 IL4
20 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
21 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
22 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 IL10
23 positive regulation of podosome assembly GO:0071803 9.68 IL5 TNF
24 positive regulation of immunoglobulin secretion GO:0051024 9.67 IL33 IL5
25 positive regulation of interleukin-13 production GO:0032736 9.67 IL33 IL4
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 ICAM1 IFNG IL1B TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
28 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
29 positive regulation of osteoclast differentiation GO:0045672 9.65 IFNG IL17A TNF
30 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL10 IL4
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 ICAM1 TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IFNG IL1B TNF
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
35 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
36 inflammatory response GO:0006954 9.61 CCL17 CXCL8 CXCR3 IL10 IL17A IL1B
37 positive regulation of fever generation GO:0031622 9.6 IL1B TNF
38 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
40 regulation of isotype switching GO:0045191 9.57 IL10 IL4
41 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
42 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 IFNG TNF
43 type 2 immune response GO:0042092 9.5 IL10 IL33 IL4
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG IL1B TNF
45 regulation of receptor activity GO:0010469 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B
46 positive regulation of transcription by RNA polymerase II GO:0045944 10.16 IL10 IL17A IL1B IL33 IL4 TNF
47 positive regulation of transcription, DNA-templated GO:0045893 10.08 IL10 IL1B IL4 IL5 TNF

Molecular functions related to Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 CCL17 CXCL8 IFNG IL10 IL17A IL1B

Sources for Allergic Contact Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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