MCID: ALL014
MIFTS: 32

Allergic Encephalomyelitis malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Allergic Encephalomyelitis

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Aliases & Descriptions for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 46
 
Experimental Autoimmune Encephalomyelitis 66

Classifications:



Summaries for Allergic Encephalomyelitis

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MalaCards based summary: Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to niemann-pick disease, type b and ovarian papillary cystadenoma. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways are Glial Cell Differentiation and Spinal Cord Injury. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are vision/eye and cellular.

Related Diseases for Allergic Encephalomyelitis

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Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to allergic encephalomyelitis

Symptoms for Allergic Encephalomyelitis

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Drugs & Therapeutics for Allergic Encephalomyelitis

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Drugs for Allergic Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
s 1 (combination)Phase 1343
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
2
BenzocainePhase 117941994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
3tannic acidNutraceuticalPhase 11794

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple SclerosisCompletedNCT01377870Phase 1, Phase 2
2Mesenchymal Stem Cells for the Treatment of MSActive, not recruitingNCT00781872Phase 1, Phase 2
3A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers.CompletedNCT01466322Phase 1
4A Pilot Study of Intermittent Calorie Restriction in Multiple SclerosisActive, not recruitingNCT02647502Phase 1

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

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Anatomical Context for Allergic Encephalomyelitis

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MalaCards organs/tissues related to Allergic Encephalomyelitis:

34
T cells, Brain, Spinal cord, B cells, Pituitary, Thyroid, Endothelial

Animal Models for Allergic Encephalomyelitis or affiliated genes

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MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5MBP, MOG, NOS2, PLP1
2MP:00053848.1FTH1, MBP, MOG, NOS2, PLP1
3MP:00036317.6FTH1, MBP, MOG, NOS2, PLP1
4MP:00053877.4FTH1, MBP, MOG, NOS2, PLP1, STAT4
5MP:00053977.2FTH1, MBP, MOG, NOS2, PLP1, STAT4

Publications for Allergic Encephalomyelitis

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Articles related to Allergic Encephalomyelitis:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
C16 peptide shown to prevent leukocyte infiltration and alleviate detrimental inflammation in acute allergic encephalomyelitis model. (23352465)
2013
2
Multiple linked quantitative trait loci within the Tmevd2/Eae3 interval control the severity of experimental allergic encephalomyelitis in DBA/2J mice. (20861860)
2010
3
Complement C5 regulates the expression of insulin-like growth factor binding proteins in chronic experimental allergic encephalomyelitis. (18692252)
2008
4
An Iranian herbal-marine medicine, MS14, ameliorates experimental allergic encephalomyelitis. (18570265)
2008
5
Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. (18802104)
2008
6
Gene-based delivery of IFN-beta is efficacious in a murine model of experimental allergic encephalomyelitis. (16800783)
2006
7
Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis. (16244108)
2006
8
Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis. (15145604)
2004
9
The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation. (15159442)
2004
10
Spinal motoneurone distress during experimental allergic encephalomyelitis. (15488028)
2004
11
Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course. (14530364)
2003
12
Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis. (11869804)
2002
13
Cuprizone and piperonyl butoxide, proposed inhibitors of T-cell function, attenuate experimental allergic encephalomyelitis in SJL mice. (11585623)
2001
14
Essential role of TGF-beta in the natural resistance to experimental allergic encephalomyelitis in rats. (11298338)
2001
15
Bone marrow-derived dendritic cells from experimental allergic encephalomyelitis induce immune tolerance to EAE in Lewis rats. (11529923)
2001
16
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. (11431007)
2001
17
Curative effects of recombinant human Interleukin-6 in DA rats with protracted relapsing experimental allergic encephalomyelitis. (11438171)
2001
18
Experimental allergic encephalomyelitis animal models for analyzing features of multiple sclerosis. (10729911)
2000
19
Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis. (10841980)
2000
20
Subtle effects on myelin basic protein-specific T cell responses can lead to a major reduction in disease susceptibility in experimental allergic encephalomyelitis. (10861037)
2000
21
Induction of resistance to active experimental allergic encephalomyelitis by myelin basic protein-specific Th2 cell lines generated in the presence of glucocorticoids and IL-4. (10741389)
2000
22
Neuroimmunology of multiple sclerosis and experimental allergic encephalomyelitis. (11359717)
2000
23
Gene therapy for chronic relapsing experimental allergic encephalomyelitis using cells expressing a novel soluble p75 dimeric TNF receptor. (10679120)
2000
24
Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85. (11133075)
2000
25
Galectin-3/MAC-2 in experimental allergic encephalomyelitis. (10619568)
1999
26
Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. (10072563)
1999
27
The role of the antigen-presenting cell in Fas-mediated direct and bystander killing: potential in vivo function of Fas in experimental allergic encephalomyelitis. (9916681)
1999
28
Early detection of liposome brain localization in rat experimental allergic encephalomyelitis. (10229016)
1999
29
Abnormalities of cardiac repolarization in multiple sclerosis: relationship with a model of allergic encephalomyelitis in rat. (9626255)
1998
30
The pattern of cytokine gene expression in lymphoid organs and peripheral blood mononuclear cells of mice with experimental allergic encephalomyelitis. (9670856)
1998
31
Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats. (9776710)
1998
32
Local gene therapy with CTLA4-immunoglobulin fusion protein in experimental allergic encephalomyelitis. (9862327)
1998
33
Prevention of experimental allergic encephalomyelitis by an antibody to CD45RB. (9878118)
1998
34
Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis. (9811889)
1998
35
Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. (9759903)
1998
36
Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. (9203563)
1997
37
Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. (9394784)
1997
38
Perfluoro-15-crown-5-ether labelled macrophages in adoptive transfer experimental allergic encephalomyelitis. (9167839)
1997
39
Suppression of acute experimental allergic encephalomyelitis in Lewis rats with a mycophenolic acid derivative. (9362104)
1997
40
Modulation of Outward K(+) Conductance Is a Post-Activational Event in Rat T Lymphocytes Responsible for the Adoptive Transfer of Experimental Allergic Encephalomyelitis. (11725140)
1997
41
Polygenic control of experimental allergic encephalomyelitis in Biozzi ABH and BALB/c mice. (9119975)
1997
42
A CD4-CDR3 peptide analog inhibits both primary and secondary autoreactive CD4+ T cell responses in experimental allergic encephalomyelitis. (8871674)
1996
43
PECAM-1 (CD31) expression in the central nervous system and its role in experimental allergic encephalomyelitis in the rat. (8892086)
1996
44
mRNA for NGF and p75 in the central nervous system of rats affected by experimental allergic encephalomyelitis. (8866783)
1996
45
Interferon-gamma confers resistance to experimental allergic encephalomyelitis. (8766573)
1996
46
Chronic Relapsing Experimental Allergic Encephalomyelitis in the SJL Mouse: Relevant Techniques (8954854)
1996
47
Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase. (8632054)
1996
48
Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis. (8189065)
1994
49
Interleukin-10 prevents experimental allergic encephalomyelitis in rats. (7515815)
1994
50
Uveitis and retinal vasculitis in acute experimental allergic encephalomyelitis in the Lewis rat: an ultrastructural study. (8462650)
1993

Variations for Allergic Encephalomyelitis

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Expression for genes affiliated with Allergic Encephalomyelitis

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Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for genes affiliated with Allergic Encephalomyelitis

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Pathways related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6MBP, PLP1
29.4MBP, NOS2
3
Show member pathways
9.0NOS2, STAT4

GO Terms for genes affiliated with Allergic Encephalomyelitis

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Cellular components related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:00432099.1MBP, MOG, PLP1

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axon ensheathmentGO:00083669.9MBP, PLP1
2substantia nigra developmentGO:00217629.9MBP, PLP1
3central nervous system developmentGO:00074179.5MBP, MOG
4myelinationGO:00425529.5MBP, PLP1

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:00199119.6MBP, PLP1

Sources for Allergic Encephalomyelitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet