MCID: ALL014
MIFTS: 32

Allergic Encephalomyelitis malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Allergic Encephalomyelitis

Aliases & Descriptions for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 50
Experimental Autoimmune Encephalomyelitis 69

Classifications:



Summaries for Allergic Encephalomyelitis

MalaCards based summary : Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to rickets due to defect in vitamin d 25-hydroxylation and spastic paraplegia 44, autosomal recessive. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Spinal Cord Injury and Glial Cell Differentiation. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related phenotypes are cellular and hematopoietic system

Related Diseases for Allergic Encephalomyelitis

Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 rickets due to defect in vitamin d 25-hydroxylation 10.1 MBP PLP1
2 spastic paraplegia 44, autosomal recessive 10.1 MBP PLP1
3 cervical adenoid basal carcinoma 10.1 MBP MOG
4 lipomatosis, multiple symmetric 10.1 MBP MOG
5 mohr-tranebjaerg syndrome 10.1 MBP PLP1
6 benjamin syndrome 10.1 CXCL10 MBP
7 clear cell adenoma 10.1 MBP MOG
8 korsakoff's amnesic syndrome 10.1 MBP PLP1
9 bladder signet ring cell adenocarcinoma 10.1 CXCL10 MBP
10 temtamy syndrome 10.1 CXCL10 MOG
11 schwannoma of twelfth cranial nerve 10.0 MBP MOG
12 niemann-pick disease 10.0 MBP MOG
13 proximal symphalangism 10.0 CXCL10 MBP
14 articulation disorder 10.0 MBP MOG
15 nerve fibre bundle defect 10.0 MBP MOG
16 persistent mullerian duct syndrome 10.0 MBP MOG PLP1
17 pulmonary hemosiderosis 10.0 MBP MOG PLP1
18 substance-induced psychosis 9.9 MBP MOG PLP1
19 epithelioid type angiomyolipoma 9.9 MBP MOG PLP1
20 thyroiditis 9.9
21 orchitis 9.9
22 status epilepticus 9.9 CXCL10 MBP MOG
23 neonatal jaundice 9.9 MBP MOG
24 endotheliitis 9.9
25 vaccinia 9.8
26 retinitis 9.8
27 neuronitis 9.8
28 pertussis 9.8
29 retinal vasculitis 9.8
30 vasculitis 9.8
31 optic neuritis 9.8
32 uveitis 9.8
33 neuritis 9.8
34 complex regional pain syndrome 9.8 CXCL10 MBP MOG PLP1
35 advanced sleep phase syndrome, familial, 1 9.8 CXCL10 MBP MOG PLP1
36 central nervous system disease 9.6
37 borna disease 9.6
38 obesity 9.6
39 glucocorticoid resistance 9.6
40 myasthenia gravis 9.6
41 herpes simplex 9.6
42 nervous system disease 9.6
43 meningitis 9.6
44 melanoma 9.6
45 b cell deficiency 9.6
46 demyelinating disease 9.6
47 alopecia-intellectual disability syndrome 9.2 CXCL10 FTH1 HLA-DRA MBP MOG PLP1

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to Allergic Encephalomyelitis

Symptoms & Phenotypes for Allergic Encephalomyelitis

MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.65 FTH1 MBP MOG PLP1 CXCL10
2 hematopoietic system MP:0005397 9.55 CXCL10 FTH1 MBP MOG PLP1
3 immune system MP:0005387 9.35 CXCL10 FTH1 MBP MOG PLP1
4 nervous system MP:0003631 9.02 CXCL10 FTH1 MBP MOG PLP1

Drugs & Therapeutics for Allergic Encephalomyelitis

Drugs for Allergic Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 1 1994-09-7, 94-09-7 2337
2 tannic acid Approved, Nutraceutical Phase 1
3
s 1 (combination) Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Mesenchymal Stem Cells for the Treatment of MS Unknown status NCT00781872 Phase 1, Phase 2
2 Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple Sclerosis Completed NCT01377870 Phase 1, Phase 2
3 A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers. Completed NCT01466322 Phase 1
4 A Pilot Study of Intermittent Calorie Restriction in Multiple Sclerosis Active, not recruiting NCT02647502 Phase 1

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

Anatomical Context for Allergic Encephalomyelitis

MalaCards organs/tissues related to Allergic Encephalomyelitis:

39
T Cells, Brain, Spinal Cord, B Cells, Thyroid, Pituitary, Endothelial

Publications for Allergic Encephalomyelitis

Articles related to Allergic Encephalomyelitis:

(show top 50) (show all 548)
id Title Authors Year
1
Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells. ( 27633171 )
2016
2
Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. ( 27846891 )
2016
3
G-CSF treatment promotes apoptosis of autoreactive T cells to restrict the inflammatory cascade and accelerate recovery in experimental allergic encephalomyelitis. ( 27771353 )
2016
4
Capparis ovata treatment suppresses inflammatory cytokine expression and ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice. ( 27609283 )
2016
5
GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat. ( 27212951 )
2016
6
Inflammation severely alters thyroid hormone signaling in the central nervous system during experimental allergic encephalomyelitis in rat: Direct impact on OPCs differentiation failure. ( 27404574 )
2016
7
Transplantation of Neural Stem Cells Cotreated with Thyroid Hormone and GDNF Gene Induces Neuroprotection in Rats of Chronic Experimental Allergic Encephalomyelitis. ( 26881104 )
2016
8
Effect of recombinant Lactococcus lactis producing myelin peptides on neuroimmunological changes in rats with experimental allergic encephalomyelitis. ( 27764517 )
2016
9
Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapy. ( 25569428 )
2015
10
Analysis of the direct injury effector of oligodendroglia cells or myelin sheath in an experimental allergic encephalomyelitis model induced by the MOG35-55 peptide. ( 26459920 )
2015
11
IL-15-secreting I^I'T cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. ( 25974878 )
2015
12
Effect of oral administration of pig spinal cord hydrolysate on clinical and histopathological symptoms of experimental allergic encephalomyelitis in rats. ( 26216115 )
2015
13
Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein. ( 26531618 )
2015
14
Role of TRIF Small Interference RNA (siRNA) in Chronic Experimental Allergic Encephalomyelitis (EAE). ( 26324415 )
2015
15
Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. ( 26557026 )
2015
16
Angiopoietin-1 and C16 Peptide Attenuate Vascular and Inflammatory Responses in Experimental Allergic Encephalomyelitis. ( 26553158 )
2015
17
Effect of oral genistein administration in early and late phases of allergic encephalomyelitis. ( 25429342 )
2014
18
In trans T cell tolerance exacerbates experimental allergic encephalomyelitis by interfering with protective antibody responses. ( 24196276 )
2014
19
Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis. ( 25205217 )
2014
20
Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infections. ( 24811478 )
2014
21
Cell-based delivery of brain-derived neurotrophic factor in experimental allergic encephalomyelitis. ( 24601738 )
2014
22
Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein. ( 24659161 )
2014
23
Vitamin D Therapy in Experimental Allergic Encephalomyelitis Could be Limited by Opposing Effects of Sphingosine 1-Phosphate and Gelsolin Dysregulation. ( 24722820 )
2014
24
Active inflammation increases the heterogeneity of MRI texture in mice with relapsing experimental allergic encephalomyelitis. ( 24246391 )
2014
25
Multiple Sclerosis and Experimental Allergic Encephalomyelitis. ( 24478934 )
2013
26
Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis. ( 24371118 )
2013
27
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. ( 24324591 )
2013
28
PFA-fixed Hsp60sp-loaded dendritic cells as a vaccine for the control of mouse experimental allergic encephalomyelitis. ( 24374852 )
2013
29
Ethyl-eicosapentaenoic acid ameliorates the clinical course of experimental allergic encephalomyelitis induced in dark agouti rats. ( 23642735 )
2013
30
C16 peptide shown to prevent leukocyte infiltration and alleviate detrimental inflammation in acute allergic encephalomyelitis model. ( 23352465 )
2013
31
Glatiramer acetate biases dendritic cells towards an anti-inflammatory phenotype by modulating OPN, IL-17, and RORI^t responses and by increasing IL-10 production in experimental allergic encephalomyelitis. ( 23141166 )
2013
32
Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB. ( 23602713 )
2013
33
All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocyte development. ( 23181351 )
2013
34
PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis. ( 25206651 )
2013
35
Targeting of autoantigens to DEC205a8_ dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice. ( 23945139 )
2013
36
Protection of Tregs, suppression of Th1 and Th17 cells, and amelioration of experimental allergic encephalomyelitis by a physically-modified saline. ( 23284794 )
2012
37
Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis. ( 22007951 )
2012
38
Therapeutic effet of phase ii enzyme inducers in experimental allergic encephalomyelitis (eae). ( 22846297 )
2012
39
H(1)R expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis. ( 23121973 )
2012
40
Effect of honey bee venom on lewis rats with experimental allergic encephalomyelitis, a model for multiple sclerosis. ( 24250492 )
2012
41
Calpain inhibition attenuated morphological and molecular changes in skeletal muscle of experimental allergic encephalomyelitis rats. ( 22715087 )
2012
42
Use of engineered bone marrow stem cells to deliver brain derived neurotrophic factor under the control of a tetracycline sensitive response element in experimental allergic encephalomyelitis. ( 22901507 )
2012
43
Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis. ( 22190363 )
2011
44
Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1. ( 21235533 )
2011
45
Super-high-dose methylprednisolone does not improve efficacy or induce glucocorticoid resistance in experimental allergic encephalomyelitis. ( 20616573 )
2011
46
Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate. ( 21111489 )
2011
47
T cell dynamics during induction of tolerance and suppression of experimental allergic encephalomyelitis. ( 21911603 )
2011
48
Early influx of macrophages determines susceptibility to experimental allergic encephalomyelitis in Dark Agouti (DA) rats. ( 21109309 )
2011
49
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis. ( 21131060 )
2011
50
Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis. ( 21536110 )
2011

Variations for Allergic Encephalomyelitis

Expression for Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for Allergic Encephalomyelitis

Pathways related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.03 CXCL10 MBP
2 9.53 MBP PLP1

GO Terms for Allergic Encephalomyelitis

Cellular components related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 MBP PLP1

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 MBP MOG
2 myelination GO:0042552 9.26 MBP PLP1
3 immune response GO:0006955 9.26 CXCL10 FTH1 HLA-DRA MBP
4 substantia nigra development GO:0021762 9.16 MBP PLP1
5 axon ensheathment GO:0008366 8.62 MBP PLP1

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of myelin sheath GO:0019911 8.62 MBP PLP1

Sources for Allergic Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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