MCID: ALL014
MIFTS: 46

Allergic Encephalomyelitis malady

Immune category

Summaries for Allergic Encephalomyelitis

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33MalaCards
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MalaCards: Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to arthritis and vasculitis. An important gene associated with Allergic Encephalomyelitis is MOG (myelin oligodendrocyte glycoprotein), and among its related pathways are Ceramide signalling and p75NTR negatively regulates cell cycle via SC1. The compounds cycloheximide and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and brain, and related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Allergic Encephalomyelitis

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

allergic encephalomyelitis 43
experimental autoimmune encephalomyelitis 61


Related Diseases for Allergic Encephalomyelitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to allergic encephalomyelitis

Clinical Features for Allergic Encephalomyelitis

Drugs & Therapeutics for Allergic Encephalomyelitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Allergic Encephalomyelitis

Drug clinical trials:

Search ClinicalTrials for Allergic Encephalomyelitis

Search NIH Clinical Center for Allergic Encephalomyelitis

Search CenterWatch for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

Anatomical Context for Allergic Encephalomyelitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Allergic Encephalomyelitis:

33
Skin, Spinal cord, Brain, Bone marrow, Thymus, Cortex, Retina, Skeletal muscle, Thyroid, Adrenal gland, Monocytes, T cells, B cells, Endothelial, Thalamus, Adrenal cortex, Pineal, Pituitary

Animal Models for Allergic Encephalomyelitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Allergic Encephalomyelitis

Sources:
51PubMed
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Articles related to Allergic Encephalomyelitis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
In trans T cell tolerance exacerbates experimental allergic encephalomyelitis by interfering with protective antibody responses. (24196276)
2014
2
Glatiramer acetate biases dendritic cells towards an anti-inflammatory phenotype by modulating OPN, IL-17, and RORI^t responses and by increasing IL-10 production in experimental allergic encephalomyelitis. (23141166)
2013
3
Ethyl-eicosapentaenoic acid ameliorates the clinical course of experimental allergic encephalomyelitis induced in dark agouti rats. (23642735)
2013
4
Therapeutic effet of phase ii enzyme inducers in experimental allergic encephalomyelitis (eae). (22846297)
2012
5
Changes in phospholipid composition of the spinal cord in rabbits with allergic encephalomyelitis as an experimental model of multiple sclerosis. (22808466)
2011
6
Complement C5 regulates the expression of insulin-like growth factor binding proteins in chronic experimental allergic encephalomyelitis. (18692252)
2008
7
von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis. (18688020)
2008
8
Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis. (18374360)
2008
9
Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis. (16244108)
2006
10
Permanent effector phenotype of neuroantigen-specific T cells acquired in the central nervous system during experimental allergic encephalomyelitis. (16198481)
2006
11
A novel MRI texture analysis of demyelination and inflammation in relapsing-remitting experimental allergic encephalomyelitis. (17354959)
2006
12
Treatment of mice with the suppressor of cytokine signaling-1 mimetic peptide, tyrosine kinase inhibitor peptide, prevents development of the acute form of experimental allergic encephalomyelitis and induces stable remission in the chronic relapsing/remitting form. (16210611)
2005
13
Converting relapsing remitting to secondary progressive experimental allergic encephalomyelitis (EAE) by ultraviolet B irradiation. (15710465)
2005
14
Pathology-guided MR analysis of acute and chronic experimental allergic encephalomyelitis spinal cord lesions at 1.5T. (16028251)
2005
15
Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. (16172262)
2005
16
Matrix metalloproteases activity and ultrastructural changes in the early phase of experimental allergic encephalomyelitis. The effect of oral treatment with spinal cord hydrolysate [correction of hydrolisate] proteins in Lewis rat. The pilot study. (15266785)
2004
17
Immunohistochemical localization of phosphorylated protein kinase R and phosphorylated eukaryotic initiation factor-2 alpha in the central nervous system of SJL mice with experimental allergic encephalomyelitis. (15160394)
2004
18
Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course. (14530364)
2003
19
Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis. (12667650)
2003
20
A role for caspase-1 and -3 in the pathology of experimental allergic encephalomyelitis : inflammation versus degeneration. (12414506)
2002
21
Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. (11867745)
2002
22
Beneficial effect of modified peptide inhibitor of alpha4 integrins on experimental allergic encephalomyelitis in Lewis rats. (11782963)
2002
23
Attenuation of experimental allergic encephalomyelitis in complement component 6-deficient rats is associated with reduced complement C9 deposition, P-selectin expression, and cellular infiltrate in spinal cords. (11970970)
2002
24
Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. (12395089)
2002
25
Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. (11960303)
2002
26
Antagonistic effects of human cyclic MBP(87-99) altered peptide ligands in experimental allergic encephalomyelitis and human T-cell proliferation. (11784132)
2002
27
Essential role of TGF-beta in the natural resistance to experimental allergic encephalomyelitis in rats. (11298338)
2001
28
Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. (10779748)
2000
29
Subtle effects on myelin basic protein-specific T cell responses can lead to a major reduction in disease susceptibility in experimental allergic encephalomyelitis. (10861037)
2000
30
Morphological changes in the skin during experimental allergic encephalomyelitis and multiple sclerosis: bases for new diagnostic test. (11177306)
2000
31
Priming with interleukin-1beta suppresses experimental allergic encephalomyelitis in the Lewis rat. (11106976)
2000
32
Further evidence for a role of nitric oxide in experimental allergic encephalomyelitis: aminoguanidine treatment modifies its clinical evolution. (10650128)
2000
33
NMR studies in demyelinating and non-demyelinating experimental allergic encephalomyelitis. An approach involving a dehydration procedure. (9885325)
1999
34
Microvascular and cellular responses in the retina of rats with acute experimental allergic encephalomyelitis (EAE). (9669699)
1998
35
Prevention of experimental allergic encephalomyelitis by an antibody to CD45RB. (9878118)
1998
36
Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis. (9846831)
1998
37
Early eosinophil infiltration into the optic nerve of mice with experimental allergic encephalomyelitis. (9800949)
1998
38
Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the gamma delta T cell receptor. (9046440)
1997
39
Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis. (8640862)
1996
40
PECAM-1 (CD31) expression in the central nervous system and its role in experimental allergic encephalomyelitis in the rat. (8892086)
1996
41
Opposing effects of CTLA4-Ig and anti-CD80 (B7-1) plus anti-CD86 (B7-2) on experimental allergic encephalomyelitis. (8642061)
1996
42
Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis. (8666945)
1996
43
Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors. (8608648)
1996
44
The relationship between human multiple sclerosis and rodent experimental allergic encephalomyelitis. (7544078)
1995
45
Experimental allergic encephalomyelitis in adult DA rats subjected to neonatal handling or gentling. (7540932)
1995
46
2-Buten-4-olide (2-B4O) inhibits experimental allergic encephalomyelitis (EAE) in Lewis rats. (8579727)
1995
47
Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. (7525700)
1994
48
Uveitis and retinal vasculitis in acute experimental allergic encephalomyelitis in the Lewis rat. (8150031)
1993
49
Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 2. (7689586)
1993
50
Genetic analysis of BALB/cJ subline resistance to actively induced experimental allergic orchitis (EAO) and experimental allergic encephalomyelitis (EAE). (2458211)
1988

Genetic Variations for Allergic Encephalomyelitis

Expression for genes affiliated with Allergic Encephalomyelitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for genes affiliated with Allergic Encephalomyelitis

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 56SinoBiological, 53R&D Systems, 30KEGG, 52QIAGEN
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Pathways related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3NGFR, NGF
210.3NGF, NGFR
3
Hide members
10.3NGFR, NGF
410.3NGF, NGFR
510.2PLP1, MBP
610.2NGF, NGFR, NTF3
710.2NGF, NTF3, NGFR
810.2NGF, NGFR, NTF3
9
Hide members
10.1HLA-DRA, IL12B, STAT4
1010.1NGFR, LTB4R, MBP
11
Hide members
10.1CD80, CD86, CTLA4
12
Immune response NFAT in immune response
Hide members
10.1CD80, CD86, HLA-DRA
13
Hide members
10.1CD86, HLA-DRA, CD80
14
Immune response ICOS pathway in T-helper cell
Hide members
10.1HLA-DRA, CD86, CD80
1510.1ADRBK1, GRK6, HLA-DRA
16
Hide members
10.0NGFR, LTA, NTF3, NGF
1710.0HLA-DRA, ITGAL, CD80
1810.0STAT4, CD86, IL12B, HLA-DRA
19
Hide members
10.0IL12B, CD80, CD86, STAT4
20
Hide members
10.0CD80, CD86, HLA-DRA, CTLA4
21
Hide members
10.0HLA-DRA, CD80, CD86, CTLA4
22
Hide members
9.9NGFR, CD80, LTA, IL12B, NTF3
23
Hide members
9.9IL12B, HLA-DRA, STAT4, CD86, CD80
24
Hide members
9.9CD86, ADRBK1, NGF, NGFR, CD80
25
Hide members
9.9CTLA4, CD80, CD86, STAT4, HLA-DRA
269.8CTLA4, CD80, CD86, ITGAL, HLA-DRA
27
Hide members
9.7STAT4, LTA, CD86, CD80, IL12B, HLA-DRA
28
Hide members
9.6HLA-DRA, STAT4, ITGAL, NTF3, NGFR, CD86
29
Hide members
9.6STAT4, IL12B, CD80, NGFR, LTA, NTF3
30
Hide members
9.6NGFR, NTF3, ITGAL, LTA, STAT4, IL12B
31
Hide members
9.6STAT4, ITGAL, NTF3, LTA, NGFR, CD80
32
Hide members
9.6CD86, ITGAL, LTA, IL12B, CD80, HLA-DRA
33
Hide members
9.4CD86, ADRBK1, CD80, OXER1, ITGAL, LTB4R

Compounds for genes affiliated with Allergic Encephalomyelitis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.8LTA
2endotoxin4510.5CD86
32,3-cyclic nucleotide4510.5PLP1, MBP, MOG
4belatacept45 1111.5CD86, CTLA4, CD80
5forskolin45 50 1112.5MBP, NGFR, NTF3
6abatacept45 1111.5CD80, CTLA4, CD86
7glatiramer acetate45 1111.5MOG, MBP, CTLA4, PLP1
8il-124510.5IL12B, STAT4, CD86
9k252a4510.4NTF3, NGF, NGFR
10glucose4510.4NGFR, MOG, NTF3
11glutamate4510.4MBP, ADRBK1, PLP1, NGFR
12sulfatide4510.4MBP, PLP1, ITGAL
13ctla4-ig4510.4CD86, CD80, MBP, CTLA4
14enterotoxin4510.4CTLA4, LTA, CD80
15rantes4510.3IL12B, ITGAL, LTA, NGFR
16cocaine45 1111.3PLP1, NTF3, MBP, NGF
17estradiol valerate4510.3NGFR, NGF
18gaba4510.3MBP, NGFR, PLP1, ADRBK1, NTF3
19serine4510.2OXER1, CTLA4, ADRBK1, MOG, LTA
20cyclic amp45 2411.2NTF3, PLP1, ADRBK1, ITGAL, PRMT1
21choline45 11 2412.2NGF, NTF3, MBP, NGFR
22prednisolone45 29 1112.2LTA, NGF, MBP, ITGAL
23allergens4510.2ITGAL, STAT4, CTLA4, CD86, CD80
2412-o-tetradecanoylphorbol 13-acetate4510.2NGF, NGFR, LTA, MBP, NTF3
25ly 25528360 4511.2OXER1, LTB4R
26ganglioside4510.2NTF3, NGF, NGFR, CTLA4, ITGAL, MBP
27phosphotyrosine4510.2NGFR, NGF, STAT4, MBP, ADRBK1
28thymidine45 2411.2MBP, CTLA4, NTF3, NGFR, NGF, PLP1
29histamine45 29 2412.1GRK6, ADRBK1, CD86, NGF, NGFR, NTF3
30leukotriene b445 60 2412.1GRK6, ADRBK1, LTB4R, ITGAL, OXER1
31cinalukast60 1111.1OXER1, LTB4R
32dexamethasone45 50 29 1113.1LTA, CD80, CD86, LTB4R, ITGAL, CTLA4
33fmlp4510.1ITGAL, LTB4R, ADRBK1
34phosphoinositide4510.1LTB4R, ADRBK1, MOG, ITGAL, NGF, NGFR
35mannose4510.1CD86, CD80, LTA, ITGAL
36ionomycin4510.0CD80, CTLA4, ITGAL, LTA
37cyclosporin a45 29 6012.0NGF, CD86, LTA, MBP, CTLA4, CD80
38cholesterol45 29 11 2413.0ITGAL, LTA, LTB4R, NGFR, PLP1, CTLA4
39wortmannin459.9NGF, CTLA4, NTF3, ITGAL, CD86, NGFR
40acetylcholine45 50 29 11 2413.9NTF3, MOG, MBP, ADRBK1, PLP1, NGF
4117-odya609.9LTB4R, OXER1
42phosphatidylinositol459.9ITGAL, CTLA4, STAT4, IL12B, NGFR, NTF3
43oxygen45 2410.9ITGAL, CD80, NGFR, FTH1, LTB4R, LTA
44retinoic acid45 2410.9NTF3, MBP, NGF, NGFR, LTB4R, LTA
45nitric oxide45 11 2411.8CD80, NGFR, LTA, NTF3, LTB4R, MOG
46cysteine459.8NGFR, NGF, PLP1, MBP, ITGAL, GRK6
47threonine459.8GRK6, ADRBK1, LTA, NGFR, NGF, ITGAL
48lipid459.3LTB4R, MBP, MOG, CTLA4, ITGAL, GRK6
49calcium45 50 11 2412.2LTB4R, NGFR, NGF, CD80, IL12B, LTA
50tyrosine459.1NTF3, OXER1, LTA, NGFR, NGF, CD80

GO Terms for genes affiliated with Allergic Encephalomyelitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9CD80, CD86, ITGAL, CTLA4
2plasma membraneGO:0058868.8ADRBK1, MOG, MBP, CTLA4, HLA-DRA, ITGAL

Biological processes related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1axon ensheathmentGO:00836610.4PLP1, MBP
2regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.3NGF, NGFR
3nerve developmentGO:02167510.3NGFR, NTF3
4T cell costimulationGO:03129510.2CTLA4, HLA-DRA, CD86, CD80
5central nervous system developmentGO:00741710.2MOG, MBP, NGFR
6positive regulation of apoptotic processGO:04306510.1CTLA4, LTA, NGFR, NGF
7cell-cell signalingGO:00726710.1CD80, CD86, LTA, NTF3
8positive regulation of interleukin-2 biosynthetic processGO:04508610.1CD86, CD80
9neurotrophin TRK receptor signaling pathwayGO:04801110.1NGFR, ADRBK1, CD80, CD86, NGF
10immune responseGO:00695510.0CD86, MBP, CTLA4, HLA-DRA, LTB4R, FTH1
11negative regulation of growth of symbiont in hostGO:0441309.9LTA, IL12B

Molecular functions related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor kinase activityGO:00470310.2ADRBK1, GRK6
2structural constituent of myelin sheathGO:01991110.1PLP1, MBP
3nerve growth factor bindingGO:04840610.0NGFR, NTF3

Products for genes affiliated with Allergic Encephalomyelitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Encephalomyelitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet