MCID: ALL014
MIFTS: 37

Allergic Encephalomyelitis

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Allergic Encephalomyelitis

MalaCards integrated aliases for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 49
Experimental Autoimmune Encephalomyelitis 69

Classifications:



External Ids:

UMLS 69 C0014072

Summaries for Allergic Encephalomyelitis

MalaCards based summary : Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to multiple sclerosis and optic neuritis. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways/superpathways are Spinal Cord Injury and Glial Cell Differentiation. The drugs s 1 (combination) and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related phenotypes are cellular and hematopoietic system

Wikipedia : 72 Experimental autoimmune encephalomyelitis, sometimes experimental allergic encephalomyelitis (EAE) is an... more...

Related Diseases for Allergic Encephalomyelitis

Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 29.6 CXCL10 MBP MOG PLP1
2 optic neuritis 29.5 MBP MOG PLP1
3 central nervous system disease 29.3 MBP MOG PLP1
4 neuritis 29.1 CXCL10 MBP MOG
5 nervous system disease 29.1 MBP MOG
6 demyelinating disease 28.4 CXCL10 MBP MOG PLP1
7 niemann-pick disease, type a 10.2 MBP PLP1
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
9 balo concentric sclerosis 10.1 MBP MOG
10 hereditary neuropathies 10.1 MBP PLP1
11 acute disseminated encephalomyelitis 10.1 MBP MOG
12 leukodystrophy, hypomyelinating, 2 10.1 MBP PLP1
13 panencephalitis, subacute sclerosing 10.1 MBP MOG
14 internuclear ophthalmoplegia 10.1 MBP MOG
15 myelitis 10.1 MBP MOG
16 spinal cord disease 10.1 MBP MOG
17 pelizaeus-merzbacher disease 10.1 MBP PLP1
18 blood group, i system 10.0
19 neuromyelitis optica 10.0 MBP MOG
20 orchitis 10.0
21 thyroiditis 10.0
22 autoimmune disease 10.0
23 autoimmune disease 1 10.0
24 endotheliitis 10.0
25 substance abuse 9.9 MOG PLP1
26 relapsing-remitting multiple sclerosis 9.9 MBP MOG
27 aging 9.9
28 cerebellar degeneration-related autoantigen 3 9.9
29 multiple mitochondrial dysfunctions syndrome 5 9.9
30 pertussis 9.9
31 retinal vasculitis 9.9
32 uveitis 9.9
33 vaccinia 9.9
34 retinitis 9.9
35 neuronitis 9.9
36 vasculitis 9.9
37 ring chromosome y syndrome 9.9
38 viral encephalitis 9.8 CXCL10 MBP
39 primary progressive multiple sclerosis 9.8 MBP MOG PLP1
40 tertiary neurosyphilis 9.8 CXCL10 MBP
41 secondary progressive multiple sclerosis 9.8 CXCL10 MBP
42 myasthenia gravis 9.7
43 body mass index quantitative trait locus 11 9.7
44 body mass index quantitative trait locus 9 9.7
45 body mass index quantitative trait locus 8 9.7
46 body mass index quantitative trait locus 4 9.7
47 body mass index quantitative trait locus 10 9.7
48 body mass index quantitative trait locus 7 9.7
49 body mass index quantitative trait locus 12 9.7
50 body mass index quantitative trait locus 14 9.7

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to Allergic Encephalomyelitis

Symptoms & Phenotypes for Allergic Encephalomyelitis

MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.65 CXCL10 FTH1 MBP MOG PLP1
2 hematopoietic system MP:0005397 9.55 MBP MOG PLP1 CXCL10 FTH1
3 immune system MP:0005387 9.35 CXCL10 FTH1 MBP MOG PLP1
4 nervous system MP:0003631 9.02 CXCL10 FTH1 MBP MOG PLP1

Drugs & Therapeutics for Allergic Encephalomyelitis

Drugs for Allergic Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
s 1 (combination) Phase 1
2
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
3 tannic acid Approved, Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mesenchymal Stem Cells for the Treatment of MS Unknown status NCT00781872 Phase 1, Phase 2
2 Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple Sclerosis Completed NCT01377870 Phase 1, Phase 2
3 A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers. Completed NCT01466322 Phase 1 GSK2018682 CD2 Capsule; GSK2018682 CD3 non-micronised Tablet; GSK2018682 CD3 micronised Tablet; GSK2018682 CD3 non-micronised Tablet in fed state
4 A Pilot Study of Intermittent Calorie Restriction in Multiple Sclerosis Completed NCT02647502

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

Anatomical Context for Allergic Encephalomyelitis

MalaCards organs/tissues related to Allergic Encephalomyelitis:

38
T Cells, Brain, Spinal Cord, B Cells, Pituitary, Thyroid, Endothelial

Publications for Allergic Encephalomyelitis

Articles related to Allergic Encephalomyelitis:

(show top 50) (show all 557)
# Title Authors Year
1
Neuroprotective Effects of Melatonin on Experimental Allergic Encephalomyelitis Mice Via Anti-Oxidative Stress Activity. ( 29450696 )
2018
2
Metabolomics approaches in experimental allergic encephalomyelitis. ( 29224959 )
2018
3
Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy. ( 28271325 )
2017
4
Glyceryl Tribenzoate: A Flavoring Ingredient, Inhibits the Adoptive Transfer of Experimental Allergic Encephalomyelitis via TGF-I^: Implications for Multiple Sclerosis Therapy. ( 28367355 )
2017
5
Cyclophilin inhibitor NIM811 ameliorates experimental allergic encephalomyelitis. ( 28789840 )
2017
6
Effect of dimethyl fumarate on heme oxygenase-1 expression in experimental allergic encephalomyelitis in rats. ( 29363907 )
2017
7
IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. ( 28801358 )
2017
8
Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1I+-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis. ( 28363955 )
2017
9
Transplantation of Neural Stem Cells Cotreated with Thyroid Hormone and GDNF Gene Induces Neuroprotection in Rats of Chronic Experimental Allergic Encephalomyelitis. ( 26881104 )
2016
10
GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat. ( 27212951 )
2016
11
Effect of recombinant Lactococcus lactis producing myelin peptides on neuroimmunological changes in rats with experimental allergic encephalomyelitis. ( 27764517 )
2016
12
Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells. ( 27633171 )
2016
13
Inflammation severely alters thyroid hormone signaling in the central nervous system during experimental allergic encephalomyelitis in rat: Direct impact on OPCs differentiation failure. ( 27404574 )
2016
14
Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. ( 27846891 )
2016
15
Capparis ovata treatment suppresses inflammatory cytokine expression and ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice. ( 27609283 )
2016
16
G-CSF treatment promotes apoptosis of autoreactive T cells to restrict the inflammatory cascade and accelerate recovery in experimental allergic encephalomyelitis. ( 27771353 )
2016
17
Role of TRIF Small Interference RNA (siRNA) in Chronic Experimental Allergic Encephalomyelitis (EAE). ( 26324415 )
2015
18
IL-15-secreting I^I'T cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. ( 25974878 )
2015
19
Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapy. ( 25569428 )
2015
20
Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein. ( 26531618 )
2015
21
Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. ( 26557026 )
2015
22
Analysis of the direct injury effector of oligodendroglia cells or myelin sheath in an experimental allergic encephalomyelitis model induced by the MOG35-55 peptide. ( 26459920 )
2015
23
Effect of oral administration of pig spinal cord hydrolysate on clinical and histopathological symptoms of experimental allergic encephalomyelitis in rats. ( 26216115 )
2015
24
Angiopoietin-1 and C16 Peptide Attenuate Vascular and Inflammatory Responses in Experimental Allergic Encephalomyelitis. ( 26553158 )
2015
25
Cell-based delivery of brain-derived neurotrophic factor in experimental allergic encephalomyelitis. ( 24601738 )
2014
26
Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infections. ( 24811478 )
2014
27
Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein. ( 24659161 )
2014
28
Vitamin D Therapy in Experimental Allergic Encephalomyelitis Could be Limited by Opposing Effects of Sphingosine 1-Phosphate and Gelsolin Dysregulation. ( 24722820 )
2014
29
Effect of oral genistein administration in early and late phases of allergic encephalomyelitis. ( 25429342 )
2014
30
Active inflammation increases the heterogeneity of MRI texture in mice with relapsing experimental allergic encephalomyelitis. ( 24246391 )
2014
31
Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis. ( 25205217 )
2014
32
In trans T cell tolerance exacerbates experimental allergic encephalomyelitis by interfering with protective antibody responses. ( 24196276 )
2014
33
Ethyl-eicosapentaenoic acid ameliorates the clinical course of experimental allergic encephalomyelitis induced in dark agouti rats. ( 23642735 )
2013
34
Multiple Sclerosis and Experimental Allergic Encephalomyelitis. ( 24478934 )
2013
35
Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB. ( 23602713 )
2013
36
Glatiramer acetate biases dendritic cells towards an anti-inflammatory phenotype by modulating OPN, IL-17, and RORI^t responses and by increasing IL-10 production in experimental allergic encephalomyelitis. ( 23141166 )
2013
37
Targeting of autoantigens to DEC205a8_ dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice. ( 23945139 )
2013
38
All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocyte development. ( 23181351 )
2013
39
PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis. ( 25206651 )
2013
40
PFA-fixed Hsp60sp-loaded dendritic cells as a vaccine for the control of mouse experimental allergic encephalomyelitis. ( 24374852 )
2013
41
Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis. ( 24371118 )
2013
42
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. ( 24324591 )
2013
43
C16 peptide shown to prevent leukocyte infiltration and alleviate detrimental inflammation in acute allergic encephalomyelitis model. ( 23352465 )
2013
44
Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis. ( 22007951 )
2012
45
H(1)R expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis. ( 23121973 )
2012
46
Calpain inhibition attenuated morphological and molecular changes in skeletal muscle of experimental allergic encephalomyelitis rats. ( 22715087 )
2012
47
Protection of Tregs, suppression of Th1 and Th17 cells, and amelioration of experimental allergic encephalomyelitis by a physically-modified saline. ( 23284794 )
2012
48
Therapeutic effet of phase ii enzyme inducers in experimental allergic encephalomyelitis (eae). ( 22846297 )
2012
49
Use of engineered bone marrow stem cells to deliver brain derived neurotrophic factor under the control of a tetracycline sensitive response element in experimental allergic encephalomyelitis. ( 22901507 )
2012
50
Effect of honey bee venom on lewis rats with experimental allergic encephalomyelitis, a model for multiple sclerosis. ( 24250492 )
2012

Variations for Allergic Encephalomyelitis

Expression for Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for Allergic Encephalomyelitis

Pathways related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 CXCL10 MBP
2 9.53 MBP PLP1

GO Terms for Allergic Encephalomyelitis

Cellular components related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 MBP PLP1

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 MBP MOG
2 myelination GO:0042552 9.26 MBP PLP1
3 immune response GO:0006955 9.26 CXCL10 FTH1 HLA-DRA MBP
4 substantia nigra development GO:0021762 9.16 MBP PLP1
5 axon ensheathment GO:0008366 8.62 MBP PLP1

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of myelin sheath GO:0019911 8.62 MBP PLP1

Sources for Allergic Encephalomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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