MCID: ALL014
MIFTS: 32

Allergic Encephalomyelitis malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Allergic Encephalomyelitis

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Aliases & Descriptions for Allergic Encephalomyelitis:

Name: Allergic Encephalomyelitis 48
 
Experimental Autoimmune Encephalomyelitis 68

Classifications:



Summaries for Allergic Encephalomyelitis

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MalaCards based summary: Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to rickets due to defect in vitamin d 25-hydroxylation and spastic paraplegia 44, autosomal recessive. An important gene associated with Allergic Encephalomyelitis is MBP (Myelin Basic Protein), and among its related pathways are Glial Cell Differentiation and Spinal Cord Injury. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are cellular and hematopoietic system.

Related Diseases for Allergic Encephalomyelitis

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Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1rickets due to defect in vitamin d 25-hydroxylation10.1MBP, PLP1
2spastic paraplegia 44, autosomal recessive10.1MBP, PLP1
3cervical adenoid basal carcinoma10.1MBP, MOG
4lipomatosis, multiple symmetric10.1MBP, MOG
5mohr-tranebjaerg syndrome10.1MBP, PLP1
6benjamin syndrome10.1CXCL10, MBP
7clear cell adenoma10.1MBP, MOG
8korsakoff's amnesic syndrome10.1MBP, PLP1
9bladder signet ring cell adenocarcinoma10.1CXCL10, MBP
10temtamy syndrome10.1CXCL10, MOG
11schwannoma of twelfth cranial nerve10.0MBP, MOG
12niemann-pick disease10.0MBP, MOG
13proximal symphalangism10.0CXCL10, MBP
14articulation disorder10.0MBP, MOG
15nerve fibre bundle defect10.0MBP, MOG
16persistent mullerian duct syndrome10.0MBP, MOG, PLP1
17pulmonary hemosiderosis10.0MBP, MOG, PLP1
18substance-induced psychosis9.9MBP, MOG, PLP1
19epithelioid type angiomyolipoma9.9MBP, MOG, PLP1
20orchitis9.9
21thyroiditis9.9
22status epilepticus9.9CXCL10, MBP, MOG
23neonatal jaundice9.9MBP, MOG
24endotheliitis9.9
25pertussis9.8
26retinal vasculitis9.8
27optic neuritis9.8
28uveitis9.8
29neuritis9.8
30vaccinia9.8
31retinitis9.8
32neuronitis9.8
33vasculitis9.8
34complex regional pain syndrome9.8CXCL10, MBP, MOG, PLP1
35advanced sleep phase syndrome, familial, 19.8CXCL10, MBP, MOG, PLP1
36obesity9.6
37glucocorticoid resistance9.6
38myasthenia gravis9.6
39melanoma9.6
40b cell deficiency9.6
41demyelinating disease9.6
42central nervous system disease9.6
43borna disease9.6
44herpes simplex9.6
45nervous system disease9.6
46meningitis9.6
47alopecia-intellectual disability syndrome9.2CXCL10, FTH1, HLA-DRA, MBP, MOG, PLP1

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to allergic encephalomyelitis

Symptoms & Phenotypes for Allergic Encephalomyelitis

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MGI Mouse Phenotypes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.8CXCL10, FTH1, MBP, MOG, PLP1
2MP:00053978.7CXCL10, FTH1, MBP, MOG, PLP1
3MP:00053878.7CXCL10, FTH1, MBP, MOG, PLP1
4MP:00036317.9CXCL10, FTH1, MBP, MOG, PLP1

Drugs & Therapeutics for Allergic Encephalomyelitis

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Drugs for Allergic Encephalomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BenzocaineapprovedPhase 120161994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
2tannic acidapproved, NutraceuticalPhase 12016
3
s 1 (combination)Phase 1378
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1

Interventional clinical trials:

idNameStatusNCT IDPhase
1Mesenchymal Stem Cells for the Treatment of MSUnknown statusNCT00781872Phase 1, Phase 2
2Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple SclerosisCompletedNCT01377870Phase 1, Phase 2
3A Study to Assess the Relative Bioavailability of Different Formulations of GSK2018682, a Sphingosine-1-phosphate Receptor Subtype 1 Agonist, in Healthy Volunteers.CompletedNCT01466322Phase 1
4A Pilot Study of Intermittent Calorie Restriction in Multiple SclerosisActive, not recruitingNCT02647502Phase 1

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

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Anatomical Context for Allergic Encephalomyelitis

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MalaCards organs/tissues related to Allergic Encephalomyelitis:

36
T cells, Brain, Spinal cord, B cells, Pituitary, Thyroid, Endothelial

Publications for Allergic Encephalomyelitis

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Articles related to Allergic Encephalomyelitis:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Enterococcus faecium strain L-3 and glatiramer acetate ameliorate experimental allergic encephalomyelitis in rats by affecting different populations of immune cells. (27633171)
2016
2
Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis. (27846891)
2016
3
G-CSF treatment promotes apoptosis of autoreactive T cells to restrict the inflammatory cascade and accelerate recovery in experimental allergic encephalomyelitis. (27771353)
2016
4
Capparis ovata treatment suppresses inflammatory cytokine expression and ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice. (27609283)
2016
5
GDNF Enhances Therapeutic Efficiency of Neural Stem Cells-Based Therapy in Chronic Experimental Allergic Encephalomyelitis in Rat. (27212951)
2016
6
Inflammation severely alters thyroid hormone signaling in the central nervous system during experimental allergic encephalomyelitis in rat: Direct impact on OPCs differentiation failure. (27404574)
2016
7
Transplantation of Neural Stem Cells Cotreated with Thyroid Hormone and GDNF Gene Induces Neuroprotection in Rats of Chronic Experimental Allergic Encephalomyelitis. (26881104)
2016
8
Effect of recombinant Lactococcus lactis producing myelin peptides on neuroimmunological changes in rats with experimental allergic encephalomyelitis. (27764517)
2016
9
Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapy. (25569428)
2015
10
Analysis of the direct injury effector of oligodendroglia cells or myelin sheath in an experimental allergic encephalomyelitis model induced by the MOG35-55 peptide. (26459920)
2015
11
IL-15-secreting I^I'T cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. (25974878)
2015
12
Effect of oral administration of pig spinal cord hydrolysate on clinical and histopathological symptoms of experimental allergic encephalomyelitis in rats. (26216115)
2015
13
Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein. (26531618)
2015
14
Role of TRIF Small Interference RNA (siRNA) in Chronic Experimental Allergic Encephalomyelitis (EAE). (26324415)
2015
15
Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice. (26557026)
2015
16
Angiopoietin-1 and C16 Peptide Attenuate Vascular and Inflammatory Responses in Experimental Allergic Encephalomyelitis. (26553158)
2015
17
Effect of oral genistein administration in early and late phases of allergic encephalomyelitis. (25429342)
2014
18
In trans T cell tolerance exacerbates experimental allergic encephalomyelitis by interfering with protective antibody responses. (24196276)
2014
19
Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis. (25205217)
2014
20
Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infections. (24811478)
2014
21
Cell-based delivery of brain-derived neurotrophic factor in experimental allergic encephalomyelitis. (24601738)
2014
22
Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein. (24659161)
2014
23
Vitamin D Therapy in Experimental Allergic Encephalomyelitis Could be Limited by Opposing Effects of Sphingosine 1-Phosphate and Gelsolin Dysregulation. (24722820)
2014
24
Active inflammation increases the heterogeneity of MRI texture in mice with relapsing experimental allergic encephalomyelitis. (24246391)
2014
25
Multiple Sclerosis and Experimental Allergic Encephalomyelitis. (24478934)
2013
26
Histamine H2 receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis. (24371118)
2013
27
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. (24324591)
2013
28
PFA-fixed Hsp60sp-loaded dendritic cells as a vaccine for the control of mouse experimental allergic encephalomyelitis. (24374852)
2013
29
Ethyl-eicosapentaenoic acid ameliorates the clinical course of experimental allergic encephalomyelitis induced in dark agouti rats. (23642735)
2013
30
C16 peptide shown to prevent leukocyte infiltration and alleviate detrimental inflammation in acute allergic encephalomyelitis model. (23352465)
2013
31
Glatiramer acetate biases dendritic cells towards an anti-inflammatory phenotype by modulating OPN, IL-17, and RORI^t responses and by increasing IL-10 production in experimental allergic encephalomyelitis. (23141166)
2013
32
Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB. (23602713)
2013
33
All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocyte development. (23181351)
2013
34
PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis. (25206651)
2013
35
Targeting of autoantigens to DEC205a8_ dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice. (23945139)
2013
36
Protection of Tregs, suppression of Th1 and Th17 cells, and amelioration of experimental allergic encephalomyelitis by a physically-modified saline. (23284794)
2012
37
Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis. (22007951)
2012
38
Therapeutic effet of phase ii enzyme inducers in experimental allergic encephalomyelitis (eae). (22846297)
2012
39
H(1)R expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis. (23121973)
2012
40
Effect of honey bee venom on lewis rats with experimental allergic encephalomyelitis, a model for multiple sclerosis. (24250492)
2012
41
Calpain inhibition attenuated morphological and molecular changes in skeletal muscle of experimental allergic encephalomyelitis rats. (22715087)
2012
42
Use of engineered bone marrow stem cells to deliver brain derived neurotrophic factor under the control of a tetracycline sensitive response element in experimental allergic encephalomyelitis. (22901507)
2012
43
Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis. (22190363)
2011
44
Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1. (21235533)
2011
45
Super-high-dose methylprednisolone does not improve efficacy or induce glucocorticoid resistance in experimental allergic encephalomyelitis. (20616573)
2011
46
Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate. (21111489)
2011
47
T cell dynamics during induction of tolerance and suppression of experimental allergic encephalomyelitis. (21911603)
2011
48
Early influx of macrophages determines susceptibility to experimental allergic encephalomyelitis in Dark Agouti (DA) rats. (21109309)
2011
49
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis. (21131060)
2011
50
Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis. (21536110)
2011

Variations for Allergic Encephalomyelitis

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Expression for genes affiliated with Allergic Encephalomyelitis

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Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for genes affiliated with Allergic Encephalomyelitis

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Pathways related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6MBP, PLP1
29.5CXCL10, MBP

GO Terms for genes affiliated with Allergic Encephalomyelitis

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Cellular components related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:00432099.6MBP, PLP1

Biological processes related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axon ensheathmentGO:000836610.3MBP, PLP1
2central nervous system developmentGO:000741710.2MBP, MOG
3myelinationGO:004255210.1MBP, PLP1
4substantia nigra developmentGO:00217629.6MBP, PLP1
5immune responseGO:00069558.6CXCL10, FTH1, HLA-DRA, MBP

Molecular functions related to Allergic Encephalomyelitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:00199119.6MBP, PLP1

Sources for Allergic Encephalomyelitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet