MCID: ALL014
MIFTS: 41

Allergic Encephalomyelitis malady

Rare diseases, Immune diseases categories
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Summaries for Allergic Encephalomyelitis

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33MalaCards
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MalaCards: Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to encephalomyelitis and multiple sclerosis. An important gene associated with Allergic Encephalomyelitis is MOG (myelin oligodendrocyte glycoprotein), and among its related pathways are Cytokines and Inflammatory Response and IL12-mediated signaling events. The compounds 2,3-cyclic nucleotide and belatacept have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Aliases & Classifications for Allergic Encephalomyelitis

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Aliases & Descriptions:

allergic encephalomyelitis 43
experimental autoimmune encephalomyelitis 62


Related Diseases for Allergic Encephalomyelitis

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17GeneCards, 18GeneDecks
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Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1encephalomyelitis32.1CTLA4, CD86, PLP1, MOG
2multiple sclerosis31.2MOG, IL12B, PLP1, CD86, CTLA4
3optic neuritis30.5MOG, PLP1
4central nervous system disease30.2PLP1, MOG
5myasthenia gravis30.1CTLA4, CD86, PLP1, MOG
6orchitis10.4
7endotheliitis10.3
8neuronitis10.2
9retinal vasculitis10.2
10vaccinia10.2
11neuritis10.2
12pertussis10.2
13retinitis10.2
14thyroiditis10.2
15uveitis10.2
16vasculitis10.2
17borna disease10.1
18b cell deficiency10.1
19brain disease10.1
20herpes simplex10.1
21meningitis10.1
22nervous system disease10.1
23obesity10.1
24glucocorticoid resistance10.1
25primary progressive multiple sclerosis10.1PLP1, MOG
26guillain-barre syndrome10.1MOG, PLP1
27adrenoleukodystrophy10.0PLP1, MOG
28hepatitis b10.0IL12B, CTLA4
29nodular goiter10.0CTLA4, CD86
30autoimmune thyroiditis10.0IL12B, CTLA4
31wegener's granulomatosis10.0CD86, CTLA4
32encephalitis10.0IL12B, MOG
33atopy10.0CTLA4, IL12B
34polymyositis10.0CTLA4, CD86
35connective tissue disease10.0CTLA4, CD86
36hepatitis c10.0IL12B, CTLA4
37hypersensitivity reaction type ii disease10.0MOG, CD86, CTLA4
38systemic scleroderma10.0CTLA4, CD86
39tetanus10.0CD86, PLP1, MOG
40arthritis10.0CTLA4, CD86, FTH1
41graves' disease10.0IL12B, CD86, CTLA4
42atopic dermatitis10.0CTLA4, CD86, IL12B
43sarcoidosis10.0IL12B, CD86
44ulcerative colitis10.0CTLA4, CD86, IL12B
45inflammatory bowel disease10.0CTLA4, CD86, IL12B
46systemic lupus erythematosus10.0CTLA4, CD86, IL12B
47allergic asthma10.0CTLA4, CD86
48asthma10.0IL12B, CD86, CTLA4
49rheumatoid arthritis9.9CTLA4, CD86, IL12B, MOG
50burkitt's lymphoma9.9CTLA4, CD86, IL12B, HLA-DRA

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to allergic encephalomyelitis

Symptoms for Allergic Encephalomyelitis

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Drugs & Therapeutics for Allergic Encephalomyelitis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Allergic Encephalomyelitis

Search NIH Clinical Center for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

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Anatomical Context for Allergic Encephalomyelitis

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33MalaCards
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MalaCards organs/tissues related to Allergic Encephalomyelitis:

33
T cells, Brain, Spinal cord, B cells, Pituitary, Monocytes, Endothelial, Skeletal muscle, Thyroid, Testes, Bone, Cortex, Pineal, Retina, Skin, Thymus, Bone marrow, Thalamus

Animal Models for Allergic Encephalomyelitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9CTLA4, CD86, PLP1, IL12B, FTH1
2MP:00053977.5CTLA4, CD86, PLP1, IL12B, FTH1, MOG
3MP:00053877.3MOG, FTH1, IL12B, PLP1, CD86, CTLA4

Publications for Allergic Encephalomyelitis

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52PubMed
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Articles related to Allergic Encephalomyelitis:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1. (21235533)
2011
2
The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis. (21131060)
2011
3
Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate. (21111489)
2011
4
Experimental study of implantation of neurotropin-3 modified olfactory ensheathing cells in experimental allergic encephalomyelitis]. (20017332)
2009
5
Gene-based delivery of IFN-beta is efficacious in a murine model of experimental allergic encephalomyelitis. (16800783)
2006
6
How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. (16802293)
2006
7
Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis. (16244108)
2006
8
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis. (16120465)
2005
9
Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis. (15145604)
2004
10
Adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in experimental allergic encephalomyelitis. (14695330)
2004
11
Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course. (14530364)
2003
12
A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein. (12869140)
2003
13
Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis. (11869804)
2002
14
Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat. (11994126)
2002
15
Cuprizone and piperonyl butoxide, proposed inhibitors of T-cell function, attenuate experimental allergic encephalomyelitis in SJL mice. (11585623)
2001
16
Essential role of TGF-beta in the natural resistance to experimental allergic encephalomyelitis in rats. (11298338)
2001
17
Mycophenolate mofetil treatment accelerates recovery from experimental allergic encephalomyelitis. (11562063)
2001
18
Bone marrow-derived dendritic cells from experimental allergic encephalomyelitis induce immune tolerance to EAE in Lewis rats. (11529923)
2001
19
Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on T(h)1 cells that is augmented by IL-4. (11526091)
2001
20
Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. (10779748)
2000
21
Treatment of experimental allergic encephalomyelitis (EAE) induced by guinea pig myelin basic protein epitope 72-85 with a human MBP(87-99) analogue and effects of cyclic peptides. (11003134)
2000
22
Experimental allergic encephalomyelitis animal models for analyzing features of multiple sclerosis. (10729911)
2000
23
Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis. (10841980)
2000
24
Inhibition of experimental allergic encephalomyelitis with an antibody that recognizes a novel antigen expressed on lymphocytes, endothelial cells, and microglia. (10744067)
2000
25
A gene therapy or purified CTLA4IgG treatment of experimental allergic encephalomyelitis. (10642893)
1999
26
Galectin-3/MAC-2 in experimental allergic encephalomyelitis. (10619568)
1999
27
Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. (10072563)
1999
28
Correlation between MRI and clinico-pathological manifestations in Lewis rats protected from experimental allergic encephalomyelitis by acylated synthetic peptide of myelin basic protein. (10372527)
1999
29
Dendritic cells in experimental allergic encephalomyelitis and multiple sclerosis. (10695720)
1999
30
Type IV phosphodiesterase inhibition in experimental allergic encephalomyelitis of Lewis rats: sequential gene expression analysis of cytokines, adhesion molecules and the inducible nitric oxide synthase. (10385042)
1999
31
Microvascular and cellular responses in the retina of rats with acute experimental allergic encephalomyelitis (EAE). (9669699)
1998
32
B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. (9794370)
1998
33
Abnormalities of cardiac repolarization in multiple sclerosis: relationship with a model of allergic encephalomyelitis in rat. (9626255)
1998
34
The pattern of cytokine gene expression in lymphoid organs and peripheral blood mononuclear cells of mice with experimental allergic encephalomyelitis. (9670856)
1998
35
Analysis of TCR beta chains in Lewis rats with experimental allergic encephalomyelitis. II. Vbeta8.2+ T cells with limited CDR3 N region additions derive from the adult thymus. (9565361)
1998
36
Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. (9203563)
1997
37
Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. (9394784)
1997
38
Perfluoro-15-crown-5-ether labelled macrophages in adoptive transfer experimental allergic encephalomyelitis. (9167839)
1997
39
Suppression of acute experimental allergic encephalomyelitis in Lewis rats with a mycophenolic acid derivative. (9362104)
1997
40
Modulation of Outward K(+) Conductance Is a Post-Activational Event in Rat T Lymphocytes Responsible for the Adoptive Transfer of Experimental Allergic Encephalomyelitis. (11725140)
1997
41
Treatment of experimental allergic encephalomyelitis by selective removal of CD4+ T cells. (10225764)
1997
42
Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis. (8640862)
1996
43
Analysis of T cell receptor beta chains in the rat: I. Allelic polymorphism of V beta 8.2 is not a predisposing genetic factor in susceptibility to experimental allergic encephalomyelitis. (8892081)
1996
44
A CD4-CDR3 peptide analog inhibits both primary and secondary autoreactive CD4+ T cell responses in experimental allergic encephalomyelitis. (8871674)
1996
45
Experimental allergic encephalomyelitis in non-human primates: MRI and MRS may predict the type of brain damage. (7547186)
1995
46
Eicosenoids Modify Experimental Allergic Encephalomyelitis. (11854849)
1995
47
Staphylococcal enterotoxin B and tumor-necrosis factor-alpha-induced relapses of experimental allergic encephalomyelitis: protection by transforming growth factor-beta and interleukin-10. (7489740)
1995
48
The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity. (7544384)
1995
49
Experimental allergic encephalomyelitis, beta-adrenergic receptors and interferon gamma-secreting cells in beta-adrenergic agonist-treated rats. (8788119)
1995
50
Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis. (8189065)
1994

Variations for Allergic Encephalomyelitis

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Expression for genes affiliated with Allergic Encephalomyelitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for genes affiliated with Allergic Encephalomyelitis

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 53QIAGEN, 30KEGG, 54R&D Systems
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Pathways related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1IL12B, HLA-DRA
2
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1HLA-DRA, IL12B
3
Show member pathways
TCR signaling in naive CD8+ T cells38
9.0CD86, HLA-DRA
4
Show member pathways
8.6HLA-DRA, CD86, CTLA4
5
Show member pathways
8.6CTLA4, CD86, HLA-DRA
68.6CTLA4, CD86, HLA-DRA
7
Show member pathways
8.6CTLA4, CD86, HLA-DRA
88.6CTLA4, CD86, HLA-DRA
9
Show member pathways
8.6HLA-DRA, CD86, CTLA4
10
Show member pathways
8.5HLA-DRA, IL12B, CD86
11
Show member pathways
IL27-mediated signaling events38
8.5CD86, IL12B, HLA-DRA
12
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.5CD86, IL12B, HLA-DRA
13
Show member pathways
8.1CTLA4, CD86, IL12B, HLA-DRA

Compounds for genes affiliated with Allergic Encephalomyelitis

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45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
12,3-cyclic nucleotide459.8PLP1, MOG
2belatacept45 1110.7CTLA4, CD86
3abatacept45 1110.7CTLA4, CD86
4ctla4-ig459.6CTLA4, CD86
5il 10459.6CTLA4, IL12B
6il-12459.5IL12B, CD86
7silver459.5PLP1, MOG
8glatiramer acetate45 1110.4CTLA4, PLP1, MOG
9allergens459.4CD86, CTLA4
10acetylcholine45 51 29 24 1113.3CTLA4, PLP1, MOG
11sodium dodecylsulfate459.0CD86, IL12B
12wortmannin459.0IL12B, CD86, CTLA4
13nitric oxide45 24 1111.0CD86, IL12B, MOG
14lipid458.4MOG, FTH1, IL12B, PLP1, CTLA4

GO Terms for genes affiliated with Allergic Encephalomyelitis

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16Gene Ontology
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Cellular components related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.7CTLA4, CD86, PLP1, MOG, HLA-DRA

Biological processes related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to lipopolysaccharideGO:0712229.3CD86, IL12B
2positive regulation of activated T cell proliferationGO:0421049.0CD86, IL12B
3T cell costimulationGO:0312958.5HLA-DRA, CD86, CTLA4
4immune responseGO:0069558.2CTLA4, CD86, FTH1, HLA-DRA

Products for genes affiliated with Allergic Encephalomyelitis

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  • Antibodies
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Sources for Allergic Encephalomyelitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet