MCID: ALL014
MIFTS: 34

Allergic Encephalomyelitis malady

Immune diseases category

Summaries for Allergic Encephalomyelitis

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32MalaCards
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MalaCards: Allergic Encephalomyelitis, also known as experimental autoimmune encephalomyelitis, is related to encephalomyelitis and multiple sclerosis. An important gene associated with Allergic Encephalomyelitis is MOG (myelin oligodendrocyte glycoprotein), and among its related pathways are p75NTR negatively regulates cell cycle via SC1 and Ceramide signalling. The compounds cycloheximide and endotoxin have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Allergic Encephalomyelitis

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

allergic encephalomyelitis 42
experimental autoimmune encephalomyelitis 60


Related Diseases for Allergic Encephalomyelitis

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17GeneCards, 18GeneDecks
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Diseases related to Allergic Encephalomyelitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1encephalomyelitis32.1GRK6, NTF3, LTA, NGF, CD86, CD80
2multiple sclerosis31.2MOG, PLP1, IL12B, CD80, MBP, CTLA4
3arthritis30.6CTLA4, LTA, LTB4R, FTH1, CD86, CD80
4neuritis30.3MBP
5thyroiditis30.3CTLA4
6vasculitis30.3CD80, CTLA4
7optic neuritis30.3MOG, MBP, LTA, PLP1
8central nervous system disease30.3PLP1, NGF, MBP, MOG
9cholera30.2NGF, NTF3
10influenza30.2CD80, CD86, LTA, ITGAL
11glioblastoma multiforme30.2LTA, NGFR, NGF, CD86, PLP1
12leukemia30.2MBP, ITGAL, NTF3, LTA, NGFR, NGF
13rheumatoid arthritis30.2MOG, CTLA4, STAT4, ITGAL, NTF3, LTA
14herpes simplex30.1NTF3, NGFR, CD80, IL12B
15myasthenia gravis30.1MOG, MBP, CTLA4, LTA, CD86, CD80
16orchitis10.4
17choroiditis10.3
18cerebritis10.3
19spinal cord disease10.3
20vaccinia10.2
21neuronitis10.2
22retinal vasculitis10.2
23brain disease10.2
24nervous system disease10.2
25pertussis10.2
26retinitis10.2
27uveitis10.2
28iritis10.2
29scrapie10.2
30hypercalcemia10.2
31brain glioblastoma multiforme10.2
32hypothyroidism10.2
33pleurisy10.2
34pneumonia10.2
35neurologic diseases10.2
36borna disease10.1
37autoimmune disease of central nervous system10.1
38autoimmune disease of the nervous system10.1
39b cell deficiency10.1
40complement deficiency10.1
41meningitis10.1
42obesity10.1
43t cell deficiency10.1
44atopic dermatitis10.0NGF
45parkinson's disease10.0NGF
46polyneuropathy10.0MBP
47cocaine abuse10.0PLP1
48myopathy10.0NGF
49celiac disease10.0CTLA4
50galactosemia10.0FTH1

Graphical network of the top 20 diseases related to Allergic Encephalomyelitis:



Diseases related to allergic encephalomyelitis

Clinical Features for Allergic Encephalomyelitis

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Drugs & Therapeutics for Allergic Encephalomyelitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Allergic Encephalomyelitis

Drug clinical trials:

Search ClinicalTrials for Allergic Encephalomyelitis

Search NIH Clinical Center for Allergic Encephalomyelitis

Search CenterWatch for Allergic Encephalomyelitis

Genetic Tests for Allergic Encephalomyelitis

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Anatomical Context for Allergic Encephalomyelitis

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Animal Models for Allergic Encephalomyelitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Allergic Encephalomyelitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.0MOG, LTA, FTH1, NGFR, PLP1
2MP:00053919.9MOG, NTF3, NGFR, NGF, PLP1
3MP:00053699.7MOG, NTF3, NGFR, NGF, CD86, PLP1
4MP:00053859.5NTF3, LTA, LTB4R, FTH1, NGFR, NGF
5MP:00107689.2MBP, CTLA4, STAT4, PRMT1, NTF3, LTA
6MP:00053869.2MOG, MBP, GRK6, NTF3, LTA, NGFR
7MP:00053979.0LTA, ITGAL, STAT4, CTLA4, MBP, MOG
8MP:00053848.9LTA, ITGAL, STAT4, CTLA4, MBP, MOG
9MP:00053878.9ADRBK1, MOG, MBP, CTLA4, STAT4, ITGAL
10MP:00053768.8NTF3, PRMT1, ITGAL, STAT4, CTLA4, MBP

Publications for Allergic Encephalomyelitis

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Genetic Variations for Allergic Encephalomyelitis

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Expression for genes affiliated with Allergic Encephalomyelitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Encephalomyelitis

Search GEO for disease gene expression data for Allergic Encephalomyelitis.

Pathways for genes affiliated with Allergic Encephalomyelitis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 55SinoBiological, 52R&D Systems, 29KEGG, 51QIAGEN
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Pathways related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3NGFR, NGF
2
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10.3NGFR, NGF
3
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10.3NGF, NGFR
410.3NGFR, NGF
510.2PLP1, MBP
610.2NTF3, NGFR, NGF
710.2NGF, NGFR, NTF3
810.2NGF, NGFR, NTF3
9
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10.1HLA-DRA, STAT4, IL12B
1010.1NGFR, LTB4R, MBP
11
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10.1CD80, CD86, CTLA4
12
Immune response ICOS pathway in T-helper cell
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10.1CD80, CD86, HLA-DRA
13
Immune response NFAT in immune response
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10.1CD80, CD86, HLA-DRA
14
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10.1CD80, CD86, HLA-DRA
1510.1ADRBK1, GRK6, HLA-DRA
16
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10.0NTF3, LTA, NGFR, NGF
1710.0CD80, ITGAL, HLA-DRA
1810.0HLA-DRA, STAT4, CD86, IL12B
19
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10.0STAT4, CD86, CD80, IL12B
20
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10.0CTLA4, HLA-DRA, CD86, CD80
21
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10.0CD80, CD86, HLA-DRA, CTLA4
22
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9.9NTF3, LTA, NGFR, CD80, IL12B
23
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9.9HLA-DRA, STAT4, CD86, CD80, IL12B
24
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9.9NGFR, NGF, CD86, CD80, ADRBK1
25
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9.9CTLA4, HLA-DRA, STAT4, CD86, CD80
269.8CTLA4, HLA-DRA, ITGAL, CD86, CD80
27
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9.7IL12B, CD80, CD86, LTA, STAT4, HLA-DRA
28
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9.6HLA-DRA, STAT4, ITGAL, NTF3, NGFR, CD86
29
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9.6STAT4, ITGAL, NTF3, LTA, NGFR, CD80
30
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9.6STAT4, ITGAL, NTF3, LTA, NGFR, CD80
31
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9.6STAT4, ITGAL, NTF3, LTA, NGFR, CD80
32
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9.6CTLA4, HLA-DRA, ITGAL, LTA, CD86, CD80
33
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9.4ITGAL, OXER1, LTB4R, NGFR, NGF, CD86

Compounds for genes affiliated with Allergic Encephalomyelitis

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8LTA
2endotoxin4410.5CD86
32,3-cyclic nucleotide4410.5PLP1, MBP, MOG
4belatacept44 1111.5CD86, CTLA4, CD80
5forskolin44 49 1112.5MBP, NGFR, NTF3
6abatacept44 1111.5CD80, CTLA4, CD86
7glatiramer acetate44 1111.5MOG, MBP, CTLA4, PLP1
8il-124410.5IL12B, STAT4, CD86
9k252a4410.4NTF3, NGF, NGFR
10glucose4410.4NGFR, MOG, NTF3
11glutamate4410.4MBP, ADRBK1, PLP1, NGFR
12sulfatide4410.4MBP, PLP1, ITGAL
13ctla4-ig4410.4CD86, CD80, MBP, CTLA4
14enterotoxin4410.4CTLA4, LTA, CD80
15rantes4410.3IL12B, ITGAL, LTA, NGFR
16cocaine44 1111.3PLP1, NTF3, MBP, NGF
17estradiol valerate4410.3NGFR, NGF
18gaba4410.3MBP, NGFR, PLP1, ADRBK1, NTF3
19serine4410.2OXER1, CTLA4, ADRBK1, MOG, LTA
20cyclic amp44 2411.2NTF3, PLP1, ADRBK1, ITGAL, PRMT1
21choline44 11 2412.2NGF, NTF3, MBP, NGFR
22prednisolone44 28 1112.2LTA, NGF, MBP, ITGAL
23allergens4410.2ITGAL, STAT4, CTLA4, CD86, CD80
2412-o-tetradecanoylphorbol 13-acetate4410.2NGF, NGFR, LTA, MBP, NTF3
25ly 25528359 4411.2OXER1, LTB4R
26ganglioside4410.2NTF3, NGF, NGFR, CTLA4, ITGAL, MBP
27phosphotyrosine4410.2NGFR, NGF, STAT4, MBP, ADRBK1
28thymidine44 2411.2MBP, CTLA4, NTF3, NGFR, NGF, PLP1
29histamine44 28 2412.1GRK6, ADRBK1, CD86, NGF, NGFR, NTF3
30leukotriene b444 59 2412.1GRK6, ADRBK1, LTB4R, ITGAL, OXER1
31cinalukast59 1111.1OXER1, LTB4R
32dexamethasone44 49 28 1113.1LTA, CD80, CD86, LTB4R, ITGAL, CTLA4
33fmlp4410.1ITGAL, LTB4R, ADRBK1
34phosphoinositide4410.1LTB4R, ADRBK1, MOG, ITGAL, NGF, NGFR
35mannose4410.1CD86, CD80, LTA, ITGAL
36ionomycin4410.0CD80, CTLA4, ITGAL, LTA
37cyclosporin a44 28 5912.0NGF, CD86, LTA, MBP, CTLA4, CD80
38cholesterol44 28 11 2413.0ITGAL, LTA, LTB4R, NGFR, PLP1, CTLA4
39wortmannin449.9NGF, CTLA4, NTF3, ITGAL, CD86, NGFR
40acetylcholine44 49 28 11 2413.9NTF3, MOG, MBP, ADRBK1, PLP1, NGF
4117-odya599.9LTB4R, OXER1
42phosphatidylinositol449.9ITGAL, CTLA4, STAT4, IL12B, NGFR, NTF3
43oxygen44 2410.9ITGAL, CD80, NGFR, FTH1, LTB4R, LTA
44retinoic acid44 2410.9NTF3, MBP, NGF, NGFR, LTB4R, LTA
45nitric oxide44 11 2411.8CD80, NGFR, LTA, NTF3, LTB4R, MOG
46cysteine449.8NGFR, NGF, PLP1, MBP, ITGAL, GRK6
47threonine449.8GRK6, ADRBK1, LTA, NGFR, NGF, ITGAL
48lipid449.3LTB4R, MBP, MOG, CTLA4, ITGAL, GRK6
49calcium44 49 11 2412.2LTB4R, NGFR, NGF, CD80, IL12B, LTA
50tyrosine449.1NTF3, OXER1, LTA, NGFR, NGF, CD80

GO Terms for genes affiliated with Allergic Encephalomyelitis

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16Gene Ontology
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Cellular components related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9CD80, CD86, ITGAL, CTLA4
2plasma membraneGO:0058868.8ADRBK1, MOG, MBP, CTLA4, HLA-DRA, ITGAL

Biological processes related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1axon ensheathmentGO:00836610.4PLP1, MBP
2regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.3NGF, NGFR
3positive regulation of interleukin-2 biosynthetic processGO:04508610.2CD86, CD80
4T cell costimulationGO:03129510.2CTLA4, HLA-DRA, CD86, CD80
5nerve developmentGO:02167510.2NTF3, NGFR
6central nervous system developmentGO:00741710.2NGFR, MBP, MOG
7positive regulation of apoptotic processGO:04306510.1CTLA4, LTA, NGFR, NGF
8cell-cell signalingGO:00726710.1NTF3, LTA, CD86, CD80
9neurotrophin TRK receptor signaling pathwayGO:04801110.1NGFR, NGF, CD86, CD80, ADRBK1
10immune responseGO:00695510.0CD86, FTH1, LTB4R, HLA-DRA, CTLA4, MBP
11negative regulation of growth of symbiont in hostGO:0441309.9IL12B, LTA

Molecular functions related to Allergic Encephalomyelitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor kinase activityGO:00470310.2ADRBK1, GRK6
2structural constituent of myelin sheathGO:01991110.1PLP1, MBP
3nerve growth factor bindingGO:04840610.0NGFR, NTF3

Products for genes affiliated with Allergic Encephalomyelitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Encephalomyelitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet