Allergic Hypersensitivity Disease

Categories: Respiratory diseases, Immune diseases

Aliases & Classifications for Allergic Hypersensitivity Disease

Summaries for Allergic Hypersensitivity Disease

MedlinePlus : 41 an allergy is a reaction by your immune system to something that does not bother most other people. people who have allergies often are sensitive to more than one thing. substances that often cause reactions are pollen dust mites mold spores pet dander food insect stings medicines normally, your immune system fights germs. it is your body's defense system. in most allergic reactions, however, it is responding to a false alarm. genes and the environment probably both play a role. allergies can cause a variety of symptoms such as a runny nose, sneezing, itching, rashes, swelling, or asthma. allergies can range from minor to severe. anaphylaxis is a severe reaction that can be life-threatening. doctors use skin and blood tests to diagnose allergies. treatments include medicines, allergy shots, and avoiding the substances that cause the reactions. nih: national institute of allergy and infectious diseases

MalaCards based summary : Allergic Hypersensitivity Disease, also known as hypersensitivity, is related to neonatal jaundice and asthma, and has symptoms including coughing, exanthema and pruritus. An important gene associated with Allergic Hypersensitivity Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Alcaftadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and eye, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.

Related Diseases for Allergic Hypersensitivity Disease

Diseases related to Allergic Hypersensitivity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
id Related Disease Score Top Affiliating Genes
1 neonatal jaundice 30.3 IFNG IL10 IL4
2 asthma 28.3 CCL11 CCR3 CD79A EPX IFNG IL10
3 hypersensitivity vasculitis 12.3
4 hypersensitivity pneumonitis, familial 11.9
5 hypersensitivity syndrome, carbamazepine-induced 11.8
6 hypersensitivity reaction type iii disease 11.8
7 hypersensitivity reaction type iv disease 11.8
8 hypersensitivity reaction disease 11.8
9 hypersensitivity reaction type ii disease 11.8
10 myoclonic astatic epilepsy 11.0 IFNG IL4
11 cytoplasmic body myopathy 11.0 IL13 IL5
12 acute ackee fruit intoxication 11.0 IL10 IL4
13 marasmus 11.0 IL4 IL5 RNASE3
14 gastroschisis 11.0 IFNG IL5
15 abdominal tuberculosis 11.0 IL13 IL4 IL5
16 toxic diffuse goiter 11.0 IL13 IL5 RNASE3
17 glucose intolerance 10.9 IL13 IL4 IL5
18 myotubular myopathy with abnormal genital development 10.9 FCER2 IL4
19 anterior dislocation of lens 10.9 CCL11 IL4 RNASE3
20 spindle cell variant squamous cell breast carcinoma 10.9 IL13 IL4 IL5
21 eye accommodation disease 10.9 IFNG IL10 IL4
22 papillary follicular thyroid adenocarcinoma 10.9 IL5 RNASE3
23 cannabis abuse 10.9 CCL11 IL5 RNASE3
24 thelaziasis 10.9 IFNG IL10 IL4
25 vascular dementia 10.9 IL10 IL4 TLR9
26 cystadenocarcinoma 10.9 IL10 IL13
27 penis agenesis 10.9 CCL11 IL5
28 centronuclear myopathy 5 10.9 IFNG IL10 IL4
29 aortic arch interruption 10.9 IL13 IL5
30 heart septal defect 10.9 CD79A RNASE3
31 diabetic angiopathy 10.9 CD79A IL10 IL4
32 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.9 IFNG IL10 IL5
33 ostertagiasis 10.9 IL10 IL4 TLR9
34 frontal sinus schneiderian papilloma 10.9 IL13 IL5 TSLP
35 spindle cell hemangioma 10.9 IFNG IL10 IL4
36 glioblastoma multiforme 10.9 IL10 IL5 RNASE3
37 dieulafoy lesion 10.9 IFNG IL4 TLR9
38 papillary squamous carcinoma 10.9 IFNG IL10 IL13
39 early-onset zonular cataract 10.9 IFNG IL10 IL4
40 malignant renovascular hypertension 10.9 CD79A IFNG
41 gonococcal endophthalmia 10.9 IL5 SCP2 TLR9
42 acute monoblastic leukemia 10.9 IFNG IL10 IL4
43 dissociated nystagmus 10.9 EPX IL4 IL5
44 lymphocytic colitis 10.9 CD79A IFNG IL4
45 dumping syndrome 10.9 CD79A IFNG IL10
46 skin disease 10.9 IL4R IL5 RNASE3
47 orbital osteomyelitis 10.8 IFNG IL10 IL4
48 purpura fulminans 10.8 IL13 IL4 IL5 RNASE3
49 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.8 CD79A IFNG IL10
50 hypercalcinuria macular coloboma 10.8 IFNG IL4 IL4R

Graphical network of the top 20 diseases related to Allergic Hypersensitivity Disease:

Diseases related to Allergic Hypersensitivity Disease

Symptoms & Phenotypes for Allergic Hypersensitivity Disease

UMLS symptoms related to Allergic Hypersensitivity Disease:

coughing, exanthema, pruritus, snoring, stridor, injection site hypersensitivity, sore throat, vertigo/dizziness, equilibration disorder, abdominal pain, fever of unknown origin, (non-specific) malaise and fatigue, nausea and vomiting, syncope, signs and symptoms of ill-defined conditions

MGI Mouse Phenotypes related to Allergic Hypersensitivity Disease:

id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.27 CCL11 CCR3 CD79A ENPP3 EPX FCER2
2 immune system MP:0005387 10.19 SCP2 STAT6 TLR9 TSLP CCL11 CCR3
3 homeostasis/metabolism MP:0005376 10.13 IL4R IL5 SCP2 STAT6 TLR9 TSLP
4 digestive/alimentary MP:0005381 10.1 ENPP3 FCER2 IFNG IL10 IL13 IL4
5 integument MP:0010771 9.76 IFNG IL10 IL13 IL4 IL4R LALBA
6 liver/biliary system MP:0005370 9.56 IL10 IL4 IL4R IL5 SCP2 STAT6
7 respiratory system MP:0005388 9.36 IL5 STAT6 TSLP CCL11 CCR3 ENPP3

Drugs & Therapeutics for Allergic Hypersensitivity Disease

Drugs for Allergic Hypersensitivity Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 599)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Alcaftadine Approved Phase 4,Phase 3 147084-10-4 19371515
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
Dimenhydrinate Approved Phase 4 523-87-5 441281
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
Naphazoline Approved Phase 4,Phase 3 835-31-4 4436
Pheniramine Approved Phase 4,Phase 3 86-21-5 4761
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 242138-07-4
Capsaicin Approved Phase 4 404-86-4 1548943
Thrombin Approved Phase 4
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 83881-51-0 2678
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Phase 1 10102-43-9 145068
Amoxicillin Approved, Vet_approved Phase 4,Phase 2 26787-78-0 33613 2171
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
Metronidazole Approved Phase 4 443-48-1 4173
Povidone Approved Phase 4 9003-39-8
20 Povidone-iodine Approved Phase 4 25655-41-8
Teicoplanin Approved Phase 4 61036-62-2
Azelastine Approved Phase 4,Phase 3 58581-89-8 2267
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
Xylometazoline Approved Phase 4 526-36-3 5709
Budesonide Approved Phase 4,Phase 2 51333-22-3 63006 5281004
Ciclesonide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 126544-47-6, 141845-82-1 444033
Levocetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 130018-77-8
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
Desloratadine Approved, Investigational Phase 4,Phase 3 100643-71-8 124087
Loratadine Approved Phase 4,Phase 3,Phase 2,Phase 1 79794-75-5 3957
Epinastine Approved, Investigational Phase 4,Phase 3 80012-43-7 3241
Doxazosin Approved Phase 4 74191-85-8 3157
37 sodium fluoride Approved Phase 4 7681-49-4
Mannitol Approved, Investigational Phase 4,Phase 1 69-65-8 453 6251
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
Fexofenadine Approved Phase 4,Phase 2,Phase 1 83799-24-0 3348
Adenosine Approved, Investigational Phase 4 58-61-7 60961
Triamcinolone Approved, Vet_approved Phase 4,Phase 1 124-94-7 31307
Clevidipine Approved Phase 4 167221-71-8
Ketotifen Approved Phase 4,Phase 3,Phase 2,Phase 1 34580-14-8, 34580-13-7 3827
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1 104987-11-3 445643 439492
Loteprednol Approved Phase 4,Phase 3 82034-46-6, 129260-79-3 444025 9865442
Glycerol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 56-81-5 753
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
Diphenhydramine Approved Phase 4,Phase 3,Phase 1,Phase 2 58-73-1, 147-24-0 3100

Interventional clinical trials:

(show top 50) (show all 1135)

id Name Status NCT ID Phase Drugs
1 Ocular Allergy Treatment Practical Impact Trial Unknown status NCT01808768 Phase 4 Alcaftadine
2 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
3 TBE Vaccination in Allergic Patients Unknown status NCT02511535 Phase 4
4 Safety of Ertapenem in Beta-lactam Allergic Patients. Unknown status NCT01159379 Phase 4 ertapenem
5 Comparison of Tolerability Between Two Allergy Drops Unknown status NCT01390961 Phase 4 alacaftadine and naphazoline HCl & pheniramine maleate
6 Effect of Xolair on Airway Hyperresponsiveness Unknown status NCT00208234 Phase 4 Omalizumab;Placebo for Omalizumab;omalizumab
7 Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4 Sinol or Sinol-M nasal spray
8 Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites Unknown status NCT01052610 Phase 4 sublingual house dust mites allergen extract;placebo in sublingual applicator
9 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
10 Efficacy of Allergen Immunotherapy for Allergic Rhinitis in Thais Unknown status NCT01115595 Phase 4
11 Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis Unknown status NCT00488176 Phase 4 montelukast;cetirizine;montelukast and cetirizine;placebo
12 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
13 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
14 Exhaled NO Based Treatment of Chronic Obstructive Pulmonary Disease (COPD), ICS/LABA Versus LAMA Unknown status NCT02546349 Phase 4 fluticasone/salmeterol, tiotropium
15 4"S" - Seasonal Symptoms Suppression Study Unknown status NCT02557269 Phase 4 Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
16 Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses Unknown status NCT01337557 Phase 4 Bepotastine
17 Dietetic Versus Topical Steroids for Pediatric Eosinophilic Esophagitis Unknown status NCT01846962 Phase 4 Budesonide;Fluticasone
18 Comparison of Perennial and Preseasonal Subcutaneous Immunotherapy Completed NCT01555736 Phase 4 grass (80%) and rye (20%) pollens allergoids
19 A Trial of Immunological Outcomes of Sublingual Immunotherapy for House Dust Mite (D. Pteronyssinus) Allergy Completed NCT00250263 Phase 4 (agent for immunotherapy) Staloral;Placebo
20 Effectiveness and Safety of Desloratadine in Patients With Allergic Airway Disease During the Pollen Season (Study P03284) Completed NCT00779636 Phase 4 Desloratadine;Placebo
21 Non-invasive Ways to Evaluate Lung Disease After Treatment With Xolair Completed NCT00139152 Phase 4 Placebo;Xolair
22 Non-Pharmaceutical Treatment of Seasonal Allergic Conjunctivitis Completed NCT01569191 Phase 4 ELESTAT® (epinastine HCl ophthalmic solution) 0.05%
23 Prevention of Asthma and Allergy by Probiotic Lactobacillus GG Completed NCT00490425 Phase 4 Lactobacillus rhamnosus strain GG ATCC 53103 (LGG, 1010 cfu)
24 A Phase-IV, Open-label Study to Evaluate Safety/Tolerability of Once-daily AVAMYS (TM) Aqueous Nasal Spray 110mcg Among Vietnamese Adult Patients With Established Perennial Allergic Rhinitis Completed NCT01270958 Phase 4 Avamys aqueous nasal spray 110mcg
25 Does Fluticasone Propionate Reduce the Late Allergic Reaction When the Drug is Given Post-allergen? Completed NCT00716963 Phase 4 Fluticasone propionate (Flovent Diskus) 250 mcg;budesonide 400 mcg
26 Alpha-Blockers in Allergic Rhinitis (MAN 01) Completed NCT01946035 Phase 4 Doxazosin XL
27 Safety of Nasal Influenza Immunisation in Egg Allergic Children - The SNIFFLE 2 Study Completed NCT02111512 Phase 4 Administration of Live attenuated influenza vaccine (LAIV)
28 Fluticasone and Salmeterol in Allergic Rhinitis Completed NCT01388595 Phase 4 FLUTICASONE PROPRIONATE;Salmeterol;PLACEBO
29 A 6 Month Safety Study Of Ciclesonide Nasal Aerosol (Zetonna®) And Ciclesonide Nasal Spray (Omnaris®) In Subjects 12 Years And Older With Perennial Allergic Rhinitis (PAR) Completed NCT01654536 Phase 4 ciclesonide nasal aerosol;ciclesonide nasal spray
30 Allergic Inflammation in Rhinitis Patients Following Nasal Allergen Challenge Completed NCT01657097 Phase 4 INCS;Placebo
31 Grass Pollen Subcutaneous Immunotherapy in Elderly Patients Completed NCT02440243 Phase 4 Purethal;Purethal -placebo
32 Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations Completed NCT01430403 Phase 4 Inhaled Corticosteroid Boost Therapy (ICS)
33 A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease Completed NCT02065414 Phase 4
34 Levocetirizine 5 mg: Reduction of Symptoms, Airway Resistance and Sleep Impairment in Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
35 Study of the Effect of Fluticasone Furoate Nasal Spray on Spring Allergy Eye Symptoms Completed NCT00891436 Phase 4 Fluticasone furoate nasal spray;Placebo nasal spray
36 Study to Describe the Allergic Reactions to Factor IX in Patients With Hemophilia B Completed NCT00195221 Phase 4
37 iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions Completed NCT02552537 Phase 4 Omeprazole;Placebo
38 Therapeutic Utility of Xolair in Patients Undergoing Aspirin Desensitization Completed NCT00555971 Phase 4 Omalizumab;placebo
39 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
40 Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis Completed NCT01326247 Phase 4
41 Study of Two Marketed Ocular Anti-Allergy Medications in Subjects With Allergic Conjunctivitis Completed NCT00534794 Phase 4 Elestat;Pataday
42 Study Evaluating Allergic Reactions To Benefix In Hemophilia B Patients Completed NCT00244114 Phase 4 blood draw
43 The Duration of the Suppressive Effects of Desloratadine on Allergen Prick Tests After Discontinuation (P04441) Completed NCT00359138 Phase 4 desloratadine;levocetirizine;Desloratadine placebo tablet;Levocetirizine placebo capsule
44 Study to Evaluate the Effect of Omalizumab on Improving the Tolerability of Specific Immunotherapy in Patients With Persistent Allergic Asthma Completed NCT00267202 Phase 4 Placebo;Omalizumab;Immunotherapy;Immunotherapy
45 Patient Perception Study for AL-4943A Completed NCT01294969 Phase 4 AL-4943A
46 Study of Bronchodilation Effects of Cetirizine Completed NCT01781507 Phase 4 Cetirizine;Placebo
47 Compare the Efficacy of Levocetirizine and Montelukast to Placebo in Reducing SAR Symptoms in Ragweed Sensitive Subjects Completed NCT00295022 Phase 4 Levocetirizine
48 Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis Completed NCT00396162 Phase 4 probiotic containing L.rhamnosus R0011 strain
49 Safety of Oral Immunotherapy for Cow's Milk Allergy in School-aged Children Completed NCT01361347 Phase 4
50 The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726) Completed NCT00359216 Phase 4 Mometasone furoate nasal spray;Placebo

Search NIH Clinical Center for Allergic Hypersensitivity Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :

Cochrane evidence based reviews: hypersensitivity

Genetic Tests for Allergic Hypersensitivity Disease

Anatomical Context for Allergic Hypersensitivity Disease

MalaCards organs/tissues related to Allergic Hypersensitivity Disease:

Testes, Skin, Eye, Lung, T Cells, Breast, Bone

Publications for Allergic Hypersensitivity Disease

Variations for Allergic Hypersensitivity Disease

Expression for Allergic Hypersensitivity Disease

Search GEO for disease gene expression data for Allergic Hypersensitivity Disease.

Pathways for Allergic Hypersensitivity Disease

Pathways related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
13.68 CCL11 CCR3 FCER2 IFNG IL10 IL13
Show member pathways
13.53 CCL11 IFNG IL10 IL13 IL4 IL4R
Show member pathways
13.42 CCL11 CCR3 IL10 IL13 IL4 IL4R
Show member pathways
13.37 CCL11 FCER2 IFNG IL10 IL13 IL4
Show member pathways
13.28 CCL11 CCR3 IL10 IL13 IL4 IL4R
Show member pathways
Show member pathways
12.85 CCL11 EPX IFNG IL10 IL13 IL4
Show member pathways
12.65 CD79A IFNG IL10 IL4 IL4R MS4A2
Show member pathways
12.61 IFNG IL10 IL13 IL4 IL4R IL5
Show member pathways
12.59 CD79A IL13 IL4 IL5 MS4A2
12 12.54 CD79A IFNG IL10 IL4 STAT6 TLR9
Show member pathways
12.42 CCL11 FCER2 IL4 IL4R STAT6
Show member pathways
12.4 IFNG IL10 IL4 IL5
Show member pathways
12.36 CCL11 IFNG IL13 IL4 IL5
Show member pathways
12.18 CCL11 IFNG IL4 TLR9
Show member pathways
12.16 IFNG IL10 IL13 IL4 IL5
18 12.04 CCR3 CD79A IFNG IL10 IL4 IL5
Show member pathways
12 IFNG IL10 IL13 IL4 IL4R IL5
Show member pathways
11.94 IFNG IL4 IL4R TLR9
21 11.93 FCER2 IL4 IL4R IL5
22 11.9 IFNG IL10 IL4R STAT6
23 11.86 CCL11 FCER2 IL10 IL13 IL4 IL4R
24 11.83 IFNG IL13 IL4 IL5
25 11.78 IFNG IL10 IL13 IL4 IL5 TSLP
Show member pathways
11.74 IFNG IL4 IL5
27 11.74 IFNG IL10 TLR9
28 11.73 IL10 IL4 IL5 TLR9
29 11.71 CCL11 CCR3 IL13 IL4 IL5
30 11.57 FCER2 IL10 IL4R
31 11.55 FCER2 IL10 IL13 IL4
32 11.53 IFNG IL10 TLR9
33 11.37 IFNG IL10 TLR9
34 11.36 IFNG IL4 IL4R IL5
35 11.34 IFNG IL13 IL4 IL5 TSLP
36 11.3 CCL11 FCER2 IL10 IL4 IL4R IL5
37 11.24 IFNG IL10 IL13 IL4 IL5
38 11.23 CCL11 IL10 IL13 IL4 IL5
39 11.13 IFNG IL10 IL13 IL4 IL5
40 11.09 IL4 IL4R STAT6
41 10.95 IL13 IL4 IL4R IL5
42 10.9 CCL11 IFNG IL10 IL13 IL4 IL4R

GO Terms for Allergic Hypersensitivity Disease

Cellular components related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CCL11 EPX IFNG IL10 IL13 IL4
2 external side of plasma membrane GO:0009897 9.63 CD79A FCER2 IFNG IL13 IL4 MS4A2
3 extracellular region GO:0005576 9.5 CCL11 CSN1S1 ENPP3 EPX FCER2 IFNG

Biological processes related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.85 IFNG IL10 LALBA RNASE3 TLR9
2 inflammatory response GO:0006954 9.8 CCL11 CCR3 IL10 IL13 IL5 MS4A2
3 B cell differentiation GO:0030183 9.78 CD79A IL10 IL4
4 positive regulation of endothelial cell proliferation GO:0001938 9.77 CCL11 CCR3 IL10
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.67 IL10 IL13 IL4
6 microglial cell activation GO:0001774 9.64 IL13 IL4
7 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 FCER2 TLR9
8 response to molecule of bacterial origin GO:0002237 9.63 IL10 TLR9
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.62 IFNG IL4
10 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IFNG IL4
11 positive regulation of macrophage activation GO:0043032 9.61 IL10 IL13 IL4R
12 immune response GO:0006955 9.61 CCL11 ENPP3 IFNG IL10 IL13 IL4
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.59 IFNG IL4
14 type 2 immune response GO:0042092 9.58 IL10 IL4
15 negative regulation of interleukin-8 production GO:0032717 9.58 IL10 TLR9
16 positive regulation of mast cell degranulation GO:0043306 9.58 IL13 IL4 IL4R
17 positive regulation of killing of cells of other organism GO:0051712 9.57 FCER2 IFNG
18 interleukin-4-mediated signaling pathway GO:0035771 9.56 IL4R STAT6
19 regulation of isotype switching GO:0045191 9.55 IL10 IL4
20 regulation of proton transport GO:0010155 9.54 IL13 IL4
21 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IFNG IL10 IL4
22 positive regulation of isotype switching to IgE isotypes GO:0048295 9.52 IL4 STAT6
23 negative regulation of complement-dependent cytotoxicity GO:1903660 9.51 IL13 IL4
24 positive regulation of B cell proliferation GO:0030890 9.5 IL13 IL4 IL5
25 T-helper 1 cell lineage commitment GO:0002296 9.48 IL4 STAT6
26 defense response to protozoan GO:0042832 9.46 IFNG IL10 IL4 IL4R
27 defense response to Gram-negative bacterium GO:0050829 9.32 TLR9
28 positive regulation of immunoglobulin production GO:0002639 8.8 IL13 IL4 IL4R

Molecular functions related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL11 IFNG IL10 IL13 IL4 IL5
2 IgE binding GO:0019863 8.96 FCER2 MS4A2

Sources for Allergic Hypersensitivity Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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