MCID: ALL026
MIFTS: 59

Allergic Hypersensitivity Disease

Categories: Respiratory diseases, Immune diseases

Aliases & Classifications for Allergic Hypersensitivity Disease

Summaries for Allergic Hypersensitivity Disease

MedlinePlus : 40 An allergy is a reaction by your immune system to something that does not bother most other people. People who have allergies often are sensitive to more than one thing. Substances that often cause reactions are Pollen Dust mites Mold spores Pet dander Food Insect stings Medicines Normally, your immune system fights germs. It is your body's defense system. In most allergic reactions, however, it is responding to a false alarm. Genes and the environment probably both play a role. Allergies can cause a variety of symptoms such as a runny nose, sneezing, itching, rashes, swelling, or asthma. Allergies can range from minor to severe. Anaphylaxis is a severe reaction that can be life-threatening. Doctors use skin and blood tests to diagnose allergies. Treatments include medicines, allergy shots, and avoiding the substances that cause the reactions. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Allergic Hypersensitivity Disease, also known as hypersensitivity, is related to hypersensitivity reaction disease and egg allergy, and has symptoms including signs and symptoms of ill-defined conditions, syncope and nausea and vomiting. An important gene associated with Allergic Hypersensitivity Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include testes and skin, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods.

PubMed Health : 59
About allergies: Allergies arise if the body's immune system overreacts to foreign substances (allergens) that are usually harmless in most people, such as pollen or certain foods. The symptoms can vary a lot. In some cases they are quite mild, but they can also be a real nuisance and have a considerable impact in everyday life. Severe allergic reactions may be life-threatening.There are various treatment options for allergies. Some things that trigger allergies (allergens) are easy to avoid, whereas others aren't. Common allergens include the following:

Wikipedia : 72 Hypersensitivity (also called hypersensitivity reaction or intolerance) undesirable reactions produced... more...

Related Diseases for Allergic Hypersensitivity Disease

Diseases related to Allergic Hypersensitivity Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 hypersensitivity reaction disease 33.3 IFNG IL10 IL13 IL4 IL5 TLR9
2 egg allergy 30.3 IGHE IL4 IL5
3 strongyloidiasis 30.1 CCL11 IFNG IL13 IL5
4 intrinsic asthma 30.1 FCER2 IL4 IL5 RNASE3
5 esophagitis 30.0 CCL11 CCR3 IL13 IL5
6 peanut allergy 29.9 IFNG IGHE IL10 IL13
7 uveitis 29.9 IFNG IL10 IL4
8 common variable immunodeficiency 29.9 IFNG IL10 IL4 TLR9
9 otitis media 29.8 CCL11 IGHE IL10 IL4 RNASE3
10 urticaria 29.7 FCER2 HRH1 RNASE3 TPT1
11 esophagitis, eosinophilic, 1 29.7 CCL11 CCR3 EPX IL13 IL5 RNASE3
12 food allergy 29.6 CSN1S1 EPX IFNG IL10 IL13 IL4
13 dermatitis 29.6 CCL11 CCL17 IFNG IGES IGHE IL13
14 ige responsiveness, atopic 29.5 CSN1S1 FCER2 IFNG IGES IGHE IL10
15 allergic asthma 29.1 CCL11 CCL17 EPX IFNG IGHE IL10
16 asthma 28.0 CCL11 CCL17 CCR3 EPX FCER2 HRH1
17 dermatitis, atopic 28.0 CCL11 CCL17 CCR3 CSN1S1 EPX FCER2
18 hypersensitivity vasculitis 12.4
19 hypersensitivity pneumonitis, familial 12.3
20 extrinsic allergic alveolitis 12.0
21 hypersensitivity reaction type iii disease 11.9
22 hypersensitivity reaction type iv disease 11.9
23 asparagus, specific smell hypersensitivity 11.8
24 insect stings, hypersensitivity to 11.8
25 selective igm deficiency disease 10.7
26 mycoplasmal pneumonia 10.7 IFNG IL4
27 tropical endomyocardial fibrosis 10.7 IL10 IL4
28 eosinophilic fasciitis 10.7 IFNG IL5
29 cough variant asthma 10.7 IL4 IL5 RNASE3
30 persistent polyclonal b-cell lymphocytosis 10.7 FCER2 IL4
31 blepharoconjunctivitis 10.6 CCL11 IL4 RNASE3
32 loeffler endocarditis 10.6 IL5 RNASE3
33 penicillin allergy 10.6 IFNG IL13 IL4
34 intestinal schistosomiasis 10.6 IL13 IL4 IL5
35 hyperlucent lung 10.6 IFNG IL10 IL4
36 chronic tic disorder 10.6 IL13 IL4 IL5
37 pemphigoid gestationis 10.6 CCL11 IL5
38 cow milk allergy 10.6 IL10 IL5 RNASE3
39 chronic eosinophilic pneumonia 10.6 CCL11 IL5 RNASE3
40 beta-lactam allergy 10.6 IL10 IL13 IL4
41 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL13 IL5
42 baylisascariasis 10.6 IFNG IL10 IL4
43 cytokine deficiency 10.6 IL13 IL5 IL9
44 nut allergy 10.6 IL13 IL5 TLR9
45 buruli ulcer 10.6 IFNG IL10 IL4
46 scabies 10.6 CCL11 IL10 KITLG
47 multicentric castleman disease 10.6 IFNG IL10 IL5
48 poliomyelitis 10.6 IFNG IL10 IL4
49 ascaridiasis 10.6 IL10 IL13
50 primary systemic mycosis 10.6 IFNG IL10 IL4

Graphical network of the top 20 diseases related to Allergic Hypersensitivity Disease:



Diseases related to Allergic Hypersensitivity Disease

Symptoms & Phenotypes for Allergic Hypersensitivity Disease

UMLS symptoms related to Allergic Hypersensitivity Disease:


signs and symptoms of ill-defined conditions, syncope, nausea and vomiting, (non-specific) malaise and fatigue, fever of unknown origin, abdominal pain, equilibration disorder, vertigo/dizziness, sore throat, injection site hypersensitivity, tinnitus, stridor, snoring, pruritus, exanthema, coughing

MGI Mouse Phenotypes related to Allergic Hypersensitivity Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 EPX FCER2 IL5 HRH1 IL9 HRH4
2 digestive/alimentary MP:0005381 9.97 IL4 FCER2 IL5 IL9 IFNG KITLG
3 homeostasis/metabolism MP:0005376 9.93 IL4 FCER2 IL5 HRH1 HRH4 IL9
4 immune system MP:0005387 9.83 EPX FCER2 IL5 HRH1 IL9 HRH4
5 respiratory system MP:0005388 9.17 IL4 IL5 IFNG IL10 CCL11 IL13

Drugs & Therapeutics for Allergic Hypersensitivity Disease

PubMedHealth treatment related to Allergic Hypersensitivity Disease: 59

The best way to prevent allergic reactions is to avoid contact with the triggers (allergens). How well this works will mainly depend on the type of trigger. It’s often quite easy to avoid contact with things like certain foods or chemical substances. It’s almost impossible to avoid pollen, though. But pollen calendars and forecasts, for instance on the internet, can give you an idea of the pollen count in certain regions. People with dust mite allergies can somewhat lower their exposure to dust mites in their home by taking precautions such as using mite-proof bedding and removing "dust traps."The symptoms of many allergies can be treated with medication. Antihistamines and steroids are often used for this purpose. These medications are available in various forms, including tablets, nasal sprays and injections. They are mainly used in the treatment of allergic rhinitis (in the nose) and allergic conjunctivitis (in the eyes). Allergic reactions affecting the skin are also treated using steroid ointments or creams.A treatment known as allergen-specific immunotherapy (“desensitization”) can help reduce sensitivity to some allergens in the long term. Like with vaccines, this treatment approach involves exposing people to small amounts of the allergen. Here it is done at regular intervals by either injecting the allergen into your skin or placing it under your tongue. It takes about three to five years to complete allergen-specific immunotherapy. This approach is mainly used for the treatment of allergies to pollen (hay fever), dust mites and insect venom.There is currently no evidence that herbal or homeopathic products can help in the treatment of allergies. This is also true for acupuncture.

Search Clinical Trials , NIH Clinical Center for Allergic Hypersensitivity Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: hypersensitivity

Genetic Tests for Allergic Hypersensitivity Disease

Anatomical Context for Allergic Hypersensitivity Disease

MalaCards organs/tissues related to Allergic Hypersensitivity Disease:

38
Testes, Skin

Publications for Allergic Hypersensitivity Disease

Articles related to Allergic Hypersensitivity Disease:

(show top 50) (show all 1601)
# Title Authors Year
1
Bulla formation at the tuberculin skin test site in a patient with bullous pemphigoid: Koebnerization or severe delayed-type hypersensitivity? ( 29376506 )
2018
2
Drug-induced aseptic meningitis: A possible T-cell-mediated hypersensitivity. ( 29310902 )
2018
3
Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group. ( 29090524 )
2018
4
Hypersensitive Pneumonitis: an Initial Presentation of Chronic Granulomatous Disease in a Child. ( 29302845 )
2018
5
Myoclonus and hypersensitivity of the tail following intrathecal administration of morphine and bupivacaine in a cat. ( 29428303 )
2017
6
Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases. ( 28470390 )
2017
7
Review of "Patch Testing for Evaluation of Hypersensitivity to Implanted Metal Devices: A Perspective From the American Contact Dermatitis Society" by Schalock PC, Crawford G, Nedorost S, Scheinman PL, Atwater AR, Mowad C, Brod B, Ehrlich A, Watsky KL, Sasseville D, Silvestri D, Worobec SM, Elliott JF, Honari G, Powell DL, Taylor J, DeKoven J in Dermatitis 27:241-247, 2016. ( 28863114 )
2017
8
Mimicking hypersensitivity pneumonitis as an uncommon initial presentation of chronic granulomatous disease in children. ( 29073922 )
2017
9
Designing Predictive Models for Beta-Lactam Allergy Using the Drug Allergy and Hypersensitivity Database. ( 28739365 )
2017
10
Making Sense of Metal Allergy and Hypersensitivity to Metallic Implants in Relation to Hand Surgery. ( 28709788 )
2017
11
Actinic prurigo as a hypersensitivity reaction type 4. ( 28239837 )
2017
12
Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance. ( 28095394 )
2017
13
Lack of Clinical Hypersensitivity to Penicillin Antibiotics in Common Variable Immunodeficiency. ( 27873106 )
2017
14
Sensitisation to fungi in atopic dermatitis patients over 14A years of age and the relation to the occurrence of food hypersensitivity reactions. ( 28940850 )
2017
15
Nasal interleukin 25 as a novel biomarker for patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness: A pilot study. ( 28870448 )
2017
16
Cyproterone acetate in the treatment of oestrogen hypersensitivity vulvovaginitis. ( 28718897 )
2017
17
Pathologic Separation of Chronic Hypersensitivity Pneumonitis From Fibrotic Connective Tissue Disease-associated Interstitial Lung Disease. ( 28614213 )
2017
18
Systemic contact dermatitis caused by cobalt chloride and palladium in a 26-year-old woman with allergic type I reactions, non-steroidal anti-inflammatory drug hypersensitivity and autoimmune thyroiditis. ( 28951718 )
2017
19
C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress. ( 27037575 )
2017
20
Effect of retrograde colonic electrical stimulation on colonic transit and stress-induced visceral hypersensitivity in rats with irritable bowel syndrome. ( 28942833 )
2017
21
SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. ( 28542600 )
2017
22
Significance of penile hypersensitivity in premature ejaculation. ( 28874780 )
2017
23
Prevalence of Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma at a tertiary care center in North India. ( 28360463 )
2017
24
Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population. ( 28062682 )
2017
25
Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. ( 28747341 )
2017
26
Increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea-predominant irritable bowel syndrome: a preliminary explorative study. ( 27862119 )
2017
27
Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. ( 28054654 )
2017
28
Editorial: increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea-predominant irritable bowel syndrome. ( 28074514 )
2017
29
HDAC inhibitor TSA ameliorates mechanical hypersensitivity and potentiates analgesic effect of morphine in a rat model of bone cancer pain by restoring I1-opioid receptor in spinal cord. ( 28559159 )
2017
30
Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice. ( 28128226 )
2017
31
TLR4 supports the expansion of FasL+CD5+CD1dhi regulatory B cells, which decreases in contact hypersensitivity. ( 28505514 )
2017
32
Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction. ( 29088246 )
2017
33
Th17 Response of Borderline-Lepromatous Leprosy Inhibits Rash Manifestation of Dapsone Hypersensitivity Syndrome: Case Report. ( 28937434 )
2017
34
Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats. ( 29196874 )
2017
35
TrpA1 activation in peripheral sensory neurons underlies the ionic basis of pain hypersensitivity in response to vinca alkaloids. ( 29084244 )
2017
36
Hypersensitivity reaction to I^-lactam antibiotics in patients with adult T-cell leukemia/lymphoma treated with mogamulizumaba8c. ( 28793956 )
2017
37
Hypersensitive termination of the hypoxic response by a disordered protein switch. ( 28273070 )
2017
38
Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis. ( 27956527 )
2017
39
Penicillin Allergy: Mono-, Double-, and Multiple-Drug Hypersensitivity, or Even No Sensitivity? ( 28483320 )
2017
40
Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome. ( 28760966 )
2017
41
Novel insights into the molecular mechanisms underlying generalized glucocorticoid resistance and hypersensitivity syndromes. ( 28742501 )
2017
42
Riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency: delayed hypersensitivity reaction and efficacy of low-dose intermittent supplementation. ( 28643959 )
2017
43
Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer. ( 27169843 )
2017
44
Editorial: increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea-predominant irritable bowel syndrome. Authors' reply. ( 28074518 )
2017
45
Retraction Statement: CXCL12/CXCR4 chemokine signaling in spinal glia induces pain hypersensitivity through MAPKs-mediated neuroinflammation in bone cancer rats. ( 28417467 )
2017
46
Hypersensitivity to azathioprine in a patient with Crohn's disease: a case report. ( 28929775 )
2017
47
Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin-1. ( 26739065 )
2016
48
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS): 11 years retrospective study in Thailand. ( 27134114 )
2016
49
Patch Testing for Evaluation of Hypersensitivity to Implanted Metal Devices: A Perspective From the American Contact Dermatitis Society. ( 27649347 )
2016
50
Chronic prostatitis induces urinary bladder hypersensitivity and sensitizes bladder afferents in the mouse. ( 26997315 )
2016

Variations for Allergic Hypersensitivity Disease

Expression for Allergic Hypersensitivity Disease

Search GEO for disease gene expression data for Allergic Hypersensitivity Disease.

Pathways for Allergic Hypersensitivity Disease

Pathways related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CCL11 EPX FCER2 IFNG IGHE IL10
2
Show member pathways
13.82 CCL11 CCL17 CCR3 HRH4 IL10 IL13
3
Show member pathways
13.67 CCL11 CCL17 CCR3 FCER2 HRH4 IFNG
4
Show member pathways
13.54 CCL11 CCL17 IFNG IL10 IL13 IL4
5
Show member pathways
13.42 CCL11 CCL17 CCR3 HRH4 IL10 IL13
6
Show member pathways
13.4 CCL11 FCER2 IFNG IGHE IL10 IL13
7
Show member pathways
13.34 CCL11 CCL17 CCR3 HRH4 IL10 IL13
8
Show member pathways
12.83 CCL11 EPX IFNG IL10 IL13 IL4
9 12.8 IFNG IL13 IL4 IL5 KITLG
10 12.6 IFNG IL10 IL4 KITLG TLR9 TPT1
11
Show member pathways
12.59 IFNG IL10 IL13 IL4 IL5
12
Show member pathways
12.45 IFNG IL10 IL4 IL5 IL9
13
Show member pathways
12.41 CCL11 FCER2 HRH1 IGHE IL4
14
Show member pathways
12.4 IFNG IL10 IL13 IL4 IL5 IL9
15
Show member pathways
12.39 CCL11 CCL17 IFNG IL13 IL4 IL5
16
Show member pathways
12.2 IFNG IL10 IL13 IL4 IL5 IL9
17
Show member pathways
12.18 CCL11 IFNG IL4 TLR9
18 12.04 CCR3 IFNG IL10 IL4 IL5 KITLG
19 12.01 CCL11 FCER2 IGHE IL10 IL13 IL4
20 11.91 FCER2 IL4 IL5 KITLG
21
Show member pathways
11.87 IFNG IL10 TLR9
22 11.83 IFNG IL13 IL4 IL5
23
Show member pathways
11.81 IFNG IL4 TLR9
24
Show member pathways
11.73 IFNG IL4 IL5
25 11.73 IL10 IL4 IL5 TLR9
26 11.72 CCL11 CCR3 IL13 IL4 IL5
27 11.71 IFNG IL10 TLR9
28 11.7 IFNG IL10 IL13 IL4 IL5 IL9
29 11.59 FCER2 IL10 IL13 IL4
30 11.53 IFNG IL10 TLR9
31 11.5 CCL11 CCL17 FCER2 IGHE IL10 IL4
32 11.37 IFNG IL10 TLR9
33 11.34 IFNG IL4 IL5
34 11.27 IFNG IL13 IL4 IL5 IL9
35 11.18 CCL11 CCL17 IL10 IL13 IL4 IL5
36 11.13 IFNG IL10 IL13 IL4 IL5
37 11.07 CCL11 CCL17 IL10 IL13 IL4 IL5
38 10.89 CCL11 CCL17 IFNG IL10 IL13 IL4
39 10.85 IFNG IL10 IL13 IL4 IL5 IL9
40 10.84 IL13 IL4 IL5 IL9

GO Terms for Allergic Hypersensitivity Disease

Cellular components related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 CCL11 CCL17 EPX IFNG IL10 IL13
2 extracellular region GO:0005576 9.5 CCL11 CCL17 CSN1S1 EPX FCER2 IFNG

Biological processes related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.86 IGHE IL10 RNASE3 TLR9
2 immune response GO:0006955 9.81 CCL11 CCL17 IFNG IGHE IL10 IL13
3 chemotaxis GO:0006935 9.76 CCL11 CCL17 CCR3 IL4
4 chemokine-mediated signaling pathway GO:0070098 9.74 CCL11 CCL17 CCR3
5 positive regulation of endothelial cell proliferation GO:0001938 9.71 CCL11 CCR3 IL10
6 regulation of receptor activity GO:0010469 9.61 CCL11 CCL17 IFNG IL10 IL13 IL4
7 positive regulation of macrophage activation GO:0043032 9.59 IL10 IL13
8 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.58 FCER2 TLR9
9 response to molecule of bacterial origin GO:0002237 9.58 IL10 TLR9
10 positive regulation of B cell proliferation GO:0030890 9.56 IL13 IL4 IL5 TLR9
11 eosinophil chemotaxis GO:0048245 9.55 CCL11 HRH1
12 positive regulation of immunoglobulin production GO:0002639 9.52 IL13 TLR9
13 positive regulation of MHC class II biosynthetic process GO:0045348 9.51 IL10 IL4
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 IL10 IL13 IL4
15 type 2 immune response GO:0042092 9.49 IL10 IL4
16 negative regulation of interleukin-8 production GO:0032717 9.48 IL10 TLR9
17 positive regulation of killing of cells of other organism GO:0051712 9.43 FCER2 IFNG
18 regulation of isotype switching GO:0045191 9.4 IL10 IL4
19 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
20 inflammatory response GO:0006954 9.32 CCL11 CCL17 CCR3 HRH1 HRH4 IL10

Molecular functions related to Allergic Hypersensitivity Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 IL10 IL4 IL5 IL9 KITLG
2 cytokine receptor binding GO:0005126 9.33 IL13 IL4 IL9
3 cytokine activity GO:0005125 9.28 CCL11 CCL17 IFNG IL10 IL13 IL4
4 histamine receptor activity GO:0004969 9.26 HRH1 HRH4

Sources for Allergic Hypersensitivity Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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