MCID: ALL003
MIFTS: 66

Allergic Rhinitis malady

Respiratory diseases, Immune diseases categories

Summaries for Allergic Rhinitis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat red and watery eyes dark circles under the eyes your health care provider may diagnose hay fever based on a physical exam and your symptoms. sometimes skin or blood tests are used. taking medicines and using nasal sprays can relieve symptoms. you can also rinse out your nose, but be sure to use distilled or sterilized water with saline. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases

MalaCards: Allergic Rhinitis, also known as hay fever, is related to rhinitis and allergic asthma. An important gene associated with Allergic Rhinitis is IL13 (interleukin 13), and among its related pathways are PAK Pathway and Rho Family GTPases. The compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

Wikipedia:63 Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as... more...

Description from OMIM:46 607154

Aliases & Classifications for Allergic Rhinitis

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 33MedlinePlus, 9diseasecard, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Aliases & Descriptions:

allergic rhinitis 8 46 10 44 60
hay fever 8 33 60
allergic rhinitis due to animal hair and dander 8
allergic rhinitis, susceptibility to 9
allergic rhinitis due to pollen 8
non-seasonal allergic rhinitis 8
allergic rhinitis due to food 8
seasonal allergic rhinitis 8
perenial allergic rhinitis 8
rhinitis allergic seasonal 44
hay fever - pollens 8
allergy to pollen 8
atopic rhinitis 8
pollenosis 8
pollinosis 8


External Ids:

Disease Ontology8 DOID:4481
NCIt39 C34987
SNOMED-CT56 38103000
OMIM46 607154
ICD1025 J30.1

Related Diseases for Allergic Rhinitis

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17GeneCards, 18GeneDecks
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Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1rhinitis32.4CCL11, SCGB1A1, IGHE, EPX, RNASE3, IL13
2allergic asthma31.7EPX, RNASE3, IL13, IL5, IL9, IL4R
3asthma31.7IL13, SCGB1A1, CCL11
4chronic rhinitis31.2RNASE3, HRH1
5eosinophilia30.9CCL24, CCL11, CCL13, CCR3, IGHE, NGF
6allergic conjunctivitis30.9CCL11, IGHE, RNASE3, IL13, IL5, IL4
7conjunctivitis30.8HRH1, RNASE3, IGHE
8urticaria30.8IGHE, RNASE3, HRH1
9otitis media30.6CCL11, IGHE, RNASE3
10common cold30.5CCL11, RNASE3
11atopic dermatitis30.5CCL11, HRH1, IL4, IL13, RNASE3, NGF
12dermatitis30.5IL5, IL4, IL17A, IL13, IGHE, CCL11
13cystic fibrosis30.3SCGB1A1, RNASE3, CLC, IL9, IL17A
14allergic bronchopulmonary aspergillosis30.3IGHE, IL5, IL4
15giant papillary conjunctivitis30.1CCL11, RNASE3, IL5
16leukemia30.1CCL11, SCGB1A1, NGF, EPX, RNASE3, IL9
17food allergy30.1IL4, IL5, IL13, CCL11, IGHE, EPX
18keratoconjunctivitis30.1CCL11, RNASE3, IL13, IL5
19tuberculosis30.1EPX, IL4R, IL4, IL17A
20graves' disease30.1IL4, IL4R, IL13
21churg-strauss syndrome30.1IL5, RNASE3
22obesity30.1CCL11, IL17A
23allergic urticaria10.6
24vasomotor rhinitis10.5
25neuronitis10.3
26nasopharyngitis10.3
27adenoiditis10.3
28neurodermatitis10.2
29tonsillitis10.2
30aspergillosis10.2
31migraine10.2
32netherton syndrome10.1
33lung cancer10.1
34attention deficit hyperactivity disorder10.1
35pulmonary tuberculosis10.1
36multinodular goiter10.1
37common variable immunodeficiency10.1
38empty sella syndrome10.1
39chronic fatigue syndrome10.1
40klippel-feil syndrome10.1
41cough variant asthma10.1
42osteoporosis10.1
43cervicitis10.1
44goiter10.1
45herpes simplex10.1
46iridocyclitis10.1
47laryngitis10.1
48neonatal jaundice10.1
49sleep disorder10.1
50squamous cell carcinoma10.1

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to allergic rhinitis

Clinical Features for Allergic Rhinitis

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46OMIM
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Clinical features from OMIM:

607154

Drugs & Therapeutics for Allergic Rhinitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Allergic Rhinitis

Drug clinical trials:

Search ClinicalTrials for Allergic Rhinitis

Search NIH Clinical Center for Allergic Rhinitis

Search CenterWatch for Allergic Rhinitis

Genetic Tests for Allergic Rhinitis

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Anatomical Context for Allergic Rhinitis

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32MalaCards
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MalaCards organs/tissues related to Allergic Rhinitis:

32
Skin, Eye, Testes, T cells, Endothelial, B cells, Lung, Bone, Tonsil, Liver, Lymph node, Nk cells, Monocytes, Spleen, Thymus, Heart, Bone marrow

Animal Models for Allergic Rhinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Allergic Rhinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8IGHE, SCGB1A1, HAVCR1, CCR3, CCL11, CCL24
2MP:000539711.6CCL24, CCL11, CCR3, HAVCR1, IGHE, EPX
3MP:000538811.6IL17A, CCL24, CCL11, CCR3, FOXJ1, HAVCR1
4MP:000537611.2CCR3, SCGB1A1, IGHE, NGF, IL13, IL5
5MP:000538111.1IL13, IL5, IL9, IL4R, IL4, IL17A

Publications for Allergic Rhinitis

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50PubMed
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Articles related to Allergic Rhinitis:

(show top 50)    (show all 1181)
idTitleAuthorsYear
1
Comparison of mometasone furoate monohydrate (Nasonex) and fluticasone propionate (Flixonase) nasal sprays in the treatment of dust mite-sensitive children with perennial allergic rhinitis. (23597528)
2013
2
A phase 3 trial assessing the efficacy and safety of grass allergy immunotherapy tablet in subjects with grass pollen-induced allergic rhinitis with or without conjunctivitis, with or without asthma. (23725348)
2013
3
Acupuncture in patients with seasonal allergic rhinitis: a randomized trial. (23420231)
2013
4
Recognition of allergic conjunctivitis in patients with allergic rhinitis. (23663473)
2013
5
Classification of Allergic Rhinitis: What is Most Suitable in Korea? (23451334)
2013
6
Symptom score for allergic rhinitis. (23429039)
2013
7
Prevalence of asthma and severity of allergic rhinitis comparing 2 perennial allergens: house dust mites and Parietaria judaica pollen. (23967752)
2013
8
Frequency of genetic polymorphisms of ADAM33 and their association with allergic rhinitis among Jordanians. (24035932)
2013
9
Control of Allergic Rhinitis and Asthma Test (CARAT): dissemination and applications in primary care. (23412110)
2013
10
A critical role of IL-33 in experimental allergic rhinitis. (22460070)
2012
11
An overview of the novel H1-antihistamine bilastine in allergic rhinitis and urticaria. (22149338)
2012
12
AAT polymorphisms in intron 20 of NOS1 confer vulnerability to mite-induced allergic rhinitis in Chinese patients. (22448456)
2012
13
Re: Endonasal phototherapy for the treatment of allergic rhinitis/hay fever. (22515718)
2012
14
A trial of adding Lactobacillus johnsonii EM1 to levocetirizine for treatment of perennial allergic rhinitis in children aged 7-12 years. (22513081)
2012
15
Quality of life and control of allergic rhinitis in patients from regions beyond western Europe and the United States. (23181786)
2012
16
Correlation between nasal resistance and different acoustic rhinometry parameters in children and adolescents with and without allergic rhinitis. (23306573)
2012
17
Tissue-specific effects of allergic rhinitis in mouse nasal epithelia. (22490702)
2012
18
Efficacy of sublingual swallow immunotherapy in children with rye grass pollen allergic rhinitis: a double-blind placebo-controlled study. (22761191)
2012
19
Allergic rhinitis and associated factors in schoolchildren from Bogota, Colombia. (22616072)
2012
20
Validating childhood symptoms with physician-diagnosed allergic rhinitis. (22469440)
2012
21
Association of the CD14 gene polymorphism C-159T with allergic rhinitis. (20109306)
2010
22
Serum transforming growth factor-beta levels depend on allergen exposure in allergic rhinitis. (19940507)
2010
23
High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. (19833116)
2010
24
Serum interleukin 9 in allergic rhinitis. (20306823)
2010
25
Nerve growth factor localization in the nasal mucosa of patients with persistent allergic rhinitis. (19076929)
2009
26
Anti-IgE for the treatment of allergic rhinitis--and eventually nasal polyps? (18799888)
2009
27
Relationship between the IL-12B promoter polymorphism and allergic rhinitis, familial asthma, serum total IgE, and eosinophil level in asthma patients. (19274925)
2009
28
A study of costimulatory molecules in allergic allergic rhinitis patients]. (19086656)
2008
29
Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis. (19209282)
2008
30
Correlation between specific IgA and eosinophil numbers in the lavage fluid of patients with perennial allergic rhinitis. (18430312)
2008
31
The results of specific immunotherapy for house dust mites in patients with allergic rhinitis]. (18628641)
2008
32
Relationship between GATA-3 and IL-12 in patients with allergic rhinitis]. (18260379)
2007
33
Effects of pollen and nasal glucocorticoid on FOXP3+, GATA-3+ and T-bet+ cells in allergic rhinitis. (17686103)
2007
34
Expression of Syk is associated with nasal polyp in patients with allergic rhinitis. (17141440)
2007
35
Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity. (16892784)
2006
36
Regulation of the expression of interleukin-4 and interleukin-5 by the signal pathway of PKC-NF-kappaB in T lymphocyte of allergic rhinitis]. (16722389)
2006
37
Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. (15814733)
2005
38
Association of a haplotype block spanning SDAD1 gene and CXC chemokine genes with allergic rhinitis. (15753903)
2005
39
Identification of missense mutation in the IL12B gene: lack of association between IL12B polymorphisms and asthma and allergic rhinitis in the Japanese population. (11704807)
2001
40
Nasal interleukin-5, immunoglobulin E, eosinophilic cationic protein, and soluble intercellular adhesion molecule-1 in chronic sinusitis, allergic rhinitis, and nasal polyposis. (10852530)
2000
41
Determination of the immune function of the erythrocyte and leucocyte and the activity of IL-4 and IFN-gamma in patients with allergic rhinitis]. (12768759)
2000
42
Circulating eosinophil/basophil progenitors and nasal mucosal cytokines in seasonal allergic rhinitis. (10321556)
1999
43
The effect of immunotherapy on the serum levels of eosinophil cationic protein in seasonal allergic rhinitis. (9160918)
1997
44
Immunotherapy affects the seasonal increase in specific IgE and interleukin-4 in serum of patients with seasonal allergic rhinitis. (9246210)
1997
45
Chemokines in seasonal allergic rhinitis. (8568122)
1996
46
Eosinophil inflammation of the nasal mucosa in allergic and non-allergic rhinitis measured by eosinophil cationic protein levels in native nasal fluid and serum. (7889429)
1994
47
Humoral response to subcutaneous, oral, and nasal immunotherapy for allergic rhinitis due to Dermatophagoides pteronyssinus. (7755664)
1993
48
Human basophil releasability. VI. Changes in basophil releasability in patients with allergic rhinitis or bronchial asthma. (1700653)
1990
49
Circulating immunoglobulin E (IgE) antibodies to L-thyroxine in a euthyroid patient with multinodular goiter and allergic rhinitis. (6715795)
1984
50
Diphenylpyraline (Lergobine) in the treatment of patients suffering from allergic and vasomotor rhinitis. (14039)
1977

Genetic Variations for Allergic Rhinitis

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Expression for genes affiliated with Allergic Rhinitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Rhinitis

Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for genes affiliated with Allergic Rhinitis

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.3CCL24, IL4, IL4R, IL9, IL5, IL13
2
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11.3CCL24, CCL11, CCL13, CCR3, IL13, IL5
3
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11.3IL4R, IL9, IL5, IL13, CCR3, CCL13
4
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11.2CCL11, EPX, RNASE3, IL13, IL5, IL9
5
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11.2CCL24, CCL11, CCL13, IL13, IL5, IL9
6
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11.2CCL24, CCL11, CCR3, IL13, IL5, IL9
7
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11.0CCL11, IGHE, IL13, IL5, IL4R, IL4
810.9IL4, IL4R, IL9, IL5, IL13
910.9IL13, IL5, IL9, IL4R, IL4
10
Hide members
10.9IL17A, IL4, IL4R, IL5, IL13
1110.9CCL11, IGHE, IL5, IL4R, IL4
1210.8IL13, IL5, IL9, IL4
1310.8IL13, IL5, IL9, IL4
14
Hide members
10.8IL5, IL9, IL4, IL17A
15
Immune response CCR3 signaling in eosinophils
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10.8CCR3, CCL13, CCL11, CCL24
16
Hide members
10.8CCL24, CCL11, CCL13, CCR3
1710.8IL4, IL5, IL13
1810.8CCL11, IL5, IL4
1910.8IL4, IL4R, IL5
2010.8IL5, IL4R, IL4
21
Hide members
10.8IL17A, IL4, IL4R

Compounds for genes affiliated with Allergic Rhinitis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2414.2IL5, CCL24, CCL11, CCL13, CCR3, IGHE
2dexamethasone44 49 28 1115.1CCL11, CCR3, IGHE, NGF, EPX, RNASE3
3tyrosine4411.9IL4R, HAVCR1, NGF, CCR3, CCL11, IL13
4allergens4411.8CCL11, HRH1, RNASE3, IL4, IGHE, EPX
5tarc4411.8IL9, CCL24, CCL11, IL4, IL4R, IL5
6cyclosporin a44 28 5913.8IL13, CCL11, IGHE, NGF, RNASE3, HRH1
7thymidine44 2412.8CCR3, CCL11, IL13, IL5, HRH1, NGF
8actinomycin d4411.7IL4R, NGF, IGHE, CCR3, CCL11, CCL24
9methacholine44 1112.7CCL11, IGHE, IL17A, IL4, IL9, RNASE3
10steroid4411.6IL4R, RNASE3, IL17A, EPX, CCL11, CCL13
11rantes4411.6CCL11, RNASE3, IL9, IL4R, IL4, IL17A
12budesonide44 49 1113.6IL5, IL13, RNASE3, IL4, IGHE, CCL11
13pgd24411.6IGHE, IL5, IL13, RNASE3, CCR3, CCL11
14prednisolone44 28 1113.5RNASE3, EPX, NGF, IGHE, CCL11, IL5
15ionomycin4411.5IL9, IL5, IL13, IL17A, IL4, CCL11
16adenylate4411.5IGHE, HRH1, IL4, IL5, IL13, RNASE3
17sodium cromoglycate4411.5EPX, CCL11, IGHE, HRH1, IL5, RNASE3
18cetirizine44 28 11 2414.5CCL11, HRH1, IL5, RNASE3, EPX, IGHE
19salmeterol44 49 28 1114.5EPX, CCL11, IL4, RNASE3, IL13, IL5
20montelukast44 49 28 1114.5IL4, IL5, IL13, IGHE, CCL11, RNASE3
21ketotifen44 1112.5HRH1, RNASE3, EPX, IGHE, CCL11, IL5
22salbutamol44 49 28 11 2415.4CCL11, IGHE, EPX, RNASE3, IL13, IL5
23fluticasone propionate44 49 59 1114.4CCL11, IGHE, RNASE3, IL13, IL4, IL5
24nedocromil sodium4411.3IL5, HRH1, IL4, RNASE3, IGHE
25praziquantel44 1112.3IL13, IL4, IL5, IGHE, RNASE3
26azelastine44 1112.3IL5, RNASE3, IGHE, HRH1, IL4
27ltd44411.3HRH1, IL5, IL13, RNASE3, CCR3
28ltc44411.3CCL11, EPX, IL5, IL13, RNASE3
29vegf4411.3IL4, IGHE, IL13, IL5, NGF, IL17A
30tacrolimus44 49 1113.2CCL11, IL13, IL17A, IL4, IL5, HRH1
31unicap4411.2IL5, IGHE, CCL11, RNASE3
32omalizumab44 1112.2IL5, IGHE, IL13, IL4
33capsaicin44 2812.2RNASE3, NGF, IGHE, IL5, HRH1
34anti-histamine4411.2CCL11, IGHE, RNASE3, HRH1
35lte44411.2CCL11, IL5, EPX, RNASE3
36aspirin44 49 28 2414.2HRH1, CCL11, IL13, IL4, RNASE3, NGF
37desloratadine44 1112.2IL4, HRH1, IL13, IGHE
38theophylline44 28 11 2414.2IL13, IL5, EPX, RNASE3, NGF
39indomethacin44 59 28 1114.1NGF, IL5, HRH1
40pranlukast44 28 1113.1CCL11, RNASE3, IL5, IL4
41leukotriene b444 59 2413.1IL5, IL13, RNASE3, EPX, CCL11
42sb 20358044 5912.0IL13, IL5, IL4, IL17A, CCL11, NGF
43endotoxin4411.0RNASE3, HRH1, SCGB1A1
44pge24411.0EPX, CCL11
45levocetirizine4410.9CCL11, IL4, HRH1
46ovomucoid4410.9IGHE
47rolipram44 59 2812.9EPX
48creatinine4410.8NGF, RNASE3, IGHE, HRH1, EPX, SCGB1A1
49oxatomide4410.8HRH1, IGHE, IL5
50levocabastine44 28 1112.7RNASE3, IL5, HRH1

GO Terms for genes affiliated with Allergic Rhinitis

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16Gene Ontology
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Cellular components related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.6IL17A, CCL11, CCL13, CCR3, SCGB1A1, NGF

Biological processes related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.7HRH1, CCL24, CCL11, CCL13, CCR3, NGF
2immune responseGO:00695511.7CCL24, CCL11, CCL13, IGHE, IL13, IL5
3eosinophil chemotaxisGO:04824511.2CCL24, CCL11, CCL13, CCR3, HRH1
4chemotaxisGO:00693511.2CCL24, CCL11, CCL13, CCR3, IL4
5signal transductionGO:00716511.1CCL24, CCL11, CCL13, SCGB1A1, IL13, IL4R
6positive regulation of B cell proliferationGO:03089011.0IL4, IL5, IL13
7cell-cell signalingGO:00726711.0CCL24, CCL13, IL13, IL17A
8positive regulation of endothelial cell proliferationGO:00193811.0CCR3, CCL11, CCL24
9response to ozoneGO:01019310.9SCGB1A1, NGF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.9IL4, IL5, NGF
11negative regulation of interleukin-5 productionGO:03271410.9SCGB1A1, EPX
12regulation of proton transportGO:01015510.9IL13, IL4
13mast cell chemotaxisGO:00255110.9CCL11, CCR3
14positive regulation of angiogenesisGO:04576610.8CCR3, CCL11, CCL24
15positive regulation of macrophage activationGO:04303210.8IL13, IL4R
16response to lipopolysaccharideGO:03249610.8IL13, NGF, SCGB1A1
17cytoskeleton organizationGO:00701010.8CCL24, CCL11, CCL13
18regulation of cell shapeGO:00836010.7CCL13, CCL11, CCL24
19defense response to protozoanGO:04283210.4IL4, IL4R

Molecular functions related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.8IL17A, IL4, IL9, IL5, IL13
2chemokine activityGO:00800910.8CCL13, CCL11, CCL24
3growth factor activityGO:00808310.5NGF, IL5, IL9, IL4

Products for genes affiliated with Allergic Rhinitis

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  • Antibodies
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Sources for Allergic Rhinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet