ALRH
MCID: ALL003
MIFTS: 63

Allergic Rhinitis (ALRH) malady

Categories: Genetic diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Allergic Rhinitis

Aliases & Descriptions for Allergic Rhinitis:

Name: Allergic Rhinitis 54 12 66 29 52 14 69
Hay Fever 12 41 14 69
Rhinitis, Allergic, Perennial 42 69
Atopic Rhinitis 12 69
Allergic Rhinitis, Susceptibility to 13
Non-Seasonal Allergic Rhinitis 12
Rhinitis, Allergic, Seasonal 42
Perenial Allergic Rhinitis 12
Seasonal Allergic Rhinitis 12
Rhinitis Allergic Seasonal 52
Pollenosis 12
Alrh 66

Classifications:



External Ids:

OMIM 54 607154
Disease Ontology 12 DOID:4481
NCIt 47 C34987
SNOMED-CT 64 38103000
MedGen 40 C2607914
ICD10 33 J30.1
UMLS 69 C0002103

Summaries for Allergic Rhinitis

MedlinePlus : 41 each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat red and watery eyes dark circles under the eyes your health care provider may diagnose hay fever based on a physical exam and your symptoms. sometimes skin or blood tests are used. taking medicines and using nasal sprays can relieve symptoms. you can also rinse out your nose, but be sure to use distilled or sterilized water with saline. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases

MalaCards based summary : Allergic Rhinitis, also known as hay fever, is related to urticaria and pulmonary tuberculosis, and has symptoms including coughing, snoring and sore throat. An important gene associated with Allergic Rhinitis is IL13 (Interleukin 13), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Allegra and Allegra-D have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

UniProtKB/Swiss-Prot : 66 Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.

Wikipedia : 71 Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose which occurs when the... more...

Description from OMIM: 607154

Related Diseases for Allergic Rhinitis

Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
id Related Disease Score Top Affiliating Genes
1 urticaria 30.1 ALOX5 KNG1 MPO
2 pulmonary tuberculosis 29.4 CCL11 CXCL8 IGHE IL13 IL4 IL4R
3 atopy 11.3
4 rhinitis 11.3
5 pollen allergy 11.1
6 asthma-related traits 4 11.0
7 asthma 10.8
8 vasomotor rhinitis 10.8
9 mucositis 10.4
10 dahlberg borer newcomer syndrome 10.3 IL13 IL5
11 renal hypertension 10.3 IL13 IL5 RNASE3
12 anterior dislocation of lens 10.3 CCL11 IL4 RNASE3
13 crustacean allergy 10.3 IL13 IL4 IL4R
14 spastic diplegia 10.3 CCL11 IL13 IL5
15 goat milk allergy 10.3 IL13 IL4 IL4R
16 disordered steroidogenesis due to cytochrome p450 oxidoreductase 10.3 CCL11 IL13 IL5
17 lens-induced iridocyclitis 10.3 IL4 IL5 RNASE3
18 papillary squamous carcinoma 10.3 IGHE IL4 IL5
19 bone peripheral neuroepithelioma 10.3 IL13 IL4 IL5
20 restrictive cardiomyopathy 10.3 IL5 RNASE3
21 indian plum allergy 10.3 IL13 IL4 IL5
22 lactose intolerance 10.3 IL13 IL4 IL5
23 askin's tumor 10.3 IL13 IL4 IL5
24 appendix carcinoid tumor 10.3 EPX NGF RNASE3
25 cutaneous fibrous histiocytoma 10.3 CCL11 IL4 IL5
26 peptidic growth factors deficiency 10.3 CCL11 IL5
27 psychotic disorder 10.3 CCL11 CXCL8 IL4
28 allergic asthma 10.3
29 isolated klippel-feil syndrome 10.3 IGHE IL4 IL5
30 orbit alveolar rhabdomyosarcoma 10.3 IL4 IL5 RNASE3
31 infectious anterior uveitis 10.3 CXCL8 IL5 RNASE3
32 retinal vascular disease 10.3 CCL11 CXCL8 IL4
33 lissencephaly with cerebellar hypoplasia 10.3 IGES IGHE
34 duodenal somatostatinoma 10.3 IL13 IL4 IL5
35 childhood malignant mesenchymoma 10.3 CCL11 IL13 IL5 RNASE3
36 amelogenesis imperfecta 1j 10.3 EPX RNASE3
37 dissociated nystagmus 10.3 EPX IL4 IL5
38 breast intracanalicular fibroadenoma 10.3 CXCL8 IL4 IL5
39 lymphangiectasia, intestinal 10.3 IL4 NGF RNASE3
40 wilkes stevenson syndrome 10.2 CXCL8 IL5 RNASE3
41 cerebral primitive neuroectodermal tumor 10.2 CCL11 IL4 IL5 RNASE3
42 thelaziasis 10.2 CCL11 IL13 IL4 IL5
43 sinusitis 10.2
44 lymphoblastic leukemia 10.2 CCL11 IL13 IL4 IL5
45 allergic hypersensitivity disease 10.2
46 chromophobe adenoma 10.2 CXCL8 ICAM1
47 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.2 IGHE IL4 IL5 RNASE3
48 dengue hemorrhagic fever 10.2 IL13 IL4 IL5
49 lymphocytic gastritis 10.2 CCL11 IL13 IL4 IL5
50 actinic keratosis 10.2 IL13 IL4 IL5 RNASE3

Comorbidity relations with Allergic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Disorder Bronchitis
Esophagitis Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to Allergic Rhinitis

Symptoms & Phenotypes for Allergic Rhinitis

Clinical features from OMIM:

607154

UMLS symptoms related to Allergic Rhinitis:


coughing, snoring, sore throat, vertigo/dizziness, equilibration disorder, rhinorrhea

MGI Mouse Phenotypes related to Allergic Rhinitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 ALOX5 CCL11 EPX HRH1 ICAM1 IL13
2 immune system MP:0005387 9.36 HRH1 ICAM1 IL13 IL4 IL4R IL5

Drugs & Therapeutics for Allergic Rhinitis

FDA approved drugs:

(show all 19)
id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Allegra 17 FEXOFENADINE HYDROCHLORIDE Hoechst Marion Roussel Approved July 1996
2
Allegra-D 17 FEXOFENADINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE Hoechst Marion Roussel Approved March 1998
3
Astelin nasal spray 17 AZELASTINE HYDROCHLORIDE Wallace Laboratories Approved November 1996
4
Atrovent 17 IPRATROPIUM BROMIDE Boehringer Ingelheim Approved January 1996
5
Clarinex 17 DESLORATADINE Schering-Plough Approved February 2002
6
Claritin RediTabs 17 LORATADINE Schering-Plough Approved January 1997
7
Clemastine fumarate syrup 17 CLEMASTINE FUMARATE Morton Grove Pharmaceuticals Approved March 1998
8
Dymista 17 AZELASTINE HYDROCHLORIDE; FLUTICASONE PROPIONATE Meda Pharmaceuticals Inc Approved May 2012
9
Flonase Nasal Spray 17 FLUTICASONE PROPIONATE GlaxoSmithKline Approved November 1997
10
Grastek 17 Timothy Grass Pollen Allergen Extract Merck Approved April 2014
11
Nasacort AQ Nasal Spray 17 TRIAMCINOLONE ACETONIDE Phone-Poulenc Rorer Approved October 1997
12
Oralair 17 Greer Labs Approved April 2014
13
Patanase 17 OLOPATADINE HYDROCHLORIDE Alcon Approved April 2008
14
Qnasl 17 BECLOMETHASONE DIPROPIONATE Teva Pharmaceutical Approved March 2012
15
Ragwitek 17 Merck Approved April 2014
16
Rhinocort Aqua Nasal Spray 17 BUDESONIDE AstraZeneca Approved October 1999
17
Tri-Nasal Spray 17 Muro Pharmaceutical Approved February 2000
18
Xyzal 17 LEVOCETIRIZINE DIHYDROCHLORIDE UCB Approved May 2007
19
Zyrtec 17 CETIRIZINE HYDROCHLORIDE Pfizer Approved December 1995

Drugs for Allergic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 341)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 4 10102-43-9 145068
2
Montelukast Approved Phase 4,Phase 3,Phase 2,Phase 1 158966-92-8 5281040
3
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
4
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
5
Phenylephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 59-42-7 6041
6
Oxymetazoline Approved Phase 4,Phase 3,Phase 2,Phase 1 1491-59-4 4636
7
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
8
Capsaicin Approved Phase 4 404-86-4 1548943
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
10
Azelastine Approved Phase 4,Phase 3,Phase 2,Phase 1 58581-89-8 2267
11
Budesonide Approved Phase 4,Phase 3,Phase 2 51333-22-3 63006 5281004
12
Levocetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 130018-77-8
13
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 83881-51-0 2678
14
Loratadine Approved Phase 4,Phase 3,Phase 2 79794-75-5 3957
15
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2 100643-71-8 124087
16
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 1 242138-07-4
17
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
18
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
19
Xylometazoline Approved Phase 4 526-36-3 5709
20
Theophylline Approved Phase 4,Phase 2 58-55-9 2153
21
Fexofenadine Approved Phase 4,Phase 3,Phase 2,Phase 1 83799-24-0 3348
22
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 1 51-43-4 5816
23
Prazosin Approved Phase 4 19216-56-9 4893
24
Doxazosin Approved Phase 4 74191-85-8 3157
25
Glycerol Approved, Experimental Phase 4,Phase 3,Phase 1,Phase 2 56-81-5 753
26
Adenosine Approved, Investigational Phase 4 58-61-7 60961
27
Diphenhydramine Approved Phase 4,Phase 3,Phase 1 58-73-1, 147-24-0 3100
28
Tranilast Approved, Investigational Phase 4 53902-12-8 93543
29
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
30
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
31
Epinastine Approved, Investigational Phase 4,Phase 3,Phase 2 80012-43-7 3241
32
Promethazine Approved Phase 4,Phase 3,Phase 1 60-87-7 4927
33
Ciclesonide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 126544-47-6, 141845-82-1 444033
34
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
35
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 6447131 17753757
36
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 6221 10883523 5280795
37
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
38 vitamin d Phase 4,Phase 2,Phase 3
39 mometasone furoate Phase 4,Phase 3,Phase 2,Phase 1 83919-23-7
40 Prednisolone acetate Phase 4,Phase 3
41 Betamethasone Valerate Phase 4,Phase 3 2152-44-5
42
Histamine Phosphate Phase 4,Phase 3,Phase 2,Phase 1 51-74-1 65513
43
Beclomethasone Phase 4,Phase 3,Phase 2,Phase 1 4419-39-0 20469
44
Fluticasone Phase 4,Phase 3,Phase 2,Phase 1 90566-53-3, 80474-14-2 62924 22833648
45 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
46 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
47 Cholinergic Agents Phase 4,Phase 3,Phase 2
48 Mydriatics Phase 4,Phase 3,Phase 2,Phase 1
49 Cholinergic Antagonists Phase 4,Phase 3,Phase 2
50 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 969)
id Name Status NCT ID Phase
1 Efficacy of Allergen Immunotherapy for Allergic Rhinitis in Thais Unknown status NCT01115595 Phase 4
2 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4
3 Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites Unknown status NCT01052610 Phase 4
4 Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4
5 Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis Unknown status NCT00488176 Phase 4
6 Cosalin® Monotherapy Versus Cosalin® and Xarlin® Combination Therapy Unknown status NCT01062139 Phase 4
7 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Unknown status NCT00560586 Phase 4
8 POLlinosis and Exhaled Breath Temperature Unknown status NCT01785394 Phase 4
9 Comparison of Effectiveness and Safety of Sublingual Immunotherapy in Children With Allergic Rhinitis Completed NCT00698594 Phase 4
10 Anti-inflammatory H1 Antihistamines Allergic Rhinitis Completed NCT02507635 Phase 4
11 Sunovion Growth Study Pediatric Subjects With Mild Asthma & Allergic Rhinitis Completed NCT01550471 Phase 4
12 Assessment of Intranasal Steroids in Allergic Rhinitis When Used Alone or in Combination With an Oral Antihistamine (Study P03270) Completed NCT00834119 Phase 4
13 A Clinical Study To Test A Nasal Spray (Fluticasone Furoate Nasal Spray) For The Treatment Of Perennial (Year-round) Allergic Rhinitis Completed NCT00609674 Phase 4
14 Quality of Life in Patients With Allergic Rhinitis: Clinical Trial With Bilastine or Loratadine Completed NCT02513290 Phase 4
15 Study of Triamcinolone Acetonide on the Growth Velocity of Children, Ages 3 to 9, With Perennial Allergic Rhinitis (PAR) Completed NCT00449072 Phase 4
16 A Clinical Study With Fluticasone Furoate Nasal Spray And Vehicle Placebo For The Treatment Of Perennial (Year-round) Allergic Rhinitis Completed NCT00682643 Phase 4
17 Efficacy and Safety of Lectranal® in Treatment of Seasonal Allergic Rhinitis Symptoms Completed NCT00460538 Phase 4
18 Investigation of the Efficacy and Safety of Concomitant Administration of Ciclesonide Nasal Spray and Azelastine Nasal Spray in Patients (18 Years or Older) With Perennial Allergic Rhinitis (PAR) Not Adequately Controlled on an Intranasal Corticosteroid o Completed NCT00806754 Phase 4
19 Levocetirizine 5 mg: Reduction of Symptoms, Airway Resistance and Sleep Impairment in Persistent Allergic Rhinitis Completed NCT00355771 Phase 4
20 Montelukast in Mild Asthmatic Children With Allergic Rhinitis (0476-367) Completed NCT00442559 Phase 4
21 ATAREAL (Antihistamine Treatment for Allergic Rhinitis in Real Life) Completed NCT00160680 Phase 4
22 Montelukast and Fexofenadine Versus Montelukast and Levocetrizine Combination in Allergic Rhinitis Completed NCT02551536 Phase 4
23 A Phase-IV, Open-label Study to Evaluate Safety/Tolerability of Once-daily AVAMYS (TM) Aqueous Nasal Spray 110mcg Among Vietnamese Adult Patients With Established Perennial Allergic Rhinitis Completed NCT01270958 Phase 4
24 POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis) Completed NCT00160537 Phase 4
25 Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial Completed NCT00691665 Phase 4
26 LEADER (LEvocetirizine And DEsloratadine in Allergic Rhinitis) Completed NCT00160589 Phase 4
27 To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis Completed NCT00679250 Phase 4
28 Fexofenadine Study On Filipino Children for The Relief of Perennial And Intermittent Allergic Rhinitis Completed NCT00741897 Phase 4
29 Efficacy and Safety of Levocetirizine and Fexofenadine in Reducing Symptoms of Seasonal Allergic Rhinitis Completed NCT00542607 Phase 4
30 Safety Study of MK-3641 and MK-7243 Co-administered in Adult Participants With Ragweed and Grass Pollen Induced Allergic Rhinitis (P08607, MK-3641-006) Completed NCT02256553 Phase 4
31 Children, Perennial Allergic Rhinitis (PAR), l-t Growth Completed NCT00641212 Phase 4
32 Nasacort AQ Hypothalamic-Pituitary-Adrenal (HPA) Axis Study in Children With Allergic Rhinitis Completed NCT01154153 Phase 4
33 Fluticasone and Salmeterol in Allergic Rhinitis Completed NCT01388595 Phase 4
34 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed NCT00621959 Phase 4
35 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed NCT00653224 Phase 4
36 Efficacy and Tolerability of a Topical Microemulsion in Patients With Allergic Rhinitis Due to Sensitization to Pollen Completed NCT01478425 Phase 4
37 Effects of Long-Term Treatment With Nasally Inhaled Triamcinolone Acetonide in Children With Allergic Rhinitis Completed NCT00189449 Phase 4
38 Comparison of the Effects of Nasal Steroids and Montelukast on Olfactory Functions in Patients With Allergic Rhinitis Completed NCT02565212 Phase 4
39 Alpha-Blockers in Allergic Rhinitis (MAN 01) Completed NCT01946035 Phase 4
40 Safety of PATANASE Nasal Spray in Patients With Perennial Allergic Rhinitis Completed NCT00789555 Phase 4
41 Nasal Budesonide Efficacy on Nasal FeNO in Children With Allergic Rhinitis Completed NCT02409563 Phase 4
42 Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis Completed NCT00894231 Phase 4
43 Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Uni Completed NCT00637611 Phase 4
44 Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis Completed NCT01326247 Phase 4
45 A Comparator Study of Fluticasone Propionate Nasal Spray Verses (vs) Cetirizine in the Treatment of Seasonal Allergic Rhinitis Completed NCT01916226 Phase 4
46 A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis Completed NCT00561717 Phase 4
47 Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With AR. RinASol- Pilot Study Completed NCT02729012 Phase 4
48 Allergic Rhinitis Changes the Sinus Microbiome Completed NCT01852513 Phase 4
49 Efficacy & Safety of Loratadine-Betamethasone Oral Solution for Treatment of Severe Perennial Allergic Rhinitis in Children (Study P03428) Completed NCT00963573 Phase 4
50 Onset of Effect of Mometasone Nasal Spray in Induced Allergic Rhinitis (Study P03431) Completed NCT00783237 Phase 4

Search NIH Clinical Center for Allergic Rhinitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rhinitis, allergic, seasonal

Genetic Tests for Allergic Rhinitis

Genetic tests related to Allergic Rhinitis:

id Genetic test Affiliating Genes
1 Allergic Rhinitis 29

Anatomical Context for Allergic Rhinitis

MalaCards organs/tissues related to Allergic Rhinitis:

39
Eye, Testes, Skin, T Cells, Neutrophil, Brain, B Cells

Publications for Allergic Rhinitis

Articles related to Allergic Rhinitis:

(show top 50) (show all 1325)
id Title Authors Year
1
Effects of CPAP in patients with obstructive apnoea: is the presence of allergic rhinitis relevant? ( 28493047 )
2017
2
Allergic Rhinitis in Preschool Children and the Clinical Utility of FeNO. ( 28497918 )
2017
3
EXPERIMENTAL EVIDENCES FOR LOCAL ALLERGIC RHINITIS. ( 28515398 )
2017
4
Effect of nasal allergen challenge in allergic rhinitis on mitochondrial function of peripheral blood mononuclear cells. ( 28073613 )
2017
5
Allergen immunotherapy for the treatment of allergic rhinitis and/or asthma: an umbrella review. ( 28495938 )
2017
6
Allergen immunotherapy in allergic rhinitis: Current use and future trends. ( 28532268 )
2017
7
Associations of single nucleotide polymorphisms of PTPN22 and Ctla4 genes with the risk of allergic rhinitis in a Chinese Han population. ( 27888068 )
2017
8
Basophil activation test for inhalant allergens in pediatric patients with allergic rhinitis. ( 28483235 )
2017
9
Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis. ( 28497614 )
2017
10
The pharmacotherapy preferred by doctors in treatment of patients diagnosed with asthma or chronic obstructive pulmonary disease or allergic rhinitis and concomitant diseases: an epidemiological analysis. ( 28507495 )
2017
11
PHENOTYPE OF ALLERGIC RHINITIS AND RHINOSINUSITIS. ( 28515393 )
2017
12
Effect of the external nasal dilator on adolescent athleteswith and without allergic rhinitis. ( 28483221 )
2017
13
T-helper 2 cytokine-induced heat shock protein 70 secretion and its potential association with allergic rhinitis. ( 28054753 )
2017
14
Regional Difference of Causative Pollen in Children with Allergic Rhinitis. ( 28480649 )
2017
15
Management of allergic rhinitis in the era of effective over-the-counter treatments. ( 28532204 )
2017
16
The role of vitamin D in allergic rhinitis. ( 28487837 )
2017
17
Self-assessment of Allergic Rhinitis and Asthma (SACRA) Questionnaire-based Allergic Rhinitis Treatment Improves Asthma Control in Asthmatic Patients with Allergic Rhinitis. ( 28049997 )
2017
18
Kinetic oscillatory stimulation of nasal mucosa in non-allergic rhinitis: comparison of patient self-administration and caregiver administration regarding pain and treatment effect. A randomized clinical trial. ( 28498078 )
2017
19
Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with IL13 rs20541 Polymorphism in Finnish Adult Asthma Patients. ( 28273659 )
2017
20
Pilot study of mobile phone technology in allergic rhinitis in European countries. The MASK-rhinitis study. ( 28072463 )
2017
21
Allergen Immunotherapy for a Teenager with Seasonal Allergic Rhinitis Due to Grass Pollen: Subcutaneous or Sublingual Route? ( 28065341 )
2017
22
Mapping and comparing bacterial microbiota in the sinonasal cavity of healthy, allergic rhinitis, and chronic rhinosinusitis subjects. ( 28481057 )
2017
23
Effectiveness of quercetin in an experimental rat model of allergic rhinitis. ( 28493194 )
2017
24
"Allergic mood" - Depressive and anxiety symptoms in patients with seasonal allergic rhinitis (SAR) and their association to inflammatory, endocrine, and allergic markers. ( 28495610 )
2017
25
Role of Interleukin-17A on the Chemotactic Responses to CCL7 in a Murine Allergic Rhinitis Model. ( 28046055 )
2017
26
Non-Allergic Rhinitis: Position paper of the European Academy of Allergology and Clinical Immunology. ( 28474799 )
2017
27
A functional variant of miRNA-149 confers risk for allergic rhinitis and comorbid asthma in Chinese children. ( 28181414 )
2017
28
Association of pediatric allergic rhinitis with the ratings of attention-deficit/hyperactivity disorder. ( 28490400 )
2017
29
Correlation between Serum Osteopontin and miR-181a Levels in Allergic Rhinitis Children. ( 27199509 )
2016
30
The Prevalence of Allergic Rhinitis, Eczema and Asthma in Students of Guidance Schools in Mazandaran Province, Iran. ( 28028401 )
2016
31
Semi-depot house-dust mite allergen extract for Chinese with allergic rhinitis and asthma. ( 27216351 )
2016
32
Suppression of neuropeptide production by quercetin in allergic rhinitis model rats. ( 27207147 )
2016
33
Allergic rhinitis, rhinoconjunctivitis and eczema: Prevalence and associated factors in children. ( 27663282 )
2016
34
Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis. ( 27188226 )
2016
35
A Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels. ( 26792385 )
2016
36
Long-term safety of replication-defective smallpox vaccine (MVA-BN) in atopic eczema and allergic rhinitis. ( 27357167 )
2016
37
Gene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis. ( 26316419 )
2016
38
Genetic variations in interleukin-12B in allergic rhinitis. ( 26663019 )
2016
39
Does adenoid hypertrophy affect disease severity in children with allergic rhinitis? ( 27405740 )
2016
40
Health care resource use and associated costs among patients with seasonal versus perennial allergic rhinitis. ( 27657517 )
2016
41
Local allergic rhinitis: entopy or spontaneous response? ( 27980704 )
2016
42
MODIFIER FACTORS OF ALLERGIC RHINITIS AND EOSINOPHILIC RHINOSINUSITS: CLINICAL APPLICATION. ( 27193924 )
2016
43
Utility of the Atopy Patch Test in the Diagnosis of Allergic Rhinitis. ( 27429944 )
2016
44
Local allergic rhinitis in children: Novel diagnostic features and potential biomarkers. ( 27657898 )
2016
45
Effects of omalizumab therapy on allergic rhinitis: a pilot study. ( 28051241 )
2016
46
Dust Mite-Induced Perennial Allergic Rhinitis in Pediatric Patients and Sublingual Immunotherapy. ( 27665384 )
2016
47
A proteomics analysis reveals that A2M might be regulated by STAT3 in persistent allergic rhinitis. ( 27228572 )
2016
48
Association between JAK1 gene polymorphisms and susceptibility to allergic rhinitis. ( 27007833 )
2016
49
Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children. ( 27255477 )
2016
50
Alternative Method for Primary Nasal Epithelial Cell Culture Using Intranasal Brushing and Feasibility for the Study of Epithelial Functions in Allergic Rhinitis. ( 26540504 )
2016

Variations for Allergic Rhinitis

Expression for Allergic Rhinitis

LifeMap Discovery
Genes differentially expressed in tissues of Allergic Rhinitis patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CST1 cystatin SN Respiratory System + 6.00 0.000
Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for Allergic Rhinitis

Pathways related to Allergic Rhinitis according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 ALOX5 CCL11 CXCL8 EPX ICAM1 IGHE
2
Show member pathways
13.47 CCL11 CXCL8 ICAM1 IL13 IL4 IL4R
3
Show member pathways
13.34 CCL11 CXCL8 IL13 IL4 IL4R IL5
4
Show member pathways
13.26 ALOX5 CCL11 CXCL8 ICAM1 IGHE IL13
5
Show member pathways
13.23 CCL11 CXCL8 IL13 IL4 IL4R IL5
6
Show member pathways
12.47 ALOX5 IGHE IL13 IL4 IL5 MS4A2
7
Show member pathways
12.35 CCL11 CXCL8 EPX ICAM1 IL13 IL4
8
Show member pathways
12.32 CCL11 HRH1 IGHE IL4 IL4R
9
Show member pathways
12.24 ALOX5 ICAM1 IL4 MPO
10
Show member pathways
12.24 CCL11 CXCL8 IL13 IL4 IL5
11
Show member pathways
12.14 IL13 IL4 IL4R IL5
12
Show member pathways
12.09 CXCL8 IL13 IL4 IL5
13 11.8 IL4 IL4R IL5
14 11.72 CXCL8 ICAM1 IL13 IL4 IL5
15 11.71 IL13 IL4 IL5
16
Show member pathways
11.68 CXCL8 IL4 IL5
17 11.63 ICAM1 IL4 IL5
18 11.57 CCL11 IGHE IL4 IL4R IL5
19 11.52 CCL11 CXCL8 IL13 IL4 IL5
20 11.45 ICAM1 KNG1 MPO
21 11.42 CXCL8 ICAM1 IL13 IL4
22 11.28 ALOX5 CCL11 CXCL8 ICAM1 IGHE IL13
23 11.27 IL4 IL4R IL5
24 11.25 IL13 IL4 IL5
25 11.23 CCL11 IL13 IL4 IL4R IL5
26 11.21 IL13 IL4 IL5
27 11.12 IL13 IL4 IL5
28 11.11 CCL11 CXCL8 IL13 IL4 IL5
29 10.85 ICAM1 MPO
30 10.73 IL13 IL4 IL4R IL5

GO Terms for Allergic Rhinitis

Cellular components related to Allergic Rhinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALOX5 CCL11 CXCL8 EPX IGHE IL13
2 external side of plasma membrane GO:0009897 9.55 ICAM1 IGHE IL13 IL4 MS4A2
3 extracellular space GO:0005615 9.4 ALOX5 CCL11 CXCL8 EPX ICAM1 IL13

Biological processes related to Allergic Rhinitis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 ICAM1 IL4 IL5
2 cellular response to interleukin-1 GO:0071347 9.65 CCL11 CXCL8 ICAM1
3 positive regulation of B cell proliferation GO:0030890 9.58 IL13 IL4 IL5
4 immune response GO:0006955 9.56 CCL11 CXCL8 IGHE IL13 IL4 IL4R
5 microglial cell activation GO:0001774 9.52 IL13 IL4
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 ICAM1 IL13 IL4
7 positive regulation of macrophage activation GO:0043032 9.49 IL13 IL4R
8 eosinophil chemotaxis GO:0048245 9.46 CCL11 HRH1
9 regulation of proton transport GO:0010155 9.43 IL13 IL4
10 positive regulation of mast cell degranulation GO:0043306 9.43 IL13 IL4 IL4R
11 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
12 positive regulation of immunoglobulin production GO:0002639 9.33 IL13 IL4 IL4R
13 inflammatory response GO:0006954 9.23 ALOX5 CCL11 CXCL8 HRH1 IL13 IL5

Molecular functions related to Allergic Rhinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CXCL8 IL13 IL4 IL5

Sources for Allergic Rhinitis

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
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33 ICD10
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65 SNOMED-CT via Orphanet
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70 UMLS via Orphanet
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