Allergic Rhinitis malady

MedlinePlus: Each spring, summer, and fall, trees, weeds and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat dark circles under the eyes taking medicines, using nasal sprays and rinsing out your nose can relieve symptoms. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases²³

MalaCards: Allergic Rhinitis, also known as hay fever, is related to asthma and rhinitis. An important gene associated with Allergic Rhinitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Akt Signaling and IL-6 Pathway. The drugs beclomethasone and brompheniramine and the compounds calcium and tarc have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and small intestine, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology: A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.⁶

Wikipedia: Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as...⁴⁴ more...

OMIM: 607154

Aliases & Descriptions:

allergic rhinitis 6 8 33 32 hay fever 6 23 43 allergic rhinitis due to animal (cat) (dog) hair and dander 6 allergic rhinitis due to pollen (disorder) 6 seasonal allergic rhinitis (disorder) 6 allergic rhinitis due to pollen 6 non-seasonal allergic rhinitis 6 allergic rhinitis due to food 6 rhinitis, allergic, perennial 43 allergic rhinitis (disorder) 43

allergy to pollen (disorder) 6 perenial allergic rhinitis 6 seasonal allergic rhinitis 6 rhinitis allergic seasonal 32 hay fever - pollens 6 hypersensitivity 43 atopic rhinitis 6 pollenosis 6 pollinosis 6 rhinitis 43

Diseases related to allergic rhinitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 969)

id	Related Disease	Score	Top Affiliating Genes
1	asthma	38.9	SCGB1A1, SCGB3A2, IL12B, IL13, CCL11, HNMT
2	rhinitis	36.2	PIP, PIK3CG, PDCL, PDE4A, RELA, RENBP
3	atopic dermatitis	34.9	PDE4A, KITLG, SELE, VIP, VCAM1, BDNF
4	chronic rhinitis	33.9	MPO, CALCA, HRH1, RNASE3, EDN1, EPX
5	eosinophilia	33.7	PDE4A, SFTPA1, SFTPA2, SFTPD, VCAM1, CLC
6	allergic asthma	33.3	SERPINE1, VCAM1, BDNF, BCL2, SCGB1A1, MS4A2
7	eczema	33.0	BTK, SELE, VIP, MS4A2, MPO, CD79A
8	vernal keratoconjunctivitis	31.8	VCAM1, MMP9, IL13, IL3, IL4, IL5
9	extrinsic allergic alveolitis	31.6	SFTPD, CD14, FCER2, IL18, IL1A, IL8
10	allergic conjunctivitis	31.5	IL13, IL4, IL5, CCL11, IGHE, HRH1
11	allergic bronchopulmonary aspergillosis	31.5	SFTPD, IL4, IL5, MBL2, IGES, IGHE
12	bronchial asthma	31.4	KITLG, SFTPD, SELE, VIP, VEGFA, VCAM1
13	vasomotor rhinitis	31.3	VIP, IL10, IL13, IL16, CALCA, TAC1
14	churg-strauss syndrome	31.2	CHIA, MPO, IL10, IL13, IL2RA, IL4
15	urticaria	30.8	KITLG, SELE, VEGFA, VCAM1, MS4A2, CD79A
16	food allergy	30.4	FOXP3, IL13, IL4, IL5, CCL11, IGES
17	t cell deficiency	30.4	BTK, VCAM1, BCL2, CD79A, CD4, FCGR2A
18	atopy	30.3	RELA, KITLG, VEGFA, KDR, SCGB1A1, MS4A2
19	hypersensitivity reaction type iv disease	30.0	SELE, IL4, IGHE, IFNG, ICAM1, TF
20	polycythemia vera	29.9	PIK3CG, KITLG, SERPINE1, MPO, CD79A, IL3
21	keratoconjunctivitis	29.9	RELA, VIPR1, VEGFA, VCAM1, MUC5AC, CD79A
22	otitis media	29.8	SFTPA1, SFTPA2, SERPINE1, VCAM1, MUC1, MUC2
23	was-related disorders	29.7	BDNF, LEP, CHKB, MPO, IL2RA, IL6
24	fibromyalgia	29.7	SERPINE1, BGLAP, BDNF, CHKB, IL10, IL1B
25	aspergillosis	29.7	SFTPA1, SFTPA2, SFTPD, CD79A, CD4, IL10
26	intrinsic asthma	29.6	FCER2, IL3, IL4, IL5, CCL7, CCL5
27	hypersensitivity reaction type ii disease	29.5	PDE4A, VIP, VCAM1, CD28, CD79A, CD86
28	common cold	29.2	CHIA, IL1R1, IL5, IL8, CCL11, ICAM1
29	rheumatoid arthritis	29.0	CD40, IL10, IL1B, IL1RN, IL23A, HLA-DQA1
30	polycythemia	29.0	PIK3CG, KITLG, SERPINE1, VEGFA, MPO, CD79A
31	immunodeficiency	28.9	BTK, VIP, CD28, CD79A, CD4, CD40LG
32	essential thrombocythemia	28.8	SELE, SERPINE1, BGLAP, MPO, IL3, TNF
33	arthritis	28.6	VIP, IL17A, IL1A, IL1B, IL6, IL8
34	arthus reaction	28.6	FCGR1A, ALOX5, HRH1, HMOX1, TNF, ELANE
35	pulmonary function	28.5	LEP, CHIA, MPO, CD14, IL10, IL13
36	angioedema	28.5	BDKRB2, MS4A2, MME, IL5, IL6, IGHE
37	cutaneous t cell lymphoma	28.4	SELE, ITGAL, IL15, IL2RA, IL4, IL5
38	tuberculosis	28.4	IL10, IL12B, IL1B, IL1RN, IL4, MBL2
39	bullous pemphigoid	28.3	CD79A, ITGAL, FLG, FCER2, IL13, IL5
40	irritable bowel syndrome	28.3	VIP, LEP, MPO, CD79A, CD40LG, IL10
41	cough variant asthma	28.3	IL10, IL4, IL5, IGHE, RNASE3, ACE
42	chronic fatigue syndrome	28.2	VIP, CD4, IL10, IL1R1, IL4, IL6
43	graves' disease	28.1	RETN, KITLG, SELE, VCAM1, BGLAP, BCL2
44	mastocytosis	27.9	KITLG, BGLAP, BCL2, MPO, FCER2, IL13
45	omenn syndrome	27.8	IL10, IL1RN, IL4, IL5, IGHE, IFNG
46	breast cancer	27.5	VEGFA, KDR, BCL2, MMP9, GSTP1, IL10
47	blindness	27.2	PIK3CG, PDE4A, SELE, SERPINF1, SERPINE1, VIP
48	systemic lupus erythematosus	27.1	SELE, VIP, VCAM1, BDNF, MPO, CD28
49	sinusitis	26.9	RELA, SFTPD, BTK, SERPINE1, VEGFA, VCAM1
50	erythema multiforme	26.9	CD79A, CCL22, CCL17, CCL1, CCR3, CCL5

Clinical features from OMIM: 607154

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acrivastine, astemizole, azatadine, azatadine maleate, azelastine, azelastine hydrochloride, beclomethasone, beclomethasone dipropionate, bromodiphenhydramine, bromodiphenhydramine hydrochloride, brompheniramine, brompheniramine maleate, budesonide, carbinoxamine, carbinoxamine maleate, cetirizine, cetirizine hydrochloride, chlorcyclizine, chlorcyclizine hydrochloride, chlorothen maleate, chlorpheniramine, chlorpheniramine maleate, chlorpheniramine polistirex, chlorpheniramine tannate, clemastine, clemastine fumarate, cromolyn, cromolyn sodium, cyproheptadine, cyproheptadine hydrochloride, cyproheptadine hydrochloride monohydrate, desloratadine, dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], dexbrompheniramine, dexbrompheniramine maleate, dexchlorpheniramine, dexchlorpheniramine maleate, diphenhydramine, diphenhydramine citrate, diphenhydramine hydrochloride, doxylamine, doxylamine succinate, ephedra, ephedrine, ephedrine hydrochloride, ephedrine sulfate, ephedrine tannate, fexofenadine, fexofenadine hydrochloride, flunisolide, fluticasone, fluticasone furoate, fluticasone propionate, guaifenesin, hyoscyamine, hyoscyamine hydrobromide, hyoscyamine sulfate, ipratropium, ipratropium bromide, loratadine, methapyrilene, methapyrilene hydrochloride, methdilazine, methdilazine hydrochloride, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, mometasone, mometasone furoate, mometasone furoate monohydrate, montelukast, montelukast sodium, naphazoline, naphazoline hydrochloride, oxymetazoline, oxymetazoline hydrochloride, phenindamine, phenindamine tartrate, phenylpropanolamine, phenylpropanolamine hydrochloride, phenyltoloxamine, phenyltoloxamine citrate, phenyltoloxamine dihydrogen citrate, phenyltoloxamine resin complex, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], promethazine, promethazine hydrobromide, promethazine hydrochloride, pseudoephedrine, pseudoephedrine hydrochloride, pseudoephedrine sulfate, pyrilamine, pyrilamine maleate, pyrilamine tannate, triamcinolone, triamcinolone acetonide, triamcinolone acetonide pwdr [va product], triamcinolone diacetate, triamcinolone hexacetonide, trimeprazine, trimeprazine tartrate, tripelennamine, tripelennamine citrate, tripelennamine hydrochloride

MalaCards organs/tissues related to allergic rhinitis:

²²

MGI Mouse Phenotypes related to allergic rhinitis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	12.0	BTK, BDKRB2, BCL2, CD28, CD3D, CD86
2	respiratory system phenotype	MP:0005388	11.4	SFTPD, BDNF, SCGB1A1, LGR5, CD14, FOXJ1
3	endocrine/exocrine gland phenotype	MP:0005379	10.6	VIPR1, BDKRB2, LGR5, CD40LG, AQP5, IFNG
4	renal/urinary system phenotype	MP:0005367	9.8	PDC, RENBP, CLCN3, BDKRB2, BCL2, SCGB1A1
5	normal phenotype	MP:0002873	9.7	RELA, SELE, VIP, VEGFA, BDKRB2, BDNF
6	integument phenotype	MP:0010771	9.6	PIK3CG, RELA, KITLG, BTK, BDNF, BCL2
7	liver/biliary system phenotype	MP:0005370	9.4	RETN, VEGFA, CLCN3, IL12RB2, IL1R1, IL6
8	immune system phenotype	MP:0005387	9.3	PDE4A, BTK, VIPR2, BPIFA1, CLCN3, BDKRB2
9	behavior/neurological phenotype	MP:0005386	9.0	SELE, VIP, VIPR1, VIPR2, CLCN3, BDKRB2
10	nervous system phenotype	MP:0003631	8.8	PDC, PDE4A, RELA, KITLG, SERPINF1, CLCN3
11	no phenotypic analysis	MP:0003012	8.7	VEGFA, VCAM1, BDNF, LGR5, MUC1, T
12	digestive/alimentary phenotype	MP:0005381	8.1	KITLG, BTK, SERPINF1, VIPR1, VEGFA, CLCN3
13	reproductive system phenotype	MP:0005389	7.9	SERPINF1, VIP, VIPR2, VEGFA, CLCN3, BDKRB2
14	mortality/aging	MP:0010768	7.9	RELA, KITLG, SFTPD, BTK, SELE, SERPINE1
15	growth/size phenotype	MP:0005378	7.8	PIK3CG, RELA, KITLG, SFTPD, BTK, SELE
16	adipose tissue phenotype	MP:0005375	7.4	RETN, SERPINE1, VIPR2, CLCN3, BDKRB2, BCL2
17	skeleton phenotype	MP:0005390	6.7	PIK3CG, RELA, KITLG, VEGFA, CLCN3, BDKRB2
18	vision/eye phenotype	MP:0005391	5.9	PDC, RELA, KITLG, SELE, SERPINF1, VEGFA
19	tumorigenesis	MP:0002006	5.5	KITLG, BTK, SERPINE1, BCL2, SCGB1A1, LGR5
20	cellular phenotype	MP:0005384	5.4	PIK3CG, RELA, KITLG, BTK, SELE, VIPR1
21	homeostasis/metabolism phenotype	MP:0005376	5.1	PIK3CG, PDC, RELA, RENBP, RETN, KITLG
22	muscle phenotype	MP:0005369	4.5	PIK3CG, PDC, RELA, VEGFA, KDR, BCL2
23	cardiovascular system phenotype	MP:0005385	4.3	PIK3CG, PDC, PDE4A, RELA, KITLG, SELE

Articles related to allergic rhinitis:

(show top 50)    (show all 511)

id	Title	Authors	Year	Affiliating Genes
1	Modulation of NK cell autocrine-induced eosinophil ch emotaxis by interleukin-15 and vitamin D(3): a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic rhinitis. (21765616)	el-Shazly A.E.... Lefebvre P.P.	2011	IL8, IL15
2	Forkhead box P3+ T cells express interleukin-17 in na sal mucosa of patients with both allergic rhinitis and polyposis. (21091665)	Liu T.... Yang P.C.	2011	FOXP3, IL17A
3	Upregulation of IL17RB during natural allergen exposu re in patients with seasonal allergic rhinitis. (21252617)	Matsumoto Y.... Fujieda S.	2011	IL17RB
4	Identification of polymorphisms in the RNase3 gene an d the association with allergic rhinitis. (19760211)	Kang I.... Lee J.H.	2010	RNASE3
5	A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. (19222422)	Benson M.... Cardell L.O.	2009	ITK, IL4, CD3D
6	The expression of mucins gene in the human nasal pol yps and allergic rhinitis (20128280)	Ji C.... Guo Y.	2009	MUC2, MUC5AC
7	Sublingual immunotherapy affects specific antibody an d TGF-beta serum levels in patients with allergic rhinitis. (20074473)	Ciprandi G.... Marseglia G.L.	2009	IL4, IFNG
8	Re-treatment with omalizumab at one year interval for Japanese cedar pollen-induced seasonal allergic rhinitis is effective and well tolerated. (19218816)	Ogino S.... Ishikawa T.	2009	IGHE
9	A study of costimulatory molecules in allergic allergic rhinitis patients (19086656)	Zhu R.... Zhang W.	2008	CD40LG, CD40, CD86
10	Allergic rhinitis and asthma connection: treatment implications. (19173782)	Greenberger P.A.	2008	IL10
11	The Allergic Rhinitis and its Impact on Asthma system: a new classification of allergic rhinitis and nasal responsiveness. (17498329)	Sheahan P.... Costello R.W.	2008	KNG1
12	Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis (18260253)	Gawlik R.... Jawor B.	2007	EDN1
13	The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma. (17349011)	Lee J.H.... Chiang B.L.	2007	IL10
14	Expression of T-bet in nasopharyngeal associated lym phatic tissue of patients with allergic rhinitis]. (17993020)	Qu S.... Lin Z.	2007	TBX21
15	STAT1 is involved in the pathogenesis of murine allergic rhinitis. (17424888)	Hattori H.... Satoskar A.R.	2007	STAT1
16	Effects of pollen and nasal glucocorticoid on FOXP3+, GATA-3+ and T-bet+ cells in allergic rhinitis. (17686103)	Malmhall C.... Lotvall J.	2007	T
17	The expression of serum IL-10,12,13,16 in patients with allergic rhinitis and vasomotor rhinitis (18254318)	Chen J.... Tan H.	2007	IL10, IL13, IL16
18	Effects of electroacupuncture on plasma vasoactive intestinal peptide and substance P in perennial allergic rhinitis patients (17650661)	Li Y.M.... Jiang G.H.	2007	VIP
19	Correlation of immunoglobulin E, eosinophil cationic protein, and eosinophil count with the severity of childhood perennial allergic rhinitis. (16783451)	Chen S.T.... Chou M.C.	2006	RNASE3
20	Hyperresponsiveness of congestive nasal reflexes in allergic rhinitis. (16550954)	Sheahan P.... Costello R.W.	2006	KNG1
21	Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. (17181111)	Chung Y.S.... Kim S.T.	2006	GSTP1
22	Omalizumab is effective and safe in the treatment of Japanese cedar pollen-induced seasonal allergic rhinitis. (17130680)	Okubo K.... Ishikawa T.	2006	IGHE
23	Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis. (17165277)	Ciebiada M.... GA^rski P.	2006	RNASE3
24	Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis. (16518568)	Li C.-S.... Chung H.-T.	2006	FOXJ1
25	Seasonal non-allergic rhinitis (SNAR)--a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis. (16008061)	WedbAock A.... Malcus I.	2005	IGHE
26	Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. (15857205)	Mao T.K.... Gershwin M.E.	2005	IL4, IFNG
27	Upregulation of oncostatin m in allergic rhinitis. (16369169)	Kang H.J.... Lee H.M.	2005	OSM
28	Association between HLA class II locus and the susceptibility to Artemisia pollen-induced allergic rhinitis in Chinese population. (14990915)	Wang M.... Yu L.S.	2004	HLA-DQA1, HLA-DQB1
29	Effects of single or combined histamine H1-receptor a nd leukotriene CysLT1-receptor antagonism on nasal adenosine monophosphate chal lenge in persistent allergic rhinitis. (15151516)	Lee D.K.... Lipworth B.J.	2004	HRH1
30	The effect of budesonide on the cytokine pattern in p atients with perennial allergic rhinitis. (14692430)	Ciprandi G.... Vizzaccaro A.	2003	IL4, IL5
31	Eosinophil count in nasal mucosa is more suitable than the number of ICAM-1-positive nasal epithelial cells to evaluate the severity of house dust mite-sensitive allergic rhinitis: a clinical correlation study. (14555860)	Klaewsongkram J.... Phanupak P.	2003	ICAM1
32	Preformed enzymes in mast cell granules and their potential role in allergic rhinitis. (12662477)	Parikh S.A.... Oh C.K.	2003	KNG1
33	Expression of chloride channel in nasal mucosa with allergic rhinitis (12889100)	Li H.B.... Yang L.	2003	CLCN3
34	Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population. (12018331)	Takeuchi K.... Sakakura Y.	2002	TAP1, TAP2
35	Expression of nitric oxide synthases and in vitro migration of eosinophils from allergic rhinitis subjects. (12020693)	Ferreira H.H.... de Nucci G.	2002	CCL11
36	Mizolastine provides effective symptom relief in patients suffering from perennial allergic rhinitis: a double-blind, placebo-controlled study versus loratadine. (12269652)	FrA"che C.... Soussen P.B.	2002	HRH1
37	Retrospective study on fluticasone propionate aqueous nasal spray efficacy in patients with allergic rhinitis: evaluation of clinical and laboratory parameters. (11167349)	Ventura M.T.... Tursi A.	2001	RNASE3
38	In vivo expression of signal transducer and activator of transcription factor 6 (STAT6) in nasal mucosa from atopic allergic rhinitis: effect of topical corticosteroids. (10606935)	Ghaffar O.... Hamid Q.	2000	STAT6, IL4
39	Determination of the immune function of the erythrocyte and leucocyte and the activity of IL-4 and IFN-gamma in patients with allergic rhinitis (12768759)	Zhou B.... Chen X.	2000	IL4, IFNG
40	Circadian variation in nasal reactivity in children with allergic rhinitis: correlation with the activity of eosinophils and basophilic cells. (10529614)	Aoyagi M.... Kohno Y.	1999	RNASE3
41	Regulation of proinflammatory cytokines in seasonal allergic rhinitis. (10224452)	Bachert C.... Van Cauwenberge P.	1999	IL1B, IL8, RNASE3
42	Th-2 type cytokine receptors in allergic rhinitis and in response to topical steroids. (9778295)	Wright E.D.... Hamid Q.	1998	IL4, IL5RA, IL5
43	Serum eosinophil cationic protein (ECP) levels in patients with seasonal allergic rhinitis and allergic asthma. (9578914)	Sin A.... KabakAsi T.	1998	RNASE3, IGHE
44	The pharmacological basis for the treatment of perenn ial allergic rhinitis and non-allergic rhinitis with topical corticosteroids. (9212861)	Meltzer E.O.	1997	IL6, NR3C1, IFNG
45	Cytokines in nasal fluids from school children with seasonal allergic rhinitis. (9532255)	Benson M.... StrannegAYrd O.	1997	IL4, IL10, IL5
46	Determination of the diagnostic efficacy of the mult i-RAST test (Phadiotop) in allergic rhinitis (7734158)	BujA-a J.... Rasp G.	1995	IGHE
47	Nd:YAG laser surgery in treatment of allergic rhinitis (7545400)	Jovanovic S.... Dokic D.	1995	KNG1
48	Inflammation mediators (eosinophilic cationic protein, ECP) in a normal population and in patients with bronchial asthma or allergic rhinitis (7627423)	Alvarez GutiAcrrez F.J.... Castillo GA^mez J.	1995	RNASE3
49	Do nasal mast cells release histamine on stimulation with substance P in allergic rhinitis? (7531109)	Braunstein G.... Frossard N.	1994	ALB
50	Acrivastine. A review of its pharmacological properti es and therapeutic efficacy in allergic rhinitis, urticaria and related disorde rs. (1715267)	Brogden R.N.... McTavish D.	1991	HRH1

Genes related to allergic rhinitis according to GeneCards:

(show top 50)    (show all 253)

id	Symbol	Description	Score	GeneCards Section Context
1	CCL11	chemokine (C-C motif) ligand 11	11.1	Publications, Summaries
2	NGF	nerve growth factor (beta polypeptide)	11.1	Summaries, Publications
3	IL13	interleukin 13	11.1	Aliases & Descriptions, Publications
4	IL4R	interleukin 4 receptor	11.1	Summaries, Publications
5	FOXJ1	forkhead box J1	11.1	Publications, Summaries
6	ALRH	allergic rhinitis	11.1	Aliases & Descriptions, Publications
7	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
8	IGES	immunoglobulin E concentration, serum	11.0	Publications
9	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
10	CLC	Charcot-Leyden crystal protein	11.0	Publications
11	HRH1	histamine receptor H1	11.0	Publications
12	EPX	eosinophil peroxidase	11.0	Publications, UniProt Related
13	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
14	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
15	CCL24	chemokine (C-C motif) ligand 24	11.0	Publications
16	IL9	interleukin 9	11.0	Publications
17	CCL13	chemokine (C-C motif) ligand 13	11.0	Publications
18	SCG2	secretogranin II	11.0	Publications
19	GATA3	GATA binding protein 3	11.0	Publications
20	HAVCR1	hepatitis A virus cellular receptor 1	11.0	Publications
21	IL4	interleukin 4	11.0	Publications
22	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
23	CCL7	chemokine (C-C motif) ligand 7	11.0	Publications
24	FCER1A	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	11.0	Publications
25	TPT1	tumor protein, translationally-controlled 1	11.0	Publications
26	CCR8	chemokine (C-C motif) receptor 8	11.0	Publications
27	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
28	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
29	HNMT	histamine N-methyltransferase	11.0	Publications
30	HAVCR2	hepatitis A virus cellular receptor 2	11.0
31	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0
32	CCR3	chemokine (C-C motif) receptor 3	11.0	Publications
33	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
34	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
35	TBXA2R	thromboxane A2 receptor	11.0	Publications
36	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
37	IL17A	interleukin 17A	11.0	Publications
38	VIP	vasoactive intestinal peptide	11.0	Publications
39	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
40	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0
41	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
42	TAC1	tachykinin, precursor 1	11.0	Publications
43	IL13RA2	interleukin 13 receptor, alpha 2	11.0
44	TRPV1	transient receptor potential cation channel, subfamily V, member 1	11.0	Publications
45	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
46	ICAM1	intercellular adhesion molecule 1	11.0	Publications
47	KNG1	kininogen 1	11.0	Publications
48	IL16	interleukin 16	11.0	Publications
49	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
50	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications

Pathways related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 196)

id	Pathway	Score	Top Affiliating Genes
1	Akt Signaling36	11.5	PIP, PIK3CG, BTK, CD28, CD4, ITGAL
2	IL-6 Pathway36	11.4	PIP, BTK, IL10, IL12A, IL12B, IL16
3	Chemokine signaling pathway20	11.2	PIK3CG, RELA, ITK, IL8, MAPK1, CCL8
4	Immune System38	11.1	VCAM1, CD79A, CD40, FCGR1A, FCGR3A, IL18
5	Jak-STAT signaling pathway20	11.0	PIK3CG, LEP, IL10, IL12A, IL12B, IL12RB1
6	Cytokine production by Th17 cells in CF (Mouse model)41	10.7	RELA, CD14, FOXP3, IL12B, IL12RB1, IL17A
7	all-trans-Retinoic Acid Signaling in Brain36	10.7	PIP, BTK, BCL2, IL10, IL12A, IL12B
8	Regulation of eIF4 and p70S6K36	10.7	BTK, CD4, ITGAL, IL12A, IL12B, IL13
9	Bacterial infections in CF airways41	10.7	RELA, SFTPA1, SFTPD, MUC1, IRAK4, IL1R1
10	Asthma20	10.6	MS4A2, CD40LG, CD40, FCER1A, IL10, IL13
11	SOCS Pathway36	10.6	BTK, BCL2, CD4, IL10, IL12A, IL12B
12	PGC1Alpha Pathway36	10.4	BTK, BCL2, CD4, IL12A, IL12B, IL13
13	Phagosome20	10.3	SFTPA1, SFTPD, MPO, CD14, FCGR1A, FCGR2A
14	THC Differentiation Pathway36	10.3	CD28, CD86, IL10, IL12A, IL12B, IL12RB1
15	Malaria20	10.3	SELE, VCAM1, CD40LG, CD40, ITGAL, IL10
16	Cytokine Network36	10.2	IL10, IL12A, IL12B, IL13, IL15, IL16
17	MIF Mediated Glucocorticoid Regulation36	10.2	PIP, BTK, BCL2, CD14, IL10, IL12A
18	Cytokine-cytokine receptor interaction20	10.1	KITLG, VEGFA, KDR, LEP, CD40LG, CD40
19	African trypanosomiasis20	10.0	SELE, VCAM1, IL10, IL12A, IL12B, IL18
20	JNK Pathway36	9.9	KITLG, BTK, KDR, BCL2, JUN, CD4
21	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	IL12B, IL17A, IL1B, IL23A, IL4, IL4R
22	Amoebiasis20	9.8	RELA, MUC2, CD14, IL12A, IL12B, IL1B
23	Autoimmune thyroid disease20	9.7	CD28, CD86, CD40LG, CD40, IL10, IL4
24	MIF Regulation of Innate Immune Cells36	9.6	PIP, BTK, BCL2, JUN, CD14, IL10
25	Allograft rejection20	9.3	CD28, CD86, CD40LG, CD40, IL10, IL12A
26	Glucocorticoid Receptor Signaling36	9.3	BTK, BCL2, JUN, CD4, IL10, IL12A
27	Immune response MIF-mediated glucocorticoid regulation10	9.2	RELA, VCAM1, JUN, IL6, IL8, MAPK1
28	ERK Signaling36	9.2	PIP, KITLG, BTK, CD3D, ITGAL, IL10
29	Endothelin-1 Signaling Pathway36	9.2	PIP, BTK, IL10, IL12A, IL12B, IL13
30	Rheumatoid arthritis20	9.0	VEGFA, JUN, CD28, CD86, ITGAL, IL15
31	p38 Signaling36	9.0	PIP, KITLG, BTK, BDNF, KDR, BCL2
32	T cell receptor signaling pathway20	9.0	PIK3CG, RELA, JUN, CD28, CD3D, CD4
33	Type I diabetes mellitus20	9.0	CD28, CD86, IL12A, IL12B, IL1A, IL1B
34	Immune response MIF in innate immunity response10	8.7	RELA, JUN, CD14, IRAK4, IL1B, IL6
35	Immune response_MIF in innate immunity response41	8.7	RELA, JUN, CD14, IRAK4, IL1B, IL6
36	NF-KappaB (p50-p65) Pathway36	8.7	RELA, KITLG, BDNF, KDR, IRAK4, IL1A
37	Toll-like receptor signaling pathway20	8.7	PIK3CG, RELA, JUN, CD86, CD14, CD40
38	Molecular Mechanisms of Cancer36	8.6	PIP, PIK3CG, KITLG, BTK, BDNF, KDR
39	Antioxidant Action of Vitamin-C36	8.6	PIP, KITLG, BTK, BDNF, KDR, BCL2
40	Chagas disease (American trypanosomiasis)20	8.3	PIK3CG, RELA, SERPINE1, BDKRB2, JUN, CD3D
41	Toxoplasmosis20	8.3	PIK3CG, RELA, BCL2, CD40LG, CD40, IRAK4
42	Tuberculosis20	8.3	RELA, BCL2, CD14, IRAK4, FCGR1A, FCGR2A
43	Osteoclast differentiation20	8.3	PIK3CG, RELA, BTK, JUN, FCGR1A, FCGR2A
44	Immune response IL-22 signaling pathway10	8.3	BCL2, JUN, CD28, CD86, CD4, IL12A
45	Immune response_IL-22 signaling pathway41	8.2	BCL2, JUN, CD28, CD86, CD4, IL12A
46	NF-KappaB Family Pathway36	8.2	RELA, KITLG, BDNF, KDR, IRAK4, IL1A
47	Immune response IL-1 signaling pathway10	7.8	RELA, SERPINE1, JUN, IRAK4, IL1A, IL1B
48	Immune response_IL-1 signaling pathway41	7.8	RELA, SERPINE1, JUN, IRAK4, IL1A, IL1B
49	NFAT in Immune Response36	7.5	KITLG, BTK, BDNF, KDR, JUN, CD28
50	MAPK Signaling36	6.6	KITLG, BDNF, KDR, BCL2, JUN, ITGAL

Compounds related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 479)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	14.9	PDC, PDE4A, RELA, RETN, KITLG, SFTPA1
2	tarc32	11.4	CD4, IL10, IL13, IL18, IL1A, IL4
3	histamine32 18	12.1	PDE4A, KITLG, SFTPD, BTK, SELE, VIP
4	glucose32	11.1	PDE4A, SERPINF1, VIPR1, SCG2, MME, IL18R1
5	atp32	11.0	PDE4A, RENBP, BTK, CLCA1, BDKRB2, BDNF
6	capsaicin32	11.0	SELE, VIP, BDNF, SCG2, LEP, MME
7	cyclic amp32 18	11.9	PDC, PDE4A, SFTPD, BDKRB2, BDNF, SCG2
8	sp 60012532 42	11.7	PIK3CG, VCAM1, CD40, IL13, IL17A, AKT1
9	ivig32	10.6	BTK, FCGR1A, FCGR3A, IL18R1, IL1RAPL2, IL3
10	ifn-alpha32	10.6	IL10, IL13, IL17A, IL18, IL2RA, IL6
11	pge132	10.6	PDC, PDE4A, SERPINE1, VIP, CD40, IL18
12	p00332	10.5	RETN, SERPINE1, LEP, CD14, FOXP3, IL13
13	poly(i-c)32	10.5	VCAM1, IL12B, IL15, IL18, IL1B, IL3
14	okt332	10.2	SELE, VCAM1, CD79A, CD40LG, FCER2, IL10
15	polymyxin b32	10.2	SELE, SERPINE1, VCAM1, CD14, IL10, IL1A
16	tacrolimus32 34 9 9	13.1	SERPINE1, CHKB, CD28, CD79A, CD86, CD40
17	leukotriene b432 42 18	11.9	PDE4A, MPO, ITGAL, MMP9, FCER2, IL13
18	il 1032	9.8	CD40, IL10, IL12B, IL13, IL15, IL18
19	forskolin32 42 9 9	12.7	PDE4A, RETN, VIP, VIPR1, BDKRB2, BDNF
20	imiquimod32 42 9 9	12.7	IL10, IL12B, IL18, IL1A, IL1RAPL2, IL5
21	n(g)-nitro-l-arginine methyl ester32	9.6	SERPINE1, VIP, BDKRB2, BDNF, LEP, CALCA
22	salicylic acid32	9.6	PIK3CG, CD40, FLG, IL13, IL1RAPL2, IL1RN
23	thalidomide32 42 9 9	12.5	PDE4A, VEGFA, KDR, CD40LG, IL10, IL18
24	etanercept32 9 9	11.5	LEP, FCGR1A, FCGR2A, FCGR3A, IL10, IL15
25	corticosterone32 18	10.5	VIP, BGLAP, BDNF, MPO, IL1A, IL1B
26	pertussis32	9.4	PIK3CG, VIP, JUN, ITGAL, MAPK1, CCL22
27	cholesterol32 9 18 9	12.3	RETN, KITLG, SFTPD, SELE, SERPINE1, VCAM1
28	calcitriol32 42 9 18 9	13.3	KITLG, BGLAP, JUN, CD14, ITGAL, FLG
29	aspirin32 34 18	11.2	PDE4A, KITLG, SELE, SERPINE1, CHKB, CD79A
30	neopterin32	9.0	CHIT1, CHKB, CD79A, CD14, CD4, CD40LG
31	nmda32 42	9.9	PDE4A, BDNF, LEP, IL18R1, IL1A, IL1R1
32	tgf beta132	8.9	KITLG, SERPINE1, VCAM1, KDR, MMP9, FOXP3
33	arginine32	8.8	PDC, PDE4A, BTK, VIP, BGLAP, BDKRB2
34	ns 39832 42	9.7	PIK3CG, BGLAP, IL17A, IL1A, IL1B, IL8
35	sb 20358032 42	9.6	BTK, SELE, VEGFA, VCAM1, BGLAP, BCL2
36	oxygen32 18	9.5	KITLG, SFTPD, SERPINF1, BDNF, BCL2, SCGB1A1
37	prostaglandin32	8.5	PDE4A, KITLG, VIP, BDKRB2, MUC5AC, CD40
38	nitric oxide32 9 18 9	11.4	PDE4A, RETN, KITLG, SFTPD, SELE, SERPINF1
39	cyclosporin a32 42	9.1	PIK3CG, PDE4A, KITLG, VIP, BGLAP, LEP
40	matrigel32	8.1	PIK3CG, SELE, SERPINF1, SERPINE1, VEGFA, VCAM1
41	prostacyclin32	8.0	PDE4A, SELE, SERPINE1, VIP, VEGFA, VCAM1
42	cysteine32	7.9	RENBP, SFTPD, BTK, SERPINF1, BGLAP, PAPPA
43	phorbol32	7.8	JUN, CD4, CD40, ITGAL, MMP9, IL1R1
44	doxorubicin32 34 9 9	10.7	PIK3CG, KITLG, SELE, BDNF, KDR, CD40LG
45	adenylate32	7.1	PIK3CG, PDC, PDE4A, KITLG, SELE, SERPINE1
46	indomethacin32 9 9	8.8	PDE4A, VIP, BDKRB2, BDNF, KDR, LEP
47	celecoxib32 42 34 9 18 9	11.4	PIK3CG, VEGFA, KDR, BCL2, MMP9, IL1B
48	ag 147832	6.4	PIK3CG, SERPINE1, MUC5AC, JUN, MMP9, IL8
49	cisplatin32 34 9 9	9.2	KITLG, VEGFA, BGLAP, BDNF, KDR, BCL2
50	curcumin32	5.2	PIK3CG, VEGFA, VCAM1, BCL2, JUN, MMP9

Cellular components related to allergic rhinitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	10.5	VIPR1, VIPR2, CLCA1, TGFBR3, TACR1, CXCR2
2	external side of plasma membrane	GO:009897	10.0	CD28, CD79A, CD86, CD4, CD40LG, CD40
3	platelet alpha granule lumen	GO:031093	9.9	TGFB1, TIMP1, PF4, PPBP, ALB, VEGFA
4	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.6	HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
5	cell surface	GO:009986	9.4	NOD2, NGFR, ELANE, TLR2, TLR3, TGFB1
6	ER to Golgi transport vesicle membrane	GO:012507	9.4	HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
7	extracellular space	GO:005615	8.6	WNT2B, KNG1, ADIPOQ, MBL2, CCL14, CCL5
8	extracellular region	GO:005576	8.5	CCL7, PTGDS, SPP1, NTF3, PPBP, PLA2G7
9	plasma membrane	GO:005886	7.5	HMOX2, PTGDR2, PTGS1, TBXA2R, CYSLTR2, CYSLTR1

Biological processes related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 92)

id	Name	GO ID	Score	Top Affiliating Genes
1	eosinophil chemotaxis	GO:048245	11.3	CCL5, CCL13, CCL24, CCR3, CCL11, SCG2
2	immune response	GO:006955	11.2	C5AR1, CSF2, PRG2, OSM, TGFBR3, TLR4
3	chemotaxis	GO:006935	11.2	CCR3, CCL1, CCL17, CCL20, CCR8, CCL11
4	positive regulation of tumor necrosis factor production	GO:032760	11.1	TLR4, TLR3, TLR2, PF4, NOD2, NOD1
5	cell-cell signaling	GO:007267	11.0	CCL22, CD86, CCL24, CCL13, CCL5, CALCA
6	elevation of cytosolic calcium ion concentration	GO:007204	11.0	KNG1, C3AR1, C5AR1, CXCR3, TAC1, TACR1
7	defense response to bacterium	GO:042742	10.9	NOD1, NOD2, NOS2, RNASE3, LTF, TLR3
8	inflammatory response	GO:006954	10.8	SCG2, BDKRB2, SELE, RELA, PIK3CG, CCL17
9	leukocyte cell-cell adhesion	GO:007159	10.7	SELE, SYK, CALCA, ICAM1, CCL5, APOA4
10	positive regulation of interleukin-12 production	GO:032735	10.7	TLR9, TLR4, TLR3, HLA-G, TLR2, IFNG
11	positive regulation of T cell proliferation	GO:042102	10.7	IL4, IFNG, VCAM1, CD28, ITGAL, IL6
12	G-protein coupled receptor signaling pathway	GO:007186	10.6	IL8, CXCR1, CCR8, AGT, EDN1, TBXA2R
13	cellular response to lipopolysaccharide	GO:071222	10.6	TLR4, CD14, SERPINE1, GSTP1, LTC4S, NOS2
14	cellular calcium ion homeostasis	GO:006874	10.5	CCL11, CCL7, CCL14, CCL1, CCL5, TRPM8
15	positive regulation of NF-kappaB import into nucleus	GO:042346	10.3	TNF, IL1B, TLR4, IL12B, TLR2, TLR9
16	positive regulation of inflammatory response	GO:050729	10.3	SERPINE1, IL12B, IL15, IL18, IL23A, IL33
17	positive regulation of interleukin-8 production	GO:032757	10.3	TLR4, TLR9, ADIPOQ, TLR2, TLR3, IL1B
18	positive regulation of interferon-gamma production	GO:032729	10.2	TLR4, TNF, IL23A, IL1B, IL18, IL12RB2
19	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.2	ICAM1, TNF, TNFRSF8, NOD1, NOD2, NLRP3
20	interferon-gamma-mediated signaling pathway	GO:060333	10.2	HLA-G, HLA-DRB4, STAT1, HLA-DRB1, HLA-DQA1, HLA-C
21	defense response to Gram-negative bacterium	GO:050829	10.1	S100A7, SERPINE1, CD4, IL12B, TLR4, NOS2
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.1	IL6, AGT, VEGFA, SYK, OSM, ADIPOQ
23	defense response to virus	GO:051607	10.1	CD40, CD86, RELA, TLR3, NLRP3, F2RL1
24	positive regulation of interleukin-6 production	GO:032755	10.1	IL1A, IL33, IL6, TLR4, TNF, NOD1
25	positive regulation of vasoconstriction	GO:045907	10.0	TACR1, CYSLTR1, TBXA2R, PTGS1, PTGS2, ALOX5
26	lipopolysaccharide-mediated signaling pathway	GO:031663	9.8	IL18, IL1B, TGFB1, TLR4, TLR2, STAT1
27	response to glucocorticoid stimulus	GO:051384	9.8	ADIPOQ, NGF, PTGDS, PTGS2, IL1RN, IL10
28	cytokine-mediated signaling pathway	GO:019221	9.8	VCAM1, HLA-DRB4, HLA-G, PF4, EGR1, STAT1
29	neutrophil chemotaxis	GO:030593	9.8	C5AR1, EDN1, SPP1, PIK3CG, IL1B, PRKCA
30	Toll signaling pathway	GO:008063	9.4	JUN, BTK, CD14, IRAK4, NFKB1, RELA
31	toll-like receptor 4 signaling pathway	GO:034142	9.4	NOD2, NFKB1, RELA, BTK, JUN, CD14
32	positive regulation of cell proliferation	GO:008284	9.3	CSF2, IL15, EDN1, NGF, CCL14, IL9
33	cell surface receptor signaling pathway	GO:007166	9.3	IL12RB2, IL1R1, IL2RA, MAPK14, IFNG, TRPV1
34	signal transduction	GO:007165	9.2	CCL8, PDE4A, KITLG, VIPR2, MAPK1, MAPK14
35	response to ethanol	GO:045471	9.2	TH, IL13, IL4, ICAM1, TLR4, TACR1
36	anti-apoptosis	GO:006916	9.2	AKT1, HMOX1, MPO, RELA, BDNF, BCL2
37	toll-like receptor signaling pathway	GO:002224	9.2	RELA, JUN, CD86, BTK, TLR4, TLR2
38	positive regulation of nitric oxide biosynthetic process	GO:045429	9.2	IL1B, IFNG, HRH1, TNF, PTGS2, EGFR
39	aging	GO:007568	9.0	IL15, JUN, VCAM1, CALCA, CCL5, IL1B
40	positive regulation of angiogenesis	GO:045766	8.9	CCL5, CCL24, CCR3, CCL11, IL1B, IL1A
41	response to drug	GO:042493	8.8	TBXA2R, ABP1, TGFB1, TGFBR2, SOD1, GATA3
42	positive regulation of smooth muscle cell proliferation	GO:048661	8.8	STAT1, IL13, TNF, JUN, IRAK4, PTGS2
43	response to heat	GO:009408	8.8	MMP9, IL1B, CALCA, AKT1, NOS1, TACR1
44	response to lipopolysaccharide	GO:032496	8.8	EDN1, JUN, MMP9, IL12A, IL13, IL1A
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.7	NTF3, RELA, IL33, IL4, IL6, MAPK14
46	innate immune response	GO:045087	8.6	SYK, PIK3CG, RELA, SFTPD, BTK, BPIFA1
47	negative regulation of apoptotic process	GO:043066	8.2	CSF2, EGFR, PF4, TNF, AKT1, ALB
48	response to hypoxia	GO:001666	8.1	IL1B, EDN1, NOS2, TGFBR3, VCAM1, TLR4
49	platelet activation	GO:030168	8.1	VEGFA, SERPINE1, CD40, PIK3CG, TF, SYK
50	blood coagulation	GO:007596	7.6	SOD1, SERPINE1, ITGAL, VEGFA, PIK3CG, MAPK14

Molecular functions related to allergic rhinitis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	11.5	PF4, CCL7, CCL8, IL8, CCL26, CCL22
2	cytokine receptor activity	GO:004896	10.6	IL17RB, IL13RA2, IL12RB2, IL12RB1, IL12B, IL28RA
3	heparin binding	GO:008201	10.1	ABP1, ELANE, TGFBR3, PRG2, KNG1, LTF
4	growth factor activity	GO:008083	9.9	IL9, NTF3, PPBP, NGF, AGT, TYMP
5	cytokine activity	GO:005125	9.7	ADIPOQ, CSF2, OSM, TSLP, EDN1, SPP1
6	transmembrane signaling receptor activity	GO:004888	9.4	EGFR, TLR2, TLR3, TLR4, SLAMF1, NGFR
7	protein homodimerization activity	GO:042803	8.1	NR3C1, NOD1, NOS2, NFKB1, ABP1, TGFB1
8	protein binding	GO:005515	4.7	NOD1, NOD2, NOS1, NOS2, NLRP3, NGFR