MCID: ALL003
MIFTS: 64

Allergic Rhinitis malady

Respiratory diseases, Immune diseases categories
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Summaries for Allergic Rhinitis

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8Disease Ontology, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat red and watery eyes dark circles under the eyes your health care provider may diagnose hay fever based on a physical exam and your symptoms. sometimes skin or blood tests are used. taking medicines and using nasal sprays can relieve symptoms. you can also rinse out your nose, but be sure to use distilled or sterilized water with saline. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases

MalaCards: Allergic Rhinitis, also known as hay fever, is related to rhinitis and asthma. An important gene associated with Allergic Rhinitis is IL13 (interleukin 13), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The compounds lte4 and unicap have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Disease Ontology:8 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

Wikipedia:65 Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as... more...

Description from OMIM:47 607154

Aliases & Classifications for Allergic Rhinitis

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Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Aliases & Descriptions:

allergic rhinitis 8 47 10 45 62
hay fever 8 34 62
allergic rhinitis due to animal hair and dander 8
allergic rhinitis, susceptibility to 9
allergic rhinitis due to pollen 8
non-seasonal allergic rhinitis 8
allergic rhinitis due to food 8
seasonal allergic rhinitis 8
perenial allergic rhinitis 8
rhinitis allergic seasonal 45
hay fever - pollens 8
allergy to pollen 8
atopic rhinitis 8
pollenosis 8
pollinosis 8


External Ids:

Disease Ontology8 DOID:4481
NCIt40 C34987
SNOMED-CT58 38103000
OMIM47 607154
ICD1025 J30.1

Related Diseases for Allergic Rhinitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1rhinitis32.4IGES, IGHE, RNASE3, EPX, CCL11, IL4
2asthma31.9IL13, CCL11
3conjunctivitis31.0IGES, IGHE, RNASE3, HRH1
4urticaria31.0IGHE, RNASE3, HRH1
5sinusitis31.0IGES, IGHE, IL5, RNASE3, CCL11
6otitis media30.8RNASE3, IGHE, IGES, CCL11
7common cold30.8CCL11, RNASE3
8atopy30.7HAVCR1, IGES, IL13, IL9, IL4R, IL5
9eosinophilia30.7EPX, RNASE3, NGF, IGHE, IGES, CCL17
10allergic conjunctivitis30.6IGHE, RNASE3, CCL11, IL4, IL5, IL13
11allergic asthma30.6IL4R, IL17A, IL5, IL4, CCL13, CCL11
12allergic bronchopulmonary aspergillosis30.5IL5, IGHE, IGES, IL4
13atopic dermatitis30.5IL4, CCL13, CCL11, CCL17, NGF, RNASE3
14dermatitis30.5IL17A, IL13, IGES, IGHE, CCL17, CCL11
15cystic fibrosis30.4RNASE3, IL9, IGES, CCL17, IL17A
16giant papillary conjunctivitis30.3IL5, CCL11, RNASE3
17chronic rhinitis30.3RNASE3, HRH1
18churg-strauss syndrome30.3RNASE3, IL5
19keratoconjunctivitis30.3RNASE3, CCL11, IL5, IL13
20graves' disease30.3IL4R, IL13, IGES, IL4
21tuberculosis30.2EPX, IL4, IGES, IL4R, IL17A
22food allergy30.1IL5, IL13, RNASE3, EPX, CCL11, IL4
23vernal keratoconjunctivitis30.1IL4, IL5, IL13, IGHE, IGES, NGF
24leukemia30.1IL17A, EPX, HRH1, IL9, CCL11, IL4
25blindness10.8
26vasomotor rhinitis10.5
27endotheliitis10.5
28neuronitis10.4
29nasopharyngitis10.4
30adenoiditis10.4
31neurodermatitis10.3
32tonsillitis10.3
33aspergillosis10.3
34migraine10.3
35pulmonary function10.3
36bronchitis10.1RNASE3
37folliculitis10.1CCL11
38malaria10.1HRH1
39netherton syndrome10.1
40lung cancer10.1
41eosinophilic esophagitis10.1CCL11, IL5
42attention deficit hyperactivity disorder10.1
43pulmonary tuberculosis10.1
44obstructive sleep apnea10.1
45chronic fatigue syndrome10.1
46klippel-feil syndrome10.1
47multinodular goiter10.1
48common variable immunodeficiency10.1
49empty sella syndrome10.1
50cough variant asthma10.1

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to allergic rhinitis

Symptoms for Allergic Rhinitis

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47OMIM
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Clinical features from OMIM:

607154

Drugs & Therapeutics for Allergic Rhinitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Allergic Rhinitis

Search NIH Clinical Center for Allergic Rhinitis

Genetic Tests for Allergic Rhinitis

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Anatomical Context for Allergic Rhinitis

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33MalaCards
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MalaCards organs/tissues related to Allergic Rhinitis:

33
Skin, Eye, Testes, T cells, Endothelial, B cells, Lung, Tonsil, Bone, Nk cells, Monocytes, Heart, Lymph node, Thymus, Liver, Bone marrow

Animal Models for Allergic Rhinitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Allergic Rhinitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7FOXJ1, IL4, IL5, IL17A, IL4R, IL9
2MP:00053768.4NGF, IL4, IL5, IL17A, IL4R, IL9
3MP:00053888.3HAVCR1, FOXJ1, CCL24, CCL11, IL4, IL5
4MP:00053977.3CCL24, CCL17, EPX, IGHE, HAVCR1, CCL11
5MP:00053877.0HRH1, HAVCR1, IGHE, EPX, CCL17, CCL24

Publications for Allergic Rhinitis

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52PubMed
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Articles related to Allergic Rhinitis:

(show top 50)    (show all 1104)
idTitleAuthorsYear
1
Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis. (23278877)
2013
2
A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoate aqueous nasal spray in patients with perennial allergic rhinitis. (24079722)
2013
3
Effects of dietary habits and risk factors on allergic rhinitis prevalence among Turkish adolescents. (23820188)
2013
4
Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis. (24067337)
2013
5
Clara cell 10-kDa protein inhibits T(H)17 responses through modulating dendritic cells in the setting of allergic rhinitis. (23273949)
2013
6
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. (23346908)
2013
7
Sequential engagement of FcI/RI on Mast Cells and Basophil Histamine H(4) Receptor and FcI/RI in Allergic Rhinitis. (23241885)
2013
8
Interleukin-4 receptor I+-chain polymorphisms and susceptibility to allergic rhinitis: a meta-analysis. (24337880)
2013
9
Comparison of mometasone furoate monohydrate (Nasonex) and fluticasone propionate (Flixonase) nasal sprays in the treatment of dust mite-sensitive children with perennial allergic rhinitis. (23597528)
2013
10
Safety and efficacy of Nasya/Prevalin in reducing symptoms of allergic rhinitis. (24279907)
2013
11
High-intensity focused ultrasound for the treatment of allergic rhinitis using nasal endoscopy. (23251291)
2013
12
The association between polymorphisms in the MRPL4 and TNF-I+ genes and susceptibility to allergic rhinitis. (23472126)
2013
13
A critical role of IL-33 in experimental allergic rhinitis. (22460070)
2012
14
Targeting the priming response: intranasal steroid therapy for allergic rhinitis. (22530547)
2012
15
The burden of allergic rhinitis (AR) in Canada: perspectives of physicians and patients. (22656186)
2012
16
Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. (23040884)
2012
17
HIF-1I+ inhibition reduces nasal inflammation in a murine allergic rhinitis model. (23133644)
2012
18
Diminished levels of nasal S100A7 (psoriasin) in seasonal allergic rhinitis: an effect mediated by Th2 cytokines. (22230654)
2012
19
Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model. (23554753)
2012
20
Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells. (22687252)
2012
21
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
22
A preliminary study on the regulation mechanism of p38MAPK on MUC5AC in allergic rhinitis]. (22239058)
2011
23
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
24
Development of a questionnaire to assess experience and preference of intranasal corticosteroids in patients with allergic rhinitis. (22915972)
2011
25
Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma. (22289536)
2011
26
Variability of the L-Histidine decarboxylase gene in allergic rhinitis. (20608921)
2010
27
Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. (20482305)
2010
28
Peripheral Th-17 cells in allergic rhinitis: New evidence. (19925886)
2010
29
A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. (19222422)
2009
30
Does pregnancy-associated plasma protein A have a role in allergic rhinitis? (18588751)
2008
31
Leukotrien antagonists in the treatment of allergic rhinitis and comorbidities]. (19058495)
2008
32
Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]. (18260253)
2007
33
Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis. (17091279)
2007
34
TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitis. (17982230)
2007
35
Expression of interleukin 4 and 13 measured in patients with allergic rhinitis]. (17633285)
2007
36
Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. (17181111)
2006
37
Suppressive effect of fluticasone propionate on MMP expression in the nasal mucosa of allergic rhinitis patients in vivo. (16900772)
2006
38
Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. (17072057)
2006
39
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
40
Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between upper and lower airways. (16734115)
2004
41
The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance]. (12412419)
2002
42
Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. (10768732)
2000
43
In vivo expression of signal transducer and activator of transcription factor 6 (STAT6) in nasal mucosa from atopic allergic rhinitis: effect of topical corticosteroids. (10606935)
2000
44
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
45
Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis]. (9585822)
1998
46
Suppressor T cell subsets in allergic rhinitis patients. (8973725)
1996
47
The influence of 5-lipoxygenase inhibition in allergic rhinitis. (7613199)
1995
48
Proinflammatory cytokines in allergic rhinitis. (7537566)
1995
49
Neuropeptides of the nasal innervation and allergic rhinitis]. (7526427)
1994
50
Humoral response to subcutaneous, oral, and nasal immunotherapy for allergic rhinitis due to Dermatophagoides pteronyssinus. (7755664)
1993

Variations for Allergic Rhinitis

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Expression for genes affiliated with Allergic Rhinitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Rhinitis

Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for genes affiliated with Allergic Rhinitis

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Sources:
50PathCards, 54R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 60Thomson Reuters, 53QIAGEN, 55Reactome
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Pathways related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL4, IL4R
29.9IL13, IL5, IL4
39.9IL4, IL5, IL13
49.9CCL11, IL4, IL5
59.9IL4R, IL5, IL4
69.9IL4, IL5, IL4R
7
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.9IL9, IL4R, IL4
8
Show member pathways
9.8IL4R, IL17A, IL4
9
Show member pathways
9.8CCL13, CCL11, CCL24
109.7IL4, IL5, IL9, IL13
119.7IL13, IL9, IL5, IL4
12
Show member pathways
9.6IL9, IL4R, IL4, CCL13
13
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.6IGHE, CCL11, IL4, IL4R
14
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.6IGHE, IL4, IL5, IL13
15
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.6IL4, IL5, IL17A, IL9
169.5IL4, IL5, IL4R, IL9, IL13
17
Show member pathways
Type III interferon signaling38
9.5IL13, IL9, IL4R, IL5, IL4
18
Show member pathways
9.5IL4, IL5, IL17A, IL4R, IL13
199.2IGHE, CCL17, CCL11, IL4, IL5, IL4R
20
Show member pathways
9.1CCL13, CCR8, CCL11, CCL24, CCL17
21
Show member pathways
9.1CCL13, CCR8, CCL11, CCL24, CCL17
22
Show member pathways
9.1CCL17, CCL24, CCL11, CCR8, CCL13
23
Show member pathways
8.9RNASE3, EPX, CCL11, IL4, IL5, IL4R
24
Show member pathways
8.5CCL17, CCL24, CCL11, CCL13, IL4, IL5
25
Show member pathways
8.1CCL17, IL13, IL9, IL4R, IL5, IL4
26
Show member pathways
8.1CCL17, CCL24, CCL11, CCR8, CCL13, IL4
27
Show member pathways
8.1IL9, IL4R, IL5, IL4, CCL13, CCR8
28
Show member pathways
7.9IL13, CCL17, CCL24, CCL11, CCR8, CCL13

Compounds for genes affiliated with Allergic Rhinitis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 24HMDB
See all sources

Compounds related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1lte44510.0RNASE3, EPX, CCL11, IL5
2unicap4510.0IGHE, RNASE3, IL5, CCL11
3omalizumab45 1111.0IL5, IL13, IL4, IGHE
4pranlukast45 29 1111.9RNASE3, IL5, IL4, CCL11
5ltc4459.9RNASE3, EPX, CCL11, IL5, IL13
6ovomucoid459.9IL5, IL4, IL13, IGHE
7rolipram45 61 2911.8CCL11, IL4, IL5, IL13, EPX
8praziquantel45 1110.8RNASE3, IL13, IL5, IL4, IGHE
9salmeterol45 51 29 1112.8RNASE3, EPX, CCL11, IL4, IL5, IL13
10il 10459.8IL13, IL4R, IL5, IL4, CCL17
11anti-histamine459.8RNASE3, IGHE, CCL11, HRH1
12levocetirizine459.7HRH1, IL4, CCL11
13theophylline45 29 24 1112.7IL5, IL13, NGF, EPX, RNASE3
14desloratadine45 1110.7IGHE, HRH1, IL13, IL4
15ltd4459.7IL5, HRH1, IL13, RNASE3
16salbutamol45 51 29 24 1113.7EPX, CCL11, IL5, RNASE3, IGHE, IL13
17pgd2459.7IL5, IL13, EPX, IGHE, RNASE3, CCL11
18montelukast45 51 29 1112.7CCL11, IL4, IL5, IL13, IGHE, RNASE3
19fluticasone propionate45 51 61 1112.6IGHE, IL5, RNASE3, CCL11, IL4, IL13
20nedocromil sodium459.6IL4, RNASE3, IL5, HRH1, IGHE
21azelastine45 1110.6RNASE3, IL4, IL5, HRH1, IGHE
22sodium cromoglycate459.5EPX, CCL11, IL5, HRH1, RNASE3, IGHE
23cetirizine45 29 24 1112.5IGHE, EPX, RNASE3, CCL11, IL5, HRH1
24prednisolone45 29 1111.5NGF, CCL11, IL5, IL13, EPX, RNASE3
25budesonide45 51 1111.5IGHE, RNASE3, EPX, CCL11, IL4, IL5
26leukotriene b445 61 2411.5IL5, CCL11, EPX, RNASE3, IL13
27ionomycin459.5CCL11, IL4, IL5, IL17A, IL4R, IL9
28ketotifen45 1110.5IGHE, RNASE3, CCL11, IL5, HRH1, EPX
29ccl445 2910.5CCL17, IL13, CCR8, CCL11, IL17A
30capsaicin45 2910.4IGHE, HRH1, RNASE3, IL5, NGF
31ccl345 2910.4IL13, CCL11, CCL24, CCL17, CCR8
32aspirin45 51 29 2412.2CCL11, IL13, RNASE3, HRH1, NGF, IGES
33tacrolimus45 51 1111.2CCL11, CCL17, IL5, IL13, HRH1, IL4
34pge2459.1IL17A, RNASE3, EPX, HRH1, IL13, CCL11
35actinomycin d459.0NGF, CCL24, CCL11, IL13, IL4R, IL17A
36sb 20358045 6110.0NGF, IL13, IL5, IL4, CCL11, IL17A
37indomethacin45 29 61 1112.0IGHE, NGF, CCL11, IL4, IL5, IL17A
38thymidine45 249.9IL4R, IL9, IL13, HRH1, NGF, IL17A
39methacholine45 51 1110.9IL13, IL9, IL17A, IL5, IL4, CCL11
40vegf458.9IGHE, IL13, IL17A, IL5, NGF, RNASE3
41adenylate458.8HRH1, IL13, IL5, IL4, RNASE3, NGF
42steroid458.8CCL24, IL13, IL4R, IL17A, CCL13, EPX
43nitric oxide45 24 1110.6HRH1, IL13, IL9, IL17A, CCL11, IGES
44tyrosine458.5IL13, IL9, IL4R, IL17A, IL5, IL4
45tarc458.2CCL17, IGHE, CCL13, CCR8, IL5, IL4R
46cyclosporin a45 29 6110.2IGES, IGHE, HRH1, IL13, IL4R, IL17A
47allergens458.1IGHE, RNASE3, EPX, CCL17, CCL11, IGES
48dexamethasone45 51 29 1111.0CCL17, IL4R, HRH1, CCL13, IL17A, EPX
49rantes457.8HRH1, IL13, IL9, IL4R, IL17A, IL5
50histamine45 29 249.7IGES, IGHE, HRH1, IL13, IL9, IL4R

GO Terms for genes affiliated with Allergic Rhinitis

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16Gene Ontology
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Cellular components related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.0NGF, RNASE3, CCL17, CCL11, IL5, IL13
2extracellular spaceGO:0056157.8IL13, NGF, CCL17, CCL24, CCL11, CCL13

Biological processes related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage activationGO:04303210.3IL4R, IL13
2regulation of proton transportGO:01015510.3IL13, IL4
3defense response to protozoanGO:04283210.1IL4R, IL4
4positive regulation of B cell proliferationGO:03089010.1IL13, IL5, IL4
5positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.1IL5, IL4, NGF
6response to nicotineGO:03509410.0NGF, IL13
7positive regulation of Rac GTPase activityGO:03285510.0CCL11, CCL24
8cytoskeleton organizationGO:0070109.9CCL13, CCL11, CCL24
9regulation of cell shapeGO:0083609.9CCL24, CCL11, CCL13
10response to radiationGO:0093149.8NGF, CCL11
11eosinophil chemotaxisGO:0482459.7CCL24, CCL11, CCL13, HRH1
12cell-cell signalingGO:0072679.5CCL17, CCL24, CCL13, IL17A, IL13
13signal transductionGO:0071659.4IL13, IL4R, CCL13, CCL11, CCL24
14chemotaxisGO:0069359.2CCL17, CCL24, CCL11, CCR8, CCL13, IL4
15inflammatory responseGO:0069548.4IL13, IL9, IL17A, IL5, CCL13, CCL11
16immune responseGO:0069557.9IL13, IGHE, CCL17, IL9, IL4R, IL17A

Molecular functions related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.7IL9, IL5, IL4, NGF
2chemokine activityGO:0080099.4CCL13, CCL11, CCL24, CCL17
3cytokine activityGO:0051259.1IL4, IL5, IL17A, IL9, IL13

Products for genes affiliated with Allergic Rhinitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Rhinitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet