MCID: ALL003

Summaries for Allergic Rhinitis

Sources:
6Disease Ontology, 23MedlinePlus, 44Wikipedia, 33OMIM, 22MalaCards
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MedlinePlus: Each spring, summer, and fall, trees, weeds and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat dark circles under the eyes taking medicines, using nasal sprays and rinsing out your nose can relieve symptoms. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases23

MalaCards: Allergic Rhinitis, also known as hay fever, is related to asthma and rhinitis. An important gene associated with Allergic Rhinitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Akt Signaling and RAR-Gamma-RXR-Alpha Degradation. The drugs beclomethasone and brompheniramine and the compounds allergens and methacholine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and small intestine, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology: A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.6

Wikipedia: Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as...44 more...

OMIM: 607154

Aliases & Descriptions for Allergic Rhinitis

Sources:
6Disease Ontology, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 27NCIt
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Aliases & Descriptions:

allergic rhinitis 6 8 33 32
hay fever 6 23 43
allergic rhinitis due to animal (cat) (dog) hair and dander 6
allergic rhinitis due to pollen (disorder) 6
seasonal allergic rhinitis (disorder) 6
allergic rhinitis due to pollen 6
non-seasonal allergic rhinitis 6
allergic rhinitis due to food 6
rhinitis, allergic, perennial 43
allergic rhinitis (disorder) 43
allergy to pollen (disorder) 6
perenial allergic rhinitis 6
seasonal allergic rhinitis 6
rhinitis allergic seasonal 32
hay fever - pollens 6
hypersensitivity 43
atopic rhinitis 6
pollenosis 6
pollinosis 6
rhinitis 43

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SNOMED-CT40 38103000

Related Diseases for Allergic Rhinitis

Sources:
13GeneCards, 14GeneDecks
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Diseases related to allergic rhinitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 969)
idRelated DiseaseScoreTop Affiliating Genes
1asthma38.9SCGB1A1, SCGB3A2, IL12B, IL13, CCL11, HNMT
2rhinitis36.2PIP, PIK3CG, PDCL, PDE4A, RELA, RENBP
3atopic dermatitis34.9PDE4A, KITLG, SELE, VIP, VCAM1, BDNF
4chronic rhinitis33.9MPO, CALCA, HRH1, RNASE3, EDN1, EPX
5eosinophilia33.7PDE4A, SFTPA1, SFTPA2, SFTPD, VCAM1, CLC
6allergic asthma33.3SERPINE1, VCAM1, BDNF, BCL2, SCGB1A1, MS4A2
7eczema33.0BTK, SELE, VIP, MS4A2, MPO, CD79A
8vernal keratoconjunctivitis31.8VCAM1, MMP9, IL13, IL3, IL4, IL5
9extrinsic allergic alveolitis31.6SFTPD, CD14, FCER2, IL18, IL1A, IL8
10allergic conjunctivitis31.5IL13, IL4, IL5, CCL11, IGHE, HRH1
11allergic bronchopulmonary aspergillosis31.5SFTPD, IL4, IL5, MBL2, IGES, IGHE
12bronchial asthma31.4KITLG, SFTPD, SELE, VIP, VEGFA, VCAM1
13vasomotor rhinitis31.3VIP, IL10, IL13, IL16, CALCA, TAC1
14churg-strauss syndrome31.2CHIA, MPO, IL10, IL13, IL2RA, IL4
15urticaria30.8KITLG, SELE, VEGFA, VCAM1, MS4A2, CD79A
16food allergy30.4FOXP3, IL13, IL4, IL5, CCL11, IGES
17t cell deficiency30.4BTK, VCAM1, BCL2, CD79A, CD4, FCGR2A
18atopy30.3RELA, KITLG, VEGFA, KDR, SCGB1A1, MS4A2
19hypersensitivity reaction type iv disease30.0SELE, IL4, IGHE, IFNG, ICAM1, TF
20polycythemia vera29.9PIK3CG, KITLG, SERPINE1, MPO, CD79A, IL3
21keratoconjunctivitis29.9RELA, VIPR1, VEGFA, VCAM1, MUC5AC, CD79A
22otitis media29.8SFTPA1, SFTPA2, SERPINE1, VCAM1, MUC1, MUC2
23was-related disorders29.7BDNF, LEP, CHKB, MPO, IL2RA, IL6
24fibromyalgia29.7SERPINE1, BGLAP, BDNF, CHKB, IL10, IL1B
25aspergillosis29.7SFTPA1, SFTPA2, SFTPD, CD79A, CD4, IL10
26intrinsic asthma29.6FCER2, IL3, IL4, IL5, CCL7, CCL5
27hypersensitivity reaction type ii disease29.5PDE4A, VIP, VCAM1, CD28, CD79A, CD86
28common cold29.2CHIA, IL1R1, IL5, IL8, CCL11, ICAM1
29rheumatoid arthritis29.0CD40, IL10, IL1B, IL1RN, IL23A, HLA-DQA1
30polycythemia29.0PIK3CG, KITLG, SERPINE1, VEGFA, MPO, CD79A
31immunodeficiency28.9BTK, VIP, CD28, CD79A, CD4, CD40LG
32essential thrombocythemia28.8SELE, SERPINE1, BGLAP, MPO, IL3, TNF
33arthritis28.6VIP, IL17A, IL1A, IL1B, IL6, IL8
34arthus reaction28.6FCGR1A, ALOX5, HRH1, HMOX1, TNF, ELANE
35pulmonary function28.5LEP, CHIA, MPO, CD14, IL10, IL13
36angioedema28.5BDKRB2, MS4A2, MME, IL5, IL6, IGHE
37cutaneous t cell lymphoma28.4SELE, ITGAL, IL15, IL2RA, IL4, IL5
38tuberculosis28.4IL10, IL12B, IL1B, IL1RN, IL4, MBL2
39bullous pemphigoid28.3CD79A, ITGAL, FLG, FCER2, IL13, IL5
40irritable bowel syndrome28.3VIP, LEP, MPO, CD79A, CD40LG, IL10
41cough variant asthma28.3IL10, IL4, IL5, IGHE, RNASE3, ACE
42chronic fatigue syndrome28.2VIP, CD4, IL10, IL1R1, IL4, IL6
43graves' disease28.1RETN, KITLG, SELE, VCAM1, BGLAP, BCL2
44mastocytosis27.9KITLG, BGLAP, BCL2, MPO, FCER2, IL13
45omenn syndrome27.8IL10, IL1RN, IL4, IL5, IGHE, IFNG
46breast cancer27.5VEGFA, KDR, BCL2, MMP9, GSTP1, IL10
47blindness27.2PIK3CG, PDE4A, SELE, SERPINF1, SERPINE1, VIP
48systemic lupus erythematosus27.1SELE, VIP, VCAM1, BDNF, MPO, CD28
49sinusitis26.9RELA, SFTPD, BTK, SERPINE1, VEGFA, VCAM1
50erythema multiforme26.9CD79A, CCL22, CCL17, CCL1, CCR3, CCL5

Graphical network of the top 20 diseases related to allergic rhinitis:



Graphical network of diseases related to allergic rhinitis

Clinical Features for Allergic Rhinitis

Sources:
33OMIM
See all sources
Clinical features from OMIM: 607154

Drugs & Therapeutics for Allergic Rhinitis

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for allergic rhinitis

Drug clinical trials:

Search ClinicalTrials for allergic rhinitis

Search NIH Clinical Center for allergic rhinitis

Search CenterWatch for allergic rhinitis

Inferred drug relations via UMLS/NDF-RT:

43 28 acrivastine, astemizole, azatadine, azatadine maleate, azelastine, azelastine hydrochloride, beclomethasone, beclomethasone dipropionate, bromodiphenhydramine, bromodiphenhydramine hydrochloride, brompheniramine, brompheniramine maleate, budesonide, carbinoxamine, carbinoxamine maleate, cetirizine, cetirizine hydrochloride, chlorcyclizine, chlorcyclizine hydrochloride, chlorothen maleate, chlorpheniramine, chlorpheniramine maleate, chlorpheniramine polistirex, chlorpheniramine tannate, clemastine, clemastine fumarate, cromolyn, cromolyn sodium, cyproheptadine, cyproheptadine hydrochloride, cyproheptadine hydrochloride monohydrate, desloratadine, dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], dexbrompheniramine, dexbrompheniramine maleate, dexchlorpheniramine, dexchlorpheniramine maleate, diphenhydramine, diphenhydramine citrate, diphenhydramine hydrochloride, doxylamine, doxylamine succinate, ephedra, ephedrine, ephedrine hydrochloride, ephedrine sulfate, ephedrine tannate, fexofenadine, fexofenadine hydrochloride, flunisolide, fluticasone, fluticasone furoate, fluticasone propionate, guaifenesin, hyoscyamine, hyoscyamine hydrobromide, hyoscyamine sulfate, ipratropium, ipratropium bromide, loratadine, methapyrilene, methapyrilene hydrochloride, methdilazine, methdilazine hydrochloride, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, mometasone, mometasone furoate, mometasone furoate monohydrate, montelukast, montelukast sodium, naphazoline, naphazoline hydrochloride, oxymetazoline, oxymetazoline hydrochloride, phenindamine, phenindamine tartrate, phenylpropanolamine, phenylpropanolamine hydrochloride, phenyltoloxamine, phenyltoloxamine citrate, phenyltoloxamine dihydrogen citrate, phenyltoloxamine resin complex, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], promethazine, promethazine hydrobromide, promethazine hydrochloride, pseudoephedrine, pseudoephedrine hydrochloride, pseudoephedrine sulfate, pyrilamine, pyrilamine maleate, pyrilamine tannate, triamcinolone, triamcinolone acetonide, triamcinolone acetonide pwdr [va product], triamcinolone diacetate, triamcinolone hexacetonide, trimeprazine, trimeprazine tartrate, tripelennamine, tripelennamine citrate, tripelennamine hydrochloride

Genetic Tests for Allergic Rhinitis

Anatomical Context for Allergic Rhinitis

Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to allergic rhinitis:

22
Bone marrow, Thymus, Small intestine, Liver, Adrenal gland, Skin, Nk cells, T cells, B cells, Endothelial, Bronchial epithelium

Phenotypes for genes affiliated with Allergic Rhinitis

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to allergic rhinitis:

25 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539712.0BTK, BDKRB2, BCL2, CD28, CD3D, CD86
2respiratory system phenotypeMP:000538811.4SFTPD, BDNF, SCGB1A1, LGR5, CD14, FOXJ1
3endocrine/exocrine gland phenotypeMP:000537910.6VIPR1, BDKRB2, LGR5, CD40LG, AQP5, IFNG
4renal/urinary system phenotypeMP:00053679.8PDC, RENBP, CLCN3, BDKRB2, BCL2, SCGB1A1
5normal phenotypeMP:00028739.7RELA, SELE, VIP, VEGFA, BDKRB2, BDNF
6integument phenotypeMP:00107719.6PIK3CG, RELA, KITLG, BTK, BDNF, BCL2
7liver/biliary system phenotypeMP:00053709.4RETN, VEGFA, CLCN3, IL12RB2, IL1R1, IL6
8immune system phenotypeMP:00053879.3PDE4A, BTK, VIPR2, BPIFA1, CLCN3, BDKRB2
9behavior/neurological phenotypeMP:00053869.0SELE, VIP, VIPR1, VIPR2, CLCN3, BDKRB2
10nervous system phenotypeMP:00036318.8PDC, PDE4A, RELA, KITLG, SERPINF1, CLCN3
11no phenotypic analysisMP:00030128.7VEGFA, VCAM1, BDNF, LGR5, MUC1, T
12digestive/alimentary phenotypeMP:00053818.1KITLG, BTK, SERPINF1, VIPR1, VEGFA, CLCN3
13reproductive system phenotypeMP:00053897.9SERPINF1, VIP, VIPR2, VEGFA, CLCN3, BDKRB2
14mortality/agingMP:00107687.9RELA, KITLG, SFTPD, BTK, SELE, SERPINE1
15growth/size phenotypeMP:00053787.8PIK3CG, RELA, KITLG, SFTPD, BTK, SELE
16adipose tissue phenotypeMP:00053757.4RETN, SERPINE1, VIPR2, CLCN3, BDKRB2, BCL2
17skeleton phenotypeMP:00053906.7PIK3CG, RELA, KITLG, VEGFA, CLCN3, BDKRB2
18vision/eye phenotypeMP:00053915.9PDC, RELA, KITLG, SELE, SERPINF1, VEGFA
19tumorigenesisMP:00020065.5KITLG, BTK, SERPINE1, BCL2, SCGB1A1, LGR5
20cellular phenotypeMP:00053845.4PIK3CG, RELA, KITLG, BTK, SELE, VIPR1
21homeostasis/metabolism phenotypeMP:00053765.1PIK3CG, PDC, RELA, RENBP, RETN, KITLG
22muscle phenotypeMP:00053694.5PIK3CG, PDC, RELA, VEGFA, KDR, BCL2
23cardiovascular system phenotypeMP:00053854.3PIK3CG, PDC, PDE4A, RELA, KITLG, SELE

Publications for genes affiliated with Allergic Rhinitis

Sources:
35PubMed
See all sources

Articles related to allergic rhinitis:

(show top 50)    (show all 511)
idTitleAuthorsYearAffiliating Genes
1Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore. (21723144)Andiappan A.K.... Chew F.T.2011BDNF
2Association pattern of interleukin-1 receptor-associa ted kinase-4 gene polymorphisms with allergic rhinitis in a Han Chinese populat ion. (21738793)Zhang Y.... Zhang L.2011IRAK4
3Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farin ae and Japanese cedar pollen. (20128182)Suzuki K.... Izuhara K.2010RNASE3
4The expression of IL-23 in nasal mucosa of allergic rhinitis patients and its significance]. (20873540)Liu Y.... Cui Y.2010IL23A
5Increased expression of acidic mammalian chitinase an d chitotriosidase in the nasal mucosa of patients with allergic rhinitis. (20422678)Cho W.S.... Lee S.H.2010CHIT1, CHIA
6Expression and clinical significance of calcium-acti vated chloride channel and mucins in nasal mucosa with allergic rhinitis (20464982)Wu W.... Wang L.2010CLCA1, MUC5AC
7FcI/RI levels and frequencies of peripheral blood dend ritic cell populations in allergic rhinitis. (20650300)Lundberg K.... Lindstedt M.2010FCGR1A
8Three-year follow-up study of allergen-induced in vit ro cytokine and signalling lymphocytic activation molecule mRNA responses in pe ripheral blood mononuclear cells of allergic rhinitis patients undergoing speci fic immunotherapy. (19571569)Nieminen K.... Savolainen J.2009IL18, IL4, IFNG
9Nasal inflammatory mediators and specific IgE product ion after nasal challenge with grass pollen in local allergic rhinitis. (19796796)RondA^n C.... Blanca M.2009IGHE
10Soluble serum HLA-G and HLA-A, -B, -C molecules in pa tients with seasonal allergic rhinitis exposed to pollens. (19410660)Ciprandi G.... Puppo F.2009HLA-G
11Expression and significance of SP-A in nasal mucosa of allergic rhinitis and nasal polyp (19894557)Deng Y.... Xiao B.2009SFTPA1
12Gene expression profiles of nasal polyps associated with allergic rhinitis. (19027509)Wu J.... Jingping F.2009CCL20
13Relationship between the IL-12B promoter polymorphism and allergic rhinitis, familial asthma, serum total IgE, and eosinophil level in asthma patients. (19274925)Tug E.... Yuce H.2009IL12B, IGHE
14Therapeutic effect of montelukast, a cysteinyl leukotriene receptor 1 antagonist, on Japanese patients with seasonal allergic rhinitis. (18566548)Okubo K.... Baba K.2008CYSLTR1
15Immunoglobulin domain and mucin domain-1 in helper T lymphocytes in allergic rhinitis (19159567)Wu W.K.... Zhao C.Q.2008HAVCR1
16Expression of substance P, vasoactive intestinal peptide and heat shock protein 70 in nasal mucosal smears of patients with allergic rhinitis: investigation using a liquid-based method. (18282334)Chalastras T.... Athanassiadou P.2008HSPA8, VIP
17The Allergic Rhinitis and its Impact on Asthma system: a new classification of allergic rhinitis and nasal responsiveness. (17498329)Sheahan P.... Costello R.W.2008KNG1
18Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis (18260253)Gawlik R.... Jawor B.2007EDN1
19T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy. (17156343)Francis J.N.... Till S.J.2007CCR3
20Relation between IgE levels and infections in patients with allergic rhinitis and asthma (16568707)Gameros Gardea R.A.... JimAcnez J.2005IGHE
21Correlations between plasma levels of IL-18, IL-4, IFN-gamma, IgE and ECP in the patients with seasonal allergic rhinitis and their clinical implications (15934281)Lin X.... Xie H.2005IL18, IL4, RNASE3
22Seasonal non-allergic rhinitis (SNAR)--a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis. (16008061)WedbAock A.... Malcus I.2005IGHE
23Intracellular production of IL-2, IL-4 and IFN-gamma by peripheral blood CD3+ cells in intermittent allergic rhinitis. (15750716)GlA1ck J.... Mazur B.2005IL4, IFNG
24CD34+ cell and interleukin 5 and eosinophil in the peripheral blood of allergic rhinitis patients (16200968)Zhang H.... Guo C.2005IL5
25Association between polymorphisms of the angiotensin-converting enzyme and angiotensinogen genes and allergic rhinitis in a Korean population. (15112973)Kim J.J.... Lee J.H.2004ACE, AGT
26Efficacy, chemistry and pharmacology of chinese herba l medicine for allergic rhinitis. (15180574)Xue C.C.... Story D.F.2004IGHE
27Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen. (15298558)Cheng L.... Shirakawa T.2004ADAM33
28Determination of interleukins and IgG4 in patients with allergic rhinitis with and without immunotherapy (15491078)VelA!zquez B.L.... Feria A.J.2004IL4, IFNG, IL5
29Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma. (15120189)Gentile D.A.... Skoner D.P.2004TGFB1, TNF, IL6
30Detection of eosinophil cationic protein and E-selectin in serum and nasal lavage fluid in patients with allergic rhinitis (12889102)Hong S.L.... Sun R.2003SELE, RNASE3
31Decreased serum IgE level, decreased IFN-gamma and IL-5 but increased IL-10 production, and suppressed cyclooxygenase 2 mRNA expression in patients with perennial allergic rhinitis after treatment with a new mixed formula of Chinese herbs. (11407311)Yang S.H.... Yu C.L.2001IL5, IGHE
32Mucosal output of eotaxin in allergic rhinitis and its attenuation by topical glucocorticosteroid treatment. (11529904)Greiff L.... Persson C.G.2001CCL11
33Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma. (11251403)Marcucci F.... Coniglio G.2001RNASE3, IGHE
34As-needed use of fluticasone propionate nasal spray reduces symptoms of seasonal allergic rhinitis. (10756223)Jen A.... Naclerio R.2000RNASE3
35Nasal soluble levels of ICAM-1 in allergic rhinitis (10739998)Gilain L.... Caillaud D.2000ICAM1
36Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)Wright E.D.... Hamid Q.1999MAPK1, IL12RB1
37Serum IFN-gamma and IL-10 levels before and after specific immunotherapy in patients with allergic rhinitis. (10568876)Keskin G.... Kinikli G.1999IFNG, IL10
38Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis (9585822)AntAcpara I.... VA!zquez M.1998HRH1
39Ten-year follow-up study of allergen-specific immunoglobulin E and immunoglobulin G4, soluble interleukin-2 receptor, interleukin-4, soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 in serum of patients on immunotherapy for perennial allergic rhinitis. (9496694)Ohashi Y.... Yamada K.1998IL4
40Effect of mometasone furoate on early and late phase inflammation in patients with seasonal allergic rhinitis. (9860036)Frieri M.... Nolop K.B.1998IL6, IL8, IL5
41Soluble adhesion molecules and cytokines in perennial allergic rhinitis. (9723565)Liu C.M.... Cheng Y.K.1998SELE, IL5
42IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis. (9353157)Till S.... Durham S.1997IL5
43The pharmacological basis for the treatment of perenn ial allergic rhinitis and non-allergic rhinitis with topical corticosteroids. (9212861)Meltzer E.O.1997IL6, NR3C1, IFNG
44Chemokines in seasonal allergic rhinitis. (8568122)Kuna P.... Kaplan A.P.1996IL8, CCL5, RNASE3
45Allergen-driven limiting dilution analysis of human IL-4 and IFN-gamma production in allergic rhinitis and clinically tolerant individuals. (8671679)Li Y.... Hayglass K.T.1996IL4, IFNG
46Effect of six-hour exposure to nitrogen dioxide on early-phase nasal response to allergen challenge in patients with a history of seasonal allergic rhinitis. (7499684)Wang J.H.... Davies R.J.1995MPO, IL8, RNASE3
47Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture: responses of subjects with allergic rhinitis and normal controls. (7558124)Imada M.... Hayglass K.T.1995IL4, IFNG
48Allergen-induced changes of B-cell phenotypes in patients with allergic rhinitis. (7535471)Davidsson A.... Hellquist H.B.1994IL4
49Allergic rhinitis to ragweed pollen. II. Modulation of histamine-releasing factor production by specific immunotherapy. (1370511)Brunet C.... Hebert J.1992TPT1
50Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators. (1741538)Sedgwick J.B.... Busse W.W.1991IL5

Expression for genes affiliated with Allergic Rhinitis

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Allergic Rhinitis

Pathways for genes affiliated with Allergic Rhinitis

Sources:
36QIAGEN, 20KEGG, 38Reactome, 41Thomson Reuters, 37R&D Systems, 10EMD Millipore
See all sources

Pathways related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 196)
idPathwayScoreTop Affiliating Genes
1Akt Signaling3611.5PIP, PIK3CG, BTK, CD28, CD4, ITGAL
2RAR-Gamma-RXR-Alpha Degradation3611.3PIP, BTK, IL12A, IL15, IL16, IL23A
3Chemokine signaling pathway2011.2PIK3CG, RELA, ITK, IL8, MAPK1, CCL8
4Immune System3811.1VCAM1, CD79A, CD40, FCGR1A, FCGR3A, IL18
5Jak-STAT signaling pathway2011.0PIK3CG, LEP, IL10, IL12A, IL12B, IL12RB1
6NFAT Signaling and Lymphocyte Interactions3610.9BTK, BCL2, CD3D, CD4, FCER1A, FCER2
7all-trans-Retinoic Acid Signaling in Brain3610.7PIP, BTK, BCL2, IL10, IL12A, IL12B
8Cytokine production by Th17 cells in CF (Mouse model)4110.7RELA, CD14, FOXP3, IL12B, IL12RB1, IL17A
9STAT3 Pathway3610.5PIP, BTK, BCL2, CD28, CD4, IL10
10SOCS Pathway3610.5BTK, BCL2, CD4, IL10, IL12A, IL12B
11PEDF Induced Signaling3610.4PIP, RELA, BTK, SERPINF1, BDNF, BCL2
12Asthma2010.3MS4A2, CD40LG, CD40, FCER1A, IL10, IL13
13Phagosome2010.3SFTPA1, SFTPD, MPO, CD14, FCGR1A, FCGR2A
14PGC1Alpha Pathway3610.3BTK, BCL2, CD4, IL12A, IL12B, IL13
15Intestinal immune network for IgA production2010.2CD28, CD86, CD40LG, CD40, IL10, IL15
16Cytokine-cytokine receptor interaction2010.1KITLG, VEGFA, KDR, LEP, CD40LG, CD40
17Th1 Differentiation3710.0JUN, CD28, CD86, CD4, IL10, IL12A
18African trypanosomiasis209.9SELE, VCAM1, IL10, IL12A, IL12B, IL18
19THC Differentiation Pathway369.9CD28, CD86, IL10, IL12A, IL12B, IL12RB1
20Graft-versus-host disease209.9CD28, CD86, IL1A, HLA-A, HLA-B, HLA-C
21Measles209.9PIK3CG, RELA, CD28, CD3D, IRAK4, IL12A
22Chemokine Signaling369.9JUN, IL8, MAPK14, MAPK1, CCL8, CCL7
23Rho Family GTPases369.9PIP, KITLG, BTK, BDNF, KDR, BCL2
24Amoebiasis209.8RELA, MUC2, CD14, IL12A, IL12B, IL1B
25Hematopoietic cell lineage209.8KITLG, CD3D, CD14, CD4, MME, FCER2
26PAK Pathway369.8PIP, KITLG, BTK, BDNF, KDR, BCL2
27Th17 Differentiation379.7CD28, CD86, CD4, IL12B, IL12RB1, IL17A
28Tec Kinases Signaling369.6KITLG, BTK, BDNF, BCL2, CD28, CD3D
29Autoimmune thyroid disease209.6CD28, CD86, CD40LG, CD40, IL10, IL4
30Glucocorticoid Receptor Signaling369.3BTK, BCL2, JUN, CD4, IL10, IL12A
31Immune response MIF-mediated glucocorticoid regulation109.2RELA, VCAM1, JUN, IL6, IL8, MAPK1
32Immune response_MIF-mediated glucocorticoid regulation419.2RELA, VCAM1, JUN, IL6, IL8, MAPK1
33ERK Signaling369.2PIP, KITLG, BTK, CD3D, ITGAL, IL10
34Endothelin-1 Signaling Pathway369.2PIP, BTK, IL10, IL12A, IL12B, IL13
35Rheumatoid arthritis209.0VEGFA, JUN, CD28, CD86, ITGAL, IL15
36Type I diabetes mellitus209.0CD28, CD86, IL12A, IL12B, IL1A, IL1B
37Immune response MIF in innate immunity response108.7RELA, JUN, CD14, IRAK4, IL1B, IL6
38NF-KappaB (p50-p65) Pathway368.7RELA, KITLG, BDNF, KDR, IRAK4, IL1A
39Toll-like receptor signaling pathway208.7PIK3CG, RELA, JUN, CD86, CD14, CD40
40Antioxidant Action of Vitamin-C368.6PIP, KITLG, BTK, BDNF, KDR, BCL2
41Pertussis208.6RELA, SFTPA1, JUN, CD14, IRAK4, IL10
42JAK-STAT Pathway368.5KITLG, BTK, BDNF, KDR, BCL2, JUN
43Osteoclast differentiation208.3PIK3CG, RELA, BTK, JUN, FCGR1A, FCGR2A
44NF-KappaB Family Pathway368.2RELA, KITLG, BDNF, KDR, IRAK4, IL1A
45TGF-Beta Pathway368.1KITLG, BTK, BDNF, KDR, BCL2, JUN
46MAPK Family Pathway368.1KITLG, BTK, BDNF, KDR, BCL2, JUN
47Leishmaniasis207.7RELA, JUN, IRAK4, FCGR1A, FCGR2A, FCGR3A
48Influenza A207.6PIK3CG, RELA, JUN, IRAK4, IL12A, IL12B
49NFAT in Immune Response367.5KITLG, BTK, BDNF, KDR, JUN, CD28
50Renin-Angiotensin Pathway367.1KITLG, VCAM1, BDNF, KDR, JUN, IL2RA

Compounds for genes affiliated with Allergic Rhinitis

Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 479)
idCompoundScoreTop Affiliating Genes
1allergens32 11.7SFTPD, MS4A2, CD79A, CD86, CD14, CD40LG
2methacholine32 9 9 13.6VIP, MPO, CD79A, CD14, MME, IL13
3ltc432 11.4VIP, IL13, IL3, IL5, CCL11, ALOX5
4ionomycin32 11.3BTK, CD40, FCER2, IL12RB1, IL3, IL5
5thromboxane32 18 12.3PDE4A, ALOX5, ALOX5AP, HRH1, PTGDR, PTGS1
6ccl432 11.2IL12B, IL13, IL15, IL16, IL17A, IL1R1
7salbutamol32 34 9 18 9 15.2PDE4A, KITLG, VIP, VCAM1, CHKB, CD79A
8nadph32 18 11.7CLCN3, BDKRB2, AKT1, HMOX2, CYP3A4, PRG2
9peptidoglycan32 10.6CD14, IL10, IL12B, IL15, IL1B, IL1R1
10thromboxane a232 18 11.6PDE4A, BDKRB2, ALOX5, PTGDR, PTGDR2, PTGS2
11lipid32 10.6PIK3CG, PDC, PDE4A, RETN, KITLG, SFTPD
12threonine32 10.4BTK, BDKRB2, MUC2, MUC5AC, CD4, ITK
13hyaluronic acid32 18 11.4SCGB1A1, MUC1, LCN1, ITGAL, IL13, PTGS1
14mannose32 10.2SFTPD, CLC, PAPPA, CHIT1, CD79A, CD86
15ng-nitro-l-arginine32 10.1PDE4A, VIP, BDKRB2, BDNF, CALCA, NOS1
16isoproterenol32 9 9 12.1PDE4A, ITGAL, IL13, IL1A, IL3, IL5
17endotoxin32 10.0RETN, SFTPD, SCGB1A1, CHKB, CD86, CD14
18agar32 9.9KITLG, MUC1, CD40LG, IL9, AKT1, PTGS1
19pentoxifylline32 9 9 11.9PDE4A, VCAM1, MPO, CD14, IL10, IL12B
20dopamine32 9 18 9 12.7PDE4A, SELE, VIP, BDNF, SCG2, CHKB
21aprotinin32 9 9 11.7VIP, BDKRB2, MMP9, IL1A, IGHE, PPBP
22clozapine32 34 9 9 12.7BDNF, LEP, CHKB, MPO, IL10, IL18R1
23progesterone32 42 9 18 9 13.6PIP, PDE4A, PAPPA, BCL2, SCGB1A1, MME
24superoxide32 18 10.6PDE4A, KITLG, VCAM1, CLCN3, SCG2, CHKB
25chloroquine32 34 9 9 12.6CD79A, CD4, ITGAL, IL10, IL15, IL18
26apocynin32 9.5SELE, VCAM1, MPO, JUN, ICAM1, DYT10
27ribavirin32 34 9 9 12.4VIPR1, LEP, CD40LG, MMP9, IL10, IL18
285-hydroxytryptamine32 9.4BTK, SERPINE1, VIP, SCG2, MME, IL1A
29ascorbic acid32 18 10.3PIK3CG, BGLAP, BDNF, CHKB, CD40LG, MME
30c2ceramide32 9.3PIK3CG, JUN, IL1B, MAPK14, AKT1, TNF
31infliximab32 9 9 11.3SELE, VEGFA, BGLAP, FLG, IL10, IL15
32sulfasalazine32 9 9 10.8SELE, MPO, CD79A, CD40LG, IL12B, IL1A
33simvastatin32 34 42 9 18 9 13.6KITLG, SELE, SERPINE1, VEGFA, VCAM1, BGLAP
34estrogen32 8.5PIP, RETN, SERPINE1, VIP, BGLAP, BDNF
35wortmannin32 42 9.3PIK3CG, PDE4A, KITLG, BTK, VCAM1, BDNF
36n acetylcysteine32 8.2SELE, VCAM1, BDNF, KDR, MUC5AC, CD79A
37lactate32 8.2KITLG, SFTPD, SELE, VIP, VCAM1, BDNF
38diphenyleneiodonium32 8.2SERPINF1, VEGFA, VCAM1, MPO, JUN, IL1B
39cytochalasin d32 42 9.2PIK3CG, KITLG, SELE, VCAM1, ITGAL, MMP9
4012-o-tetradecanoylphorbol 13-acetate32 8.1SCG2, MUC2, CD4, MME, MMP9, FCER2
41butyrate32 8.1KITLG, BCL2, LEP, MUC1, MUC2, MPO
42quercetin32 42 9 18 9 12.0PIK3CG, SELE, VCAM1, BCL2, JUN, MME
43creatinine32 7.9RETN, KITLG, SELE, PAPPA, BDKRB2, BDNF
44norepinephrine32 9 18 9 10.8PDC, PDE4A, RETN, KITLG, SELE, VIP
45mg 13232 42 8.7PIK3CG, KDR, JUN, IL1A, IL1B, IL8
46rosiglitazone32 9 18 9 10.5PIK3CG, RETN, SELE, SERPINE1, VCAM1, LEP
47tamoxifen32 34 9 9 10.3PIP, PDE4A, SELE, VEGFA, VCAM1, BGLAP
48gf 109203x32 42 8.1PIK3CG, KITLG, BTK, VEGFA, JUN, FLG
49paraffin32 6.8PIP, RELA, KITLG, VEGFA, VCAM1, BGLAP
50genistein32 9 18 9 8.0PIK3CG, KITLG, BTK, SELE, SERPINE1, VEGFA

GO Terms for genes affiliated with Allergic Rhinitis

Sources:
12Gene Ontology
See all sources

Cellular components related to allergic rhinitis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5VIPR1, VIPR2, CLCA1, TGFBR3, TACR1, CXCR2
2external side of plasma membraneGO:00989710.0CD28, CD79A, CD86, CD4, CD40LG, CD40
3platelet alpha granule lumenGO:0310939.9TGFB1, TIMP1, PF4, PPBP, ALB, VEGFA
4integral to lumenal side of endoplasmic reticulum membraneGO:0715569.6HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
5cell surfaceGO:0099869.4NOD2, NGFR, ELANE, TLR2, TLR3, TGFB1
6ER to Golgi transport vesicle membraneGO:0125079.4HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
7extracellular spaceGO:0056158.6WNT2B, KNG1, ADIPOQ, MBL2, CCL14, CCL5
8extracellular regionGO:0055768.5CCL7, PTGDS, SPP1, NTF3, PPBP, PLA2G7
9plasma membraneGO:0058867.5HMOX2, PTGDR2, PTGS1, TBXA2R, CYSLTR2, CYSLTR1

Biological processes related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 92)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824511.3CCL5, CCL13, CCL24, CCR3, CCL11, SCG2
2immune responseGO:00695511.2C5AR1, CSF2, PRG2, OSM, TGFBR3, TLR4
3chemotaxisGO:00693511.2CCR3, CCL1, CCL17, CCL20, CCR8, CCL11
4positive regulation of tumor necrosis factor productionGO:03276011.1TLR4, TLR3, TLR2, PF4, NOD2, NOD1
5cell-cell signalingGO:00726711.0CCL22, CD86, CCL24, CCL13, CCL5, CALCA
6elevation of cytosolic calcium ion concentrationGO:00720411.0KNG1, C3AR1, C5AR1, CXCR3, TAC1, TACR1
7defense response to bacteriumGO:04274210.9NOD1, NOD2, NOS2, RNASE3, LTF, TLR3
8inflammatory responseGO:00695410.8SCG2, BDKRB2, SELE, RELA, PIK3CG, CCL17
9leukocyte cell-cell adhesionGO:00715910.7SELE, SYK, CALCA, ICAM1, CCL5, APOA4
10positive regulation of interleukin-12 productionGO:03273510.7TLR9, TLR4, TLR3, HLA-G, TLR2, IFNG
11positive regulation of T cell proliferationGO:04210210.7IL4, IFNG, VCAM1, CD28, ITGAL, IL6
12G-protein coupled receptor signaling pathwayGO:00718610.6IL8, CXCR1, CCR8, AGT, EDN1, TBXA2R
13cellular response to lipopolysaccharideGO:07122210.6TLR4, CD14, SERPINE1, GSTP1, LTC4S, NOS2
14cellular calcium ion homeostasisGO:00687410.5CCL11, CCL7, CCL14, CCL1, CCL5, TRPM8
15positive regulation of NF-kappaB import into nucleusGO:04234610.3TNF, IL1B, TLR4, IL12B, TLR2, TLR9
16positive regulation of inflammatory responseGO:05072910.3SERPINE1, IL12B, IL15, IL18, IL23A, IL33
17positive regulation of interleukin-8 productionGO:03275710.3TLR4, TLR9, ADIPOQ, TLR2, TLR3, IL1B
18positive regulation of interferon-gamma productionGO:03272910.2TLR4, TNF, IL23A, IL1B, IL18, IL12RB2
19positive regulation of NF-kappaB transcription factor activityGO:05109210.2ICAM1, TNF, TNFRSF8, NOD1, NOD2, NLRP3
20interferon-gamma-mediated signaling pathwayGO:06033310.2HLA-G, HLA-DRB4, STAT1, HLA-DRB1, HLA-DQA1, HLA-C
21defense response to Gram-negative bacteriumGO:05082910.1S100A7, SERPINE1, CD4, IL12B, TLR4, NOS2
22positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.1IL6, AGT, VEGFA, SYK, OSM, ADIPOQ
23defense response to virusGO:05160710.1CD40, CD86, RELA, TLR3, NLRP3, F2RL1
24positive regulation of interleukin-6 productionGO:03275510.1IL1A, IL33, IL6, TLR4, TNF, NOD1
25positive regulation of vasoconstrictionGO:04590710.0TACR1, CYSLTR1, TBXA2R, PTGS1, PTGS2, ALOX5
26lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL18, IL1B, TGFB1, TLR4, TLR2, STAT1
27response to glucocorticoid stimulusGO:0513849.8ADIPOQ, NGF, PTGDS, PTGS2, IL1RN, IL10
28cytokine-mediated signaling pathwayGO:0192219.8VCAM1, HLA-DRB4, HLA-G, PF4, EGR1, STAT1
29neutrophil chemotaxisGO:0305939.8C5AR1, EDN1, SPP1, PIK3CG, IL1B, PRKCA
30Toll signaling pathwayGO:0080639.4JUN, BTK, CD14, IRAK4, NFKB1, RELA
31toll-like receptor 4 signaling pathwayGO:0341429.4NOD2, NFKB1, RELA, BTK, JUN, CD14
32positive regulation of cell proliferationGO:0082849.3CSF2, IL15, EDN1, NGF, CCL14, IL9
33cell surface receptor signaling pathwayGO:0071669.3IL12RB2, IL1R1, IL2RA, MAPK14, IFNG, TRPV1
34signal transductionGO:0071659.2CCL8, PDE4A, KITLG, VIPR2, MAPK1, MAPK14
35response to ethanolGO:0454719.2TH, IL13, IL4, ICAM1, TLR4, TACR1
36anti-apoptosisGO:0069169.2AKT1, HMOX1, MPO, RELA, BDNF, BCL2
37toll-like receptor signaling pathwayGO:0022249.2RELA, JUN, CD86, BTK, TLR4, TLR2
38positive regulation of nitric oxide biosynthetic processGO:0454299.2IL1B, IFNG, HRH1, TNF, PTGS2, EGFR
39agingGO:0075689.0IL15, JUN, VCAM1, CALCA, CCL5, IL1B
40positive regulation of angiogenesisGO:0457668.9CCL5, CCL24, CCR3, CCL11, IL1B, IL1A
41response to drugGO:0424938.8TBXA2R, ABP1, TGFB1, TGFBR2, SOD1, GATA3
42positive regulation of smooth muscle cell proliferationGO:0486618.8STAT1, IL13, TNF, JUN, IRAK4, PTGS2
43response to heatGO:0094088.8MMP9, IL1B, CALCA, AKT1, NOS1, TACR1
44response to lipopolysaccharideGO:0324968.8EDN1, JUN, MMP9, IL12A, IL13, IL1A
45positive regulation of transcription from RNA polymerase II promoterGO:0459448.7NTF3, RELA, IL33, IL4, IL6, MAPK14
46innate immune responseGO:0450878.6SYK, PIK3CG, RELA, SFTPD, BTK, BPIFA1
47negative regulation of apoptotic processGO:0430668.2CSF2, EGFR, PF4, TNF, AKT1, ALB
48response to hypoxiaGO:0016668.1IL1B, EDN1, NOS2, TGFBR3, VCAM1, TLR4
49platelet activationGO:0301688.1VEGFA, SERPINE1, CD40, PIK3CG, TF, SYK
50blood coagulationGO:0075967.6SOD1, SERPINE1, ITGAL, VEGFA, PIK3CG, MAPK14

Molecular functions related to allergic rhinitis according to GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800911.5PF4, CCL7, CCL8, IL8, CCL26, CCL22
2cytokine receptor activityGO:00489610.6IL17RB, IL13RA2, IL12RB2, IL12RB1, IL12B, IL28RA
3heparin bindingGO:00820110.1ABP1, ELANE, TGFBR3, PRG2, KNG1, LTF
4growth factor activityGO:0080839.9IL9, NTF3, PPBP, NGF, AGT, TYMP
5cytokine activityGO:0051259.7ADIPOQ, CSF2, OSM, TSLP, EDN1, SPP1
6transmembrane signaling receptor activityGO:0048889.4EGFR, TLR2, TLR3, TLR4, SLAMF1, NGFR
7protein homodimerization activityGO:0428038.1NR3C1, NOD1, NOS2, NFKB1, ABP1, TGFB1
8protein bindingGO:0055154.7NOD1, NOD2, NOS1, NOS2, NLRP3, NGFR

Sources for Allergic Rhinitis

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS