MCID: ALL003
MIFTS: 68

Allergic Rhinitis

Categories: Genetic diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Allergic Rhinitis

MalaCards integrated aliases for Allergic Rhinitis:

Name: Allergic Rhinitis 53 12 71 36 28 51 14 69
Hay Fever 12 40 69 59
Allergic Rhinitis, Susceptibility to 53 13
Rhinitis, Allergic, Perennial 41 69
Atopic Rhinitis 12 69
Alrh 53 71
Non-Seasonal Allergic Rhinitis 12
Rhinitis, Allergic, Seasonal 41
Perenial Allergic Rhinitis 12
Seasonal Allergic Rhinitis 12
Rhinitis Allergic Seasonal 51
Pollenosis 12

Classifications:



External Ids:

OMIM 53 607154
Disease Ontology 12 DOID:4481
NCIt 46 C34987
SNOMED-CT 64 38103000
MedGen 39 C2607914
KEGG 36 H01360
ICD10 32 J30.1

Summaries for Allergic Rhinitis

MedlinePlus : 40 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. Some of the pollen ends up in your nose and throat. This can trigger a type of allergy called hay fever. Symptoms can include Sneezing, often with a runny or clogged nose Coughing and postnasal drip Itching eyes, nose and throat Red and watery eyes Dark circles under the eyes Your health care provider may diagnose hay fever based on a physical exam and your symptoms. Sometimes skin or blood tests are used. Taking medicines and using nasal sprays can relieve symptoms. You can also rinse out your nose, but be sure to use distilled or sterilized water with saline. Allergy shots can help make you less sensitive to pollen and provide long-term relief. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Allergic Rhinitis, also known as hay fever, is related to pollen allergy and ige responsiveness, atopic, and has symptoms including rhinorrhea, equilibration disorder and vertigo/dizziness. An important gene associated with Allergic Rhinitis is IL13 (Interleukin 13), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Allegra and Allegra-D have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin, and related phenotypes are hematopoietic system and digestive/alimentary

UniProtKB/Swiss-Prot : 71 Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.

Disease Ontology : 12 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

PubMed Health : 59
About hay fever: Many children and adults are affected by hay fever in the spring and summer months, when plants grow and bloom. Sneezing and itchy eyes can be a real problem, especially on days that are warm and dry. A lot of people who have allergies and asthma have more asthma attacks around this time of year too.Hay fever is an allergic reaction to pollen in the air, affecting the upper airways. The symptoms it causes are called allergic rhinitis.

Wikipedia : 72 Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose which occurs when the... more...

Description from OMIM: 607154

Related Diseases for Allergic Rhinitis

Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 pollen allergy 32.4 EPX ICAM1 IL13 IL4R IL5 RNASE3
2 ige responsiveness, atopic 31.1 HAVCR1 IGES IGHE IL13 IL4 IL4R
3 sinusitis 31.0 CXCL8 IL4R IL5 RNASE3
4 urticaria 30.8 HRH1 MS4A2 RNASE3
5 otitis media 30.5 CCL11 CXCL8 IGHE IL4 RNASE3
6 allergic bronchopulmonary aspergillosis 30.5 EPX IL4 IL5
7 blepharoconjunctivitis 30.4 CCL11 IL4 RNASE3
8 cough variant asthma 30.2 IL4 IL5 NGF RNASE3
9 common cold 30.2 CCL11 CXCL8 ICAM1 IL13 IL5 RNASE3
10 dermatitis 30.1 CCL11 IGES IGHE IL13 IL4 IL5
11 bronchitis 30.0 CCL11 CXCL8 IL5 MPO RNASE3
12 allergic conjunctivitis 29.9 CCL11 CXCL8 HRH1 ICAM1 IL13 IL4
13 food allergy 29.8 EPX IL13 IL4 IL5 MS4A2 RNASE3
14 vernal keratoconjunctivitis 29.8 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
15 conjunctivitis 29.5 CCL11 CXCL8 HRH1 ICAM1 IL13 IL4
16 allergic asthma 29.4 CCL11 CXCL8 EPX IGHE IL13 IL4
17 rhinitis 29.4 CCL11 CXCL8 EPX FOXJ1 HAVCR1 HRH1
18 keratoconjunctivitis 29.2 CCL11 CXCL8 ICAM1 IL13 IL4 IL5
19 allergic hypersensitivity disease 29.2 CCL11 EPX HRH1 IGES IGHE IL13
20 dermatitis, atopic 28.1 CCL11 CXCL8 EPX HRH1 ICAM1 IGHE
21 asthma 26.6 ALOX5 CCL11 CXCL8 EPX HAVCR1 HRH1
22 asthma-related traits 4 12.0
23 vasomotor rhinitis 10.8
24 cytokine deficiency 10.6 IL13 IL5
25 loeffler endocarditis 10.6 IL5 RNASE3
26 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL13 IL5
27 pemphigoid gestationis 10.6 CCL11 IL5
28 eosinophilic granuloma 10.6 EPX RNASE3
29 paragonimiasis 10.6 IL13 IL5 RNASE3
30 strongyloidiasis 10.5 CCL11 IL13 IL5
31 beta-lactam allergy 10.5 IL13 IL4 IL4R
32 prurigo nodularis 10.5 NGF RNASE3
33 radiculopathy 10.5 CCL11 IL13 IL5
34 mercury poisoning 10.5 IL13 IL18
35 apple allergy 10.5 IL13 IL4 IL5
36 intestinal schistosomiasis 10.5 IL13 IL4 IL5
37 bagassosis 10.5 CXCL8 IL5
38 chronic tic disorder 10.5 IL13 IL4 IL5
39 hyper ige syndrome 10.5 IGHE IL4 IL4R
40 intrinsic asthma 10.5 IL4 IL5 RNASE3
41 enterobiasis 10.5 IL13 IL4 IL5
42 egg allergy 10.5 IGHE IL4 IL5
43 toxicodendron dermatitis 10.5 CXCL8 ICAM1
44 conjunctival nevus 10.5 EPX NGF RNASE3
45 folliculitis 10.5 CCL11 IL4 IL5
46 toxic oil syndrome 10.5 IGHE IL4 IL5
47 milk allergy 10.5 IL4 IL5 RNASE3
48 cutaneous leishmaniasis 10.5 IL13 IL4 IL5
49 status asthmaticus 10.5 CXCL8 IL5 RNASE3
50 papillary conjunctivitis 10.5 CCL11 CXCL8 IL4

Comorbidity relations with Allergic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Hypertension, Essential
Hypothyroidism

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to Allergic Rhinitis

Symptoms & Phenotypes for Allergic Rhinitis

Clinical features from OMIM:

607154

UMLS symptoms related to Allergic Rhinitis:


rhinorrhea, equilibration disorder, vertigo/dizziness, sore throat, tinnitus, snoring, coughing

MGI Mouse Phenotypes related to Allergic Rhinitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 IL4 IL4R IL5 MPO ALOX5 MS4A2
2 digestive/alimentary MP:0005381 9.7 IL18 IL4 IL4R IL5 FOXJ1 ICAM1
3 immune system MP:0005387 9.4 IL18 IL4 IL4R IL5 MPO ALOX5

Drugs & Therapeutics for Allergic Rhinitis

PubMedHealth treatment related to Allergic Rhinitis: 59

Various medications are available to treat the symptoms:AntihistaminesSteroids (corticosteroids)Chromones (mast cell stabilizers)Leukotriene receptor antagonistsDecongestant nasal drops and spraysThere are also non-drug alternatives such as saline (salt water) nasal sprays and nasal washes (nasal irrigation).Allergen-specific immunotherapy (also known as desensitization) can reduce your sensitivity to allergens over the long term. Like with vaccines, this treatment approach involves being exposed to small amounts of the substance by having it injected or placing it under your tongue. In allergen-specific immunotherapy, you are exposed to the allergen at regular intervals. The treatment takes about three years to complete.

FDA approved drugs:

(show all 19)
# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Allegra 17 FEXOFENADINE HYDROCHLORIDE Hoechst Marion Roussel July 1996
2
Allegra-D 17 FEXOFENADINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE Hoechst Marion Roussel March 1998
3
Astelin nasal spray 17 AZELASTINE HYDROCHLORIDE Wallace Laboratories November 1996
4
Atrovent 17 IPRATROPIUM BROMIDE Boehringer Ingelheim January 1996
5
Clarinex 17 DESLORATADINE Schering-Plough February 2002
6
Claritin RediTabs 17 LORATADINE Schering-Plough January 1997
7
Clemastine fumarate syrup 17 CLEMASTINE FUMARATE Morton Grove Pharmaceuticals March 1998
8
Dymista 17 AZELASTINE HYDROCHLORIDE; FLUTICASONE PROPIONATE Meda Pharmaceuticals Inc May 2012
9
Flonase Nasal Spray 17 FLUTICASONE PROPIONATE GlaxoSmithKline November 1997
10
Grastek 17 Timothy Grass Pollen Allergen Extract Merck April 2014
11
Nasacort AQ Nasal Spray 17 TRIAMCINOLONE ACETONIDE Phone-Poulenc Rorer October 1997
12
Oralair 17 Greer Labs April 2014
13
Patanase 17 OLOPATADINE HYDROCHLORIDE Alcon April 2008
14
Qnasl 17 BECLOMETHASONE DIPROPIONATE Teva Pharmaceutical March 2012
15
Ragwitek 17 Merck April 2014
16
Rhinocort Aqua Nasal Spray 17 BUDESONIDE AstraZeneca October 1999
17
Tri-Nasal Spray 17 Muro Pharmaceutical February 2000
18
Xyzal 17 LEVOCETIRIZINE DIHYDROCHLORIDE UCB May 2007
19
Zyrtec 17 CETIRIZINE HYDROCHLORIDE Pfizer December 1995

Drugs for Allergic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 304)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-45-6, 75614-87-8 774
2
Capsaicin Approved Phase 4 404-86-4 1548943
3
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 83881-51-0 2678
4
Montelukast Approved Phase 4,Phase 3,Phase 2,Phase 1 158966-92-8 5281040
5
Nitric Oxide Approved Phase 4 10102-43-9 145068
6
Azelastine Approved Phase 4,Phase 3,Phase 2,Phase 1 58581-89-8 2267
7
Levocetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 130018-77-8
8
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
11
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
12
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
13
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2 100643-71-8 124087
14
Loratadine Approved, Investigational Phase 4,Phase 3,Phase 2 79794-75-5 3957
15
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1491-59-4 4636
16
Phenylephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 59-42-7 6041
17
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
18
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 242138-07-4
19
Ciclesonide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 126544-47-6, 141845-82-1 444033
20
Fexofenadine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83799-24-0 3348
21
Adenosine Approved, Investigational Phase 4,Phase 2,Phase 1 58-61-7 60961
22
Budesonide Approved Phase 4,Phase 3,Phase 2 51333-22-3 5281004 63006
23
Doxazosin Approved Phase 4 74191-85-8 3157
24
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
25
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 1 51-43-4 5816
26 Racepinephrine Approved Phase 4,Phase 3,Phase 1 329-65-7
27
Diphenhydramine Approved, Investigational Phase 4,Phase 1 58-73-1, 147-24-0 3100
28
Promethazine Approved, Investigational Phase 4,Phase 1 60-87-7 4927
29
Tranilast Approved, Investigational Phase 4 53902-12-8 93543
30
Prazosin Approved Phase 4 19216-56-9 4893
31
Theophylline Approved Phase 4,Phase 2 58-55-9 2153
32
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
33
Resveratrol Approved, Experimental, Investigational Phase 4,Phase 3 501-36-0 445154
34
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 17753757 6447131
35
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
36
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 10883523 5280795 6221
37
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
38
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
39 Histamine Antagonists Phase 4,Phase 3,Phase 2,Phase 1
40 Histamine H1 Antagonists Phase 4,Phase 3,Phase 2,Phase 1
41
Histamine Phosphate Phase 4,Phase 3,Phase 2,Phase 1 51-74-1 65513
42 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Antipruritics Phase 4,Phase 3,Phase 2,Phase 1
44 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Anti-Allergic Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Histamine H1 Antagonists, Non-Sedating Phase 4,Phase 3,Phase 2,Phase 1
49 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
50 Hormones Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 860)

# Name Status NCT ID Phase Drugs
1 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
2 Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites Unknown status NCT01052610 Phase 4 sublingual house dust mites allergen extract;placebo in sublingual applicator
3 Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4 Sinol or Sinol-M nasal spray
4 Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis Unknown status NCT00488176 Phase 4 montelukast;cetirizine;montelukast and cetirizine;placebo
5 Efficacy of Allergen Immunotherapy for Allergic Rhinitis in Thais Unknown status NCT01115595 Phase 4
6 AZELASTINE/FLUTICASONE (AZE/FLU) Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR) Unknown status NCT02238353 Phase 4 azelastine + fluticasone;Placebo
7 Cosalin® Monotherapy Versus Cosalin® and Xarlin® Combination Therapy Unknown status NCT01062139 Phase 4 Xarlin (Levocetirizine);Cosalin (Petasites hybridus CO2 extract)
8 4"S" - Seasonal Symptoms Suppression Study Unknown status NCT02557269 Phase 4 Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
9 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status NCT02288156 Phase 4 Capsaicin;placebo
10 Anti-inflammatory H1 Antihistamines Allergic Rhinitis Completed NCT02507635 Phase 4 Levocetirizine;Desloratadine
11 Sunovion Growth Study Pediatric Subjects With Mild Asthma & Allergic Rhinitis Completed NCT01550471 Phase 4 Alvesco/Omnaris, QVAR/Beconase, Placebo/Placebo;Alvesco/Omnaris, Placebo/Placebo, QVAR/Beconase;QVAR/Beconase, Alvesco/Omnaris, Placebo/Placebo;QVAR/Beconase, Placebo/Placebo, Alvesco/Omnaris;Placebo/Placebo, Alvesco/Omnaris, QVAR/Beconase;Placebo/Placebo, QVAR/Beconase, Alvesco/Omnaris
12 Quality of Life in Patients With Allergic Rhinitis: Clinical Trial With Bilastine or Loratadine Completed NCT02513290 Phase 4 Bilastine;Loratadine
13 Comparison of Effectiveness and Safety of Sublingual Immunotherapy in Children With Allergic Rhinitis Completed NCT00698594 Phase 4
14 Montelukast and Fexofenadine Versus Montelukast and Levocetrizine Combination in Allergic Rhinitis Completed NCT02551536 Phase 4 Montelukast;Fexofenadine;Levocetrizine
15 Efficacy and Safety of Lectranal® in Treatment of Seasonal Allergic Rhinitis Symptoms Completed NCT00460538 Phase 4
16 Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial Completed NCT00691665 Phase 4 Olopatadine HCL Nasal Spray, 0.6%;Fluticasone Propionate Nasal Spray, 50 mcg
17 Levocetirizine 5 mg: Reduction of Symptoms, Airway Resistance and Sleep Impairment in Persistent Allergic Rhinitis Completed NCT00355771 Phase 4 Levocetirizine;Placebo
18 Montelukast in Mild Asthmatic Children With Allergic Rhinitis (0476-367) Completed NCT00442559 Phase 4 montelukast sodium;inhaled corticosteroid
19 To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis Completed NCT00679250 Phase 4 levocetirizine;placebo to levocetirizine
20 POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis) Completed NCT00160537 Phase 4 Levocetirizine
21 Comparison of the Effects of Nasal Steroids and Montelukast on Olfactory Functions in Patients With Allergic Rhinitis Completed NCT02565212 Phase 4 Montelukast,mometazon froat
22 Fluticasone and Salmeterol in Allergic Rhinitis Completed NCT01388595 Phase 4 FLUTICASONE PROPRIONATE;Salmeterol;PLACEBO
23 Nasal Budesonide Efficacy on Nasal FeNO in Children With Allergic Rhinitis Completed NCT02409563 Phase 4 Budesonide nasal spray (100 mcg bid);Budesonide nasal spray (50 mcg bid
24 Alpha-Blockers in Allergic Rhinitis (MAN 01) Completed NCT01946035 Phase 4 Doxazosin XL
25 Children, Perennial Allergic Rhinitis (PAR), l-t Growth Completed NCT00641212 Phase 4 Budesonide;Placebo
26 Efficacy and Tolerability of a Topical Microemulsion in Patients With Allergic Rhinitis Due to Sensitization to Pollen Completed NCT01478425 Phase 4
27 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed NCT00653224 Phase 4 levocetirizine dihydrochloride;placebo
28 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed NCT00621959 Phase 4 levocetirizine dihydrochloride;placebo
29 Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis Completed NCT01326247 Phase 4
30 Safety of PATANASE Nasal Spray in Patients With Perennial Allergic Rhinitis Completed NCT00789555 Phase 4 Olopatadine hydrochloride 0.6% nasal spray (PATANASE)
31 Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis Completed NCT00894231 Phase 4 levocetirizine (Xyzal);placebo
32 Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Uni Completed NCT00637611 Phase 4 Fexofenadine HCl
33 Effects of Long-Term Treatment With Nasally Inhaled Triamcinolone Acetonide in Children With Allergic Rhinitis Completed NCT00189449 Phase 4
34 Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With AR. RinASol- Pilot Study Completed NCT02729012 Phase 4 hypertonic saline solution (NACL 3%+NAHCO3)
35 Allergic Rhinitis Changes the Sinus Microbiome Completed NCT01852513 Phase 4 QNASL;Placebo nasal spray
36 Nebulized Beclometasone Dipropionate Improves Nasal Patency in Children With Allergic Rhinitis Completed NCT02646904 Phase 4 Nasal Beclomethasone Dipropionate;CERCHIO 10 mg/ml OS
37 A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis Completed NCT00561717 Phase 4 Azelastine and placebo;Loratadine and Placebo;Cetirizine and Placebo;Placebo and Placebo (spray and Tablet)
38 Study of Bronchodilation Effects of Cetirizine Completed NCT01781507 Phase 4 Cetirizine;Placebo
39 Efficacy & Safety of Loratadine-Betamethasone Oral Solution for Treatment of Severe Perennial Allergic Rhinitis in Children (Study P03428) Completed NCT00963573 Phase 4 Loratadine;Betamethasone
40 A Clinical Study To Test A Nasal Spray (Fluticasone Furoate Nasal Spray) For The Treatment Of Perennial (Year-round) Allergic Rhinitis Completed NCT00609674 Phase 4 Fluticasone furoate nasal spray;Placebo
41 Onset of Effect of Mometasone Nasal Spray in Induced Allergic Rhinitis (Study P03431) Completed NCT00783237 Phase 4 Mometasone;Placebo
42 Assessment of Intranasal Steroids in Allergic Rhinitis When Used Alone or in Combination With an Oral Antihistamine (Study P03270) Completed NCT00834119 Phase 4 Mometasone furoate;Mometasone furoate
43 A 6 Month Safety Study Of Ciclesonide Nasal Aerosol (Zetonna®) And Ciclesonide Nasal Spray (Omnaris®) In Subjects 12 Years And Older With Perennial Allergic Rhinitis (PAR) Completed NCT01654536 Phase 4 ciclesonide nasal aerosol;ciclesonide nasal spray
44 Fluticasone Furoate Treatment of Daytime Somnolence and Cognitive Performance in Seasonal Allergic Rhinitis Completed NCT00997620 Phase 4 Fluticasone furoate Nasal Spray;Placebo
45 Efficacy and Safety of Desloratadine vs. Fexofenadine 180 mg. vs. Placebo for Treating Seasonal Allergic Rhinitis (SAR) (Study P04054) Completed NCT00783146 Phase 4 desloratadine;fexofenadine;placebo
46 Efficacy and Safety of Desloratadine vs. Fexofenadine 180 mg. vs. Placebo for Treating Seasonal Allergic Rhinitis (SAR)(Study P04053)(COMPLETED) Completed NCT00783211 Phase 4 desloratadine;fexofenadine;placebo
47 Comparison of the Effects of Desloratadine and Placebo in the Relief of Nasal Symptom Scores in Subjects With Seasonal Allergic Rhinitis to Cypress Pollen (Study P02836) Completed NCT00867191 Phase 4 Placebo;Desloratadine
48 Study of Triamcinolone Acetonide on the Growth Velocity of Children, Ages 3 to 9, With Perennial Allergic Rhinitis (PAR) Completed NCT00449072 Phase 4 TAA-AQ, Nasacort® AQ;Claritin®
49 Effects of Bilastine on F1 Simulator Driving Performance in Patients Affected by Allergic Rhinitis and/or Urticaria Completed NCT02576041 Phase 4 Bilastine;Placebo
50 Mometasone Furoate on Sleep Disturbances in Subjects With Seasonal Allergic Rhinitis (Study P04608) (COMPLETED) Completed NCT00358527 Phase 4 Mometasone Furoate Nasal Spray (MFNS)

Search NIH Clinical Center for Allergic Rhinitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: rhinitis, allergic, seasonal

Genetic Tests for Allergic Rhinitis

Genetic tests related to Allergic Rhinitis:

# Genetic test Affiliating Genes
1 Allergic Rhinitis 28 IL13

Anatomical Context for Allergic Rhinitis

MalaCards organs/tissues related to Allergic Rhinitis:

38
Eye, Testes, Skin, T Cells, Pituitary, Neutrophil, Brain

Publications for Allergic Rhinitis

Articles related to Allergic Rhinitis:

(show top 50) (show all 1384)
# Title Authors Year
1
Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis. ( 29350019 )
2018
2
Smell loss is associated with severe and uncontrolled disease in children and adolescents with persistent allergic rhinitis. ( 29426750 )
2018
3
Allergic rhinitis management: what's next? ( 29406839 )
2018
4
Impact of acupuncture on antihistamine use in patients suffering seasonal allergic rhinitis: secondary analysis of results from a randomised controlled trial. ( 29440045 )
2018
5
Pattern of allergic rhinitis among children in Ekiti, Nigeria. ( 29447897 )
2018
6
Repeatability of nasal allergen challenge results - further validation of the allergic rhinitis clinical investigator collaborative (AR-CIC) protocols. ( 29432965 )
2018
7
Eating fish and farm life reduce allergic rhinitis at the age of twelve. ( 29446153 )
2018
8
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. ( 29438602 )
2018
9
The use of specific immunoglobulin E in nasal secretions for the diagnosis of allergic rhinitis. ( 29417583 )
2018
10
Radiological comparison of inferior turbinate hypertrophy between allergic and non-allergic rhinitis: does allergy really augment turbinate hypertrophy? ( 29417277 )
2018
11
Correlation between upper and lower airway inflammations in patients with combined allergic rhinitis and asthma syndrome: A comparison of patients initially presenting with allergic rhinitis and those initially presenting with asthma. ( 29434763 )
2018
12
Otolaryngologist adherence to the AAO-HNSF Allergic Rhinitis Clinical Practice Guideline. ( 29412510 )
2018
13
Occupational allergic rhinitis and contact urticaria caused by Gum Arabic in a candy factory worker. ( 29446105 )
2018
14
The International Study of the Allergic Rhinitis Survey: outcomes from 4 geographical regions. ( 29423374 )
2018
15
The control of allergic rhinitis in real life: a multicenter cross-sectional Italian study. ( 29434524 )
2018
16
Changes in basophil activation during immunotherapy with house dust mite and mugwort in patients with allergic rhinitis. ( 29423373 )
2018
17
Benefits of Nasal Cellulose Powder Application Depend on the Type of Allergen Sensitization in Allergic Rhinitis. ( 29411560 )
2018
18
International consensus statement on allergy and rhinology: allergic rhinitis-executive summary. ( 29438600 )
2018
19
Dysbiosis of inferior turbinate microbiota is associated with high total IgE levels in allergic rhinitis patients. ( 29426044 )
2018
20
Reply to the letter to the author concerning: 'Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?' ( 29423746 )
2018
21
Basophils from allergic rhinitis patients show allergen-specific upregulation of thymic stromal lymphopoietin receptor. ( 29413340 )
2018
22
Food allergy and allergic rhinitis in 435 asian patients - A descriptive review. ( 28889132 )
2017
23
Allergen immunotherapy in allergic rhinitis: Current use and future trends. ( 28532268 )
2017
24
Histamine H4 receptor gene polymorphisms: a potential predictor of oral H1 antihistamine efficacy for allergic rhinitis. ( 27888642 )
2017
25
A functional variant of miRNA-149 confers risk for allergic rhinitis and comorbid asthma in Chinese children. ( 28181414 )
2017
26
Non-Allergic Rhinitis: Position paper of the European Academy of Allergology and Clinical Immunology. ( 28474799 )
2017
27
Therapeutic potential of I+-lipoic acid derivative, sodium zinc histidine dithiooctanamide, in a mouse model of allergic rhinitis. ( 28863235 )
2017
28
Recurrent CSF Rhinorrhea Misdiagnosed as Chronic Allergic Rhinitis with Subsequent Development of Bacterial Meningitis. ( 28819362 )
2017
29
Adenoid hypertrophy in children and allergic rhinitis. ( 28887688 )
2017
30
Effects of anticholinergic agent on miRNA profiles and transcriptomes in a murine model of allergic rhinitis. ( 28901404 )
2017
31
Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-I^ in Guinea Pigs. ( 28894978 )
2017
32
Role of Interleukin-17A on the Chemotactic Responses to CCL7 in a Murine Allergic Rhinitis Model. ( 28046055 )
2017
33
Kinetic oscillatory stimulation of nasal mucosa in non-allergic rhinitis: comparison of patient self-administration and caregiver administration regarding pain and treatment effect. A randomized clinical trial. ( 28498078 )
2017
34
Effect of nasal allergen challenge in allergic rhinitis on mitochondrial function of peripheral blood mononuclear cells. ( 28073613 )
2017
35
Could Sublingual Immunotherapy Affect Oral Health in Children with Asthma and/or Allergic Rhinitis Sensitized to House Dust Mite. ( 28950285 )
2017
36
Basophil activation test for inhalant allergens in pediatric patients with allergic rhinitis. ( 28483235 )
2017
37
An intronic single-nucleotide polymorphism (rs13217795) in FOXO3 is associated with asthma and allergic rhinitis: a case-case-control study. ( 29141605 )
2017
38
Management of allergic rhinitis in the era of effective over-the-counter treatments. ( 28532204 )
2017
39
Associations of single nucleotide polymorphisms of PTPN22 and Ctla4 genes with the risk of allergic rhinitis in a Chinese Han population. ( 27888068 )
2017
40
The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study. ( 28906011 )
2017
41
PHENOTYPE OF ALLERGIC RHINITIS AND RHINOSINUSITIS. ( 28515393 )
2017
42
"Allergic mood" - Depressive and anxiety symptoms in patients with seasonal allergic rhinitis (SAR) and their association to inflammatory, endocrine, and allergic markers. ( 28495610 )
2017
43
Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats. ( 28940415 )
2017
44
Validation of the MASK-rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control. ( 28886234 )
2017
45
Mapping and comparing bacterial microbiota in the sinonasal cavity of healthy, allergic rhinitis, and chronic rhinosinusitis subjects. ( 28481057 )
2017
46
The prevalence and associated lifestyle risk factors of self-reported allergic rhinitis in Kazakh population of Fukang City. ( 28953622 )
2017
47
IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite. ( 28912627 )
2017
48
T-helper 2 cytokine-induced heat shock protein 70 secretion and its potential association with allergic rhinitis. ( 28054753 )
2017
49
Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand. ( 28692122 )
2017
50
Allergen immunotherapy for the treatment of allergic rhinitis and/or asthma: an umbrella review. ( 28495938 )
2017

Variations for Allergic Rhinitis

Expression for Allergic Rhinitis

LifeMap Discovery
Genes differentially expressed in tissues of Allergic Rhinitis patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CST1 cystatin SN Respiratory System + 6.00 0.000
Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for Allergic Rhinitis

Pathways related to Allergic Rhinitis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 ALOX5 CCL11 CXCL8 EPX ICAM1 IGHE
2
Show member pathways
13.63 ALOX5 CCL11 CXCL8 IL13 IL18 IL4
3
Show member pathways
13.5 CCL11 CXCL8 ICAM1 IL13 IL18 IL4
4
Show member pathways
13.38 CCL11 CXCL8 IL13 IL18 IL4 IL4R
5
Show member pathways
13.3 ALOX5 CCL11 CXCL8 ICAM1 IGHE IL13
6
Show member pathways
13.26 CCL11 CXCL8 IL13 IL18 IL4 IL4R
7 12.79 CXCL8 IL13 IL4 IL4R IL5
8
Show member pathways
12.75 CXCL8 ICAM1 IL13 IL18 IL4
9
Show member pathways
12.6 IGHE IL18 IL4 IL4R MS4A2
10
Show member pathways
12.56 ALOX5 IGHE IL13 IL4 IL5 MS4A2
11
Show member pathways
12.55 IL13 IL18 IL4 IL4R IL5
12
Show member pathways
12.37 CCL11 HRH1 IGHE IL4 IL4R
13
Show member pathways
12.35 CCL11 CXCL8 EPX ICAM1 IL13 IL4
14
Show member pathways
12.32 IL13 IL4 IL4R IL5
15
Show member pathways
12.3 CCL11 CXCL8 IL13 IL4 IL5
16
Show member pathways
12.29 ALOX5 ICAM1 IL4 MPO
17
Show member pathways
12.12 CXCL8 IL13 IL18 IL4 IL5
18 11.84 IL4 IL4R IL5
19 11.8 CXCL8 ICAM1 IL18
20 11.76 IL13 IL18 IL4 IL5
21 11.74 CXCL8 ICAM1 IL13 IL4 IL5
22
Show member pathways
11.72 CXCL8 IL4 IL5
23 11.65 ICAM1 IL4 IL5
24 11.6 CCL11 IGHE IL4 IL4R IL5
25 11.57 CCL11 CXCL8 IL13 IL4 IL5
26 11.5 CXCL8 ICAM1 IL18
27 11.48 ICAM1 KNG1 MPO
28 11.41 CXCL8 ICAM1 IL13 IL18 IL4
29 11.33 ALOX5 CCL11 CXCL8 ICAM1 IGHE IL13
30 11.32 CCL11 IL13 IL4 IL4R IL5
31 11.3 IL4 IL4R IL5
32 11.28 IL13 IL18 IL4 IL5
33 11.24 IL13 IL4 IL5
34 11.17 IL13 IL4 IL5
35 11.16 CCL11 CXCL8 IL13 IL18 IL4 IL5
36 10.98 CCL11 CXCL8 IL13 IL18 IL4 IL5
37 10.91 IL4 IL4R
38 10.88 ICAM1 MPO
39 10.54 IL13 IL4 IL4R IL5

GO Terms for Allergic Rhinitis

Cellular components related to Allergic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ALOX5 CCL11 CXCL8 EPX IGHE IL13
2 external side of plasma membrane GO:0009897 9.46 ICAM1 IGHE IL13 MS4A2
3 extracellular space GO:0005615 9.44 ALOX5 CCL11 CXCL8 EPX ICAM1 IL13

Biological processes related to Allergic Rhinitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cellular response to interleukin-1 GO:0071347 9.7 CCL11 CXCL8 ICAM1
2 regulation of receptor activity GO:0010469 9.7 CCL11 CXCL8 IL13 IL18 IL4 IL5
3 immune response GO:0006955 9.61 CCL11 CXCL8 IGHE IL13 IL18 IL4
4 regulation of cell adhesion GO:0030155 9.58 CXCL8 ICAM1 IL18
5 positive regulation of macrophage activation GO:0043032 9.55 IL13 IL4R
6 neutrophil activation GO:0042119 9.54 CXCL8 IL18
7 positive regulation of B cell proliferation GO:0030890 9.54 IL13 IL4 IL5
8 positive regulation of mast cell degranulation GO:0043306 9.51 IL13 IL4R
9 eosinophil chemotaxis GO:0048245 9.49 CCL11 HRH1
10 positive regulation of immunoglobulin production GO:0002639 9.48 IL13 IL4R
11 positive regulation of T-helper 2 cell differentiation GO:0045630 9.46 IL18 IL4R
12 type 2 immune response GO:0042092 9.43 IL18 IL4
13 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 ICAM1 IL13 IL4
14 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL13 IL4
15 inflammatory response GO:0006954 9.28 ALOX5 CCL11 CXCL8 HRH1 IL13 IL18

Molecular functions related to Allergic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL11 CXCL8 IL13 IL18 IL4 IL5