Allergic Rhinitis malady

MedlinePlus: Each spring, summer, and fall, trees, weeds and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat dark circles under the eyes taking medicines, using nasal sprays and rinsing out your nose can relieve symptoms. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases²³

MalaCards: Allergic Rhinitis, also known as hay fever, is related to asthma and rhinitis. An important gene associated with Allergic Rhinitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Akt Signaling and RAR-Gamma-RXR-Alpha Degradation. The drugs beclomethasone and brompheniramine and the compounds allergens and methacholine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and small intestine, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology: A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.⁶

Wikipedia: Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as...⁴⁴ more...

OMIM: 607154

Aliases & Descriptions:

allergic rhinitis 6 8 33 32 hay fever 6 23 43 allergic rhinitis due to animal (cat) (dog) hair and dander 6 allergic rhinitis due to pollen (disorder) 6 seasonal allergic rhinitis (disorder) 6 allergic rhinitis due to pollen 6 non-seasonal allergic rhinitis 6 allergic rhinitis due to food 6 rhinitis, allergic, perennial 43 allergic rhinitis (disorder) 43

allergy to pollen (disorder) 6 perenial allergic rhinitis 6 seasonal allergic rhinitis 6 rhinitis allergic seasonal 32 hay fever - pollens 6 hypersensitivity 43 atopic rhinitis 6 pollenosis 6 pollinosis 6 rhinitis 43

Diseases related to allergic rhinitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 969)

id	Related Disease	Score	Top Affiliating Genes
1	asthma	38.9	SCGB1A1, SCGB3A2, IL12B, IL13, CCL11, HNMT
2	rhinitis	36.2	PIP, PIK3CG, PDCL, PDE4A, RELA, RENBP
3	atopic dermatitis	34.9	PDE4A, KITLG, SELE, VIP, VCAM1, BDNF
4	chronic rhinitis	33.9	MPO, CALCA, HRH1, RNASE3, EDN1, EPX
5	eosinophilia	33.7	PDE4A, SFTPA1, SFTPA2, SFTPD, VCAM1, CLC
6	allergic asthma	33.3	SERPINE1, VCAM1, BDNF, BCL2, SCGB1A1, MS4A2
7	eczema	33.0	BTK, SELE, VIP, MS4A2, MPO, CD79A
8	vernal keratoconjunctivitis	31.8	VCAM1, MMP9, IL13, IL3, IL4, IL5
9	extrinsic allergic alveolitis	31.6	SFTPD, CD14, FCER2, IL18, IL1A, IL8
10	allergic conjunctivitis	31.5	IL13, IL4, IL5, CCL11, IGHE, HRH1
11	allergic bronchopulmonary aspergillosis	31.5	SFTPD, IL4, IL5, MBL2, IGES, IGHE
12	bronchial asthma	31.4	KITLG, SFTPD, SELE, VIP, VEGFA, VCAM1
13	vasomotor rhinitis	31.3	VIP, IL10, IL13, IL16, CALCA, TAC1
14	churg-strauss syndrome	31.2	CHIA, MPO, IL10, IL13, IL2RA, IL4
15	urticaria	30.8	KITLG, SELE, VEGFA, VCAM1, MS4A2, CD79A
16	food allergy	30.4	FOXP3, IL13, IL4, IL5, CCL11, IGES
17	t cell deficiency	30.4	BTK, VCAM1, BCL2, CD79A, CD4, FCGR2A
18	atopy	30.3	RELA, KITLG, VEGFA, KDR, SCGB1A1, MS4A2
19	hypersensitivity reaction type iv disease	30.0	SELE, IL4, IGHE, IFNG, ICAM1, TF
20	polycythemia vera	29.9	PIK3CG, KITLG, SERPINE1, MPO, CD79A, IL3
21	keratoconjunctivitis	29.9	RELA, VIPR1, VEGFA, VCAM1, MUC5AC, CD79A
22	otitis media	29.8	SFTPA1, SFTPA2, SERPINE1, VCAM1, MUC1, MUC2
23	was-related disorders	29.7	BDNF, LEP, CHKB, MPO, IL2RA, IL6
24	fibromyalgia	29.7	SERPINE1, BGLAP, BDNF, CHKB, IL10, IL1B
25	aspergillosis	29.7	SFTPA1, SFTPA2, SFTPD, CD79A, CD4, IL10
26	intrinsic asthma	29.6	FCER2, IL3, IL4, IL5, CCL7, CCL5
27	hypersensitivity reaction type ii disease	29.5	PDE4A, VIP, VCAM1, CD28, CD79A, CD86
28	common cold	29.2	CHIA, IL1R1, IL5, IL8, CCL11, ICAM1
29	rheumatoid arthritis	29.0	CD40, IL10, IL1B, IL1RN, IL23A, HLA-DQA1
30	polycythemia	29.0	PIK3CG, KITLG, SERPINE1, VEGFA, MPO, CD79A
31	immunodeficiency	28.9	BTK, VIP, CD28, CD79A, CD4, CD40LG
32	essential thrombocythemia	28.8	SELE, SERPINE1, BGLAP, MPO, IL3, TNF
33	arthritis	28.6	VIP, IL17A, IL1A, IL1B, IL6, IL8
34	arthus reaction	28.6	FCGR1A, ALOX5, HRH1, HMOX1, TNF, ELANE
35	pulmonary function	28.5	LEP, CHIA, MPO, CD14, IL10, IL13
36	angioedema	28.5	BDKRB2, MS4A2, MME, IL5, IL6, IGHE
37	cutaneous t cell lymphoma	28.4	SELE, ITGAL, IL15, IL2RA, IL4, IL5
38	tuberculosis	28.4	IL10, IL12B, IL1B, IL1RN, IL4, MBL2
39	bullous pemphigoid	28.3	CD79A, ITGAL, FLG, FCER2, IL13, IL5
40	irritable bowel syndrome	28.3	VIP, LEP, MPO, CD79A, CD40LG, IL10
41	cough variant asthma	28.3	IL10, IL4, IL5, IGHE, RNASE3, ACE
42	chronic fatigue syndrome	28.2	VIP, CD4, IL10, IL1R1, IL4, IL6
43	graves' disease	28.1	RETN, KITLG, SELE, VCAM1, BGLAP, BCL2
44	mastocytosis	27.9	KITLG, BGLAP, BCL2, MPO, FCER2, IL13
45	omenn syndrome	27.8	IL10, IL1RN, IL4, IL5, IGHE, IFNG
46	breast cancer	27.5	VEGFA, KDR, BCL2, MMP9, GSTP1, IL10
47	blindness	27.2	PIK3CG, PDE4A, SELE, SERPINF1, SERPINE1, VIP
48	systemic lupus erythematosus	27.1	SELE, VIP, VCAM1, BDNF, MPO, CD28
49	sinusitis	26.9	RELA, SFTPD, BTK, SERPINE1, VEGFA, VCAM1
50	erythema multiforme	26.9	CD79A, CCL22, CCL17, CCL1, CCR3, CCL5

Clinical features from OMIM: 607154

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acrivastine, astemizole, azatadine, azatadine maleate, azelastine, azelastine hydrochloride, beclomethasone, beclomethasone dipropionate, bromodiphenhydramine, bromodiphenhydramine hydrochloride, brompheniramine, brompheniramine maleate, budesonide, carbinoxamine, carbinoxamine maleate, cetirizine, cetirizine hydrochloride, chlorcyclizine, chlorcyclizine hydrochloride, chlorothen maleate, chlorpheniramine, chlorpheniramine maleate, chlorpheniramine polistirex, chlorpheniramine tannate, clemastine, clemastine fumarate, cromolyn, cromolyn sodium, cyproheptadine, cyproheptadine hydrochloride, cyproheptadine hydrochloride monohydrate, desloratadine, dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], dexbrompheniramine, dexbrompheniramine maleate, dexchlorpheniramine, dexchlorpheniramine maleate, diphenhydramine, diphenhydramine citrate, diphenhydramine hydrochloride, doxylamine, doxylamine succinate, ephedra, ephedrine, ephedrine hydrochloride, ephedrine sulfate, ephedrine tannate, fexofenadine, fexofenadine hydrochloride, flunisolide, fluticasone, fluticasone furoate, fluticasone propionate, guaifenesin, hyoscyamine, hyoscyamine hydrobromide, hyoscyamine sulfate, ipratropium, ipratropium bromide, loratadine, methapyrilene, methapyrilene hydrochloride, methdilazine, methdilazine hydrochloride, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, mometasone, mometasone furoate, mometasone furoate monohydrate, montelukast, montelukast sodium, naphazoline, naphazoline hydrochloride, oxymetazoline, oxymetazoline hydrochloride, phenindamine, phenindamine tartrate, phenylpropanolamine, phenylpropanolamine hydrochloride, phenyltoloxamine, phenyltoloxamine citrate, phenyltoloxamine dihydrogen citrate, phenyltoloxamine resin complex, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], promethazine, promethazine hydrobromide, promethazine hydrochloride, pseudoephedrine, pseudoephedrine hydrochloride, pseudoephedrine sulfate, pyrilamine, pyrilamine maleate, pyrilamine tannate, triamcinolone, triamcinolone acetonide, triamcinolone acetonide pwdr [va product], triamcinolone diacetate, triamcinolone hexacetonide, trimeprazine, trimeprazine tartrate, tripelennamine, tripelennamine citrate, tripelennamine hydrochloride

MalaCards organs/tissues related to allergic rhinitis:

²²

MGI Mouse Phenotypes related to allergic rhinitis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	12.0	BTK, BDKRB2, BCL2, CD28, CD3D, CD86
2	respiratory system phenotype	MP:0005388	11.4	SFTPD, BDNF, SCGB1A1, LGR5, CD14, FOXJ1
3	endocrine/exocrine gland phenotype	MP:0005379	10.6	VIPR1, BDKRB2, LGR5, CD40LG, AQP5, IFNG
4	renal/urinary system phenotype	MP:0005367	9.8	PDC, RENBP, CLCN3, BDKRB2, BCL2, SCGB1A1
5	normal phenotype	MP:0002873	9.7	RELA, SELE, VIP, VEGFA, BDKRB2, BDNF
6	integument phenotype	MP:0010771	9.6	PIK3CG, RELA, KITLG, BTK, BDNF, BCL2
7	liver/biliary system phenotype	MP:0005370	9.4	RETN, VEGFA, CLCN3, IL12RB2, IL1R1, IL6
8	immune system phenotype	MP:0005387	9.3	PDE4A, BTK, VIPR2, BPIFA1, CLCN3, BDKRB2
9	behavior/neurological phenotype	MP:0005386	9.0	SELE, VIP, VIPR1, VIPR2, CLCN3, BDKRB2
10	nervous system phenotype	MP:0003631	8.8	PDC, PDE4A, RELA, KITLG, SERPINF1, CLCN3
11	no phenotypic analysis	MP:0003012	8.7	VEGFA, VCAM1, BDNF, LGR5, MUC1, T
12	digestive/alimentary phenotype	MP:0005381	8.1	KITLG, BTK, SERPINF1, VIPR1, VEGFA, CLCN3
13	reproductive system phenotype	MP:0005389	7.9	SERPINF1, VIP, VIPR2, VEGFA, CLCN3, BDKRB2
14	mortality/aging	MP:0010768	7.9	RELA, KITLG, SFTPD, BTK, SELE, SERPINE1
15	growth/size phenotype	MP:0005378	7.8	PIK3CG, RELA, KITLG, SFTPD, BTK, SELE
16	adipose tissue phenotype	MP:0005375	7.4	RETN, SERPINE1, VIPR2, CLCN3, BDKRB2, BCL2
17	skeleton phenotype	MP:0005390	6.7	PIK3CG, RELA, KITLG, VEGFA, CLCN3, BDKRB2
18	vision/eye phenotype	MP:0005391	5.9	PDC, RELA, KITLG, SELE, SERPINF1, VEGFA
19	tumorigenesis	MP:0002006	5.5	KITLG, BTK, SERPINE1, BCL2, SCGB1A1, LGR5
20	cellular phenotype	MP:0005384	5.4	PIK3CG, RELA, KITLG, BTK, SELE, VIPR1
21	homeostasis/metabolism phenotype	MP:0005376	5.1	PIK3CG, PDC, RELA, RENBP, RETN, KITLG
22	muscle phenotype	MP:0005369	4.5	PIK3CG, PDC, RELA, VEGFA, KDR, BCL2
23	cardiovascular system phenotype	MP:0005385	4.3	PIK3CG, PDC, PDE4A, RELA, KITLG, SELE

Articles related to allergic rhinitis:

(show top 50)    (show all 511)

id	Title	Authors	Year	Affiliating Genes
1	Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore. (21723144)	Andiappan A.K.... Chew F.T.	2011	BDNF
2	Association pattern of interleukin-1 receptor-associa ted kinase-4 gene polymorphisms with allergic rhinitis in a Han Chinese populat ion. (21738793)	Zhang Y.... Zhang L.	2011	IRAK4
3	Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farin ae and Japanese cedar pollen. (20128182)	Suzuki K.... Izuhara K.	2010	RNASE3
4	The expression of IL-23 in nasal mucosa of allergic rhinitis patients and its significance]. (20873540)	Liu Y.... Cui Y.	2010	IL23A
5	Increased expression of acidic mammalian chitinase an d chitotriosidase in the nasal mucosa of patients with allergic rhinitis. (20422678)	Cho W.S.... Lee S.H.	2010	CHIT1, CHIA
6	Expression and clinical significance of calcium-acti vated chloride channel and mucins in nasal mucosa with allergic rhinitis (20464982)	Wu W.... Wang L.	2010	CLCA1, MUC5AC
7	FcI/RI levels and frequencies of peripheral blood dend ritic cell populations in allergic rhinitis. (20650300)	Lundberg K.... Lindstedt M.	2010	FCGR1A
8	Three-year follow-up study of allergen-induced in vit ro cytokine and signalling lymphocytic activation molecule mRNA responses in pe ripheral blood mononuclear cells of allergic rhinitis patients undergoing speci fic immunotherapy. (19571569)	Nieminen K.... Savolainen J.	2009	IL18, IL4, IFNG
9	Nasal inflammatory mediators and specific IgE product ion after nasal challenge with grass pollen in local allergic rhinitis. (19796796)	RondA^n C.... Blanca M.	2009	IGHE
10	Soluble serum HLA-G and HLA-A, -B, -C molecules in pa tients with seasonal allergic rhinitis exposed to pollens. (19410660)	Ciprandi G.... Puppo F.	2009	HLA-G
11	Expression and significance of SP-A in nasal mucosa of allergic rhinitis and nasal polyp (19894557)	Deng Y.... Xiao B.	2009	SFTPA1
12	Gene expression profiles of nasal polyps associated with allergic rhinitis. (19027509)	Wu J.... Jingping F.	2009	CCL20
13	Relationship between the IL-12B promoter polymorphism and allergic rhinitis, familial asthma, serum total IgE, and eosinophil level in asthma patients. (19274925)	Tug E.... Yuce H.	2009	IL12B, IGHE
14	Therapeutic effect of montelukast, a cysteinyl leukotriene receptor 1 antagonist, on Japanese patients with seasonal allergic rhinitis. (18566548)	Okubo K.... Baba K.	2008	CYSLTR1
15	Immunoglobulin domain and mucin domain-1 in helper T lymphocytes in allergic rhinitis (19159567)	Wu W.K.... Zhao C.Q.	2008	HAVCR1
16	Expression of substance P, vasoactive intestinal peptide and heat shock protein 70 in nasal mucosal smears of patients with allergic rhinitis: investigation using a liquid-based method. (18282334)	Chalastras T.... Athanassiadou P.	2008	HSPA8, VIP
17	The Allergic Rhinitis and its Impact on Asthma system: a new classification of allergic rhinitis and nasal responsiveness. (17498329)	Sheahan P.... Costello R.W.	2008	KNG1
18	Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis (18260253)	Gawlik R.... Jawor B.	2007	EDN1
19	T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non-allergic controls and following allergen immunotherapy. (17156343)	Francis J.N.... Till S.J.	2007	CCR3
20	Relation between IgE levels and infections in patients with allergic rhinitis and asthma (16568707)	Gameros Gardea R.A.... JimAcnez J.	2005	IGHE
21	Correlations between plasma levels of IL-18, IL-4, IFN-gamma, IgE and ECP in the patients with seasonal allergic rhinitis and their clinical implications (15934281)	Lin X.... Xie H.	2005	IL18, IL4, RNASE3
22	Seasonal non-allergic rhinitis (SNAR)--a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis. (16008061)	WedbAock A.... Malcus I.	2005	IGHE
23	Intracellular production of IL-2, IL-4 and IFN-gamma by peripheral blood CD3+ cells in intermittent allergic rhinitis. (15750716)	GlA1ck J.... Mazur B.	2005	IL4, IFNG
24	CD34+ cell and interleukin 5 and eosinophil in the peripheral blood of allergic rhinitis patients (16200968)	Zhang H.... Guo C.	2005	IL5
25	Association between polymorphisms of the angiotensin-converting enzyme and angiotensinogen genes and allergic rhinitis in a Korean population. (15112973)	Kim J.J.... Lee J.H.	2004	ACE, AGT
26	Efficacy, chemistry and pharmacology of chinese herba l medicine for allergic rhinitis. (15180574)	Xue C.C.... Story D.F.	2004	IGHE
27	Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen. (15298558)	Cheng L.... Shirakawa T.	2004	ADAM33
28	Determination of interleukins and IgG4 in patients with allergic rhinitis with and without immunotherapy (15491078)	VelA!zquez B.L.... Feria A.J.	2004	IL4, IFNG, IL5
29	Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma. (15120189)	Gentile D.A.... Skoner D.P.	2004	TGFB1, TNF, IL6
30	Detection of eosinophil cationic protein and E-selectin in serum and nasal lavage fluid in patients with allergic rhinitis (12889102)	Hong S.L.... Sun R.	2003	SELE, RNASE3
31	Decreased serum IgE level, decreased IFN-gamma and IL-5 but increased IL-10 production, and suppressed cyclooxygenase 2 mRNA expression in patients with perennial allergic rhinitis after treatment with a new mixed formula of Chinese herbs. (11407311)	Yang S.H.... Yu C.L.	2001	IL5, IGHE
32	Mucosal output of eotaxin in allergic rhinitis and its attenuation by topical glucocorticosteroid treatment. (11529904)	Greiff L.... Persson C.G.	2001	CCL11
33	Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma. (11251403)	Marcucci F.... Coniglio G.	2001	RNASE3, IGHE
34	As-needed use of fluticasone propionate nasal spray reduces symptoms of seasonal allergic rhinitis. (10756223)	Jen A.... Naclerio R.	2000	RNASE3
35	Nasal soluble levels of ICAM-1 in allergic rhinitis (10739998)	Gilain L.... Caillaud D.	2000	ICAM1
36	Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)	Wright E.D.... Hamid Q.	1999	MAPK1, IL12RB1
37	Serum IFN-gamma and IL-10 levels before and after specific immunotherapy in patients with allergic rhinitis. (10568876)	Keskin G.... Kinikli G.	1999	IFNG, IL10
38	Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis (9585822)	AntAcpara I.... VA!zquez M.	1998	HRH1
39	Ten-year follow-up study of allergen-specific immunoglobulin E and immunoglobulin G4, soluble interleukin-2 receptor, interleukin-4, soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 in serum of patients on immunotherapy for perennial allergic rhinitis. (9496694)	Ohashi Y.... Yamada K.	1998	IL4
40	Effect of mometasone furoate on early and late phase inflammation in patients with seasonal allergic rhinitis. (9860036)	Frieri M.... Nolop K.B.	1998	IL6, IL8, IL5
41	Soluble adhesion molecules and cytokines in perennial allergic rhinitis. (9723565)	Liu C.M.... Cheng Y.K.	1998	SELE, IL5
42	IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis. (9353157)	Till S.... Durham S.	1997	IL5
43	The pharmacological basis for the treatment of perenn ial allergic rhinitis and non-allergic rhinitis with topical corticosteroids. (9212861)	Meltzer E.O.	1997	IL6, NR3C1, IFNG
44	Chemokines in seasonal allergic rhinitis. (8568122)	Kuna P.... Kaplan A.P.	1996	IL8, CCL5, RNASE3
45	Allergen-driven limiting dilution analysis of human IL-4 and IFN-gamma production in allergic rhinitis and clinically tolerant individuals. (8671679)	Li Y.... Hayglass K.T.	1996	IL4, IFNG
46	Effect of six-hour exposure to nitrogen dioxide on early-phase nasal response to allergen challenge in patients with a history of seasonal allergic rhinitis. (7499684)	Wang J.H.... Davies R.J.	1995	MPO, IL8, RNASE3
47	Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture: responses of subjects with allergic rhinitis and normal controls. (7558124)	Imada M.... Hayglass K.T.	1995	IL4, IFNG
48	Allergen-induced changes of B-cell phenotypes in patients with allergic rhinitis. (7535471)	Davidsson A.... Hellquist H.B.	1994	IL4
49	Allergic rhinitis to ragweed pollen. II. Modulation of histamine-releasing factor production by specific immunotherapy. (1370511)	Brunet C.... Hebert J.	1992	TPT1
50	Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators. (1741538)	Sedgwick J.B.... Busse W.W.	1991	IL5

Genes related to allergic rhinitis according to GeneCards:

(show top 50)    (show all 253)

id	Symbol	Description	Score	GeneCards Section Context
1	CCL11	chemokine (C-C motif) ligand 11	11.1	Publications, Summaries
2	NGF	nerve growth factor (beta polypeptide)	11.1	Summaries, Publications
3	IL13	interleukin 13	11.1	Aliases & Descriptions, Publications
4	IL4R	interleukin 4 receptor	11.1	Summaries, Publications
5	FOXJ1	forkhead box J1	11.1	Publications, Summaries
6	ALRH	allergic rhinitis	11.1	Aliases & Descriptions, Publications
7	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
8	IGES	immunoglobulin E concentration, serum	11.0	Publications
9	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
10	CLC	Charcot-Leyden crystal protein	11.0	Publications
11	HRH1	histamine receptor H1	11.0	Publications
12	EPX	eosinophil peroxidase	11.0	Publications, UniProt Related
13	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
14	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
15	CCL24	chemokine (C-C motif) ligand 24	11.0	Publications
16	IL9	interleukin 9	11.0	Publications
17	CCL13	chemokine (C-C motif) ligand 13	11.0	Publications
18	SCG2	secretogranin II	11.0	Publications
19	GATA3	GATA binding protein 3	11.0	Publications
20	HAVCR1	hepatitis A virus cellular receptor 1	11.0	Publications
21	IL4	interleukin 4	11.0	Publications
22	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
23	CCL7	chemokine (C-C motif) ligand 7	11.0	Publications
24	FCER1A	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	11.0	Publications
25	TPT1	tumor protein, translationally-controlled 1	11.0	Publications
26	CCR8	chemokine (C-C motif) receptor 8	11.0	Publications
27	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
28	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
29	HNMT	histamine N-methyltransferase	11.0	Publications
30	HAVCR2	hepatitis A virus cellular receptor 2	11.0
31	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0
32	CCR3	chemokine (C-C motif) receptor 3	11.0	Publications
33	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
34	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
35	TBXA2R	thromboxane A2 receptor	11.0	Publications
36	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
37	IL17A	interleukin 17A	11.0	Publications
38	VIP	vasoactive intestinal peptide	11.0	Publications
39	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
40	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0
41	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
42	TAC1	tachykinin, precursor 1	11.0	Publications
43	IL13RA2	interleukin 13 receptor, alpha 2	11.0
44	TRPV1	transient receptor potential cation channel, subfamily V, member 1	11.0	Publications
45	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
46	ICAM1	intercellular adhesion molecule 1	11.0	Publications
47	KNG1	kininogen 1	11.0	Publications
48	IL16	interleukin 16	11.0	Publications
49	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
50	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications

Pathways related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 196)

id	Pathway	Score	Top Affiliating Genes
1	Akt Signaling36	11.5	PIP, PIK3CG, BTK, CD28, CD4, ITGAL
2	RAR-Gamma-RXR-Alpha Degradation36	11.3	PIP, BTK, IL12A, IL15, IL16, IL23A
3	Chemokine signaling pathway20	11.2	PIK3CG, RELA, ITK, IL8, MAPK1, CCL8
4	Immune System38	11.1	VCAM1, CD79A, CD40, FCGR1A, FCGR3A, IL18
5	Jak-STAT signaling pathway20	11.0	PIK3CG, LEP, IL10, IL12A, IL12B, IL12RB1
6	NFAT Signaling and Lymphocyte Interactions36	10.9	BTK, BCL2, CD3D, CD4, FCER1A, FCER2
7	all-trans-Retinoic Acid Signaling in Brain36	10.7	PIP, BTK, BCL2, IL10, IL12A, IL12B
8	Cytokine production by Th17 cells in CF (Mouse model)41	10.7	RELA, CD14, FOXP3, IL12B, IL12RB1, IL17A
9	STAT3 Pathway36	10.5	PIP, BTK, BCL2, CD28, CD4, IL10
10	SOCS Pathway36	10.5	BTK, BCL2, CD4, IL10, IL12A, IL12B
11	PEDF Induced Signaling36	10.4	PIP, RELA, BTK, SERPINF1, BDNF, BCL2
12	Asthma20	10.3	MS4A2, CD40LG, CD40, FCER1A, IL10, IL13
13	Phagosome20	10.3	SFTPA1, SFTPD, MPO, CD14, FCGR1A, FCGR2A
14	PGC1Alpha Pathway36	10.3	BTK, BCL2, CD4, IL12A, IL12B, IL13
15	Intestinal immune network for IgA production20	10.2	CD28, CD86, CD40LG, CD40, IL10, IL15
16	Cytokine-cytokine receptor interaction20	10.1	KITLG, VEGFA, KDR, LEP, CD40LG, CD40
17	Th1 Differentiation37	10.0	JUN, CD28, CD86, CD4, IL10, IL12A
18	African trypanosomiasis20	9.9	SELE, VCAM1, IL10, IL12A, IL12B, IL18
19	THC Differentiation Pathway36	9.9	CD28, CD86, IL10, IL12A, IL12B, IL12RB1
20	Graft-versus-host disease20	9.9	CD28, CD86, IL1A, HLA-A, HLA-B, HLA-C
21	Measles20	9.9	PIK3CG, RELA, CD28, CD3D, IRAK4, IL12A
22	Chemokine Signaling36	9.9	JUN, IL8, MAPK14, MAPK1, CCL8, CCL7
23	Rho Family GTPases36	9.9	PIP, KITLG, BTK, BDNF, KDR, BCL2
24	Amoebiasis20	9.8	RELA, MUC2, CD14, IL12A, IL12B, IL1B
25	Hematopoietic cell lineage20	9.8	KITLG, CD3D, CD14, CD4, MME, FCER2
26	PAK Pathway36	9.8	PIP, KITLG, BTK, BDNF, KDR, BCL2
27	Th17 Differentiation37	9.7	CD28, CD86, CD4, IL12B, IL12RB1, IL17A
28	Tec Kinases Signaling36	9.6	KITLG, BTK, BDNF, BCL2, CD28, CD3D
29	Autoimmune thyroid disease20	9.6	CD28, CD86, CD40LG, CD40, IL10, IL4
30	Glucocorticoid Receptor Signaling36	9.3	BTK, BCL2, JUN, CD4, IL10, IL12A
31	Immune response MIF-mediated glucocorticoid regulation10	9.2	RELA, VCAM1, JUN, IL6, IL8, MAPK1
32	Immune response_MIF-mediated glucocorticoid regulation41	9.2	RELA, VCAM1, JUN, IL6, IL8, MAPK1
33	ERK Signaling36	9.2	PIP, KITLG, BTK, CD3D, ITGAL, IL10
34	Endothelin-1 Signaling Pathway36	9.2	PIP, BTK, IL10, IL12A, IL12B, IL13
35	Rheumatoid arthritis20	9.0	VEGFA, JUN, CD28, CD86, ITGAL, IL15
36	Type I diabetes mellitus20	9.0	CD28, CD86, IL12A, IL12B, IL1A, IL1B
37	Immune response MIF in innate immunity response10	8.7	RELA, JUN, CD14, IRAK4, IL1B, IL6
38	NF-KappaB (p50-p65) Pathway36	8.7	RELA, KITLG, BDNF, KDR, IRAK4, IL1A
39	Toll-like receptor signaling pathway20	8.7	PIK3CG, RELA, JUN, CD86, CD14, CD40
40	Antioxidant Action of Vitamin-C36	8.6	PIP, KITLG, BTK, BDNF, KDR, BCL2
41	Pertussis20	8.6	RELA, SFTPA1, JUN, CD14, IRAK4, IL10
42	JAK-STAT Pathway36	8.5	KITLG, BTK, BDNF, KDR, BCL2, JUN
43	Osteoclast differentiation20	8.3	PIK3CG, RELA, BTK, JUN, FCGR1A, FCGR2A
44	NF-KappaB Family Pathway36	8.2	RELA, KITLG, BDNF, KDR, IRAK4, IL1A
45	TGF-Beta Pathway36	8.1	KITLG, BTK, BDNF, KDR, BCL2, JUN
46	MAPK Family Pathway36	8.1	KITLG, BTK, BDNF, KDR, BCL2, JUN
47	Leishmaniasis20	7.7	RELA, JUN, IRAK4, FCGR1A, FCGR2A, FCGR3A
48	Influenza A20	7.6	PIK3CG, RELA, JUN, IRAK4, IL12A, IL12B
49	NFAT in Immune Response36	7.5	KITLG, BTK, BDNF, KDR, JUN, CD28
50	Renin-Angiotensin Pathway36	7.1	KITLG, VCAM1, BDNF, KDR, JUN, IL2RA

Compounds related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 479)

id	Compound	Score	Top Affiliating Genes
1	allergens32	11.7	SFTPD, MS4A2, CD79A, CD86, CD14, CD40LG
2	methacholine32 9 9	13.6	VIP, MPO, CD79A, CD14, MME, IL13
3	ltc432	11.4	VIP, IL13, IL3, IL5, CCL11, ALOX5
4	ionomycin32	11.3	BTK, CD40, FCER2, IL12RB1, IL3, IL5
5	thromboxane32 18	12.3	PDE4A, ALOX5, ALOX5AP, HRH1, PTGDR, PTGS1
6	ccl432	11.2	IL12B, IL13, IL15, IL16, IL17A, IL1R1
7	salbutamol32 34 9 18 9	15.2	PDE4A, KITLG, VIP, VCAM1, CHKB, CD79A
8	nadph32 18	11.7	CLCN3, BDKRB2, AKT1, HMOX2, CYP3A4, PRG2
9	peptidoglycan32	10.6	CD14, IL10, IL12B, IL15, IL1B, IL1R1
10	thromboxane a232 18	11.6	PDE4A, BDKRB2, ALOX5, PTGDR, PTGDR2, PTGS2
11	lipid32	10.6	PIK3CG, PDC, PDE4A, RETN, KITLG, SFTPD
12	threonine32	10.4	BTK, BDKRB2, MUC2, MUC5AC, CD4, ITK
13	hyaluronic acid32 18	11.4	SCGB1A1, MUC1, LCN1, ITGAL, IL13, PTGS1
14	mannose32	10.2	SFTPD, CLC, PAPPA, CHIT1, CD79A, CD86
15	ng-nitro-l-arginine32	10.1	PDE4A, VIP, BDKRB2, BDNF, CALCA, NOS1
16	isoproterenol32 9 9	12.1	PDE4A, ITGAL, IL13, IL1A, IL3, IL5
17	endotoxin32	10.0	RETN, SFTPD, SCGB1A1, CHKB, CD86, CD14
18	agar32	9.9	KITLG, MUC1, CD40LG, IL9, AKT1, PTGS1
19	pentoxifylline32 9 9	11.9	PDE4A, VCAM1, MPO, CD14, IL10, IL12B
20	dopamine32 9 18 9	12.7	PDE4A, SELE, VIP, BDNF, SCG2, CHKB
21	aprotinin32 9 9	11.7	VIP, BDKRB2, MMP9, IL1A, IGHE, PPBP
22	clozapine32 34 9 9	12.7	BDNF, LEP, CHKB, MPO, IL10, IL18R1
23	progesterone32 42 9 18 9	13.6	PIP, PDE4A, PAPPA, BCL2, SCGB1A1, MME
24	superoxide32 18	10.6	PDE4A, KITLG, VCAM1, CLCN3, SCG2, CHKB
25	chloroquine32 34 9 9	12.6	CD79A, CD4, ITGAL, IL10, IL15, IL18
26	apocynin32	9.5	SELE, VCAM1, MPO, JUN, ICAM1, DYT10
27	ribavirin32 34 9 9	12.4	VIPR1, LEP, CD40LG, MMP9, IL10, IL18
28	5-hydroxytryptamine32	9.4	BTK, SERPINE1, VIP, SCG2, MME, IL1A
29	ascorbic acid32 18	10.3	PIK3CG, BGLAP, BDNF, CHKB, CD40LG, MME
30	c2ceramide32	9.3	PIK3CG, JUN, IL1B, MAPK14, AKT1, TNF
31	infliximab32 9 9	11.3	SELE, VEGFA, BGLAP, FLG, IL10, IL15
32	sulfasalazine32 9 9	10.8	SELE, MPO, CD79A, CD40LG, IL12B, IL1A
33	simvastatin32 34 42 9 18 9	13.6	KITLG, SELE, SERPINE1, VEGFA, VCAM1, BGLAP
34	estrogen32	8.5	PIP, RETN, SERPINE1, VIP, BGLAP, BDNF
35	wortmannin32 42	9.3	PIK3CG, PDE4A, KITLG, BTK, VCAM1, BDNF
36	n acetylcysteine32	8.2	SELE, VCAM1, BDNF, KDR, MUC5AC, CD79A
37	lactate32	8.2	KITLG, SFTPD, SELE, VIP, VCAM1, BDNF
38	diphenyleneiodonium32	8.2	SERPINF1, VEGFA, VCAM1, MPO, JUN, IL1B
39	cytochalasin d32 42	9.2	PIK3CG, KITLG, SELE, VCAM1, ITGAL, MMP9
40	12-o-tetradecanoylphorbol 13-acetate32	8.1	SCG2, MUC2, CD4, MME, MMP9, FCER2
41	butyrate32	8.1	KITLG, BCL2, LEP, MUC1, MUC2, MPO
42	quercetin32 42 9 18 9	12.0	PIK3CG, SELE, VCAM1, BCL2, JUN, MME
43	creatinine32	7.9	RETN, KITLG, SELE, PAPPA, BDKRB2, BDNF
44	norepinephrine32 9 18 9	10.8	PDC, PDE4A, RETN, KITLG, SELE, VIP
45	mg 13232 42	8.7	PIK3CG, KDR, JUN, IL1A, IL1B, IL8
46	rosiglitazone32 9 18 9	10.5	PIK3CG, RETN, SELE, SERPINE1, VCAM1, LEP
47	tamoxifen32 34 9 9	10.3	PIP, PDE4A, SELE, VEGFA, VCAM1, BGLAP
48	gf 109203x32 42	8.1	PIK3CG, KITLG, BTK, VEGFA, JUN, FLG
49	paraffin32	6.8	PIP, RELA, KITLG, VEGFA, VCAM1, BGLAP
50	genistein32 9 18 9	8.0	PIK3CG, KITLG, BTK, SELE, SERPINE1, VEGFA

Cellular components related to allergic rhinitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	10.5	VIPR1, VIPR2, CLCA1, TGFBR3, TACR1, CXCR2
2	external side of plasma membrane	GO:009897	10.0	CD28, CD79A, CD86, CD4, CD40LG, CD40
3	platelet alpha granule lumen	GO:031093	9.9	TGFB1, TIMP1, PF4, PPBP, ALB, VEGFA
4	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.6	HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
5	cell surface	GO:009986	9.4	NOD2, NGFR, ELANE, TLR2, TLR3, TGFB1
6	ER to Golgi transport vesicle membrane	GO:012507	9.4	HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
7	extracellular space	GO:005615	8.6	WNT2B, KNG1, ADIPOQ, MBL2, CCL14, CCL5
8	extracellular region	GO:005576	8.5	CCL7, PTGDS, SPP1, NTF3, PPBP, PLA2G7
9	plasma membrane	GO:005886	7.5	HMOX2, PTGDR2, PTGS1, TBXA2R, CYSLTR2, CYSLTR1

Biological processes related to allergic rhinitis according to GeneDecks:

(show top 50)    (show all 92)

id	Name	GO ID	Score	Top Affiliating Genes
1	eosinophil chemotaxis	GO:048245	11.3	CCL5, CCL13, CCL24, CCR3, CCL11, SCG2
2	immune response	GO:006955	11.2	C5AR1, CSF2, PRG2, OSM, TGFBR3, TLR4
3	chemotaxis	GO:006935	11.2	CCR3, CCL1, CCL17, CCL20, CCR8, CCL11
4	positive regulation of tumor necrosis factor production	GO:032760	11.1	TLR4, TLR3, TLR2, PF4, NOD2, NOD1
5	cell-cell signaling	GO:007267	11.0	CCL22, CD86, CCL24, CCL13, CCL5, CALCA
6	elevation of cytosolic calcium ion concentration	GO:007204	11.0	KNG1, C3AR1, C5AR1, CXCR3, TAC1, TACR1
7	defense response to bacterium	GO:042742	10.9	NOD1, NOD2, NOS2, RNASE3, LTF, TLR3
8	inflammatory response	GO:006954	10.8	SCG2, BDKRB2, SELE, RELA, PIK3CG, CCL17
9	leukocyte cell-cell adhesion	GO:007159	10.7	SELE, SYK, CALCA, ICAM1, CCL5, APOA4
10	positive regulation of interleukin-12 production	GO:032735	10.7	TLR9, TLR4, TLR3, HLA-G, TLR2, IFNG
11	positive regulation of T cell proliferation	GO:042102	10.7	IL4, IFNG, VCAM1, CD28, ITGAL, IL6
12	G-protein coupled receptor signaling pathway	GO:007186	10.6	IL8, CXCR1, CCR8, AGT, EDN1, TBXA2R
13	cellular response to lipopolysaccharide	GO:071222	10.6	TLR4, CD14, SERPINE1, GSTP1, LTC4S, NOS2
14	cellular calcium ion homeostasis	GO:006874	10.5	CCL11, CCL7, CCL14, CCL1, CCL5, TRPM8
15	positive regulation of NF-kappaB import into nucleus	GO:042346	10.3	TNF, IL1B, TLR4, IL12B, TLR2, TLR9
16	positive regulation of inflammatory response	GO:050729	10.3	SERPINE1, IL12B, IL15, IL18, IL23A, IL33
17	positive regulation of interleukin-8 production	GO:032757	10.3	TLR4, TLR9, ADIPOQ, TLR2, TLR3, IL1B
18	positive regulation of interferon-gamma production	GO:032729	10.2	TLR4, TNF, IL23A, IL1B, IL18, IL12RB2
19	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.2	ICAM1, TNF, TNFRSF8, NOD1, NOD2, NLRP3
20	interferon-gamma-mediated signaling pathway	GO:060333	10.2	HLA-G, HLA-DRB4, STAT1, HLA-DRB1, HLA-DQA1, HLA-C
21	defense response to Gram-negative bacterium	GO:050829	10.1	S100A7, SERPINE1, CD4, IL12B, TLR4, NOS2
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.1	IL6, AGT, VEGFA, SYK, OSM, ADIPOQ
23	defense response to virus	GO:051607	10.1	CD40, CD86, RELA, TLR3, NLRP3, F2RL1
24	positive regulation of interleukin-6 production	GO:032755	10.1	IL1A, IL33, IL6, TLR4, TNF, NOD1
25	positive regulation of vasoconstriction	GO:045907	10.0	TACR1, CYSLTR1, TBXA2R, PTGS1, PTGS2, ALOX5
26	lipopolysaccharide-mediated signaling pathway	GO:031663	9.8	IL18, IL1B, TGFB1, TLR4, TLR2, STAT1
27	response to glucocorticoid stimulus	GO:051384	9.8	ADIPOQ, NGF, PTGDS, PTGS2, IL1RN, IL10
28	cytokine-mediated signaling pathway	GO:019221	9.8	VCAM1, HLA-DRB4, HLA-G, PF4, EGR1, STAT1
29	neutrophil chemotaxis	GO:030593	9.8	C5AR1, EDN1, SPP1, PIK3CG, IL1B, PRKCA
30	Toll signaling pathway	GO:008063	9.4	JUN, BTK, CD14, IRAK4, NFKB1, RELA
31	toll-like receptor 4 signaling pathway	GO:034142	9.4	NOD2, NFKB1, RELA, BTK, JUN, CD14
32	positive regulation of cell proliferation	GO:008284	9.3	CSF2, IL15, EDN1, NGF, CCL14, IL9
33	cell surface receptor signaling pathway	GO:007166	9.3	IL12RB2, IL1R1, IL2RA, MAPK14, IFNG, TRPV1
34	signal transduction	GO:007165	9.2	CCL8, PDE4A, KITLG, VIPR2, MAPK1, MAPK14
35	response to ethanol	GO:045471	9.2	TH, IL13, IL4, ICAM1, TLR4, TACR1
36	anti-apoptosis	GO:006916	9.2	AKT1, HMOX1, MPO, RELA, BDNF, BCL2
37	toll-like receptor signaling pathway	GO:002224	9.2	RELA, JUN, CD86, BTK, TLR4, TLR2
38	positive regulation of nitric oxide biosynthetic process	GO:045429	9.2	IL1B, IFNG, HRH1, TNF, PTGS2, EGFR
39	aging	GO:007568	9.0	IL15, JUN, VCAM1, CALCA, CCL5, IL1B
40	positive regulation of angiogenesis	GO:045766	8.9	CCL5, CCL24, CCR3, CCL11, IL1B, IL1A
41	response to drug	GO:042493	8.8	TBXA2R, ABP1, TGFB1, TGFBR2, SOD1, GATA3
42	positive regulation of smooth muscle cell proliferation	GO:048661	8.8	STAT1, IL13, TNF, JUN, IRAK4, PTGS2
43	response to heat	GO:009408	8.8	MMP9, IL1B, CALCA, AKT1, NOS1, TACR1
44	response to lipopolysaccharide	GO:032496	8.8	EDN1, JUN, MMP9, IL12A, IL13, IL1A
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.7	NTF3, RELA, IL33, IL4, IL6, MAPK14
46	innate immune response	GO:045087	8.6	SYK, PIK3CG, RELA, SFTPD, BTK, BPIFA1
47	negative regulation of apoptotic process	GO:043066	8.2	CSF2, EGFR, PF4, TNF, AKT1, ALB
48	response to hypoxia	GO:001666	8.1	IL1B, EDN1, NOS2, TGFBR3, VCAM1, TLR4
49	platelet activation	GO:030168	8.1	VEGFA, SERPINE1, CD40, PIK3CG, TF, SYK
50	blood coagulation	GO:007596	7.6	SOD1, SERPINE1, ITGAL, VEGFA, PIK3CG, MAPK14

Molecular functions related to allergic rhinitis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	11.5	PF4, CCL7, CCL8, IL8, CCL26, CCL22
2	cytokine receptor activity	GO:004896	10.6	IL17RB, IL13RA2, IL12RB2, IL12RB1, IL12B, IL28RA
3	heparin binding	GO:008201	10.1	ABP1, ELANE, TGFBR3, PRG2, KNG1, LTF
4	growth factor activity	GO:008083	9.9	IL9, NTF3, PPBP, NGF, AGT, TYMP
5	cytokine activity	GO:005125	9.7	ADIPOQ, CSF2, OSM, TSLP, EDN1, SPP1
6	transmembrane signaling receptor activity	GO:004888	9.4	EGFR, TLR2, TLR3, TLR4, SLAMF1, NGFR
7	protein homodimerization activity	GO:042803	8.1	NR3C1, NOD1, NOS2, NFKB1, ABP1, TGFB1
8	protein binding	GO:005515	4.7	NOD1, NOD2, NOS1, NOS2, NLRP3, NGFR