MCID: ALL003
MIFTS: 66

Allergic Rhinitis malady

Respiratory diseases, Immune diseases categories

Summaries for Allergic Rhinitis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat red and watery eyes dark circles under the eyes your health care provider may diagnose hay fever based on a physical exam and your symptoms. sometimes skin or blood tests are used. taking medicines and using nasal sprays can relieve symptoms. you can also rinse out your nose, but be sure to use distilled or sterilized water with saline. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases

MalaCards: Allergic Rhinitis, also known as hay fever, is related to rhinitis and allergic asthma. An important gene associated with Allergic Rhinitis is IL13 (interleukin 13), and among its related pathways are PAK Pathway and Rho Family GTPases. The compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

Wikipedia:63 Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as... more...

Description from OMIM:46 607154

Aliases & Classifications for Allergic Rhinitis

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8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 33MedlinePlus, 9diseasecard, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Aliases & Descriptions:

allergic rhinitis 8 46 10 44 60
hay fever 8 33 60
allergic rhinitis due to animal hair and dander 8
allergic rhinitis, susceptibility to 9
allergic rhinitis due to pollen 8
non-seasonal allergic rhinitis 8
allergic rhinitis due to food 8
seasonal allergic rhinitis 8
perenial allergic rhinitis 8
rhinitis allergic seasonal 44
hay fever - pollens 8
allergy to pollen 8
atopic rhinitis 8
pollenosis 8
pollinosis 8


External Ids:

Disease Ontology8 DOID:4481
NCIt39 C34987
SNOMED-CT56 38103000
OMIM46 607154
ICD1025 J30.1

Related Diseases for Allergic Rhinitis

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17GeneCards, 18GeneDecks
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Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1rhinitis32.4CCL11, SCGB1A1, IGHE, EPX, RNASE3, IL13
2allergic asthma31.7EPX, RNASE3, IL13, IL5, IL9, IL4R
3asthma31.7IL13, SCGB1A1, CCL11
4chronic rhinitis31.2RNASE3, HRH1
5eosinophilia30.9CCL24, CCL11, CCL13, CCR3, IGHE, NGF
6allergic conjunctivitis30.9CCL11, IGHE, RNASE3, IL13, IL5, IL4
7conjunctivitis30.8HRH1, RNASE3, IGHE
8urticaria30.8IGHE, RNASE3, HRH1
9otitis media30.6CCL11, IGHE, RNASE3
10common cold30.5CCL11, RNASE3
11atopic dermatitis30.5CCL11, HRH1, IL4, IL13, RNASE3, NGF
12dermatitis30.5IL5, IL4, IL17A, IL13, IGHE, CCL11
13cystic fibrosis30.3SCGB1A1, RNASE3, CLC, IL9, IL17A
14allergic bronchopulmonary aspergillosis30.3IGHE, IL5, IL4
15giant papillary conjunctivitis30.1CCL11, RNASE3, IL5
16leukemia30.1CCL11, SCGB1A1, NGF, EPX, RNASE3, IL9
17food allergy30.1IL4, IL5, IL13, CCL11, IGHE, EPX
18keratoconjunctivitis30.1CCL11, RNASE3, IL13, IL5
19tuberculosis30.1EPX, IL4R, IL4, IL17A
20graves' disease30.1IL4, IL4R, IL13
21churg-strauss syndrome30.1IL5, RNASE3
22obesity30.1CCL11, IL17A
23allergic urticaria10.6
24vasomotor rhinitis10.5
25neuronitis10.3
26nasopharyngitis10.3
27adenoiditis10.3
28neurodermatitis10.2
29tonsillitis10.2
30aspergillosis10.2
31migraine10.2
32netherton syndrome10.1
33lung cancer10.1
34attention deficit hyperactivity disorder10.1
35pulmonary tuberculosis10.1
36multinodular goiter10.1
37common variable immunodeficiency10.1
38empty sella syndrome10.1
39chronic fatigue syndrome10.1
40klippel-feil syndrome10.1
41cough variant asthma10.1
42osteoporosis10.1
43cervicitis10.1
44goiter10.1
45herpes simplex10.1
46iridocyclitis10.1
47laryngitis10.1
48neonatal jaundice10.1
49sleep disorder10.1
50squamous cell carcinoma10.1

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to allergic rhinitis

Clinical Features for Allergic Rhinitis

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46OMIM
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Clinical features from OMIM:

607154

Drugs & Therapeutics for Allergic Rhinitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Allergic Rhinitis

Drug clinical trials:

Search ClinicalTrials for Allergic Rhinitis

Search NIH Clinical Center for Allergic Rhinitis

Search CenterWatch for Allergic Rhinitis

Genetic Tests for Allergic Rhinitis

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Anatomical Context for Allergic Rhinitis

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32MalaCards
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MalaCards organs/tissues related to Allergic Rhinitis:

32
Skin, Eye, Testes, T cells, Endothelial, B cells, Lung, Bone, Tonsil, Liver, Lymph node, Nk cells, Monocytes, Spleen, Thymus, Heart, Bone marrow

Animal Models for Allergic Rhinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Allergic Rhinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8IGHE, SCGB1A1, HAVCR1, CCR3, CCL11, CCL24
2MP:000539711.6CCL24, CCL11, CCR3, HAVCR1, IGHE, EPX
3MP:000538811.6IL17A, CCL24, CCL11, CCR3, FOXJ1, HAVCR1
4MP:000537611.2CCR3, SCGB1A1, IGHE, NGF, IL13, IL5
5MP:000538111.1IL13, IL5, IL9, IL4R, IL4, IL17A

Publications for Allergic Rhinitis

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50PubMed
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Articles related to Allergic Rhinitis:

(show top 50)    (show all 1181)
idTitleAuthorsYear
1
Effects of airway exposure to di-(2-ethylhexyl) phthalate on allergic rhinitis. (23672524)
2013
2
Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma. (24401902)
2013
3
Non-allergic, mastocytosis-associated rhinitis. (23517036)
2013
4
Pollen-induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity. (24236692)
2013
5
Protocol for a double-blind randomised controlled trial of low dose intradermal grass pollen immunotherapy versus a histamine control on symptoms and medication use in adults with seasonal allergic rhinitis (PollenLITE). (23965180)
2013
6
Adenoidal hypertrophy and allergic rhinitis: is there an inverse relationship? (23406587)
2013
7
Comparative study in the management of allergic rhinitis in children using LED phototherapy and laser acupuncture. (23394792)
2013
8
Allergy immunotherapy: reduced health care costs in adults and children with allergic rhinitis. (23375206)
2013
9
Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model. (23554753)
2012
10
Association of PPAR polymorphisms with cytokine levels in allergic rhinitis. (21785974)
2012
11
Efficacy of mometasone furoate nasal spray for nasal symptoms, quality of life, rhinitis-disturbed sleep, and nasal nitric oxide in patients with perennial allergic rhinitis. (22525384)
2012
12
Quality of life in the Iranian adults with allergic rhinitis. (23264409)
2012
13
Impact of allergic rhinitis on quality of life in patients with bronchial asthma. (23580898)
2012
14
Nasal breathing exercise and its effect on symptoms of allergic rhinitis. (23730580)
2012
15
Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects. (22973903)
2012
16
A comparative study of loratadine syrup and cyproheptadine HCL solution for treating perennial allergic rhinitis in Taiwanese children aged 2-12 years. (22507335)
2012
17
Allergic Rhinitis and Its Impact on Asthma in Asia Pacific and the ARIA Update 2008. (23268481)
2012
18
Role of innate immunity in the pathogenesis of allergic rhinitis. (22569404)
2012
19
Validation of the modified allergic rhinitis and its impact on asthma (ARIA) severity classification in allergic rhinitis children: the PEDRIAL study. (22985483)
2012
20
The CC16 A38G polymorphism is associated with the development of asthma in children with allergic rhinitis. (21255142)
2011
21
Alterations of vasoactive intestinal polypeptide receptors in allergic rhinitis. (21711977)
2011
22
The value and safety of specific nasal provocation in the diagnosis of allergic rhinitis in mild persistent asthma under inhaled steroid therapy. (21038779)
2010
23
Association of ADAM33 gene polymorphisms with adult concomitant allergic rhinitis and asthma in Chinese Han population. (18752037)
2009
24
Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis. (18607915)
2009
25
The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis. (19175892)
2009
26
Evaluation of cytokine mRNA in induced sputum from patients with allergic rhinitis: relationship to airway hyperresponsiveness. (18053010)
2008
27
Secretion of interleukin 4 and immunoglobulin G from peripheral blood mononuclear cells in allergic rhinitis. (18088026)
2007
28
Subjects with non-allergic non-infectious perennial rhinitis do not show nasal hyper-responsiveness to bradykinin. (17043856)
2007
29
Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. (17072057)
2006
30
Correlation of immunoglobulin E, eosinophil cationic protein, and eosinophil count with the severity of childhood perennial allergic rhinitis. (16783451)
2006
31
Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes. (16015268)
2005
32
Expression of T-bet and its relation with IgE and eosinophil cationic protein in patients with allergic rhinitis]. (16874959)
2005
33
Association between HLA class II locus and the susceptibility to Artemisia pollen-induced allergic rhinitis in Chinese population. (14990915)
2004
34
Efficacy, chemistry and pharmacology of chinese herbal medicine for allergic rhinitis. (15180574)
2004
35
The effect of budesonide on the cytokine pattern in patients with perennial allergic rhinitis. (14692430)
2003
36
Airway hyperreactivity in patients with allergic and non-allergic rhinitis]. (12940107)
2003
37
Epithelial cells in nasal fluids from patients with allergic rhinitis: how do they relate to epidermal growth factor, eosinophils and eosinophil cationic protein? (11936914)
2002
38
Decreased serum IgE level, decreased IFN-gamma and IL-5 but increased IL-10 production, and suppressed cyclooxygenase 2 mRNA expression in patients with perennial allergic rhinitis after treatment with a new mixed formula of Chinese herbs. (11407311)
2001
39
Presence and characterization of sensitization to staphylococcal enterotoxins in patients with allergic rhinitis. (11777251)
2001
40
Retrospective study on fluticasone propionate aqueous nasal spray efficacy in patients with allergic rhinitis: evaluation of clinical and laboratory parameters. (11167349)
2001
41
Levels of interleukin-4, interleukin-5, tryptase and eosinophil cationic protein of nasal lavage fluid in pollen allergic rhinitis]. (11019593)
2000
42
Interleukin-5 and interleukin-8 in relation to eosinophils and neutrophils in nasal fluids from school children with seasonal allergic rhinitis. (10565558)
1999
43
Comparison of indoor allergens, allergic scores, and demographic data in Taiwanese adults with asthma or allergic rhinitis, or both. (10462997)
1999
44
Comparison of nasal mucosal responsiveness to neuronal stimulation in non-allergic and allergic rhinitis: effects of capsaicin nasal challenge. (9537786)
1998
45
IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis. (9353157)
1997
46
The pharmacological basis for the treatment of perennial allergic rhinitis and non-allergic rhinitis with topical corticosteroids. (9212861)
1997
47
The influence of 5-lipoxygenase inhibition in allergic rhinitis. (7613199)
1995
48
Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture: responses of subjects with allergic rhinitis and normal controls. (7558124)
1995
49
Nasal disorders in children. Allergic rhinitis, vasomotor rhinitis, and nasal polyps. (3588472)
1987
50
Allergic perennial and non-allergic, vasomotor rhinitis treated with budesonide nasal spray. (6997974)
1980

Genetic Variations for Allergic Rhinitis

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Expression for genes affiliated with Allergic Rhinitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Rhinitis

Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for genes affiliated with Allergic Rhinitis

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51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.3CCL24, IL4, IL4R, IL9, IL5, IL13
2
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11.3CCL24, CCL11, CCL13, CCR3, IL13, IL5
3
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11.3IL4R, IL9, IL5, IL13, CCR3, CCL13
4
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11.2CCL11, EPX, RNASE3, IL13, IL5, IL9
5
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11.2CCL24, CCL11, CCL13, IL13, IL5, IL9
6
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11.2CCL24, CCL11, CCR3, IL13, IL5, IL9
7
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11.0CCL11, IGHE, IL13, IL5, IL4R, IL4
810.9IL4, IL4R, IL9, IL5, IL13
910.9IL13, IL5, IL9, IL4R, IL4
10
Hide members
10.9IL17A, IL4, IL4R, IL5, IL13
1110.9CCL11, IGHE, IL5, IL4R, IL4
1210.8IL13, IL5, IL9, IL4
1310.8IL13, IL5, IL9, IL4
14
Hide members
10.8IL5, IL9, IL4, IL17A
15
Immune response CCR3 signaling in eosinophils
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10.8CCR3, CCL13, CCL11, CCL24
16
Hide members
10.8CCL24, CCL11, CCL13, CCR3
1710.8IL4, IL5, IL13
1810.8CCL11, IL5, IL4
1910.8IL4, IL4R, IL5
2010.8IL5, IL4R, IL4
21
Hide members
10.8IL17A, IL4, IL4R

Compounds for genes affiliated with Allergic Rhinitis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2414.2IL5, CCL24, CCL11, CCL13, CCR3, IGHE
2dexamethasone44 49 28 1115.1CCL11, CCR3, IGHE, NGF, EPX, RNASE3
3tyrosine4411.9IL4R, HAVCR1, NGF, CCR3, CCL11, IL13
4allergens4411.8CCL11, HRH1, RNASE3, IL4, IGHE, EPX
5tarc4411.8IL9, CCL24, CCL11, IL4, IL4R, IL5
6cyclosporin a44 28 5913.8IL13, CCL11, IGHE, NGF, RNASE3, HRH1
7thymidine44 2412.8CCR3, CCL11, IL13, IL5, HRH1, NGF
8actinomycin d4411.7IL4R, NGF, IGHE, CCR3, CCL11, CCL24
9methacholine44 1112.7CCL11, IGHE, IL17A, IL4, IL9, RNASE3
10steroid4411.6IL4R, RNASE3, IL17A, EPX, CCL11, CCL13
11rantes4411.6CCL11, RNASE3, IL9, IL4R, IL4, IL17A
12budesonide44 49 1113.6IL5, IL13, RNASE3, IL4, IGHE, CCL11
13pgd24411.6IGHE, IL5, IL13, RNASE3, CCR3, CCL11
14prednisolone44 28 1113.5RNASE3, EPX, NGF, IGHE, CCL11, IL5
15ionomycin4411.5IL9, IL5, IL13, IL17A, IL4, CCL11
16adenylate4411.5IGHE, HRH1, IL4, IL5, IL13, RNASE3
17sodium cromoglycate4411.5EPX, CCL11, IGHE, HRH1, IL5, RNASE3
18cetirizine44 28 11 2414.5CCL11, HRH1, IL5, RNASE3, EPX, IGHE
19salmeterol44 49 28 1114.5EPX, CCL11, IL4, RNASE3, IL13, IL5
20montelukast44 49 28 1114.5IL4, IL5, IL13, IGHE, CCL11, RNASE3
21ketotifen44 1112.5HRH1, RNASE3, EPX, IGHE, CCL11, IL5
22salbutamol44 49 28 11 2415.4CCL11, IGHE, EPX, RNASE3, IL13, IL5
23fluticasone propionate44 49 59 1114.4CCL11, IGHE, RNASE3, IL13, IL4, IL5
24nedocromil sodium4411.3IL5, HRH1, IL4, RNASE3, IGHE
25praziquantel44 1112.3IL13, IL4, IL5, IGHE, RNASE3
26azelastine44 1112.3IL5, RNASE3, IGHE, HRH1, IL4
27ltd44411.3HRH1, IL5, IL13, RNASE3, CCR3
28ltc44411.3CCL11, EPX, IL5, IL13, RNASE3
29vegf4411.3IL4, IGHE, IL13, IL5, NGF, IL17A
30tacrolimus44 49 1113.2CCL11, IL13, IL17A, IL4, IL5, HRH1
31unicap4411.2IL5, IGHE, CCL11, RNASE3
32omalizumab44 1112.2IL5, IGHE, IL13, IL4
33capsaicin44 2812.2RNASE3, NGF, IGHE, IL5, HRH1
34anti-histamine4411.2CCL11, IGHE, RNASE3, HRH1
35lte44411.2CCL11, IL5, EPX, RNASE3
36aspirin44 49 28 2414.2HRH1, CCL11, IL13, IL4, RNASE3, NGF
37desloratadine44 1112.2IL4, HRH1, IL13, IGHE
38theophylline44 28 11 2414.2IL13, IL5, EPX, RNASE3, NGF
39indomethacin44 59 28 1114.1NGF, IL5, HRH1
40pranlukast44 28 1113.1CCL11, RNASE3, IL5, IL4
41leukotriene b444 59 2413.1IL5, IL13, RNASE3, EPX, CCL11
42sb 20358044 5912.0IL13, IL5, IL4, IL17A, CCL11, NGF
43endotoxin4411.0RNASE3, HRH1, SCGB1A1
44pge24411.0EPX, CCL11
45levocetirizine4410.9CCL11, IL4, HRH1
46ovomucoid4410.9IGHE
47rolipram44 59 2812.9EPX
48creatinine4410.8NGF, RNASE3, IGHE, HRH1, EPX, SCGB1A1
49oxatomide4410.8HRH1, IGHE, IL5
50levocabastine44 28 1112.7RNASE3, IL5, HRH1

GO Terms for genes affiliated with Allergic Rhinitis

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16Gene Ontology
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Cellular components related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.6IL17A, CCL11, CCL13, CCR3, SCGB1A1, NGF

Biological processes related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.7HRH1, CCL24, CCL11, CCL13, CCR3, NGF
2immune responseGO:00695511.7CCL24, CCL11, CCL13, IGHE, IL13, IL5
3eosinophil chemotaxisGO:04824511.2CCL24, CCL11, CCL13, CCR3, HRH1
4chemotaxisGO:00693511.2CCL24, CCL11, CCL13, CCR3, IL4
5signal transductionGO:00716511.1CCL24, CCL11, CCL13, SCGB1A1, IL13, IL4R
6positive regulation of B cell proliferationGO:03089011.0IL4, IL5, IL13
7cell-cell signalingGO:00726711.0CCL24, CCL13, IL13, IL17A
8positive regulation of endothelial cell proliferationGO:00193811.0CCR3, CCL11, CCL24
9response to ozoneGO:01019310.9SCGB1A1, NGF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.9IL4, IL5, NGF
11negative regulation of interleukin-5 productionGO:03271410.9SCGB1A1, EPX
12regulation of proton transportGO:01015510.9IL13, IL4
13mast cell chemotaxisGO:00255110.9CCL11, CCR3
14positive regulation of angiogenesisGO:04576610.8CCR3, CCL11, CCL24
15positive regulation of macrophage activationGO:04303210.8IL13, IL4R
16response to lipopolysaccharideGO:03249610.8IL13, NGF, SCGB1A1
17cytoskeleton organizationGO:00701010.8CCL24, CCL11, CCL13
18regulation of cell shapeGO:00836010.7CCL13, CCL11, CCL24
19defense response to protozoanGO:04283210.4IL4, IL4R

Molecular functions related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.8IL17A, IL4, IL9, IL5, IL13
2chemokine activityGO:00800910.8CCL13, CCL11, CCL24
3growth factor activityGO:00808310.5NGF, IL5, IL9, IL4

Products for genes affiliated with Allergic Rhinitis

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  • Antibodies
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Sources for Allergic Rhinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet