MCID: ALL003
MIFTS: 62

Allergic Rhinitis malady

Respiratory, Immune categories

Summaries for Allergic Rhinitis

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat red and watery eyes dark circles under the eyes your health care provider may diagnose hay fever based on a physical exam and your symptoms. sometimes skin or blood tests are used. taking medicines and using nasal sprays can relieve symptoms. you can also rinse out your nose, but be sure to use distilled or sterilized water with saline. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases

MalaCards: Allergic Rhinitis, also known as hay fever, is related to allergic asthma and asthma. An important gene associated with Allergic Rhinitis is IL13 (interleukin 13), and among its related pathways are PAK Pathway and Rho Family GTPases. The compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lymph node, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

Wikipedia:64 Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as... more...

Description from OMIM:47 607154

Aliases & Classifications for Allergic Rhinitis

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 9diseasecard, 40NCIt, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory, Immune


Aliases & Descriptions:

allergic rhinitis 8 47 10 45 61
hay fever 8 34 61
allergic rhinitis due to animal hair and dander 8
allergic rhinitis, susceptibility to 9
allergic rhinitis due to pollen 8
non-seasonal allergic rhinitis 8
allergic rhinitis due to food 8
seasonal allergic rhinitis 8
perenial allergic rhinitis 8
rhinitis allergic seasonal 45
hay fever - pollens 8
allergy to pollen 8
atopic rhinitis 8
pollenosis 8
pollinosis 8


External Ids:

Disease Ontology8 DOID:4481
NCIt40 C34987
SNOMED-CT57 38103000
OMIM47 607154
ICD1025 J30.1

Related Diseases for Allergic Rhinitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1allergic asthma31.8EPX, RNASE3, IL13, IL5, IL9, IL4R
2asthma31.8IL13, SCGB1A1, CCL11
3chronic rhinitis31.2RNASE3, HRH1
4atopy30.9CCL11, CCR3, HAVCR1, SCGB1A1, IGHE, EPX
5allergic conjunctivitis30.9CCL11, IGHE, RNASE3, IL13, IL5, IL4
6sinusitis30.9CCL11, IGHE, RNASE3, IL5
7urticaria30.9IGHE, RNASE3, HRH1
8common cold30.6CCL11, RNASE3
9atopic dermatitis30.5CCL11, HRH1, IL4, IL13, RNASE3, NGF
10cystic fibrosis30.4SCGB1A1, RNASE3, CLC, IL9, IL17A
11allergic bronchopulmonary aspergillosis30.4IGHE, IL5, IL4
12giant papillary conjunctivitis30.1CCL11, RNASE3, IL5
13vernal keratoconjunctivitis30.1CCL24, CCL11, IGHE, NGF, RNASE3, IL13
14tuberculosis30.1EPX, IL4R, IL4, IL17A
15graves' disease30.1IL4, IL4R, IL13
16churg-strauss syndrome30.1IL5, RNASE3
17allergic urticaria10.6
18vasomotor rhinitis10.5
19neurodermatitis10.3
20n syndrome10.3
21aspergillosis10.3
22lung agenesis10.3
23pulmonary function10.3
24asthma 210.3
25asthma 110.3
26netherton syndrome10.1
27attention deficit hyperactivity disorder10.1
28pulmonary tuberculosis10.1
29multinodular goiter10.1
30common variable immunodeficiency10.1
31empty sella syndrome10.1
32chronic fatigue syndrome10.1
33klippel-feil syndrome10.1
34tonsillitis10.1
35cough variant asthma10.1
36osteoporosis10.1
37sleep disorder10.1
38squamous cell carcinoma10.1
39suppurative otitis media10.1
40allergic angiitis10.1
41cerebrospinal fluid leak10.1
42keratoderma10.1
43autonomic dysfunction10.1
44sleep apnea10.1
45fibromyalgia10.1
46eosinophilia10.0CCL24, CCL11, CCL13, CCR3, IGHE, NGF
47cork-handlers' disease10.0IL17A, CCL11, CCL13, CCR3, SCGB1A1, NGF
48rhinitis10.0CCL11, SCGB1A1, IGHE, EPX, RNASE3, IL13
49leukemia10.0CCL11, SCGB1A1, NGF, EPX, RNASE3, IL9
50multiple sclerosis10.0CCL11, CCR3, SCGB1A1, NGF, IL13, IL5

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to allergic rhinitis

Clinical Features for Allergic Rhinitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

607154

Drugs & Therapeutics for Allergic Rhinitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Allergic Rhinitis

Drug clinical trials:

Search ClinicalTrials for Allergic Rhinitis

Search NIH Clinical Center for Allergic Rhinitis

Search CenterWatch for Allergic Rhinitis

Genetic Tests for Allergic Rhinitis

Anatomical Context for Allergic Rhinitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Allergic Rhinitis:

33
Skin, Liver, Lymph node, Lung, Spleen, Bone marrow, Thymus, Heart, Small intestine, Adrenal gland, Tonsil, Monocytes, Nk cells, T cells, B cells, Endothelial, Bronchial epithelium

Animal Models for Allergic Rhinitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Allergic Rhinitis

Sources:
51PubMed
See all sources

Articles related to Allergic Rhinitis:

(show top 50)    (show all 1181)
idTitleAuthorsYear
1
Investigation of poly (adp-ribose) polymerase-1 genetic variants as a possible risk for allergic rhinitis. (24180296)
2014
2
The impact of concomitant allergic rhinitis on asthma control: a cross-sectional nationwide survey in China. (24000784)
2014
3
Identification of nasal bacterial flora profile and carriage rates of methicillin-resistant Staphylococcus aureus in patients with allergic rhinitis. (23591798)
2014
4
High-intensity focused ultrasound for the treatment of allergic rhinitis using nasal endoscopy. (23251291)
2013
5
End-organ testing for allergic rhinitis with fungi is poorly correlated with fungal sensitivity. (23325707)
2013
6
Development and validation of a 5-day-ahead hay fever forecast for patients with grass-pollen-induced allergic rhinitis. (23780494)
2013
7
Allergic rhinitis: can we identify nonadherence to therapy and its predictors easily in daily practice? (24260976)
2013
8
Specific patterns of allergic sensitization in early childhood and asthma & rhinitis risk. (23331564)
2013
9
Gene polymorphisms of Interleukin-4 in allergic rhinitis and its association with clinical phenotypes. (24075353)
2013
10
Nasal high-mobility group box-1 protein in children with allergic rhinitis. (23343652)
2013
11
The effect of combined medical treatment on quality of life in persistent allergic rhinitis. (24427672)
2013
12
Economic evaluation of 5-grass pollen tablets versus placebo in the treatment of allergic rhinitis in adults. (23532801)
2013
13
A four-way, double-blind, randomized, placebo controlled study to determine the efficacy and speed of azelastine nasal spray, versus loratadine, and cetirizine in adult subjects with allergen-induced seasonal allergic rhinitis. (23635091)
2013
14
Allergic rhinitis as a possible risk factor for malocclusion: a case-control study in children. (23017035)
2013
15
Efficacy and safety of a once-daily sublingual immunotherapy without escalation regimen in house dust mite-induced allergic rhinitis. (23044892)
2013
16
Cost-effectiveness for acupuncture in seasonal allergic rhinitis: economic results of the ACUSAR trial. (23806461)
2013
17
Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis. (23710953)
2013
18
Association between allergic rhinitis and asthma in a Northern Alberta cohort. (24350985)
2013
19
HIF-1I+ inhibition reduces nasal inflammation in a murine allergic rhinitis model. (23133644)
2012
20
Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis. (22918213)
2012
21
An antagonist for CCR4 alleviates murine allergic rhinitis by intranasal administration. (22739408)
2012
22
PI3-kinase regulates eosinophil and neutrophil degranulation in patients with allergic rhinitis and allergic asthma irrespective of allergen challenge model. (21384093)
2012
23
The expression of mucins gene in the human nasal polyps and allergic rhinitis]. (20128280)
2009
24
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. (19608418)
2009
25
Soluble serum HLA-G and HLA-A, -B, -C molecules in patients with seasonal allergic rhinitis exposed to pollens. (19410660)
2009
26
Vascular endothelial growth factor produced in nasal glands of perennial allergic rhinitis. (18702899)
2008
27
Increased expression of pigment epithelium-derived factor in allergic rhinitis. (18936358)
2008
28
Applicability and reproducibility of biomarkers for the evaluation of anti-inflammatory therapy in allergic rhinitis. (19123434)
2008
29
Relationship between soluble HLA-G and HLA-A,-B,-C serum levels, and interferon-gamma production after sublingual immunotherapy in patients with allergic rhinitis. (18573288)
2008
30
FcgammaRIIIa-V/F 158 polymorphism in Turkish children with asthma bronchiale and allergic rhinitis. (18199088)
2008
31
Glycoconjugate expression in perennial allergic rhinitis: a lectin histopathological study. (17851894)
2007
32
Serum leptin levels and lipid profiles in patients with allergic rhinitis and mild asthma. (18047813)
2007
33
Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. (17181111)
2006
34
The expression of transforming growth factor beta1, interleukin-6, 11 and 17 in nasal mucosa of allergic rhinitis patients]. (17017182)
2006
35
Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis. (17165277)
2006
36
Seasonal non-allergic rhinitis (SNAR)--a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis. (16008061)
2005
37
Safety and tolerability of treatments for allergic rhinitis in children. (15366976)
2004
38
Inflammatory mediators in allergic rhinitis. (15536444)
2004
39
Efficacy of ebastine in the control of nasal congestion associated with allergic rhinitis. (12731456)
2003
40
Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways. (12752585)
2003
41
Desloratadine activity in concurrent seasonal allergic rhinitis and asthma. (11243501)
2001
42
Serum soluble tumor necrosis factor receptor levels in patients with seasonal allergic rhinitis. (11436971)
2001
43
Intranasal capsaicin is lacking therapeutic effect in perennial allergic rhinitis to house dust mite. A placebo-controlled study. (11122219)
2000
44
Comparison of sinusitis with and without allergic rhinitis: characteristics of paranasal sinus effusion and mucosa. (10326748)
1999
45
Cry j 1-induced synthesis of interleukin-5 and interferon-gamma by peripheral blood mononuclear cells of patients with seasonal allergic rhinitis due to Japanese cedar pollens. (9879414)
1998
46
Serum levels of soluble interleukin-2 receptor in patients with perennial allergic rhinitis before and after immunotherapy. (8814045)
1996
47
Proinflammatory cytokines in allergic rhinitis. (7537566)
1995
48
Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators. (1741538)
1991
49
Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin. (1742652)
1991
50
Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders. (1715267)
1991

Genetic Variations for Allergic Rhinitis

Expression for genes affiliated with Allergic Rhinitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Allergic Rhinitis

Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for genes affiliated with Allergic Rhinitis

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Pathways related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3CCL24, IL4, IL4R, IL9, IL5, IL13
2
Hide members
11.3CCL24, CCL11, CCL13, CCR3, IL13, IL5
3
Hide members
11.3IL4R, IL9, IL5, IL13, CCR3, CCL13
4
Hide members
11.2CCL11, EPX, RNASE3, IL13, IL5, IL9
5
Hide members
11.2CCL24, CCL11, CCL13, IL13, IL5, IL9
6
Hide members
11.2CCL24, CCL11, CCR3, IL13, IL5, IL9
7
Hide members
11.0CCL11, IGHE, IL13, IL5, IL4R, IL4
810.9IL4, IL4R, IL9, IL5, IL13
910.9IL13, IL5, IL9, IL4R, IL4
10
Hide members
10.9IL17A, IL4, IL4R, IL5, IL13
1110.9CCL11, IGHE, IL5, IL4R, IL4
1210.8IL13, IL5, IL9, IL4
1310.8IL13, IL5, IL9, IL4
14
Hide members
10.8IL5, IL9, IL4, IL17A
15
Immune response CCR3 signaling in eosinophils
Hide members
10.8CCR3, CCL13, CCL11, CCL24
16
Hide members
10.8CCL24, CCL11, CCL13, CCR3
1710.8IL4, IL5, IL13
1810.8CCL11, IL5, IL4
1910.8IL4, IL4R, IL5
2010.8IL5, IL4R, IL4
21
Hide members
10.8IL17A, IL4, IL4R

Compounds for genes affiliated with Allergic Rhinitis

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1histamine45 29 2414.2IL5, CCL24, CCL11, CCL13, CCR3, IGHE
2dexamethasone45 50 29 1115.1CCL11, CCR3, IGHE, NGF, EPX, RNASE3
3tyrosine4511.9IL4R, HAVCR1, NGF, CCR3, CCL11, IL13
4allergens4511.8CCL11, HRH1, RNASE3, IL4, IGHE, EPX
5tarc4511.8IL9, CCL24, CCL11, IL4, IL4R, IL5
6cyclosporin a45 29 6013.8IL13, CCL11, IGHE, NGF, RNASE3, HRH1
7thymidine45 2412.8CCR3, CCL11, IL13, IL5, HRH1, NGF
8actinomycin d4511.7IL4R, NGF, IGHE, CCR3, CCL11, CCL24
9methacholine45 1112.7CCL11, IGHE, IL17A, IL4, IL9, RNASE3
10steroid4511.6IL4R, RNASE3, IL17A, EPX, CCL11, CCL13
11rantes4511.6CCL11, RNASE3, IL9, IL4R, IL4, IL17A
12budesonide45 50 1113.6IL5, IL13, RNASE3, IL4, IGHE, CCL11
13pgd24511.6IGHE, IL5, IL13, RNASE3, CCR3, CCL11
14prednisolone45 29 1113.5RNASE3, EPX, NGF, IGHE, CCL11, IL5
15ionomycin4511.5IL9, IL5, IL13, IL17A, IL4, CCL11
16adenylate4511.5IGHE, HRH1, IL4, IL5, IL13, RNASE3
17sodium cromoglycate4511.5EPX, CCL11, IGHE, HRH1, IL5, RNASE3
18cetirizine45 29 11 2414.5CCL11, HRH1, IL5, RNASE3, EPX, IGHE
19salmeterol45 50 29 1114.5EPX, CCL11, IL4, RNASE3, IL13, IL5
20montelukast45 50 29 1114.5IL4, IL5, IL13, IGHE, CCL11, RNASE3
21ketotifen45 1112.5HRH1, RNASE3, EPX, IGHE, CCL11, IL5
22salbutamol45 50 29 11 2415.4CCL11, IGHE, EPX, RNASE3, IL13, IL5
23fluticasone propionate45 50 60 1114.4CCL11, IGHE, RNASE3, IL13, IL4, IL5
24nedocromil sodium4511.3IL5, HRH1, IL4, RNASE3, IGHE
25praziquantel45 1112.3IL13, IL4, IL5, IGHE, RNASE3
26azelastine45 1112.3IL5, RNASE3, IGHE, HRH1, IL4
27ltd44511.3HRH1, IL5, IL13, RNASE3, CCR3
28ltc44511.3CCL11, EPX, IL5, IL13, RNASE3
29vegf4511.3IL4, IGHE, IL13, IL5, NGF, IL17A
30tacrolimus45 50 1113.2CCL11, IL13, IL17A, IL4, IL5, HRH1
31unicap4511.2IL5, IGHE, CCL11, RNASE3
32omalizumab45 1112.2IL5, IGHE, IL13, IL4
33capsaicin45 2912.2RNASE3, NGF, IGHE, IL5, HRH1
34anti-histamine4511.2CCL11, IGHE, RNASE3, HRH1
35lte44511.2CCL11, IL5, EPX, RNASE3
36aspirin45 50 29 2414.2HRH1, CCL11, IL13, IL4, RNASE3, NGF
37desloratadine45 1112.2IL4, HRH1, IL13, IGHE
38theophylline45 29 11 2414.2IL13, IL5, EPX, RNASE3, NGF
39indomethacin45 60 29 1114.1NGF, IL5, HRH1
40pranlukast45 29 1113.1CCL11, RNASE3, IL5, IL4
41leukotriene b445 60 2413.1IL5, IL13, RNASE3, EPX, CCL11
42sb 20358045 6012.0IL13, IL5, IL4, IL17A, CCL11, NGF
43endotoxin4511.0RNASE3, HRH1, SCGB1A1
44pge24511.0EPX, CCL11
45levocetirizine4510.9CCL11, IL4, HRH1
46ovomucoid4510.9IGHE
47rolipram45 60 2912.9EPX
48creatinine4510.8NGF, RNASE3, IGHE, HRH1, EPX, SCGB1A1
49oxatomide4510.8HRH1, IGHE, IL5
50levocabastine45 29 1112.7RNASE3, IL5, HRH1

GO Terms for genes affiliated with Allergic Rhinitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.6IL17A, CCL11, CCL13, CCR3, SCGB1A1, NGF

Biological processes related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.7HRH1, CCL24, CCL11, CCL13, CCR3, NGF
2immune responseGO:00695511.7CCL24, CCL11, CCL13, IGHE, IL13, IL5
3eosinophil chemotaxisGO:04824511.2CCL24, CCL11, CCL13, CCR3, HRH1
4chemotaxisGO:00693511.2CCL24, CCL11, CCL13, CCR3, IL4
5signal transductionGO:00716511.1CCL24, CCL11, CCL13, SCGB1A1, IL13, IL4R
6positive regulation of B cell proliferationGO:03089011.0IL4, IL5, IL13
7cell-cell signalingGO:00726711.0CCL24, CCL13, IL13, IL17A
8positive regulation of endothelial cell proliferationGO:00193811.0CCR3, CCL11, CCL24
9response to ozoneGO:01019310.9SCGB1A1, NGF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.9IL4, IL5, NGF
11negative regulation of interleukin-5 productionGO:03271410.9SCGB1A1, EPX
12regulation of proton transportGO:01015510.9IL13, IL4
13mast cell chemotaxisGO:00255110.9CCL11, CCR3
14positive regulation of angiogenesisGO:04576610.8CCR3, CCL11, CCL24
15positive regulation of macrophage activationGO:04303210.8IL13, IL4R
16response to lipopolysaccharideGO:03249610.8IL13, NGF, SCGB1A1
17cytoskeleton organizationGO:00701010.8CCL24, CCL11, CCL13
18regulation of cell shapeGO:00836010.7CCL13, CCL11, CCL24
19defense response to protozoanGO:04283210.4IL4, IL4R

Molecular functions related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.8IL17A, IL4, IL9, IL5, IL13
2chemokine activityGO:00800910.8CCL13, CCL11, CCL24
3growth factor activityGO:00808310.5NGF, IL5, IL9, IL4

Products for genes affiliated with Allergic Rhinitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Rhinitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet