MCID: ALL003
MIFTS: 73

Allergic Rhinitis malady

Respiratory diseases, Immune diseases categories
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Summaries for Allergic Rhinitis

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MedlinePlus:33 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat red and watery eyes dark circles under the eyes your health care provider may diagnose hay fever based on a physical exam and your symptoms. sometimes skin or blood tests are used. taking medicines and using nasal sprays can relieve symptoms. you can also rinse out your nose, but be sure to use distilled or sterilized water with saline. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases

MalaCards based summary: Allergic Rhinitis, also known as hay fever, is related to asthma and rhinitis. An important gene associated with Allergic Rhinitis is IL13 (interleukin 13), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The drugs beclomethasone and beclomethasone dipropionate and the compounds lte4 and unicap have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Disease Ontology:8 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

Wikipedia:65 Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as... more...

Description from OMIM:46 607154

Aliases & Classifications for Allergic Rhinitis

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Allergic Rhinitis, Aliases & Descriptions:

Name: Allergic Rhinitis 8 46 10 44 62
Hay Fever 8 33 62
Allergic Rhinitis Due to Pollen 8 62
Non-Seasonal Allergic Rhinitis 8 62
Allergic Rhinitis Due to Food 8 62
Allergy to Pollen 8 62
Pollenosis 8 62
Allergic Rhinitis Due to Animal Hair and Dander 8
 
Allergic Rhinitis, Susceptibility to 9
Rhinitis, Allergic, Seasonal 62
Rhinitis Allergic Seasonal 44
Seasonal Allergic Rhinitis 8
Perenial Allergic Rhinitis 8
Hay Fever - Pollens 8
Atopic Rhinitis 8
Pollinosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:4481
NCIt39 C34987
SNOMED-CT57 38103000
OMIM46 607154
ICD1025 J30.1

Related Diseases for Allergic Rhinitis

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Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.5IL13, CCL11
2rhinitis32.1IGES, IGHE, RNASE3, EPX, CCL11, IL4
3conjunctivitis31.4IGES, IGHE, RNASE3, HRH1
4urticaria31.4IGHE, RNASE3, HRH1
5sinusitis31.3IGES, IGHE, IL5, RNASE3, CCL11
6common cold31.2CCL11, RNASE3
7otitis media31.2RNASE3, IGHE, IGES, CCL11
8chronic rhinitis30.9RNASE3, HRH1
9giant papillary conjunctivitis30.8IL5, CCL11, RNASE3
10allergic bronchopulmonary aspergillosis30.8IL5, IGHE, IGES, IL4
11churg-strauss syndrome30.8RNASE3, IL5
12keratoconjunctivitis30.7RNASE3, CCL11, IL5, IL13
13allergic conjunctivitis30.7IGHE, RNASE3, CCL11, IL4, IL5, IL13
14graves' disease30.6IL4R, IL13, IGES, IL4
15cystic fibrosis30.5RNASE3, IL9, IGES, CCL17, IL17A
16atopic dermatitis30.4IL4, CCL13, CCL11, CCL17, NGF, RNASE3
17food allergy30.3IL5, IL13, RNASE3, EPX, CCL11, IL4
18dermatitis30.3IL17A, IL13, IGES, IGHE, CCL17, CCL11
19tuberculosis30.3EPX, IL4, IGES, IL4R, IL17A
20atopy30.1HAVCR1, IGES, IL13, IL9, IL4R, IL5
21eosinophilia30.0EPX, RNASE3, NGF, IGHE, IGES, CCL17
22vernal keratoconjunctivitis30.0IL4, IL5, IL13, IGHE, IGES, NGF
23leukemia29.8IL17A, EPX, HRH1, IL9, CCL11, IL4
24allergic asthma29.3IL4R, IL17A, IL5, IL4, CCL13, CCL11
25blindness10.8
26bronchitis10.6RNASE3
27malaria10.6HRH1
28folliculitis10.6CCL11
29vasomotor rhinitis10.5
30eosinophilic esophagitis10.5CCL11, IL5
31endotheliitis10.5
32strongyloidiasis10.5IL5, IGHE
33anisakiasis10.4IGHE, RNASE3
34toxocariasis10.4IGHE, RNASE3
35corneal ulcer10.4NGF, CCL11
36cystitis10.4NGF
37chronic eosinophilic pneumonia10.4IL5, RNASE3, CCL11
38eosinophilic gastroenteritis10.4CCL11, IL5, IGHE
39contact dermatitis10.4IL5, IGHE
40esophagitis10.4IL13, IL5, CCL11
41filariasis10.4IGHE, IL5, IL13
42proctitis10.4RNASE3, EPX
43collagenous colitis10.4RNASE3
44lipoid nephrosis10.4IL13, IL4R
45immunodeficiency with hyper igm type 110.4IGHE, IL4
46bronchiectasis10.4IGHE, IGES, RNASE3
47onchocerciasis10.4RNASE3, IL5, EPX
48adenoiditis10.4
49neuronitis10.4
50nasopharyngitis10.4

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to allergic rhinitis

Symptoms for Allergic Rhinitis

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Clinical features from OMIM:

607154

Drugs & Therapeutics for Allergic Rhinitis

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Drug clinical trials:

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Search NIH Clinical Center for Allergic Rhinitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Allergic Rhinitis

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Anatomical Context for Allergic Rhinitis

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MalaCards organs/tissues related to Allergic Rhinitis:

32
Skin, Eye, Testes, T cells, Neutrophil, Endothelial, Lung, B cells, Bone, Tonsil, Bone marrow, Lymph node, Thymus, Heart, Liver, Salivary gland, Monocytes, Nk cells

Animal Models for Allergic Rhinitis or affiliated genes

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MGI Mouse Phenotypes related to Allergic Rhinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7IL13, IL9, IL4R, IL17A, IL5, IL4
2MP:00053768.4IL13, IL9, IL4R, IL17A, IL5, IL4
3MP:00053888.3HAVCR1, IL13, IL4R, IL17A, IL4, IL5
4MP:00053977.3IGHE, EPX, CCL17, CCL24, CCL11, HRH1
5MP:00053877.0HRH1, IGHE, EPX, CCL17, CCL24, CCL11

Publications for Allergic Rhinitis

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Articles related to Allergic Rhinitis:

(show top 50)    (show all 1128)
idTitleAuthorsYear
1
Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: A proteomic study. (25363381)
2014
2
Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis. (23278877)
2013
3
A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoate aqueous nasal spray in patients with perennial allergic rhinitis. (24079722)
2013
4
Effects of dietary habits and risk factors on allergic rhinitis prevalence among Turkish adolescents. (23820188)
2013
5
Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis. (24067337)
2013
6
Clara cell 10-kDa protein inhibits T(H)17 responses through modulating dendritic cells in the setting of allergic rhinitis. (23273949)
2013
7
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. (23346908)
2013
8
Sequential engagement of FcI/RI on Mast Cells and Basophil Histamine H(4) Receptor and FcI/RI in Allergic Rhinitis. (23241885)
2013
9
Interleukin-4 receptor I+-chain polymorphisms and susceptibility to allergic rhinitis: a meta-analysis. (24337880)
2013
10
Comparison of mometasone furoate monohydrate (Nasonex) and fluticasone propionate (Flixonase) nasal sprays in the treatment of dust mite-sensitive children with perennial allergic rhinitis. (23597528)
2013
11
Safety and efficacy of Nasya/Prevalin in reducing symptoms of allergic rhinitis. (24279907)
2013
12
Nasal mucosa temperature as a marker of disease in children with allergic rhinitis. (22801008)
2012
13
A critical role of IL-33 in experimental allergic rhinitis. (22460070)
2012
14
Targeting the priming response: intranasal steroid therapy for allergic rhinitis. (22530547)
2012
15
The burden of allergic rhinitis (AR) in Canada: perspectives of physicians and patients. (22656186)
2012
16
Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. (23040884)
2012
17
HIF-1I+ inhibition reduces nasal inflammation in a murine allergic rhinitis model. (23133644)
2012
18
Diabetogenic effects of Parthinium hysterophorous induced allergic rhinitis. (22708969)
2012
19
Diminished levels of nasal S100A7 (psoriasin) in seasonal allergic rhinitis: an effect mediated by Th2 cytokines. (22230654)
2012
20
Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model. (23554753)
2012
21
Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells. (22687252)
2012
22
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
23
A preliminary study on the regulation mechanism of p38MAPK on MUC5AC in allergic rhinitis]. (22239058)
2011
24
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
25
Development of a questionnaire to assess experience and preference of intranasal corticosteroids in patients with allergic rhinitis. (22915972)
2011
26
Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma. (22289536)
2011
27
Variability of the L-Histidine decarboxylase gene in allergic rhinitis. (20608921)
2010
28
Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. (20482305)
2010
29
Peripheral Th-17 cells in allergic rhinitis: New evidence. (19925886)
2010
30
A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. (19222422)
2009
31
Does pregnancy-associated plasma protein A have a role in allergic rhinitis? (18588751)
2008
32
Leukotrien antagonists in the treatment of allergic rhinitis and comorbidities]. (19058495)
2008
33
Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]. (18260253)
2007
34
Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis. (17091279)
2007
35
TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitis. (17982230)
2007
36
Expression of interleukin 4 and 13 measured in patients with allergic rhinitis]. (17633285)
2007
37
Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. (17181111)
2006
38
Suppressive effect of fluticasone propionate on MMP expression in the nasal mucosa of allergic rhinitis patients in vivo. (16900772)
2006
39
Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. (17072057)
2006
40
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
41
Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between upper and lower airways. (16734115)
2004
42
The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance]. (12412419)
2002
43
Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. (10768732)
2000
44
In vivo expression of signal transducer and activator of transcription factor 6 (STAT6) in nasal mucosa from atopic allergic rhinitis: effect of topical corticosteroids. (10606935)
2000
45
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
46
Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis]. (9585822)
1998
47
The influence of 5-lipoxygenase inhibition in allergic rhinitis. (7613199)
1995
48
Proinflammatory cytokines in allergic rhinitis. (7537566)
1995
49
Neuropeptides of the nasal innervation and allergic rhinitis]. (7526427)
1994
50
Humoral response to subcutaneous, oral, and nasal immunotherapy for allergic rhinitis due to Dermatophagoides pteronyssinus. (7755664)
1993

Variations for Allergic Rhinitis

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Expression for genes affiliated with Allergic Rhinitis

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Expression patterns in normal tissues for genes affiliated with Allergic Rhinitis

Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for genes affiliated with Allergic Rhinitis

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Pathways related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL4, IL4R
29.9IL13, IL5, IL4
39.9IL4, IL5, IL13
49.9CCL11, IL4, IL5
59.9IL4R, IL5, IL4
69.9IL4, IL5, IL4R
7
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.9IL9, IL4R, IL4
8
Show member pathways
9.8IL4R, IL17A, IL4
9
Show member pathways
9.8CCL13, CCL11, CCL24
109.7IL4, IL5, IL9, IL13
119.7IL13, IL9, IL5, IL4
12
Show member pathways
9.6IL9, IL4R, IL4, CCL13
13
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.6IGHE, CCL11, IL4, IL4R
14
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.6IGHE, IL4, IL5, IL13
15
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.6IL4, IL5, IL17A, IL9
169.5IL4, IL5, IL4R, IL9, IL13
17
Show member pathways
Type III interferon signaling37
9.5IL13, IL9, IL4R, IL5, IL4
18
Show member pathways
9.5IL4, IL5, IL17A, IL4R, IL13
199.2IGHE, CCL17, CCL11, IL4, IL5, IL4R
20
Show member pathways
9.1CCL13, CCR8, CCL11, CCL24, CCL17
21
Show member pathways
9.1CCL13, CCR8, CCL11, CCL24, CCL17
22
Show member pathways
9.1CCL17, CCL24, CCL11, CCR8, CCL13
23
Show member pathways
8.9RNASE3, EPX, CCL11, IL4, IL5, IL4R
24
Show member pathways
8.5CCL17, CCL24, CCL11, CCL13, IL4, IL5
25
Show member pathways
8.1CCL17, IL13, IL9, IL4R, IL5, IL4
26
Show member pathways
8.1CCL17, CCL24, CCL11, CCR8, CCL13, IL4
27
Show member pathways
8.1IL9, IL4R, IL5, IL4, CCL13, CCR8
28
Show member pathways
7.9IL13, CCL17, CCL24, CCL11, CCR8, CCL13

Compounds for genes affiliated with Allergic Rhinitis

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Compounds related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1lte44410.0RNASE3, EPX, CCL11, IL5
2unicap4410.0IGHE, RNASE3, IL5, CCL11
3omalizumab44 1111.0IL5, IL13, IL4, IGHE
4pranlukast44 28 1111.9RNASE3, IL5, IL4, CCL11
5ltc4449.9RNASE3, EPX, CCL11, IL5, IL13
6ovomucoid449.9IL5, IL4, IL13, IGHE
7rolipram44 61 2811.8CCL11, IL4, IL5, IL13, EPX
8praziquantel44 1110.8RNASE3, IL13, IL5, IL4, IGHE
9salmeterol44 50 28 1112.8RNASE3, EPX, CCL11, IL4, IL5, IL13
10il 10449.8IL13, IL4R, IL5, IL4, CCL17
11anti-histamine449.8RNASE3, IGHE, CCL11, HRH1
12levocetirizine449.7HRH1, IL4, CCL11
13theophylline44 28 24 1112.7IL5, IL13, NGF, EPX, RNASE3
14desloratadine44 1110.7IGHE, HRH1, IL13, IL4
15ltd4449.7IL5, HRH1, IL13, RNASE3
16salbutamol44 50 28 24 1113.7EPX, CCL11, IL5, RNASE3, IGHE, IL13
17pgd2449.7IL5, IL13, EPX, IGHE, RNASE3, CCL11
18montelukast44 50 28 1112.7CCL11, IL4, IL5, IL13, IGHE, RNASE3
19fluticasone propionate44 50 61 1112.6IGHE, IL5, RNASE3, CCL11, IL4, IL13
20nedocromil sodium449.6IL4, RNASE3, IL5, HRH1, IGHE
21azelastine44 1110.6RNASE3, IL4, IL5, HRH1, IGHE
22sodium cromoglycate449.5EPX, CCL11, IL5, HRH1, RNASE3, IGHE
23cetirizine44 28 24 1112.5IGHE, EPX, RNASE3, CCL11, IL5, HRH1
24prednisolone44 28 1111.5NGF, CCL11, IL5, IL13, EPX, RNASE3
25budesonide44 50 1111.5IGHE, RNASE3, EPX, CCL11, IL4, IL5
26leukotriene b444 61 2411.5IL5, CCL11, EPX, RNASE3, IL13
27ionomycin449.5CCL11, IL4, IL5, IL17A, IL4R, IL9
28ketotifen44 1110.5IGHE, RNASE3, CCL11, IL5, HRH1, EPX
29ccl444 2810.5CCL17, IL13, CCR8, CCL11, IL17A
30capsaicin44 2810.4IGHE, HRH1, RNASE3, IL5, NGF
31ccl344 2810.4IL13, CCL11, CCL24, CCL17, CCR8
32aspirin44 50 28 2412.2CCL11, IL13, RNASE3, HRH1, NGF, IGES
33tacrolimus44 50 1111.2CCL11, CCL17, IL5, IL13, HRH1, IL4
34pge2449.1IL17A, RNASE3, EPX, HRH1, IL13, CCL11
35actinomycin d449.0NGF, CCL24, CCL11, IL13, IL4R, IL17A
36sb 20358044 6110.0NGF, IL13, IL5, IL4, CCL11, IL17A
37indomethacin44 28 61 1112.0IGHE, NGF, CCL11, IL4, IL5, IL17A
38thymidine44 249.9IL4R, IL9, IL13, HRH1, NGF, IL17A
39methacholine44 50 1110.9IL13, IL9, IL17A, IL5, IL4, CCL11
40vegf448.9IGHE, IL13, IL17A, IL5, NGF, RNASE3
41adenylate448.8HRH1, IL13, IL5, IL4, RNASE3, NGF
42steroid448.8CCL24, IL13, IL4R, IL17A, CCL13, EPX
43nitric oxide44 24 1110.6HRH1, IL13, IL9, IL17A, CCL11, IGES
44tyrosine448.5IL13, IL9, IL4R, IL17A, IL5, IL4
45tarc448.2CCL17, IGHE, CCL13, CCR8, IL5, IL4R
46cyclosporin a44 28 6110.2IGES, IGHE, HRH1, IL13, IL4R, IL17A
47allergens448.1IGHE, RNASE3, EPX, CCL17, CCL11, IGES
48dexamethasone44 50 28 1111.0CCL17, IL4R, HRH1, CCL13, IL17A, EPX
49rantes447.8HRH1, IL13, IL9, IL4R, IL17A, IL5
50histamine44 28 249.7IGES, IGHE, HRH1, IL13, IL9, IL4R

GO Terms for genes affiliated with Allergic Rhinitis

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Cellular components related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.0NGF, RNASE3, CCL17, CCL11, IL5, IL13
2extracellular spaceGO:0056157.8IL13, NGF, CCL17, CCL24, CCL11, CCL13

Biological processes related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage activationGO:04303210.3IL4R, IL13
2regulation of proton transportGO:01015510.3IL13, IL4
3defense response to protozoanGO:04283210.1IL4R, IL4
4positive regulation of B cell proliferationGO:03089010.1IL13, IL5, IL4
5positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.1IL5, IL4, NGF
6response to nicotineGO:03509410.0NGF, IL13
7positive regulation of Rac GTPase activityGO:03285510.0CCL11, CCL24
8cytoskeleton organizationGO:0070109.9CCL13, CCL11, CCL24
9regulation of cell shapeGO:0083609.9CCL24, CCL11, CCL13
10response to radiationGO:0093149.8NGF, CCL11
11eosinophil chemotaxisGO:0482459.7CCL24, CCL11, CCL13, HRH1
12cell-cell signalingGO:0072679.5CCL17, CCL24, CCL13, IL17A, IL13
13signal transductionGO:0071659.4IL13, IL4R, CCL13, CCL11, CCL24
14chemotaxisGO:0069359.2CCL17, CCL24, CCL11, CCR8, CCL13, IL4
15inflammatory responseGO:0069548.4IL13, IL9, IL17A, IL5, CCL13, CCL11
16immune responseGO:0069557.9IL13, IGHE, CCL17, IL9, IL4R, IL17A

Molecular functions related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.7IL9, IL5, IL4, NGF
2chemokine activityGO:0080099.4CCL13, CCL11, CCL24, CCL17
3cytokine activityGO:0051259.1IL4, IL5, IL17A, IL9, IL13

Products for genes affiliated with Allergic Rhinitis

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Sources for Allergic Rhinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
43NINDS
44Novoseek
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58SNOMED-CT via Orphanet
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63UMLS via Orphanet