MCID: ALL003
MIFTS: 72

Allergic Rhinitis malady

Genetic diseases (common), Respiratory diseases, Immune diseases categories

Summaries for Allergic Rhinitis

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MedlinePlus:34 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat red and watery eyes dark circles under the eyes your health care provider may diagnose hay fever based on a physical exam and your symptoms. sometimes skin or blood tests are used. taking medicines and using nasal sprays can relieve symptoms. you can also rinse out your nose, but be sure to use distilled or sterilized water with saline. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases

MalaCards based summary: Allergic Rhinitis, also known as hay fever, is related to rhinitis and asthma. An important gene associated with Allergic Rhinitis is IL13 (interleukin 13), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The drugs dexamethasone and dexamethasone acetate and the compounds lte4 and unicap have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Disease Ontology:10 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

Wikipedia:65 Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as... more...

Description from OMIM:47 607154

Aliases & Classifications for Allergic Rhinitis

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Allergic Rhinitis, Aliases & Descriptions:

Name: Allergic Rhinitis 47 10 12 45 62
Hay Fever 10 34 62
Allergic Rhinitis Due to Pollen 10 62
Non-Seasonal Allergic Rhinitis 10 62
Allergic Rhinitis Due to Food 10 62
Allergy to Pollen 10 62
Pollenosis 10 62
Allergic Rhinitis Due to Animal Hair and Dander 10
 
Allergic Rhinitis, Susceptibility to 11
Rhinitis, Allergic, Seasonal 62
Perenial Allergic Rhinitis 10
Seasonal Allergic Rhinitis 10
Rhinitis Allergic Seasonal 45
Hay Fever - Pollens 10
Atopic Rhinitis 10
Pollinosis 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases, Immune diseases


External Ids:

OMIM47 607154
Disease Ontology10 DOID:4481
SNOMED-CT57 38103000
NCIt40 C34987
ICD1027 J30.1

Related Diseases for Allergic Rhinitis

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Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1rhinitis32.4IL13, IL9, IL5, IL4, CCL11, EPX
2asthma31.9CCL11, IL13
3sinusitis31.0IGES, IGHE, RNASE3, CCL11, IL5
4conjunctivitis31.0HRH1, RNASE3, IGHE, IGES
5urticaria31.0IGHE, RNASE3, HRH1
6atopy30.8IL9, IL4R, IL5, IL4, CCL11, CCL17
7eosinophilia30.8IL5, IL4, CCL13, CCL11, CCL24, CCL17
8otitis media30.8IGES, IGHE, RNASE3, CCL11
9allergic asthma30.7CCL11, CCL24, CCL17, EPX, RNASE3, NGF
10common cold30.7RNASE3, CCL11
11allergic conjunctivitis30.6HRH1, IL13, IL5, IL4, CCL11, RNASE3
12dermatitis30.5RNASE3, IGHE, IGES, CCL17, IL4, IL13
13allergic bronchopulmonary aspergillosis30.5IGES, IGHE, IL4, IL5
14cystic fibrosis30.4IGES, RNASE3, CCL17, IL17A, IL9
15food allergy30.4IGES, IL13, IL5, IL4, CCL11, EPX
16atopic dermatitis30.3HRH1, IL13, IL9, IL4R, IL17A, IL5
17bronchitis30.3RNASE3
18chronic rhinitis30.3HRH1, RNASE3
19churg-strauss syndrome30.3RNASE3, IL5
20keratoconjunctivitis30.2IL13, IL5, CCL11, RNASE3
21graves' disease30.2IGES, IL4, IL4R, IL13
22tuberculosis30.2IGES, EPX, IL4, IL17A, IL4R
23vernal keratoconjunctivitis30.2IL13, IL5, IL4, CCL11, CCL24, RNASE3
24leukemia30.1NGF, RNASE3, EPX, CCL11, IL4, IL17A
25blindness10.8
26vasomotor rhinitis10.5
27endotheliitis10.5
28neuronitis10.4
29nasopharyngitis10.4
30sleep disorder10.4
31neurodermatitis10.3
32pulmonary function10.3
33aspergillosis10.3
34nasopharyngeal carcinoma10.3
35migraine10.3
36tonsillitis10.3
37adenoiditis10.3
38netherton syndrome10.1
39lung cancer10.1
40attention deficit-hyperactivity disorder10.1
41osteoporosis10.1
42immunodeficiency 2310.1
43familial cold autoinflammatory syndrome 310.1
44exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.1
45obesity10.1
46common variable immunodeficiency10.1
47pulmonary tuberculosis10.1
48obstructive sleep apnea10.1
49chronic fatigue syndrome10.1
50klippel-feil syndrome10.1

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to allergic rhinitis

Symptoms for Allergic Rhinitis

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Clinical features from OMIM:

607154

Drugs & Therapeutics for Allergic Rhinitis

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Drug clinical trials:

Search ClinicalTrials for Allergic Rhinitis

Search NIH Clinical Center for Allergic Rhinitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Allergic Rhinitis

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Anatomical Context for Allergic Rhinitis

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MalaCards organs/tissues related to Allergic Rhinitis:

33
Skin, Eye, Testes, T cells, Neutrophil, Endothelial, Lung, B cells, Bone, Tonsil, Bone marrow, Lymph node, Thymus, Heart, Liver, Salivary gland, Monocytes, Nk cells

Animal Models for Allergic Rhinitis or affiliated genes

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MGI Mouse Phenotypes related to Allergic Rhinitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7IL13, IL9, IL4R, IL17A, IL5, IL4
2MP:00053768.4IL13, IL9, IL4R, IL17A, IL5, IL4
3MP:00053888.3HAVCR1, IL13, IL4R, IL17A, IL4, IL5
4MP:00053977.3IGHE, EPX, CCL17, CCL24, CCL11, HRH1
5MP:00053877.0HRH1, IGHE, EPX, CCL17, CCL24, CCL11

Publications for Allergic Rhinitis

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Articles related to Allergic Rhinitis:

(show top 50)    (show all 1153)
idTitleAuthorsYear
1
The impact of co-existing seasonal allergic rhinitis caused by Japanese Cedar Pollinosis (SAR-JCP) upon asthma control status. (25838090)
2015
2
Sphenopalatine ganglion stimulation with one acupuncture needle for moderate-severe persistent allergic rhinitis: study protocol for a multicenter randomized controlled trial. (25899566)
2015
3
Apolipoproteins have a potential role in nasal mucus of allergic rhinitis patients: A proteomic study. (25363381)
2014
4
Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis. (23278877)
2013
5
A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoate aqueous nasal spray in patients with perennial allergic rhinitis. (24079722)
2013
6
Effects of dietary habits and risk factors on allergic rhinitis prevalence among Turkish adolescents. (23820188)
2013
7
Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis. (24067337)
2013
8
Clara cell 10-kDa protein inhibits T(H)17 responses through modulating dendritic cells in the setting of allergic rhinitis. (23273949)
2013
9
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. (23346908)
2013
10
Sequential engagement of FcI/RI on Mast Cells and Basophil Histamine H(4) Receptor and FcI/RI in Allergic Rhinitis. (23241885)
2013
11
Interleukin-4 receptor I+-chain polymorphisms and susceptibility to allergic rhinitis: a meta-analysis. (24337880)
2013
12
Comparison of mometasone furoate monohydrate (Nasonex) and fluticasone propionate (Flixonase) nasal sprays in the treatment of dust mite-sensitive children with perennial allergic rhinitis. (23597528)
2013
13
Safety and efficacy of Nasya/Prevalin in reducing symptoms of allergic rhinitis. (24279907)
2013
14
Nasal mucosa temperature as a marker of disease in children with allergic rhinitis. (22801008)
2012
15
A critical role of IL-33 in experimental allergic rhinitis. (22460070)
2012
16
Targeting the priming response: intranasal steroid therapy for allergic rhinitis. (22530547)
2012
17
The burden of allergic rhinitis (AR) in Canada: perspectives of physicians and patients. (22656186)
2012
18
Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. (23040884)
2012
19
HIF-1I+ inhibition reduces nasal inflammation in a murine allergic rhinitis model. (23133644)
2012
20
Diabetogenic effects of Parthinium hysterophorous induced allergic rhinitis. (22708969)
2012
21
Diminished levels of nasal S100A7 (psoriasin) in seasonal allergic rhinitis: an effect mediated by Th2 cytokines. (22230654)
2012
22
Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model. (23554753)
2012
23
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
24
A preliminary study on the regulation mechanism of p38MAPK on MUC5AC in allergic rhinitis]. (22239058)
2011
25
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
26
Development of a questionnaire to assess experience and preference of intranasal corticosteroids in patients with allergic rhinitis. (22915972)
2011
27
Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma. (22289536)
2011
28
Variability of the L-Histidine decarboxylase gene in allergic rhinitis. (20608921)
2010
29
Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. (20482305)
2010
30
Peripheral Th-17 cells in allergic rhinitis: New evidence. (19925886)
2010
31
A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. (19222422)
2009
32
Does pregnancy-associated plasma protein A have a role in allergic rhinitis? (18588751)
2008
33
Endothelin-1 in nasal lavage fluid of allergic rhinitis patients--new mediator of allergic rhinitis]. (18260253)
2007
34
Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis. (17091279)
2007
35
TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitis. (17982230)
2007
36
Expression of interleukin 4 and 13 measured in patients with allergic rhinitis]. (17633285)
2007
37
Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. (17181111)
2006
38
Suppressive effect of fluticasone propionate on MMP expression in the nasal mucosa of allergic rhinitis patients in vivo. (16900772)
2006
39
Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. (17072057)
2006
40
Review of desloratadine for the treatment of allergic rhinitis, chronic idiopathic urticaria and allergic inflammatory disorders. (16259582)
2005
41
Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between upper and lower airways. (16734115)
2004
42
The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance]. (12412419)
2002
43
Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. (10768732)
2000
44
In vivo expression of signal transducer and activator of transcription factor 6 (STAT6) in nasal mucosa from atopic allergic rhinitis: effect of topical corticosteroids. (10606935)
2000
45
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
46
Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis]. (9585822)
1998
47
The influence of 5-lipoxygenase inhibition in allergic rhinitis. (7613199)
1995
48
Proinflammatory cytokines in allergic rhinitis. (7537566)
1995
49
Neuropeptides of the nasal innervation and allergic rhinitis]. (7526427)
1994
50
Humoral response to subcutaneous, oral, and nasal immunotherapy for allergic rhinitis due to Dermatophagoides pteronyssinus. (7755664)
1993

Variations for Allergic Rhinitis

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Expression for genes affiliated with Allergic Rhinitis

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Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for genes affiliated with Allergic Rhinitis

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Pathways related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL4, IL4R
29.9IL5, IL13, IL4
39.9IL4, IL13, IL5
49.9CCL11, IL5, IL4
59.9IL4R, IL5, IL4
69.9IL4R, IL5, IL4
7
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.9IL4, IL4R, IL9
8
Show member pathways
9.8IL4, IL4R, IL17A
9
Show member pathways
9.8CCL11, CCL13, CCL24
109.7IL4, IL9, IL13, IL5
119.7IL5, IL4, IL13, IL9
12
Show member pathways
9.6CCL13, IL4, IL9, IL4R
13
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.6CCL11, IL4, IL4R, IGHE
14
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.6IL4, IL13, IL5, IGHE
15
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.6IL17A, IL5, IL4, IL9
169.5IL4, IL13, IL5, IL4R, IL9
17
Show member pathways
Type III interferon signaling38
9.5IL13, IL4, IL5, IL4R, IL9
18
Show member pathways
9.5IL17A, IL13, IL4R, IL5, IL4
199.2CCL11, IL4R, IL5, IL4, CCL17, IGHE
20
Show member pathways
9.1CCL17, CCL24, CCL13, CCL11, CCR8
21
Show member pathways
9.1CCL11, CCL17, CCR8, CCL24, CCL13
22
Show member pathways
9.1CCL13, CCL11, CCL24, CCL17, CCR8
23
Show member pathways
8.9IL13, IL5, IL4, CCL11, EPX, IL9
24
Show member pathways
8.5CCL17, CCL24, CCL11, CCL13, IL4, IL5
25
Show member pathways
8.1CCL17, IL4, CCL24, CCR8, CCL13, IL5
26
Show member pathways
8.1CCL11, CCL24, CCL17, IL4, IL5, IL9
27
Show member pathways
8.1CCL11, CCL24, IL4R, CCL17, IL4, IL13
28
Show member pathways
7.9IL9, IL13, IL4R, IL17A, IL5, IL4

Compounds for genes affiliated with Allergic Rhinitis

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Compounds related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1lte44510.0RNASE3, EPX, CCL11, IL5
2unicap4510.0IGHE, RNASE3, IL5, CCL11
3omalizumab45 1311.0IL5, IL13, IL4, IGHE
4pranlukast45 30 1311.9RNASE3, IL5, IL4, CCL11
5ltc4459.9RNASE3, EPX, CCL11, IL5, IL13
6ovomucoid459.9IL5, IL4, IL13, IGHE
7rolipram45 61 3011.8CCL11, IL4, IL5, IL13, EPX
8praziquantel45 1310.8RNASE3, IL13, IL5, IL4, IGHE
9salmeterol45 51 30 1312.8RNASE3, EPX, CCL11, IL4, IL5, IL13
10il 10459.8IL13, IL4R, IL5, IL4, CCL17
11anti-histamine459.8RNASE3, IGHE, CCL11, HRH1
12levocetirizine459.7HRH1, IL4, CCL11
13theophylline45 30 26 1312.7IL5, IL13, NGF, EPX, RNASE3
14desloratadine45 1310.7IGHE, HRH1, IL13, IL4
15ltd4459.7IL5, HRH1, IL13, RNASE3
16salbutamol45 51 30 26 1313.7EPX, CCL11, IL5, RNASE3, IGHE, IL13
17pgd2459.7IL5, IL13, EPX, IGHE, RNASE3, CCL11
18montelukast45 51 30 1312.7CCL11, IL4, IL5, IL13, IGHE, RNASE3
19fluticasone propionate45 51 61 1312.6IGHE, IL5, RNASE3, CCL11, IL4, IL13
20nedocromil sodium459.6IL4, RNASE3, IL5, HRH1, IGHE
21azelastine45 1310.6RNASE3, IL4, IL5, HRH1, IGHE
22sodium cromoglycate459.5EPX, CCL11, IL5, HRH1, RNASE3, IGHE
23cetirizine45 30 26 1312.5IGHE, EPX, RNASE3, CCL11, IL5, HRH1
24prednisolone45 30 1311.5NGF, CCL11, IL5, IL13, EPX, RNASE3
25budesonide45 51 1311.5IGHE, RNASE3, EPX, CCL11, IL4, IL5
26leukotriene b445 61 2611.5IL5, CCL11, EPX, RNASE3, IL13
27ionomycin459.5CCL11, IL4, IL5, IL17A, IL4R, IL9
28ketotifen45 1310.5IGHE, RNASE3, CCL11, IL5, HRH1, EPX
29ccl445 3010.5CCL17, IL13, CCR8, CCL11, IL17A
30capsaicin45 3010.4IGHE, HRH1, RNASE3, IL5, NGF
31ccl345 3010.4IL13, CCL11, CCL24, CCL17, CCR8
32aspirin45 51 30 2612.2CCL11, IL13, RNASE3, HRH1, NGF, IGES
33tacrolimus45 51 1311.2CCL11, CCL17, IL5, IL13, HRH1, IL4
34pge2459.1IL17A, RNASE3, EPX, HRH1, IL13, CCL11
35actinomycin d459.0NGF, CCL24, CCL11, IL13, IL4R, IL17A
36sb 20358045 6110.0NGF, IL13, IL5, IL4, CCL11, IL17A
37indomethacin45 30 61 1312.0IGHE, NGF, CCL11, IL4, IL5, IL17A
38thymidine45 269.9IL4R, IL9, IL13, HRH1, NGF, IL17A
39methacholine45 51 1310.9IL13, IL9, IL17A, IL5, IL4, CCL11
40vegf458.9IGHE, IL13, IL17A, IL5, NGF, RNASE3
41adenylate458.8HRH1, IL13, IL5, IL4, RNASE3, NGF
42steroid458.8CCL24, IL13, IL4R, IL17A, CCL13, EPX
43nitric oxide45 26 1310.6HRH1, IL13, IL9, IL17A, CCL11, IGES
44tyrosine458.5IL13, IL9, IL4R, IL17A, IL5, IL4
45tarc458.2CCL17, IGHE, CCL13, CCR8, IL5, IL4R
46cyclosporin a45 30 6110.2IGES, IGHE, HRH1, IL13, IL4R, IL17A
47allergens458.1IGHE, RNASE3, EPX, CCL17, CCL11, IGES
48dexamethasone45 51 30 1311.0CCL17, IL4R, HRH1, CCL13, IL17A, EPX
49rantes457.8HRH1, IL13, IL9, IL4R, IL17A, IL5
50histamine45 30 269.7IGES, IGHE, HRH1, IL13, IL9, IL4R

GO Terms for genes affiliated with Allergic Rhinitis

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Cellular components related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.0IGHE, NGF, RNASE3, CCL17, CCL11, IL5
2extracellular spaceGO:00056157.8NGF, CCL17, CCL24, CCL11, CCL13, IL4

Biological processes related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage activationGO:004303210.3IL4R, IL13
2regulation of proton transportGO:001015510.3IL13, IL4
3defense response to protozoanGO:004283210.1IL4R, IL4
4positive regulation of B cell proliferationGO:003089010.1IL13, IL5, IL4
5positive regulation of sequence-specific DNA binding transcription factor activityGO:005109110.1NGF, IL4, IL5
6response to radiationGO:000931410.0CCL11, NGF
7positive regulation of Rac GTPase activityGO:003285510.0CCL24, CCL11
8cytoskeleton organizationGO:00070109.9CCL13, CCL11, CCL24
9regulation of cell shapeGO:00083609.9CCL13, CCL24, CCL11
10response to nicotineGO:00350949.8NGF, IL13
11eosinophil chemotaxisGO:00482459.7HRH1, CCL13, CCL11, CCL24
12cell-cell signalingGO:00072679.5IL17A, CCL17, CCL24, CCL13, IL13
13signal transductionGO:00071659.4CCL24, CCL13, IL4R, CCL11, IL13
14chemotaxisGO:00069359.2IL4, CCL17, CCL24, CCL11, CCR8, CCL13
15inflammatory responseGO:00069548.4NGF, CCL17, CCL24, CCL11, IL5, HRH1
16immune responseGO:00069557.9IGHE, CCL17, IL9, IL4R, IL17A, IL5

Molecular functions related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.7IL9, IL5, IL4, NGF
2chemokine activityGO:00080099.4CCL11, CCL17, CCL24, CCL13
3cytokine activityGO:00051259.1IL13, IL4, IL5, IL17A, IL9

Products for genes affiliated with Allergic Rhinitis

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Sources for Allergic Rhinitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet