MCID: ALL003
MIFTS: 66

Allergic Rhinitis malady

Respiratory diseases, Immune diseases categories

Summaries for Allergic Rhinitis

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Each spring, summer, and fall, trees, weeds, and grasses release tiny pollen grains into the air. some of the pollen ends up in your nose and throat. this can trigger a type of allergy called hay fever. symptoms can include sneezing, often with a runny or clogged nose coughing and postnasal drip itching eyes, nose and throat red and watery eyes dark circles under the eyes your health care provider may diagnose hay fever based on a physical exam and your symptoms. sometimes skin or blood tests are used. taking medicines and using nasal sprays can relieve symptoms. you can also rinse out your nose, but be sure to use distilled or sterilized water with saline. allergy shots can help make you less sensitive to pollen and provide long-term relief. nih: national institute of allergy and infectious diseases

MalaCards: Allergic Rhinitis, also known as hay fever, is related to rhinitis and allergic asthma. An important gene associated with Allergic Rhinitis is IL13 (interleukin 13), and among its related pathways are PAK Pathway and Rho Family GTPases. The compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

Wikipedia:63 Allergic rhinitis is an allergic inflammation of the nasal airways. It occurs when an allergen, such as... more...

Description from OMIM:46 607154

Aliases & Classifications for Allergic Rhinitis

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8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Aliases & Descriptions:

allergic rhinitis 8 46 10 44 60
hay fever 8 33 60
allergic rhinitis due to animal hair and dander 8
allergic rhinitis, susceptibility to 9
allergic rhinitis due to pollen 8
non-seasonal allergic rhinitis 8
allergic rhinitis due to food 8
seasonal allergic rhinitis 8
perenial allergic rhinitis 8
rhinitis allergic seasonal 44
hay fever - pollens 8
allergy to pollen 8
atopic rhinitis 8
pollenosis 8
pollinosis 8


External Ids:

Disease Ontology8 DOID:4481
NCIt39 C34987
SNOMED-CT56 38103000
OMIM46 607154
ICD1025 J30.1

Related Diseases for Allergic Rhinitis

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17GeneCards, 18GeneDecks
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Diseases related to Allergic Rhinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1rhinitis32.4CCL11, SCGB1A1, IGHE, EPX, RNASE3, IL13
2allergic asthma31.7EPX, RNASE3, IL13, IL5, IL9, IL4R
3asthma31.7IL13, SCGB1A1, CCL11
4chronic rhinitis31.2RNASE3, HRH1
5eosinophilia30.9CCL24, CCL11, CCL13, CCR3, IGHE, NGF
6allergic conjunctivitis30.9CCL11, IGHE, RNASE3, IL13, IL5, IL4
7conjunctivitis30.8HRH1, RNASE3, IGHE
8urticaria30.8IGHE, RNASE3, HRH1
9otitis media30.6CCL11, IGHE, RNASE3
10common cold30.5CCL11, RNASE3
11atopic dermatitis30.5CCL11, HRH1, IL4, IL13, RNASE3, NGF
12dermatitis30.5IL5, IL4, IL17A, IL13, IGHE, CCL11
13cystic fibrosis30.3SCGB1A1, RNASE3, CLC, IL9, IL17A
14allergic bronchopulmonary aspergillosis30.3IGHE, IL5, IL4
15giant papillary conjunctivitis30.1CCL11, RNASE3, IL5
16leukemia30.1CCL11, SCGB1A1, NGF, EPX, RNASE3, IL9
17food allergy30.1IL4, IL5, IL13, CCL11, IGHE, EPX
18keratoconjunctivitis30.1CCL11, RNASE3, IL13, IL5
19tuberculosis30.1EPX, IL4R, IL4, IL17A
20graves' disease30.1IL4, IL4R, IL13
21churg-strauss syndrome30.1IL5, RNASE3
22obesity30.1CCL11, IL17A
23allergic urticaria10.6
24vasomotor rhinitis10.5
25neuronitis10.3
26nasopharyngitis10.3
27adenoiditis10.3
28neurodermatitis10.2
29tonsillitis10.2
30aspergillosis10.2
31migraine10.2
32netherton syndrome10.1
33lung cancer10.1
34attention deficit hyperactivity disorder10.1
35pulmonary tuberculosis10.1
36multinodular goiter10.1
37common variable immunodeficiency10.1
38empty sella syndrome10.1
39chronic fatigue syndrome10.1
40klippel-feil syndrome10.1
41cough variant asthma10.1
42osteoporosis10.1
43cervicitis10.1
44goiter10.1
45herpes simplex10.1
46iridocyclitis10.1
47laryngitis10.1
48neonatal jaundice10.1
49sleep disorder10.1
50squamous cell carcinoma10.1

Graphical network of the top 20 diseases related to Allergic Rhinitis:



Diseases related to allergic rhinitis

Clinical Features for Allergic Rhinitis

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46OMIM
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Clinical features from OMIM:

607154

Drugs & Therapeutics for Allergic Rhinitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Allergic Rhinitis

Drug clinical trials:

Search ClinicalTrials for Allergic Rhinitis

Search NIH Clinical Center for Allergic Rhinitis

Search CenterWatch for Allergic Rhinitis

Genetic Tests for Allergic Rhinitis

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Anatomical Context for Allergic Rhinitis

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32MalaCards
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MalaCards organs/tissues related to Allergic Rhinitis:

32
Skin, Eye, Testes, T cells, Endothelial, B cells, Lung, Bone, Tonsil, Liver, Lymph node, Nk cells, Monocytes, Spleen, Thymus, Heart, Bone marrow

Animal Models for Allergic Rhinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Allergic Rhinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8CCR3, CCL11, CCL24, HRH1, HAVCR1, SCGB1A1
2MP:000539711.6IL17A, EPX, CCL24, CCL11, CCR3, HAVCR1
3MP:000538811.6CCL11, CCL24, IL17A, IL4, IL5, IL4R
4MP:000537611.2CCR3, SCGB1A1, IGHE, IL13, HRH1, IL17A
5MP:000538111.1FOXJ1, IL13, IL9, IL4R, IL4, IL17A

Publications for Allergic Rhinitis

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50PubMed
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Articles related to Allergic Rhinitis:

(show top 50)    (show all 1181)
idTitleAuthorsYear
1
Interleukin-4 receptor I+-chain polymorphisms and susceptibility to allergic rhinitis: a meta-analysis. (24337880)
2013
2
The link between parental allergy and offspring allergic and nonallergic rhinitis. (24117663)
2013
3
Ginsenoside Rg1 inhibits the TSLP production in allergic rhinitis mice. (24053327)
2013
4
Korean red ginseng for allergic rhinitis. (24067144)
2013
5
Effect of nebulized beclomethasone on airway inflammation and clinical status of children with allergic asthma and rhinitis: a randomized, double-blind, placebo-controlled study. (23257680)
2013
6
Severity assessment of Japanese cedar pollinosis using the practical guideline for the management of allergic rhinitis in Japan and the allergic rhinitis and its impact on asthma guideline. (23435559)
2013
7
The effects of mometasone furoate and desloratadine in obstructive sleep apnea syndrome patients with allergic rhinitis. (23883803)
2013
8
Survey on the prevalence of allergic rhinitis and its effect on the quality of high school students' life. (24303424)
2013
9
Increased expression of CD69 antigen on human peripheral blood natural killer cells in patients with allergic rhinitis. (23454781)
2013
10
Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis. (24332860)
2013
11
Assessment of disease control in allergic rhinitis. (23419058)
2013
12
Clinical usefulness of a guideline-based screening tool for the diagnosis of allergic rhinitis in asthmatics: the Self Assessment of Allergic Rhinitis and Asthma questionnaire. (23668782)
2013
13
Association between allergic rhinitis and asthma control in Peruvian school children: a cross-sectional study. (23984414)
2013
14
The association between allergic rhinitis and sleep-disordered breathing in children: a systematic review. (23307785)
2013
15
Obesity and the risk of chronic rhinosinusitis, allergic rhinitis, and acute otitis media in school-age children. (23918707)
2013
16
Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. (23253209)
2013
17
Effects of rhinophototherapy on quality of life in persistant allergic rhinitis. (23799163)
2013
18
The anti-inflammatory effects of acupuncture and their relevance to allergic rhinitis: a narrative review and proposed model. (23476696)
2013
19
The united allergic airway: connections between allergic rhinitis, asthma, and chronic sinusitis. (22643942)
2012
20
The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis. (22233535)
2012
21
Lack of efficacy of a herbal preparation (RCM-102) for seasonal allergic rhinitis: a double blind, randomised, placebo-controlled trial. (22872821)
2012
22
The role of worm infestation in allergic rhinitis. (23018498)
2012
23
Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. (22726593)
2012
24
Control of Allergic Rhinitis and Asthma Test (CARAT) can be used to assess individual patients over time. (22935298)
2012
25
Comparison of sensory attributes and immediate efficacy of intranasal ciclesonide and fluticasone propionate in allergic rhinitis: a randomized controlled trial. (23112411)
2012
26
To study of the nasal mucosa remodeling of allergic rhinitis patients]. (22667130)
2012
27
Serum and nasal lavage fluid Clara cell protein decreases in children with allergic rhinitis. (22704673)
2012
28
Association between allergic rhinitis and migraine. (23626624)
2012
29
Allergic rhinitis and non-allergic rhinitis in children in the tropics: prevalence and risk associations. (22628118)
2012
30
Effects of intranasal mometasone furoate on itchy ear and palate in patients with seasonal allergic rhinitis. (22541408)
2012
31
A preliminary study on the regulation mechanism of p38MAPK on MUC5AC in allergic rhinitis]. (22239058)
2011
32
Focusing into new challenges in allergic rhinitis and urticaria. Introduction. (22185043)
2011
33
Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis. (20422678)
2010
34
Identification of IgE-mediated food allergy and allergens in older children and adults with asthma and allergic rhinitis. (21302599)
2010
35
Sublingual immunotherapy affects specific antibody and TGF-beta serum levels in patients with allergic rhinitis. (20074473)
2009
36
The effect of local nasal immunotherapy in allergic rhinitis: using strips of the allergen dermatophagoides pteronyssinus. (19253124)
2009
37
Effects of recombinant eotaxin N terminal mutant (Met/Eotaxin) adenovirus on allergic rhinitis in mice]. (16759010)
2006
38
Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. (16146574)
2005
39
Association between polymorphisms of the angiotensin-converting enzyme and angiotensinogen genes and allergic rhinitis in a Korean population. (15112973)
2004
40
Increased eosinophil transmigration after nasal allergen challenge in children with allergic asthma and rhinitis. (12464051)
2002
41
Further improvement of quality of life by cetirizine in perennial allergic rhinitis as a function of treatment duration. (10879992)
2000
42
Airway inflammation in asthma and perennial allergic rhinitis. Relationship with nonspecific bronchial responsiveness and maximal airway narrowing. (10782520)
2000
43
Regulation of proinflammatory cytokines in seasonal allergic rhinitis. (10224452)
1999
44
Investigation of the efficacy and tolerability of azelastine nasal spray versus ebastine tablets in patients with seasonal allergic rhinitis]. (9585822)
1998
45
Effect of slow-release theophylline on nasal antigen challenge in subjects with allergic rhinitis. (9648963)
1998
46
Exudative hyperresponsiveness of the airway microcirculation in seasonal allergic rhinitis. (8556565)
1995
47
Heterogeneous eosinophils of allergic rhinitis in chemotactic response. (8155995)
1994
48
Pathophysiology of chronic allergic rhinitis]. (8090500)
1994
49
Allergic and vasomotor rhinitis in asthmatics in the tropics and subtropics. (2360127)
1990
50
Lack of suppression of IgE production by recombinant interferon gamma: a controlled trial in patients with allergic rhinitis. (2110199)
1990

Genetic Variations for Allergic Rhinitis

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Expression for genes affiliated with Allergic Rhinitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Rhinitis

Search GEO for disease gene expression data for Allergic Rhinitis.

Pathways for genes affiliated with Allergic Rhinitis

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.3CCL24, IL4, IL4R, IL9, IL5, IL13
2
Hide members
11.3CCL24, CCL11, CCL13, CCR3, IL13, IL5
3
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11.3IL4R, IL9, IL5, IL13, CCR3, CCL13
4
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11.2CCL11, EPX, RNASE3, IL13, IL5, IL9
5
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11.2CCL24, CCL11, CCL13, IL13, IL5, IL9
6
Hide members
11.2CCL24, CCL11, CCR3, IL13, IL5, IL9
7
Hide members
11.0CCL11, IGHE, IL13, IL5, IL4R, IL4
810.9IL4, IL4R, IL9, IL5, IL13
910.9IL13, IL5, IL9, IL4R, IL4
10
Hide members
10.9IL17A, IL4, IL4R, IL5, IL13
1110.9CCL11, IGHE, IL5, IL4R, IL4
1210.8IL13, IL5, IL9, IL4
1310.8IL13, IL5, IL9, IL4
14
Hide members
10.8IL5, IL9, IL4, IL17A
15
Immune response CCR3 signaling in eosinophils
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10.8CCR3, CCL13, CCL11, CCL24
16
Hide members
10.8CCL24, CCL11, CCL13, CCR3
1710.8IL4, IL5, IL13
1810.8CCL11, IL5, IL4
1910.8IL4, IL4R, IL5
2010.8IL5, IL4R, IL4
21
Hide members
10.8IL17A, IL4, IL4R

Compounds for genes affiliated with Allergic Rhinitis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2414.2IL5, CCL24, CCL11, CCL13, CCR3, IGHE
2dexamethasone44 49 28 1115.1CCL11, CCR3, IGHE, NGF, EPX, RNASE3
3tyrosine4411.9IL4R, HAVCR1, NGF, CCR3, CCL11, IL13
4allergens4411.8CCL11, HRH1, RNASE3, IL4, IGHE, EPX
5tarc4411.8IL9, CCL24, CCL11, IL4, IL4R, IL5
6cyclosporin a44 28 5913.8IL13, CCL11, IGHE, NGF, RNASE3, HRH1
7thymidine44 2412.8CCR3, CCL11, IL13, IL5, HRH1, NGF
8actinomycin d4411.7IL4R, NGF, IGHE, CCR3, CCL11, CCL24
9methacholine44 1112.7CCL11, IGHE, IL17A, IL4, IL9, RNASE3
10steroid4411.6IL4R, RNASE3, IL17A, EPX, CCL11, CCL13
11rantes4411.6CCL11, RNASE3, IL9, IL4R, IL4, IL17A
12budesonide44 49 1113.6IL5, IL13, RNASE3, IL4, IGHE, CCL11
13pgd24411.6IGHE, IL5, IL13, RNASE3, CCR3, CCL11
14prednisolone44 28 1113.5RNASE3, EPX, NGF, IGHE, CCL11, IL5
15ionomycin4411.5IL9, IL5, IL13, IL17A, IL4, CCL11
16adenylate4411.5IGHE, HRH1, IL4, IL5, IL13, RNASE3
17sodium cromoglycate4411.5EPX, CCL11, IGHE, HRH1, IL5, RNASE3
18cetirizine44 28 11 2414.5CCL11, HRH1, IL5, RNASE3, EPX, IGHE
19salmeterol44 49 28 1114.5EPX, CCL11, IL4, RNASE3, IL13, IL5
20montelukast44 49 28 1114.5IL4, IL5, IL13, IGHE, CCL11, RNASE3
21ketotifen44 1112.5HRH1, RNASE3, EPX, IGHE, CCL11, IL5
22salbutamol44 49 28 11 2415.4CCL11, IGHE, EPX, RNASE3, IL13, IL5
23fluticasone propionate44 49 59 1114.4CCL11, IGHE, RNASE3, IL13, IL4, IL5
24nedocromil sodium4411.3IL5, HRH1, IL4, RNASE3, IGHE
25praziquantel44 1112.3IL13, IL4, IL5, IGHE, RNASE3
26azelastine44 1112.3IL5, RNASE3, IGHE, HRH1, IL4
27ltd44411.3HRH1, IL5, IL13, RNASE3, CCR3
28ltc44411.3CCL11, EPX, IL5, IL13, RNASE3
29vegf4411.3IL4, IGHE, IL13, IL5, NGF, IL17A
30tacrolimus44 49 1113.2CCL11, IL13, IL17A, IL4, IL5, HRH1
31unicap4411.2IL5, IGHE, CCL11, RNASE3
32omalizumab44 1112.2IL5, IGHE, IL13, IL4
33capsaicin44 2812.2RNASE3, NGF, IGHE, IL5, HRH1
34anti-histamine4411.2CCL11, IGHE, RNASE3, HRH1
35lte44411.2CCL11, IL5, EPX, RNASE3
36aspirin44 49 28 2414.2HRH1, CCL11, IL13, IL4, RNASE3, NGF
37desloratadine44 1112.2IL4, HRH1, IL13, IGHE
38theophylline44 28 11 2414.2IL13, IL5, EPX, RNASE3, NGF
39indomethacin44 59 28 1114.1NGF, IL5, HRH1
40pranlukast44 28 1113.1CCL11, RNASE3, IL5, IL4
41leukotriene b444 59 2413.1IL5, IL13, RNASE3, EPX, CCL11
42sb 20358044 5912.0IL13, IL5, IL4, IL17A, CCL11, NGF
43endotoxin4411.0RNASE3, HRH1, SCGB1A1
44pge24411.0EPX, CCL11
45levocetirizine4410.9CCL11, IL4, HRH1
46ovomucoid4410.9IGHE
47rolipram44 59 2812.9EPX
48creatinine4410.8NGF, RNASE3, IGHE, HRH1, EPX, SCGB1A1
49oxatomide4410.8HRH1, IGHE, IL5
50levocabastine44 28 1112.7RNASE3, IL5, HRH1

GO Terms for genes affiliated with Allergic Rhinitis

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16Gene Ontology
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Cellular components related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.6IL17A, CCL11, CCL13, CCR3, SCGB1A1, NGF

Biological processes related to Allergic Rhinitis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.7HRH1, CCL24, CCL11, CCL13, CCR3, NGF
2immune responseGO:00695511.7CCL24, CCL11, CCL13, IGHE, IL13, IL5
3eosinophil chemotaxisGO:04824511.2CCL24, CCL11, CCL13, CCR3, HRH1
4chemotaxisGO:00693511.2CCL24, CCL11, CCL13, CCR3, IL4
5signal transductionGO:00716511.1CCL24, CCL11, CCL13, SCGB1A1, IL13, IL4R
6positive regulation of B cell proliferationGO:03089011.0IL4, IL5, IL13
7cell-cell signalingGO:00726711.0CCL24, CCL13, IL13, IL17A
8positive regulation of endothelial cell proliferationGO:00193811.0CCR3, CCL11, CCL24
9response to ozoneGO:01019310.9SCGB1A1, NGF
10positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.9IL4, IL5, NGF
11negative regulation of interleukin-5 productionGO:03271410.9SCGB1A1, EPX
12regulation of proton transportGO:01015510.9IL13, IL4
13mast cell chemotaxisGO:00255110.9CCL11, CCR3
14positive regulation of angiogenesisGO:04576610.8CCR3, CCL11, CCL24
15positive regulation of macrophage activationGO:04303210.8IL13, IL4R
16response to lipopolysaccharideGO:03249610.8IL13, NGF, SCGB1A1
17cytoskeleton organizationGO:00701010.8CCL24, CCL11, CCL13
18regulation of cell shapeGO:00836010.7CCL13, CCL11, CCL24
19defense response to protozoanGO:04283210.4IL4, IL4R

Molecular functions related to Allergic Rhinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.8IL17A, IL4, IL9, IL5, IL13
2chemokine activityGO:00800910.8CCL13, CCL11, CCL24
3growth factor activityGO:00808310.5NGF, IL5, IL9, IL4

Products for genes affiliated with Allergic Rhinitis

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  • Antibodies
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Sources for Allergic Rhinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet