MCID: ALP008
MIFTS: 57

Alopecia malady

Genetic diseases (common) category
Download this MalaCard

Summaries for Alopecia

About this section


Fully expand this MalaCard
Wikipedia:65 Hair loss or baldness (technically known as alopecia) is a loss of hair from the head or body. Baldness... more...

MalaCards based summary: Alopecia is related to alopecia universalis and androgenetic alopecia, and has symptoms including An important gene associated with Alopecia is HR (hair growth associated), and among its related pathways are Th17 Differentiation and Downstream signaling in naive CD8+ T cells. The compounds alpha-galactosylceramide and 17-hydroxypregnenolone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are integument and tumorigenesis.

Disease Ontology:8 A hypotrichosis that is characterized by a loss of hair from the head or body.

Descriptions from OMIM:46 300042,109200

Aliases & Classifications for Alopecia

About this section

Alopecia, Aliases & Descriptions:

Name: Alopecia 30 8 20 22 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

Disease Ontology8 DOID:987
ICD9CM27 704.00, 704.0
NCIt39 C50575
MeSH34 D000505

Related Diseases for Alopecia

About this section

Diseases related to Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 494)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia universalis32.1HR
2androgenetic alopecia31.8SHBG, CYP21A2
3alopecia areata31.7AIRE, IFNG, GZMB
4acne30.9SHBG
5myasthenia gravis30.5IFNG, AIRE
6candidiasis30.5IFNG, AIRE
7hypothyroidism30.5SHBG, AIRE
8hypogonadism30.4SHBG
9hyperandrogenism30.2CYP21A2, SHBG
10turner syndrome30.0SHBG, CYP21A2
11polycystic ovary syndrome30.0SHBG, CYP21A2
12autoimmune thyroiditis30.0AIRE, CYP21A2, IFNG
13male infertility29.8SHBG, CYP21A2
14aplastic anemia29.7IFNG, GZMB
15cutaneous t cell lymphoma29.6GZMB, IFNG
16graves' disease29.6AIRE, CYP21A2, SHBG, IFNG
17graft versus host disease29.6GZMB, IFNG
18celiac disease29.4CYP21A2, GZMB
19alopecia totalis10.8
20frontal fibrosing alopecia10.7
21androgenic alopecia10.6
22central centrifugal cicatricial alopecia10.5
23vitiligo10.5
24psoriasis10.5
25lupus erythematosus10.4
26telogen effluvium10.4
27t-cell immunodeficiency, congenital alopecia and nail dystrophy10.4
28follicular mucinosis10.4
29trichotillomania10.4
30dermatitis10.4
31lichen planus10.4
32thyroiditis10.4
33discoid lupus erythematosus10.4
34rickets10.3
35hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
36diffuse alopecia areata10.3
37prostatitis10.3
38blindness10.3
39folliculitis10.3
40ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.3
41rasmussen encephalitis10.3GZMB
42alopecia-intellectual disability syndrome10.3
43hepatitis10.2
44tinea capitis10.2
45congenital alopecia x-linked10.2
46thumb deformity, alopecia, pigmentation anomaly10.2
47autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.2CYP21A2, AIRE
48prostate cancer10.2
49cronkhite-canada syndrome10.2
50syphilis10.2

Graphical network of the top 20 diseases related to Alopecia:



Diseases related to alopecia

Symptoms for Alopecia

About this section


Clinical features from OMIM:

300042,109200

HPO human phenotypes related to Alopecia:

id Description Frequency HPO Source Accession
1 abnormality of the eye hallmark (90%) HP:0000478
2 abnormality of the skin hallmark (90%) HP:0000951
3 alopecia hallmark (90%) HP:0001596
4 aplasia/hypoplasia of the eyebrow hallmark (90%) HP:0100840

Drugs & Therapeutics for Alopecia

About this section

Drug clinical trials:

Search ClinicalTrials for Alopecia

Search NIH Clinical Center for Alopecia

Genetic Tests for Alopecia

About this section

Genetic tests related to Alopecia:

id Genetic test Affiliating Genes
1 Alopecia20 22

Anatomical Context for Alopecia

About this section

MalaCards organs/tissues related to Alopecia:

32
Skin, T cells, Thyroid, Prostate, Breast, Testes, Bone, Pituitary, Heart, Endothelial, Bone marrow, Ovary, Liver, Lung, Monocytes, Tongue, Eye, Thymus, Colon, Nk cells, B cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alopecia:
id TissueAnatomical CompartmentCell Relevance
1 HairHair FollicleFetal Hair Placode Cells Affected by disease
2 HairHair FollicleFetal Matrix Cells Affected by disease
3 DermisDermal PapillaGuard Dermal Papilla Cells Affected by disease
4 HairHair FolliclePrimary Hair Placode Cells Affected by disease

Animal Models for Alopecia or affiliated genes

About this section

MGI Mouse Phenotypes related to Alopecia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.1ALX4, HR, FOXN1, CLDN1, IFNG
2MP:00020068.8AIRE, FOXN1, IFNG, GZMB, HR
3MP:00053918.8HR, AIRE, FOXN1, IFNG, ALX4

Publications for Alopecia

About this section

Articles related to Alopecia:

(show top 50)    (show all 1682)
idTitleAuthorsYear
1
A study on the extracts of Cuscuta reflexa Roxb. in treatment of cyclophosphamide induced alopecia. (24393240)
2014
2
The Association of Lacrimal Gland Inflammation with Alopecia Areata. (25280049)
2014
3
Trichostasis spinulosa of the scalp mimicking Alopecia areata black dots. (25054768)
2014
4
Congenital triangular alopecia. (24403390)
2014
5
Is more hair always better? A single biopsy specimen is preferred for the evaluation of alopecia. (24117846)
2014
6
Scarring Alopecia in Classic Adult Type I Pityriasis Rubra Pilaris. (25015636)
2014
7
The Autoimmune Basis of Alopecia Areata: A Comprehensive Review. (25315746)
2014
8
Frontal fibrosing alopecia. (25128114)
2014
9
Genetic analysis of interleukin-1 receptor antagonist and interleukin-1I^ single-nucleotide polymorphisms C-511T and C+3953T in alopecia areata: susceptibility and severity association. (23584371)
2013
10
Female pattern alopecia: current perspectives. (24039457)
2013
11
Alopecia areata associated with Herpes zoster. (23682830)
2013
12
Therapy for alopecia areata in mice using parathyroid hormone agonists and antagonists, linked to a collagen-binding domain. (24326563)
2013
13
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. (24019775)
2013
14
Alopecia areata - Vitiligo overlap syndrome: an emerging clinical variant. (23760330)
2013
15
Summary of the Preceding Three Alopecia Areata Research Summits: What's Past Is Prologue. (24326556)
2013
16
Diffuse neurofibroma - an uncommon cause of alopecia. (24346909)
2013
17
Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship? (23329992)
2012
18
The follicular triad: a pathological clue to the diagnosis of early frontal fibrosing alopecia. (21787366)
2012
19
General practitioners' knowledge and practices related to alopecia areata in Qassim region, Saudi Arabia. (22415332)
2012
20
Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. (22763785)
2012
21
Temporary alopecia after embolization of an arteriovenous malformation. (23031381)
2012
22
Association between scalp psoriasis and alopecia areata. (22535354)
2012
23
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. (21272494)
2011
24
Investigative guidelines for alopecia areata. (21689240)
2011
25
Hair grooming practices and central centrifugal cicatricial alopecia. (19293007)
2009
26
Is Helicobacter pylori infection associated with alopecia areata? (19250167)
2009
27
Treatment of alopecia areata in children. (19685659)
2009
28
Compound heterozygous mutations in the vitamin D receptor in a patient with hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia. (19049339)
2009
29
Treatment of postmenopausal frontal fibrosing alopecia with oral dutasteride. (19539860)
2009
30
Alopecia areata is not associated with Helicobacter pylori. (20049262)
2009
31
Lack of efficacy of topical imiquimod in the treatment of patchy alopecia areata. (18986369)
2008
32
Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample. (18986440)
2008
33
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. (16914743)
2006
34
The alopecias associated with vitamin D-dependent rickets type IIA and with hairless gene mutations: a comparative clinical, histologic, and immunohistochemical study. (15781675)
2005
35
Androgenetic alopecia and current methods of treatment. (15818439)
2005
36
Association of a polymorphism in the ornithine decarboxylase gene with male androgenetic alopecia. (15761444)
2005
37
Vitamin D-dependent rickets Type II with alopecia: two case reports and review of the literature. (12956677)
2003
38
Androgenetic alopecia in men aged 40-69 years: prevalence and risk factors. (14674898)
2003
39
A mosaic pattern of alopecia in the oral-facial-digital syndrome type I (Papillon-LAcage and psaume syndrome). (10571835)
1999
40
Equine alopecia areata autoantibodies target multiple hair follicle antigens and may alter hair growth. A preliminary study. (9832317)
1998
41
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
42
Growth retardation, alopecia, pseudoanodontia, and optic atrophy (GAPO syndrome) with congenital glaucoma. (9230846)
1997
43
Alopecia universalis in liver transplant patients treated with cyclosporin. (7577610)
1995
44
Alopecia universalis as a single abnormality in an inbred Pakistani kindred. (8357006)
1993
45
Hormonal status in postmenopausal androgenetic alopecia. (1478763)
1992
46
Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice. (1536782)
1992
47
Alopecia in meralgia paresthetica. (3973115)
1985
48
Spontaneous cell-mediated cytotoxicity (SCMC) in patients with alopecia universalis. (6172934)
1981
49
Hyperkeratotic follicular plugging with alopecia totalis. (13774268)
1961
50
Alopecia totalis associated with onychodystrophy. (21065789)
1946

Variations for Alopecia

About this section

Expression for genes affiliated with Alopecia

About this section
Expression patterns in normal tissues for genes affiliated with Alopecia

Search GEO for disease gene expression data for Alopecia.

Pathways for genes affiliated with Alopecia

About this section

Pathways related to Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GZMB, IFNG
2
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.7GZMB, IFNG
3
Show member pathways
9.7GZMB, IFNG

Compounds for genes affiliated with Alopecia

About this section

Compounds related to Alopecia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide4410.0IFNG, GZMB
217-hydroxypregnenolone4410.0SHBG, CYP21A2
311 deoxycortisol4410.0SHBG, CYP21A2
4leuprolide acetate449.9SHBG, CYP21A2
5clomiphene citrate449.9CYP21A2, SHBG
63-alpha-androstanediol glucuronide44 2410.9CYP21A2, SHBG
7concanamycin a44 6110.9IFNG, GZMB
817-hydroxyprogesterone44 2410.9CYP21A2, SHBG
9spironolactone44 61 28 50 1113.8CYP21A2, SHBG
10ivig449.7IFNG, GZMB
11dehydroepiandrosterone sulfate449.7CYP21A2, SHBG
12hydrocortisone44 2 61 1112.7IFNG, SHBG, CYP21A2
13ketoconazole44 28 24 1112.6SHBG, CYP21A2
14phenytoin44 50 28 1112.4CYP21A2, SHBG
15prednisolone44 28 1111.2GZMB, IFNG, SHBG, CYP21A2
16dexamethasone44 50 28 1112.0IFNG, SHBG, GZMB, CYP21A2
17arginine449.0GZMB, SHBG, CYP21A2, IFNG

GO Terms for genes affiliated with Alopecia

About this section

Biological processes related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1humoral immune responseGO:0069599.9IFNG, AIRE
2hair follicle developmentGO:0019429.7ALX4, FOXN1

Products for genes affiliated with Alopecia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Alopecia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet