Alopecia malady

Wikipedia: Alopecia (pron.: /ˌæləˈpiːʃə/, from Classical Greek ἀλώπηξ, alōpēx) means loss of hair...⁴⁴ more...

MalaCards: Alopecia is related to alopecia areata and androgenetic alopecia. An important gene associated with Alopecia is HR (hairless homolog (mouse)), and among its related pathways are Immune System and Rheumatoid arthritis. The compounds ly294002 and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and lung, and related mouse phenotypes are integument and behavior/neurological.

Aliases & Descriptions:

alopecia 6 16 8

Diseases related to alopecia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1087)

id	Related Disease	Score	Top Affiliating Genes
1	alopecia areata	38.0	VDR, BIRC5, ULBP3, CIITA, MX1, XDH
2	androgenetic alopecia	36.1	XIAP, CFLAR, AR, CYP19A1, CYP21A2, SRD5A1
3	alopecia universalis	34.2	WDR11, LIPH, INS, FAIM2, IFNG, HR
4	rickets	30.3	NCOA1, VDR, MED1, MED4, IGF1, CYP27B1
5	atopic dermatitis	29.5	KITLG, CD40, FLG, MIF, FCGR1A, IL10
6	hypogonadism	29.1	WDR11, RBM28, VDR, LMNA, FOXN1, AR
7	ichthyosis	29.0	CLDN1, FLG, MBTPS2, CYP4F22, KRT16, KRT86
8	down syndrome	28.2	KITLG, MX1, XDH, CD79A, INS, IL10
9	omenn syndrome	28.2	IL10, IL1RN, IL4, IFNG, AIRE, TNF
10	folliculitis	28.1	IL2RA, IL4, MBTPS2, CCL11, CCL5, IFNG
11	lepromatous leprosy	28.0	IL10, IL2, IL4, IFNG
12	polycystic ovary syndrome	28.0	AR, INS, IGF1, CYP19A1, CYP21A2, SRD5A1
13	hypothyroidism	27.9	IL1A, AIRE, TPO, SHBG, NKX2-1
14	diabetes mellitus	27.8	BTD, VDR, LMNA, CIITA, XDH, T
15	atopy	27.8	KITLG, VDR, CIITA, CD79A, FLG, MIF
16	ulcerative colitis	27.8	CD79A, GZMB, MIF, IL10, IL16, IL1A
17	hyperprolactinemia	27.8	INS, IL4, IGF1, IFNG, SRD5A1, SHBG
18	cadasil	27.7	CIITA, CD40, APOB, CCL4, F8, HLA-B
19	immunodeficiency	27.5	CIITA, CFLAR, CD79A, CD4, CD40, GZMB
20	congenital ichthyosiform erythroderma	27.5	FLG, CYP4F22, KRT10, ABCA12, TGM1, STS
21	hyperandrogenism	27.1	LMNA, AR, INS, APOB, IGF1, TNF
22	diabetic ketoacidosis	27.0	BTD, INS, IL10, ICAM1, HLA-DQB1, HLA-DRB1
23	coronary heart disease	26.9	LMNA, XDH, CD79A, CDKN2A, MIF, INS
24	insulin resistance	26.3	VDR, LMNA, CD40, MIF, AR, INS
25	nevus	25.9	KIT, CLEC2A, MUC1, CDKN2A, CD34, FOXN1
26	severe combined immunodeficiency	25.1	KITLG, CIITA, CD4, CD34, CD40, FOXN1
27	combined immunodeficiency	25.1	KITLG, CIITA, CD4, CD34, CD40, FOXN1
28	dermatitis	24.0	KITLG, BTD, CLDN1, CIITA, MX1, MUC1
29	thyroiditis	23.5	NCOA1, KIT, KITLG, VDR, BIRC5, CLDN1
30	hypertension	23.2	KIT, VDR, LMNA, BIRC5, CIITA, MUC1
31	fibrosis	21.9	KIT, KITLG, BTD, VDR, LMNA, BIRC5
32	melanoma	21.0	KIT, KITLG, VDR, LMNA, BIRC5, CLDN1
33	prostatitis	20.5	NCOA1, KIT, KITLG, LPP, VDR, LMNA
34	virilization	14.4	AR, INS, MC2R, CYP19A1, CYP21A2, SRD5A1
35	myasthenia gravis	14.4	CIITA, CD79A, GZMB, AR, INS, IL10
36	congenital myasthenic syndrome	14.4	CIITA, CD79A, GZMB, AR, INS, IL10
37	subacute thyroiditis	14.4	IL1B, IL1R1, IL1RN, IL2RA, IFNG, ICAM1
38	androgen insensitivity syndrome	14.3	AR, INS, CYP19A1, SRD5A1, SRD5A2, SHBG
39	narcolepsy	14.3	CIITA, INS, IL1A, IL1RN, CCL2, HLA-DQA1
40	cerebral malaria	14.3	MIF, IL10, IL1A, IL1B, IL1R1, IL1RN
41	polymyositis	14.3	CD40, GZMB, MICA, IL1A, IL1RN, IL2RA
42	transsexualism	14.3	VDR, AR, CYP19A1, CYP21A2, SRD5A2, SHBG
43	juvenile rheumatoid arthritis	14.3	IL1A, IL1R1, IL1RN, IL2RA, HLA-DQA1, HLA-DQB1
44	neuritis	14.3	CIITA, MIF, INS, IL10, IL1B, IL2RA
45	periodic fever	14.3	XIAP, MIF, IL1B, IL1R1, IL1RN, IFNG
46	pseudohermaphroditism	14.3	AR, CYP19A1, CYP21A2, SRD5A1, SRD5A2, PRL
47	androgen insensitivity syndrome, partial	14.3	AR, CYP19A1, SRD5A1, SHBG
48	q fever	14.2	VDR, CD79A, IL10, IL1B, IL1R1, IL1RN
49	hepatitis c	14.2	CIITA, MX1, IL10, IL2, IL4, FAS
50	osteolysis	14.2	IL10, IL1A, IL1B, IL1R1, IL1RN, IL2

Approved drugs:

Drug clinical trials:

Genetic tests related to alopecia:

id	Genetic test	Affiliating Genes
1	Alopecia clinical/research

MalaCards organs/tissues related to alopecia:

²²

MGI Mouse Phenotypes related to alopecia:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	INF	ABCA12, DSP, TGM1, PRL, CSF3, POMC
2	behavior/neurological phenotype	MP:0005386	INF	NR3C2, PPARG, CTNNB1, CYP19A1, PTCH1, TNFRSF1A
3	endocrine/exocrine gland phenotype	MP:0005379	10.4	NCOA1, XDH, FOXN1, MED1, IL2, MC2R
4	limbs/digits/tail phenotype	MP:0005371	9.2	TP63, TNFRSF1A, TMPO, PTCH1, CTNNB1, KRT10
5	no phenotypic analysis	MP:0003012	8.7	TXNRD2, CTNNB1, PPARG, CRISP1, EGFR, POMC
6	hearing/vestibular/ear phenotype	MP:0005377	8.6	CTNNB1, PPARG, NOTCH3, KRT10, EGFR, TGFB2
7	vision/eye phenotype	MP:0005391	8.1	PTCH1, TNFRSF1A, TNF, TP63, AIRE, HOXC13
8	muscle phenotype	MP:0005369	7.7	CTNNB1, CYP19A1, PTCH2, PTCH1, TNFRSF1A, TNF
9	reproductive system phenotype	MP:0005389	INF	NCOA1, SRD5A2, CRISP1, NOTCH3, COL17A1, KRT14
10	tumorigenesis	MP:0002006	INF	FOXN1, GZMB, MIF, AR, IL10, IL1A
11	adipose tissue phenotype	MP:0005375	INF	TNFRSF1A, CYP19A1, PPARG, NOS3, EGFR, TGFB1
12	skeleton phenotype	MP:0005390	INF	NCOA1, KIT, KITLG, VDR, LMNA,
13	homeostasis/metabolism phenotype	MP:0005376	INF	IL1RN, TP63, TPO, TNFRSF1A, PTPN22, CYP19A1
14	mortality/aging	MP:0010768	INF	FOXN1, GZMB, FLG, AR, IL1B, IL1R1
15	embryogenesis phenotype	MP:0005380	INF	CTNNB1, NOTCH4, EGFR, DSP, TGFB2, PRL
16	immune system phenotype	MP:0005387	INF	NCOA1, IFNG, F8, HR, AIRE, HLA-C
17	liver/biliary system phenotype	MP:0005370	INF	MED1, IL1R1, IL2, APOA1, APOB, IKBKG
18	cellular phenotype	MP:0005384	INF	TXNRD2, TGFB2, DCLRE1C, PSIP1, SOD1, POMC
19	pigmentation phenotype	MP:0001186	INF	CCL2, IKBKG, PTCH1, CYP19A1, CTLA4, CTNNB1
20	cardiovascular system phenotype	MP:0005385	INF	IL1B, IL1R1, IL1RN, IL2, IL36RN, FBLN5
21	nervous system phenotype	MP:0003631	INF	NOTCH4, CYP19A1, PTCH2, PTCH1, TNFRSF1A, TXNRD2
22	normal phenotype	MP:0002873	INF	PTCH1, TNFSF13, TP63, TXNRD2, HLA-DQB1, AIRE
23	craniofacial phenotype	MP:0005382	INF	PTCH1, KRT16, KRT10, ABCA12, PSIP1, SLC39A4
24	renal/urinary system phenotype	MP:0005367	INF	PTCH1, CYP27B1, CTNNB1, NR3C2, NOS3, NOTCH3
25	digestive/alimentary phenotype	MP:0005381	INF	TP63, TMPO, PTCH1, PTCH2, CTLA4, CTNNB1
26	respiratory system phenotype	MP:0005388	INF	C5, ELN, ABCA12, NOTCH3, PTPN22, TP63
27	growth/size phenotype	MP:0005378	INF	MED1, COL17A1, PDPN, KRT16, KRT10, EGFR
28	hematopoietic system phenotype	MP:0005397	INF	KIT, XIAP, CFLAR, , CD34, CD200

Articles related to alopecia:

(show top 50)    (show all 163)

id	Title	Authors	Year	Affiliating Genes
1	Serum Interleukin-4 and Total Immunoglobulin E in Non atopic Alopecia Areata Patients and HLA-DRB1 Typing. (20671941)	Attia E.A.... Sefin A.	2010	HLA-DRB1
2	Serum T helper 1 cytokine levels are greater in patie nts with alopecia areata regardless of severity or atopy. (19874320)	Barahmani N.... Duvic M.	2010	IFNG
3	Fine mapping of the human AR/EDA2R locus in androgene tic alopecia. (20199557)	Brockschmidt F.F.... NAPthen M.M.	2010	AR, EDA2R
4	Changes of metabolic profile in men treated for andro genetic alopecia with 1 mg finasteride. (20151762)	Duskova M.... Starka L.	2010	INS
5	Melanocortin receptor type 2 (MC2R, ACTH receptor) ex pression in patients with alopecia areata. (20590821)	Guo H.W.... Hao F.	2010	MC2R
6	Trichohyalin is a potential major autoantigen in huma n alopecia areata. (20722389)	Leung M.C.... Tobin D.J.	2010	KRT16, TCHH
7	Ichthyosis follicularis, alopecia, and photophobia (I FAP) syndrome due to mutation of the gene MBTPS2 in a large Australian kindred. (19689518)	Ming A.... Fischer G.	2009	MBTPS2
8	Trichomegaly in a 3-year-old girl with alopecia areata. (19419469)	Nazareth M.R.... Rothman I.L.	2009	EGFR
9	Alopecia: association with resistance to thyroid horm ones. (20101894)	Guran T.... Bereket A.	2009	TXNRD2, HR
10	Diabetic ketoacidosis, thyroiditis and alopecia areat a in a child with Down syndrome. (20012788)	Pirgon O.... Sert A.	2009	TPO
11	Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome. (19026396)	Alazami A.M.... Alkuraya F.S.	2008	DCAF17
12	Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia. (17569567)	Harada N.... Nakagata N.	2007	IGF1
13	Vitamin D receptor gene polymorphisms are not associated with alopecia areata. (17822494)	Akar A.... Kurumlu Z.	2007	VDR
14	Loss-of-function mutations in the filaggrin gene and alopecia areata: strong risk factor for a severe course of disease in patients comorbid for atopic disease. (17581619)	Betz R.C.... Nothen M.M.	2007	FLG
15	Effect of 1 mg/day finasteride on concentrations of s erum prostate-specific antigen in men with androgenic alopecia: a randomised co ntrolled trial. (17196507)	D'Amico A.V.... Roehrborn C.G.	2007	KLK3
16	A unique insertion/duplication in the VDR gene that truncates the VDR causing hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia. (17078924)	Malloy P.J.... Feldman D.	2007	VDR
17	Failure of two TNF-alpha blockers to influence the co urse of alopecia areata. (16855408)	Abramovits W.... Losornio M.	2006	TNF
18	Investigation of the HLA-DRB1 locus in alopecia areata. (16935791)	Entz P.... Nothen M.M.	2006	HLA-DRB1
19	Premature androgenetic alopecia in adult male with nonclassic 21-OH deficiency. A novel nonsense CYP21A2 mutation (Y336X) in 2 affected siblings (17145028)	Bernal GonzA!lez C.... Ezquieta Zubicaray B.	2006	CYP21A2
20	The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata. (16829308)	Kemp E.H.... Tazi-Ahnini R.	2006	PTPN22
21	Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata. (17117947)	Schafer N.... Betz R.C.	2006	FCRL3
22	Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata. (15815686)	Shimizu T.... Shimizu H.	2005	MIF
23	The E211 G>A androgen receptor polymorphism is associated with a decreased risk of metastatic prostate cancer and androgenetic alopecia. (15824176)	Hayes V.M.... Giles G.G.	2005	AR
24	Interferon-gamma in alopecia areata. (14965793)	Arca E.... TaA9tan H.B.	2004	IL2, IFNG
25	Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study. (15149507)	Simonetti O.... Offidani A.	2004	CDKN2A, BIRC5, F8
26	Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population. (15180707)	Adriani M.... Pignata C.	2004	FOXN1
27	Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis. (15488702)	Midorikawa T.... Arase S.	2004	EFNA3
28	Finasteride in the treatment of alopecia. (15102575)	Libecco J.F.... Bergfeld W.F.	2004	SRD5A1
29	Coeliac disease and alopecia areata in childhood. (12603809)	Fessatou S.... Karpathios T.	2003	CD79A
30	Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. (12589427)	Tazi-Ahnini R.... McDonagh A.J.	2003	NOTCH4
31	Strong expression of CD40, CD54 and HLA-DR antigen and lack of evidence for direct cellular cytotoxicity are unique immunohistopathological features in alopecia areata. (12624779)	Sato-Kawamura M.... Tagami H.	2003	ICAM1, CD40
32	Androgens and alopecia. (12573818)	Kaufman K.D.	2002	SRD5A1
33	Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis. (12542742)	Tazi-Ahnini R.... Messenger A.G.	2002	AIRE
34	Atrichia with papular lesions resulting from compound heterozygous mutations in the hairless gene: A lesson for differential diagnosis of alopecia universalis. (12271294)	Henn W.... Christiano A.M.	2002	HR
35	Molecular mechanisms of androgenetic alopecia. (12213548)	TrA1eb R.M.	2002	AR
36	Androgenetic alopecia (12223962)	Jamin C.	2002	INS
37	Variant 1859G-->A (Arg620Gln) of the 'hairless' gene: absence of association with papular atrichia or androgenic alopecia. (11410842)	Hillmer A.M.... Cichon S.	2001	HR
38	Hormonal profile in men with premature androgenic alopecia (10953626)	StA!rka L.... PolA!cek V.	2000	SRD5A1, SHBG
39	Role of androgens in female-pattern androgenetic alopecia, either alone or associated with other symptoms of hyperandrogenism. (11214820)	Vexiau P.... Reygagne P.	2000	SHBG
40	Urinary steroids in women with androgenic alopecia. (10751586)	Juricskay S.... Telegdy E.	2000	SRD5A1
41	Successful treatment of alopecia areata-like hair loss with the contact sensitizer squaric acid dibutylester (SADBE) in C3H/HeJ mice. (10417620)	Freyschmidt-Paul P.... Hoffmann R.	1999	CIITA
42	Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice. (10674367)	Gilhar A.... Kalish R.S.	1999	ICAM1
43	Thymopentin in alopecia areata (9576023)	Gruber D.M.... Huber J.C.	1998	TMPO
44	Effects of interleukins, colony-stimulating factor and tumour necrosis factor on human hair follicle growth in vitro: a possible role for interleukin-1 and tumour necrosis factor-alpha in alopecia areata. (8977716)	Philpott M.P.... Kealey T.	1996	IL3, IL1A
45	Bone marrow-sparing and prevention of alopecia by AS101 in non-small-cell lung cancer patients treated with carboplatin and etoposide. (7666093)	Sredni B.... Kalechman Y.	1995	IL1A
46	A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia. (7923828)	O'Driscoll J.B.... Anderson D.C.	1994	PRL
47	HLA and ICAM-1 expression in alopecia areata in vivo and in vitro: the role of cytokines. (7506926)	McDonagh A.J.... Messenger A.G.	1993	ICAM1, IFNG
48	Simultaneous occurrence of SIADH, secondary hypogonadism and alopecia universalis in a woman with IDDM. (1666359)	Yasutomo Y.... Nagata N.	1991	INS
49	Aberrant intercellular adhesion molecule-1 (ICAM-1) expression by hair-follicle epithelial cells and endothelial leukocyte adhesion molecule-1 (ELAM-1) by vascular cells are important adhesion-molecule alterations in alopecia areata. (1708803)	Nickoloff B.J.... Griffiths C.E.	1991	ICAM1
50	Alopecia totalis: is treating nonresponder patients u seful? (2061445)	Tosti A.... Guerra L.	1991	TMPO

Genes related to alopecia according to GeneCards:

(show top 50)    (show all 179)

id	Symbol	Description	Score	GeneCards Section Context
1	HR	hairless homolog (mouse)	11.1	Summaries, Publications
2	FOXN1	forkhead box N1	11.1	Summaries, Publications
3	RBM28	RNA binding motif protein 28	11.1	Publications, Summaries
4	RIN2	Ras and Rab interactor 2	11.1	Summaries, Publications
5	AA1	Alopecia areata 1	11.0	Aliases & Descriptions
6	AA2	Alopecia areata 2	11.0	Aliases & Descriptions
7	AMRS	Alopecia-mental retardation syndrome	11.0	Aliases & Descriptions
8	APMR2	Alopecia with mental retardation syndrome 2	11.0	Aliases & Descriptions
9	AGA3	Alopecia, androgenetic, 3	11.0	Aliases & Descriptions
10	AGA2	Alopecia, androgenetic, 2	11.0	Aliases & Descriptions
11	AFA1	Alopecia, androgenetic	11.0	Aliases & Descriptions
12	APMR3	Alopecia-mental retardation syndrome 3	11.0	Aliases & Descriptions
13	ALX4	ALX homeobox 4	11.0	Summaries
14	AIRE	autoimmune regulator	11.0	Publications
15	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
16	INS	insulin	11.0	Publications
17	IFNG	interferon, gamma	11.0	Publications
18	CLDN1	claudin 1	11.0
19	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)	11.0	Publications
20	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0	Publications
21	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
22	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
23	AR	androgen receptor	11.0	Publications
24	IL1R1	interleukin 1 receptor, type I	11.0	Publications
25	SHBG	sex hormone-binding globulin	11.0	Publications
26	IL1A	interleukin 1, alpha	11.0	Publications
27	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
28	ICAM1	intercellular adhesion molecule 1	11.0	Publications
29	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
30	TGFB1	transforming growth factor, beta 1	11.0	Publications
31	TNF	tumor necrosis factor	11.0	Publications
32	ULBP3	UL16 binding protein 3	11.0	Publications
33	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	11.0	Publications
34	TCHH	trichohyalin	11.0	Publications
35	IKZF4	IKAROS family zinc finger 4 (Eos)	11.0	Publications
36	IGKC	immunoglobulin kappa constant	11.0	Publications
37	IL36RN	interleukin 36 receptor antagonist	11.0	Publications
38	CD200	CD200 molecule	11.0	Publications
39	EDA2R	ectodysplasin A2 receptor	11.0	Publications
40	DCAF17	DDB1 and CUL4 associated factor 17	11.0	Publications
41	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
42	KRT16	keratin 16	11.0	Publications
43	HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	11.0	Publications
44	STX17	syntaxin 17	11.0	Publications
45	T	T, brachyury homolog (mouse)	11.0	Publications
46	FCRL3	Fc receptor-like 3	11.0	Publications
47	HLA-DOA	major histocompatibility complex, class II, DO alpha	11.0
48	TNFSF13	tumor necrosis factor (ligand) superfamily, member 13	11.0	Publications
49	PART1	prostate androgen-regulated transcript 1 (non-protein coding)	11.0
50	ICOS	inducible T-cell co-stimulator	11.0	Publications

Pathways related to alopecia according to GeneDecks:

(show top 50)    (show all 142)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	11.3	IL1R1, FCGR1B, FCGR1A, CD40, CD200, CD34
2	Rheumatoid arthritis20	11.1	TGFB1, CTLA4, TNFSF13B, TNFSF13, TNF, HLA-DRB3
3	Leishmaniasis20	11.0	TGFB2, TGFB1, TNF, HLA-DRB3, HLA-DRB1, HLA-DQB1
4	Type I diabetes mellitus20	11.0	TNF, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
5	Influenza A20	10.9	CCL2, CIITA, HLA-DRB1, HLA-DQB1, CCL5, HLA-DOA
6	THC Differentiation Pathway36	10.9	IL4, IL2RA, IL2, IL10, TNFRSF1A, TNF
7	Graft-versus-host disease20	10.9	HLA-DRB3, HLA-DQA2, HLA-DQA1, HLA-DOA, HLA-C, HLA-B
8	Allograft rejection20	10.9	TNF, FASLG, IL4, IL2, IL10, GZMB
9	Asthma20	10.9	IL4, IL3, IL10, CD40, CCL11, HLA-DOA
10	Intestinal immune network for IgA production20	10.9	TGFB1, TNFSF13B, TNFSF13, HLA-DRB3, HLA-DRB1, HLA-DQB1
11	Tuberculosis20	10.8	HLA-DOA, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, CYP27B1
12	Autoimmune thyroid disease20	10.8	CTLA4, TPO, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
13	Toxoplasmosis20	10.7	HLA-DOA, HLA-DRB3, HLA-DRB1, TGFB2, IKBKG, HLA-DQB1
14	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.6	TGFB2, TNFRSF1A, TNF, FAS, TGFB1, FASLG
15	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.6	CCL4, GZMB, IL2, IL2RA, FASLG, TNFRSF1A
16	CTL Mediated Apoptosis36	10.5	HLA-C, HLA-DQA2, GZMB, HLA-A, HLA-DQA1, HLA-B
17	Cell adhesion molecules (CAMs)20	10.5	ICOS, CTLA4, CD4, HLA-DQA2, HLA-DOA, CD40
18	Chagas disease (American trypanosomiasis)20	10.5	IL1B, IL10, TNFRSF1A, TGFB2, TGFB1, TNF
19	PGC1Alpha Pathway36	10.5	CCL4, IL8, IL4, IL3, IL2, IL1R1
20	Cytokine Network36	10.5	IL1B, IFNG, IL8, IL4, IL3, IL2
21	NFAT Signaling and Lymphocyte Interactions36	10.4	TNFSF13B, CCL2, CCL27, CCL11, CD4, IL2
22	Antigen processing and presentation20	10.4	HLA-DRB3, HLA-DRB1, CD4, HLA-C, HLA-DOA, CIITA
23	Glucocorticoid Receptor Signaling36	10.2	CCL4, NCOA1, CD4, IL10, IL8, IL4
24	Staphylococcus aureus infection20	10.2	FCGR1A, IL10, ICAM1, HLA-DOA, HLA-DQA1, HLA-DQA2
25	SOCS Pathway36	10.2	IL3, IL2, CD4, INS, IL10, IL8
26	Regulation of eIF4 and p70S6K36	10.1	IL3, CD4, IL16, IL1A, IL2, IL4
27	RAR-Gamma-RXR-Alpha Degradation36	10.0	CCL11, CCL5, TNFSF13, TNFSF13B, CXCL9, CSF3
28	Akt Signaling36	10.0	PSIP1, TGFB2, TNFSF13B, TNFRSF1A, TNF, IKBKG
29	all-trans-Retinoic Acid Signaling in Brain36	10.0	CXCL9, IL10, TNFSF13B, TNFSF13, TNF, CCL5
30	MIF Regulation of Innate Immune Cells36	10.0	CCL4, CCL27, CCL2, CCL11, CCL5, TNF
31	MIF Mediated Glucocorticoid Regulation36	10.0	CCL2, CCL11, CCL5, TNF, TNFSF13, TNFSF13B
32	IL-6 Pathway36	9.9	CCL11, CCL5, TNFSF13, TNFSF13B, CXCL9, CSF3
33	Malaria20	9.9	TGFB2, CSF3, TGFB1, ICAM1, CD40, IL8
34	Pathways in cancer20	9.9	IKBKG, CDK2, TGFB1, EGFR, CTNNB1, PTCH2
35	TGF-Beta Pathway36	9.8	PSIP1, IL8, IL4, IL3, IL2RA, IL2
36	PEDF Induced Signaling36	9.8	CFLAR, IL10, IL16, IL1A, IL1B, IL2
37	Tec Kinases Signaling36	9.7	IL8, IL4, IL3, IL2RA, IL2, IL16
38	Endothelin-1 Signaling Pathway36	9.7	IL16, IL1A, IL1B, IL2, IL21, IL3
39	STAT3 Pathway36	9.7	TNF, CCL5, CCL11, CCL2, CCL27, CCL4
40	MAPK Family Pathway36	9.6	PSIP1, TGFB2, TGFB1, IL8, IL4, IL3
41	ERK Signaling36	9.3	KIT, TNFSF13, TNFSF13B, COL17A1, EGFR, TGFB1
42	Cytokine-cytokine receptor interaction20	9.1	TNFSF13B, TNFSF13, TNFRSF1A, TNF, TPO, IFNG
43	JAK-STAT Pathway36	9.1	IL1B, IL1A, IL16, IL10, CD4, KITLG
44	PAK Pathway36	9.0	CCL11, IGF1, TNF, TNFSF13, TNFSF13B, EGFR
45	NFAT in Immune Response36	8.9	CD4, IGF1, IKBKG, HLA-DRB3, IL2, FCGR1A
46	Hematopoietic cell lineage20	8.8	CD34, CD4, KITLG, KIT, TPO, HLA-DRB3
47	Rho Family GTPases36	8.7	ELN, COL17A1, TNFSF13B, TNFSF13, IGF1, CCL5
48	p38 Signaling36	8.7	TGFB2, PSIP1, CXCL9, CSF3, TGFB1, CD4
49	Antioxidant Action of Vitamin-C36	8.4	IL16, CCL27, CCL4, IL8, CCL2, CCL11
50	Molecular Mechanisms of Cancer36	INF	KITLG, CFLAR, , CDK2, CDKN2A, CD4

Compounds related to alopecia according to GeneDecks:

(show top 50)    (show all 432)

id	Compound	Score	Top Affiliating Genes
1	ly29400232	10.9	CFLAR, GZMB, IL10, IL1B, IL4, IL8
2	ascorbic acid32 18	11.3	VDR, FLG, AR, IL1A, IL1R1, IL2RA
3	pdtc32	10.3	BIRC5, XIAP, XDH, CFLAR, CD40, IL1A
4	dhea32	10.3	AR, INS, MC2R, FASLG, IGF1, HLA-B
5	tacrolimus32 34 9 9	13.2	VDR, CD79A, CD40, GZMB, INS, IL10
6	oxygen32 18	11.2	KITLG, BIRC5, CIITA, XIAP, CFLAR, CDK2
7	glucose32	10.1	KIT, BTD, XIAP, CFLAR, GZMB, MIF
8	estradiol32 9 18 9	13.1	NCOA1, KITLG, BIRC5, MUC1, XIAP, CFLAR
9	calcipotriol32 42 9 9	13.1	VDR, FLG, IL1A, IL8, ICAM1, CYP27B1
10	histamine32 18	11.1	KIT, KITLG, CD79A, CD40, IL16, IL1RN
11	neopterin32	10.0	MX1, CD79A, CD4, CD40, GZMB, IL10
12	rapamycin32 42	11.0	KIT, KITLG, CFLAR, CDK2, GZMB, AR
13	sb 20358032 42	11.0	VDR, BIRC5, IL1R1, CCL4, CCL11, CCL5
14	pge232	9.9	CIITA, CD4, AR, FCGR1A, IL1A, IL1R1
15	glutamate32	9.9	NCOA1, VDR, XIAP, CD79A, CDK2, CD4
16	tarc32	9.9	CD4, IL10, IL1A, IL4, IL8, CCL4
17	endotoxin32	9.9	CIITA, CD40, MIF, IL1R1, FASLG, CCL4
18	aspartate32	9.8	VDR, CDKN2A, GZMB, APOA1, FASLG, CCL27
19	prednisolone32 9 9	11.8	KITLG, CD79A, CD40, GZMB, FCGR1A, IL10
20	mifepristone32 42 9 9	12.8	NCOA1, BIRC5, MUC1, CDK2, AR, IL1B
21	ccl332	9.7	IL10, IL1A, IL1B, IL1R1, IL8, CCL4
22	herbimycin a32 42	10.7	KITLG, CDK2, CD4, CD40, MIF, FCGR1A
23	dihydrotestosterone32 9 18 9	12.7	NCOA1, VDR, MUC1, CD79A, CDK2, CD40
24	cysteine32	9.7	BTD, VDR, MUC1, XIAP, XDH, CFLAR
25	nitric oxide32 9 18 9	12.6	KIT, KITLG, BIRC5, CIITA, MUC1, XDH
26	calcitriol32 42 9 18 9	13.4	NCOA1, KITLG, VDR, XIAP, CDK2, FLG
27	indomethacin32 9 9	11.3	NCOA1, BIRC5, CD79A, CDK2, CD40, IL1A
28	doxorubicin32 34 9 9	12.3	KIT, KITLG, XIAP, CFLAR, CDK2, CD40
29	progesterone32 42 9 18 9	13.3	NCOA1, KIT, BIRC5, CDK2, CDKN2A, CD34
30	lactate32	9.2	KIT, KITLG, BTD, BIRC5, XDH, CD79A
31	tamoxifen32 34 9 9	12.2	NCOA1, VDR, BIRC5, MUC1, CDK2, AR
32	estrogen32	9.0	NCOA1, VDR, CD34, GZMB, MIF, AR
33	hydrocortisone32 9 9	10.9	KITLG, MUC1, CD40, MIF, INS, IL10
34	steroid32	8.8	NCOA1, KIT, KITLG, VDR, BIRC5, CIITA
35	paraffin32	8.7	KIT, KITLG, BIRC5, MUC1, XIAP, CD79A
36	actinomycin d32	8.5	KIT, KITLG, VDR, BIRC5, CIITA, MUC1
37	testosterone32 9 18 9	11.4	NCOA1, KIT, KITLG, VDR, BIRC5, MUC1
38	paclitaxel32 34 9 9	11.4	KIT, KITLG, BIRC5, XIAP, CFLAR, CDK2
39	glutamine32	8.2	NCOA1, KIT, VDR, CDK2, AR, FCGR1A
40	5fluorouracil32	8.1	KIT, KITLG, VDR, BIRC5, MUC1, XIAP
41	dexamethasone32 42 34 9 9	11.8	KITLG, VDR, BIRC5, CIITA, MUC1, XIAP
42	thymidine32 18	8.8	KIT, KITLG, VDR, BIRC5, CIITA, MUC1
43	cisplatin32 34 9 9	10.8	KITLG, BIRC5, MUC1, XIAP, XDH, CFLAR
44	vegf32	7.0	KIT, KITLG, MUC1, XIAP, CFLAR, CDK2
45	cycloheximide32	6.9	KIT, KITLG, VDR, BIRC5, CIITA, MX1
46	tyrosine32	INF	NCOA1, KIT, KITLG, BTD, BIRC5, CIITA
47	calcium32 9 18 9	INF	KIT, KITLG, LMNA, BIRC5, ULBP3, CIITA
48	serine32	INF	NCOA1, KIT, KITLG, BTD, VDR, LMNA
49	genistein32 9 18 9	INF	NCOA1, KITLG, VDR, BIRC5, , CDK2
50	phosphatidylinositol32	INF	KIT, KITLG, BIRC5, CIITA, XIAP, CFLAR

Cellular components related to alopecia according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	clathrin-coated endocytic vesicle membrane	GO:030669	10.8	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, APOB
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.7	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-C
3	ER to Golgi transport vesicle membrane	GO:012507	10.7	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-C
4	MHC class II protein complex	GO:042613	10.6	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-DOA
5	transport vesicle membrane	GO:030658	10.5	HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, HLA-DRB3
6	MHC class I protein complex	GO:042612	10.5	HLA-C, HLA-B, HLA-A, MICA, ULBP3
7	endocytic vesicle membrane	GO:030666	10.4	NOS3, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
8	external side of plasma membrane	GO:009897	10.2	ICAM1, ICOS, HLA-DRB1, HLA-DRB3, TNF, CTLA4
9	trans-Golgi network membrane	GO:032588	10.2	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
10	integral to plasma membrane	GO:005887	10.1	TNFRSF1A, TNF, TPO, HLA-DRB3, HLA-DRB1, CTLA4
11	keratin filament	GO:045095	9.8	KRT14, KRT85, KRT10, KRT75, KRT81, KRT86
12	intermediate filament	GO:005882	9.7	NES, DSP, KRT14, KRT15, KRT10, KRT86
13	extracellular region	GO:005576	9.1	NOTCH3, TNFRSF1A, HLA-C, ICOS, F8, IFNG
14	plasma membrane	GO:005886	8.9	HLA-DRB3, TPO, TNF, TNFRSF1A, TNFSF13B, HLA-DRB1
15	extracellular space	GO:005615	8.1	EPO, TNF, HTRA1, ICAM1, F8, IFNG

Biological processes related to alopecia according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	interferon-gamma-mediated signaling pathway	GO:060333	11.1	HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-C
2	regulation of immune response	GO:050776	11.0	HLA-C, HLA-B, HLA-A, ICAM1, IGKC, IL4
3	positive regulation of nitric oxide biosynthetic process	GO:045429	10.9	EGFR, TNF, ICAM1, IFNG, IL1B, INS
4	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.9	TGFB1, EDA2R, TNF, TRAF1, ICAM1, IKBKG
5	lipopolysaccharide-mediated signaling pathway	GO:031663	10.9	TGFB1, NOS3, TNF, CCL5, CCL2, IL1B
6	positive regulation of angiogenesis	GO:045766	10.9	C5, NOS3, TNFRSF1A, CCL5, CCL11, IL1B
7	positive regulation of isotype switching to IgG isotypes	GO:048304	10.8	IFNG, IL4, IL2, CD40
8	positive regulation of cytokine secretion	GO:050715	10.8	TNF, IL1A, IL10, INS, MIF
9	positive regulation of MHC class II biosynthetic process	GO:045348	10.8	IFNG, IL4, IL10, CIITA
10	cellular calcium ion homeostasis	GO:006874	10.8	C5, TGFB1, CCL5, CCL11, CCL2, CD40
11	cell-cell signaling	GO:007267	10.8	CCL5, SRD5A2, TGFB2, CXCL9, POMC, EFNA3
12	MAPK cascade	GO:000165	10.8	TGFB1, EGFR, TNF, CCL5, CCL2, IL1B
13	positive regulation of chemokine biosynthetic process	GO:045080	10.8	TNF, IFNG, IL4, IL1B
14	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	10.7	TNF, IFNG, IL1B
15	protein kinase B signaling cascade	GO:043491	10.7	TGFB1, TNF, CCL5, CCL2, IL1B
16	response to heat	GO:009408	10.6	SOD1, PSIP1, NOS3, CCL2, IL1B, MICA
17	chronic inflammatory response to antigenic stimulus	GO:002439	10.6	IL1RN, IL1B
18	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.6	TNFRSF1A, TNF, TRAF1, IKBKG, FASLG, IL1B
19	response to estradiol stimulus	GO:032355	10.6	NCOA1, VDR, IL1B, CYP19A1, CTNNB1, NOS3
20	T cell costimulation	GO:031295	10.6	CTLA4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
21	chemotaxis	GO:006935	10.6	C5, CXCL9, CCL5, CCL11, CCL2, CCL27
22	positive regulation of tyrosine phosphorylation of Stat1 protein	GO:042511	10.6	TNFRSF1A, IFNG, CD40, KIT
23	response to glucocorticoid stimulus	GO:051384	10.4	CCL5, CCL2, FAS, IL1RN, IL1B, IL10
24	cellular response to organic cyclic compound	GO:071407	10.4	TGFB1, PPARG, CTNNB1, SRD5A1, TNF, CCL5
25	positive regulation of apoptotic process	GO:043065	10.4	SOD1, TGFB2, NOS3, CTNNB1, CTLA4, TNF
26	negative regulation of apoptotic process	GO:043066	10.4	EGFR, TGFB2, PRDX5, NES, EPO, TNF
27	aging	GO:007568	10.4	EPO, TGFB2, TGFB1, NOS3, CCL5, CCL2
28	inflammatory response	GO:006954	10.3	C5, CCL4, IL8, IL1B, IL1A, IL10
29	T cell receptor signaling pathway	GO:050852	10.3	PTPN22, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
30	induction of apoptosis	GO:006917	10.2	C5, TGFB2, TGFB1, PPARG, TNF, TP63
31	hemopoiesis	GO:030097	10.2	EBP, TGFB2, NOTCH4, TXNRD2, IL10, CD34
32	positive regulation of gene expression	GO:010628	10.2	NKX2-1, TGFB2, TGFB1, CCL5, MED1, CD34
33	epidermis development	GO:008544	10.1	KRT85, KRT14, EDA2R, DSP, STS, KRT15
34	embryonic hemopoiesis	GO:035162	10.1	TPO, IL3, MED1, KITLG, KIT
35	cytokine-mediated signaling pathway	GO:019221	10.0	HLA-B, HLA-C, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
36	cell proliferation	GO:008283	10.0	PRL, HLCS, TGFB2, ELN, KITLG, CD34
37	cell surface receptor signaling pathway	GO:007166	10.0	C5, PRL, EGFR, IFNG, CCL2, IL2RA
38	virus-host interaction	GO:019048	10.0	HLA-C, TNFRSF1A, KRT7, TOP1, TGFB1, PSIP1
39	immune response	GO:006955	9.9	CSF3, IGKC, ICOS, AIRE, HLA-A, HLA-B
40	response to drug	GO:042493	9.9	TNF, ICAM1, IFNG, CCL5, CCL2, FAS
41	response to lipopolysaccharide	GO:032496	9.7	EPO, NKX2-1, CYP27B1, TNFRSF1A, FAS, FASLG
42	apoptotic process	GO:006915	9.7	IFNG, TRAF1, TP63, TNF, TNFRSF1A, CTNNB1
43	positive regulation of DNA replication	GO:045740	9.7	EPO, EGFR, IGF1, IL3, INS, KITLG
44	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.7	EPO, IGF1, IL4, IL3, IL2, KIT
45	keratinocyte differentiation	GO:030216	9.6	TGM1, DSP, KRT10, TP63, MED1, FLG
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.6	ALX4, AIRE, TP63, TNF, TNFRSF1A, CTNNB1
47	anti-apoptosis	GO:006916	9.5	FAS, CCL2, IGF1, TNF, NOS3, SOD1
48	positive regulation of cell proliferation	GO:008284	8.7	TNFSF13, TNFSF13B, EGFR, TGFB1, TGFB2, STS
49	positive regulation of transcription, DNA-dependent	GO:045893	8.5	AIRE, TP63, TNF, CTNNB1, PPARG, NOTCH4
50	signal transduction	GO:007165	8.5	TNFSF13, TRAF1, HLA-DRB3, IGF1, CCL11, CCL2

Molecular functions related to alopecia according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	10.7	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-DOA
2	chemokine activity	GO:008009	10.6	C5, CXCL9, CCL5, CCL11, CCL2, CCL27
3	CCR5 chemokine receptor binding	GO:031730	10.5	CCL4, CCL5, NES
4	receptor binding	GO:005102	10.4	TNFSF13B, TGFB2, PRDX5, POMC, C5, TNFSF13
5	MHC class I receptor activity	GO:032393	10.2	HLA-C, HLA-B, HLA-A, ULBP3
6	cytokine activity	GO:005125	9.7	KITLG, CCL4, IFNG, TNF, TNFSF13, TNFSF13B
7	structural molecule activity	GO:005198	9.5	KRT75, KRT10, KRT85, DSP, NES, KRT81
8	growth factor activity	GO:008083	8.9	CSF3, TGFB2, TGFB1, IGF1, IL4, IL3
9	enzyme binding	GO:019899	8.1	PPARG, NOTCH3, EGFR, TGFB1, CSF3, HLCS
10	protein binding	GO:005515	INF	TMPO, PTCH1, PTPN22, CTLA4, CTNNB1, PPARG