MCID: ALP008
MIFTS: 60

Alopecia malady

Summaries for Alopecia

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Hair loss or baldness (technically known as alopecia) is a loss of hair from the head or body. Baldness... more...

MalaCards: Alopecia is related to alopecia areata and alopecia universalis. An important gene associated with Alopecia is HR (hair growth associated), and among its related pathways are Metabolism of steroid hormones and vitamin D and Androgen biosynthesis. The compounds androstenedione and dehydroepiandrosterone sulfate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Disease Ontology:8 A hypotrichosis that is characterized by a loss of hair from the head or body.

Description from OMIM:46 109200,300042

Aliases & Classifications for Alopecia

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8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 46OMIM, 27ICD9CM, 56SNOMED-CT, 60UMLS, 34MeSH, 39NCIt
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Aliases & Descriptions:

alopecia 8 20 22 10


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Disease Ontology8 DOID:987
ICD9CM27 704.0, 704.00
MeSH34 D000505
NCIt39 C50575

Related Diseases for Alopecia

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17GeneCards, 18GeneDecks
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Diseases related to Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 436)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia areata31.7IFNG, AIRE
2alopecia universalis31.2HR
3androgenic alopecia31.0SHBG, CYP21A2, SRD5A2, SRD5A1
4acne30.3SHBG
5hypothyroidism30.1INS, AIRE, SHBG
6hypogonadism30.1INS, SHBG
7diabetes mellitus30.1AIRE, SHBG, INS
8hyperandrogenism30.1CYP21A2, SHBG, INS, SRD5A1
9autoimmune thyroiditis30.1IFNG, AIRE, CYP21A2
10candidiasis30.1IFNG, AIRE
11graves' disease29.8AIRE, SHBG, IFNG, CYP21A2
12polycystic ovary syndrome29.6CYP21A2, SHBG, SRD5A1, INS
13hyperprolactinemia29.6SRD5A1, SHBG
14infertility29.6INS, CYP21A2, SHBG
15cryptorchidism29.6SHBG, SRD5A1
16adrenoleukodystrophy29.6CYP21A2
17impotence29.6SRD5A1, SHBG
18diffuse alopecia areata10.4
19vitiligo10.4
20lupus erythematosus10.4
21psoriasis10.4
22telogen effluvium10.4
23follicular mucinosis10.4
24alopecia totalis10.3
25trichotillomania10.3
26dermatitis10.3
27lichen planus10.3
28thyroiditis10.3
29rickets10.3
30hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
31folliculitis10.2
32prostatitis10.2
33t-cell immunodeficiency, congenital alopecia and nail dystrophy10.2
34ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.2
35frontal fibrosing alopecia10.2
36hepatitis10.2
37congenital alopecia x-linked10.2
38thumb deformity, alopecia, pigmentation anomaly10.2
39alopecia-intellectual deficit syndrome10.2
40cronkhite-canada syndrome10.2
41syphilis10.2
42central centrifugal cicatricial alopecia10.2
43autosomal recessive palmoplantar keratoderma and congenital alopecia10.2
44crohn's disease10.1
45hepatitis c10.1
46secondary syphilis10.1
47prostate cancer10.1
48tinea capitis10.1
49alopecia mental retardation syndrome 210.1
50cataract, alopecia, sclerodactyly10.1

Graphical network of the top 20 diseases related to Alopecia:



Diseases related to alopecia

Clinical Features for Alopecia

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46OMIM
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Clinical features from OMIM:

109200,300042

Drugs & Therapeutics for Alopecia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Alopecia

Drug clinical trials:

Search ClinicalTrials for Alopecia

Search NIH Clinical Center for Alopecia

Search CenterWatch for Alopecia

Genetic Tests for Alopecia

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20GeneTests, 22GTR
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Genetic tests related to Alopecia:

id Genetic test Affiliating Genes
1 Alopecia20 22

Anatomical Context for Alopecia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Alopecia:

32
Skin, T cells, Thyroid, Prostate, Breast, Testes, Bone, Pituitary, Endothelial, Heart, Bone marrow, Tongue, Lung, Monocytes, Ovary, Liver, Colon, Thymus, Eye, Nk cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alopecia:
id TissueAnatomical CompartmentCell Relevance
1 HairHair FollicleFetal Hair Placode Cells Affected by disease
2 HairHair FollicleFetal Matrix Cells Affected by disease
3 DermisDermal PapillaGuard Dermal Papilla Cells Affected by disease
4 HairHair FolliclePrimary Hair Placode Cells Affected by disease

Animal Models for Alopecia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alopecia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.9FOXN1, AIRE, INS, HR, SRD5A1, SRD5A2
2MP:000537910.6SRD5A2, IFNG, FOXN1, AIRE, INS, HR

Publications for Alopecia

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50PubMed
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Articles related to Alopecia:

(show top 50)    (show all 1592)
idTitleAuthorsYear
1
Congenital triangular alopecia. (24403390)
2014
2
Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children: A Randomized Clinical Trial. (24226568)
2014
3
PTPN22 profile indicates a novel risk group in Alopecia areata. (24055692)
2014
4
Increased androgen receptor messenger RNA in frontal-parietal hair follicles of women with androgenetic alopecia. (23479164)
2013
5
Alopecia areata developing during ustekinumab therapy: report of two cases. (24334218)
2013
6
CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase. (23312578)
2013
7
Association of early-onset androgenetic alopecia and metabolic syndrome in Thai men: a case-control study. (23991602)
2013
8
Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University. (23375454)
2013
9
Serum thymus and activation-regulated chemokine as disease activity and response biomarker in alopecia areata. (24102731)
2013
10
Erratum to: Clinical Efficacy of a Cosmetic Treatment by Crescina(Ar) Human Follicle Stem Cell on Healthy Males with Androgenetic Alopecia. (24318483)
2013
11
Paradise nut paradox: alopecia due to selenosis from a nutritional therapy. (23766617)
2012
12
Reducing chemotherapy-induced alopecia with scalp cooling. (23187775)
2012
13
Alopecia areata. (22512484)
2012
14
Topical and intralesional therapies for alopecia areata. (21689245)
2011
15
Camouflage technique for alopecia areata: What is a patient to do? (21689239)
2011
16
Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with androgenetic alopecia mediated by epigenetics. (21410621)
2011
17
The coudability sign of alopecia areata: the real story. (21392077)
2011
18
Genetic association of HLA-DQB1 and HLA-DRB1 polymorphisms with alopecia areata in the Italian population. (21692766)
2011
19
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (20596022)
2010
20
Renbok phenomenon and contact sensitization in a patient with alopecia universalis. (20404233)
2010
21
Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata. (19301021)
2009
22
Alopecia areata universalis after phenobarbital-induced anti-convulsant hypersensitivity syndrome. (19811415)
2009
23
Bald is beautiful?: the psychosocial impact of alopecia areata. (19129346)
2009
24
Trichomegaly in a 3-year-old girl with alopecia areata. (19419469)
2009
25
Serum selenium level in Iranian patients with alopecia areata. (18452532)
2008
26
Comparison of the efficacy and safety of topical minoxidil and topical alfatradiol in the treatment of androgenetic alopecia in women. (17451383)
2007
27
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness. (18032861)
2007
28
Localized sclerosis of the scalp (alopecia porphyrinica) as predominant presentation of porphyria cutanea tarda. (17714148)
2007
29
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. (16914743)
2006
30
Acute alopecia totalis. (16850096)
2006
31
Alopecia universalis in Down syndrome: response to therapy. (17179625)
2006
32
Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study. (15149507)
2004
33
Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population. (15180707)
2004
34
Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis. (12833016)
2003
35
Targeted expression of human vitamin d receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice. (11918709)
2002
36
Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction. (11841485)
2002
37
Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia. (11050579)
2000
38
Serum androgens and genetic linkage analysis in early onset androgenetic alopecia. (10469317)
1999
39
Alopecia universalis associated with a mutation in the human hairless gene. (9445480)
1998
40
Angiogenic activity is defective in monocytes from patients with alopecia universalis. (1696299)
1990
41
Treatment of female androgenetic alopecia with cimetidine. (3570585)
1987
42
Vitamin D-dependent rickets type II: extreme end organ resistance to 1,25-dihydroxy vitamin D3 in a patient without alopecia. (3024987)
1986
43
Spontaneous cell-mediated cytotoxicity (SCMC) in patients with alopecia universalis. (6172934)
1981
44
Fatty-acid-responsive alopecia in multiple carboxylase deficiency. (6103410)
1980
45
Coincidence of vitiligo, alopecia areata, onychodystrophy, localized scleroderma and lichen planus. (478074)
1979
46
Corticosteroids in the treatment of alopecia totalis. Systemic effects. (718184)
1978
47
Traumatic alopecia in trichotillomania: a pathogenic interpretation of histologic lesions in the pilosebaceous unit. (915050)
1977
48
Alopecia totalis after desacetylmethylcolchicine therapy of acute gout; report of a case. (13369711)
1956
49
Alopecia areata associated with neurodermatitis; report of two cases with a discussion of the relationship of alopecia areata to nervous system dysfunction. (18878574)
1948
50
Alopecia Totalis after Slight Nervous Shock. (19987431)
1930

Genetic Variations for Alopecia

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Expression for genes affiliated with Alopecia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alopecia

Search GEO for disease gene expression data for Alopecia.

Pathways for genes affiliated with Alopecia

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7SRD5A2, SRD5A1, CYP21A2
2
Hide members
10.6SRD5A2, SRD5A1

Compounds for genes affiliated with Alopecia

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44Novoseek, 24HMDB, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Alopecia according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1androstenedione44 2412.2SRD5A2, SRD5A1, INS, CYP21A2, SHBG
2dehydroepiandrosterone sulfate4411.2INS, CYP21A2, SRD5A1, SHBG
3dhea4411.1SRD5A1, INS, CYP21A2, SHBG
4hydrocortisone44 2 59 1114.1SHBG, INS, CYP21A2, IFNG
5dihydrotestosterone44 28 11 2414.1CYP21A2, SRD5A2, SHBG, SRD5A1
6desogestrel44 1112.1SRD5A1, INS, SHBG
7auranofin44 59 28 1114.1SRD5A2, IFNG, SRD5A1
8clomiphene citrate4411.1INS, CYP21A2, SHBG
9finasteride44 59 11 2414.1SHBG, SRD5A1, SRD5A2
103-alpha-androstanediol glucuronide44 2412.1SRD5A1, CYP21A2, SHBG
11cortisone44 2412.1CYP21A2, INS, SRD5A1
12cyproteroneacetate4411.1SHBG, INS, SRD5A1
13gnrh4411.1INS, SRD5A1, SHBG, CYP21A2
1417-hydroxyprogesterone44 2412.1SHBG, SRD5A1, CYP21A2
15spironolactone49 44 59 28 1115.1SHBG, SRD5A1, CYP21A2
163beta-hydroxysteroid4411.0CYP21A2, SRD5A1, SRD5A2
1717beta-hydroxysteroid4411.0SRD5A2, CYP21A2, SRD5A1
18ketoconazole44 28 11 2414.0SRD5A1, CYP21A2, SHBG
19phenytoin44 49 28 1114.0CYP21A2, SHBG, SRD5A1
20es 9365911.0SRD5A2, SRD5A1
21testosterone44 59 11 2414.0SHBG, CYP21A2, INS, SRD5A1, SRD5A2
22c-peptide4411.0INS, SHBG, CYP21A2
23epitestosterone4411.0SRD5A1, SHBG
24enterolactone4411.0SHBG, SRD5A1
25formestane4411.0SHBG, SRD5A1
26ment4411.0SRD5A1, SHBG
27norgestimate44 1111.9SHBG, SRD5A1
28dutasteride44 1111.9SRD5A1, SRD5A2
29androstenediol4410.9SRD5A1, SHBG
30oxandrolone44 1111.9SHBG, INS
315alpha-dihydroprogesterone4410.9SRD5A2, SRD5A1
32androstanedione44 11 2412.9SRD5A1, SRD5A2
3317-hydroxypregnenolone4410.9SHBG, CYP21A2
34acarbose44 1111.9SHBG, INS
35goserelin44 28 1112.9SRD5A1, SHBG
3611 deoxycortisol4410.9SHBG, CYP21A2
37doca4410.8SRD5A1, CYP21A2
38allopregnanolone4410.8SHBG, SRD5A1
39dexamethasone44 49 28 1113.8CYP21A2, INS, SRD5A1, SHBG, IFNG
405alpha-androstane-3alpha,17beta-diol4410.8SRD5A1, SHBG
41hydroxyflutamide44 2811.7SHBG, SRD5A1
42prednisolone44 28 1112.7IFNG, SHBG, CYP21A2
43leuprolide acetate4410.7SHBG, CYP21A2
44androsterone glucuronide44 2411.6SHBG, SRD5A1
45exemestane49 44 59 1113.5SRD5A1, SHBG
46estradiol44 11 2412.4SRD5A1, SHBG, SRD5A2, CYP21A2

GO Terms for genes affiliated with Alopecia

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16Gene Ontology
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Biological processes related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen biosynthetic processGO:00670210.6SRD5A2, SRD5A1
2steroid metabolic processGO:00820210.4SRD5A2, SRD5A1, CYP21A2

Molecular functions related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholestenone 5-alpha-reductase activityGO:04775110.6SRD5A2, SRD5A1
23-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2, SRD5A1

Products for genes affiliated with Alopecia

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Sources for Alopecia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet