MCID: ALP008
MIFTS: 56

Alopecia malady

Genetic diseases (common) category

Summaries for Alopecia

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9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Hair loss or baldness (technically known as alopecia) is a loss of hair from the head or body. Baldness... more...

MalaCards: Alopecia is related to alopecia areata and alopecia universalis. An important gene associated with Alopecia is HR (hair growth associated), and among its related pathways are Th17 Differentiation and Downstream signaling in naive CD8+ T cells. The compounds alpha-galactosylceramide and 17-hydroxypregnenolone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are integument and tumorigenesis.

Disease Ontology:9 A hypotrichosis that is characterized by a loss of hair from the head or body.

Description from OMIM:48 300042,109200

Aliases & Classifications for Alopecia

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9Disease Ontology, 21GeneTests, 23GTR, 11DISEASES, 28ICD9CM, 48OMIM, 59SNOMED-CT, 36MeSH, 41NCIt, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

alopecia 9 21 23 11


External Ids:

Disease Ontology9 DOID:987
ICD9CM28 704.0, 704.00
MeSH36 D000505
NCIt41 C50575

Related Diseases for Alopecia

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18GeneCards, 19GeneDecks
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Diseases related to Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 483)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia areata31.7AIRE, IFNG, GZMB
2alopecia universalis31.5HR
3androgenic alopecia30.9SHBG, CYP21A2
4acne30.5SHBG
5hypothyroidism30.3SHBG, AIRE
6candidiasis30.2IFNG, AIRE
7hypogonadism30.2SHBG
8myasthenia gravis30.2IFNG, AIRE
9hyperandrogenism30.2CYP21A2, SHBG
10autoimmune thyroiditis29.9AIRE, CYP21A2, IFNG
11graves' disease29.8AIRE, CYP21A2, SHBG, IFNG
12turner syndrome29.7SHBG, CYP21A2
13polycystic ovary syndrome29.7SHBG, CYP21A2
14male infertility29.7SHBG, CYP21A2
15aplastic anemia29.6IFNG, GZMB
16graft versus host disease29.6GZMB, IFNG
17celiac disease29.6CYP21A2, GZMB
18alopecia totalis10.7
19frontal fibrosing alopecia10.7
20central centrifugal cicatricial alopecia10.5
21vitiligo10.5
22lupus erythematosus10.4
23psoriasis10.4
24telogen effluvium10.4
25follicular mucinosis10.4
26trichotillomania10.4
27dermatitis10.4
28lichen planus10.3
29thyroiditis10.3
30hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
31discoid lupus erythematosus10.3
32diffuse alopecia areata10.3
33rickets10.3
34blindness10.3
35folliculitis10.3
36prostatitis10.3
37ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.3
38t-cell immunodeficiency, congenital alopecia and nail dystrophy10.3
39alopecia-intellectual disability syndrome10.3
40hepatitis10.2
41congenital alopecia x-linked10.2
42thumb deformity, alopecia, pigmentation anomaly10.2
43syphilis10.2
44insulin resistance10.2
45autosomal recessive palmoplantar keratoderma and congenital alopecia10.2
46crohn's disease10.2
47hepatitis c10.2
48cronkhite-canada syndrome10.2
49secondary syphilis10.2
50prostate cancer10.2

Graphical network of the top 20 diseases related to Alopecia:



Diseases related to alopecia

Symptoms for Alopecia

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48OMIM
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Clinical features from OMIM:

300042,109200

Drugs & Therapeutics for Alopecia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Alopecia

Drug clinical trials:

Search ClinicalTrials for Alopecia

Search NIH Clinical Center for Alopecia

Search CenterWatch for Alopecia

Genetic Tests for Alopecia

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21GeneTests, 23GTR
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Genetic tests related to Alopecia:

id Genetic test Affiliating Genes
1 Alopecia21 23

Anatomical Context for Alopecia

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32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Alopecia:

34
Skin, T cells, Thyroid, Prostate, Breast, Bone, Testes, Pituitary, Endothelial, Heart, Bone marrow, Tongue, Monocytes, Ovary, Liver, Lung, Thymus, Nk cells, Eye, Colon

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alopecia:
id TissueAnatomical CompartmentCell Relevance
1 HairHair FollicleFetal Hair Placode Cells Affected by disease
2 HairHair FollicleFetal Matrix Cells Affected by disease
3 DermisDermal PapillaGuard Dermal Papilla Cells Affected by disease
4 HairHair FolliclePrimary Hair Placode Cells Affected by disease

Animal Models for Alopecia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Alopecia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.1HR, ALX4, IFNG, FOXN1, CLDN1
2MP:00020068.8HR, GZMB, IFNG, FOXN1, AIRE
3MP:00053918.8AIRE, FOXN1, IFNG, ALX4, HR

Publications for Alopecia

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53PubMed
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Articles related to Alopecia:

(show top 50)    (show all 1583)
idTitleAuthorsYear
1
A study on the extracts of Cuscuta reflexa Roxb. in treatment of cyclophosphamide induced alopecia. (24393240)
2014
2
Congenital triangular alopecia. (24403390)
2014
3
Is more hair always better? A single biopsy specimen is preferred for the evaluation of alopecia. (24117846)
2014
4
Genetic analysis of interleukin-1 receptor antagonist and interleukin-1I^ single-nucleotide polymorphisms C-511T and C+3953T in alopecia areata: susceptibility and severity association. (23584371)
2013
5
Female pattern alopecia: current perspectives. (24039457)
2013
6
Alopecia areata associated with Herpes zoster. (23682830)
2013
7
Therapy for alopecia areata in mice using parathyroid hormone agonists and antagonists, linked to a collagen-binding domain. (24326563)
2013
8
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. (24019775)
2013
9
Alopecia areata - Vitiligo overlap syndrome: an emerging clinical variant. (23760330)
2013
10
Summary of the Preceding Three Alopecia Areata Research Summits: What's Past Is Prologue. (24326556)
2013
11
Diffuse neurofibroma - an uncommon cause of alopecia. (24346909)
2013
12
Growth hormone deficiency in a young patient with alopecia areata. (24326559)
2013
13
Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship? (23329992)
2012
14
The follicular triad: a pathological clue to the diagnosis of early frontal fibrosing alopecia. (21787366)
2012
15
General practitioners' knowledge and practices related to alopecia areata in Qassim region, Saudi Arabia. (22415332)
2012
16
Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. (22763785)
2012
17
Temporary alopecia after embolization of an arteriovenous malformation. (23031381)
2012
18
Association between scalp psoriasis and alopecia areata. (22535354)
2012
19
Cross-section Trichometry: A Clinical Tool for Assessing the Progression and Treatment Response of Alopecia. (23766610)
2012
20
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. (21272494)
2011
21
Investigative guidelines for alopecia areata. (21689240)
2011
22
Hair grooming practices and central centrifugal cicatricial alopecia. (19293007)
2009
23
Is Helicobacter pylori infection associated with alopecia areata? (19250167)
2009
24
Treatment of alopecia areata in children. (19685659)
2009
25
Compound heterozygous mutations in the vitamin D receptor in a patient with hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia. (19049339)
2009
26
Treatment of postmenopausal frontal fibrosing alopecia with oral dutasteride. (19539860)
2009
27
Alopecia areata is not associated with Helicobacter pylori. (20049262)
2009
28
Lack of efficacy of topical imiquimod in the treatment of patchy alopecia areata. (18986369)
2008
29
Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample. (18986440)
2008
30
Poor long term outcome of severe alopecia areata in children treated with high dose pulse corticosteroid therapy. (18279461)
2008
31
Autosomal-recessive syndrome with alopecia, hypogonadism, progressive extra-pyramidal disorder, white matter disease, sensory neural deafness, diabetes mellitus, and low IGF1. (17167799)
2007
32
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. (16914743)
2006
33
The alopecias associated with vitamin D-dependent rickets type IIA and with hairless gene mutations: a comparative clinical, histologic, and immunohistochemical study. (15781675)
2005
34
Androgenetic alopecia and current methods of treatment. (15818439)
2005
35
Association of a polymorphism in the ornithine decarboxylase gene with male androgenetic alopecia. (15761444)
2005
36
Vitamin D-dependent rickets Type II with alopecia: two case reports and review of the literature. (12956677)
2003
37
Androgenetic alopecia in men aged 40-69 years: prevalence and risk factors. (14674898)
2003
38
A mosaic pattern of alopecia in the oral-facial-digital syndrome type I (Papillon-LAcage and psaume syndrome). (10571835)
1999
39
Equine alopecia areata autoantibodies target multiple hair follicle antigens and may alter hair growth. A preliminary study. (9832317)
1998
40
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
41
Growth retardation, alopecia, pseudoanodontia, and optic atrophy (GAPO syndrome) with congenital glaucoma. (9230846)
1997
42
Guidelines of care for androgenetic alopecia. American Academy of Dermatology. (8784287)
1996
43
Alopecia universalis in liver transplant patients treated with cyclosporin. (7577610)
1995
44
Alopecia universalis as a single abnormality in an inbred Pakistani kindred. (8357006)
1993
45
Hormonal status in postmenopausal androgenetic alopecia. (1478763)
1992
46
Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice. (1536782)
1992
47
Alopecia in meralgia paresthetica. (3973115)
1985
48
Spontaneous cell-mediated cytotoxicity (SCMC) in patients with alopecia universalis. (6172934)
1981
49
Hyperkeratotic follicular plugging with alopecia totalis. (13774268)
1961
50
Alopecia totalis associated with onychodystrophy. (21065789)
1946

Variations for Alopecia

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Expression for genes affiliated with Alopecia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alopecia

Search GEO for disease gene expression data for Alopecia.

Pathways for genes affiliated with Alopecia

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51PathCards, 55R&D Systems, 39NCBI BioSystems Database
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Pathways related to Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GZMB, IFNG
2
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.7GZMB, IFNG
3
Show member pathways
9.7GZMB, IFNG

Compounds for genes affiliated with Alopecia

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46Novoseek, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 12DrugBank, 3BitterDB
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Compounds related to Alopecia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide4610.0GZMB, IFNG
217-hydroxypregnenolone4610.0SHBG, CYP21A2
311 deoxycortisol4610.0SHBG, CYP21A2
4leuprolide acetate469.9SHBG, CYP21A2
5clomiphene citrate469.9CYP21A2, SHBG
63-alpha-androstanediol glucuronide46 2510.9SHBG, CYP21A2
7concanamycin a46 6210.9IFNG, GZMB
817-hydroxyprogesterone46 2510.9CYP21A2, SHBG
9spironolactone46 62 30 52 1213.8SHBG, CYP21A2
10ivig469.7GZMB, IFNG
11ketoconazole46 30 25 1212.7CYP21A2, SHBG
12hydrocortisone46 3 62 1212.7CYP21A2, SHBG, IFNG
13dehydroepiandrosterone sulfate469.6CYP21A2, SHBG
14phenytoin46 52 30 1212.4SHBG, CYP21A2
15prednisolone46 30 1211.2GZMB, IFNG, SHBG, CYP21A2
16dexamethasone46 52 30 1212.0CYP21A2, SHBG, IFNG, GZMB
17arginine469.0CYP21A2, SHBG, IFNG, GZMB

GO Terms for genes affiliated with Alopecia

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17Gene Ontology
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Biological processes related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1humoral immune responseGO:0069599.9IFNG, AIRE
2hair follicle developmentGO:0019429.7ALX4, FOXN1

Products for genes affiliated with Alopecia

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Sources for Alopecia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet