MCID: ALP008
MIFTS: 60

Alopecia malady

Summaries for Alopecia

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Hair loss or baldness (technically known as alopecia) is a loss of hair from the head or body. Baldness... more...

MalaCards: Alopecia is related to alopecia areata and alopecia universalis. An important gene associated with Alopecia is HR (hair growth associated), and among its related pathways are Metabolism of steroid hormones and vitamin D and Androgen biosynthesis. The compounds androstenedione and dehydroepiandrosterone sulfate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Disease Ontology:8 A hypotrichosis that is characterized by a loss of hair from the head or body.

Description from OMIM:46 109200,300042

Aliases & Classifications for Alopecia

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8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 46OMIM, 27ICD9CM, 56SNOMED-CT, 60UMLS, 34MeSH, 39NCIt
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Aliases & Descriptions:

alopecia 8 20 22 10


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Disease Ontology8 DOID:987
ICD9CM27 704.0, 704.00
MeSH34 D000505
NCIt39 C50575

Related Diseases for Alopecia

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17GeneCards, 18GeneDecks
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Diseases related to Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 436)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia areata31.7IFNG, AIRE
2alopecia universalis31.2HR
3androgenic alopecia31.0SHBG, CYP21A2, SRD5A2, SRD5A1
4acne30.3SHBG
5hypothyroidism30.1INS, AIRE, SHBG
6hypogonadism30.1INS, SHBG
7diabetes mellitus30.1AIRE, SHBG, INS
8hyperandrogenism30.1CYP21A2, SHBG, INS, SRD5A1
9autoimmune thyroiditis30.1IFNG, AIRE, CYP21A2
10candidiasis30.1IFNG, AIRE
11graves' disease29.8AIRE, SHBG, IFNG, CYP21A2
12polycystic ovary syndrome29.6CYP21A2, SHBG, SRD5A1, INS
13hyperprolactinemia29.6SRD5A1, SHBG
14infertility29.6INS, CYP21A2, SHBG
15cryptorchidism29.6SHBG, SRD5A1
16adrenoleukodystrophy29.6CYP21A2
17impotence29.6SRD5A1, SHBG
18diffuse alopecia areata10.4
19vitiligo10.4
20lupus erythematosus10.4
21psoriasis10.4
22telogen effluvium10.4
23follicular mucinosis10.4
24alopecia totalis10.3
25trichotillomania10.3
26dermatitis10.3
27lichen planus10.3
28thyroiditis10.3
29rickets10.3
30hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
31folliculitis10.2
32prostatitis10.2
33t-cell immunodeficiency, congenital alopecia and nail dystrophy10.2
34ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.2
35frontal fibrosing alopecia10.2
36hepatitis10.2
37congenital alopecia x-linked10.2
38thumb deformity, alopecia, pigmentation anomaly10.2
39alopecia-intellectual deficit syndrome10.2
40cronkhite-canada syndrome10.2
41syphilis10.2
42central centrifugal cicatricial alopecia10.2
43autosomal recessive palmoplantar keratoderma and congenital alopecia10.2
44crohn's disease10.1
45hepatitis c10.1
46secondary syphilis10.1
47prostate cancer10.1
48tinea capitis10.1
49alopecia mental retardation syndrome 210.1
50cataract, alopecia, sclerodactyly10.1

Graphical network of the top 20 diseases related to Alopecia:



Diseases related to alopecia

Clinical Features for Alopecia

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46OMIM
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Clinical features from OMIM:

109200,300042

Drugs & Therapeutics for Alopecia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Alopecia

Drug clinical trials:

Search ClinicalTrials for Alopecia

Search NIH Clinical Center for Alopecia

Search CenterWatch for Alopecia

Genetic Tests for Alopecia

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20GeneTests, 22GTR
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Genetic tests related to Alopecia:

id Genetic test Affiliating Genes
1 Alopecia20 22

Anatomical Context for Alopecia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Alopecia:

32
Skin, T cells, Thyroid, Prostate, Breast, Bone, Testes, Pituitary, Endothelial, Heart, Bone marrow, Tongue, Monocytes, Ovary, Liver, Lung, Thymus, Nk cells, Eye, Colon

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alopecia:
id TissueAnatomical CompartmentCell Relevance
1 HairHair FollicleFetal Hair Placode Cells Affected by disease
2 HairHair FollicleFetal Matrix Cells Affected by disease
3 DermisDermal PapillaGuard Dermal Papilla Cells Affected by disease
4 HairHair FolliclePrimary Hair Placode Cells Affected by disease

Animal Models for Alopecia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alopecia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.9FOXN1, AIRE, INS, HR, SRD5A1, SRD5A2
2MP:000537910.6SRD5A2, IFNG, FOXN1, AIRE, INS, HR

Publications for Alopecia

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50PubMed
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Articles related to Alopecia:

(show top 50)    (show all 1592)
idTitleAuthorsYear
1
Tinea capitis mimicking dissecting cellulitis of the scalp: a histopathologic pitfall when evaluating alopecia in the post-pubertal patient. (24329904)
2014
2
Alopecia due to common metabolic diseases. (23680253)
2013
3
Preventive effects of Monascus on androgen-related diseases: androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer. (23651036)
2013
4
Successful treatment of alopecia totalis with hydroxychloroquine: report of 2 cases. (23680203)
2013
5
Development of autoimmune hair loss disease alopecia areata is associated with cardiac dysfunction in C3H/HeJ mice. (23658656)
2013
6
Keratosis follicularis spinulosa decalvans: a rare cause of scarring alopecia in two young Indian girls. (23960394)
2013
7
What causes alopecia areata? (23947678)
2013
8
Impact of scalp cooling on chemotherapy-induced alopecia, wig use and hair growth of patients with cancer. (23571182)
2013
9
Dermoscopy guided scalp biopsy in cicatricial alopecia. (22449222)
2013
10
Familial frontal fibrosing alopecia. (22716508)
2013
11
Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship? (23329992)
2012
12
Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata. (21739260)
2012
13
Miniaturized Hairs Maintain Contact with the Arrector Pili Muscle in Alopecia Areata but not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth. (23180923)
2012
14
Current treatment strategies in pediatric alopecia areata. (23248364)
2012
15
RenbAPk phenomenon in a patient with alopecia areata universalis and psoriasis. (22150402)
2012
16
WITHDRAWN: Female Alopecia in Art. (22560126)
2012
17
Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia. (22692500)
2012
18
Investigative guidelines for alopecia areata. (21689240)
2011
19
Dermatologic therapy: Alopecia areata update. (21689237)
2011
20
Lupus erythematosus tumidus with discoid lupus erythematosus-induced alopecia of the scalp. (22031650)
2011
21
The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia. (21224180)
2011
22
Analysis of familial factors using the basic and specific (BASP) classification in Korean patients with androgenetic alopecia. (21453986)
2011
23
Connubial androgenetic alopecia. (22106127)
2011
24
Lipid peroxidation/antioxidant activity in patients with alopecia areata. (20629847)
2011
25
Dermoscopy patterns of cicatricial alopecia resulting from discoid lupus erythematosus and lichen planopilaris. (20520933)
2010
26
An uncontrolled, open label study of sulfasalazine in severe alopecia areata. (19171984)
2008
27
Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: better response in patients under 26 years old. (18363752)
2008
28
Subcutaneous efalizumab is not effective in the treatment of alopecia areata. (18280336)
2008
29
Does hair prevent acne? Insights from alopecia areata. (17459073)
2007
30
Frontal fibrosing alopecia. (16403378)
2005
31
Topical estrogen therapy for androgenetic alopecia in menopausal females. (15057016)
2004
32
Coeliac disease and alopecia areata in childhood. (12603809)
2003
33
Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. (12670724)
2003
34
Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. (12589427)
2003
35
Atrichia with papular lesions resulting from compound heterozygous mutations in the hairless gene: A lesson for differential diagnosis of alopecia universalis. (12271294)
2002
36
Androgenetic alopecia: the role of inflammation and Demodex. (11679010)
2001
37
An X-linked gene involved in androgenetic alopecia: a lesson to be learned from adrenoleukodystrophy. (10828629)
2000
38
SAHA syndrome: female androgenetic alopecia and hirsutism. (10439235)
1999
39
Selections from current literature: androgenetic alopecia: the science behind a new oral treatment. (9848437)
1998
40
Growth retardation, alopecia, pseudoanodontia, and optic atrophy (GAPO syndrome) with congenital glaucoma. (9230846)
1997
41
Diffuse alopecia of the scalp in borderline-lepromatous leprosy in an Indian patient. (9503871)
1997
42
Lymphocyte-mediated alopecia in C57BL/6 mice following successful immunotherapy for melanoma. (8823372)
1996
43
An allele of the interleukin-1 receptor antagonist as a genetic severity factor in alopecia areata. (7738374)
1995
44
Alopecia universalis in a patient seropositive for the human immunodeficiency virus. (8101531)
1993
45
Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia. (8496421)
1993
46
Acquired alopecia, mental retardation, short stature, microcephaly, and optic atrophy. (2246773)
1990
47
Alopecia universalis in identical twins. (6539757)
1984
48
An ectodermal dysplasia syndrome of alopecia, onychodysplasia, hypohidrosis, hyperkeratosis, deafness and other manifestations. (863459)
1977
49
Alopecia totalis, nail dysplasia and amelogenesis imperfecta. (1218220)
1975
50
Pseudopelade of Brocq: its relationship to some forms of cicatricial alopecias and to lichen planus. (14354293)
1955

Genetic Variations for Alopecia

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Expression for genes affiliated with Alopecia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alopecia

Search GEO for disease gene expression data for Alopecia.

Pathways for genes affiliated with Alopecia

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7SRD5A2, SRD5A1, CYP21A2
2
Hide members
10.6SRD5A2, SRD5A1

Compounds for genes affiliated with Alopecia

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44Novoseek, 24HMDB, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Alopecia according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1androstenedione44 2412.2SRD5A2, SRD5A1, INS, CYP21A2, SHBG
2dehydroepiandrosterone sulfate4411.2SHBG, CYP21A2, INS, SRD5A1
3dhea4411.1SRD5A1, INS, CYP21A2, SHBG
4hydrocortisone44 2 59 1114.1INS, CYP21A2, SHBG, IFNG
5dihydrotestosterone44 28 11 2414.1SHBG, CYP21A2, SRD5A1, SRD5A2
6desogestrel44 1112.1SHBG, INS, SRD5A1
7clomiphene citrate4411.1INS, CYP21A2, SHBG
8finasteride44 59 11 2414.1SHBG, SRD5A1, SRD5A2
9auranofin44 59 28 1114.1IFNG, SRD5A1, SRD5A2
103-alpha-androstanediol glucuronide44 2412.1SHBG, CYP21A2, SRD5A1
11cortisone44 2412.1CYP21A2, INS, SRD5A1
12cyproteroneacetate4411.1SHBG, INS, SRD5A1
13gnrh4411.1SHBG, CYP21A2, INS, SRD5A1
1417-hydroxyprogesterone44 2412.1SRD5A1, CYP21A2, SHBG
15spironolactone49 44 59 28 1115.1SHBG, CYP21A2, SRD5A1
163beta-hydroxysteroid4411.0SRD5A2, SRD5A1, CYP21A2
1717beta-hydroxysteroid4411.0CYP21A2, SRD5A1, SRD5A2
18ketoconazole44 28 11 2414.0SHBG, CYP21A2, SRD5A1
19phenytoin44 49 28 1114.0SRD5A1, CYP21A2, SHBG
20es 9365911.0SRD5A2, SRD5A1
21testosterone44 59 11 2414.0SRD5A2, SRD5A1, INS, CYP21A2, SHBG
22c-peptide4411.0SHBG, CYP21A2, INS
23epitestosterone4411.0SRD5A1, SHBG
24ment4411.0SHBG, SRD5A1
25formestane4411.0SHBG, SRD5A1
26enterolactone4411.0SHBG, SRD5A1
27dutasteride44 1111.9SRD5A2, SRD5A1
28norgestimate44 1111.9SRD5A1, SHBG
295alpha-dihydroprogesterone4410.9SRD5A2, SRD5A1
30androstenediol4410.9SRD5A1, SHBG
31oxandrolone44 1111.9INS, SHBG
32androstanedione44 11 2412.9SRD5A1, SRD5A2
3317-hydroxypregnenolone4410.9CYP21A2, SHBG
34acarbose44 1111.9INS, SHBG
35doca4410.9CYP21A2, SRD5A1
3611 deoxycortisol4410.9SHBG, CYP21A2
37goserelin44 28 1112.8SHBG, SRD5A1
38allopregnanolone4410.8SHBG, SRD5A1
39dexamethasone44 49 28 1113.8SRD5A1, INS, CYP21A2, SHBG, IFNG
405alpha-androstane-3alpha,17beta-diol4410.8SRD5A1, SHBG
41hydroxyflutamide44 2811.7SRD5A1, SHBG
42prednisolone44 28 1112.7IFNG, SHBG, CYP21A2
43leuprolide acetate4410.7CYP21A2, SHBG
44androsterone glucuronide44 2411.6SRD5A1, SHBG
45exemestane49 44 59 1113.5SHBG, SRD5A1
46estradiol44 11 2412.4SRD5A2, SRD5A1, CYP21A2, SHBG

GO Terms for genes affiliated with Alopecia

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16Gene Ontology
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Biological processes related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen biosynthetic processGO:00670210.6SRD5A2, SRD5A1
2steroid metabolic processGO:00820210.4SRD5A2, SRD5A1, CYP21A2

Molecular functions related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholestenone 5-alpha-reductase activityGO:04775110.6SRD5A2, SRD5A1
23-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2, SRD5A1

Products for genes affiliated with Alopecia

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Sources for Alopecia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet