MCID: ALP008
MIFTS: 59

Alopecia malady

Summaries for Alopecia

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Hair loss or baldness (technically known as alopecia) is a loss of hair from the head or body. Baldness... more...

MalaCards: Alopecia is related to alopecia areata and alopecia universalis. An important gene associated with Alopecia is HR (hair growth associated), and among its related pathways are Metabolism of steroid hormones and vitamin D and Androgen biosynthesis. The compounds androstenedione and dehydroepiandrosterone sulfate have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Disease Ontology:8 A hypotrichosis that is characterized by a loss of hair from the head or body.

Description from OMIM:47 109200,300042

Aliases & Classifications for Alopecia

Sources:
8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 47OMIM, 27ICD9CM, 57SNOMED-CT, 61UMLS, 35MeSH, 40NCIt
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Aliases & Descriptions:

alopecia 8 20 22 10


External Ids:

Disease Ontology8 DOID:987
ICD9CM27 704.0, 704.00
MeSH35 D000505
NCIt40 C50575

Related Diseases for Alopecia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 425)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia areata31.7AIRE, IFNG
2alopecia universalis31.3HR
3androgenic alopecia30.8SHBG, CYP21A2, SRD5A1, SRD5A2
4acne30.3SHBG
5insulin resistance30.3SHBG, CYP21A2, INS
6hyperandrogenism30.1SHBG, CYP21A2, INS, SRD5A1
7mental retardation30.0SHBG
8short stature29.9SHBG, CYP21A2, INS
9graves' disease29.8IFNG, SHBG, AIRE, CYP21A2
10autoimmune thyroiditis29.8CYP21A2, AIRE, IFNG
11polycystic ovary syndrome29.6SHBG, CYP21A2, INS, SRD5A1
12hyperprolactinemia29.6SHBG, SRD5A1
13infertility29.6SHBG, CYP21A2, INS
14cryptorchidism29.6SHBG, SRD5A1
15adrenoleukodystrophy29.6CYP21A2
16alopecia totalis10.7
17frontal fibrosing alopecia10.7
18central centrifugal cicatricial alopecia10.5
19diffuse alopecia areata10.5
20vitiligo10.4
21telogen effluvium10.4
22follicular mucinosis10.4
23trichotillomania10.3
24lichen planus10.3
25discoid lupus erythematosus10.3
26rickets10.3
27hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
28folliculitis10.3
29t-cell immunodeficiency, congenital alopecia and nail dystrophy10.3
30ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.3
31n syndrome10.2
32hepatitis a10.2
33alopecia immunodeficiency10.2
34thumb deformity, alopecia, pigmentation anomaly10.2
35alopecia-intellectual deficit syndrome10.2
36cronkhite-canada syndrome10.2
37syphilis10.2
38congenital alopecia x-linked10.2
39ichthyosis, follicular10.2
40secondary syphilis10.2
41tinea capitis10.2
42cataract, alopecia, sclerodactyly10.2
43gapo syndrome10.2
44alopecia areata 210.2
45alopecia areata 110.2
46autosomal recessive palmoplantar keratoderma and congenital alopecia10.2
47atopic dermatitis10.1
48mycosis fungoides10.1
49alopecia contractures dwarfism mental retardation10.1
50alopecia congenita keratosis palmoplantaris10.1

Graphical network of the top 20 diseases related to Alopecia:



Diseases related to alopecia

Clinical Features for Alopecia

Sources:
47OMIM
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Clinical features from OMIM:

109200,300042

Drugs & Therapeutics for Alopecia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Alopecia

Drug clinical trials:

Search ClinicalTrials for Alopecia

Search NIH Clinical Center for Alopecia

Search CenterWatch for Alopecia

Genetic Tests for Alopecia

Sources:
20GeneTests, 22GTR
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Genetic tests related to Alopecia:

id Genetic test Affiliating Genes
1 Alopecia20 22

Anatomical Context for Alopecia

Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Alopecia:

33
Skin, Ovary, Liver, Tongue, Brain, Lung, Bone marrow, Thymus, Heart, Small intestine, Colon, Thyroid, Adrenal gland, Breast, Prostate, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Pancreatic islet, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alopecia:
id TissueAnatomical CompartmentCell Relevance
1 HairHair FollicleFetal Hair Placode Cells Affected by disease
2 HairHair FollicleFetal Matrix Cells Affected by disease
3 DermisDermal PapillaGuard Dermal Papilla Cells Affected by disease
4 HairHair FolliclePrimary Hair Placode Cells Affected by disease

Animal Models for Alopecia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Alopecia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.9FOXN1, AIRE, INS, HR, SRD5A1, SRD5A2
2MP:000537910.6SRD5A2, IFNG, FOXN1, AIRE, INS, HR

Publications for Alopecia

Sources:
51PubMed
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Articles related to Alopecia:

(show top 50)    (show all 1593)
idTitleAuthorsYear
1
Pulse methylprednisolone therapy for the treatment of extensive alopecia areata. (23336179)
2014
2
Recurrent spontaneous abortions, Hashimoto thyroiditis and alopecia totalis: response to anticoagulation and intravenous immunoglobulin therapy. (24308767)
2014
3
Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia. (24351010)
2014
4
Early stage alopecia areata is associated with inflammation in the upper dermis and damage to the hair follicle infundibulum. (23808570)
2013
5
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (24025145)
2013
6
Partial reversal of androgenetic alopecia with methotrexate therapy for psoriasis. (24153140)
2013
7
Androgenetic alopecia (male pattern hair loss) in the United States: what treatments should primary care providers recommend? (24170634)
2013
8
Microarray analysis of androgenetic and senescent alopecia: comparison of gene expression shows two distinct profiles. (23886704)
2013
9
Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology. (24001790)
2013
10
Alopecia due to cancer. (24049314)
2013
11
A comparison of men and women's experiences of chemotherapy-induced alopecia. (22901547)
2013
12
Retinoids putting the "a" in alopecia. (23318784)
2013
13
A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study. (23960389)
2013
14
Topical immunotherapy with diphenylcyclopropenone of patients with alopecia areata--a large retrospective study on 142 patients with a self-controlled design. (21569118)
2012
15
Alopecia in an ophiasis pattern: traction alopecia versus alopecia areata. (22768432)
2012
16
Efficacy and safety of oral mega pulse methylprednisolone for severe therapy resistant Alopecia areata. (22426909)
2012
17
Interest of high-dose pulse corticosteroid therapy combined with methotrexate for severe alopecia areata: a retrospective case series. (22738995)
2012
18
Concomitant presentation of alopecia areata in siblings: a rare occurrence. (23180915)
2012
19
Frontal fibrosing alopecia: a review of eleven patients. (21697058)
2011
20
Alopecia areata: Clinical presentation, diagnosis, and unusual cases. (21689244)
2011
21
Renbok phenomenon between psoriasis and alopecia areata. (21623882)
2011
22
Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. (21206086)
2011
23
Palmoplantar keratoderma, pseudo-ainhum, and universal atrichia: A new patient and review of the palmoplantar keratoderma-congenital alopecia syndrome. (20635335)
2010
24
Serum levels of IL-18 and sIL-2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids. (19758343)
2010
25
Frontal fibrosing alopecia associated with generalized hair loss. (20695856)
2010
26
Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor. (19815438)
2010
27
Is Helicobacter pylori infection associated with alopecia areata? (19250167)
2009
28
Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia? (20300369)
2009
29
The efficacy of topical diphencyprone in the treatment of alopecia areata. (20049283)
2009
30
Androgenetic alopecia and insulin resistance in young men. (19094069)
2009
31
Alopecia areata during etanercept therapy. (19412875)
2009
32
An unusual anatomical colocalization of alopecia areata and vitiligo in a child, and improvement during treatment with topical prostaglandin E2. (20055821)
2009
33
Biologic agents and alopecia areata. (19018127)
2009
34
Sarcoidal alopecia as a mimic of discoid lupus erythematosus. (18378353)
2008
35
Dermoscopy findings of alopecia areata in an African-American patient. (21886714)
2008
36
In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101. (15953089)
2005
37
Androgenetic alopecia in children: report of 20 cases. (15787828)
2005
38
Interleukin-16 in patients with alopecia areata. (15619436)
2005
39
A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia. (12403843)
2002
40
A retrospective study on the characteristics of androgenetic alopecia among Asian races in the National Skin Centre, a tertiary dermatological referral centre in Singapore. (12520829)
2002
41
A clinicopathologic study of scarring alopecia due to lichen planus: comparison with scarring alopecia in discoid lupus erythematosus and pseudopelade. (10446772)
1999
42
Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice. (10674367)
1999
43
Tufted hair folliculitis: a pattern of scarring alopecia? (10411422)
1999
44
Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men and postmenopausal women. (10674382)
1999
45
Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. (9777765)
1998
46
A case of alopecia universalis without the involvement of scalp hairs. (7740842)
1995
47
A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia. (7923828)
1994
48
Alopecia universalis as a single abnormality in an inbred Pakistani kindred. (8357006)
1993
49
Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice. (1536782)
1992
50
Otorhinophyma, pruritus and alopecia totalis syndrome; response to testosterone. (20262878)
1947

Genetic Variations for Alopecia

Expression for genes affiliated with Alopecia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alopecia

Search GEO for disease gene expression data for Alopecia.

Pathways for genes affiliated with Alopecia

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7SRD5A2, SRD5A1, CYP21A2
2
Hide members
10.6SRD5A2, SRD5A1

Compounds for genes affiliated with Alopecia

Sources:
45Novoseek, 24HMDB, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB
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Compounds related to Alopecia according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1androstenedione45 2412.2SRD5A2, SRD5A1, INS, CYP21A2, SHBG
2dehydroepiandrosterone sulfate4511.2SHBG, CYP21A2, INS, SRD5A1
3dhea4511.1SRD5A1, INS, CYP21A2, SHBG
4hydrocortisone45 2 60 1114.1INS, CYP21A2, SHBG, IFNG
5dihydrotestosterone45 29 11 2414.1SHBG, CYP21A2, SRD5A1, SRD5A2
6desogestrel45 1112.1SHBG, INS, SRD5A1
7clomiphene citrate4511.1INS, CYP21A2, SHBG
8finasteride45 60 11 2414.1SHBG, SRD5A1, SRD5A2
9auranofin45 60 29 1114.1IFNG, SRD5A1, SRD5A2
103-alpha-androstanediol glucuronide45 2412.1SHBG, CYP21A2, SRD5A1
11cortisone45 2412.1CYP21A2, INS, SRD5A1
12cyproteroneacetate4511.1SHBG, INS, SRD5A1
13gnrh4511.1SHBG, CYP21A2, INS, SRD5A1
1417-hydroxyprogesterone45 2412.1SRD5A1, CYP21A2, SHBG
15spironolactone50 45 60 29 1115.1SHBG, CYP21A2, SRD5A1
163beta-hydroxysteroid4511.0SRD5A2, SRD5A1, CYP21A2
1717beta-hydroxysteroid4511.0CYP21A2, SRD5A1, SRD5A2
18ketoconazole45 29 11 2414.0SHBG, CYP21A2, SRD5A1
19phenytoin45 50 29 1114.0SRD5A1, CYP21A2, SHBG
20es 9366011.0SRD5A2, SRD5A1
21testosterone45 60 11 2414.0SRD5A2, SRD5A1, INS, CYP21A2, SHBG
22c-peptide4511.0SHBG, CYP21A2, INS
23epitestosterone4511.0SRD5A1, SHBG
24ment4511.0SHBG, SRD5A1
25formestane4511.0SHBG, SRD5A1
26enterolactone4511.0SHBG, SRD5A1
27dutasteride45 1111.9SRD5A2, SRD5A1
28norgestimate45 1111.9SRD5A1, SHBG
295alpha-dihydroprogesterone4510.9SRD5A2, SRD5A1
30androstenediol4510.9SRD5A1, SHBG
31oxandrolone45 1111.9INS, SHBG
32androstanedione45 11 2412.9SRD5A1, SRD5A2
3317-hydroxypregnenolone4510.9CYP21A2, SHBG
34acarbose45 1111.9INS, SHBG
35doca4510.9CYP21A2, SRD5A1
3611 deoxycortisol4510.9SHBG, CYP21A2
37goserelin45 29 1112.8SHBG, SRD5A1
38allopregnanolone4510.8SHBG, SRD5A1
39dexamethasone45 50 29 1113.8SRD5A1, INS, CYP21A2, SHBG, IFNG
405alpha-androstane-3alpha,17beta-diol4510.8SRD5A1, SHBG
41hydroxyflutamide45 2911.7SRD5A1, SHBG
42prednisolone45 29 1112.7IFNG, SHBG, CYP21A2
43leuprolide acetate4510.7CYP21A2, SHBG
44androsterone glucuronide45 2411.6SRD5A1, SHBG
45exemestane50 45 60 1113.5SHBG, SRD5A1
46estradiol45 11 2412.4SRD5A2, SRD5A1, CYP21A2, SHBG

GO Terms for genes affiliated with Alopecia

Sources:
16Gene Ontology
See all sources

Biological processes related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen biosynthetic processGO:00670210.6SRD5A2, SRD5A1
2steroid metabolic processGO:00820210.4SRD5A2, SRD5A1, CYP21A2

Molecular functions related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholestenone 5-alpha-reductase activityGO:04775110.6SRD5A2, SRD5A1
23-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2, SRD5A1

Products for genes affiliated with Alopecia

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Sources for Alopecia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet