MCID: ALP008
MIFTS: 60

Alopecia malady

Summaries for Alopecia

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Hair loss or baldness (technically known as alopecia) is a loss of hair from the head or body. Baldness... more...

MalaCards: Alopecia is related to alopecia areata and alopecia universalis. An important gene associated with Alopecia is HR (hair growth associated), and among its related pathways are Metabolism of steroid hormones and vitamin D and Androgen biosynthesis. The compounds androstenedione and dehydroepiandrosterone sulfate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Disease Ontology:8 A hypotrichosis that is characterized by a loss of hair from the head or body.

Description from OMIM:46 109200,300042

Aliases & Classifications for Alopecia

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8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 46OMIM, 27ICD9CM, 56SNOMED-CT, 60UMLS, 34MeSH, 39NCIt
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Aliases & Descriptions:

alopecia 8 20 22 10


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Disease Ontology8 DOID:987
ICD9CM27 704.0, 704.00
MeSH34 D000505
NCIt39 C50575

Related Diseases for Alopecia

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17GeneCards, 18GeneDecks
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Diseases related to Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 436)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia areata31.7IFNG, AIRE
2alopecia universalis31.2HR
3androgenic alopecia31.0SHBG, CYP21A2, SRD5A2, SRD5A1
4acne30.3SHBG
5hypothyroidism30.1INS, AIRE, SHBG
6hypogonadism30.1INS, SHBG
7diabetes mellitus30.1AIRE, SHBG, INS
8hyperandrogenism30.1CYP21A2, SHBG, INS, SRD5A1
9autoimmune thyroiditis30.1IFNG, AIRE, CYP21A2
10candidiasis30.1IFNG, AIRE
11graves' disease29.8AIRE, SHBG, IFNG, CYP21A2
12polycystic ovary syndrome29.6CYP21A2, SHBG, SRD5A1, INS
13hyperprolactinemia29.6SRD5A1, SHBG
14infertility29.6INS, CYP21A2, SHBG
15cryptorchidism29.6SHBG, SRD5A1
16adrenoleukodystrophy29.6CYP21A2
17impotence29.6SRD5A1, SHBG
18diffuse alopecia areata10.4
19vitiligo10.4
20lupus erythematosus10.4
21psoriasis10.4
22telogen effluvium10.4
23follicular mucinosis10.4
24alopecia totalis10.3
25trichotillomania10.3
26dermatitis10.3
27lichen planus10.3
28thyroiditis10.3
29rickets10.3
30hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
31folliculitis10.2
32prostatitis10.2
33t-cell immunodeficiency, congenital alopecia and nail dystrophy10.2
34ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.2
35frontal fibrosing alopecia10.2
36hepatitis10.2
37congenital alopecia x-linked10.2
38thumb deformity, alopecia, pigmentation anomaly10.2
39alopecia-intellectual deficit syndrome10.2
40cronkhite-canada syndrome10.2
41syphilis10.2
42central centrifugal cicatricial alopecia10.2
43autosomal recessive palmoplantar keratoderma and congenital alopecia10.2
44crohn's disease10.1
45hepatitis c10.1
46secondary syphilis10.1
47prostate cancer10.1
48tinea capitis10.1
49alopecia mental retardation syndrome 210.1
50cataract, alopecia, sclerodactyly10.1

Graphical network of the top 20 diseases related to Alopecia:



Diseases related to alopecia

Clinical Features for Alopecia

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46OMIM
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Clinical features from OMIM:

109200,300042

Drugs & Therapeutics for Alopecia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Alopecia

Drug clinical trials:

Search ClinicalTrials for Alopecia

Search NIH Clinical Center for Alopecia

Search CenterWatch for Alopecia

Genetic Tests for Alopecia

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20GeneTests, 22GTR
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Genetic tests related to Alopecia:

id Genetic test Affiliating Genes
1 Alopecia20 22

Anatomical Context for Alopecia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Alopecia:

32
Skin, T cells, Thyroid, Prostate, Breast, Bone, Testes, Pituitary, Endothelial, Heart, Bone marrow, Tongue, Monocytes, Ovary, Liver, Lung, Thymus, Nk cells, Eye, Colon

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alopecia:
id TissueAnatomical CompartmentCell Relevance
1 HairHair FollicleFetal Hair Placode Cells Affected by disease
2 HairHair FollicleFetal Matrix Cells Affected by disease
3 DermisDermal PapillaGuard Dermal Papilla Cells Affected by disease
4 HairHair FolliclePrimary Hair Placode Cells Affected by disease

Animal Models for Alopecia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alopecia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.9FOXN1, AIRE, INS, HR, SRD5A1, SRD5A2
2MP:000537910.6SRD5A2, IFNG, FOXN1, AIRE, INS, HR

Publications for Alopecia

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50PubMed
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Articles related to Alopecia:

(show top 50)    (show all 1592)
idTitleAuthorsYear
1
Sleep quality in patients with alopecia areata: questionnaire-based study. (23451837)
2014
2
Alopecia in a patient with Vogt-Koyanagi-Harada disease. (24433176)
2014
3
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. (24019775)
2013
4
Successful management of imatinib despite alopecia and nail necrosis. (23419836)
2013
5
Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata. (24194967)
2013
6
The current state of play in the histopathologic assessment of alopecia: two for one or one for two? (23899265)
2013
7
Severe refractory scarring alopecia associated with combinational use of ficlatuzumab (AV-299) and gefitinib. (23715581)
2013
8
Alopecia areata: more than skin deep. (24383154)
2013
9
Alopecia and Hypotrichosis as Characteristic Findings in Woodhouse-Sakati Syndrome: Report of a Family with Mutation in the C2orf37 Gene. (24015686)
2013
10
Is hair transplantation indicated in frontal fibrosing alopecia? The results of test grafting in three patients. (23631596)
2013
11
Early-onset alopecia and amyotrophic lateral sclerosis: a cohort study. (23942216)
2013
12
The experience of chemotherapy-induced alopecia for Australian women with ovarian cancer. (23528018)
2013
13
Genetic basis of alopecia areata: a roadmap for translational research. (23159180)
2013
14
Health status, coping strategies, and alexithymia in subjects with androgenetic alopecia: a questionnaire study. (23413102)
2013
15
Chemotherapy-induced alopecia: a cool to action. (23899727)
2013
16
Alopecia mucinosa responding to antileprosy treatment: are we missing something? (23723476)
2013
17
Many paths to alopecia via compromised regeneration of hair follicle stem cells. (23673497)
2013
18
Factors influencing the effectiveness of scalp cooling in the prevention of chemotherapy-induced alopecia. (23650021)
2013
19
Re: Androgenetic alopecia as an early marker of benign prostatic hyperplasia. (23059232)
2012
20
The comparison of treatment with clobetasol propionate 0.05% and topical pimecrolimus 1% treatment in the treatment of alopecia areata. (21787210)
2012
21
A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. (22116824)
2012
22
Linear lupus panniculitis of the scalp presenting as alopecia along Blaschko's lines: a distinct variant of lupus panniculitis in East Asians? (22220763)
2012
23
Photoletter to the editor: Scarring alopecia resulting from pyoderma gangrenosum of the scalp. (22514589)
2012
24
What's new in the histologic evaluation of alopecia and hair-related disorders? (23021054)
2012
25
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. (21272494)
2011
26
Randomized comparison of topical betamethasone valerate foam, intralesional triamcinolone acetonide and tacrolimus ointment in management of localized alopecia areata. (21769231)
2011
27
Reflectance confocal microscopy of the yellow dot pattern in alopecia areata. (21242396)
2011
28
Hair shaft abnormalities in alopecia areata evaluated by optical coherence tomography. (21241369)
2011
29
Psoriatic alopecia/alopecia areata-like reactions secondary to anti-tumor necrosis factor-I+ therapy: a novel cause of noncicatricial alopecia. (21317611)
2011
30
Treatment effects of intradermal botulinum toxin type A injection on alopecia areata. (21134049)
2010
31
A potential association between alopecia areata and narcolepsy. (20566938)
2010
32
Male androgenetic alopecia: population-based study in 1,005 subjects. (20927235)
2009
33
Tinea capitis mimicking cicatricial alopecia: what host and dermatophyte factors lead to this unusual clinical presentation? (19231646)
2009
34
Poor long term outcome of severe alopecia areata in children treated with high dose pulse corticosteroid therapy. (18279461)
2008
35
Alopecia universalis associated with impaired interleukin-4 production and low serum IgE level. (17637364)
2007
36
Frontal fibrosing alopecia presenting with components of Piccardi-Lassueur-Graham-Little syndrome. (17637362)
2007
37
Hirsutism, postpartum telogen effluvium, and male pattern alopecia. (17173578)
2006
38
Extensive alopecia areata treated with betamethasone oral mini-pulse therapy: an open uncontrolled study. (17642661)
2004
39
Pilot study of a novel treatment for androgenetic alopecia using enriched cell culture medium: clinical trials. (12639462)
2003
40
Finasteride increases anagen hair in men with androgenetic alopecia. (11069460)
2000
41
Successful treatment of alopecia areata-like hair loss with the contact sensitizer squaric acid dibutylester (SADBE) in C3H/HeJ mice. (10417620)
1999
42
The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. (10674369)
1999
43
Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. (9421466)
1998
44
The moth-eaten alopecia of secondary syphilis. A histopathological study of 12 patients. (8600781)
1995
45
Chronic alopecia. Trichotillomania. (7778928)
1995
46
Alopecia in a 19-month-old boy. Monilethrix. (8053707)
1994
47
Induction of hair growth in alopecia totalis with diphencyprone sensitization. (2598490)
1989
48
Natural killer cell and cytotoxic/suppressor T cell deficiency in peripheral blood in subjects with alopecia areata. (3250436)
1988
49
Testosterone metabolism in the skin. A review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens. (128323)
1975
50
Chronic mucocutaneous candidiasis and alopecia areata. (4706468)
1973

Genetic Variations for Alopecia

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Expression for genes affiliated with Alopecia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alopecia

Search GEO for disease gene expression data for Alopecia.

Pathways for genes affiliated with Alopecia

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7SRD5A2, SRD5A1, CYP21A2
2
Hide members
10.6SRD5A2, SRD5A1

Compounds for genes affiliated with Alopecia

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44Novoseek, 24HMDB, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Alopecia according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1androstenedione44 2412.2SRD5A2, SRD5A1, INS, CYP21A2, SHBG
2dehydroepiandrosterone sulfate4411.2SHBG, CYP21A2, INS, SRD5A1
3dhea4411.1SRD5A1, INS, CYP21A2, SHBG
4hydrocortisone44 2 59 1114.1INS, CYP21A2, SHBG, IFNG
5dihydrotestosterone44 28 11 2414.1SHBG, CYP21A2, SRD5A1, SRD5A2
6desogestrel44 1112.1SHBG, INS, SRD5A1
7clomiphene citrate4411.1INS, CYP21A2, SHBG
8finasteride44 59 11 2414.1SHBG, SRD5A1, SRD5A2
9auranofin44 59 28 1114.1IFNG, SRD5A1, SRD5A2
103-alpha-androstanediol glucuronide44 2412.1SHBG, CYP21A2, SRD5A1
11cortisone44 2412.1CYP21A2, INS, SRD5A1
12cyproteroneacetate4411.1SHBG, INS, SRD5A1
13gnrh4411.1SHBG, CYP21A2, INS, SRD5A1
1417-hydroxyprogesterone44 2412.1SRD5A1, CYP21A2, SHBG
15spironolactone49 44 59 28 1115.1SHBG, CYP21A2, SRD5A1
163beta-hydroxysteroid4411.0SRD5A2, SRD5A1, CYP21A2
1717beta-hydroxysteroid4411.0CYP21A2, SRD5A1, SRD5A2
18ketoconazole44 28 11 2414.0SHBG, CYP21A2, SRD5A1
19phenytoin44 49 28 1114.0SRD5A1, CYP21A2, SHBG
20es 9365911.0SRD5A2, SRD5A1
21testosterone44 59 11 2414.0SRD5A2, SRD5A1, INS, CYP21A2, SHBG
22c-peptide4411.0SHBG, CYP21A2, INS
23epitestosterone4411.0SRD5A1, SHBG
24ment4411.0SHBG, SRD5A1
25formestane4411.0SHBG, SRD5A1
26enterolactone4411.0SHBG, SRD5A1
27dutasteride44 1111.9SRD5A2, SRD5A1
28norgestimate44 1111.9SRD5A1, SHBG
295alpha-dihydroprogesterone4410.9SRD5A2, SRD5A1
30androstenediol4410.9SRD5A1, SHBG
31oxandrolone44 1111.9INS, SHBG
32androstanedione44 11 2412.9SRD5A1, SRD5A2
3317-hydroxypregnenolone4410.9CYP21A2, SHBG
34acarbose44 1111.9INS, SHBG
35doca4410.9CYP21A2, SRD5A1
3611 deoxycortisol4410.9SHBG, CYP21A2
37goserelin44 28 1112.8SHBG, SRD5A1
38allopregnanolone4410.8SHBG, SRD5A1
39dexamethasone44 49 28 1113.8SRD5A1, INS, CYP21A2, SHBG, IFNG
405alpha-androstane-3alpha,17beta-diol4410.8SRD5A1, SHBG
41hydroxyflutamide44 2811.7SRD5A1, SHBG
42prednisolone44 28 1112.7IFNG, SHBG, CYP21A2
43leuprolide acetate4410.7CYP21A2, SHBG
44androsterone glucuronide44 2411.6SRD5A1, SHBG
45exemestane49 44 59 1113.5SHBG, SRD5A1
46estradiol44 11 2412.4SRD5A2, SRD5A1, CYP21A2, SHBG

GO Terms for genes affiliated with Alopecia

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16Gene Ontology
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Biological processes related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen biosynthetic processGO:00670210.6SRD5A2, SRD5A1
2steroid metabolic processGO:00820210.4SRD5A2, SRD5A1, CYP21A2

Molecular functions related to Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholestenone 5-alpha-reductase activityGO:04775110.6SRD5A2, SRD5A1
23-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2, SRD5A1

Products for genes affiliated with Alopecia

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Sources for Alopecia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet