MCID: ALP008
MIFTS: 51

Alopecia malady

Genetic diseases (common) category

Summaries for Alopecia

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Disease Ontology:9 A hypotrichosis that is characterized by a loss of hair from the head or body.

MalaCards based summary: Alopecia is related to alopecia universalis and alopecia areata, and has symptoms including abnormality of the eye, abnormality of the skin and alopecia. An important gene associated with Alopecia is HR (hair growth associated), and among its related pathways are Th17 Differentiation and Downstream signaling in naive CD8+ T cells. The compounds alpha-galactosylceramide and 17-hydroxypregnenolone have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and t cells, and related mouse phenotypes are integument and tumorigenesis.

Aliases & Classifications for Alopecia

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Alopecia, Aliases & Descriptions:

Name: Alopecia 30 9 20 11 22


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

Disease Ontology9 DOID:987
ICD9CM27 704.00, 704.0
NCIt38 C50575
MeSH33 D000505

Related Diseases for Alopecia

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Diseases related to Alopecia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 498)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia universalis32.1HR
2alopecia areata31.7IFNG, AIRE, GZMB
3acne30.9SHBG
4alopecia, androgenetic, 130.9CYP21A2, SHBG
5myasthenia gravis30.5AIRE, IFNG
6candidiasis30.5IFNG, AIRE
7hypothyroidism30.4AIRE, SHBG
8hypogonadism30.4SHBG
9hyperandrogenism30.2CYP21A2, SHBG
10turner syndrome30.0SHBG, CYP21A2
11polycystic ovary syndrome30.0CYP21A2, SHBG
12hashimoto thyroiditis29.7AIRE, CYP21A2, IFNG
13male infertility29.7CYP21A2, SHBG
14aplastic anemia29.7IFNG, GZMB
15celiac disease29.6CYP21A2, GZMB
16cutaneous t cell lymphoma29.6IFNG, GZMB
17graves' disease29.6AIRE, CYP21A2, SHBG, IFNG
18alopecia totalis10.8
19frontal fibrosing alopecia10.7
20androgenic alopecia10.6
21central centrifugal cicatricial alopecia10.5
22t-cell immunodeficiency, congenital alopecia, and nail dystrophy10.4
23psoriasis10.4
24cataract, alopecia, sclerodactyly10.4
25lupus erythematosus10.4
26telogen effluvium10.4
27follicular mucinosis10.4
28dermatitis10.4
29trichotillomania10.4
30thyroiditis10.4
31alopecia-mental retardation syndrome 110.4
32ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis10.4
33lichen planus10.4
34rickets10.4
35discoid lupus erythematosus10.4
36diffuse alopecia areata10.3
37prostatitis10.3
38congenital alopecia x-linked10.3
39hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome10.3
40blindness10.3
41folliculitis10.3
42alopecia, epilepsy, pyorrhea, mental subnormality10.3
43ichthyosis alopecia eclabion ectropion mental retardation10.3
44alopecia contractures dwarfism mental retardation10.3
45gapo syndrome10.3
46alopecia-mental retardation syndrome 210.3
47hepatitis10.3
48tinea capitis10.3
49rasmussen encephalitis10.3GZMB
50macrocephaly, alopecia, cutis laxa, and scoliosis10.2

Graphical network of the top 20 diseases related to Alopecia:



Diseases related to alopecia

Symptoms for Alopecia

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HPO human phenotypes related to Alopecia:

id Description Frequency HPO Source Accession
1 abnormality of the eye hallmark (90%) HP:0000478
2 abnormality of the skin hallmark (90%) HP:0000951
3 alopecia hallmark (90%) HP:0001596
4 aplasia/hypoplasia of the eyebrow hallmark (90%) HP:0100840

Drugs & Therapeutics for Alopecia

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Drug clinical trials:

Search ClinicalTrials for Alopecia

Search NIH Clinical Center for Alopecia

Genetic Tests for Alopecia

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Genetic tests related to Alopecia:

id Genetic test Affiliating Genes
1 Alopecia20 22

Anatomical Context for Alopecia

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MalaCards organs/tissues related to Alopecia:

31
Skin, Thyroid, T cells, Prostate, Breast, Testes, Eye, Bone, Pituitary, Heart, Endothelial, Bone marrow, Ovary, Liver, Lung, Monocytes, Tongue, Thymus, Brain, Colon, Nk cells, B cells

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alopecia:
id TissueAnatomical CompartmentCell Relevance
1 HairHair FollicleFetal Hair Placode Cells Affected by disease
2 HairHair FollicleFetal Matrix Cells Affected by disease
3 DermisDermal PapillaGuard Dermal Papilla Cells Affected by disease
4 HairHair FolliclePrimary Hair Placode Cells Affected by disease

Animal Models for Alopecia or affiliated genes

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MGI Mouse Phenotypes related to Alopecia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.1HR, ALX4, IFNG, FOXN1, CLDN1
2MP:00020068.8HR, GZMB, IFNG, FOXN1, AIRE
3MP:00053918.8AIRE, FOXN1, IFNG, ALX4, HR

Publications for Alopecia

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Articles related to Alopecia:

(show top 50)    (show all 1731)
idTitleAuthorsYear
1
A study on the extracts of Cuscuta reflexa Roxb. in treatment of cyclophosphamide induced alopecia. (24393240)
2014
2
The Association of Lacrimal Gland Inflammation with Alopecia Areata. (25280049)
2014
3
Trichostasis spinulosa of the scalp mimicking Alopecia areata black dots. (25054768)
2014
4
Congenital triangular alopecia. (24403390)
2014
5
Is more hair always better? A single biopsy specimen is preferred for the evaluation of alopecia. (24117846)
2014
6
Scarring Alopecia in Classic Adult Type I Pityriasis Rubra Pilaris. (25015636)
2014
7
The Autoimmune Basis of Alopecia Areata: A Comprehensive Review. (25315746)
2014
8
Frontal fibrosing alopecia. (25128114)
2014
9
Genetic analysis of interleukin-1 receptor antagonist and interleukin-1I^ single-nucleotide polymorphisms C-511T and C+3953T in alopecia areata: susceptibility and severity association. (23584371)
2013
10
Female pattern alopecia: current perspectives. (24039457)
2013
11
Alopecia areata associated with Herpes zoster. (23682830)
2013
12
Therapy for alopecia areata in mice using parathyroid hormone agonists and antagonists, linked to a collagen-binding domain. (24326563)
2013
13
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. (24019775)
2013
14
Alopecia areata - Vitiligo overlap syndrome: an emerging clinical variant. (23760330)
2013
15
Summary of the Preceding Three Alopecia Areata Research Summits: What's Past Is Prologue. (24326556)
2013
16
Diffuse neurofibroma - an uncommon cause of alopecia. (24346909)
2013
17
Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship? (23329992)
2012
18
The follicular triad: a pathological clue to the diagnosis of early frontal fibrosing alopecia. (21787366)
2012
19
General practitioners' knowledge and practices related to alopecia areata in Qassim region, Saudi Arabia. (22415332)
2012
20
Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. (22763785)
2012
21
Temporary alopecia after embolization of an arteriovenous malformation. (23031381)
2012
22
Association between scalp psoriasis and alopecia areata. (22535354)
2012
23
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. (21272494)
2011
24
Investigative guidelines for alopecia areata. (21689240)
2011
25
Hair grooming practices and central centrifugal cicatricial alopecia. (19293007)
2009
26
Is Helicobacter pylori infection associated with alopecia areata? (19250167)
2009
27
Treatment of alopecia areata in children. (19685659)
2009
28
Compound heterozygous mutations in the vitamin D receptor in a patient with hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia. (19049339)
2009
29
Treatment of postmenopausal frontal fibrosing alopecia with oral dutasteride. (19539860)
2009
30
Alopecia areata is not associated with Helicobacter pylori. (20049262)
2009
31
Lack of efficacy of topical imiquimod in the treatment of patchy alopecia areata. (18986369)
2008
32
Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample. (18986440)
2008
33
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. (16914743)
2006
34
The alopecias associated with vitamin D-dependent rickets type IIA and with hairless gene mutations: a comparative clinical, histologic, and immunohistochemical study. (15781675)
2005
35
Androgenetic alopecia and current methods of treatment. (15818439)
2005
36
Association of a polymorphism in the ornithine decarboxylase gene with male androgenetic alopecia. (15761444)
2005
37
Vitamin D-dependent rickets Type II with alopecia: two case reports and review of the literature. (12956677)
2003
38
Androgenetic alopecia in men aged 40-69 years: prevalence and risk factors. (14674898)
2003
39
A mosaic pattern of alopecia in the oral-facial-digital syndrome type I (Papillon-LAcage and psaume syndrome). (10571835)
1999
40
Equine alopecia areata autoantibodies target multiple hair follicle antigens and may alter hair growth. A preliminary study. (9832317)
1998
41
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
42
Growth retardation, alopecia, pseudoanodontia, and optic atrophy (GAPO syndrome) with congenital glaucoma. (9230846)
1997
43
Alopecia universalis in liver transplant patients treated with cyclosporin. (7577610)
1995
44
Alopecia universalis as a single abnormality in an inbred Pakistani kindred. (8357006)
1993
45
Hormonal status in postmenopausal androgenetic alopecia. (1478763)
1992
46
Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice. (1536782)
1992
47
Alopecia in meralgia paresthetica. (3973115)
1985
48
Spontaneous cell-mediated cytotoxicity (SCMC) in patients with alopecia universalis. (6172934)
1981
49
Hyperkeratotic follicular plugging with alopecia totalis. (13774268)
1961
50
Alopecia totalis associated with onychodystrophy. (21065789)
1946

Variations for Alopecia

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Expression for genes affiliated with Alopecia

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Search GEO for disease gene expression data for Alopecia.

Pathways for genes affiliated with Alopecia

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Pathways related to Alopecia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GZMB, IFNG
2
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.7GZMB, IFNG
3
Show member pathways
9.7GZMB, IFNG

Compounds for genes affiliated with Alopecia

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Compounds related to Alopecia according to GeneCards Suite gene sharing:

(show all 17)
idCompoundScoreTop Affiliating Genes
1alpha-galactosylceramide4310.0GZMB, IFNG
217-hydroxypregnenolone4310.0SHBG, CYP21A2
311 deoxycortisol4310.0SHBG, CYP21A2
4leuprolide acetate439.9SHBG, CYP21A2
5clomiphene citrate439.9CYP21A2, SHBG
63-alpha-androstanediol glucuronide43 2410.9SHBG, CYP21A2
7concanamycin a43 5910.9IFNG, GZMB
817-hydroxyprogesterone43 2410.9CYP21A2, SHBG
9spironolactone43 59 28 49 1213.8SHBG, CYP21A2
10ivig439.7GZMB, IFNG
11ketoconazole43 28 24 1212.7CYP21A2, SHBG
12hydrocortisone43 2 59 1212.7CYP21A2, SHBG, IFNG
13dehydroepiandrosterone sulfate439.6CYP21A2, SHBG
14phenytoin43 49 28 1212.4SHBG, CYP21A2
15prednisolone43 28 1211.2GZMB, IFNG, SHBG, CYP21A2
16dexamethasone43 49 28 1212.0CYP21A2, SHBG, IFNG, GZMB
17arginine439.0CYP21A2, SHBG, IFNG, GZMB

GO Terms for genes affiliated with Alopecia

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Biological processes related to Alopecia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1humoral immune responseGO:00069599.9IFNG, AIRE
2hair follicle developmentGO:00019429.7ALX4, FOXN1

Products for genes affiliated with Alopecia

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Sources for Alopecia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet