MCID: ALP061
MIFTS: 44

Alopecia, Androgenetic, 1

Categories: Rare diseases

Aliases & Classifications for Alopecia, Androgenetic, 1

MalaCards integrated aliases for Alopecia, Androgenetic, 1:

Name: Alopecia, Androgenetic, 1 53 28 13 37 69
Androgenetic Alopecia 53 37 49 24 69
Androgenic Alopecia 49 24
Androgenetic Alopecia; Aga 53
Female Pattern Baldness 24
Female Pattern Alopecia 69
Male Pattern Alopecia 24
Male Pattern Baldness 24
Alopecia Androgenetic 51
Pattern Baldness 24
Aga1 53
Aga 53

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant in males
recessive in females


HPO:

31
alopecia, androgenetic, 1:
Inheritance sex-limited autosomal dominant


Classifications:



External Ids:

OMIM 53 109200
SNOMED-CT via HPO 65 278040002 56317004

Summaries for Alopecia, Androgenetic, 1

OMIM : 53 Androgenetic alopecia is characterized by a loss of hair from the scalp that follows a defined pattern (Hamilton, 1951). It occurs in women as well as in men. It is caused by a shortening of the anagen (growth) phase and miniaturization of the hair follicle, which results in the formation of progressively thinner, shorter hair (Bergfeld, 1995). In men, the condition is often referred to as male pattern baldness (MPB) and appears to be androgen-dependent (Hamilton, 1942). The condition is hereditary, and follows a pattern that may be consistent with an autosomal dominant trait (Osborn, 1916). Linkage evidence for an autosomal locus on 3q26 (AGA1) has been identified (Hillmer et al., 2008). See 300710 (AGA2) for a discussion of X linkage of androgenetic alopecia. A third locus has been found on chromosome 20p11 (AGA3; 612421). (109200)

MalaCards based summary : Alopecia, Androgenetic, 1, also known as androgenetic alopecia, is related to androgenic alopecia and prostatic hyperplasia, benign, and has symptoms including alopecia An important gene associated with Alopecia, Androgenetic, 1 is AGA3 (Alopecia, Androgenetic, 3), and among its related pathways/superpathways are Transcription Androgen Receptor nuclear signaling and Metabolism of steroid hormones. Related phenotype is endocrine/exocrine gland.

NIH Rare Diseases : 49 Androgenetic alopecia is a common form of hair loss in both men and women. In men, hair is usually lost in a well-defined pattern, beginning above both temples and is usually referred to as male-pattern baldness. Over time, the hairline recedes to form a characteristic 'M' shape. Hair also thins near the top of the head, often progressing to partial or complete baldness. The pattern of hair loss in women differs from men (female pattern hair loss). In women, the hair becomes thinner all over the head, and the hairline does not recede. Androgenetic alopecia in women rarely leads to total baldness. A variety of genetic and environmental factors likely play a role in causing this condition. Mutations in the AR gene have also been associated with androgenetic alopecia. Last updated: 8/19/2011

Genetics Home Reference : 24 Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness.

Related Diseases for Alopecia, Androgenetic, 1

Diseases in the Alopecia, Androgenetic, 2 family:

Alopecia, Androgenetic, 1 Alopecia, Androgenetic, 3

Diseases related to Alopecia, Androgenetic, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 androgenic alopecia 32.8 AR CYP19A1 SHBG
2 prostatic hyperplasia, benign 30.3 AR CYP19A1 SRD5A2
3 hermaphroditism 30.0 AR SHBG SRD5A2
4 hyperandrogenism 29.8 CYP19A1 CYP21A2 SHBG
5 prostate cancer 27.8 AR CFLAR CYP19A1 SHBG SRD5A1 SRD5A2
6 aspartylglucosaminuria 12.3
7 alopecia, androgenetic, 2 12.2
8 alopecia, androgenetic, 3 12.2
9 lysosomal storage disease 11.3
10 marie unna congenital hypotrichosis 11.2
11 alopecia 11.2
12 fabry disease 11.1
13 hypotrichosis 1 11.1
14 hypotrichosis simplex 11.1
15 fucosidosis 11.0
16 galactosemia 11.0
17 alopecia areata 10.5
18 prostatitis 10.4
19 mungan syndrome 10.4
20 telogen effluvium 10.3
21 47, xxy 10.3 AR SHBG
22 postmenopausal atrophic vaginitis 10.3 AR SHBG
23 aging 10.3
24 hypoactive sexual desire disorder 10.2 CYP19A1 SHBG
25 gender identity disorder 10.2 AR CYP19A1
26 lichen planopilaris 10.2
27 5-alpha reductase deficiency 10.1 SRD5A1 SRD5A2
28 estrogen excess 10.1 CYP19A1 SHBG
29 arteries, anomalies of 10.1
30 blood group, i system 10.1
31 coronary artery anomaly 10.1
32 heart disease 10.1
33 frontal fibrosing alopecia 10.1
34 androgen insensitivity syndrome 10.1 AR SHBG SRD5A2
35 prostatic hypertrophy 10.1 AR CYP19A1
36 complete androgen insensitivity syndrome 10.1 AR CYP19A1 SHBG
37 luteoma 10.0 CYP19A1 CYP21A2
38 gynecomastia 10.0 AR CYP19A1 SHBG
39 coronary heart disease 1 10.0
40 dermatitis 10.0
41 pustulosis of palm and sole 10.0
42 psoriasis 10.0
43 pseudohermaphroditism 10.0 AR CYP19A1 SRD5A2
44 reproductive system disease 10.0 AR CYP19A1 SHBG
45 prostatic adenoma 10.0 AR SHBG SRD5A1
46 penis agenesis 10.0 AR SRD5A1 SRD5A2
47 transsexualism 10.0 AR CYP19A1 CYP21A2
48 antley-bixler syndrome 9.9 CYP19A1 CYP21A2
49 neurofibromatosis, type ii 9.9
50 fibrosis of extraocular muscles, congenital, 1 9.9

Graphical network of the top 20 diseases related to Alopecia, Androgenetic, 1:



Diseases related to Alopecia, Androgenetic, 1

Symptoms & Phenotypes for Alopecia, Androgenetic, 1

Symptoms via clinical synopsis from OMIM:

53
Hair:
early baldness


Clinical features from OMIM:

109200

Human phenotypes related to Alopecia, Androgenetic, 1:

31
# Description HPO Frequency HPO Source Accession
1 alopecia 31 HP:0001596

MGI Mouse Phenotypes related to Alopecia, Androgenetic, 1:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.17 AR CFLAR CYP19A1 SRD5A1 SRD5A2 TGFB2

Drugs & Therapeutics for Alopecia, Androgenetic, 1

Search Clinical Trials , NIH Clinical Center for Alopecia, Androgenetic, 1

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alopecia, Androgenetic, 1 cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alopecia, Androgenetic, 1:
RepliCel Hair-01 (RCH-01), hair follicle-derived mesenchymal stem cells for treatment of androgenetic alopecia
Embryonic/Adult Cultured Cells Related to Alopecia, Androgenetic, 1:
Hair follicle mesenchymal stem cells (RepliCel Hair-01)

Genetic Tests for Alopecia, Androgenetic, 1

Genetic tests related to Alopecia, Androgenetic, 1:

# Genetic test Affiliating Genes
1 Alopecia, Androgenetic, 1 28

Anatomical Context for Alopecia, Androgenetic, 1

Publications for Alopecia, Androgenetic, 1

Articles related to Alopecia, Androgenetic, 1:

(show top 50) (show all 424)
# Title Authors Year
1
Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia. ( 29443105 )
2018
2
A Meta-analysis On Evidence Of Platelet-rich Plasma for Androgenetic Alopecia. ( 29440850 )
2018
3
Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia. ( 28932074 )
2017
4
A Pilot Study to Evaluate Effectiveness of Botulinum Toxin in Treatment of Androgenetic Alopecia in Males. ( 29403190 )
2017
5
Is there a pathogenetic link between frontal fibrosing alopecia, androgenetic alopecia and fibrosing alopecia in a pattern distribution? ( 29224248 )
2017
6
Psychosocial Impairment as a Possible Cause of Sexual Dysfunction among Young Men with Mild Androgenetic Alopecia: A Cross-sectional Crowdsourcing Web-based Study. ( 27149130 )
2016
7
A New Subtype of Lichen Planopilaris Affecting Vellus Hairs and Clinically Mimicking Androgenetic Alopecia. ( 27661430 )
2016
8
Meta-analysis of efficacy of platelet-rich plasma therapy for androgenetic alopecia. ( 27152474 )
2016
9
Commentary on A New Subtype of Lichen Planopilaris Affecting Vellus Hairs and Clinically Mimicking Androgenetic Alopecia. ( 27661431 )
2016
10
Relation of urinary stone disease with androgenetic alopecia and serum testosterone levels. ( 27155830 )
2016
11
A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia. ( 27631460 )
2016
12
Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia. ( 27151518 )
2016
13
Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males? ( 27192513 )
2016
14
Long-term efficacy and safety of the dual 5-alpha reductase blocker dutasteride on male androgenetic alopecia patients. ( 27988928 )
2016
15
The role of oxidative stress in early-onset androgenetic alopecia. ( 27987270 )
2016
16
Stem cell therapy as a novel therapeutic intervention for resistant cases of alopecia areata and androgenetic alopecia. ( 27553744 )
2016
17
Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia. ( 27060448 )
2016
18
Five-year efficacy of finasteride in 801 Japanese men with androgenetic alopecia. ( 25903108 )
2015
19
Characteristics of nonbalding scalp zones of androgenetic alopecia in East Asians. ( 25532463 )
2015
20
Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. ( 25842469 )
2015
21
Trichoscopic findings of androgenetic alopecia and their association with disease severity. ( 25810236 )
2015
22
The association of androgenetic alopecia and insulin resistance is independent of hyperandrogenemia: A case-control study. ( 25781062 )
2015
23
A Single-Centre, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men. ( 25765348 )
2015
24
Lichen Planopilaris in the Androgenetic Alopecia Area: A Pitfall for Hair Transplantation. ( 27171849 )
2015
25
Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. ( 25647436 )
2015
26
Safety concerns regarding 5I+ reductase inhibitors for the treatment of androgenetic alopecia. ( 25871957 )
2015
27
Lack of concordance and linkage disequilibrium among brothers for androgenetic alopecia and CAG/GGC haplotypes of the androgen receptor gene in Mexican families. ( 26178169 )
2015
28
Conditions simulating androgenetic alopecia. ( 25571781 )
2015
29
Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer. ( 24665929 )
2015
30
Erosive pustular dermatosis of the scalp following topical latanoprost for androgenetic alopecia. ( 25627907 )
2015
31
Association between androgenetic alopecia and coronary artery disease in young male patients. ( 25114445 )
2014
32
The efficacy and safety of 5I+-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit-risk assessment of finasteride and dutasteride. ( 23768246 )
2014
33
Immunohistochemical evaluation of androgen receptor and nerve structure density in human prepuce from patients with persistent sexual side effects after finasteride use for androgenetic alopecia. ( 24959691 )
2014
34
Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. ( 25254005 )
2014
35
Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia. ( 24351010 )
2014
36
Evidence for supplemental treatments in androgenetic alopecia. ( 25007363 )
2014
37
Severe androgenetic alopecia as a proxy of metabolic syndrome in male psoriatic patients older than 59 years. ( 24979347 )
2014
38
The effectiveness of finasteride and dutasteride used for 3 years in women with androgenetic alopecia. ( 25382509 )
2014
39
Inflammatory markers and Lp(a) levels as cardiovascular risk factors in androgenetic alopecia. ( 25536913 )
2014
40
Clinical utility and validity of minoxidil response testing in androgenetic alopecia. ( 25112173 )
2014
41
Impact of phototrichogram education on satisfaction of patients with androgenetic alopecia in clinical practice. ( 24986264 )
2014
42
Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men. ( 24981717 )
2014
43
Use of low-level laser therapy as monotherapy or concomitant therapy for male and female androgenetic alopecia. ( 25191036 )
2014
44
Hair diameter vs. hair density in male androgenetic alopecia. ( 25409994 )
2014
45
A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers. ( 25074865 )
2014
46
Acute telogen effluvium onset event is associated with the presence of female androgenetic alopecia: potential therapeutic implications. ( 24850277 )
2014
47
A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. ( 24411083 )
2014
48
Scalp dermatoscopic findings in androgenetic alopecia and their relations with disease severity. ( 25143677 )
2014
49
The use of low-level light therapy in the treatment of androgenetic alopecia and female pattern hair loss. ( 23924031 )
2014
50
Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. ( 25722600 )
2014

Variations for Alopecia, Androgenetic, 1

Expression for Alopecia, Androgenetic, 1

Search GEO for disease gene expression data for Alopecia, Androgenetic, 1.

Pathways for Alopecia, Androgenetic, 1

GO Terms for Alopecia, Androgenetic, 1

Cellular components related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.55 CYP19A1 CYP21A2 SRD5A1 SRD5A2 STS
2 organelle membrane GO:0031090 9.13 CYP21A2 SRD5A1 SRD5A2
3 cell body fiber GO:0070852 8.62 SRD5A1 SRD5A2

Biological processes related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.67 CYP21A2 SRD5A1 SRD5A2 STS
2 male gonad development GO:0008584 9.62 AR SRD5A1 SRD5A2 TGFB2
3 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.61 AR CFLAR
4 cellular response to estradiol stimulus GO:0071392 9.61 CFLAR SRD5A1
5 cellular response to dexamethasone stimulus GO:0071549 9.6 CFLAR SRD5A1
6 cell growth GO:0016049 9.59 AR TGFB2
7 sterol metabolic process GO:0016125 9.58 CYP19A1 CYP21A2
8 male genitalia development GO:0030539 9.58 SRD5A1 SRD5A2
9 response to testosterone GO:0033574 9.58 CFLAR SRD5A1 SRD5A2
10 uterus development GO:0060065 9.57 CYP19A1 TGFB2
11 hypothalamus development GO:0021854 9.56 SRD5A1 SRD5A2
12 androgen biosynthetic process GO:0006702 9.55 SRD5A1 SRD5A2
13 cellular response to testosterone stimulus GO:0071394 9.54 AR SRD5A1
14 progesterone metabolic process GO:0042448 9.52 SRD5A1 SRD5A2
15 prostate gland growth GO:0060736 9.51 AR CYP19A1
16 response to follicle-stimulating hormone GO:0032354 9.49 SRD5A1 SRD5A2
17 testosterone biosynthetic process GO:0061370 9.48 CYP19A1 SRD5A2
18 steroid catabolic process GO:0006706 9.46 SRD5A2 STS
19 positive regulation of integrin biosynthetic process GO:0045726 9.43 AR TGFB2
20 sex differentiation GO:0007548 9.43 AR SRD5A1 SRD5A2
21 androgen metabolic process GO:0008209 9.33 CYP19A1 SRD5A1 SRD5A2
22 steroid biosynthetic process GO:0006694 9.26 CYP19A1 CYP21A2 SRD5A1 SRD5A2
23 female genitalia development GO:0030540 8.8 CYP19A1 SRD5A1 SRD5A2

Molecular functions related to Alopecia, Androgenetic, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 CYP19A1 CYP21A2 SRD5A1 SRD5A2
2 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.4 SRD5A1 SRD5A2
3 steroid hydroxylase activity GO:0008395 9.37 CYP19A1 CYP21A2
4 androgen binding GO:0005497 9.32 AR SHBG
5 amide binding GO:0033218 9.26 SRD5A1 SRD5A2
6 cholestenone 5-alpha-reductase activity GO:0047751 9.16 SRD5A1 SRD5A2
7 3-oxo-5-alpha-steroid 4-dehydrogenase activity GO:0003865 8.96 SRD5A1 SRD5A2
8 steroid binding GO:0005496 8.8 AR CYP21A2 SHBG

Sources for Alopecia, Androgenetic, 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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