AA
MCID: ALP009
MIFTS: 61

Alopecia Areata (AA) malady

Skin diseases category

Summaries for Alopecia Areata

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Alopecia areata is an autoimmune disease in which the immune system mistakenly attacks the hair follicles. this can lead to hair loss on the scalp and elsewhere on the body. in most cases, hair falls out in small, round patches on the scalp. although uncommon, hair loss can be more extensive in some people. this condition can progress to cause total loss of hair on the head (alopecia totalis) or complete loss of hair on the head, face, and body (alopecia universalis). while there is neither a cure for nor drugs approved for treatment, some people find that medications approved for other purposes can help their hair grow back. last updated: 5/9/2011

MalaCards: Alopecia Areata, also known as circumscribed alopecia, is related to alopecia and vitiligo. An important gene associated with Alopecia Areata is AIRE (autoimmune regulator), and among its related pathways are Rheumatoid arthritis and Malaria. The compounds pge2 and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 An autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body initally causing bald spots.

Wikipedia:63 Alopecia areata (AA) is a condition in which hair is lost from some or all areas of the body, usually... more...

Description from OMIM:46 104000,610753

Aliases & Classifications for Alopecia Areata

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8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 46OMIM, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

alopecia areata 8 42 20 22 10 44 60
circumscribed alopecia 8
alopecia circumscripta 42
alopecia cicatrisata 42
cazenave's vitiligo 42
alopecia totalis 60
alopecia celsi 42
aa 42


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Disease Ontology8 DOID:986
ICD9CM27 704.01
ICD1025 L63

Related Diseases for Alopecia Areata

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17GeneCards, 18GeneDecks
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Diseases in the Alopecia Areata family:

Alopecia Areata 2 Alopecia Areata 1

Diseases related to Alopecia Areata via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia32.2AIRE
2vitiligo31.0AIRE, CIITA
3psoriasis31.0IL1A, ICAM1, GZMB, IFNG, CCL27, IL1R1
4dermatitis30.9IFNG, CCL27, ICAM1, IL1A, GZMB
5thyroiditis30.7CIITA
6lichen planus30.7ICAM1, GZMB
7atopic dermatitis30.6FCGR1A, ICAM1, IFNG, CCL27, IL1A
8myasthenia gravis30.5IFNG, AIRE
9diabetes mellitus30.5ICAM1, IL1R1, AIRE
10skin disease30.5CCL27, TCHH, IL1A, CIITA, ICAM1, IFNG
11autoimmune thyroiditis30.3IFNG, ICAM1, CIITA, AIRE
12arthritis30.3ICAM1, IL1A, IL1R1, IL1RN, CIITA, TNFSF13
13thymoma30.3IL1A, AIRE, IL1R1
14rheumatoid arthritis30.3IL1A, GZMB, KLRK1, CCL27, IFNG, FCGR1A
15down syndrome30.3AIRE
16prostate cancer30.1GZMB, FCGR1A, IL1R1
17kawasaki disease30.1CIITA
18thrombocytopenia30.1IL1A, IL1R1
19celiac disease30.1KLRK1, GZMB, CIITA
20hepatitis b30.1GZMB, CIITA, IFNG, CCL27
21hepatitis30.1AIRE, GZMB, CCL27
22keratoconjunctivitis30.1AIRE
23graves' disease30.1IFNG, CIITA, IL1A, IL1RN, ICAM1, AIRE
24ulcerative colitis30.1IL1R1, ICAM1, GZMB, IFNG, IL1A, IL1RN
25uveitis30.1IFNG, ICAM1, IL1R1, IL1A
26acute leukemia30.1FCGR1A
27mycosis fungoides30.1GZMB, CCL27
28systemic lupus erythematosus30.1ICAM1, KLRK1, IFNG, CIITA, TNFSF13, FCGR1A
29leukemia30.1IL1R1, ICAM1, IL1A, IFNG, GZMB, KLRK1
30lymphopenia30.1IL1RN, IFNG, CIITA
31allergic contact dermatitis30.1ICAM1, CCL27
32hepatitis c30.1IL1R1, CIITA, IFNG
33myositis30.0IL1A, GZMB, ICAM1, CIITA, IL1RN
34breast cancer30.0GZMB, CIITA, IL1R1, FCGR1A
35obesity30.0MC2R
36inflammatory bowel disease29.9ICAM1, IL1RN
37influenza29.9GZMB, CIITA, IFNG
38asthma29.9ICAM1, CIITA, IFNG, GZMB
39pneumonia29.9ICAM1
40ovarian cancer29.9IL1A
41sarcoma29.9IL1R1
42polymyalgia rheumatica29.7IL1RN
43malaria29.7ICAM1, IFNG
44schnitzler syndrome29.7IL1RN, IL1R1
45periodontal disease29.7ICAM1
46chorioamnionitis29.7IL1RN, IL1R1
47myeloma29.7ICAM1, KLRK1, CIITA, FCGR1A
48tuberculosis29.7IFNG, CIITA, GZMB, KLRK1
49wegener's granulomatosis29.7CIITA
50relapsing-remitting multiple sclerosis29.7ICAM1, IFNG, IL1RN

Graphical network of the top 20 diseases related to Alopecia Areata:



Diseases related to alopecia areata

Clinical Features for Alopecia Areata

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46OMIM
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Clinical features from OMIM:

104000,610753

Drugs & Therapeutics for Alopecia Areata

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alopecia Areata

Drug clinical trials:

Search ClinicalTrials for Alopecia Areata

Search NIH Clinical Center for Alopecia Areata

Search CenterWatch for Alopecia Areata

Genetic Tests for Alopecia Areata

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20GeneTests, 22GTR
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Genetic tests related to Alopecia Areata:

id Genetic test Affiliating Genes
1 Alopecia Areata20 22

Anatomical Context for Alopecia Areata

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32MalaCards
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MalaCards organs/tissues related to Alopecia Areata:

32
Skin, T cells, Thyroid, Testes, Endothelial, Pituitary, Monocytes, Nk cells, Heart, Thymus, Bone

Animal Models for Alopecia Areata or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alopecia Areata:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4CIITA, TNFSF13, ICAM1, FCGR1A, IL1A, GZMB
2MP:000537610.4IFNG, GZMB, ICAM1, CIITA, AIRE, MC2R
3MP:000200610.3KLRK1, IL1R1, AIRE, ICAM1, IFNG
4MP:000538710.3GZMB, IFNG, KLRK1, ICAM1, TNFSF13, CIITA
5MP:000538410.1ICAM1, CIITA, AIRE, TNFSF13, IL1RN, IL1R1

Publications for Alopecia Areata

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50PubMed
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Articles related to Alopecia Areata:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Alopecia areata associated with Herpes zoster. (23682830)
2013
2
Therapy for alopecia areata in mice using parathyroid hormone agonists and antagonists, linked to a collagen-binding domain. (24326563)
2013
3
Alopecia areata during treatment with adalimumab: therapy with an alternative TNF-alpha inhibitor is possible. (23279686)
2013
4
Practice gaps. Alopecia areata and comorbid conditions. (23699633)
2013
5
Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata. (24151515)
2013
6
Genes and immune response in alopecia areata: review of the alopecia areata research summit first day proceedings. (24326540)
2013
7
Severe onycholysis in a card illusionist with alopecia areata universalis. (24403770)
2013
8
Koebner phenomenon in alopecia areata: rapid appearance after trichogram. Implications for the pathogenesis and therapy. (23588149)
2013
9
Psychiatric symptomatology and health-related quality of life in children and adolescents with alopecia areata. (24237476)
2013
10
Granulomatous alopecia: a variant of alopecia areata? (23506008)
2013
11
Association of HSPA1B SNP rs6457452 with Alopecia Areata in the Korean Population. (24303776)
2013
12
T-helper and regulatory T-cell cytokines in the peripheral blood of patients with active alopecia areata. (23607748)
2013
13
Advances in the management of alopecia areata. (22211297)
2012
14
Alopecia areata as a model for T cell-dependent autoimmune diseases. (22621196)
2012
15
Case of intractable ophiasis type of alopecia areata presumably improved by fexofenadine. (22594793)
2012
16
The appearance of pili annulati following alopecia areata. (22530334)
2012
17
Concomitant presentation of alopecia areata in siblings: a rare occurrence. (23180915)
2012
18
Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. (21936853)
2012
19
A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata. (22855038)
2012
20
Randomized comparison of topical betamethasone valerate foam, intralesional triamcinolone acetonide and tacrolimus ointment in management of localized alopecia areata. (21769231)
2011
21
Efficacy and tolerability of methotrexate in severe childhood alopecia areata. (21517797)
2011
22
'Follicular Swiss cheese' pattern--another histopathologic clue to alopecia areata. (21062342)
2011
23
Alopecia areata. (21453266)
2011
24
Prognostic factors in methylprednisolone pulse therapy for alopecia areata. (21592197)
2011
25
Bimatoprost in the treatment of eyelash universalis alopecia areata. (21712909)
2010
26
Cutis verticis gyrata and alopecia areata: a synchronous coincidence? (20499434)
2010
27
Complementary and alternative medicine in alopecia areata. (20000871)
2010
28
Cytokines and other mediators in alopecia areata. (20300578)
2010
29
Treatment effects of intradermal botulinum toxin type A injection on alopecia areata. (21134049)
2010
30
Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata. (20388588)
2010
31
Intralesional steroids for alopecia areata. (21188031)
2010
32
Quality of life in alopecia areata: a study of 60 cases. (20720568)
2010
33
Concordance rate of alopecia areata in identical twins supports both genetic and environmental factors. (20159328)
2010
34
Management of autoimmune associated alopecia areata. (20527485)
2010
35
Hair follicles from alopecia areata patients exhibit alterations in immune privilege-associated gene expression in advance of hair loss. (20613773)
2010
36
Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopy. (19874320)
2010
37
Nail changes in alopecia areata: frequency and clinical presentation. (18540984)
2009
38
Prolactin levels in the patients with alopecia areata. (19453813)
2009
39
Alefacept for severe alopecia areata: a randomized, double-blind, placebo-controlled study. (19917955)
2009
40
Attitudes of dermatologists in the southeastern United States regarding treatment of alopecia areata: a cross-sectional survey study. (19909522)
2009
41
Diabetic ketoacidosis, thyroiditis and alopecia areata in a child with Down syndrome. (20012788)
2009
42
Efficacy of combination therapy for the management regime of Alopecia areata. (17917625)
2007
43
Association between alopecia areata and HLA Class I and II in Turkey. (16361713)
2005
44
Clinical evolution of alopecia areata with a male androgenetic alopecia pattern to sisaipho. (10694313)
2000
45
Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. (9421466)
1998
46
Cytokines and growth factors influence hair growth in vitro. Possible implications for the pathogenesis and treatment of alopecia areata. (8967784)
1996
47
Follicular mucinosis in alopecia areata. (1471749)
1992
48
Trichotillomania associated with alopecia areata. (6825461)
1983
49
Twenty-nail dystrophy of alopecia areata. (7377792)
1980
50
The emotional disturbance underlying alopecia areata, alopecia totalis and trichotillomania. (527390)
1979

Genetic Variations for Alopecia Areata

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Expression for genes affiliated with Alopecia Areata

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alopecia Areata

Search GEO for disease gene expression data for Alopecia Areata.

Pathways for genes affiliated with Alopecia Areata

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 53Reactome
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Pathways related to Alopecia Areata according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5TNFSF13
210.5KLRK1
3
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10.5IL1R1, GZMB, IFNG
4
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10.5GZMB, IFNG, IL1R1
510.4IFNG, ICAM1, CIITA
6
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10.4IL1A, IFNG, IL1R1
7
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10.4IL1RN, IL1R1, IL1A
8
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10.4IL1RN, IL1R1, IL1A
910.4IL1R1, IL1A, FCGR1A
10
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10.4ICAM1, CIITA, IFNG, IL1A
11
Immune response Bacterial infections in normal airways
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10.4IL1RN, IL1R1, IL1A, IFNG
1210.4TNFSF13, IL1R1, IL1A, ICAM1
1310.4FCGR1A, IL1A, IFNG, IL1R1
14
Hide members
10.4IL1A, IFNG, FCGR1A, CIITA
1510.4IFNG, CIITA, FCGR1A, IL1A
16
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10.4ULBP3, ICAM1, KLRK1
17
Hide members
10.4IL1A, IFNG, CIITA, GZMB, TNFSF13, ICAM1
18
Hide members
10.4ULBP3, IFNG, GZMB, ICAM1, KLRK1
19
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10.4FCGR1A, IFNG, TNFSF13, FCGR1B, GZMB
20
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10.4IL1RN, CIITA, IL1R1, IL1A, ULBP3, ICAM1
21
Hide members
10.4FCGR1A, FCGR1B, IL1A, IL1R1, IL1RN, ICAM1

Compounds for genes affiliated with Alopecia Areata

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Alopecia Areata according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge24410.9CCL27
2pentoxifylline44 1111.9IL1R1, IL1RN
3endotoxin4410.9ICAM1, CIITA
4rantes4410.9IFNG, IL1A, IL1R1, CIITA, ICAM1, GZMB
5gold sodium thiomalate4410.9IL1R1, IL1RN, IFNG, IL1A
6neopterin4410.9IL1A, IL1R1, IL1RN, ICAM1, GZMB, IFNG
7prednisolone44 28 1112.9IL1R1, FCGR1A, GZMB
8ivig4410.9IFNG, GZMB, IL1RN, IL1R1, IL1A, FCGR1A
9hydrocortisone44 2 59 1113.9MC2R
10cycloheximide4410.9FCGR1A
11adalimumab44 49 1112.9IL1RN, IL1R1, FCGR1A, IFNG
12sulfasalazine44 28 49 1113.9ICAM1, IL1A, IL1RN, IL1R1
13polymyxin b4410.9IL1A, IL1RN, ICAM1, IFNG
14ccl344 2811.8ICAM1, IFNG, CCL27, IL1R1, IL1A
15polyinosinic-polycytidylic acid4410.8IL1A, CIITA, IFNG, KLRK1
16cyclosporin a44 28 5912.8IL1RN, IL1R1, CIITA, IL1A, ICAM1, GZMB
17etanercept44 49 1112.8IL1RN, IL1R1, IFNG, FCGR1A
18sb 20358044 5911.8AIRE, IL1RN, ICAM1, IFNG, IL1R1, IL1A
19dexamethasone44 49 28 1113.8FCGR1A, CCL27, GZMB, CIITA, MC2R, IL1R1
20ribonucleic acid4410.8GZMB, CIITA, MC2R, IL1R1, IL1A, FCGR1A
21pirfenidone44 5911.8IL1A
22il 104410.8IL1RN, IL1A, IFNG, IL1R1
23simvastatin44 49 59 28 11 2415.8CIITA, IL1RN, IFNG, ICAM1, IL1A
24hyaluronic acid44 2411.8GZMB, ICAM1, IL1A, IL1RN, IL1R1
25natalizumab44 1111.8ICAM1, IFNG, FCGR1A
26tarc4410.8IFNG, ICAM1, IL1A, CCL27
27amphotericin b4410.8IL1R1, IFNG, IL1RN
28allergens4410.8CIITA, IL1RN, IFNG, CCL27
29actinomycin d4410.8IL1R1, CIITA, IL1A, IFNG, FCGR1A, ICAM1
30polyethylene glycol4410.8IL1RN, IL1R1, ICAM1, IL1A
31minocycline44 1111.8CIITA, IL1A, ICAM1
322-chloroethyl ethyl sulfide4410.8IL1RN, IL1A
33sodium dodecylsulfate4410.7IL1RN, CIITA, IL1R1, IL1A
34nitric oxide44 11 2412.7CIITA, ICAM1, GZMB, IFNG, IL1A, IL1R1
35cuprophan4410.7ICAM1, IL1RN, IL1R1
36gm-csf44 2811.7IFNG, ICAM1
37oxygen44 2411.7FCGR1A, CIITA, KLRK1, ICAM1
38retinoic acid44 2411.7IL1R1, IL1A, IFNG, ICAM1, IL1RN, KLRK1
39herbimycin a44 5911.6IFNG, FCGR1A, IL1A, ICAM1
40calcium44 49 11 2413.6KLRK1, GZMB, ULBP3, CCL27, CIITA, MC2R
41fmlp4410.6IL1RN, FCGR1A, IL1A, ICAM1
42cholesterol44 28 11 2413.6MC2R, IL1R1, FCGR1A, IL1RN, CIITA, CCL27
43vegf4410.6IL1A, IL1R1, IL1RN, GZMB, IFNG, ICAM1
44infliximab44 49 1112.6IL1R1, IL1RN, IFNG
45arginine4410.5KLRK1, TCHH, IL1A, IL1R1, GZMB, IFNG
46cellulose triacetate4410.5IL1A, IL1RN
47peptidoglycan44 2811.4IL1RN, CIITA, IL1R1
48pdtc4410.4IFNG, ICAM1, IL1A
49alanine4410.3MC2R, IL1RN, IL1R1, CCL27, CIITA, GZMB
50interferon gamma4410.2IFNG, ICAM1

GO Terms for genes affiliated with Alopecia Areata

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16Gene Ontology
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Cellular components related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4IL1A, IL1RN, IL36RN, TNFSF13, ICAM1, IFNG

Biological processes related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:06033310.5FCGR1A, FCGR1B, CIITA, IFNG, ICAM1
2immune responseGO:00695510.5AIRE, TNFSF13, CIITA, IL1RN, IL1R1, IL1A
3response to copper ionGO:04668810.5ICAM1, IL1A
4cytokine-mediated signaling pathwayGO:01922110.4IFNG, ICAM1, CIITA, FCGR1B, FCGR1A, IL1A
5positive regulation of MHC class II biosynthetic processGO:04534810.4IFNG, CIITA
6negative regulation of cytokine-mediated signaling pathwayGO:00196010.1IL36RN, IL1RN

Molecular functions related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.4IL1RN, IL36RN, IL1A
2IgG bindingGO:01986410.4FCGR1B, FCGR1A
3interleukin-1 receptor antagonist activityGO:00515210.3IL36RN, IL1RN
4cytokine activityGO:00512510.1IL1A, IFNG, TNFSF13, IL36RN

Products for genes affiliated with Alopecia Areata

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  • Antibodies
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Sources for Alopecia Areata

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet