AA
MCID: ALP009
MIFTS: 59

Alopecia Areata (AA) malady

Skin category

Summaries for Alopecia Areata

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Alopecia areata is an autoimmune disease in which the immune system mistakenly attacks the hair follicles. this can lead to hair loss on the scalp and elsewhere on the body. in most cases, hair falls out in small, round patches on the scalp. although uncommon, hair loss can be more extensive in some people. this condition can progress to cause total loss of hair on the head (alopecia totalis) or complete loss of hair on the head, face, and body (alopecia universalis). while there is neither a cure for nor drugs approved for treatment, some people find that medications approved for other purposes can help their hair grow back. last updated: 5/9/2011

MalaCards: Alopecia Areata, also known as circumscribed alopecia, is related to alopecia and vitiligo. An important gene associated with Alopecia Areata is AIRE (autoimmune regulator), and among its related pathways are Rheumatoid arthritis and Malaria. The compounds pge2 and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include skin, thymus and heart, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 An autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body initally causing bald spots.

Wikipedia:64 Alopecia areata (AA) is a condition in which hair is lost from some or all areas of the body, usually... more...

Description from OMIM:47 104000,610753

Aliases & Classifications for Alopecia Areata

Sources:
8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 47OMIM, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

alopecia areata 8 43 20 22 10 45 61
circumscribed alopecia 8
alopecia circumscripta 43
alopecia cicatrisata 43
cazenave's vitiligo 43
alopecia totalis 61
alopecia celsi 43
aa 43


External Ids:

Disease Ontology8 DOID:986
ICD9CM27 704.01
ICD1025 L63

Related Diseases for Alopecia Areata

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Alopecia Areata family:

alopecia areata 2 alopecia areata 1

Diseases related to Alopecia Areata via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 307)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia32.2AIRE
2vitiligo31.0CIITA, AIRE
3lichen planus30.7GZMB, ICAM1
4atopy30.7IFNG
5atopic dermatitis30.7CCL27, IFNG, ICAM1, IL1A, FCGR1A
6thyroiditis30.4CIITA
7arthritis30.4IFNG, GZMB, ICAM1, TNFSF13, CIITA, IL1RN
8thymoma30.4IL1A, IL1R1, AIRE
9oral lichen planus30.4IL1A, ICAM1
10kawasaki disease30.1CIITA
11thrombocytopenia30.1IL1R1, IL1A
12celiac disease30.1KLRK1, GZMB, CIITA
13graves' disease30.1IL1A, IL1RN, AIRE, CIITA, ICAM1, IFNG
14ulcerative colitis30.1IFNG, GZMB, ICAM1, IL1RN, IL1R1, IL1A
15uveitis30.1IL1A, IL1R1, ICAM1, IFNG
16acute leukemia30.1FCGR1A
17mycosis fungoides30.1CCL27, GZMB
18systemic lupus erythematosus30.1KLRK1, IFNG, ICAM1, TNFSF13, CIITA, IL1RN
19allergic contact dermatitis30.1ICAM1, CCL27
20asthma29.9IFNG, GZMB, ICAM1, CIITA
21septic shock29.9CIITA, IL1RN, IL1R1, IL1A, FCGR1A
22sepsis29.9FCGR1A, IL1A, IL1R1, IL1RN, CIITA
23polymyalgia rheumatica29.7IL1RN
24nephritis29.7IL1R1, IL1RN
25schnitzler syndrome29.7IL1RN, IL1R1
26chorioamnionitis29.7IL1RN, IL1R1
27tuberculosis29.7CIITA, GZMB, IFNG, KLRK1
28wegener's granulomatosis29.7CIITA
29relapsing-remitting multiple sclerosis29.7IFNG, ICAM1, IL1RN
30colorectal cancer29.7GZMB, KLRK1
31adenoma29.7MC2R
32acute pancreatitis29.7IL1R1, IL1RN
33amyloidosis10.9
34alopecia universalis10.9
35diffuse alopecia areata10.7
36alopecia totalis10.6
37trichotillomania10.5
38alopecia areata 210.5
39alopecia areata 110.5
40pili annulati10.5
41amyloidosis, renal10.5
42amyloidosis, secondary10.4
43telogen effluvium10.4
44al amyloidosis10.3
45relapsing polychondritis10.3
46chronic mucocutaneous candidiasis10.3
47twenty-nail dystrophy10.3
48amyloidosis aa10.3
49neurodermatitis10.3
50folliculitis10.3

Graphical network of the top 20 diseases related to Alopecia Areata:



Diseases related to alopecia areata

Clinical Features for Alopecia Areata

Sources:
47OMIM
See all sources

Clinical features from OMIM:

104000,610753

Drugs & Therapeutics for Alopecia Areata

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alopecia Areata

Drug clinical trials:

Search ClinicalTrials for Alopecia Areata

Search NIH Clinical Center for Alopecia Areata

Search CenterWatch for Alopecia Areata

Genetic Tests for Alopecia Areata

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Alopecia Areata:

id Genetic test Affiliating Genes
1 Alopecia Areata20 22

Anatomical Context for Alopecia Areata

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Alopecia Areata:

33
Skin, Thymus, Heart, Thyroid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Pituitary

Animal Models for Alopecia Areata or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Alopecia Areata

Sources:
51PubMed
See all sources

Articles related to Alopecia Areata:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Pulse methylprednisolone therapy for the treatment of extensive alopecia areata. (23336179)
2014
2
Sleep quality in patients with alopecia areata: questionnaire-based study. (23451837)
2014
3
Growth hormone deficiency in a young patient with alopecia areata. (24326559)
2013
4
Concomitant alopecia areata and hypertrichosis after infliximab therapy: rara avis. (24131912)
2013
5
No basophil infiltration in alopecia areata irrespective of the intensity of eosinophil infiltration. (22948616)
2013
6
Resident Rounds. Part III B: tumor necrosis factor-I+ antagonists and alopecia areata: a class-wide adverse effect. (23839195)
2013
7
The role of hair follicle immune privilege collapse in alopecia areata: status and perspectives. (24326544)
2013
8
Annular alopecia areata: report of two cases. (24403774)
2013
9
Anti-inflammatory effect of electroacupuncture in the C3H/HeJ mouse model of alopecia areata. (23103957)
2013
10
Alopecia areata treated with phenolisation and intravenous dexamethasone pulses. (23960401)
2013
11
A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata. (23607773)
2013
12
Genetic evidence for the involvement of NOTCH4 in rheumatoid arthritis and alopecia areata. (23318300)
2013
13
Toward T cell protein-protein interaction activity relevant to alopecia areata. (24326546)
2013
14
Association analysis of the HLA-C gene in Japanese alopecia areata. (23588886)
2013
15
Inhibitory effect of tianeptine on catagen induction in alopecia areata-like lesions induced by ultrasonic wave stress in mice. (23581888)
2013
16
A functional polymorphism in interleukin-1I+ (IL1A) gene is associated with risk of alopecia areata in Chinese populations. (23542780)
2013
17
Equine alopecia areata: a retrospective clinical descriptive study at the University of California, Davis (1980-2011). (23432467)
2013
18
Histopathologic features of alopecia areata incognito: a review of 46 cases. (22616601)
2012
19
Alopecia areata of dental origin in a child. (23422615)
2012
20
Eyelash alopecia areata: case series and literature review. (22883840)
2012
21
Psychological status of patients with alopecia areata. (22678566)
2012
22
Investigation of selected cytokine genes suggests that IL2RA and the TNF/LTA locus are risk factors for severe alopecia areata. (22897480)
2012
23
A comment regarding 'follicular Swiss cheese' in the diagnosis of alopecia areata. (22264251)
2012
24
A case-control study on family dysfunction in patients with alopecia areata, psoriasis and atopic dermatitis. (21336474)
2011
25
Alopecia areata: Support groups and meetings - how can it help your patient? (21689238)
2011
26
Renbok phenomenon between psoriasis and alopecia areata. (21623882)
2011
27
Relapsing polychondritis associated with psoriasis vulgaris and alopecia areata. (21697067)
2011
28
Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata. (21981340)
2011
29
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (20596022)
2010
30
Dermatoglyphic patterns in psoriasis, vitiligo and alopecia areata. (20228553)
2010
31
Melanocortin receptor type 2 (MC2R, ACTH receptor) expression in patients with alopecia areata. (20590821)
2010
32
Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. (20115945)
2010
33
Woolly hair with alopecia areata in a Caucasian girl. (20153996)
2010
34
Development of alopecia areata is associated with higher central and peripheral hypothalamic-pituitary-adrenal tone in the skin graft induced C3H/HeJ mouse model. (19020552)
2009
35
Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis. (18614380)
2009
36
Medium-dose prednisolone pulse therapy in alopecia areata. (21572877)
2009
37
Lack of efficacy of topical imiquimod in the treatment of patchy alopecia areata. (18986369)
2008
38
An uncontrolled, open label study of sulfasalazine in severe alopecia areata. (19171984)
2008
39
Alopecia areata in Turkey: demographic and clinical features. (18384559)
2008
40
Alopecia areata: topical immunotherapy treatment with diphencyprone. (18005118)
2008
41
Vitamin D receptor gene polymorphisms are not associated with alopecia areata. (17822494)
2007
42
Interleukin-16 in patients with alopecia areata. (15619436)
2005
43
Lack of association between Vitamin D receptor FokI polymorphism and alopecia areata. (15246940)
2004
44
Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study. (15149507)
2004
45
Idiopathic CD4+ T lymphocytopenia associated with disseminated flat warts and alopecia areata. (12432998)
2002
46
Treatments for androgenetic alopecia and alopecia areata: current options and future prospects. (11217871)
2001
47
Structure and polymorphism of the human gene for the interferon- induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. (10942113)
2000
48
Equine alopecia areata autoantibodies target multiple hair follicle antigens and may alter hair growth. A preliminary study. (9832317)
1998
49
Thymopentin in alopecia areata]. (9576023)
1998
50
ALOPECIA AREATA AND ALOPECIA TOTALIS. EFFECT OF LOCAL COMBINED PSORALENS AND TRIAMCINOLONE UNDER ULTRA VIOLET IRRADIATIONS. (14162116)
1963

Genetic Variations for Alopecia Areata

Expression for genes affiliated with Alopecia Areata

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alopecia Areata

Search GEO for disease gene expression data for Alopecia Areata.

Pathways for genes affiliated with Alopecia Areata

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN, 54Reactome
See all sources

Pathways related to Alopecia Areata according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5TNFSF13
210.5KLRK1
3
Hide members
10.5IL1R1, GZMB, IFNG
4
Hide members
10.5IFNG, GZMB, IL1R1
510.4IFNG, ICAM1, CIITA
6
Hide members
10.4IL1A, IL1R1, IFNG
7
Hide members
10.4IL1A, IL1R1, IL1RN
8
Hide members
10.4IL1A, IL1R1, IL1RN
910.4IL1R1, IL1A, FCGR1A
10
Hide members
10.4IFNG, ICAM1, CIITA, IL1A
11
Immune response Bacterial infections in normal airways
Hide members
10.4IFNG, IL1RN, IL1R1, IL1A
1210.4IL1A, IL1R1, TNFSF13, ICAM1
1310.4FCGR1A, IL1A, IL1R1, IFNG
14
Hide members
10.4IFNG, CIITA, IL1A, FCGR1A
1510.4IFNG, CIITA, IL1A, FCGR1A
16
Hide members
10.4ICAM1, ULBP3, KLRK1
17
Hide members
10.4IFNG, GZMB, ICAM1, TNFSF13, CIITA, IL1A
18
Hide members
10.4KLRK1, ULBP3, IFNG, GZMB, ICAM1
19
Hide members
10.4FCGR1B, FCGR1A, TNFSF13, GZMB, IFNG
20
Hide members
10.4KLRK1, ULBP3, IFNG, ICAM1, CIITA, IL1RN
21
Hide members
10.4FCGR1B, IFNG, ICAM1, CIITA, IL1RN, IL1R1

Compounds for genes affiliated with Alopecia Areata

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Alopecia Areata according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge24510.9CCL27
2pentoxifylline45 1111.9IL1RN, IL1R1
3endotoxin4510.9CIITA, ICAM1
4rantes4510.9IL1A, IL1R1, CIITA, ICAM1, GZMB, IFNG
5gold sodium thiomalate4510.9IFNG, IL1RN, IL1R1, IL1A
6neopterin4510.9IFNG, GZMB, ICAM1, IL1RN, IL1R1, IL1A
7prednisolone45 29 1112.9GZMB, IL1R1, FCGR1A
8ivig4510.9IFNG, GZMB, IL1RN, IL1R1, IL1A, FCGR1A
9hydrocortisone45 2 60 1113.9MC2R
10cycloheximide4510.9FCGR1A
11adalimumab45 50 1112.9IFNG, IL1RN, IL1R1, FCGR1A
12sulfasalazine45 29 50 1113.9IL1A, IL1R1, IL1RN, ICAM1
13polymyxin b4510.9IFNG, ICAM1, IL1RN, IL1A
14ccl345 2911.8CCL27, IFNG, ICAM1, IL1R1, IL1A
15polyinosinic-polycytidylic acid4510.8IL1A, CIITA, IFNG, KLRK1
16cyclosporin a45 29 6012.8IFNG, GZMB, ICAM1, CIITA, IL1RN, IL1R1
17etanercept45 50 1112.8IFNG, IL1RN, IL1R1, FCGR1A
18sb 20358045 6011.8IL1A, IL1R1, IL1RN, AIRE, ICAM1, IFNG
19dexamethasone45 50 29 1113.8CCL27, GZMB, CIITA, MC2R, IL1R1, FCGR1A
20ribonucleic acid4510.8GZMB, CIITA, MC2R, IL1RN, IL1R1, IL1A
21pirfenidone45 6011.8IL1A
22il 104510.8IL1A, IL1R1, IL1RN, IFNG
23simvastatin45 50 60 29 11 2415.8IFNG, ICAM1, CIITA, IL1RN, IL1A
24hyaluronic acid45 2411.8GZMB, ICAM1, IL1RN, IL1R1, IL1A
25natalizumab45 1111.8FCGR1A, ICAM1, IFNG
26tarc4510.8IL1A, ICAM1, IFNG, CCL27
27amphotericin b4510.8IFNG, IL1RN, IL1R1
28allergens4510.8CCL27, IFNG, CIITA, IL1RN
29actinomycin d4510.8IFNG, ICAM1, CIITA, IL1R1, IL1A, FCGR1A
30polyethylene glycol4510.8IL1A, IL1R1, IL1RN, ICAM1
31minocycline45 1111.8ICAM1, CIITA, IL1A
322-chloroethyl ethyl sulfide4510.8IL1A, IL1RN
33sodium dodecylsulfate4510.7CIITA, IL1RN, IL1R1, IL1A
34nitric oxide45 11 2412.7IFNG, GZMB, ICAM1, CIITA, IL1RN, IL1R1
35cuprophan4510.7IL1R1, IL1RN, ICAM1
36gm-csf45 2911.7ICAM1, IFNG
37oxygen45 2411.7KLRK1, ICAM1, CIITA, FCGR1A
38retinoic acid45 2411.7KLRK1, IFNG, GZMB, ICAM1, IL1RN, IL1R1
39herbimycin a45 6011.6IFNG, ICAM1, IL1A, FCGR1A
40calcium45 50 11 2413.6KLRK1, ULBP3, CCL27, GZMB, CIITA, MC2R
41fmlp4510.6FCGR1A, IL1A, IL1RN, ICAM1
42cholesterol45 29 11 2413.6CCL27, CIITA, MC2R, IL1RN, IL1R1, FCGR1A
43vegf4510.6IFNG, GZMB, ICAM1, IL1RN, IL1R1, IL1A
44infliximab45 50 1112.6IL1R1, IL1RN, IFNG
45arginine4510.5KLRK1, IFNG, GZMB, IL1R1, IL1A, TCHH
46cellulose triacetate4510.5IL1RN, IL1A
47peptidoglycan45 2911.4IL1R1, IL1RN, CIITA
48pdtc4510.4IL1A, ICAM1, IFNG
49alanine4510.3CCL27, GZMB, CIITA, MC2R, IL1RN, IL1R1
50interferon gamma4510.2ICAM1, IFNG

GO Terms for genes affiliated with Alopecia Areata

Sources:
16Gene Ontology
See all sources

Cellular components related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4IL1A, IL1RN, IL36RN, TNFSF13, ICAM1, IFNG

Biological processes related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:06033310.5IFNG, ICAM1, CIITA, FCGR1A, FCGR1B
2immune responseGO:00695510.5FCGR1B, CCL27, TNFSF13, CIITA, AIRE, IL1RN
3response to copper ionGO:04668810.5IL1A, ICAM1
4cytokine-mediated signaling pathwayGO:01922110.4IFNG, ICAM1, CIITA, IL1A, FCGR1A, FCGR1B
5positive regulation of MHC class II biosynthetic processGO:04534810.4CIITA, IFNG
6negative regulation of cytokine-mediated signaling pathwayGO:00196010.1IL1RN, IL36RN

Molecular functions related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.4IL1A, IL1RN, IL36RN
2IgG bindingGO:01986410.4FCGR1B, FCGR1A
3interleukin-1 receptor antagonist activityGO:00515210.3IL1RN, IL36RN
4cytokine activityGO:00512510.1IFNG, TNFSF13, IL36RN, IL1A

Products for genes affiliated with Alopecia Areata

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alopecia Areata

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet