AA
MCID: ALP009
MIFTS: 61

Alopecia Areata (AA) malady

Skin diseases category

Summaries for Alopecia Areata

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Alopecia areata is an autoimmune disease in which the immune system mistakenly attacks the hair follicles. this can lead to hair loss on the scalp and elsewhere on the body. in most cases, hair falls out in small, round patches on the scalp. although uncommon, hair loss can be more extensive in some people. this condition can progress to cause total loss of hair on the head (alopecia totalis) or complete loss of hair on the head, face, and body (alopecia universalis). while there is neither a cure for nor drugs approved for treatment, some people find that medications approved for other purposes can help their hair grow back. last updated: 5/9/2011

MalaCards: Alopecia Areata, also known as circumscribed alopecia, is related to alopecia and vitiligo. An important gene associated with Alopecia Areata is AIRE (autoimmune regulator), and among its related pathways are Rheumatoid arthritis and Malaria. The compounds pge2 and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 An autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body initally causing bald spots.

Wikipedia:63 Alopecia areata (AA) is a condition in which hair is lost from some or all areas of the body, usually... more...

Description from OMIM:46 104000,610753

Aliases & Classifications for Alopecia Areata

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8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 46OMIM, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

alopecia areata 8 42 20 22 10 44 60
circumscribed alopecia 8
alopecia circumscripta 42
alopecia cicatrisata 42
cazenave's vitiligo 42
alopecia totalis 60
alopecia celsi 42
aa 42


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Disease Ontology8 DOID:986
ICD9CM27 704.01
ICD1025 L63

Related Diseases for Alopecia Areata

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17GeneCards, 18GeneDecks
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Diseases in the Alopecia Areata family:

Alopecia Areata 2 Alopecia Areata 1

Diseases related to Alopecia Areata via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia32.2AIRE
2vitiligo31.0AIRE, CIITA
3psoriasis31.0IL1A, ICAM1, GZMB, IFNG, CCL27, IL1R1
4dermatitis30.9IFNG, CCL27, ICAM1, IL1A, GZMB
5thyroiditis30.7CIITA
6lichen planus30.7ICAM1, GZMB
7atopic dermatitis30.6FCGR1A, ICAM1, IFNG, CCL27, IL1A
8myasthenia gravis30.5IFNG, AIRE
9diabetes mellitus30.5ICAM1, IL1R1, AIRE
10skin disease30.5CCL27, TCHH, IL1A, CIITA, ICAM1, IFNG
11autoimmune thyroiditis30.3IFNG, ICAM1, CIITA, AIRE
12arthritis30.3ICAM1, IL1A, IL1R1, IL1RN, CIITA, TNFSF13
13thymoma30.3IL1A, AIRE, IL1R1
14rheumatoid arthritis30.3IL1A, GZMB, KLRK1, CCL27, IFNG, FCGR1A
15down syndrome30.3AIRE
16prostate cancer30.1GZMB, FCGR1A, IL1R1
17kawasaki disease30.1CIITA
18thrombocytopenia30.1IL1A, IL1R1
19celiac disease30.1KLRK1, GZMB, CIITA
20hepatitis b30.1GZMB, CIITA, IFNG, CCL27
21hepatitis30.1AIRE, GZMB, CCL27
22keratoconjunctivitis30.1AIRE
23graves' disease30.1IFNG, CIITA, IL1A, IL1RN, ICAM1, AIRE
24ulcerative colitis30.1IL1R1, ICAM1, GZMB, IFNG, IL1A, IL1RN
25uveitis30.1IFNG, ICAM1, IL1R1, IL1A
26acute leukemia30.1FCGR1A
27mycosis fungoides30.1GZMB, CCL27
28systemic lupus erythematosus30.1ICAM1, KLRK1, IFNG, CIITA, TNFSF13, FCGR1A
29leukemia30.1IL1R1, ICAM1, IL1A, IFNG, GZMB, KLRK1
30lymphopenia30.1IL1RN, IFNG, CIITA
31allergic contact dermatitis30.1ICAM1, CCL27
32hepatitis c30.1IL1R1, CIITA, IFNG
33myositis30.0IL1A, GZMB, ICAM1, CIITA, IL1RN
34breast cancer30.0GZMB, CIITA, IL1R1, FCGR1A
35obesity30.0MC2R
36inflammatory bowel disease29.9ICAM1, IL1RN
37influenza29.9GZMB, CIITA, IFNG
38asthma29.9ICAM1, CIITA, IFNG, GZMB
39pneumonia29.9ICAM1
40ovarian cancer29.9IL1A
41sarcoma29.9IL1R1
42polymyalgia rheumatica29.7IL1RN
43malaria29.7ICAM1, IFNG
44schnitzler syndrome29.7IL1RN, IL1R1
45periodontal disease29.7ICAM1
46chorioamnionitis29.7IL1RN, IL1R1
47myeloma29.7ICAM1, KLRK1, CIITA, FCGR1A
48tuberculosis29.7IFNG, CIITA, GZMB, KLRK1
49wegener's granulomatosis29.7CIITA
50relapsing-remitting multiple sclerosis29.7ICAM1, IFNG, IL1RN

Graphical network of the top 20 diseases related to Alopecia Areata:



Diseases related to alopecia areata

Clinical Features for Alopecia Areata

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46OMIM
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Clinical features from OMIM:

104000,610753

Drugs & Therapeutics for Alopecia Areata

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alopecia Areata

Drug clinical trials:

Search ClinicalTrials for Alopecia Areata

Search NIH Clinical Center for Alopecia Areata

Search CenterWatch for Alopecia Areata

Genetic Tests for Alopecia Areata

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20GeneTests, 22GTR
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Genetic tests related to Alopecia Areata:

id Genetic test Affiliating Genes
1 Alopecia Areata20 22

Anatomical Context for Alopecia Areata

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32MalaCards
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MalaCards organs/tissues related to Alopecia Areata:

32
Skin, T cells, Thyroid, Testes, Endothelial, Pituitary, Monocytes, Nk cells, Heart, Thymus, Bone

Animal Models for Alopecia Areata or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alopecia Areata:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4FCGR1A, KLRK1, IFNG, GZMB, ICAM1, TNFSF13
2MP:000537610.4GZMB, ICAM1, CIITA, AIRE, MC2R, IL36RN
3MP:000200610.3KLRK1, IFNG, ICAM1, AIRE, IL1R1
4MP:000538710.3TNFSF13, ICAM1, GZMB, IFNG, KLRK1, CIITA
5MP:000538410.1KLRK1, IFNG, GZMB, ICAM1, TNFSF13, CIITA

Publications for Alopecia Areata

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50PubMed
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Articles related to Alopecia Areata:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Antidepressant effects of citalopram on treatment of alopecia areata in patients with major depressive disorder. (23339335)
2014
2
Mouse alopecia areata and heart disease: know your mouse! (23774530)
2014
3
Genetic analysis of interleukin-1 receptor antagonist and interleukin-1I^ single-nucleotide polymorphisms C-511T and C+3953T in alopecia areata: susceptibility and severity association. (23584371)
2013
4
Summary of the Preceding Three Alopecia Areata Research Summits: What's Past Is Prologue. (24326556)
2013
5
Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in alopecia areata patients. (22591107)
2013
6
Alopecia areata in a patient receiving infliximab. (23760327)
2013
7
Psychosocial impact of wigs or hairpieces on perceived quality of life level in female patients with alopecia areata. (23252418)
2013
8
Pulse corticosteroid therapy for alopecia areata in children: a retrospective study. (24008264)
2013
9
What causes alopecia areata? (23947678)
2013
10
Morphological changes of the hair roots in alopecia areata: A scanning electron microscopic study. (24304217)
2013
11
Targeted photochemotherapy in alopecia areata. (24102724)
2013
12
Efficacy and safety of diphenylcyclopropenone among Chinese patients with steroid resistant and extensive alopecia areata. (23057682)
2013
13
Alopecia Areata And Vitiligo - Partners In Crime Or A Case Of False Alibis. (24372718)
2013
14
Alopecia areata and its effects on patients. (24326550)
2013
15
Videocapillaroscopic alterations in alopecia areata. (24163812)
2013
16
Total glucosides of paeony capsule plus compound glycyrrhizin tablets for the treatment of severe alopecia areata in children: a randomized controlled trial. (24204391)
2013
17
A new humanized mouse model for alopecia areata. (24326548)
2013
18
Topical immunotherapy with diphenylcyclopropenone of patients with alopecia areata--a large retrospective study on 142 patients with a self-controlled design. (21569118)
2012
19
RenbAPk phenomenon in a patient with alopecia areata universalis and psoriasis. (22150402)
2012
20
Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case-control study. (22049923)
2012
21
Investigative guidelines for alopecia areata. (21689240)
2011
22
Dermatologic therapy: Alopecia areata update. (21689237)
2011
23
Environmental stress but not subjective distress in children or adolescents with alopecia areata. (21767691)
2011
24
Alopecia areata incognita: a comment. (21915503)
2011
25
Alopecia areata incognita. (22082840)
2011
26
Collapse of immune privilege in alopecia areata: coincidental or substantial? (20944635)
2010
27
Serum levels of IL-18 and sIL-2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids. (19758343)
2010
28
The TRAF1/C5 locus confers risk for familial and severe alopecia areata. (20030635)
2010
29
Hair transplantation for therapy-resistant alopecia areata of the eyebrows: is it the right choice? (20883369)
2010
30
Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures. (20546884)
2010
31
Could azathioprine be considered as a therapeutic alternative in the treatment of alopecia areata? A pilot study. (20883409)
2010
32
The efficacy of topical diphencyprone in the treatment of alopecia areata. (20049283)
2009
33
Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model. (19175564)
2009
34
Neuroendocrine perspectives in alopecia areata: does stress play a role? (19434088)
2009
35
Acute diffuse and total alopecia: A new subtype of alopecia areata with a favorable prognosis. (18992964)
2009
36
Capsaicin vs. clobetasol for the treatment of localized alopecia areata. (19281605)
2009
37
Value of transverse section scalp biopsy in alopecia areata - a clinicopathological correlation. (18760043)
2008
38
A case of patchy alopecia areata sparing lesional greying hairs. (18717874)
2008
39
Alopecia areata, primary sclerosing cholangitis, and ulcerative colitis: autoimmunity and apoptosis as common links? (17372831)
2007
40
Acquired generalised neuromyotonia, cutaneous lupus erythematosus and alopecia areata in a patient with myasthenia gravis. (17239529)
2007
41
Interferon-gamma in alopecia areata. (14965793)
2004
42
Colocalisation of alopecia areata and lichen planus. (17642625)
2004
43
Therapy of alopecia areata: on the cusp and in the future. (14582675)
2003
44
Borderline tuberculoid leprosy and alopecia areata involving scalp. (12483973)
2002
45
Regrowth of alopecia areata simulating the pattern of androgenetic alopecia. (9006393)
1997
46
HLA class II alleles in long-standing alopecia totalis/alopecia universalis and long-standing patchy alopecia areata differentiate these two clinical groups. (7738393)
1995
47
Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. (8077705)
1994
48
HLA and ICAM-1 expression in alopecia areata in vivo and in vitro: the role of cytokines. (7506926)
1993
49
Nuchal nevi flammei and alopecia areata. (2767300)
1989
50
Alopecia areata associated with neurodermatitis; report of two cases with a discussion of the relationship of alopecia areata to nervous system dysfunction. (18878574)
1948

Genetic Variations for Alopecia Areata

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Expression for genes affiliated with Alopecia Areata

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alopecia Areata

Search GEO for disease gene expression data for Alopecia Areata.

Pathways for genes affiliated with Alopecia Areata

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 53Reactome
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Pathways related to Alopecia Areata according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5TNFSF13
210.5KLRK1
3
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10.5IL1R1, GZMB, IFNG
4
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10.5IFNG, GZMB, IL1R1
510.4IFNG, ICAM1, CIITA
6
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10.4IL1A, IL1R1, IFNG
7
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10.4IL1A, IL1R1, IL1RN
8
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10.4IL1A, IL1R1, IL1RN
910.4IL1R1, IL1A, FCGR1A
10
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10.4IFNG, ICAM1, CIITA, IL1A
11
Immune response Bacterial infections in normal airways
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10.4IFNG, IL1RN, IL1R1, IL1A
1210.4IL1A, IL1R1, TNFSF13, ICAM1
1310.4FCGR1A, IL1A, IL1R1, IFNG
14
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10.4IFNG, CIITA, IL1A, FCGR1A
1510.4IFNG, CIITA, IL1A, FCGR1A
16
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10.4ICAM1, ULBP3, KLRK1
17
Hide members
10.4IFNG, GZMB, ICAM1, TNFSF13, CIITA, IL1A
18
Hide members
10.4KLRK1, ULBP3, IFNG, GZMB, ICAM1
19
Hide members
10.4FCGR1B, FCGR1A, TNFSF13, GZMB, IFNG
20
Hide members
10.4KLRK1, ULBP3, IFNG, ICAM1, CIITA, IL1RN
21
Hide members
10.4FCGR1B, IFNG, ICAM1, CIITA, IL1RN, IL1R1

Compounds for genes affiliated with Alopecia Areata

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Alopecia Areata according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge24410.9CCL27
2pentoxifylline44 1111.9IL1R1, IL1RN
3endotoxin4410.9ICAM1, CIITA
4rantes4410.9IFNG, IL1A, IL1R1, CIITA, ICAM1, GZMB
5gold sodium thiomalate4410.9IL1R1, IL1RN, IFNG, IL1A
6neopterin4410.9IL1A, IL1R1, IL1RN, ICAM1, GZMB, IFNG
7prednisolone44 28 1112.9IL1R1, FCGR1A, GZMB
8ivig4410.9IFNG, GZMB, IL1RN, IL1R1, IL1A, FCGR1A
9hydrocortisone44 2 59 1113.9MC2R
10cycloheximide4410.9FCGR1A
11adalimumab44 49 1112.9IL1RN, IL1R1, FCGR1A, IFNG
12sulfasalazine44 28 49 1113.9ICAM1, IL1A, IL1RN, IL1R1
13polymyxin b4410.9IL1A, IL1RN, ICAM1, IFNG
14ccl344 2811.8ICAM1, IFNG, CCL27, IL1R1, IL1A
15polyinosinic-polycytidylic acid4410.8IL1A, CIITA, IFNG, KLRK1
16cyclosporin a44 28 5912.8IL1RN, IL1R1, CIITA, IL1A, ICAM1, GZMB
17etanercept44 49 1112.8IL1RN, IL1R1, IFNG, FCGR1A
18sb 20358044 5911.8AIRE, IL1RN, ICAM1, IFNG, IL1R1, IL1A
19dexamethasone44 49 28 1113.8FCGR1A, CCL27, GZMB, CIITA, MC2R, IL1R1
20ribonucleic acid4410.8GZMB, CIITA, MC2R, IL1R1, IL1A, FCGR1A
21pirfenidone44 5911.8IL1A
22il 104410.8IL1RN, IL1A, IFNG, IL1R1
23simvastatin44 49 59 28 11 2415.8CIITA, IL1RN, IFNG, ICAM1, IL1A
24hyaluronic acid44 2411.8GZMB, ICAM1, IL1A, IL1RN, IL1R1
25natalizumab44 1111.8ICAM1, IFNG, FCGR1A
26tarc4410.8IFNG, ICAM1, IL1A, CCL27
27amphotericin b4410.8IL1R1, IFNG, IL1RN
28allergens4410.8CIITA, IL1RN, IFNG, CCL27
29actinomycin d4410.8IL1R1, CIITA, IL1A, IFNG, FCGR1A, ICAM1
30polyethylene glycol4410.8IL1RN, IL1R1, ICAM1, IL1A
31minocycline44 1111.8CIITA, IL1A, ICAM1
322-chloroethyl ethyl sulfide4410.8IL1RN, IL1A
33sodium dodecylsulfate4410.7IL1RN, CIITA, IL1R1, IL1A
34nitric oxide44 11 2412.7CIITA, ICAM1, GZMB, IFNG, IL1A, IL1R1
35cuprophan4410.7ICAM1, IL1RN, IL1R1
36gm-csf44 2811.7IFNG, ICAM1
37oxygen44 2411.7FCGR1A, CIITA, KLRK1, ICAM1
38retinoic acid44 2411.7IL1R1, IL1A, IFNG, ICAM1, IL1RN, KLRK1
39herbimycin a44 5911.6IFNG, FCGR1A, IL1A, ICAM1
40calcium44 49 11 2413.6KLRK1, GZMB, ULBP3, CCL27, CIITA, MC2R
41fmlp4410.6IL1RN, FCGR1A, IL1A, ICAM1
42cholesterol44 28 11 2413.6MC2R, IL1R1, FCGR1A, IL1RN, CIITA, CCL27
43vegf4410.6IL1A, IL1R1, IL1RN, GZMB, IFNG, ICAM1
44infliximab44 49 1112.6IL1R1, IL1RN, IFNG
45arginine4410.5KLRK1, TCHH, IL1A, IL1R1, GZMB, IFNG
46cellulose triacetate4410.5IL1A, IL1RN
47peptidoglycan44 2811.4IL1RN, CIITA, IL1R1
48pdtc4410.4IFNG, ICAM1, IL1A
49alanine4410.3MC2R, IL1RN, IL1R1, CCL27, CIITA, GZMB
50interferon gamma4410.2IFNG, ICAM1

GO Terms for genes affiliated with Alopecia Areata

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16Gene Ontology
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Cellular components related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4IL1A, IL1RN, IL36RN, TNFSF13, ICAM1, IFNG

Biological processes related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:06033310.5IFNG, ICAM1, CIITA, FCGR1A, FCGR1B
2immune responseGO:00695510.5FCGR1B, CCL27, TNFSF13, CIITA, AIRE, IL1RN
3response to copper ionGO:04668810.5IL1A, ICAM1
4cytokine-mediated signaling pathwayGO:01922110.4IFNG, ICAM1, CIITA, IL1A, FCGR1A, FCGR1B
5positive regulation of MHC class II biosynthetic processGO:04534810.4CIITA, IFNG
6negative regulation of cytokine-mediated signaling pathwayGO:00196010.1IL1RN, IL36RN

Molecular functions related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.4IL1A, IL1RN, IL36RN
2IgG bindingGO:01986410.4FCGR1B, FCGR1A
3interleukin-1 receptor antagonist activityGO:00515210.3IL1RN, IL36RN
4cytokine activityGO:00512510.1IFNG, TNFSF13, IL36RN, IL1A

Products for genes affiliated with Alopecia Areata

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  • Antibodies
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Sources for Alopecia Areata

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet