AA
MCID: ALP009
MIFTS: 65

Alopecia Areata (AA) malady

Genetic diseases, Rare diseases, Skin diseases, Immune diseases categories
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Summaries for Alopecia Areata

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NIH Rare Diseases:42 Alopecia areata is an autoimmune disease in which the immune system mistakenly attacks the hair follicles. this can lead to hair loss on the scalp and elsewhere on the body. in most cases, hair falls out in small, round patches on the scalp. although uncommon, hair loss can be more extensive in some people. this condition can progress to cause total loss of hair on the head (alopecia totalis) or complete loss of hair on the head, face, and body (alopecia universalis). while there is neither a cure for nor drugs approved for treatment, some people find that medications approved for other purposes can help their hair grow back. last updated: 5/9/2011

MalaCards based summary: Alopecia Areata, also known as circumscribed alopecia, is related to alopecia and thyroiditis. An important gene associated with Alopecia Areata is AIRE (autoimmune regulator), and among its related pathways are Primary immunodeficiency and Downstream signaling in naive CD8+ T cells. The compounds 2-chloroethyl ethyl sulfide and pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Disease Ontology:8 A hypersensitivity reaction type ii disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots.

Wikipedia:65 Alopecia areata (AA) is a condition in which hair is lost from some or all areas of the body, usually... more...

Descriptions from OMIM:46 610753,104000

Aliases & Classifications for Alopecia Areata

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Alopecia Areata, Aliases & Descriptions:

Name: Alopecia Areata 8 42 20 22 10 44 62
Circumscribed Alopecia 8 62
Alopecia Circumscripta 42 62
Alopecia Cicatrisata 42 62
Cazenave's Vitiligo 42 62
Jonston's Alopecia 42 62
 
Marginal Alopecia 42 62
Celsus' Vitiligo 42 62
Diffuse Alopecia 42 62
Alopecia Celsi 42 62
Patchy Alopecia 42
Aa 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:986
ICD9CM27 704.01
ICD1025 L63

Related Diseases for Alopecia Areata

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Diseases in the Alopecia Areata family:

Alopecia Areata 2 Alopecia Areata 1

Diseases related to Alopecia Areata via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 353)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia33.1AIRE
2thyroiditis31.6CIITA
3vitiligo31.5CIITA, AIRE
4lichen planus31.2GZMB, ICAM1
5dermatitis30.9ICAM1, IFNG, IL1A, GZMB
6myasthenia gravis30.9AIRE, IFNG
7atopic dermatitis30.8ICAM1, IFNG, IL1A
8candidiasis30.8IFNG, AIRE
9thymoma30.7AIRE, IL1R1, IL1A
10aplastic anemia30.6IFNG, GZMB
11hypothyroidism30.6IL1A, AIRE
12oral lichen planus30.5ICAM1, IL1A
13psoriasis30.5IL1A, IL1R1, IFNG, GZMB, ICAM1, CIITA
14skin disease30.5IL1A, GZMB
15type 1 diabetes mellitus30.5IL1R1, CIITA, AIRE
16celiac disease30.4CIITA, GZMB
17hepatitis b30.4IFNG, CIITA, GZMB
18diabetes mellitus30.4IL1R1, ICAM1, AIRE
19periodontal disease30.4ICAM1
20periodontitis30.4IL1A
21colitis30.3IL1RN, IL1R1, IFNG
22lymphopenia30.3IFNG, CIITA, IL1RN
23malaria30.2IFNG, ICAM1
24autoimmune thyroiditis30.2CIITA, IFNG, ICAM1, AIRE
25influenza30.2IFNG, CIITA, GZMB
26rheumatic disease30.1IL1RN, IL1R1
27schnitzler syndrome30.1IL1R1, IL1RN
28uveitis30.1ICAM1, IL1R1, IL1A, IFNG
29chorioamnionitis30.1IL1RN, IL1R1
30ankylosing spondylitis30.0IL1R1, IL1RN
31tuberculosis30.0GZMB, IFNG, CIITA
32asthma29.9GZMB, IFNG, ICAM1, CIITA
33leukemia29.8IL1R1, IFNG, GZMB, IL1A, ICAM1
34relapsing-remitting multiple sclerosis29.8IL1RN, ICAM1, IFNG
35septic shock29.8IL1RN, CIITA, IL1A, IL1R1
36sepsis29.8IL1R1, CIITA, IL1A, IL1RN
37sarcoidosis29.7ICAM1, IFNG, GZMB, IL1RN, IL1A
38myositis29.7ICAM1, IL1A, CIITA, GZMB, IL1RN
39inflammatory bowel disease29.6IL1RN, CIITA, ICAM1, IFNG, IL1R1
40ulcerative colitis29.5IFNG, IL1R1, IL1RN, IL1A, ICAM1, GZMB
41arthritis29.5ICAM1, IL1R1, IL1RN, IFNG, GZMB, CIITA
42systemic lupus erythematosus29.4IL1RN, ICAM1, FCRL3, IFNG, CIITA, IL1R1
43melanoma29.4ICAM1, IFNG, CIITA, IL1A, GZMB
44multiple sclerosis29.3CIITA, ICAM1, IL1RN, IL1R1, IFNG
45graves' disease29.1FCRL3, AIRE, IL1RN, IFNG, ICAM1, CIITA
46rheumatoid arthritis29.1ICAM1, FCRL3, GZMB, IL1A, IL1RN, IL1R1
47amyloidosis10.9
48alopecia universalis10.8
49androgenetic alopecia10.7
50alopecia totalis10.7

Graphical network of the top 20 diseases related to Alopecia Areata:



Diseases related to alopecia areata

Symptoms for Alopecia Areata

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Clinical features from OMIM:

610753,104000

Drugs & Therapeutics for Alopecia Areata

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Drug clinical trials:

Search ClinicalTrials for Alopecia Areata

Search NIH Clinical Center for Alopecia Areata

Genetic Tests for Alopecia Areata

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Genetic tests related to Alopecia Areata:

id Genetic test Affiliating Genes
1 Alopecia Areata20 22

Anatomical Context for Alopecia Areata

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MalaCards organs/tissues related to Alopecia Areata:

32
Skin, T cells, Thyroid, Testes, Endothelial, Pituitary, Bone, Thymus, Heart, Monocytes, Nk cells

Animal Models for Alopecia Areata or affiliated genes

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MGI Mouse Phenotypes related to Alopecia Areata:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.6IL1R1, ICAM1, CIITA, AIRE, IFNG
2MP:00020068.3AIRE, ICAM1, IL1R1, IL1A, GZMB, IFNG
3MP:00107717.7IFNG, ICAM1, IL36RN, IL1R1, IL1RN
4MP:00053847.7AIRE, GZMB, IL1RN, IL1R1, IFNG, ICAM1
5MP:00053787.5AIRE, IL1RN, IL1R1, IFNG, IL36RN, ICAM1
6MP:00053857.4IL1A, ICAM1, IFNG, IL36RN, IL1R1, IL1RN
7MP:00107687.3IL1R1, IL36RN, IFNG, AIRE, ICAM1, GZMB
8MP:00053976.5IFNG, IL1A, AIRE, CIITA, IL1RN, IL36RN
9MP:00053876.5IL1A, ICAM1, AIRE, GZMB, IL1RN, IL1R1
10MP:00053766.5GZMB, IL36RN, IL1A, IL1R1, ICAM1, CIITA

Publications for Alopecia Areata

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Articles related to Alopecia Areata:

(show top 50)    (show all 633)
idTitleAuthorsYear
1
The Association of Lacrimal Gland Inflammation with Alopecia Areata. (25280049)
2014
2
Trichostasis spinulosa of the scalp mimicking Alopecia areata black dots. (25054768)
2014
3
The Autoimmune Basis of Alopecia Areata: A Comprehensive Review. (25315746)
2014
4
Pulse methylprednisolone therapy for the treatment of extensive alopecia areata. (23336179)
2014
5
Gene Expression of Osteopontin in Alopecia Areata? A Case-Controlled Study. (25322767)
2014
6
Genetic analysis of interleukin-1 receptor antagonist and interleukin-1I^ single-nucleotide polymorphisms C-511T and C+3953T in alopecia areata: susceptibility and severity association. (23584371)
2013
7
Alopecia areata associated with Herpes zoster. (23682830)
2013
8
Therapy for alopecia areata in mice using parathyroid hormone agonists and antagonists, linked to a collagen-binding domain. (24326563)
2013
9
Alopecia areata - Vitiligo overlap syndrome: an emerging clinical variant. (23760330)
2013
10
Summary of the Preceding Three Alopecia Areata Research Summits: What's Past Is Prologue. (24326556)
2013
11
Growth hormone deficiency in a young patient with alopecia areata. (24326559)
2013
12
Universal protocol for alopecia areata clinical studies. (24326554)
2013
13
Early stage alopecia areata is associated with inflammation in the upper dermis and damage to the hair follicle infundibulum. (23808570)
2013
14
Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in alopecia areata patients. (22591107)
2013
15
Alopecia areata in a patient receiving infliximab. (23760327)
2013
16
Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata. (24194967)
2013
17
Alopecia areata during treatment with adalimumab: therapy with an alternative TNF-alpha inhibitor is possible. (23279686)
2013
18
Practice gaps. Alopecia areata and comorbid conditions. (23699633)
2013
19
Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship? (23329992)
2012
20
General practitioners' knowledge and practices related to alopecia areata in Qassim region, Saudi Arabia. (22415332)
2012
21
Association between scalp psoriasis and alopecia areata. (22535354)
2012
22
Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. (22930385)
2012
23
Amelanocytic anhidrotic alopecia areata-like phenotype after allogeneic hematopoietic cell transplant. (22911189)
2012
24
RenbAPk phenomenon in a patient with alopecia areata universalis. (22911207)
2012
25
No filaggrin gene mutation in a patient with a combination of atopic dermatitis, alopecia areata and food allergy. (23174665)
2012
26
Investigative guidelines for alopecia areata. (21689240)
2011
27
Oral erosive lichen planus and alopecia areata with Good's syndrome (thymoma with hypogammaglobulinemia). (21282092)
2011
28
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (20596022)
2010
29
Bimatoprost in the treatment of eyelash universalis alopecia areata. (21712909)
2010
30
Serum concentrations of interferon-gamma (IFN-g) in patients with alopecia areata: correlation with clinical type and duration of the disease. (21246917)
2010
31
Management of alopecia areata. (20656774)
2010
32
Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity. (20535136)
2010
33
Is Helicobacter pylori infection associated with alopecia areata? (19250167)
2009
34
Treatment of alopecia areata in children. (19685659)
2009
35
Alopecia areata is not associated with Helicobacter pylori. (20049262)
2009
36
Development of alopecia areata is associated with higher central and peripheral hypothalamic-pituitary-adrenal tone in the skin graft induced C3H/HeJ mouse model. (19020552)
2009
37
History of atopy or autoimmunity increases risk of alopecia areata. (19608295)
2009
38
Lack of efficacy of topical imiquimod in the treatment of patchy alopecia areata. (18986369)
2008
39
Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample. (18986440)
2008
40
Poor long term outcome of severe alopecia areata in children treated with high dose pulse corticosteroid therapy. (18279461)
2008
41
Alopecia areata and autoimmunity. (18833068)
2008
42
Susceptible and protective endothelial nitric oxide synthase gene polymorphism in alopecia areata in the Kuwaiti population. (18608176)
2008
43
Serum selenium level in Iranian patients with alopecia areata. (18452532)
2008
44
In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101. (15953089)
2005
45
Extensive alopecia areata treated with betamethasone oral mini-pulse therapy: an open uncontrolled study. (17642661)
2004
46
Clinical evolution of alopecia areata with a male androgenetic alopecia pattern to sisaipho. (10694313)
2000
47
Equine alopecia areata autoantibodies target multiple hair follicle antigens and may alter hair growth. A preliminary study. (9832317)
1998
48
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
49
Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice. (1536782)
1992
50
Natural killer cell and cytotoxic/suppressor T cell deficiency in peripheral blood in subjects with alopecia areata. (3250436)
1988

Variations for Alopecia Areata

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Expression for genes affiliated with Alopecia Areata

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Expression patterns in normal tissues for genes affiliated with Alopecia Areata

Search GEO for disease gene expression data for Alopecia Areata.

Pathways for genes affiliated with Alopecia Areata

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Pathways related to Alopecia Areata according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CIITA, AIRE
2
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.7GZMB, IFNG
3
Show member pathways
9.7IFNG, GZMB
49.6IFNG, ICAM1
59.6ICAM1, IFNG
69.6ICAM1, IFNG
79.6ICAM1, IFNG
89.5IL1A, IFNG
99.5IL1A, IFNG
109.5IL1A, IFNG
11
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.4IL1RN, IFNG
12
Show member pathways
9.4GZMB, IL1R1, IFNG
13
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.4GZMB, IL1R1, IFNG
14
Show member pathways
Immune response CD16 signaling in NK cells60
9.3ICAM1, IFNG, GZMB
159.2CIITA, ICAM1, IFNG
16
Show member pathways
9.2IL1A, IL1R1, IFNG
17
Show member pathways
9.2IL1A, IL1R1, IFNG
189.2IL1A, IL1R1, IFNG
19
Show member pathways
Immune response MIF in innate immunity response60
9.2IFNG, IL1R1, IL1A
20
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2IFNG, IL1R1, IL1A
219.2IFNG, IL1R1, IL1A
229.1IL1A, IFNG, CIITA
23
Show member pathways
9.1CIITA, IFNG, IL1A
249.1IL1A, IFNG, ICAM1
25
Show member pathways
9.0IL1A, IL1RN, IL1R1
26
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
9.0IL1A, IL1RN, IL1R1
278.7ICAM1, IFNG, IL1R1, IL1A
28
Show member pathways
8.7CIITA, ICAM1, IFNG, IL1A
29
Show member pathways
8.4CIITA, ICAM1, IFNG, IL1A, GZMB
30
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.2IL36RN, IL1R1, IL1RN, IL1A
31
Show member pathways
7.7IL1A, IL1RN, IL1R1, IFNG, ICAM1, CIITA

Compounds for genes affiliated with Alopecia Areata

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Compounds related to Alopecia Areata according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
12-chloroethyl ethyl sulfide449.7IL1A, IL1RN
2pirfenidone44 6110.5IFNG, IL1R1, IL1A
3minocycline44 1110.5CIITA, ICAM1, IL1A
4polyinosinic-polycytidylic acid449.4IL1A, CIITA, IFNG
5cuprophan449.4ICAM1, IL1R1, IL1RN
6amphotericin b449.4IL1RN, IFNG, IL1R1
7gm-csf44 2810.4IFNG, ICAM1, IL1A
8adalimumab44 50 1111.4IL1RN, IFNG, IL1R1
9cellulose triacetate449.4IL1RN, IL1A
10peptidoglycan44 2810.4IL1RN, IL1R1, CIITA
11etanercept44 50 1111.4IFNG, IL1RN, IL1R1
12tarc449.3IL1A, IFNG, ICAM1
13infliximab44 50 1111.3IFNG, IL1R1, IL1RN
14pdtc449.2IFNG, IL1A, ICAM1
15allergens449.2CIITA, IFNG, IL1RN
16thalidomide44 50 61 1112.2IL1R1, IL1A, IFNG
17ccl344 2810.1IL1A, IL1R1, ICAM1, IFNG
18prednisolone44 28 1111.1IL1RN, GZMB, IL1R1, IFNG
19chloroquine44 2 50 28 1113.0CIITA, IL1R1, IL1RN
20rapamycin449.0IFNG, GZMB, IL1A, IL1R1
21sodium dodecylsulfate449.0IL1A, IL1R1, CIITA, IL1RN
22sulfasalazine28 44 50 1112.0IL1R1, IL1RN, IL1A, ICAM1
23corticosterone44 61 2411.0IL1RN, IL1A, IL1R1
24polyethylene glycol449.0IL1A, IL1RN, ICAM1, IL1R1
25gold sodium thiomalate449.0IFNG, IL1R1, IL1RN, IL1A
26il 10448.9IL1RN, IL1R1, IL1A, IFNG
27polymyxin b448.9IL1A, IFNG, IL1RN, ICAM1
28hydrocortisone44 2 61 1111.9IL1A, IFNG, IL1R1, IL1RN
29ascorbic acid44 249.9IL1A, IL1RN, ICAM1, IL1R1
30indomethacin44 28 61 1111.8IFNG, IL1A, IL1RN, IL1R1
31actinomycin d448.8IFNG, IL1R1, CIITA, ICAM1, IL1A
32ribonucleic acid448.7CIITA, IL1RN, IL1A, GZMB, IL1R1
33hyaluronic acid44 249.7ICAM1, IL1R1, IL1RN, IL1A, GZMB
34ivig448.7IL1R1, IFNG, GZMB, IL1RN, IL1A
35pentoxifylline44 119.6ICAM1, IL1RN, IL1A, IFNG, IL1R1
36simvastatin44 50 61 28 24 1113.5CIITA, IL1A, IL1RN, IFNG, ICAM1
37sb 20358044 619.3IL1RN, AIRE, ICAM1, IFNG, IL1R1, IL1A
38neopterin448.3IL1A, IL1RN, IFNG, IL1R1, GZMB, ICAM1
39tyrosine448.2IL1RN, ICAM1, CIITA, GZMB, IL1R1, AIRE
40serine448.2IL1RN, AIRE, CIITA, GZMB, IL1R1, IL1A
41endotoxin448.2IL1A, ICAM1, CIITA, IFNG, IL1R1, IL1RN
42vegf448.2IL1A, ICAM1, IL1RN, IL1R1, IFNG, GZMB
43pge2448.2IL1R1, IL1A, IL1RN, ICAM1, IFNG, CIITA
44cycloheximide448.2IL1A, CIITA, ICAM1, IFNG, IL1R1, IL1RN
45retinoic acid44 249.1GZMB, IL1RN, IL1A, ICAM1, IL1R1, IFNG
46oxygen44 249.1GZMB, CIITA, IL1RN, IL1R1, ICAM1
47rantes447.9ICAM1, IL1R1, IL1RN, IL1A, GZMB, IFNG
48cyclosporin a44 28 619.9GZMB, IL1A, IL1RN, IFNG, ICAM1, CIITA
49dexamethasone44 50 28 1110.9GZMB, IFNG, IL1R1, ICAM1, IL1RN, IL1A
50nitric oxide44 24 119.9CIITA, IL1A, IL1RN, IL1R1, IFNG, ICAM1

GO Terms for genes affiliated with Alopecia Areata

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Cellular components related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immunological synapseGO:0017729.7GZMB, ICAM1
2extracellular spaceGO:0056157.3IL1A, IL1RN, IL36RN, IFNG, ICAM1

Biological processes related to Alopecia Areata according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.8CIITA, IFNG
2humoral immune responseGO:0069599.7IFNG, AIRE
3response to copper ionGO:0466889.6IL1A, ICAM1
4fever generationGO:0016609.5IL1A, IL1RN
5positive regulation of nitric oxide biosynthetic processGO:0454299.5IFNG, ICAM1
6interferon-gamma-mediated signaling pathwayGO:0603339.4IFNG, ICAM1, CIITA
7negative regulation of cytokine-mediated signaling pathwayGO:0019609.1IL1RN, IL36RN
8cytokine-mediated signaling pathwayGO:0192218.9CIITA, ICAM1, IFNG, IL1A
9positive regulation of transcription from RNA polymerase II promoterGO:0459448.8AIRE, CIITA, IFNG, IL1A
10response to drugGO:0424938.7IL1RN, IFNG, ICAM1
11immune responseGO:0069558.6IL1A, IL1RN, IL1R1, CIITA, AIRE

Molecular functions related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor antagonist activityGO:0051528.7IL1RN, IL36RN
2cytokine activityGO:0051258.7IL1A, IL36RN, IFNG
3interleukin-1 receptor bindingGO:0051498.4IL1A, IL1RN, IL36RN

Products for genes affiliated with Alopecia Areata

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Sources for Alopecia Areata

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3CDC
13ExPASy
14FMA
22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
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29KEGG
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