Alopecia Areata malady

Disease Ontology: An autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body initally causing bald spots.⁶

MalaCards: Alopecia Areata, also known as alopecia totalis, is related to alopecia universalis and atopic dermatitis. An important gene associated with Alopecia Areata is AA1 (Alopecia areata 1), and among its related pathways are Cell adhesion molecules (CAMs) and Antigen processing and presentation. The compounds ivig and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, skin and monocytes, and related mouse phenotypes are respiratory system and craniofacial.

Wikipedia: Alopecia areata (AA) is a medical condition in which hair is lost from some or all areas of the body,...⁴⁴ more...

Aliases & Descriptions:

alopecia areata 6 16 8 32 43 alopecia totalis 16 43

circumscribed alopecia 6

Disease types for alopecia areata family:

alopecia areata 1	alopecia areata 2

Diseases related to alopecia areata by text searches and GeneDecks gene sharing:

(show top 50)    (show all 836)

id	Related Disease	Score	Top Affiliating Genes
1	alopecia universalis	31.4	INS, IFNG, AIRE, TNF
2	atopic dermatitis	27.3	CD40, FLG, MIF, FCGR1A, IL10, IL16
3	down syndrome	23.0	MX1, XDH, CD79A, INS, IL10, IL1A
4	atopy	22.7	VDR, CIITA, CD79A, FLG, MIF, FCGR1A
5	alopecia	22.4	VDR, BIRC5, ULBP3, CIITA, MX1, XDH
6	dermatitis	21.9	CIITA, MX1, CD79A, CD40, GZMB, FLG
7	diabetes mellitus	17.2	VDR, CIITA, XDH, T, CD79A, CDKN2A
8	thyroiditis	16.2	VDR, BIRC5, CIITA, XDH, CD79A, CDKN2A
9	contact dermatitis	13.8	FLG, IL1A, KRT16, CXCL9
10	allergic contact dermatitis of eyelid	13.8	FLG, CCL27, ICAM1, CXCL9
11	exanthem	13.8	GZMB, CCL27, CCL11
12	childhood type dermatomyositis	13.8	HLA-DQA1, HLA-DQA2, STX17
13	rheumatoid arthritis	13.7	CIITA, HLA-DRB1, PTPN22
14	henoch-schoenlein purpura	13.7	MX1, CD79A, ICAM1
15	radiculopathy	13.6	IL1A, IL1R1, IL2RA, CXCL9
16	mhc class i deficiency	13.6	IFNG, HLA-B, KLRK1
17	somatoform disorder	13.6	IL1A, IL1B, IL1RN, MC2R
18	tubulointerstitial nephritis and uveitis	13.6	HLA-DQA1, HLA-DQB1, HLA-DRB1
19	temporal arteritis	13.6	MX1, CCL2, IFNG
20	meningococcemia	13.6	IL1A, IL1B, IL1RN, CCL5
21	pars planitis	13.6	IL1RN, HLA-A, HLA-B, HLA-DRB1
22	nodular goiter	13.5	IFNG, ICAM1, TPO
23	postherpetic neuralgia	13.5	HLA-A, HLA-B, HLA-DRB1
24	cerebral artery occlusion	13.5	IL16, IL1RN, ICAM1, NOS3, NES
25	chronic eosinophilic pneumonia	13.5	IL10, CCL11, CXCL9
26	chronic infantile neurological cutaneous articular syndrome	13.5	IL1B, IL1R1, IL1RN, TNFRSF1A
27	idiopathic myopathy	13.5	IL1A, IL1R1, CCL2, CCL5, HLA-B
28	hypothyroidism, autoimmune	13.5	IL2RA, AIRE, TPO, CTLA4, CXCL9
29	cervical dystonia	13.5	HLA-DQA1, HLA-DQB1, HLA-DRB1
30	familial cold autoinflammatory syndrome	13.5	IL1B, IL1R1, TNFRSF1A
31	tuberculoid leprosy	13.5	IL10, IL2RA, IFNG
32	pelvic inflammatory disease	13.5	CCL2, IFNG, HLA-DQA1, HLA-DQB1
33	lymphadenitis	13.5	IL2, FASLG, ICAM1, CXCL9
34	schnitzler syndrome	13.5	IL1A, IL1R1, IL1RN, TNF
35	african tick-bite fever	13.5	IL10, CCL5, IFNG
36	berylliosis	13.5	IL2, IFNG, HLA-DRB1
37	t-cell large granular lymphocyte leukemia	13.5	GZMB, IL2, FASLG
38	common cold	13.4	IL1R1, IL8, CCL11, ICAM1
39	basal cell carcinoma	13.4	VDR, GZMB, FASLG, KRT16, TCHH
40	eosinophilic pneumonia	13.4	IL3, CCL11, CCL5
41	adult glioblastoma multiforme	13.4	HLA-A, HLA-B, HLA-C, HLA-DRB1
42	whipple disease	13.4	IL16, HLA-B, HLA-DQB1, HLA-DRB1
43	cryptosporidiosis	13.4	IL1A, IL4, CCL11, CCL5
44	aplastic anemia	13.4	GZMB, IL3, FASLG, FAS, IFNG
45	stachybotrys chartarum	13.4	IL1A, IL1B, IL3, CCL4
46	bullous pemphigoid	13.3	CIITA, CD79A, FLG, CCL11, CCL5, HLA-DQB1
47	chronic inflammatory demyelinating polyneuropathy	13.3	AIRE, TNF, CTLA4, CXCL9
48	myxedema	13.3	CD79A, TPO, CTLA4
49	relapsing-remitting multiple sclerosis	13.3	MX1, IL10, IL1RN, IL2RA, CCL5, IFNG
50	marginal zone b-cell lymphoma	13.3	CD79A, CDKN2A, FAS, AIRE

Approved drugs:

Drug clinical trials:

Genetic tests related to alopecia areata:

id	Genetic test	Affiliating Genes
1	Alopecia Areata clinical/research

MalaCards organs/tissues related to alopecia areata:

²²

MGI Mouse Phenotypes related to alopecia areata:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	C5, PTPN22
2	craniofacial phenotype	MP:0005382	10.1	PSIP1, KRT16, FLG, T
3	endocrine/exocrine gland phenotype	MP:0005379	9.6	PSIP1, CTLA4, TMPO, AIRE, IFNG, FASLG
4	hematopoietic system phenotype	MP:0005397	9.1	GZMB, FLG, MIF, IL21, IL3, CCL11
5	renal/urinary system phenotype	MP:0005367	9.1	EGFR, NOS3, INS
6	integument phenotype	MP:0010771	8.7	IFNG, TNFRSF1A, TMPO, CTLA4, KRT16, EGFR
7	skeleton phenotype	MP:0005390	8.3	C5, PSIP1, EGFR, CTLA4, TNFRSF1A, FAS
8	nervous system phenotype	MP:0003631	8.1	NES, TGFB1, EGFR, NOTCH4, TNFRSF1A, HLA-DQB1
9	reproductive system phenotype	MP:0005389	8.0	PSIP1, TGFB1, TNFRSF1A, TNF, F8, IFNG
10	liver/biliary system phenotype	MP:0005370	8.0	CTLA4, NOS3, EGFR, SOD1, PTPN22, AIRE
11	digestive/alimentary phenotype	MP:0005381	7.9	TMPO, CTLA4, NOS3, KRT16, EGFR, TGFB1
12	behavior/neurological phenotype	MP:0005386	7.5	AIRE, HLA-C, HLA-DQB1, TNFRSF1A, NOS3, KRT16
13	growth/size phenotype	MP:0005378	7.2	TPO, PTPN22, NOS3, NOTCH4, KRT16, EGFR
14	immune system phenotype	MP:0005387	7.2	VDR, TNF, TNFRSF1A, PTPN22, EGFR, ACP1
15	mortality/aging	MP:0010768	7.2	HLA-DQB1, TPO, TNFRSF1A, PTPN22, CTLA4, NOS3
16	adipose tissue phenotype	MP:0005375	7.0	PSIP1, TGFB1, EGFR, NOS3, TNFRSF1A, TNF
17	normal phenotype	MP:0002873	6.8	CCL11, IFNG, AIRE, HLA-DQB1, TNFSF13, CTLA4
18	tumorigenesis	MP:0002006	6.6	IFNG, ICAM1, AIRE, TNF, TNFRSF1A, KLRK1
19	vision/eye phenotype	MP:0005391	5.6	AIRE, TNF, TNFRSF1A, NOS3, EGFR, TGFB1
20	cardiovascular system phenotype	MP:0005385	5.0	TNF, HLA-DQB1, ICAM1, IFNG, TNFRSF1A, CTLA4
21	homeostasis/metabolism phenotype	MP:0005376	4.8	VDR, BIRC5, CIITA, XDH, T, CD79A
22	cellular phenotype	MP:0005384	3.1	FAS, NOS3, KLRK1, EGFR, ACP1, TGFB1

Articles related to alopecia areata:

(show top 50)    (show all 73)

id	Title	Authors	Year	Affiliating Genes
1	Genetic variants in CTLA4 are strongly associated wit h alopecia areata. (21346773)	John K.K.... Betz R.C.	2011	CTLA4
2	Hair follicle stem cell marker nestin expression in r egenerating hair follicles of patients with alopecia areata. (21524985)	Amoh Y.... Katsuoka K.	2011	NES
3	Serum Interleukin-4 and Total Immunoglobulin E in Non atopic Alopecia Areata Patients and HLA-DRB1 Typing. (20671941)	Attia E.A.... Sefin A.	2010	HLA-DRB1
4	Serum T helper 1 cytokine levels are greater in patie nts with alopecia areata regardless of severity or atopy. (19874320)	Barahmani N.... Duvic M.	2010	IFNG
5	Genome-wide association study in alopecia areata impl icates both innate and adaptive immunity. (20596022)	Petukhova L.... Christiano A.M.	2010	IL2RA, IL2, PRDX5
6	Melanocortin receptor type 2 (MC2R, ACTH receptor) ex pression in patients with alopecia areata. (20590821)	Guo H.W.... Hao F.	2010	MC2R
7	Trichohyalin is a potential major autoantigen in huma n alopecia areata. (20722389)	Leung M.C.... Tobin D.J.	2010	KRT16, TCHH
8	Trichomegaly in a 3-year-old girl with alopecia areata. (19419469)	Nazareth M.R.... Rothman I.L.	2009	EGFR
9	Regulatory effect of procyanidins on the expressions of interferon-gamma, interleukin-12 and transcription factor T-bet mRNA in peripheral blood mononuclear cell of patients with alopecia areata (19123327)	Zhu P.C.... Chen D.C.	2008	IFNG, T
10	The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata. (18028494)	Betz R.C.... Nothen M.M.	2008	ACP1, PTPN22
11	Vitamin D receptor gene polymorphisms are not associated with alopecia areata. (17822494)	Akar A.... Kurumlu Z.	2007	VDR
12	Loss-of-function mutations in the filaggrin gene and alopecia areata: strong risk factor for a severe course of disease in patients comorbid for atopic disease. (17581619)	Betz R.C.... Nothen M.M.	2007	FLG
13	Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata. (17124586)	Kuwano Y.... Tamaki K.	2007	FCGR1A, FCGR1B
14	In vivo levels of IL-4, IL-10, TGF-beta1 and IFN-gamma mRNA of the peripheral blood mononuclear cells in patients with alopecia areata in comparison to those in patients with atopic dermatitis. (17021766)	Katagiri K.... Hatano Y.	2007	IL4, IFNG, IL10
15	Serum chemokine profiles in patients with alopecia areata. (17489976)	Kuwano Y.... Tamaki K.	2007	CCL2, IL8, IFNG
16	Earlier occurrence of severe alopecia areata in HLA-DRB1*11-positive patients. (16778420)	Marques Da Costa C.... Stene J.J.	2006	HLA-DRB1
17	Major histocompatibility complex class I chain-related gene A polymorphisms and extended haplotypes are associated with familial alopecia areata. (16417220)	Barahmani N.... Duvic M.	2006	HLA-A, MICA
18	Investigation of the HLA-DRB1 locus in alopecia areata. (16935791)	Entz P.... Nothen M.M.	2006	HLA-DRB1
19	Analysis of the monocyte chemoattractant protein 1 -2518 promoter polymorphism in Korean patients with alopecia areata. (16479072)	Hong S.B.... Sim W.Y.	2006	CCL2
20	Association of HLA haplotype with alopecia areata in Chinese Hans. (17062033)	Xiao F.L.... Zhang X.J.	2006	HLA-DQA1, HLA-A, HLA-DQB1
21	The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata. (16829308)	Kemp E.H.... Tazi-Ahnini R.	2006	PTPN22
22	Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata. (17117947)	Schafer N.... Betz R.C.	2006	FCRL3
23	Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata. (15815686)	Shimizu T.... Shimizu H.	2005	MIF
24	Association between alopecia areata and HLA Class I and II in Turkey. (16361713)	Aliagaoglu C.... Aktas A.	2005	HLA-A, HLA-DRB1, HLA-B
25	Interferon-gamma and neopterin in alopecia areata (16052058)	Lortkipanidze N.T.... Kamkamidze G.K.	2005	IFNG
26	Evaluation of lipid peroxidation, oxidant/antioxidant status, and serum nitric oxide levels in alopecia areata. (15917721)	Koca R.... GA1rel A.	2005	SOD1, XDH
27	Lack of association between Vitamin D receptor FokI polymorphism and alopecia areata. (15246940)	Akar A.... Gur A.R.	2004	VDR
28	Interferon-gamma in alopecia areata. (14965793)	Arca E.... TaA9tan H.B.	2004	IL2, IFNG
29	Selective expression of chemokine monokine induced by interferon-gamma in alopecia areata. (14632215)	Benoit S.... Gillitzer R.	2003	IFNG
30	Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. (12589427)	Tazi-Ahnini R.... McDonagh A.J.	2003	NOTCH4
31	Strong expression of CD40, CD54 and HLA-DR antigen and lack of evidence for direct cellular cytotoxicity are unique immunohistopathological features in alopecia areata. (12624779)	Sato-Kawamura M.... Tagami H.	2003	ICAM1, CD40
32	Therapy of alopecia areata: on the cusp and in the fu ture. (14582675)	Price V.H.	2003	IFNG
33	A natural canine homologue of alopecia areata in humans. (14632797)	Tobin D.J.... Olivry T.	2003	TCHH
34	Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction. (11841485)	Tazi-Ahnini R.... Cork M.J.	2002	IL1R1, IL1RN, IL36RN
35	HLA class II alleles in patients with alopecia areata. (11978563)	Akar A.... Gur A.R.	2002	HLA-DQB1, HLA-DRB1
36	Association analysis of IL1A and IL1B variants in alopecia areata. (11703512)	Tazi-Ahnini R.... Cork M.J.	2001	IL1B, IL1A
37	Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. (10942113)	Tazi-Ahnini R.... Cork M.J.	2000	MX1
38	Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice. (10674367)	Gilhar A.... Kalish R.S.	1999	ICAM1
39	Contribution of interleukin 1beta and KM loci to alopecia areata. (10077728)	Galbraith G.M.... Pandey J.P.	1999	IGKC
40	Thymopentin in alopecia areata (9576023)	Gruber D.M.... Huber J.C.	1998	TMPO
41	Equine alopecia areata autoantibodies target multiple hair follicle antigens and may alter hair growth. A preliminary study. (9832317)	Tobin D.J.... Olivry T.	1998	TCHH
42	Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. (9421466)	Gilhar A.... Kalish R.S.	1998	ICAM1
43	Growth factor mRNA levels in alopecia areata before and after treatment with the contact allergen diphenylcyclopropenone. (8721483)	Hoffmann R.... Happle R.	1996	ICAM1
44	An allele of the interleukin-1 receptor antagonist as a genetic severity factor in alopecia areata. (7738374)	Cork M.J.... Duff G.W.	1995	IL1R1
45	Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. (8077705)	Tarlow J.K.... Duff G.W.	1994	IL1RN
46	Response of grafts from patients with alopecia areata transplanted onto nude mice, to administration of interferon-gamma. (8095867)	Gilhar A.... Eidelman S.	1993	IFNG
47	HLA and ICAM-1 expression in alopecia areata in vivo and in vitro: the role of cytokines. (7506926)	McDonagh A.J.... Messenger A.G.	1993	ICAM1, IFNG
48	Aberrant intercellular adhesion molecule-1 (ICAM-1) expression by hair-follicle epithelial cells and endothelial leukocyte adhesion molecule-1 (ELAM-1) by vascular cells are important adhesion-molecule alterations in alopecia areata. (1708803)	Nickoloff B.J.... Griffiths C.E.	1991	ICAM1
49	Simultaneous development of insulin dependent diabetes mellitus and alopecia areata universalis. (2012115)	Taniyama M.... Sueki H.	1991	INS
50	HLA-D locus associations in alopecia areata. DRw52a m ay confer disease resistance. (1670917)	Duvic M.... Reveille J.D.	1991	HLA-DRB3

Genes related to alopecia areata according to GeneCards:

(show top 50)    (show all 82)

id	Symbol	Description	Score	GeneCards Section Context
1	AA1	Alopecia areata 1	11.1	Aliases & Descriptions
2	AA2	Alopecia areata 2	11.1	Aliases & Descriptions
3	AIRE	autoimmune regulator	11.0	Publications
4	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
5	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
6	ICAM1	intercellular adhesion molecule 1	11.0	Publications
7	IL1R1	interleukin 1 receptor, type I	11.0	Publications
8	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
9	IL1A	interleukin 1, alpha	11.0	Publications
10	IFNG	interferon, gamma	11.0	Publications
11	ULBP3	UL16 binding protein 3	11.0	Publications
12	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	11.0	Publications
13	TCHH	trichohyalin	11.0	Publications
14	IFRD2	interferon-related developmental regulator 2	11.0
15	IKZF4	IKAROS family zinc finger 4 (Eos)	11.0	Publications
16	IL36RN	interleukin 36 receptor antagonist	11.0	Publications
17	IGKC	immunoglobulin kappa constant	11.0	Publications
18	STX17	syntaxin 17	11.0	Publications
19	T	T, brachyury homolog (mouse)	11.0	Publications
20	HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	11.0	Publications
21	FCRL3	Fc receptor-like 3	11.0	Publications
22	KRT16	keratin 16	11.0	Publications
23	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
24	TNFSF13	tumor necrosis factor (ligand) superfamily, member 13	11.0	Publications
25	ICOS	inducible T-cell co-stimulator	11.0	Publications
26	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
27	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	11.0	Publications
28	NES	nestin	11.0	Publications
29	KLRK1	killer cell lectin-like receptor subfamily K, member 1	11.0	Publications
30	MC2R	melanocortin 2 receptor (adrenocorticotropic hormone)	11.0	Publications
31	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
32	IL21	interleukin 21	11.0	Publications
33	NOTCH4	notch 4	11.0	Publications
34	PRDX5	peroxiredoxin 5	11.0	Publications
35	TRAF1	TNF receptor-associated factor 1	11.0	Publications
36	C5	complement component 5	11.0	Publications
37	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
38	ERAL1	Era G-protein-like 1 (E. coli)	11.0
39	PSIP1	PC4 and SFRS1 interacting protein 1	11.0	Publications
40	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
41	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
42	TMPO	thymopoietin	11.0	Publications
43	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
44	MICA	MHC class I polypeptide-related sequence A	11.0	Publications
45	FLG	filaggrin	11.0	Publications
46	CCL4	chemokine (C-C motif) ligand 4	11.0	Publications
47	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
48	ACP1	acid phosphatase 1, soluble	11.0	Publications
49	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
50	IL16	interleukin 16	11.0	Publications

Pathways related to alopecia areata according to GeneDecks:

(show top 50)    (show all 143)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.1	CD40, HLA-DQA2, CTLA4, ICOS
2	Antigen processing and presentation20	10.0	CIITA, HLA-DQA2, HLA-C, HLA-DRB3, HLA-DRB1, HLA-DQB1
3	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.8	TNFRSF1A, CCL4, FASLG, IL2RA, IL2, GZMB
4	Immune System38	9.8	CD40, CD79A, MX1, CIITA, ULBP3, FCGR1A
5	CTL Mediated Apoptosis36	9.5	HLA-A, GZMB, HLA-B, HLA-DQB1, HLA-C, HLA-DQA1
6	Graft-versus-host disease20	9.5	IL1A, HLA-DRB3, HLA-DQA2, HLA-DQA1, HLA-C, HLA-B
7	Staphylococcus aureus infection20	9.4	HLA-DRB3, FCGR1A, IL10, ICAM1, HLA-DQA1, HLA-DQB1
8	RAR-Gamma-RXR-Alpha Degradation36	9.3	CCL5, CCL11, CCL27, CCL4, IL3, IL21
9	NFAT Signaling and Lymphocyte Interactions36	9.2	TNFSF13B, CCL11, CCL2, CCL27, CCL4, IL4
10	Regulation of eIF4 and p70S6K36	9.1	IL1A, IL2, CCL11, IL3, IL16, IL4
11	Viral myocarditis20	8.9	HLA-A, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
12	Natural killer cell mediated cytotoxicity20	8.6	GZMB, ULBP3, HLA-B, MICA, FAS, IFNG
13	IL-6 Pathway36	8.6	IL10, IL16, IL3, IL4, IL8, CCL4
14	Asthma20	8.5	TNF, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
15	Intestinal immune network for IgA production20	8.5	CD40, IL10, IL2, IL4, CCL27, ICOS
16	Toxoplasmosis20	8.4	HLA-DQB1, IFNG, CIITA, TGFB1, TNFRSF1A, TNF
17	PGC1Alpha Pathway36	8.3	CCL5, IL16, IL1A, IL1B, CCL11, CCL27
18	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.3	IL10, IL2RA, IL2, FASLG, FAS, TNF
19	Hematopoietic cell lineage20	8.3	TNF, HLA-DRB3, IL4, TPO, IL3, IL2RA
20	Tuberculosis20	8.2	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, IFNG
21	THC Differentiation Pathway36	8.2	IL2RA, IL2, IL10, IL4, IFNG, TNFRSF1A
22	Leishmaniasis20	8.2	HLA-DQA2, HLA-DQA1, IFNG, IL4, IL1B, IL1A
23	Molecular Mechanisms of Cancer36	8.2	CCL27, PSIP1, IL3, CCL11, CCL5, TNFSF13B
24	Malaria20	8.1	CCL2, TGFB1, KLRK1, IFNG, TNF, ICAM1
25	Cytokine Network36	8.0	IFNG, IL8, IL4, IL3, IL2, IL1B
26	Autoimmune thyroid disease20	7.9	HLA-C, HLA-B, HLA-A, FAS, FASLG, IL4
27	Rheumatoid arthritis20	7.9	TNF, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
28	Endothelin-1 Signaling Pathway36	7.9	CCL27, CCL5, TNFSF13, TNFSF13B, EGFR, CXCL9
29	Influenza A20	7.8	FAS, CCL2, CCL5, IFNG, ICAM1, HLA-DQA1
30	Akt Signaling36	7.6	IL10, IL16, IL2, IL21, IL2RA, IL4
31	Allograft rejection20	7.5	HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-C, HLA-B
32	ERK Signaling36	7.4	TGFB1, EGFR, PSIP1, TNFSF13B, TNFSF13, CCL5
33	Chagas disease (American trypanosomiasis)20	7.3	CCL5, IL10, IL1B, IL2, IL8, FASLG
34	Tec Kinases Signaling36	7.2	PSIP1, TGFB1, EGFR, TNFSF13B, CCL5, CCL11
35	Glucocorticoid Receptor Signaling36	7.2	TGFB1, TNFSF13B, TNFRSF1A, CCL5, IL1B, IL1A
36	Rho Family GTPases36	7.2	CXCL9, PSIP1, TGFB1, TNFSF13B, TNFSF13, CCL5
37	Type I diabetes mellitus20	7.1	INS, GZMB, HLA-C, HLA-B, HLA-A, IFNG
38	SOCS Pathway36	7.0	IL3, IL2, IL1B, IL1A, IL16, IL10
39	all-trans-Retinoic Acid Signaling in Brain36	7.0	CCL27, CCL2, CCL11, CCL5, TNF, TNFSF13
40	PEDF Induced Signaling36	7.0	TNF, IL1A, IL16, IL10, CCL27, IL1B
41	MIF Mediated Glucocorticoid Regulation36	6.9	CXCL9, TNFSF13B, TNFSF13, MIF, IL10, IL16
42	MIF Regulation of Innate Immune Cells36	6.9	MIF, IL10, IL16, IL1A, IL1B, IL2
43	STAT3 Pathway36	6.7	CXCL9, TNFSF13B, TNFSF13, TNFRSF1A, TNF, CCL5
44	TGF-Beta Pathway36	6.6	PSIP1, TGFB1, EGFR, TNFSF13B, TNFRSF1A, IL1R1
45	JAK-STAT Pathway36	6.6	PSIP1, TGFB1, EGFR, TNFSF13B, TNFRSF1A, IFNG
46	MAPK Family Pathway36	6.0	CCL27, IL10, IL16, IL1A, CCL4, IL8
47	PAK Pathway36	5.8	CXCL9, PSIP1, TGFB1, EGFR, TNFSF13B, TNFSF13
48	Antioxidant Action of Vitamin-C36	5.7	CCL4, CXCL9, CCL27, CCL2, CCL11, CCL5
49	p38 Signaling36	5.6	CCL5, CXCL9, PSIP1, TGFB1, EGFR, TNFSF13B
50	Cytokine-cytokine receptor interaction20	5.3	CCL5, IL21, IL2, IL1R1, IL1B, IL1A

Compounds related to alopecia areata according to GeneDecks:

(show top 50)    (show all 320)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.2	F8, CCL4, FASLG, IL3, FCGR1A
2	endotoxin32	9.8	CCL11, CCL4, FASLG, IL1R1, MIF, CD40
3	ionomycin32	9.7	CD40, IL3, CCL4, TNFRSF1A, CCL11
4	ascorbic acid32 18	10.5	VDR, FLG, IL1A, PRDX5, ACP1, TPO
5	pge232	9.4	IL1A, FCGR1A, CIITA, IL1R1, PSIP1, ACP1
6	sb 20358032 42	10.1	CCL11, CCL4, IL1R1, BIRC5, VDR, CCL5
7	allergens32	9.1	CD79A, CIITA, CD40, FLG, IL10, CTLA4
8	polyinosinic-polycytidylic acid32	9.0	KLRK1, HLA-B, IFNG, IL8, IL4, IL2
9	cysteine32	8.8	CD40, CDKN2A, CD79A, XDH, VDR, GZMB
10	h2o232	8.8	CD79A, XDH, CD40, PRDX5, TNFRSF1A, TPO
11	n acetylcysteine32	8.8	BIRC5, PRDX5, EGFR, CCL11, IL3, IL2RA
12	okt332	8.6	TNFRSF1A, TNF, ICAM1, FAS, IL2RA, IL2
13	gold sodium thiomalate32	8.5	TNF, HLA-DRB1, IFNG, IL8, IL2RA, IL2
14	rituximab32 34 9 9	11.5	CTLA4, TNFSF13B, F8, FASLG, IL2RA, IL2
15	polymyxin b32	8.4	IL4, IL1RN, IL1B, IL1A, IL10, IL8
16	tarc32	8.4	CXCL9, TNF, ICAM1, IFNG, CCL5, CCL11
17	groalpha32	8.4	ICAM1, CCL5, CCL11, CCL2, CCL4, IL8
18	vegf32	8.3	IL1RN, IL1R1, IL1B, IL1A, MIF, CD40
19	toxin-132	8.3	CCL2, CCL4, IL8, IL2, IL1RN, IL1B
20	oxygen32 18	9.2	CCL11, CCL4, FAS, FCGR1A, MIF, GZMB
21	ccl332	8.2	CXCL9, IL10, IL1A, TNF, ICAM1, IFNG
22	histamine32 18	9.2	CCL5, CCL11, CCL2, CCL4, IL4, IL3
23	infliximab32 9 9	10.2	FLG, CTLA4, TNFRSF1A, TNF, IFNG, FAS
24	prednisolone32 9 9	10.1	TNF, F8, IFNG, CCL11, CCL4, FAS
25	simvastatin32 34 42 9 18 9	12.9	CCL4, FASLG, IL8, IL4, IL1RN, IL1A
26	pentoxifylline32 9 9	9.9	TNF, ICAM1, IFNG, IL8, IL4, IL2RA
27	ly29400232	7.6	IL1B, IL10, GZMB, IL4, IL8, FASLG
28	pdtc32	7.5	SOD1, BIRC5, TGFB1, TNF, ICAM1, IFNG
29	gm-csf32	7.3	CCL2, IL8, IL4, IL3, IL2, IL1B
30	rantes32	7.1	CCL4, FAS, FASLG, IL4, IL3, IL2RA
31	neopterin32	7.1	IL2, IL1RN, IL1R1, IL1B, IL1A, IL10
32	herbimycin a32 42	7.9	TNFRSF1A, TNF, ICAM1, IFNG, CCL11, CCL2
33	hydrocortisone32 9 9	8.6	IL8, IL4, IL3, IL2, IL1RN, IL1R1
34	il 1032	6.5	VDR, CD40, CCL2, CCL4, IL8, IL4
35	paraffin32	6.4	NES, TGFB1, EGFR, KRT16, CD79A, BIRC5
36	arginine32	6.4	ACP1, KLRK1, NOS3, PTPN22, TMPO, TPO
37	lactate32	6.3	SOD1, PRDX5, TGFB1, TNF, HLA-B, ICAM1
38	creatinine32	6.2	SOD1, CXCL9, PRDX5, TGFB1, IL1A, INS
39	thymidine32 18	7.1	TGFB1, CTLA4, TNFSF13B, TNF, IFNG, CCL11
40	actinomycin d32	6.1	TGFB1, NOS3, IL1B, IL1A, FCGR1A, CD40
41	alanine32	6.1	SOD1, TGFB1, ACP1, CTLA4, TNFSF13B, TNFRSF1A
42	indomethacin32 9 9	8.0	CD40, CD79A, BIRC5, CCL5, CCL11, CCL4
43	tacrolimus32 34 9 9	8.8	IL4, IL3, IL2RA, IL2, IL16, IL10
44	genistein32 9 18 9	8.7	FAS, VDR, BIRC5, FASLG, IL8, IL3
45	retinoic acid32 42 18	7.5	TNFRSF1A, IL1A, MIF, FLG, GZMB, CD40
46	cyclosporin a32 42	6.3	IL4, VDR, IL3, IL2RA, IL2, IL1RN
47	tyrosine32	4.8	NES, CXCL9, PSIP1, ACP1, EGFR, CTLA4
48	cycloheximide32	4.8	TGFB1, ACP1, EGFR, TNFRSF1A, IL1RN, IL1R1
49	nitric oxide32 9 18 9	7.6	IFNG, CCL5, CCL11, CCL2, CCL4, FAS
50	serine32	4.3	TGFB1, ACP1, EGFR, KRT16, NOS3, CTLA4

Cellular components related to alopecia areata according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	10.1	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
2	clathrin-coated endocytic vesicle membrane	GO:030669	10.1	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, FCGR1B
3	trans-Golgi network membrane	GO:032588	10.0	HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, HLA-DRB3
4	MHC class I protein complex	GO:042612	9.9	HLA-C, HLA-B, HLA-A, MICA, ULBP3
5	transport vesicle membrane	GO:030658	9.9	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
6	Golgi membrane	GO:000139	9.9	NOTCH4, HLA-DRB3, HLA-DQB1, HLA-DQA2, HLA-DQA1
7	early endosome membrane	GO:031901	9.9	FCGR1A, FCGR1B, HLA-A, HLA-B, HLA-C
8	endocytic vesicle membrane	GO:030666	9.9	NOS3, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
9	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.7	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-C
10	ER to Golgi transport vesicle membrane	GO:012507	9.7	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-C
11	cell surface	GO:009986	8.7	TGFB1, NOTCH4, TNFRSF1A, TNF, TPO, IL1R1
12	external side of plasma membrane	GO:009897	8.5	HLA-DRB1, HLA-DRB3, TNF, CTLA4, CXCL9, ICOS
13	integral to plasma membrane	GO:005887	8.1	HLA-DQA2, HLA-DRB1, HLA-DRB3, TPO, TNF, TNFRSF1A
14	plasma membrane	GO:005886	5.6	TPO, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
15	extracellular region	GO:005576	5.4	CCL11, CCL5, IGKC, IFNG, F8, ICOS
16	extracellular space	GO:005615	3.9	C5, CCL2, CCL11, CCL5, IFNG, F8

Biological processes related to alopecia areata according to GeneDecks:

(show top 50)    (show all 70)

id	Name	GO ID	Score	Top Affiliating Genes
1	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.4	HLA-DQB1, HLA-DRB1, HLA-DRB3
2	chronic inflammatory response to antigenic stimulus	GO:002439	10.3	IL1RN, IL1B
3	humoral immune response mediated by circulating immunoglobulin	GO:002455	10.3	HLA-DRB3, HLA-DRB1, HLA-DQB1
4	detection of bacterium	GO:016045	10.2	HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
5	T cell costimulation	GO:031295	10.2	CTLA4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
6	T cell receptor signaling pathway	GO:050852	10.1	PTPN22, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
7	positive regulation of MHC class II biosynthetic process	GO:045348	10.1	CIITA, IL10, IL4, IFNG
8	response to amino acid stimulus	GO:043200	10.1	CCL2, ICAM1, TNFRSF1A, NOS3
9	positive regulation of isotype switching to IgG isotypes	GO:048304	10.0	IFNG, IL4, IL2, CD40
10	positive regulation vascular endothelial growth factor production	GO:010575	9.9	C5, TGFB1, IL1B, IL1A
11	positive regulation of tyrosine phosphorylation of Stat1 protein	GO:042511	9.9	CD40, IFNG, TNFRSF1A
12	regulation of immune response	GO:050776	9.8	HLA-C, HLA-B, HLA-A, ICAM1, IGKC, IL4
13	cellular calcium ion homeostasis	GO:006874	9.8	C5, TGFB1, CCL5, CCL11, CCL2, CD40
14	negative regulation of T cell proliferation	GO:042130	9.8	IL10, HLA-DRB1, HLA-DRB3, TGFB1
15	positive regulation of T cell proliferation	GO:042102	9.7	IFNG, CCL5, IL4, IL21, IL1B
16	chemotaxis	GO:006935	9.7	C5, CXCL9, CCL5, CCL11, CCL2, CCL27
17	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.7	TNF, IFNG, IL1B
18	positive regulation of angiogenesis	GO:045766	9.7	C5, NOS3, TNFRSF1A, CCL5, CCL11, IL1B
19	cellular response to lipopolysaccharide	GO:071222	9.7	ICAM1, IFNG, CCL2, IL8, IL10
20	interferon-gamma-mediated signaling pathway	GO:060333	9.7	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-C
21	cell surface receptor signaling pathway	GO:007166	9.5	C5, EGFR, IFNG, CCL2, IL2RA, IL1R1
22	virus-host interaction	GO:019048	9.4	PSIP1, TGFB1, TNFRSF1A, HLA-C, HLA-B, HLA-A
23	positive regulation of chemokine biosynthetic process	GO:045080	9.4	TNF, IFNG, IL4, IL1B
24	positive regulation of fever generation	GO:031622	9.4	TNF, CCL5, IL1B
25	response to ethanol	GO:045471	9.3	SOD1, NOS3, TNFRSF1A, ICAM1, CCL2, IL4
26	response to heat	GO:009408	9.2	SOD1, PSIP1, NOS3, CCL2, IL1B, MICA
27	aging	GO:007568	9.2	TGFB1, NOS3, CCL5, CCL2, FAS, IL1B
28	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.2	TNFRSF1A, TNF, TRAF1, FASLG, IL1B, IL1A
29	protein kinase B signaling cascade	GO:043491	9.1	TGFB1, TNF, CCL5, CCL2, IL1B
30	response to activity	GO:014823	9.1	IL10, CCL2, CCL5, TNF
31	cellular response to organic cyclic compound	GO:071407	9.1	TGFB1, TNF, CCL5, CCL2, IL1B
32	lipopolysaccharide-mediated signaling pathway	GO:031663	8.9	TGFB1, NOS3, TNF, CCL5, CCL2, IL1B
33	positive regulation of cytokine secretion	GO:050715	8.9	TNF, IL1A, IL10, INS, MIF
34	induction of apoptosis	GO:006917	8.8	C5, TGFB1, TNF, FAS, FASLG, CDKN2A
35	response to glucocorticoid stimulus	GO:051384	8.8	TNF, CCL5, CCL2, FAS, IL1RN, IL1B
36	cytokine-mediated signaling pathway	GO:019221	8.8	HLA-DQA2, HLA-DQA1, HLA-C, HLA-B, HLA-A, ICAM1
37	response to hypoxia	GO:001666	8.7	TGFB1, NOS3, TNFRSF1A, TNF, CCL2, FAS
38	positive regulation of mitosis	GO:045840	8.4	TNF, IL1B, IL1A, INS
39	positive regulation of nitric oxide biosynthetic process	GO:045429	8.4	EGFR, TNF, ICAM1, IFNG, IL1B, INS
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.4	TGFB1, TNF, TRAF1, ICAM1, IL1B, INS
41	positive regulation of apoptotic process	GO:043065	8.2	SOD1, NOS3, CTLA4, TNF, FAS, FASLG
42	cell-cell signaling	GO:007267	8.1	CXCL9, CCL5, CCL27, CCL4, FASLG, IL3
43	signal transduction	GO:007165	8.1	CCL2, CCL11, HLA-DRB3, TRAF1, TNFSF13, TNFSF13B
44	positive regulation of cell proliferation	GO:008284	8.0	TGFB1, EGFR, TNFSF13B, TNFSF13, FASLG, IL3
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	IFNG, AIRE, TNF, TNFRSF1A, TGFB1, PSIP1
46	response to drug	GO:042493	7.8	NES, SOD1, TGFB1, NOS3, TNF, ICAM1
47	MAPK cascade	GO:000165	7.8	TGFB1, EGFR, TNF, CCL5, CCL2, IL1B
48	inflammatory response	GO:006954	7.6	CCL5, TNF, TNFRSF1A, TGFB1, PRDX5, CXCL9
49	anti-apoptosis	GO:006916	7.6	SOD1, NOS3, TNF, CCL2, FAS, IL2
50	immune response	GO:006955	7.0	CXCL9, CTLA4, IL8, IL4, IL3, IL2RA

Molecular functions related to alopecia areata according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	10.1	HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1
2	CCR5 chemokine receptor binding	GO:031730	10.1	CCL4, CCL5, NES
3	MHC class I receptor activity	GO:032393	10.0	HLA-C, HLA-B, HLA-A, ULBP3
4	interleukin-1 receptor binding	GO:005149	10.0	IL1A, IL1B, IL1RN
5	chemokine activity	GO:008009	9.5	C5, CXCL9, CCL5, CCL11, CCL2, CCL27
6	receptor binding	GO:005102	9.3	C5, PRDX5, TNFSF13B, TNFSF13, HLA-B, HLA-A
7	tumor necrosis factor receptor binding	GO:005164	9.2	TNFSF13B, TNFSF13, TNF, FASLG
8	cytokine activity	GO:005125	7.4	MIF, CXCL9, TNFSF13B, TNFSF13, TNF, IFNG
9	protein binding	GO:005515	3.9	TMPO, TNFSF13B, TNFRSF1A, TNF, TRAF1, HLA-DRB3