AA
MCID: ALP009
MIFTS: 64

Alopecia Areata (AA) malady

Genetic diseases, Rare diseases, Skin diseases, Immune diseases categories
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Summaries for Alopecia Areata

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8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Alopecia areata is an autoimmune disease in which the immune system mistakenly attacks the hair follicles. this can lead to hair loss on the scalp and elsewhere on the body. in most cases, hair falls out in small, round patches on the scalp. although uncommon, hair loss can be more extensive in some people. this condition can progress to cause total loss of hair on the head (alopecia totalis) or complete loss of hair on the head, face, and body (alopecia universalis). while there is neither a cure for nor drugs approved for treatment, some people find that medications approved for other purposes can help their hair grow back. last updated: 5/9/2011

MalaCards: Alopecia Areata, also known as circumscribed alopecia, is related to alopecia and vitiligo. An important gene associated with Alopecia Areata is AIRE (autoimmune regulator), and among its related pathways are Primary immunodeficiency and Downstream signaling in naive CD8+ T cells. The compounds 2-chloroethyl ethyl sulfide and pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Disease Ontology:8 A hypersensitivity reaction type ii disease resulting in the loss of hair on the scalp and elsewhere on the body initally causing bald spots.

Wikipedia:65 Alopecia areata (AA) is a condition in which hair is lost from some or all areas of the body, usually... more...

Description from OMIM:47 104000,610753

Aliases & Classifications for Alopecia Areata

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8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 62UMLS, 47OMIM, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases, Immune diseases


Aliases & Descriptions:

alopecia areata 8 43 20 22 10 45 62
circumscribed alopecia 8
alopecia circumscripta 43
alopecia cicatrisata 43
cazenave's vitiligo 43
jonston's alopecia 43
marginal alopecia 43
celsus' vitiligo 43
diffuse alopecia 43
alopecia totalis 62
patchy alopecia 43
alopecia celsi 43
aa 43


External Ids:

Disease Ontology8 DOID:986
ICD9CM27 704.01
ICD1025 L63

Related Diseases for Alopecia Areata

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17GeneCards, 18GeneDecks
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Diseases in the Alopecia Areata family:

Alopecia Areata 2 Alopecia Areata 1

Diseases related to Alopecia Areata via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 333)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia32.5AIRE
2vitiligo31.2CIITA, AIRE
3thyroiditis30.9CIITA
4psoriasis30.9IL1A, IL1R1, IFNG, GZMB, ICAM1, CIITA
5dermatitis30.9ICAM1, IFNG, IL1A, GZMB
6lichen planus30.9GZMB, ICAM1
7atopic dermatitis30.7ICAM1, IFNG, IL1A
8candidiasis30.6IFNG, AIRE
9myasthenia gravis30.6AIRE, IFNG
10diabetes mellitus30.5IL1R1, ICAM1, AIRE
11thymoma30.5AIRE, IL1R1, IL1A
12aplastic anemia30.3IFNG, GZMB
13hypothyroidism30.3IL1A, AIRE
14oral lichen planus30.3ICAM1, IL1A
15skin disease30.2IL1A, GZMB
16type 1 diabetes mellitus30.2IL1R1, CIITA, AIRE
17celiac disease30.2CIITA, GZMB
18hepatitis b30.2IFNG, CIITA, GZMB
19lymphopenia30.2IFNG, CIITA, IL1RN
20autoimmune thyroiditis30.2CIITA, IFNG, ICAM1, AIRE
21arthritis30.2ICAM1, IL1R1, IL1RN, IFNG, GZMB, CIITA
22uveitis30.1ICAM1, IL1R1, IL1A, IFNG
23rheumatic disease30.1IL1RN, IL1R1
24rheumatoid arthritis30.1ICAM1, FCRL3, GZMB, IL1A, IL1RN, IL1R1
25leukemia30.1IL1R1, IFNG, GZMB, IL1A, ICAM1
26sarcoidosis30.0ICAM1, IFNG, GZMB, IL1RN, IL1A
27influenza30.0IFNG, CIITA, GZMB
28ulcerative colitis30.0IFNG, IL1R1, IL1RN, IL1A, ICAM1, GZMB
29myositis30.0ICAM1, IL1A, CIITA, GZMB, IL1RN
30systemic lupus erythematosus30.0IL1RN, ICAM1, FCRL3, IFNG, CIITA, IL1R1
31asthma30.0GZMB, IFNG, ICAM1, CIITA
32septic shock29.9IL1RN, CIITA, IL1A, IL1R1
33graves' disease29.9FCRL3, AIRE, IL1RN, IFNG, ICAM1, CIITA
34sepsis29.9IL1R1, CIITA, IL1A, IL1RN
35periodontal disease29.9ICAM1
36periodontitis29.9IL1A
37inflammatory bowel disease29.9IL1RN, CIITA, ICAM1, IFNG, IL1R1
38malaria29.9IFNG, ICAM1
39schnitzler syndrome29.8IL1R1, IL1RN
40chorioamnionitis29.8IL1RN, IL1R1
41ankylosing spondylitis29.8IL1R1, IL1RN
42tuberculosis29.8GZMB, IFNG, CIITA
43relapsing-remitting multiple sclerosis29.8IL1RN, ICAM1, IFNG
44melanoma29.7ICAM1, IFNG, CIITA, IL1A, GZMB
45multiple sclerosis29.6CIITA, ICAM1, IL1RN, IL1R1, IFNG
46amyloidosis10.9
47alopecia universalis10.8
48alopecia totalis10.6
49diffuse alopecia areata10.6
50trichotillomania10.5

Graphical network of the top 20 diseases related to Alopecia Areata:



Diseases related to alopecia areata

Symptoms for Alopecia Areata

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47OMIM
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Clinical features from OMIM:

104000,610753

Drugs & Therapeutics for Alopecia Areata

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Alopecia Areata

Search NIH Clinical Center for Alopecia Areata

Genetic Tests for Alopecia Areata

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20GeneTests, 22GTR
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Genetic tests related to Alopecia Areata:

id Genetic test Affiliating Genes
1 Alopecia Areata20 22

Anatomical Context for Alopecia Areata

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33MalaCards
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MalaCards organs/tissues related to Alopecia Areata:

33
Skin, T cells, Thyroid, Testes, Endothelial, Pituitary, Thymus, Heart, Monocytes, Nk cells, Bone

Animal Models for Alopecia Areata or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Alopecia Areata:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.6AIRE, CIITA, ICAM1, IFNG, IL1R1
2MP:00020068.3AIRE, ICAM1, IFNG, IL1R1, IL1A, GZMB
3MP:00107717.7ICAM1, IFNG, IL36RN, IL1R1, IL1RN
4MP:00053847.7AIRE, ICAM1, IFNG, IL1R1, IL1RN, GZMB
5MP:00053787.5IL1RN, IL1R1, IL36RN, IFNG, ICAM1, AIRE
6MP:00053857.4ICAM1, IFNG, IL36RN, IL1R1, IL1RN, IL1A
7MP:00107687.3AIRE, ICAM1, IFNG, IL36RN, IL1R1, IL1RN
8MP:00053976.5GZMB, AIRE, CIITA, ICAM1, IFNG, IL36RN
9MP:00053876.5AIRE, CIITA, ICAM1, IFNG, IL36RN, IL1R1
10MP:00053766.5AIRE, CIITA, ICAM1, IFNG, IL36RN, IL1R1

Publications for Alopecia Areata

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52PubMed
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Articles related to Alopecia Areata:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Pulse methylprednisolone therapy for the treatment of extensive alopecia areata. (23336179)
2014
2
Antidepressant effects of citalopram on treatment of alopecia areata in patients with major depressive disorder. (23339335)
2014
3
Genetic analysis of interleukin-1 receptor antagonist and interleukin-1I^ single-nucleotide polymorphisms C-511T and C+3953T in alopecia areata: susceptibility and severity association. (23584371)
2013
4
Alopecia areata associated with Herpes zoster. (23682830)
2013
5
Therapy for alopecia areata in mice using parathyroid hormone agonists and antagonists, linked to a collagen-binding domain. (24326563)
2013
6
Alopecia areata - Vitiligo overlap syndrome: an emerging clinical variant. (23760330)
2013
7
Summary of the Preceding Three Alopecia Areata Research Summits: What's Past Is Prologue. (24326556)
2013
8
Growth hormone deficiency in a young patient with alopecia areata. (24326559)
2013
9
Universal protocol for alopecia areata clinical studies. (24326554)
2013
10
Early stage alopecia areata is associated with inflammation in the upper dermis and damage to the hair follicle infundibulum. (23808570)
2013
11
Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in alopecia areata patients. (22591107)
2013
12
Alopecia areata in a patient receiving infliximab. (23760327)
2013
13
Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata. (24194967)
2013
14
Alopecia areata during treatment with adalimumab: therapy with an alternative TNF-alpha inhibitor is possible. (23279686)
2013
15
Practice gaps. Alopecia areata and comorbid conditions. (23699633)
2013
16
Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship? (23329992)
2012
17
General practitioners' knowledge and practices related to alopecia areata in Qassim region, Saudi Arabia. (22415332)
2012
18
Association between scalp psoriasis and alopecia areata. (22535354)
2012
19
Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. (22930385)
2012
20
Amelanocytic anhidrotic alopecia areata-like phenotype after allogeneic hematopoietic cell transplant. (22911189)
2012
21
RenbAPk phenomenon in a patient with alopecia areata universalis. (22911207)
2012
22
No filaggrin gene mutation in a patient with a combination of atopic dermatitis, alopecia areata and food allergy. (23174665)
2012
23
Triggering role of stressful life events in patients with alopecia areata. (23317485)
2012
24
Investigative guidelines for alopecia areata. (21689240)
2011
25
Oral erosive lichen planus and alopecia areata with Good's syndrome (thymoma with hypogammaglobulinemia). (21282092)
2011
26
Dermatologic therapy: Alopecia areata update. (21689237)
2011
27
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (20596022)
2010
28
Bimatoprost in the treatment of eyelash universalis alopecia areata. (21712909)
2010
29
Serum concentrations of interferon-gamma (IFN-g) in patients with alopecia areata: correlation with clinical type and duration of the disease. (21246917)
2010
30
Management of alopecia areata. (20656774)
2010
31
Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity. (20535136)
2010
32
Is Helicobacter pylori infection associated with alopecia areata? (19250167)
2009
33
Treatment of alopecia areata in children. (19685659)
2009
34
Alopecia areata is not associated with Helicobacter pylori. (20049262)
2009
35
Development of alopecia areata is associated with higher central and peripheral hypothalamic-pituitary-adrenal tone in the skin graft induced C3H/HeJ mouse model. (19020552)
2009
36
History of atopy or autoimmunity increases risk of alopecia areata. (19608295)
2009
37
Lack of efficacy of topical imiquimod in the treatment of patchy alopecia areata. (18986369)
2008
38
Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample. (18986440)
2008
39
Poor long term outcome of severe alopecia areata in children treated with high dose pulse corticosteroid therapy. (18279461)
2008
40
Alopecia areata and autoimmunity. (18833068)
2008
41
Susceptible and protective endothelial nitric oxide synthase gene polymorphism in alopecia areata in the Kuwaiti population. (18608176)
2008
42
Serum selenium level in Iranian patients with alopecia areata. (18452532)
2008
43
In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101. (15953089)
2005
44
Extensive alopecia areata treated with betamethasone oral mini-pulse therapy: an open uncontrolled study. (17642661)
2004
45
Clinical evolution of alopecia areata with a male androgenetic alopecia pattern to sisaipho. (10694313)
2000
46
Equine alopecia areata autoantibodies target multiple hair follicle antigens and may alter hair growth. A preliminary study. (9832317)
1998
47
Scalp metastases mimicking alopecia areata. First case report of placental site trophoblastic tumor presenting as cutaneous metastasis. (9598016)
1998
48
Cytokines in alopecia areata: contrasting cytokine profiles in localized form and extensive form (alopecia universalis). (8982401)
1996
49
Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice. (1536782)
1992
50
Natural killer cell and cytotoxic/suppressor T cell deficiency in peripheral blood in subjects with alopecia areata. (3250436)
1988

Variations for Alopecia Areata

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Expression for genes affiliated with Alopecia Areata

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alopecia Areata

Search GEO for disease gene expression data for Alopecia Areata.

Pathways for genes affiliated with Alopecia Areata

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 54R&D Systems, 60Thomson Reuters, 53QIAGEN, 5Cell Signaling Technology, 55Reactome
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Pathways related to Alopecia Areata according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CIITA, AIRE
2
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.7GZMB, IFNG
3
Show member pathways
9.7IFNG, GZMB
49.6IFNG, ICAM1
59.6ICAM1, IFNG
69.6ICAM1, IFNG
79.6ICAM1, IFNG
89.5IL1A, IFNG
99.5IL1A, IFNG
109.5IL1A, IFNG
11
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.4IL1RN, IFNG
12
Show member pathways
9.4GZMB, IL1R1, IFNG
13
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.4GZMB, IL1R1, IFNG
14
Show member pathways
Immune response CD16 signaling in NK cells60
9.3ICAM1, IFNG, GZMB
159.2CIITA, ICAM1, IFNG
16
Show member pathways
9.2IL1A, IL1R1, IFNG
17
Show member pathways
9.2IL1A, IL1R1, IFNG
189.2IL1A, IL1R1, IFNG
19
Show member pathways
Immune response MIF in innate immunity response60
9.2IFNG, IL1R1, IL1A
20
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2IFNG, IL1R1, IL1A
219.2IFNG, IL1R1, IL1A
229.1IL1A, IFNG, CIITA
23
Show member pathways
9.1CIITA, IFNG, IL1A
249.1IL1A, IFNG, ICAM1
25
Show member pathways
9.0IL1A, IL1RN, IL1R1
26
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.0IL1A, IL1RN, IL1R1
278.7ICAM1, IFNG, IL1R1, IL1A
28
Show member pathways
8.7CIITA, ICAM1, IFNG, IL1A
29
Show member pathways
8.4CIITA, ICAM1, IFNG, IL1A, GZMB
30
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.2IL36RN, IL1R1, IL1RN, IL1A
31
Show member pathways
7.7IL1A, IL1RN, IL1R1, IFNG, ICAM1, CIITA

Compounds for genes affiliated with Alopecia Areata

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Sources:
45Novoseek, 61Tocris Bioscience, 11DrugBank, 29IUPHAR, 51PharmGKB, 3BitterDB, 24HMDB
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Compounds related to Alopecia Areata according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idCompoundScoreTop Affiliating Genes
12-chloroethyl ethyl sulfide459.7IL1A, IL1RN
2pirfenidone45 6110.5IFNG, IL1R1, IL1A
3minocycline45 1110.5CIITA, ICAM1, IL1A
4polyinosinic-polycytidylic acid459.4IL1A, CIITA, IFNG
5cuprophan459.4ICAM1, IL1R1, IL1RN
6amphotericin b459.4IL1RN, IFNG, IL1R1
7gm-csf45 2910.4IFNG, ICAM1, IL1A
8adalimumab45 51 1111.4IL1RN, IFNG, IL1R1
9cellulose triacetate459.4IL1RN, IL1A
10peptidoglycan45 2910.4IL1RN, IL1R1, CIITA
11etanercept45 51 1111.4IFNG, IL1RN, IL1R1
12tarc459.3IL1A, IFNG, ICAM1
13infliximab45 51 1111.3IFNG, IL1R1, IL1RN
14pdtc459.2IFNG, IL1A, ICAM1
15allergens459.2CIITA, IFNG, IL1RN
16thalidomide45 51 61 1112.2IL1R1, IL1A, IFNG
17ccl345 2910.1IL1A, IL1R1, ICAM1, IFNG
18prednisolone45 29 1111.1IL1RN, GZMB, IL1R1, IFNG
19chloroquine45 3 51 29 1113.0CIITA, IL1R1, IL1RN
20rapamycin459.0IFNG, GZMB, IL1A, IL1R1
21sodium dodecylsulfate459.0IL1A, IL1R1, CIITA, IL1RN
22sulfasalazine29 45 51 1112.0IL1R1, IL1RN, IL1A, ICAM1
23corticosterone45 61 2411.0IL1RN, IL1A, IL1R1
24polyethylene glycol459.0IL1A, IL1RN, ICAM1, IL1R1
25gold sodium thiomalate459.0IFNG, IL1R1, IL1RN, IL1A
26il 10458.9IL1RN, IL1R1, IL1A, IFNG
27polymyxin b458.9IL1A, IFNG, IL1RN, ICAM1
28hydrocortisone45 3 61 1111.9IL1A, IFNG, IL1R1, IL1RN
29ascorbic acid45 249.9IL1A, IL1RN, ICAM1, IL1R1
30indomethacin45 29 61 1111.8IFNG, IL1A, IL1RN, IL1R1
31actinomycin d458.8IFNG, IL1R1, CIITA, ICAM1, IL1A
32ribonucleic acid458.7CIITA, IL1RN, IL1A, GZMB, IL1R1
33hyaluronic acid45 249.7ICAM1, IL1R1, IL1RN, IL1A, GZMB
34ivig458.7IL1R1, IFNG, GZMB, IL1RN, IL1A
35pentoxifylline45 119.6ICAM1, IL1RN, IL1A, IFNG, IL1R1
36simvastatin45 51 61 29 24 1113.5CIITA, IL1A, IL1RN, IFNG, ICAM1
37sb 20358045 619.3IL1RN, AIRE, ICAM1, IFNG, IL1R1, IL1A
38neopterin458.3IL1A, IL1RN, IFNG, IL1R1, GZMB, ICAM1
39tyrosine458.2IL1RN, ICAM1, CIITA, GZMB, IL1R1, AIRE
40serine458.2IL1RN, AIRE, CIITA, GZMB, IL1R1, IL1A
41endotoxin458.2IL1A, ICAM1, CIITA, IFNG, IL1R1, IL1RN
42vegf458.2IL1A, ICAM1, IL1RN, IL1R1, IFNG, GZMB
43pge2458.2IL1R1, IL1A, IL1RN, ICAM1, IFNG, CIITA
44cycloheximide458.2IL1A, CIITA, ICAM1, IFNG, IL1R1, IL1RN
45retinoic acid45 249.1GZMB, IL1RN, IL1A, ICAM1, IL1R1, IFNG
46oxygen45 249.1GZMB, CIITA, IL1RN, IL1R1, ICAM1
47rantes457.9ICAM1, IL1R1, IL1RN, IL1A, GZMB, IFNG
48cyclosporin a45 29 619.9GZMB, IL1A, IL1RN, IFNG, ICAM1, CIITA
49dexamethasone45 51 29 1110.9GZMB, IFNG, IL1R1, ICAM1, IL1RN, IL1A
50nitric oxide45 24 119.9CIITA, IL1A, IL1RN, IL1R1, IFNG, ICAM1

GO Terms for genes affiliated with Alopecia Areata

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16Gene Ontology
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Cellular components related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immunological synapseGO:0017729.7GZMB, ICAM1
2extracellular spaceGO:0056157.3IL1A, IL1RN, IL36RN, IFNG, ICAM1

Biological processes related to Alopecia Areata according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.8CIITA, IFNG
2humoral immune responseGO:0069599.7IFNG, AIRE
3response to copper ionGO:0466889.6IL1A, ICAM1
4fever generationGO:0016609.5IL1A, IL1RN
5positive regulation of nitric oxide biosynthetic processGO:0454299.5IFNG, ICAM1
6interferon-gamma-mediated signaling pathwayGO:0603339.4IFNG, ICAM1, CIITA
7negative regulation of cytokine-mediated signaling pathwayGO:0019609.1IL1RN, IL36RN
8cytokine-mediated signaling pathwayGO:0192218.9CIITA, ICAM1, IFNG, IL1A
9positive regulation of transcription from RNA polymerase II promoterGO:0459448.8AIRE, CIITA, IFNG, IL1A
10response to drugGO:0424938.7IL1RN, IFNG, ICAM1
11immune responseGO:0069558.6IL1A, IL1RN, IL1R1, CIITA, AIRE

Molecular functions related to Alopecia Areata according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor antagonist activityGO:0051528.7IL1RN, IL36RN
2cytokine activityGO:0051258.7IL1A, IL36RN, IFNG
3interleukin-1 receptor bindingGO:0051498.4IL1A, IL1RN, IL36RN

Products for genes affiliated with Alopecia Areata

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  • Antibodies
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Sources for Alopecia Areata

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet