AU
MCID: ALP001
MIFTS: 66

Alopecia Universalis (AU) malady

Skin diseases category

Summaries for Alopecia Universalis

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Alopecia universalis is an uncommon form of alopecia areata. alopecia areata is hair loss of unknown cause, characterized by round patches of complete baldness. alopecia universalis, which presents itself as the loss of hair over the entire scalp and body, is an autoimmune disease, in which the immune system mistakenly attacks the hair follicles. while there is neither a cure for alopecia areata nor drugs approved for its treatment, some people find that medications approved for other purposes can help hair grow back, at least temporarily. since the hair follicles of individuals with alopecia universalis remain alive, hair regrowth may occur even without treatment and even after many years.  last updated: 5/8/2012

MalaCards: Alopecia Universalis, also known as alopecia universalis congenita, is related to alopecia and alopecia areata, and has symptoms including alopecia, decreased body hair/axillar/pubic hairlessness and absent/decreased/thin eyebrows. An important gene associated with Alopecia Universalis is HR (hair growth associated), and among its related pathways are Leishmaniasis and Immune response MIF-mediated glucocorticoid regulation. The compounds 3beta-hydroxy-delta5-steroid and cortrosyn have been mentioned in the context of this disorder. Affiliated tissues include skin, pituitary and thyroid, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Wikipedia:63 Alopecia universalis or alopecia areata universalis is a medical condition involving rapid loss of all... more...

Description from OMIM:46 203655,104000,610753

Aliases & Classifications for Alopecia Universalis

About this section
Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 20GeneTests, 22GTR, 46OMIM, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
alopecia universalis:
Prevalence: 1-5/10000


Aliases & Descriptions:

alopecia universalis 8 9 42 20 22 46 48 60
alopecia universalis congenita 8 42 22 60
loss of all hair on the body 42
alopecia areata universalis 42
generalized atrichia 42
au 42


External Ids:

Disease Ontology8 DOID:0050634
MESH via Orphanet35 C537055
ICD10 via Orphanet26 L63.1
SNOMED-CT via Orphanet57 86166000
UMLS via Orphanet61 C0263505
ICD1025 L63.1

Related Diseases for Alopecia Universalis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alopecia Universalis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia31.6HR, AIRE
2alopecia areata30.9AIRE, IFNG
3vitiligo30.7AIRE, POMC
4hepatitis30.7AIRE
5hepatitis c30.7IFNG
6diabetes mellitus30.6TNF, AIRE, POMC, INS
7thyroiditis30.5POMC
8autoimmune thyroiditis30.4CYP21A2, AIRE, IFNG
9hypothyroidism30.4INS, POMC, AIRE
10down syndrome30.3AIRE
11ulcerative colitis30.1TNF
12candidiasis30.1AIRE, IFNG
13hypogonadism30.1INS, POMC
14graves' disease30.1IFNG, AIRE, CYP21A2
15rheumatoid arthritis30.1TNF, IFNG
16arthritis30.1POMC, TNF, IFNG
17schimke immunoosseous dysplasia29.7CYP21A2, AIRE
18cholera29.7POMC, INS
19polycystic ovary syndrome29.7CYP21A2, INS
20alopecia universalis onychodystrophy vitiligo10.4
21hepatitis a10.3
22cafe au lait spots, multiple10.3
23atopic dermatitis10.3
24type 1 diabetes mellitus10.3
25pernicious anemia10.3
26acute leukemia10.3
27dermatitis10.3
28leukemia10.3
29lymphoblastic leukemia10.3
30neurofibromatosis10.3
31watson syndrome10.3
32crohn's disease10.2
33lichen planus10.2
34psoriasis10.2
35total hypotrichosis, mari type10.2
36satoyoshi syndrome10.2
37mccune albright syndrome10.2
38legius syndrome10.1
39neurofibromatosis type 610.1
40bullous pemphigoid10.1
41ichthyosis vulgaris10.1
42porphyria cutanea tarda10.1
43systemic lupus erythematosus10.1
44common variable immunodeficiency10.1
45factor viii deficiency10.1
46pityriasis rubra pilaris10.1
47sclerosing cholangitis10.1
48amyloidosis10.1
49cataract10.1
50cholangitis10.1

Graphical network of the top 20 diseases related to Alopecia Universalis:



Diseases related to alopecia universalis

Clinical Features for Alopecia Universalis

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

203655,104000,610753

Clinical synopsis from OMIM:

104000

Symptoms:

48
  • alopecia
  • decreased body hair/axillar/pubic hairlessness
  • absent/decreased/thin eyebrows
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • absent/decreased lashes
  • autosomal recessive inheritance

Drugs & Therapeutics for Alopecia Universalis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Alopecia Universalis

Drug clinical trials:

Search ClinicalTrials for Alopecia Universalis

Search NIH Clinical Center for Alopecia Universalis

Search CenterWatch for Alopecia Universalis

Genetic Tests for Alopecia Universalis

About this section
Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Alopecia Universalis:

id Genetic test Affiliating Genes
1 Alopecia Universalis20 22 HR
2 Alopecia Universalis Congenita22

Anatomical Context for Alopecia Universalis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Alopecia Universalis:

32
Skin, Pituitary, Thyroid, Liver, Bone, Bone marrow, Monocytes, T cells

Animal Models for Alopecia Universalis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Alopecia Universalis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IFNG, TNF, AIRE, POMC, HR
2MP:00053677.9IFNG, FAIM2, POMC, INS, HR
3MP:00053817.8HR, INS, AIRE, TNF, IFNG
4MP:00030127.8IFNG, TNF, AIRE, POMC, INS
5MP:00053707.7HR, INS, POMC, AIRE, TNF, IFNG
6MP:00053797.7IFNG, TNF, AIRE, POMC, INS, HR
7MP:00107717.6IFNG, TNF, LIPH, POMC, INS, HR
8MP:00053917.6IFNG, TNF, AIRE, INS, HR
9MP:00053977.4IFNG, TNF, HLA-DOA, AIRE, POMC, INS
10MP:00053877.3IFNG, TNF, HLA-DOA, AIRE, POMC, INS
11MP:00053867.1IFNG, TNF, FAIM2, AIRE, POMC, INS
12MP:00036317.1IFNG, TNF, FAIM2, AIRE, POMC, INS
13MP:00053766.9HR, INS, POMC, AIRE, FAIM2, TNF

Publications for Alopecia Universalis

About this section
Sources:
50PubMed
See all sources

Articles related to Alopecia Universalis:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Multicentric calcified trichilemmal cysts with alopecia universalis affecting siblings. (23254735)
2013
2
Autoimmune polyglandular syndrome type 2, alopecia universalis and Crohn's disease. (22677116)
2013
3
RenbAPk phenomenon in a patient with alopecia areata universalis. (22911207)
2012
4
RenbAPk phenomenon in a patient with alopecia areata universalis and psoriasis. (22150402)
2012
5
Clinical characteristics and prognostic factors in early-onset alopecia totalis and alopecia universalis. (22787378)
2012
6
A case of alopecia universalis with agminated lentiginosis and multiple cafAc-au-lait macules: a synchronous coincidence? (22182389)
2012
7
Bimatoprost in the treatment of eyelash universalis alopecia areata. (21712909)
2010
8
Latanoprost in the treatment of eyelash alopecia in alopecia areata universalis. (20028444)
2010
9
Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis. (18614380)
2009
10
Alopecia areata universalis after phenobarbital-induced anti-convulsant hypersensitivity syndrome. (19811415)
2009
11
Alopecia areata universalis elicited during treatment with adalimumab. (18230980)
2008
12
Alopecia areata universalis and acute lymphoblastic leukemia. (17616971)
2007
13
Alopecia universalis treated with bone morphogenetic protein? (16403121)
2006
14
Alopecia universalis in Down syndrome: response to therapy. (17179625)
2006
15
The use of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis. (17010743)
2006
16
Infant alopecia universalis: role of topical PUVA (psoralen ultraviolet A) radiation. (16409283)
2005
17
Alopecia areata universalis and disseminated mollusca contagiosa in atopic dermatitis. Hair re-growth during treatment with interferon gamma--therapeutic effect or coincidence?]. (15892847)
2005
18
Alopecia congenita universalis, microcephaly, cutis marmorata, short stature and XY gonadal dysgenesis: variable expression of El-Shanti syndrome. (14691719)
2004
19
Topical tacrolimus (FK506): treatment failure in four cases of alopecia universalis. (12430746)
2002
20
Ineffectiveness of imiquimod therapy for Alopecia Totalis/Universalis. (12224709)
2002
21
An endocrinopathy characterized by dysfunction of the pituitary-adrenal axis and alopecia universalis: supporting the entity of a triple H syndrome. (12213673)
2002
22
Alopecia universalis: failure of dexamethasone pulse therapy. (17664725)
2001
23
Alopecia universalis and Graves' disease in the setting of immune restoration after highly active antiretroviral therapy. (11192862)
2001
24
The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. (10674369)
1999
25
Of hairless mice and men: the genetic basis of congenital alopecia universalis/congenital atrichia. (10575161)
1999
26
Alopecia universalis in a patient with common variable immunodeficiency. (10469418)
1999
27
Alopecia universalis with remission during pregnancy and prednisolone therapy. (9001169)
1997
28
Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis. (8708020)
1996
29
Cytokines in alopecia areata: contrasting cytokine profiles in localized form and extensive form (alopecia universalis). (8982401)
1996
30
Alopecia universalis and cyclosporin A. (8915173)
1996
31
Alopecia universalis in liver transplant patients treated with cyclosporin. (7577610)
1995
32
A case of alopecia universalis without the involvement of scalp hairs. (7740842)
1995
33
Alopecia universalis in a patient with psoriasis vulgaris. (7560464)
1995
34
Pityriasis rubra pilaris, lichen planus, alopecia universalis and vitiligo in a patient with chronic viral hepatitis C. (8186518)
1994
35
Alopecia universalis in a patient seropositive for the human immunodeficiency virus. (8101531)
1993
36
Alopecia universalis in an HIV-positive patient: possible insight into pathogenesis. (8100574)
1993
37
Hairy pigmented congenital naevocellular naevus in a patient with alopecia universalis. (8481996)
1993
38
Angiogenic activity is defective in monocytes from patients with alopecia universalis. (1696299)
1990
39
Alopecia universalis in a patient with Marfan's syndrome. (2272800)
1990
40
Alopecia universalis in autoimmune polyglandular syndrome type I. (2309482)
1990
41
Keratoma hereditaria mutilans (Vohwinkel's disease) with congenital alopecia universalis (atrichia congenita). (2529287)
1989
42
Alopecia universalis as a feature of polyglandular autoimmunity type I. (3176494)
1988
43
Alopecia universalis and Kallman's syndrome. (3792598)
1986
44
Thyroid gland function and autoimmunity in children with alopecia universalis. (3880104)
1985
45
Clinical and immunologic response to Isoprinosine in alopecia areata and alopecia universalis: association with autoantibodies. (2579988)
1985
46
Steroid therapy in alopecia universalis. A case report and review of the literature. (14025161)
1963
47
CATARACTS AND ALOPECIA UNIVERSALIS. (14052008)
1963
48
Trauma as a factor in the production of alopecia universalis: preliminary report. (13099956)
1953
49
Alopecia universalis congenita and hypoplasia renum in a newborn. (20254660)
1947
50
Two Cases of Alopecia Universalis. (19975828)
1912

Genetic Variations for Alopecia Universalis

About this section
Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Alopecia Universalis:

62
id Symbol AA change Variation ID SNP ID
1HRp.Thr1022AlaVAR_005266rs7014851
2HRp.Val1136AspVAR_005267
3HRp.Asp1012AsnVAR_016222

Expression for genes affiliated with Alopecia Universalis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alopecia Universalis

Search GEO for disease gene expression data for Alopecia Universalis.

Pathways for genes affiliated with Alopecia Universalis

About this section
Sources:
29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN
See all sources

Compounds for genes affiliated with Alopecia Universalis

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Alopecia Universalis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
13beta-hydroxy-delta5-steroid4410.1CYP21A2, POMC
2cortrosyn4410.1CYP21A2, POMC
321-deoxycortisol44 2411.0CYP21A2, POMC
4nafarelin44 59 28 1113.0CYP21A2, POMC
5acth 1-244410.0CYP21A2, POMC
6cortisol28 2411.0POMC, CYP21A2
7fludrocortisone44 28 1112.0POMC, CYP21A2
817-hydroxypregnenolone4410.0CYP21A2, POMC
911 deoxycortisol4410.0CYP21A2, POMC
10doca4410.0CYP21A2, POMC
11aminoglutethimide44 1110.9POMC, CYP21A2
12metyrapone59 44 1111.8CYP21A2, POMC
13acth449.8CYP21A2, POMC
14interferon gamma449.7TNF, IFNG
15taurine chloramine449.7IFNG, TNF
16vesnarinone449.7IFNG, TNF
1717-hydroxyprogesterone44 2410.6CYP21A2, POMC
18gold sodium thiomalate449.6TNF, IFNG
19natalizumab44 1110.6IFNG, TNF
20adalimumab44 49 1111.6IFNG, TNF
21clomiphene citrate449.5CYP21A2, INS
22il-12449.5IFNG, TNF
23staurosporin449.4IFNG, TNF
24indoleamine449.3IFNG, TNF
25nash449.3INS, TNF
26budesonide44 49 1111.3IFNG, TNF, POMC
27fluticasone propionate44 49 59 1112.3POMC, TNF, IFNG
28cortisone44 2410.2POMC, CYP21A2, INS
29imiquimod44 28 59 1112.2TNF, IFNG
30dehydroepiandrosterone sulfate449.2POMC, CYP21A2, INS
31dhea449.2INS, CYP21A2, POMC
32androstenedione44 2410.2POMC, CYP21A2, INS
33thyroxine44 2410.1INS, CYP21A2, POMC
34prednisolone44 28 1110.9IFNG, TNF, POMC, CYP21A2
35tacrolimus44 49 1110.7INS, TNF, IFNG
36gnrh448.5INS, CYP21A2, POMC
37hydrocortisone44 2 59 1111.1INS, CYP21A2, POMC, TNF, IFNG
38dexamethasone44 49 28 1111.1IFNG, TNF, POMC, CYP21A2, INS

GO Terms for genes affiliated with Alopecia Universalis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Alopecia Universalis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.2INS, POMC
2extracellular spaceGO:0056157.4INS, POMC, LIPH, TNF, IFNG

Biological processes related to Alopecia Universalis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.6TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.6IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IFNG
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.5IFNG, TNF
5negative regulation of growth of symbiont in hostGO:0441309.4TNF, IFNG
6positive regulation of osteoclast differentiationGO:0456729.4TNF, IFNG
7protein import into nucleus, translocationGO:0000609.3IFNG, TNF
8humoral immune responseGO:0069599.3AIRE, TNF, IFNG
9negative regulation of lipid catabolic processGO:0509959.2INS, TNF
10extrinsic apoptotic signaling pathwayGO:0971919.0TNF, IFNG
11positive regulation of mitosisGO:0458409.0INS, TNF
12positive regulation of cytokine secretionGO:0507158.9INS, TNF
13positive regulation of nitric oxide biosynthetic processGO:0454298.8INS, TNF, IFNG
14regulation of insulin secretionGO:0507968.7INS, TNF, IFNG

Products for genes affiliated with Alopecia Universalis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alopecia Universalis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet