MCID: ALP001
MIFTS: 57

Alopecia Universalis malady

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Alopecia Universalis

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 24GeneTests, 26GTR, 29ICD10, 30ICD10 via Orphanet, 36MedGen, 38MeSH, 39MESH via Orphanet, 47NIH Rare Diseases, 51OMIM, 53Orphanet, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Alopecia Universalis:

Name: Alopecia Universalis 51 11 47 24 53 69 12 13 67
Alopecia Universalis Congenita 11 69 26
Alopecia Areata Universalis 47
 
Atrichia Generalized 69
Alunc 69
Au 47

Characteristics:

Orphanet epidemiological data:

53
alopecia universalis:
Prevalence: 1-5/10000 (Europe)

HPO:

63
alopecia universalis:
Inheritance: autosomal recessive inheritance

Classifications:

Orphanet: 53 
Rare skin diseases


External Ids:

OMIM51 203655
Disease Ontology11 DOID:0050634
Orphanet53 ORPHA701
MESH via Orphanet39 C537055
UMLS via Orphanet68 C0263505
ICD10 via Orphanet30 L63.1
MedGen36 C1859877
MeSH38 D000505
ICD1029 L63.1

Summaries for Alopecia Universalis

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NIH Rare Diseases:47 Alopecia universalis (AU) is a condition characterized by the complete loss of hair on the scalp and body. It is an advanced form of alopecia areata, a condition that causes round patches of hair loss. Although the exact cause of AU is unknown, it is thought to be an autoimmune condition in which an affected person's immune system mistakenly attacks the hair follicles. Roughly 20% of affected people have a family member with alopecia, suggesting that genetic factors may contribute to the development of AU. There is currently no cure for AU, but sometimes hair regrowth occurs on it's own, even after many years. Last updated: 11/23/2014

MalaCards based summary: Alopecia Universalis, also known as alopecia universalis congenita, is related to alopecia and systemic lupus erythematosus, and has symptoms including abnormality of the eyelashes, alopecia and aplasia/hypoplasia of the eyebrow. An important gene associated with Alopecia Universalis is HR (HR, Lysine Demethylase And Nuclear Receptor Corepressor), and among its related pathways are Hypertrophy Model and OX40 Pathway. Affiliated tissues include skin, pituitary and thyroid, and related mouse phenotypes are liver/biliary system and neoplasm.

UniProtKB/Swiss-Prot:69 Alopecia universalis congenita: A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.

Wikipedia:70 Alopecia universalis (AU) or alopecia areata universalis is a medical condition involving loss of all... more...

Description from OMIM:51 203655

Related Diseases for Alopecia Universalis

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Diseases related to Alopecia Universalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia30.8ICAM1, TNF
2systemic lupus erythematosus28.3ICAM1, IFNG, IL4, TNF
3rheumatoid arthritis27.7ICAM1, IFNG, IL1A, IL4, TNF
4atrichia with papular lesions26.2AIRE, CYP21A2, HR, ICAM1, IFNG, IL1A
5au-kline syndrome12.1
6alopecia universalis onychodystrophy vitiligo12.0
7cafe-au-lait spots, multiple12.0
8autosomal dominant café au lait spots11.9
9legius syndrome11.7
10watson syndrome11.6
11satoyoshi syndrome11.5
12alopecia areata11.4
13neurofibromatosis, type 111.3
14total hypotrichosis, mari type11.1
15mismatch repair cancer syndrome11.0
16mccune-albright syndrome, somatic, mosaic11.0
17hypotrichosis 711.0
18hyperpigmentation with or without hypopigmentation10.9
19gastrocutaneous syndrome10.8
20fibromatosis multiple non ossifying10.8
21neurofibromatosis, familial spinal10.7
22neurofibromatosis, type 210.7
23chronic hiccups10.4IFNG, IL1A
24autosomal recessive congenital methemoglobinemia10.4AIRE, CYP21A2
25myoclonus epilepsy10.4IFNG, IL4
26eye accommodation disease10.4IFNG, IL4
27chronic rheumatic pericarditis10.4IFNG, IL1A
28motor peripheral neuropathy10.3IFNG, IL4
29nut allergy10.3IFNG, IL4
30thelaziasis10.3IFNG, IL4
31dressler's syndrome10.3AIRE, CYP21A2
32goat milk allergy10.3IFNG, IL4
33thomsen and becker disease10.3IFNG, IL4
34buruli ulcer10.3IFNG, IL4
35kunjin encephalitis10.3AIRE, CYP21A2
36acute gonococcal salpingitis10.3IFNG, IL4
37cervix melanoma10.3IFNG, IL4
38askin's tumor10.3IFNG, IL1A
39multiple system atrophy, cerebellar type10.3IFNG, IL4
40multicentric castleman disease10.3IFNG, IL4
41tetanus neonatorum10.2IFNG, IL4
42neonatal myasthenia gravis10.2AIRE, CYP21A2
43hepatitis10.2
44hepatitis c10.2
45histiocytoid hemangioma10.2IL1A, IL4
46ileitis10.2ICAM1, IL4
47liver disease10.2ICAM1, IL1A
48vibrio vulnificus infection10.1ICAM1, IL4
49cysticercosis10.1ICAM1, IL4
50progressive relapsing multiple sclerosis10.1IFNG, IL4

Graphical network of the top 20 diseases related to Alopecia Universalis:



Diseases related to alopecia universalis

Symptoms for Alopecia Universalis

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Symptoms by clinical synopsis from OMIM:

203655

Clinical features from OMIM:

203655

Human phenotypes related to Alopecia Universalis:

 63 53 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the eyelashes63 hallmark (90%) HP:0000499
2 alopecia63 hallmark (90%) HP:0001596
3 aplasia/hypoplasia of the eyebrow63 hallmark (90%) HP:0100840
4 abnormality of metabolism/homeostasis63 HP:0001939
5 alopecia universalis63 53 Very frequent (99-80%) HP:0002289
6 absent eyelashes53 Very frequent (99-80%)
7 absent eyebrow53 Very frequent (99-80%)
8 alopecia areata53 Very frequent (99-80%)

Drugs & Therapeutics for Alopecia Universalis

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Drugs for Alopecia Universalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Methylprednisoloneapproved, vet_approvedPhase 4115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
2
Prednisoloneapproved, vet_approvedPhase 4115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3
Triamcinoloneapproved, vet_approvedPhase 4482124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
4Peripheral Nervous System AgentsPhase 4, Phase 2, Phase 322776
5Neuroprotective AgentsPhase 41672
6AntiemeticsPhase 43888
7Prednisolone acetatePhase 41153
8Protective AgentsPhase 4, Phase 2, Phase 37190
9Prednisolone phosphatePhase 41153
10Prednisolone hemisuccinatePhase 41153
11Methylprednisolone HemisuccinatePhase 41153
12Methylprednisolone acetatePhase 41153
13Autonomic AgentsPhase 49774
14Antineoplastic Agents, HormonalPhase 45407
15Anti-Inflammatory AgentsPhase 410355
16Gastrointestinal AgentsPhase 48109
17glucocorticoidsPhase 44920
18Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
19HormonesPhase 413979
20Hormone AntagonistsPhase 412778
21Triamcinolone diacetatePhase 4482
22triamcinolone acetonidePhase 4482
23Triamcinolone hexacetonidePhase 4482
24Immunosuppressive AgentsPhase 4, Phase 212770
25OrangeNutraceuticalPhase 4249
26
AcetylcholineapprovedPhase 2, Phase 377651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
27
Bexaroteneapproved, investigationalPhase 2, Phase 343153559-49-082146
Synonyms:
153559-49-0
3-methyl-TTNEB
4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid
4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid
4-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphtalenyl)ethenyl]benzoic acid
4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthaleneyl)vinyl]benzene carboxylic acid
9RA
AC1L32UG
BIDD:PXR0021
Bexaroten
Bexarotene
Bexarotene (USAN/INN)
Bexarotene [USAN]
Bexaroteno
Bexarotenum
Bexarotène
C095105
CHEBI:50859
CHEMBL1023
CID82146
D03106
DB00307
Elan brand of bexarotene
 
HMS2089L14
HSDB 7453
I14-1941
LG 1069
LG-100069
LG100069
LG1069
LG69 compound
LGD 1069
LGD-1069
LGD1069
LS-38306
Ligand brand of bexarotene
MolPort-003-845-030
NCGC00181016-01
P-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
SBB067189
Targret
Targretin
Targretin (TN)
Targretin-gel
Targretyn
Targrexin
UNII-A61RXM4375
bexaroteno
bexarotenum
p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
p-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl]benzoic acid
28Neurotransmitter AgentsPhase 2, Phase 317734
29onabotulinumtoxinAPhase 2, Phase 3626
30Neuromuscular AgentsPhase 2, Phase 31129
31Botulinum Toxins, Type APhase 2, Phase 3630
32abobotulinumtoxinAPhase 2, Phase 3626
33Botulinum ToxinsPhase 2, Phase 3669
34Cholinergic AgentsPhase 2, Phase 33846
35incobotulinumtoxinAPhase 2, Phase 3635
36
Tofacitinibapproved, investigationalPhase 2104477600-75-2
Synonyms:
 
Tasocitinib
Tofacitinibum
37
AbataceptapprovedPhase 2192332348-12-610237
Synonyms:
CTLA4-Ig
 
CTLA4-IgG4m
CTLA4Ig
CTLA4IgG4m
38Protein Kinase InhibitorsPhase 23612
39AntibodiesPhase 26045
40Antirheumatic AgentsPhase 210627
41ImmunoglobulinsPhase 26045
42Antibodies, MonoclonalPhase 23795
43
Apremilastapproved, investigational64608141-41-911561674
Synonyms:
Apremilast
Apremilast (USAN)
Apremilastum
Aprémilast
CC-10004
 
CHEBI:558773
CHEMBL514800
CID11561674
D08860
N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
44Anti-Infective Agents21402
45Anti-Inflammatory Agents, Non-Steroidal4295
46Anti-Bacterial Agents10884
47Analgesics11287
48Analgesics, Non-Narcotic6260
49Angiogenesis Inhibitors4143
50Angiogenesis Modulating Agents4072

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia AreataCompletedNCT01167946Phase 4
2Intralesional Steroids in the Treatment of Alopecia AreataRecruitingNCT01898806Phase 4
3The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia UniversalisCompletedNCT00997815Phase 2, Phase 3
4Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia AreataCompletedNCT00063076Phase 2, Phase 3
5Tofacitnib for the Treatment of Alopecia Areata and VariantsCompletedNCT02197455Phase 2
6A Pilot Study of Tralokinumab in Subjects With Moderate to Severe Alopecia AreataRecruitingNCT02684097Phase 2
7A Study of Secukinumab for the Treatment of Alopecia AreataRecruitingNCT02599129Phase 2
8Topical Tofacitinib for the Treatment of Alopecia Areata and Its VariantsActive, not recruitingNCT02812342Phase 2
9A Study With INCB018424 Phosphate Cream Applied Topically to Subjects With Alopecia Areata (AA)Active, not recruitingNCT02553330Phase 2
10An Open-Label Pilot Study To Evaluate The Efficacy Of Tofacitinib In Moderate To Severe Alopecia Areata, Totalis And UniversalisActive, not recruitingNCT02299297Phase 2
11An Open-Label Single-Arm Clinical Trial to Evaluate The Efficacy of Abatacept in Moderate to Severe Patch Type Alopecia AreataActive, not recruitingNCT02018042Phase 2
12Efalizumab in the Treatment of Alopecia, Phase IIWithdrawnNCT00746980Phase 2
13Abatacept Costimulatory Blockade in the Treatment of Alopecia Totalis/UniversalisWithdrawnNCT01314495Phase 2
14Pilot Study of the Safety and Efficacy of Apremilast in Subjects With Moderate to Severe Alopecia AreataRecruitingNCT02684123
15Alopecia Areata RegistryRecruitingNCT00069589
16Tofacitinib for the Treatment of Alopecia Areata and Its VariantsActive, not recruitingNCT02312882

Search NIH Clinical Center for Alopecia Universalis

Genetic Tests for Alopecia Universalis

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Genetic tests related to Alopecia Universalis:

id Genetic test Affiliating Genes
1 Alopecia Universalis Congenita26
2 Alopecia Universalis24 HR

Anatomical Context for Alopecia Universalis

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MalaCards organs/tissues related to Alopecia Universalis:

35
Skin, Pituitary, Thyroid, Bone, Liver, T cells, Monocytes

Animal Models for Alopecia Universalis or affiliated genes

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MGI Mouse Phenotypes related to Alopecia Universalis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4AIRE, HR, IFNG, IL4, TNF
2MP:00020067.9AIRE, HR, ICAM1, IFNG, IL1A, TNF
3MP:00053797.8AIRE, HR, ICAM1, IFNG, IL4, TNF
4MP:00053917.7AIRE, HR, ICAM1, IFNG, IL4, TNF
5MP:00107717.7HR, ICAM1, IFNG, IL1A, IL4, TNF
6MP:00053817.6AIRE, HR, ICAM1, IFNG, IL4, TNF
7MP:00053877.3AIRE, HR, ICAM1, IFNG, IL1A, IL4
8MP:00053977.3AIRE, HR, ICAM1, IFNG, IL1A, IL4
9MP:00053767.2AIRE, HR, ICAM1, IFNG, IL1A, IL4

Publications for Alopecia Universalis

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Articles related to Alopecia Universalis:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Efficacy of superficial cryotherapy on the eyebrows of patients with alopecia universalis also treated with contact immunotherapy on the scalp: a prospective, split-face comparative study. (28074525)
2017
2
Reversal of Alopecia Universalis by Tofacitinib: A Case Report. (27842401)
2016
3
Hirschsprung's disease associated with alopecia universalis congenita: a case report. (27633379)
2016
4
Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients. (27130559)
2016
5
Topical Ruxolitinib for the Treatment of Alopecia Universalis. (26649829)
2016
6
Childhood follicular mucinosis co-existed with alopecia universalis. (25958720)
2015
7
Autoimmune Polyglandular Syndrome Type 2 with Alopecia Universalis and Hypoparathyroidism. (26591178)
2015
8
Alopecia universalis during treatment with leflunomide and adalimumab - case report. (24770511)
2014
9
Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis. (24940651)
2014
10
Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report. (24558223)
2014
11
Ruxolitinib-Induced Reversal of Alopecia Universalis in a Patient with Essential Thrombocythemia. (25307179)
2014
12
Multicentric calcified trichilemmal cysts with alopecia universalis affecting siblings. (23254735)
2013
13
Exomic sequencing of immune-related genes reveals novel candidate variants associated with alopecia universalis. (23326468)
2013
14
Satoyoshi syndrome: a cause of alopecia universalis in association with neurologic and bony abnormalities. (22612551)
2013
15
Irreversible alopecia universalis during treatment with pegylated interferon-ribavirin for chronic hepatitis C virus infection: Case report and published work review. (23181541)
2012
16
A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. (22116824)
2012
17
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. (21272494)
2011
18
Alopecia universalis following two sequential traffic accidents: possible association with increased Th1 and Th17 cells and decreased Th2 cells. (22259836)
2011
19
Successful treatment of alopecia universalis with alefacept: a case report and review of the literature. (18543595)
2008
20
Reversible alopecia universalis secondary to PEG-interferon alpha-2b and ribavirin combination therapy in a patient with chronic hepatitis C virus infection. (17700271)
2007
21
Alopecia universalis in Down syndrome: response to therapy. (17179625)
2006
22
Alopecia universalis: a rare side effect seen on chronic hepatitis C treatment with peg-IFN and ribavirin. (17101483)
2006
23
Reversible alopecia universalis during treatment with PEG-interferon and ribavirin for chronic hepatitis C. (15920908)
2005
24
Infant alopecia universalis: role of topical PUVA (psoralen ultraviolet A) radiation. (16409283)
2005
25
Turner syndrome female with a small ring X chromosome lacking the XIST, an unexpectedly mild phenotype and an atypical association with alopecia universalis. (15337477)
2004
26
Alopecia universalis associated with Zumbusch-type generalized pustular psoriasis. (12077534)
2002
27
Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis. (12542742)
2002
28
The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. (10674369)
1999
29
Effect of IVIG on the hair regrowth in a common variable immune deficiency patient with alopecia universalis. (10403010)
1999
30
Alopecia universalis associated with a mutation in the human hairless gene. (9445480)
1998
31
Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis. (8708020)
1996
32
Alopecia universalis and cyclosporin A. (8915173)
1996
33
Alopecia universalis in liver transplant patients treated with cyclosporin. (7577610)
1995
34
A case of alopecia universalis without the involvement of scalp hairs. (7740842)
1995
35
E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis. (7511865)
1994
36
Alopecia universalis as a single abnormality in an inbred Pakistani kindred. (8357006)
1993
37
Alopecia universalis in a patient seropositive for the human immunodeficiency virus. (8101531)
1993
38
Down syndrome, alopecia universalis, and trachyonychia. (8346118)
1993
39
Reversal by interleukin-2 of alopecia universalis, mucocutaneous candidiasis, and sexual impotence in a patient with malignant thymoma. (8468726)
1993
40
Simultaneous occurrence of SIADH, secondary hypogonadism and alopecia universalis in a woman with IDDM. (1666359)
1991
41
Porphyria cutanea tarda associated with autoimmune hypothyroidism, vitiligo and alopecia universalis. (1803247)
1991
42
Effective therapy with low dose of oral cyclosporine A and prednisolone for alopecia universalis. (2241589)
1990
43
Alopecia universalis as a feature of polyglandular autoimmunity type I. (3176494)
1988
44
Alopecia universalis in identical twins. (6539757)
1984
45
Bullous pemphigoid and multiple autoimmune diseases. Alopecia universalis, bullous pemphigoid, hypothyroidism, rheumatoid arthritis, and neutropenia in one patient. (6350385)
1983
46
Spontaneous cell-mediated cytotoxicity (SCMC) in patients with alopecia universalis. (6172934)
1981
47
T cell subpopulations and their functions in vitro. A study in patients with alopecia areata and alopecia universalis. (6974701)
1981
48
Steroid therapy in alopecia universalis. A case report and review of the literature. (14025161)
1963
49
Long-term triamcinolone therapy of alopecia universalis. Case report. (14445785)
1959
50
Two Cases of Alopecia Universalis. (19975828)
1912

Variations for Alopecia Universalis

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UniProtKB/Swiss-Prot genetic disease variations for Alopecia Universalis:

69
id Symbol AA change Variation ID SNP ID
1HRp.Thr1022AlaVAR_005266rs7014851
2HRp.Val1136AspVAR_005267rs121434448
3HRp.Asp1012AsnVAR_016222rs121434451

Clinvar genetic disease variations for Alopecia Universalis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1HRNM_005144.4(HR): c.3407T> A (p.Val1136Asp)SNVPathogenicrs121434448GRCh37Chr 8, 21973913: 21973913
2HRHR, IVS12DS, G-A, +1SNVPathogenicChr na, -1: -1
3HRNM_005144.4(HR): c.3034G> A (p.Asp1012Asn)SNVPathogenicrs121434451GRCh37Chr 8, 21976740: 21976740

Expression for genes affiliated with Alopecia Universalis

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Search GEO for disease gene expression data for Alopecia Universalis.

Pathways for genes affiliated with Alopecia Universalis

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Pathways related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNG, IL1A
29.5IFNG, IL4
39.5IFNG, IL4
49.4ICAM1, IFNG
5
Show member pathways
9.2IFNG, TNF
69.2IL1A, TNF
79.0ICAM1, TNF
88.9ICAM1, IFNG, IL4
98.8IFNG, IL1A, TNF
10
Show member pathways
8.8IFNG, IL1A, TNF
118.8IFNG, IL1A, TNF
128.8IFNG, IL1A, TNF
138.7IFNG, IL4, TNF
14
Show member pathways
8.7IFNG, IL4, TNF
15
Show member pathways
8.7IFNG, IL4, TNF
168.7IFNG, IL4, TNF
178.7IL1A, IL4, TNF
188.7IL1A, IL4, TNF
198.6ICAM1, IFNG, TNF
208.6ICAM1, IFNG, TNF
218.6ICAM1, IFNG, TNF
228.6ICAM1, IL1A, TNF
238.5ICAM1, IL4, TNF
24
Show member pathways
8.5ICAM1, IFNG, IL1A, IL4
25
Show member pathways
8.3IFNG, IL1A, IL4, TNF
26
Show member pathways
8.3IFNG, IL1A, IL4, TNF
278.3IFNG, IL1A, IL4, TNF
28
Show member pathways
8.3IFNG, IL1A, IL4, TNF
298.2ICAM1, IFNG, IL1A, TNF
30
Show member pathways
8.1ICAM1, IFNG, IL4, TNF
317.6ICAM1, IFNG, IL1A, IL4, TNF
32
Show member pathways
7.6ICAM1, IFNG, IL1A, IL4, TNF
33
Show member pathways
7.6ICAM1, IFNG, IL1A, IL4, TNF

GO Terms for genes affiliated with Alopecia Universalis

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Cellular components related to Alopecia Universalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.1ICAM1, IFNG, IL4, TNF
2extracellular spaceGO:00056157.6ICAM1, IFNG, IL1A, IL4, TNF

Biological processes related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:004830410.1IFNG, IL4
2positive regulation of MHC class II biosynthetic processGO:004534810.1IFNG, IL4
3defense response to protozoanGO:004283210.1IFNG, IL4
4response to copper ionGO:004668810.0ICAM1, IL1A
5negative regulation of endothelial cell apoptotic processGO:20003529.9ICAM1, IL4
6extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.9IL1A, IL4
7positive regulation of vitamin D biosynthetic processGO:00605579.9IFNG, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:00605599.9IFNG, TNF
9positive regulation of membrane protein ectodomain proteolysisGO:00510449.9IFNG, TNF
10protein import into nucleus, translocationGO:00000609.8IFNG, TNF
11extrinsic apoptotic signaling pathwayGO:00971919.8IFNG, TNF
12positive regulation of mononuclear cell migrationGO:00716779.8IL4, TNF
13positive regulation of osteoclast differentiationGO:00456729.7IFNG, TNF
14positive regulation of cytokine secretionGO:00507159.7IL1A, TNF
15negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.6IL1A, TNF
16negative regulation of growth of symbiont in hostGO:00441309.6IFNG, TNF
17humoral immune responseGO:00069599.4AIRE, IFNG, TNF
18positive regulation of chemokine biosynthetic processGO:00450809.4IFNG, IL4, TNF
19regulation of immune responseGO:00507769.3ICAM1, IFNG, IL4
20cellular response to lipopolysaccharideGO:00712229.0ICAM1, IFNG, TNF
21positive regulation of nitric oxide biosynthetic processGO:00454298.6ICAM1, IFNG, TNF
22positive regulation of transcription, DNA-templatedGO:00458938.4AIRE, IFNG, IL4, TNF
23positive regulation of transcription from RNA polymerase II promoterGO:00459447.9AIRE, IFNG, IL1A, IL4, TNF

Molecular functions related to Alopecia Universalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.3IFNG, IL1A, IL4, TNF

Sources for Alopecia Universalis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet