AU
MCID: ALP001
MIFTS: 59

Alopecia Universalis (AU) malady

Skin category

Summaries for Alopecia Universalis

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Alopecia universalis is an uncommon form of alopecia areata. alopecia areata is hair loss of unknown cause, characterized by round patches of complete baldness. alopecia universalis, which presents itself as the loss of hair over the entire scalp and body, is an autoimmune disease, in which the immune system mistakenly attacks the hair follicles. while there is neither a cure for alopecia areata nor drugs approved for its treatment, some people find that medications approved for other purposes can help hair grow back, at least temporarily. since the hair follicles of individuals with alopecia universalis remain alive, hair regrowth may occur even without treatment and even after many years.  last updated: 5/8/2012

MalaCards: Alopecia Universalis, also known as alopecia universalis congenita, is related to alopecia and alopecia areata, and has symptoms including autosomal recessive inheritance, absent/decreased lashes and hypotrichosis/atrichia/atrichiasis/scalp hairlessness. An important gene associated with Alopecia Universalis is HR (hair growth associated), and among its related pathways are Leishmaniasis and Immune response MIF-mediated glucocorticoid regulation. The compounds 3beta-hydroxy-delta5-steroid and cortrosyn have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone marrow, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Wikipedia:64 Alopecia universalis or alopecia areata universalis is a medical condition involving rapid loss of all... more...

Description from OMIM:47 203655,104000,610753

Aliases & Classifications for Alopecia Universalis

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 20GeneTests, 22GTR, 47OMIM, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Characteristics (Orphanet epidemiological data):

49
alopecia universalis:
Prevalence: 1-5/10000


Aliases & Descriptions:

alopecia universalis 8 9 43 20 22 47 49 61
alopecia universalis congenita 8 43 22 61
loss of all hair on the body 43
alopecia areata universalis 43
generalized atrichia 43
au 43


External Ids:

Disease Ontology8 DOID:0050634
MESH via Orphanet36 C537055
ICD10 via Orphanet26 L63.1
SNOMED-CT via Orphanet58 86166000
UMLS via Orphanet62 C0263505
ICD1025 L63.1

Related Diseases for Alopecia Universalis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alopecia Universalis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia31.7HR, AIRE
2alopecia areata30.9AIRE, IFNG
3vitiligo30.8AIRE, POMC
4hepatitis c30.7IFNG
5thyroiditis30.4POMC
6autoimmune thyroiditis30.3CYP21A2, AIRE, IFNG
7ulcerative colitis30.1TNF
8graves' disease30.1IFNG, AIRE, CYP21A2
9arthritis30.1POMC, TNF, IFNG
10schimke immunoosseous dysplasia29.8CYP21A2, AIRE
11cholera29.8POMC, INS
12polycystic ovary syndrome29.8CYP21A2, INS
13hepatitis a10.5
14alopecia universalis onychodystrophy vitiligo10.5
15alopecia totalis10.4
16alopecia immunodeficiency10.3
17satoyoshi syndrome10.3
18hypothyroidism, autoimmune10.3
19neurofibromatosis10.3
20cafe au lait spots, multiple10.3
21atopic dermatitis10.3
22pernicious anemia10.3
23acute leukemia10.3
24watson syndrome10.3
25crohn's disease10.3
26lichen planus10.3
27n syndrome10.3
28total hypotrichosis, mari type10.3
29twenty-nail dystrophy10.3
30hepatitis c virus10.3
31mccune albright syndrome10.2
32legius syndrome10.2
33neurofibromatosis type 610.2
34marfan syndrome10.1
35bullous pemphigoid10.1
36ichthyosis vulgaris10.1
37porphyria cutanea tarda10.1
38hepatitis e10.1
39systemic lupus erythematosus10.1
40common variable immunodeficiency10.1
41factor viii deficiency10.1
42factor v deficiency10.1
43factor vii deficiency10.1
44pityriasis rubra pilaris10.1
45triple-a syndrome10.1
46sclerosing cholangitis10.1
47amyloidosis10.1
48thymoma10.1
49turner syndrome10.1
50viral hepatitis10.1

Graphical network of the top 20 diseases related to Alopecia Universalis:



Diseases related to alopecia universalis

Clinical Features for Alopecia Universalis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

203655,104000,610753

Clinical synopsis from OMIM:

104000

Symptoms:

49 (show all 6)
  • autosomal recessive inheritance
  • absent/decreased lashes
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • absent/decreased/thin eyebrows
  • decreased body hair/axillar/pubic hairlessness
  • alopecia

Drugs & Therapeutics for Alopecia Universalis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Alopecia Universalis

Drug clinical trials:

Search ClinicalTrials for Alopecia Universalis

Search NIH Clinical Center for Alopecia Universalis

Search CenterWatch for Alopecia Universalis

Genetic Tests for Alopecia Universalis

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Alopecia Universalis:

id Genetic test Affiliating Genes
1 Alopecia Universalis20 22 HR
2 Alopecia Universalis Congenita22

Anatomical Context for Alopecia Universalis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Alopecia Universalis:

33
Skin, Liver, Bone marrow, Thyroid, Adrenal gland, Monocytes, T cells, Pituitary

Animal Models for Alopecia Universalis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Alopecia Universalis

Sources:
51PubMed
See all sources

Articles related to Alopecia Universalis:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Alopecia Universalis Associated with Vitiligo in an 18-year-old HIV-positive Patient: Highly Active Anti-retroviral Therapy as First Choice Therapy? (23824261)
2014
2
Multicentric calcified trichilemmal cysts with alopecia universalis affecting siblings. (23254735)
2013
3
RenbAPk phenomenon in a patient with alopecia areata universalis. (22911207)
2012
4
Irreversible alopecia universalis during treatment with pegylated interferon-ribavirin for chronic hepatitis C virus infection: Case report and published work review. (23181541)
2012
5
RenbAPk phenomenon in a patient with alopecia areata universalis and psoriasis. (22150402)
2012
6
Clinical characteristics and prognostic factors in early-onset alopecia totalis and alopecia universalis. (22787378)
2012
7
A case of alopecia universalis with agminated lentiginosis and multiple cafAc-au-lait macules: a synchronous coincidence? (22182389)
2012
8
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. (21272494)
2011
9
Alopecia universalis following two sequential traffic accidents: possible association with increased Th1 and Th17 cells and decreased Th2 cells. (22259836)
2011
10
Bimatoprost in the treatment of eyelash universalis alopecia areata. (21712909)
2010
11
Latanoprost in the treatment of eyelash alopecia in alopecia areata universalis. (20028444)
2010
12
Pernicious anemia in a patient with Type 1 diabetes mellitus and alopecia areata universalis. (18614380)
2009
13
Alopecia areata universalis after phenobarbital-induced anti-convulsant hypersensitivity syndrome. (19811415)
2009
14
Successful treatment of alopecia universalis with alefacept: a case report and review of the literature. (18543595)
2008
15
Alopecia areata universalis during treatment of rheumatoid arthritis with anti-TNF-alpha antibody (adalimumab). (18849606)
2008
16
Alopecia areata universalis elicited during treatment with adalimumab. (18230980)
2008
17
Alopecia universalis associated with impaired interleukin-4 production and low serum IgE level. (17637364)
2007
18
Infant alopecia universalis: role of topical PUVA (psoralen ultraviolet A) radiation. (16409283)
2005
19
Alopecia areata universalis and disseminated mollusca contagiosa in atopic dermatitis. Hair re-growth during treatment with interferon gamma--therapeutic effect or coincidence?]. (15892847)
2005
20
Complete remission of alopecia universalis after allogeneic hematopoietic stem cell transplantation. (15073031)
2005
21
Alopecia universalis congenita, XY gonadal dysgenesis and laryngomalacia: a novel malformation syndrome. (12486505)
2003
22
Case study of alopecia universalis and web-based news groups. (12746592)
2003
23
Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis. (12542742)
2002
24
Alopecia universalis completely resolved following autologous bone marrow transplantation. (12164760)
2002
25
Topical tacrolimus (FK506): treatment failure in four cases of alopecia universalis. (12430746)
2002
26
Alopecia universalis in a case of systemic lupus erythematosus. (12421036)
2002
27
Alopecia universalis associated with a mutation in the human hairless gene. (9445480)
1998
28
Alopecia universalis with remission during pregnancy and prednisolone therapy. (9001169)
1997
29
Alopecia universalis in liver transplant patients treated with cyclosporin. (7577610)
1995
30
A case of alopecia universalis without the involvement of scalp hairs. (7740842)
1995
31
Alopecia universalis in a patient with psoriasis vulgaris. (7560464)
1995
32
E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis. (7511865)
1994
33
Alopecia universalis as a single abnormality in an inbred Pakistani kindred. (8357006)
1993
34
Alopecia universalis in a patient seropositive for the human immunodeficiency virus. (8101531)
1993
35
Down syndrome, alopecia universalis, and trachyonychia. (8346118)
1993
36
Alopecia universalis in an HIV-positive patient: possible insight into pathogenesis. (8100574)
1993
37
Hairy pigmented congenital naevocellular naevus in a patient with alopecia universalis. (8481996)
1993
38
Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice. (1536782)
1992
39
Congenital alopecia universalis. (2632563)
1989
40
Alopecia universalis as a feature of polyglandular autoimmunity type I. (3176494)
1988
41
Thyroid gland function and autoimmunity in children with alopecia universalis. (3880104)
1985
42
Clinical and immunologic response to Isoprinosine in alopecia areata and alopecia universalis: association with autoantibodies. (2579988)
1985
43
Alopecia universalis in identical twins. (6539757)
1984
44
T cell subpopulations and their functions in vitro. A study in patients with alopecia areata and alopecia universalis. (6974701)
1981
45
Alopecia universalis. A manifestation of occult amyloidosis and multiple myeloma. (7316563)
1981
46
Steroid therapy in alopecia universalis. A case report and review of the literature. (14025161)
1963
47
CATARACTS AND ALOPECIA UNIVERSALIS. (14052008)
1963
48
The treatment of alopecia universalis with methyl prednisolone (medrol); associated with vitiligo involving arms, forearms, neck, and thigh. (13648966)
1959
49
Alopecia universalis in cirrhosis. (13256811)
1955
50
Alopecia universalis congenita and hypoplasia renum in a newborn. (20254660)
1947

Genetic Variations for Alopecia Universalis

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Alopecia Universalis:

63
id Symbol AA change Variation SNP ID
1HRp.Thr1022AlaVAR_005266rs7014851
2HRp.Val1136AspVAR_005267
3HRp.Asp1012AsnVAR_016222

Expression for genes affiliated with Alopecia Universalis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alopecia Universalis

Search GEO for disease gene expression data for Alopecia Universalis.

Pathways for genes affiliated with Alopecia Universalis

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN
See all sources

Compounds for genes affiliated with Alopecia Universalis

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Alopecia Universalis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
13beta-hydroxy-delta5-steroid4510.1CYP21A2, POMC
2cortrosyn4510.1CYP21A2, POMC
321-deoxycortisol45 2411.0CYP21A2, POMC
4nafarelin45 60 29 1113.0CYP21A2, POMC
5acth 1-244510.0CYP21A2, POMC
6cortisol29 2411.0POMC, CYP21A2
7fludrocortisone45 29 1112.0POMC, CYP21A2
817-hydroxypregnenolone4510.0CYP21A2, POMC
911 deoxycortisol4510.0CYP21A2, POMC
10doca4510.0CYP21A2, POMC
11aminoglutethimide45 1110.9POMC, CYP21A2
12metyrapone60 45 1111.8CYP21A2, POMC
13acth459.8CYP21A2, POMC
14interferon gamma459.7TNF, IFNG
15taurine chloramine459.7IFNG, TNF
16vesnarinone459.7IFNG, TNF
1717-hydroxyprogesterone45 2410.6CYP21A2, POMC
18gold sodium thiomalate459.6TNF, IFNG
19natalizumab45 1110.6IFNG, TNF
20adalimumab45 50 1111.6IFNG, TNF
21clomiphene citrate459.5CYP21A2, INS
22il-12459.5IFNG, TNF
23staurosporin459.4IFNG, TNF
24indoleamine459.3IFNG, TNF
25nash459.3INS, TNF
26budesonide45 50 1111.3IFNG, TNF, POMC
27fluticasone propionate45 50 60 1112.3POMC, TNF, IFNG
28cortisone45 2410.2POMC, CYP21A2, INS
29imiquimod45 29 60 1112.2TNF, IFNG
30dehydroepiandrosterone sulfate459.2POMC, CYP21A2, INS
31dhea459.2INS, CYP21A2, POMC
32androstenedione45 2410.2POMC, CYP21A2, INS
33thyroxine45 2410.1INS, CYP21A2, POMC
34prednisolone45 29 1110.9IFNG, TNF, POMC, CYP21A2
35tacrolimus45 50 1110.7INS, TNF, IFNG
36gnrh458.5INS, CYP21A2, POMC
37hydrocortisone45 2 60 1111.1INS, CYP21A2, POMC, TNF, IFNG
38dexamethasone45 50 29 1111.1IFNG, TNF, POMC, CYP21A2, INS

GO Terms for genes affiliated with Alopecia Universalis

Sources:
16Gene Ontology
See all sources

Cellular components related to Alopecia Universalis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.2INS, POMC
2extracellular spaceGO:0056157.4INS, POMC, LIPH, TNF, IFNG

Biological processes related to Alopecia Universalis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:0605579.6TNF, IFNG
2positive regulation of calcidiol 1-monooxygenase activityGO:0605599.6IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.5TNF, IFNG
4positive regulation of membrane protein ectodomain proteolysisGO:0510449.5IFNG, TNF
5negative regulation of growth of symbiont in hostGO:0441309.4TNF, IFNG
6positive regulation of osteoclast differentiationGO:0456729.4TNF, IFNG
7protein import into nucleus, translocationGO:0000609.3IFNG, TNF
8humoral immune responseGO:0069599.3AIRE, TNF, IFNG
9negative regulation of lipid catabolic processGO:0509959.2INS, TNF
10extrinsic apoptotic signaling pathwayGO:0971919.0TNF, IFNG
11positive regulation of mitosisGO:0458409.0INS, TNF
12positive regulation of cytokine secretionGO:0507158.9INS, TNF
13positive regulation of nitric oxide biosynthetic processGO:0454298.8INS, TNF, IFNG
14regulation of insulin secretionGO:0507968.7INS, TNF, IFNG

Products for genes affiliated with Alopecia Universalis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alopecia Universalis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet