MCID: ALP001
MIFTS: 57

Alopecia Universalis malady

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Alopecia Universalis

About this section
Sources:
50OMIM, 11Disease Ontology, 46NIH Rare Diseases, 23GeneTests, 13DISEASES, 52Orphanet, 68UniProtKB/Swiss-Prot, 25GTR, 12diseasecard, 66UMLS, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 35MedGen, 37MeSH, 28ICD10, 62The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Alopecia Universalis:

Name: Alopecia Universalis 50 11 46 23 13 52 68 25 12 66
Alopecia Universalis Congenita 11 68 25
Alopecia Areata Universalis 46
 
Atrichia Generalized 68
Alunc 68
Au 46

Characteristics:

Orphanet epidemiological data:

52
alopecia universalis:
Prevalence: 1-5/10000 (Europe)

HPO:

62
alopecia universalis:
Inheritance: autosomal recessive inheritance


Classifications:

Orphanet: 52 
Rare skin diseases


External Ids:

OMIM50 203655
Disease Ontology11 DOID:0050634
Orphanet52 ORPHA701
ICD10 via Orphanet29 L63.1
MESH via Orphanet38 C537055
UMLS via Orphanet67 C0263505
MedGen35 C1859877
MeSH37 D000505
ICD1028 L63.1

Summaries for Alopecia Universalis

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NIH Rare Diseases:46 Alopecia universalis (au) is a condition characterized by the complete loss of hair on the scalp and body. it is an advanced form of alopecia areata, a condition that causes round patches of hair loss. although the exact cause of au is unknown, it is thought to be an autoimmune condition in which an affected person's immune system mistakenly attacks the hair follicles. roughly 20% of affected people have a family member with alopecia, suggesting that genetic factors may contribute to the development of au. there is currently no cure for au, but sometimes hair regrowth occurs on it's own, even after many years. last updated: 11/23/2014

MalaCards based summary: Alopecia Universalis, also known as alopecia universalis congenita, is related to alopecia and systemic lupus erythematosus, and has symptoms including abnormality of the eyelashes, alopecia and aplasia/hypoplasia of the eyebrow. An important gene associated with Alopecia Universalis is HR (Hair Growth Associated), and among its related pathways are Hypertrophy Model and OX40 Pathway. Affiliated tissues include skin, pituitary and thyroid, and related mouse phenotypes are liver/biliary system and neoplasm.

UniProtKB/Swiss-Prot:68 Alopecia universalis congenita: A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.

Wikipedia:69 Alopecia universalis (AU) or alopecia areata universalis is a medical condition involving loss of all... more...

Description from OMIM:50 203655

Related Diseases for Alopecia Universalis

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Diseases related to Alopecia Universalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 266)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia31.5ICAM1, TNF
2systemic lupus erythematosus28.5ICAM1, IFNG, IL4, TNF
3rheumatoid arthritis27.6ICAM1, IFNG, IL1A, IL4, TNF
4atrichia with papular lesions25.9AIRE, CYP21A2, HR, ICAM1, IFNG, IL1A
5alopecia universalis onychodystrophy vitiligo12.1
6au-kline syndrome12.1
7cafe-au-lait spots, multiple12.1
8autosomal dominant café au lait spots12.0
9watson syndrome11.6
10legius syndrome11.5
11total hypotrichosis, mari type11.2
12hypotrichosis 711.1
13alopecia areata10.9
14gastrocutaneous syndrome10.9
15fibromatosis multiple non ossifying10.9
16satoyoshi syndrome10.7
17neurofibromatosis, type 110.7
18autosomal recessive congenital methemoglobinemia10.5AIRE, CYP21A2
19dressler's syndrome10.5AIRE, CYP21A2
20kunjin encephalitis10.5AIRE, CYP21A2
21panner disease10.4IFNG, TNF
22baetz-greenwalt syndrome10.4IFNG, TNF
23autoimmune pancreatitis10.4IFNG, TNF
24graft-versus-host disease, protection against10.4IFNG, TNF
25primary systemic mycosis10.4IFNG, TNF
26addison's disease10.4IFNG, TNF
27pasteurellosis10.4IFNG, TNF
28ring chromosome 1510.4
29amyotrophic lateral sclerosis type 410.4IFNG, TNF
30steatorrhea10.4IFNG, TNF
31hernia of ovary and fallopian tube10.4IFNG, TNF
32stampe sorensen syndrome10.4IFNG, TNF
33potter's syndrome10.4IFNG, TNF
34neonatal myasthenia gravis10.4AIRE, CYP21A2
35sensorineural hearing loss10.3IFNG, TNF
36psychologic dyspareunia10.3IFNG, TNF
37mastocytosis cutaneous with short stature conductive hearing loss and microtia10.3IFNG, TNF
38hemophagocytic lymphohistiocytosis10.3IFNG, TNF
39leukostasis10.3IFNG, TNF
40fibrous histiocytoma10.3IFNG, TNF
41rhizomelic pseudopolyarthritis10.3ICAM1, TNF
42chronic hiccups10.3IFNG, IL1A
43lacrimal system cancer10.3IFNG, TNF
44hepatitis10.3
45hepatitis c10.3
46gastric dilatation10.3IFNG, TNF
47bile duct signet ring cell carcinoma10.3IFNG, TNF
48angioedema10.3ICAM1, TNF
49spastic paraplegia-paget disease of bone syndrome10.3ICAM1, TNF
50chronic rheumatic pericarditis10.3IFNG, IL1A

Graphical network of the top 20 diseases related to Alopecia Universalis:



Diseases related to alopecia universalis

Symptoms for Alopecia Universalis

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Symptoms by clinical synopsis from OMIM:

203655

Clinical features from OMIM:

203655

Symptoms:

 52
  • absent eyelashes
  • absent eyebrow
  • alopecia areata
  • alopecia universalis

HPO human phenotypes related to Alopecia Universalis:

id Description Frequency HPO Source Accession
1 abnormality of the eyelashes hallmark (90%) HP:0000499
2 alopecia hallmark (90%) HP:0001596
3 aplasia/hypoplasia of the eyebrow hallmark (90%) HP:0100840
4 abnormality of metabolism/homeostasis HP:0001939
5 alopecia universalis HP:0002289

Drugs & Therapeutics for Alopecia Universalis

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Drugs for Alopecia Universalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PREDNISOLONE ACETATEPhase 41118
2
PrednisolonePhase 4111850-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3
MethylprednisolonePhase 4111883-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
4glucocorticoidsPhase 44756
5triamcinolone acetonidePhase 4463
6
TriamcinolonePhase 4463124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
7
BexarotenePhase 2, Phase 343153559-49-082146
Synonyms:
153559-49-0
3-methyl-TTNEB
4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid
4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid
4-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphtalenyl)ethenyl]benzoic acid
4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthaleneyl)vinyl]benzene carboxylic acid
9RA
AC1L32UG
BIDD:PXR0021
Bexaroten
Bexarotene
Bexarotene (USAN/INN)
Bexarotene [USAN]
Bexaroteno
Bexarotenum
Bexarotène
C095105
CHEBI:50859
CHEMBL1023
CID82146
D03106
DB00307
Elan brand of bexarotene
 
HMS2089L14
HSDB 7453
I14-1941
LG 1069
LG-100069
LG100069
LG1069
LG69 compound
LGD 1069
LGD-1069
LGD1069
LS-38306
Ligand brand of bexarotene
MolPort-003-845-030
NCGC00181016-01
P-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
SBB067189
Targret
Targretin
Targretin (TN)
Targretin-gel
Targretyn
Targrexin
UNII-A61RXM4375
bexaroteno
bexarotenum
p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
p-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl]benzoic acid
8
AcetylcholinePhase 2, Phase 375251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
9
TofacitinibPhase 298477600-75-2
Synonyms:
 
Tasocitinib
Tofacitinibum
10
AbataceptPhase 2188332348-12-610237
Synonyms:
CTLA4-Ig
 
CTLA4-IgG4m
CTLA4Ig
CTLA4IgG4m
11
Thalidomide106050-35-15426
Synonyms:
( inverted question mark)-Thalidomide
(+)-Thalidomide
(+-)-N-(2,6-dioxo-3-Piperidyl)phthalimide
(+-)-Thalidomide
(+/-)-THALIDOMIDE
(?)-Thalidomide
(±)-N-(2,6-dioxo-3-piperidyl)phthalimide
(±)-thalidomide
.alpha.-(N-Phthalimido)glutarimide
.alpha.-N-Phthalylglutaramide
.alpha.-Phthalimidoglutarimide
1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline
14088-68-7
2,6-Dioxo-3-phthalimidopiperidine
2,6-dioxo-3-phthalimidopiperidine
3-Phthalimidoglutarimide
50-35-1
731-40-8
AB00052362
AC-917
AC1L1KBZ
AC1Q6FJA
AI3-50606
Algosediv
Asidon 3
Asmadion
Asmaval
BPBio1_000159
BRD-A93255169-001-06-9
BRN 0030233
BSPBio_000143
BSPBio_001156
BSPBio_003330
Bio1_000387
Bio1_000876
Bio1_001365
Bio2_000418
Bio2_000898
Bonbrain
Bonbrrin
C07910
C13H10N2O4
CCRIS 8148
CHEBI:105028
CHEMBL468
CID5426
CPD000058524
Calmore
Calmorex
Celgene Brand of Thalidomide
Contergan
Corronarobetin
D00754
D013792
DB01041
Distaval
Distaxal
Distoval
DivK1c_000051
E-217
EINECS 200-031-1
ENMD 0995
EU-0101224
Ectiluran
Enterosediv
Gastrinide
Glupan
Glutanon
Grippex
HMS1362J17
HMS1568H05
HMS1792J17
HMS1922E12
HMS1990J17
HMS2090O05
HMS2093G15
HMS500C13
HSDB 3586
Hippuzon
I06-0197
IDI1_000051
IDI1_002173
IN1061
Imida-Lab
Imida-lab
Imidan
Imidan (peyta)
Imidene
Isomin
K 17
K-17
KBio1_000051
KBio2_000496
KBio2_002322
KBio2_003064
KBio2_004890
KBio2_005632
KBio2_007458
KBio3_000911
KBio3_000912
KBio3_002550
KBio3_002802
KBioGR_000496
KBioGR_001474
KBioGR_002322
KBioSS_000496
KBioSS_002324
Kedavon
Kevadon
LS-109463
LS-140
Lopac0_001224
Lulamin
MLS000069353
MolPort-003-665-582
N-(2,6-Dioxo-3-piperidyl)phthalimide
N-(2,6-dioxo-3-piperidyl)phthalimide
N-Phthalimidoglutamic acid imide
N-Phthaloylglutamimide
N-Phthalyl-glutaminsaeure-imid
N-Phthalyl-glutaminsaeure-imid [German]
N-Phthalylglutamic acid imide
NCGC00015989-03
NCGC00015989-13
NCGC00024708-02
 
NCGC00024708-03
NCGC00024708-04
NCGC00024708-05
NCGC00024708-06
NCGC00024708-07
NCGC00024708-08
NCGC00024708-09
NCI60_023904
NCIOpen2_003188
NINDS_000051
NSC 527179
NSC-66847
NSC527179
NSC66847
NSC91729
NSC91730
Neaufatin
Neo
Neosedyn
Neosydyn
Nerosedyn
Neufatin
Neurodyn
Neurosedin
Neurosedym
Neurosedyn
Nevrodyn
Nibrol
Noctosediv
Noxodyn
Pangul
Pantosediv
Poly-Giron
Polygripan
Predni-Sediv
Prestwick0_000192
Prestwick1_000192
Prestwick2_000192
Prestwick3_000192
Prestwick_463
Pro-Bam M
Pro-ban M
Profarmil
Psycholiquid
Psychotablets
Quetimid
Quietoplex
S1193_Selleck
SAM002564245
SMR000058524
SPBio_000893
SPBio_002064
SPECTRUM1503607
ST51039042
Sandormin
Sedalis
Sedalis sedi-lab
Sedimide
Sedin
Sedisperil
Sedoval
Shin-naito S
Shinnibrol
Sleepan
Slipro
Softenil
Softenon
Spectrum2_000707
Spectrum3_001715
Spectrum4_001087
Spectrum5_001791
Synovir
T144_SIGMA
T150_SIGMA
T151_SIGMA
THALIDOMIDE (AIDS INITIATIVE)
Talargan
Talidomida
Talidomida [INN-Spanish]
Talidomide
Talidomide [DCIT]
Talimol
Talismol
Talizer
Telagan
Telargan
Telargean
Tensival
Thaled
Thaled (TN)
Thalidomide
Thalidomide (+ and -)
Thalidomide (JAN/USP/INN)
Thalidomide (soluble form)
Thalidomide Celgene
Thalidomide Pharmion
Thalidomide [USAN:INN:BAN]
Thalidomidum
Thalidomidum [INN-Latin]
Thalidomine USP26
Thalin
Thalinette
Thalomid
Thalomid (TM)
Thalomid (TN)
Thalomid, Thalidomide
Thalomide
Theophilcholine
UNII-4Z8R6ORS6L
UPCMLD-DP139
UPCMLD-DP139:001
Valgis
Valgraine
WLN: T56 BVNVJ C- DT6VMVTJ
WLN: T56 BVNVJ C- DT6VMVTJ -D
WLN: T56 BVNVJ C- DT6VMVTJ -L
Yodomin
alpha-(N-Phthalimido)glutarimide
alpha-N-Phthalylglutaramide
alpha-Phthalimidoglutarimide
alpha-phthalimidoglutarimide
cMAP_000022
thalidomide
α-(N-phthalimido)glutarimide
α-N-phthalylglutaramide
α-phthalimidoglutarimide
12
Apremilast60608141-41-911561674
Synonyms:
Apremilast
Apremilast (USAN)
Apremilastum
Aprémilast
CC-10004
 
CHEBI:558773
CHEMBL514800
CID11561674
D08860
N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia AreataCompletedNCT01167946Phase 4
2Intralesional Steroids in the Treatment of Alopecia AreataRecruitingNCT01898806Phase 4
3The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia UniversalisCompletedNCT00997815Phase 2, Phase 3
4Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia AreataCompletedNCT00063076Phase 2, Phase 3
5Tofacitnib for the Treatment of Alopecia Areata and VariantsCompletedNCT02197455Phase 2
6A Study With INCB018424 Phosphate Cream Applied Topically to Subjects With Alopecia Areata (AA)RecruitingNCT02553330Phase 2
7A Pilot Study of Tralokinumab in Subjects With Moderate to Severe Alopecia AreataRecruitingNCT02684097Phase 2
8A Study of Secukinumab for the Treatment of Alopecia AreataRecruitingNCT02599129Phase 2
9An Open-Label Pilot Study To Evaluate The Efficacy Of Tofacitinib In Moderate To Severe Alopecia Areata, Totalis And UniversalisActive, not recruitingNCT02299297Phase 2
10An Open-Label Single-Arm Clinical Trial to Evaluate The Efficacy of Abatacept in Moderate to Severe Patch Type Alopecia AreataActive, not recruitingNCT02018042Phase 2
11Topical Tofacitinib for the Treatment of Alopecia Areata and Its VariantsNot yet recruitingNCT02812342Phase 2
12Efalizumab in the Treatment of Alopecia, Phase IIWithdrawnNCT00746980Phase 2
13Abatacept Costimulatory Blockade in the Treatment of Alopecia Totalis/UniversalisWithdrawnNCT01314495Phase 2
14Alopecia Areata RegistryRecruitingNCT00069589
15Pilot Study of the Safety and Efficacy of Apremilast in Subjects With Moderate to Severe Alopecia AreataRecruitingNCT02684123
16Tofacitinib for the Treatment of Alopecia Areata and Its VariantsActive, not recruitingNCT02312882

Search NIH Clinical Center for Alopecia Universalis

Genetic Tests for Alopecia Universalis

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Genetic tests related to Alopecia Universalis:

id Genetic test Affiliating Genes
1 Alopecia Universalis Congenita25
2 Alopecia Universalis25 23 HR

Anatomical Context for Alopecia Universalis

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MalaCards organs/tissues related to Alopecia Universalis:

34
Skin, Pituitary, Thyroid, Bone, Liver, T cells, Monocytes

Animal Models for Alopecia Universalis or affiliated genes

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MGI Mouse Phenotypes related to Alopecia Universalis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9AIRE, HR, IFNG, IL4, TNF
2MP:00020068.2AIRE, HR, ICAM1, IFNG, IL1A, TNF
3MP:00107718.1HR, ICAM1, IFNG, IL1A, IL4, TNF
4MP:00053818.1AIRE, HR, ICAM1, IFNG, IL4, TNF
5MP:00053797.9AIRE, HR, ICAM1, IFNG, IL4, TNF
6MP:00053917.9AIRE, HR, ICAM1, IFNG, IL4, TNF
7MP:00053877.7AIRE, HR, ICAM1, IFNG, IL1A, IL4
8MP:00053977.6AIRE, HR, ICAM1, IFNG, IL1A, IL4
9MP:00053767.4AIRE, HR, ICAM1, IFNG, IL1A, IL4

Publications for Alopecia Universalis

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Articles related to Alopecia Universalis:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Hirschsprung's disease associated with alopecia universalis congenita: a case report. (27633379)
2016
2
Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients. (27130559)
2016
3
Topical Ruxolitinib for the Treatment of Alopecia Universalis. (26649829)
2016
4
Childhood follicular mucinosis co-existed with alopecia universalis. (25958720)
2015
5
Autoimmune Polyglandular Syndrome Type 2 with Alopecia Universalis and Hypoparathyroidism. (26591178)
2015
6
Alopecia universalis during treatment with leflunomide and adalimumab - case report. (24770511)
2014
7
Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis. (24940651)
2014
8
Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report. (24558223)
2014
9
Ruxolitinib-Induced Reversal of Alopecia Universalis in a Patient with Essential Thrombocythemia. (25307179)
2014
10
Multicentric calcified trichilemmal cysts with alopecia universalis affecting siblings. (23254735)
2013
11
Exomic sequencing of immune-related genes reveals novel candidate variants associated with alopecia universalis. (23326468)
2013
12
Satoyoshi syndrome: a cause of alopecia universalis in association with neurologic and bony abnormalities. (22612551)
2013
13
Irreversible alopecia universalis during treatment with pegylated interferon-ribavirin for chronic hepatitis C virus infection: Case report and published work review. (23181541)
2012
14
A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. (22116824)
2012
15
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. (21272494)
2011
16
Alopecia universalis following two sequential traffic accidents: possible association with increased Th1 and Th17 cells and decreased Th2 cells. (22259836)
2011
17
Successful treatment of alopecia universalis with alefacept: a case report and review of the literature. (18543595)
2008
18
Reversible alopecia universalis secondary to PEG-interferon alpha-2b and ribavirin combination therapy in a patient with chronic hepatitis C virus infection. (17700271)
2007
19
Alopecia universalis in Down syndrome: response to therapy. (17179625)
2006
20
Alopecia universalis: a rare side effect seen on chronic hepatitis C treatment with peg-IFN and ribavirin. (17101483)
2006
21
Reversible alopecia universalis during treatment with PEG-interferon and ribavirin for chronic hepatitis C. (15920908)
2005
22
Infant alopecia universalis: role of topical PUVA (psoralen ultraviolet A) radiation. (16409283)
2005
23
Turner syndrome female with a small ring X chromosome lacking the XIST, an unexpectedly mild phenotype and an atypical association with alopecia universalis. (15337477)
2004
24
Alopecia universalis associated with Zumbusch-type generalized pustular psoriasis. (12077534)
2002
25
Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis. (12542742)
2002
26
The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. (10674369)
1999
27
Effect of IVIG on the hair regrowth in a common variable immune deficiency patient with alopecia universalis. (10403010)
1999
28
Alopecia universalis associated with a mutation in the human hairless gene. (9445480)
1998
29
Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis. (8708020)
1996
30
Alopecia universalis and cyclosporin A. (8915173)
1996
31
Alopecia universalis in liver transplant patients treated with cyclosporin. (7577610)
1995
32
A case of alopecia universalis without the involvement of scalp hairs. (7740842)
1995
33
Vitiligo complicating diphencyprone sensitization therapy for alopecia universalis. (8547018)
1995
34
E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis. (7511865)
1994
35
Alopecia universalis as a single abnormality in an inbred Pakistani kindred. (8357006)
1993
36
Alopecia universalis in a patient seropositive for the human immunodeficiency virus. (8101531)
1993
37
Down syndrome, alopecia universalis, and trachyonychia. (8346118)
1993
38
Reversal by interleukin-2 of alopecia universalis, mucocutaneous candidiasis, and sexual impotence in a patient with malignant thymoma. (8468726)
1993
39
Simultaneous occurrence of SIADH, secondary hypogonadism and alopecia universalis in a woman with IDDM. (1666359)
1991
40
Porphyria cutanea tarda associated with autoimmune hypothyroidism, vitiligo and alopecia universalis. (1803247)
1991
41
Effective therapy with low dose of oral cyclosporine A and prednisolone for alopecia universalis. (2241589)
1990
42
Alopecia universalis as a feature of polyglandular autoimmunity type I. (3176494)
1988
43
Alopecia universalis in identical twins. (6539757)
1984
44
Bullous pemphigoid and multiple autoimmune diseases. Alopecia universalis, bullous pemphigoid, hypothyroidism, rheumatoid arthritis, and neutropenia in one patient. (6350385)
1983
45
Spontaneous cell-mediated cytotoxicity (SCMC) in patients with alopecia universalis. (6172934)
1981
46
T cell subpopulations and their functions in vitro. A study in patients with alopecia areata and alopecia universalis. (6974701)
1981
47
Steroid therapy in alopecia universalis. A case report and review of the literature. (14025161)
1963
48
Long-term triamcinolone therapy of alopecia universalis. Case report. (14445785)
1959
49
Two Cases of Alopecia Universalis. (19975828)
1912
50
Alopecia Universalis with Dystrophy of the Nails. (19975834)
1912

Variations for Alopecia Universalis

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UniProtKB/Swiss-Prot genetic disease variations for Alopecia Universalis:

68
id Symbol AA change Variation ID SNP ID
1HRp.Thr1022AlaVAR_005266rs7014851
2HRp.Val1136AspVAR_005267rs121434448
3HRp.Asp1012AsnVAR_016222rs121434451

Clinvar genetic disease variations for Alopecia Universalis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1HRNM_005144.4(HR): c.3407T> A (p.Val1136Asp)single nucleotide variantPathogenicrs121434448GRCh37Chr 8, 21973913: 21973913
2HRHR, IVS12DS, G-A, +1single nucleotide variantPathogenic
3HRNM_005144.4(HR): c.3034G> A (p.Asp1012Asn)single nucleotide variantPathogenicrs121434451GRCh37Chr 8, 21976740: 21976740

Expression for genes affiliated with Alopecia Universalis

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Search GEO for disease gene expression data for Alopecia Universalis.

Pathways for genes affiliated with Alopecia Universalis

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Pathways related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNG, IL1A
29.5IFNG, IL4
39.5IFNG, IL4
4
Show member pathways
9.5IFNG, TNF
59.5IL1A, TNF
69.4ICAM1, IFNG
79.3ICAM1, TNF
8
Show member pathways
9.1IFNG, IL1A, TNF
99.1IFNG, IL1A, TNF
109.1IFNG, IL1A, TNF
119.1IFNG, IL1A, TNF
129.0IFNG, IL4, TNF
139.0IFNG, IL4, TNF
14
Show member pathways
9.0IFNG, IL4, TNF
15
Show member pathways
9.0IFNG, IL4, TNF
169.0IL1A, IL4, TNF
179.0IL1A, IL4, TNF
188.9ICAM1, IFNG, IL4
198.9ICAM1, IFNG, TNF
208.9ICAM1, IFNG, TNF
21
Show member pathways
8.9ICAM1, IFNG, TNF
228.9ICAM1, IFNG, TNF
238.9ICAM1, IL1A, TNF
248.8ICAM1, IL4, TNF
25
Show member pathways
8.6IFNG, IL1A, IL4, TNF
26
Show member pathways
8.6IFNG, IL1A, IL4, TNF
27
Show member pathways
8.6IFNG, IL1A, IL4, TNF
288.6IFNG, IL1A, IL4, TNF
29
Show member pathways
8.5ICAM1, IFNG, IL1A, IL4
308.5ICAM1, IFNG, IL1A, TNF
31
Show member pathways
8.4ICAM1, IFNG, IL4, TNF
327.9ICAM1, IFNG, IL1A, IL4, TNF
33
Show member pathways
7.9ICAM1, IFNG, IL1A, IL4, TNF
34
Show member pathways
7.9ICAM1, IFNG, IL1A, IL4, TNF

GO Terms for genes affiliated with Alopecia Universalis

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Cellular components related to Alopecia Universalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6ICAM1, IFNG, IL4, TNF
2extracellular spaceGO:00056157.9ICAM1, IFNG, IL1A, IL4, TNF

Biological processes related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.2IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IFNG, TNF
3positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IFNG, TNF
4positive regulation of isotype switching to IgG isotypesGO:004830410.1IFNG, IL4
5protein import into nucleus, translocationGO:000006010.1IFNG, TNF
6positive regulation of MHC class II biosynthetic processGO:004534810.1IFNG, IL4
7positive regulation of mononuclear cell migrationGO:007167710.1IL4, TNF
8defense response to protozoanGO:004283210.1IFNG, IL4
9extrinsic apoptotic signaling pathwayGO:009719110.1IFNG, TNF
10positive regulation of cytokine secretionGO:005071510.0IL1A, TNF
11positive regulation of osteoclast differentiationGO:004567210.0IFNG, TNF
12negative regulation of growth of symbiont in hostGO:004413010.0IFNG, TNF
13negative regulation of endothelial cell apoptotic processGO:20003529.9ICAM1, IL4
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.9IL1A, TNF
15response to copper ionGO:00466889.9ICAM1, IL1A
16extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.9IL1A, IL4
17humoral immune responseGO:00069599.7AIRE, IFNG, TNF
18positive regulation of chemokine biosynthetic processGO:00450809.7IFNG, IL4, TNF
19cellular response to lipopolysaccharideGO:00712229.3ICAM1, IFNG, TNF
20regulation of immune responseGO:00507769.3ICAM1, IFNG, IL4
21positive regulation of nitric oxide biosynthetic processGO:00454299.1ICAM1, IFNG, TNF
22positive regulation of transcription, DNA-templatedGO:00458938.8AIRE, IFNG, IL4, TNF
23positive regulation of transcription from RNA polymerase II promoterGO:00459448.2AIRE, IFNG, IL1A, IL4, TNF

Molecular functions related to Alopecia Universalis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.6IFNG, IL1A, IL4, TNF

Sources for Alopecia Universalis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet