ALUNC
MCID: ALP001
MIFTS: 58

Alopecia Universalis (ALUNC) malady

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Alopecia Universalis

Aliases & Descriptions for Alopecia Universalis:

Name: Alopecia Universalis 54 12 50 24 56 66 13 14 69
Alopecia Universalis Congenita 12 66 29
Alopecia Areata Universalis 50
Atrichia Generalized 66
Alunc 66
Au 50

Characteristics:

Orphanet epidemiological data:

56
alopecia universalis
Prevalence: 1-5/10000 (Europe);

HPO:

32
alopecia universalis:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

OMIM 54 203655
Disease Ontology 12 DOID:0050634
Orphanet 56 ORPHA701
MESH via Orphanet 43 C537055
UMLS via Orphanet 70 C0263505
ICD10 via Orphanet 34 L63.1
MedGen 40 C1859877
MeSH 42 D000505
ICD10 33 L63.1

Summaries for Alopecia Universalis

NIH Rare Diseases : 50 alopecia universalis (au) is a condition characterized by the complete loss of hair on the scalp and body. it is an advanced form of alopecia areata, a condition that causes round patches of hair loss. although the exact cause of au is unknown, it is thought to be an autoimmune condition in which an affected person's immune system mistakenly attacks the hair follicles. an interaction between genetic and environmental factors is thought to play a role in the condition's onset. there is currently no cure for au, but sometimes hair regrowth occurs on its own, even after many years. last updated: 5/17/2017

MalaCards based summary : Alopecia Universalis, also known as alopecia universalis congenita, is related to impotence and complex regional pain syndrome, and has symptoms including absent eyelashes, absent eyebrow and alopecia areata. An important gene associated with Alopecia Universalis is HR (HR, Lysine Demethylase And Nuclear Receptor Corepressor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

UniProtKB/Swiss-Prot : 66 Alopecia universalis congenita: A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.

Wikipedia : 71 Alopecia universalis (AU) or alopecia areata universalis is a medical condition involving loss of all... more...

Description from OMIM: 203655

Related Diseases for Alopecia Universalis

Diseases related to Alopecia Universalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 224)
id Related Disease Score Top Affiliating Genes
1 impotence 29.8 IFNG IL1A
2 complex regional pain syndrome 29.6 ICAM1 IFNG TNF
3 rheumatoid arthritis 28.9 ICAM1 IFNG IL1A IL4 TNF
4 au-kline syndrome 12.1
5 alopecia universalis onychodystrophy vitiligo 12.0
6 cafe-au-lait spots, multiple 12.0
7 autosomal dominant café au lait spots 11.9
8 legius syndrome 11.7
9 watson syndrome 11.6
10 alopecia areata 11.5
11 satoyoshi syndrome 11.5
12 neurofibromatosis, type 1 11.3
13 neurofibromatosis 11.2
14 hypotrichosis 7 11.2
15 ring chromosome 15 11.1
16 mccune-albright syndrome, somatic, mosaic 11.0
17 mismatch repair cancer syndrome 11.0
18 hyperpigmentation with or without hypopigmentation 10.9
19 alopecia 10.8
20 gastrocutaneous syndrome 10.8
21 fibromatosis multiple non ossifying 10.8
22 neurofibromatosis, familial spinal 10.7
23 ciliary discoordination, due to random ciliary orientation 10.2 IFNG IL1A
24 hepatitis 10.2
25 hepatitis c 10.2
26 stocco dos santos syndrome 10.2 IFNG TNF
27 distal trisomy 14q 10.2 IFNG TNF
28 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IFNG TNF
29 aniseikonia 10.2 IFNG TNF
30 plantar wart 10.2 IFNG TNF
31 esophagus lymphoma 10.2 IFNG TNF
32 small non-cleaved cell lymphoma 10.2 IL1A TNF
33 complement component 8 deficiency 10.2 AIRE CYP21A2
34 swine influenza 10.2 IL1A TNF
35 amyotrophic lateral sclerosis type 14 10.2 IFNG TNF
36 parametritis 10.2 IFNG TNF
37 anal paget's disease 10.2 IL1A TNF
38 deafness, autosomal recessive 29 10.2 AIRE CYP21A2
39 spastic paraplegia 1 10.2 IFNG TNF
40 parkinson disease 11 10.1 IFNG TNF
41 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.1 IFNG TNF
42 cerebellar disease 10.1 IL1A TNF
43 cyclosporiasis 10.1 IFNG TNF
44 malignant otitis externa 10.1 AIRE CYP21A2
45 uveitis 10.1 ICAM1 TNF
46 chromoblastomycosis 10.1 ICAM1 TNF
47 tick-borne encephalitis 10.1 AIRE CYP21A2
48 right ventricle hypoplasia 10.1 ICAM1 TNF
49 sarcomatoid transitional cell carcinoma 10.1 IL1A TNF
50 steroid dehydrogenase deficiency dental anomalies 10.1 IL1A TNF

Graphical network of the top 20 diseases related to Alopecia Universalis:



Diseases related to Alopecia Universalis

Symptoms & Phenotypes for Alopecia Universalis

Symptoms by clinical synopsis from OMIM:

203655

Clinical features from OMIM:

203655

Human phenotypes related to Alopecia Universalis:

56 32
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 absent eyelashes 56 32 Very frequent (99-80%) HP:0000561
2 absent eyebrow 56 32 Very frequent (99-80%) HP:0002223
3 alopecia universalis 56 32 Very frequent (99-80%) HP:0002289
4 alopecia areata 56 32 Very frequent (99-80%) HP:0002229
5 abnormality of metabolism/homeostasis 32 HP:0001939

GenomeRNAi Phenotypes related to Alopecia Universalis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.55 CYP21A2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.55 CYP21A2 IL4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.55 AIRE CYP21A2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.55 CYP21A2 IL4 AIRE
5 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.55 CYP21A2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.55 IL4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.55 IL4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.55 AIRE
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.55 CYP21A2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.55 IL4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.55 CYP21A2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.55 AIRE
13 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 AIRE

MGI Mouse Phenotypes related to Alopecia Universalis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.95 AIRE HR ICAM1 IFNG IL1A IL4
2 digestive/alimentary MP:0005381 9.93 AIRE HR ICAM1 IFNG IL4 TNF
3 endocrine/exocrine gland MP:0005379 9.91 AIRE HR ICAM1 IFNG IL4 TNF
4 homeostasis/metabolism MP:0005376 9.91 AIRE HR ICAM1 IFNG IL1A IL4
5 immune system MP:0005387 9.87 AIRE HR ICAM1 IFNG IL1A IL4
6 integument MP:0010771 9.73 HR ICAM1 IFNG IL1A IL4 TNF
7 liver/biliary system MP:0005370 9.55 AIRE HR IFNG IL4 TNF
8 neoplasm MP:0002006 9.43 AIRE HR ICAM1 IFNG IL1A TNF
9 vision/eye MP:0005391 9.1 IFNG IL4 TNF AIRE HR ICAM1

Drugs & Therapeutics for Alopecia Universalis

Drugs for Alopecia Universalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4 Antiemetics Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Antineoplastic Agents, Hormonal Phase 4
7 Autonomic Agents Phase 4
8 Gastrointestinal Agents Phase 4
9 glucocorticoids Phase 4
10 Hormone Antagonists Phase 4
11 Hormones Phase 4
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
13 Methylprednisolone acetate Phase 4
14 Methylprednisolone Hemisuccinate Phase 4
15 Neuroprotective Agents Phase 4
16 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
17 Prednisolone acetate Phase 4
18 Prednisolone hemisuccinate Phase 4
19 Prednisolone phosphate Phase 4
20 Protective Agents Phase 4,Phase 2,Phase 3
21 Immunosuppressive Agents Phase 4,Phase 2
22 triamcinolone acetonide Phase 4
23 Triamcinolone diacetate Phase 4
24 Triamcinolone hexacetonide Phase 4
25 Orange Nutraceutical Phase 4
26
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
27
Bexarotene Approved, Investigational Phase 2, Phase 3 153559-49-0 82146
28 abobotulinumtoxinA Phase 2, Phase 3
29 Botulinum Toxins Phase 2, Phase 3
30 Botulinum Toxins, Type A Phase 2, Phase 3
31 Cholinergic Agents Phase 2, Phase 3
32 incobotulinumtoxinA Phase 2, Phase 3
33 Neuromuscular Agents Phase 2, Phase 3
34 Neurotransmitter Agents Phase 2, Phase 3
35 onabotulinumtoxinA Phase 2, Phase 3
36
Tofacitinib Approved, Investigational Phase 2 477600-75-2
37
Abatacept Approved Phase 2 332348-12-6 10237
38 Protein Kinase Inhibitors Phase 2
39 Antirheumatic Agents Phase 2
40 Antibodies Phase 2
41 Antibodies, Monoclonal Phase 2
42 Immunoglobulins Phase 2
43
Apremilast Approved, Investigational 608141-41-9 11561674
44 Analgesics
45 Analgesics, Non-Narcotic
46 Angiogenesis Inhibitors
47 Angiogenesis Modulating Agents
48 Anti-Bacterial Agents
49 Anti-Infective Agents
50 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4
2 Intralesional Steroids in the Treatment of Alopecia Areata Recruiting NCT01898806 Phase 4
3 The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis Completed NCT00997815 Phase 2, Phase 3
4 Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata Completed NCT00063076 Phase 2, Phase 3
5 Tofacitnib for the Treatment of Alopecia Areata and Variants Completed NCT02197455 Phase 2
6 A Pilot Study of Tralokinumab in Subjects With Moderate to Severe Alopecia Areata Recruiting NCT02684097 Phase 2
7 Topical Tofacitinib for the Treatment of Alopecia Areata and Its Variants Active, not recruiting NCT02812342 Phase 2
8 A Study With INCB018424 Phosphate Cream Applied Topically to Subjects With Alopecia Areata (AA) Active, not recruiting NCT02553330 Phase 2
9 Study To Evaluate The Efficacy Of Tofacitinib In Moderate To Severe Alopecia Areata, Totalis And Universalis Active, not recruiting NCT02299297 Phase 2
10 An Open-Label Single-Arm Clinical Trial to Evaluate The Efficacy of Abatacept in Moderate to Severe Patch Type Alopecia Areata Active, not recruiting NCT02018042 Phase 2
11 A Study of Secukinumab for the Treatment of Alopecia Areata Terminated NCT02599129 Phase 2
12 Efalizumab in the Treatment of Alopecia, Phase II Withdrawn NCT00746980 Phase 2
13 Abatacept Costimulatory Blockade in the Treatment of Alopecia Totalis/Universalis Withdrawn NCT01314495 Phase 2
14 Tofacitinib for the Treatment of Alopecia Areata and Its Variants Active, not recruiting NCT02312882
15 Pilot Study of the Safety and Efficacy of Apremilast in Subjects With Moderate to Severe Alopecia Areata Active, not recruiting NCT02684123
16 Alopecia Areata Registry Active, not recruiting NCT00069589
17 Ocular Finding in Alopecia Areata Not yet recruiting NCT03155958

Search NIH Clinical Center for Alopecia Universalis

Genetic Tests for Alopecia Universalis

Genetic tests related to Alopecia Universalis:

id Genetic test Affiliating Genes
1 Alopecia Universalis Congenita 29
2 Alopecia Universalis 24 HR

Anatomical Context for Alopecia Universalis

MalaCards organs/tissues related to Alopecia Universalis:

39
Skin, Thyroid, Pituitary, T Cells, Bone, Liver, Monocytes

Publications for Alopecia Universalis

Articles related to Alopecia Universalis:

(show top 50) (show all 138)
id Title Authors Year
1
Review of treatment for alopecia totalis and alopecia universalis. ( 28378336 )
2017
2
Experience with oral tofacitinib in 8 adolescent patients with alopecia universalis. ( 28325392 )
2017
3
Efficacy of superficial cryotherapy on the eyebrows of patients with alopecia universalis also treated with contact immunotherapy on the scalp: a prospective, split-face comparative study. ( 28074525 )
2017
4
Recovery of hair in the psoriatic plaques of a patient with coexistent alopecia universalis. ( 28492603 )
2017
5
Treatment of alopecia universalis with oral alitretinoin: A case report. ( 28349112 )
2017
6
Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients. ( 27130559 )
2016
7
Reversal of Alopecia Universalis by Tofacitinib: A Case Report. ( 27842401 )
2016
8
Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated With Alopecia Universalis. ( 26630079 )
2016
9
Alopecia universalis as a side effect of pegylated interferon I+-ribavirin combination therapy for hepatitis C: a rare case report. ( 27741937 )
2016
10
Efficacy of tofacitinib in treatment of alopecia universalis in two patients. ( 27306107 )
2016
11
Alopecia universalis in a patient with Sheehan's syndrome. ( 26955590 )
2016
12
Hirschsprung's disease associated with alopecia universalis congenita: a case report. ( 27633379 )
2016
13
Alopecia universalis in a dog with testicular neoplasia. ( 27644142 )
2016
14
Topical Ruxolitinib for the Treatment of Alopecia Universalis. ( 26649829 )
2016
15
Autoimmune Polyglandular Syndrome Type 2 with Alopecia Universalis and Hypoparathyroidism. ( 26591178 )
2015
16
Case of alopecia universalis accompanied by minimal change nephrotic syndrome. ( 26300299 )
2015
17
Childhood follicular mucinosis co-existed with alopecia universalis. ( 25958720 )
2015
18
Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report. ( 24558223 )
2014
19
Alopecia Universalis Associated with Vitiligo in an 18-year-old HIV-positive Patient: Highly Active Anti-retroviral Therapy as First Choice Therapy? ( 23824261 )
2014
20
Alopecia Universalis Successfully Treated With Adalimumab. ( 25322338 )
2014
21
Remission of long-standing alopecia universalis after human immunodeficiency virus infection. ( 24450742 )
2014
22
Alopecia universalis during treatment with leflunomide and adalimumab - case report. ( 24770511 )
2014
23
Ruxolitinib-Induced Reversal of Alopecia Universalis in a Patient with Essential Thrombocythemia. ( 25307179 )
2014
24
Sequential development of psoriasis, alopecia universalis, and vitiligo vulgaris in a human immunodeficiency virus seropositive patient: A unique case report. ( 26396459 )
2014
25
Biochemical and immunological studies on erythrocytes superoxide dismutase modified by nitric oxide in patients with alopecia areata: Implications in alopecia patchy persistent and alopecia universalis. ( 24694751 )
2014
26
Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis. ( 24940651 )
2014
27
Alopecia universalis, renal stones, and hyperuricemia: a familial or an unfamiliar association. ( 24791244 )
2014
28
Alopecia universalis associated with cutaneous T cell lymphoma. ( 24821490 )
2014
29
Autoimmune polyglandular syndrome type 2, alopecia universalis and Crohn's disease. ( 22677116 )
2013
30
Multicentric calcified trichilemmal cysts with alopecia universalis affecting siblings. ( 23254735 )
2013
31
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. ( 24019775 )
2013
32
Alopecia universalis in polyglandular autoimmune syndrome type I. ( 24574702 )
2013
33
Exomic sequencing of immune-related genes reveals novel candidate variants associated with alopecia universalis. ( 23326468 )
2013
34
A case of hypogonadism presented with alopecia universalis. ( 25207137 )
2013
35
Satoyoshi syndrome: a cause of alopecia universalis in association with neurologic and bony abnormalities. ( 22612551 )
2013
36
Clinical characteristics and prognostic factors in early-onset alopecia totalis and alopecia universalis. ( 22787378 )
2012
37
A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. ( 22116824 )
2012
38
Irreversible alopecia universalis during treatment with pegylated interferon-ribavirin for chronic hepatitis C virus infection: Case report and published work review. ( 23181541 )
2012
39
A case of alopecia universalis with agminated lentiginosis and multiple cafAc-au-lait macules: a synchronous coincidence? ( 22182389 )
2012
40
Alopecia universalis following two sequential traffic accidents: possible association with increased Th1 and Th17 cells and decreased Th2 cells. ( 22259836 )
2011
41
Remission of alopecia universalis following successful clinical islet transplantation. ( 21951462 )
2011
42
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. ( 21272494 )
2011
43
Renbok phenomenon and contact sensitization in a patient with alopecia universalis. ( 20404233 )
2010
44
Alopecia universalis, hypothyroidism and pituitary hyperplasia: polyglandular autoimmune syndrome III in a patient in remission from treated Hodgkin lymphoma. ( 22791495 )
2010
45
Neuroimages. Hypertrichosis in alopecia universalis and complex regional pain syndrome. ( 20956794 )
2010
46
Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: an unusual case of autoimmune polyglandular syndrome type 3. ( 19289325 )
2009
47
Successful treatment of alopecia universalis with alefacept: a case report and review of the literature. ( 18543595 )
2008
48
Alopecia universalis with twenty-nail dystrophy (trachyonychia). ( 18627760 )
2008
49
Reversible alopecia universalis secondary to PEG-interferon alpha-2b and ribavirin combination therapy in a patient with chronic hepatitis C virus infection. ( 17700271 )
2007
50
Imiquimod in the treatment of alopecia universalis. ( 17388216 )
2007

Variations for Alopecia Universalis

UniProtKB/Swiss-Prot genetic disease variations for Alopecia Universalis:

66
id Symbol AA change Variation ID SNP ID
1 HR p.Thr1022Ala VAR_005266 rs7014851
2 HR p.Val1136Asp VAR_005267 rs121434448
3 HR p.Asp1012Asn VAR_016222 rs121434451

ClinVar genetic disease variations for Alopecia Universalis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HR NM_005144.4(HR): c.3407T> A (p.Val1136Asp) single nucleotide variant Pathogenic rs121434448 GRCh37 Chromosome 8, 21973913: 21973913
2 HR HR, IVS12DS, G-A, +1 single nucleotide variant Pathogenic
3 HR NM_005144.4(HR): c.3034G> A (p.Asp1012Asn) single nucleotide variant Pathogenic rs121434451 GRCh37 Chromosome 8, 21976740: 21976740

Expression for Alopecia Universalis

Search GEO for disease gene expression data for Alopecia Universalis.

Pathways for Alopecia Universalis

Pathways related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 ICAM1 IFNG IL1A IL4 TNF
2
Show member pathways
12.65 ICAM1 IFNG IL1A IL4 TNF
3
Show member pathways
12.58 ICAM1 IFNG IL1A IL4 TNF
4
Show member pathways
12.45 IFNG IL1A IL4 TNF
5
Show member pathways
12.36 ICAM1 IFNG IL4 TNF
6
Show member pathways
12.28 IFNG IL1A IL4 TNF
7
Show member pathways
12.18 IFNG IL4 TNF
8
Show member pathways
12.18 ICAM1 IFNG IL4 TNF
9
Show member pathways
12.12 IFNG IL1A TNF
10
Show member pathways
12.1 IFNG IL1A IL4 TNF
11 12.08 IFNG IL1A TNF
12
Show member pathways
12.04 IFNG IL4 TNF
13 11.92 IFNG IL1A TNF
14
Show member pathways
11.91 IFNG IL1A IL4 TNF
15 11.88 ICAM1 IFNG IL1A TNF
16 11.87 IFNG IL4 TNF
17 11.79 ICAM1 IL1A TNF
18 11.78 IL1A IL4 TNF
19 11.73 ICAM1 IL1A IL4 TNF
20 11.69 ICAM1 IFNG IL4
21 11.68 IFNG IL4 TNF
22
Show member pathways
11.65 IFNG IL4 TNF
23 11.6 ICAM1 IL4 TNF
24 11.58 ICAM1 IFNG IL1A TNF
25 11.43 ICAM1 IFNG IL1A IL4 TNF
26 11.42 ICAM1 IFNG TNF
27 11.37 IFNG IL1A TNF
28
Show member pathways
11.36 ICAM1 IFNG IL1A TNF
29 11.33 ICAM1 IFNG
30
Show member pathways
11.29 IFNG TNF
31 11.25 ICAM1 IFNG
32 11.22 IL1A TNF
33 11.2 ICAM1 IFNG TNF
34 11.19 IFNG IL4
35 11.15 ICAM1 IL1A IL4 TNF
36 11.14 IFNG IL4 TNF
37 11.08 IFNG IL4
38 11.07 IL1A IL4 TNF
39 11.06 ICAM1 IFNG
40 10.95 IFNG IL1A
41 10.84 ICAM1 TNF
42 10.4 IFNG IL1A IL4 TNF

GO Terms for Alopecia Universalis

Cellular components related to Alopecia Universalis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ICAM1 IFNG IL1A IL4 TNF
2 external side of plasma membrane GO:0009897 8.92 ICAM1 IFNG IL4 TNF

Biological processes related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.89 AIRE IFNG IL4 TNF
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.89 AIRE IFNG IL1A IL4 TNF
3 negative regulation of transcription, DNA-templated GO:0045892 9.87 HR IFNG IL4 TNF
4 regulation of immune response GO:0050776 9.78 ICAM1 IFNG IL4
5 positive regulation of protein phosphorylation GO:0001934 9.73 IFNG IL4 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.69 ICAM1 IFNG TNF
7 positive regulation of interleukin-6 production GO:0032755 9.64 IL1A TNF
8 extrinsic apoptotic signaling pathway GO:0097191 9.64 IFNG TNF
9 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.63 IL1A TNF
10 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.63 IL1A IL4
11 positive regulation of cytokine secretion GO:0050715 9.62 IL1A TNF
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.62 ICAM1 IL4
13 protein import into nucleus, translocation GO:0000060 9.61 IFNG TNF
14 positive regulation of protein complex assembly GO:0031334 9.6 IFNG TNF
15 positive regulation of osteoclast differentiation GO:0045672 9.58 IFNG TNF
16 defense response to protozoan GO:0042832 9.58 IFNG IL4
17 humoral immune response GO:0006959 9.58 AIRE IFNG TNF
18 response to copper ion GO:0046688 9.55 ICAM1 IL1A
19 immune response GO:0006955 9.55 AIRE IFNG IL1A IL4 TNF
20 negative regulation of growth of symbiont in host GO:0044130 9.54 IFNG TNF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 IFNG TNF
22 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 IFNG IL4
23 positive regulation of MHC class II biosynthetic process GO:0045348 9.46 IFNG IL4
24 positive regulation of mononuclear cell migration GO:0071677 9.43 IL4 TNF
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 ICAM1 IFNG TNF
26 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.37 ICAM1 TNF
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
28 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 IFNG TNF
29 positive regulation of chemokine biosynthetic process GO:0045080 8.8 IFNG IL4 TNF

Molecular functions related to Alopecia Universalis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IFNG IL1A IL4 TNF

Sources for Alopecia Universalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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