MCID: ALP001
MIFTS: 57

Alopecia Universalis malady

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Alopecia Universalis

About this section
Sources:
49OMIM, 10Disease Ontology, 11diseasecard, 45NIH Rare Diseases, 22GeneTests, 12DISEASES, 51Orphanet, 67UniProtKB/Swiss-Prot, 24GTR, 65UMLS, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 34MedGen, 36MeSH, 27ICD10, 61The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Alopecia Universalis:

Name: Alopecia Universalis 49 10 11 45 22 12 51 67 24 65
Alopecia Universalis Congenita 10 67 24
Alopecia Areata Universalis 45
 
Atrichia Generalized 67
Alunc 67
Au 45

Characteristics:

Orphanet epidemiological data:

51
alopecia universalis:
Prevalence: 1-5/10000 (Europe)

HPO:

61
alopecia universalis:
Inheritance: autosomal recessive inheritance


Classifications:

Orphanet: 51 
Rare skin diseases


External Ids:

OMIM49 203655
Disease Ontology10 DOID:0050634
Orphanet51 701
ICD10 via Orphanet28 L63.1
MESH via Orphanet37 C537055
UMLS via Orphanet66 C0263505
MedGen34 C1859877
MeSH36 D000505
ICD1027 L63.1
UMLS65 C0263505

Summaries for Alopecia Universalis

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NIH Rare Diseases:45 Alopecia universalis (au) is a condition characterized by the complete loss of hair on the scalp and body. it is an advanced form of alopecia areata, a condition that causes round patches of hair loss. although the exact cause of au is unknown, it is thought to be an autoimmune condition in which an affected person's immune system mistakenly attacks the hair follicles. roughly 20% of affected people have a family member with alopecia, suggesting that genetic factors may contribute to the development of au. there is currently no cure for au, but sometimes hair regrowth occurs on it's own, even after many years. last updated: 11/23/2014

MalaCards based summary: Alopecia Universalis, also known as alopecia universalis congenita, is related to porphyria and atrichia with papular lesions, and has symptoms including abnormality of the eyelashes, alopecia and aplasia/hypoplasia of the eyebrow. An important gene associated with Alopecia Universalis is HR (Hair Growth Associated), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and MSP-RON Signaling. Affiliated tissues include skin, thyroid and prostate, and related mouse phenotypes are liver/biliary system and tumorigenesis.

UniProtKB/Swiss-Prot:67 Alopecia universalis congenita: A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.

Wikipedia:68 Alopecia universalis (AU) or alopecia areata universalis is a medical condition involving rapid loss of... more...

Description from OMIM:49 203655

Related Diseases for Alopecia Universalis

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Diseases related to Alopecia Universalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria30.1IFNG, TNF
2atrichia with papular lesions26.4AIRE, CYP21A2, HLA-DMB, HR, IFNG, TNF
3alopecia universalis onychodystrophy vitiligo12.1
4autosomal dominant café au lait spots12.1
5au-kline syndrome12.1
6watson syndrome11.6
7total hypotrichosis, mari type11.2
8hypotrichosis 711.1
9alopecia areata10.9
10alopecia10.9
11fibromatosis multiple non ossifying10.9
12gastrocutaneous syndrome10.9
13neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-hip dysplasia syndrome due to a point mutation10.9
14satoyoshi syndrome10.7
15neurofibromatosis, type 110.7
16neurofibromatosis10.6
17legius syndrome10.6
18autosomal dominant congenital stationary night blindness10.4AIRE, CYP21A2
19artemis deficiency10.4AIRE, IFNG
20vernal conjunctivitis10.4AIRE, IFNG
21orbital granuloma10.4AIRE, CYP21A2
22autoimmune polyendocrine syndrome type 210.4AIRE, CYP21A2
23ring chromosome 1510.4
24bipolar i disorder10.4AIRE, CYP21A2
25vulvar disease10.3AIRE, IFNG
26hepatitis10.3
27hepatitis c10.3
28autoimmune oophoritis10.3IFNG, TNF
29non-distal monosomy 10q10.3IFNG, TNF
30ethmoid sinus squamous cell carcinoma10.3IFNG, TNF
31parasitic ichthyosporea infectious disease10.3IFNG, TNF
32gonococcal bursitis10.3IFNG, TNF
33opisthorchiasis10.3IFNG, TNF
34collagenous colitis10.3IFNG, TNF
35plantar wart10.3AIRE, CYP21A2
36hypercementosis10.3IFNG, TNF
37early-onset, autosomal dominant alzheimer disease10.3IFNG, TNF
38soft tissue sarcoma childhood10.3IFNG, TNF
39hydronephrosis10.3IFNG, TNF
40argentine hemorrhagic fever10.3IFNG, TNF
41b cell deficiency10.3IFNG, TNF
42cytoplasmic body myopathy10.3IFNG, TNF
43hemorrhagic proctocolitis10.3IFNG, TNF
44dancing eyes-dancing feet syndrome10.3IFNG, TNF
45hemolytic anemia10.3IFNG, TNF
46cryptosporidiosis10.2IFNG, TNF
47central nervous system melanocytic neoplasm10.2IFNG, TNF
48proliferative fasciitis10.2IFNG, TNF
49soft palate cancer10.2IFNG, TNF
50chronic tic disorder10.2IFNG, TNF

Graphical network of the top 20 diseases related to Alopecia Universalis:



Diseases related to alopecia universalis

Symptoms for Alopecia Universalis

About this section

Symptoms by clinical synopsis from OMIM:

203655

Clinical features from OMIM:

203655

Symptoms:

 51
  • absent/decreased/thin eyebrows
  • absent/decreased lashes
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • decreased body hair/axillar/pubic hairlessness
  • alopecia
  • autosomal recessive inheritance

HPO human phenotypes related to Alopecia Universalis:

id Description Frequency HPO Source Accession
1 abnormality of the eyelashes hallmark (90%) HP:0000499
2 alopecia hallmark (90%) HP:0001596
3 aplasia/hypoplasia of the eyebrow hallmark (90%) HP:0100840
4 alopecia universalis HP:0002289
5 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Alopecia Universalis

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Drugs for Alopecia Universalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PrednisoloneapprovedPhase 4108250-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Omnipred
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
2
MethylprednisoloneapprovedPhase 4108283-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
3
TriamcinoloneapprovedPhase 4448124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
4Prednisolone acetatePhase 41082
5Anti-Inflammatory AgentsPhase 48478
6Peripheral Nervous System AgentsPhase 4, Phase 2, Phase 318510
7Prednisolone hemisuccinatePhase 41082
8Prednisolone phosphatePhase 41082
9Gastrointestinal AgentsPhase 46401
10Protective AgentsPhase 4, Phase 2, Phase 35651
11AntiemeticsPhase 43213
12Neuroprotective AgentsPhase 41376
13Hormone AntagonistsPhase 410002
14glucocorticoidsPhase 43896
15HormonesPhase 411748
16Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
17Methylprednisolone HemisuccinatePhase 41082
18Methylprednisolone acetatePhase 41082
19Antineoplastic Agents, HormonalPhase 44256
20triamcinolone acetonidePhase 4448
21Triamcinolone hexacetonidePhase 4448
22Triamcinolone diacetatePhase 4448
23Immunosuppressive AgentsPhase 4, Phase 210422
24Immunologic FactorsPhase 4, Phase 218483
25OrangeNutraceuticalPhase 4217
26
Bexaroteneapproved, investigationalPhase 2, Phase 343153559-49-082146
Synonyms:
153559-49-0
3-methyl-TTNEB
4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid
4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid
4-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphtalenyl)ethenyl]benzoic acid
4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthaleneyl)vinyl]benzene carboxylic acid
9RA
AC1L32UG
BIDD:PXR0021
Bexaroten
Bexarotene
Bexarotene (USAN/INN)
Bexarotene [USAN]
Bexaroteno
Bexarotenum
Bexarotène
C095105
CHEBI:50859
CHEMBL1023
CID82146
D03106
DB00307
Elan brand of bexarotene
 
HMS2089L14
HSDB 7453
I14-1941
LG 1069
LG-100069
LG100069
LG1069
LG69 compound
LGD 1069
LGD-1069
LGD1069
LS-38306
Ligand brand of bexarotene
MolPort-003-845-030
NCGC00181016-01
P-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
SBB067189
Targret
Targretin
Targretin (TN)
Targretin-gel
Targretyn
Targrexin
UNII-A61RXM4375
bexaroteno
bexarotenum
p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
p-[1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl]benzoic acid
27
AcetylcholineexperimentalPhase 2, Phase 368951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
28Neuromuscular AgentsPhase 2, Phase 3922
29OnabotulinumtoxinAPhase 2, Phase 3588
30IncobotulinumtoxinAPhase 2, Phase 3599
31Neurotransmitter AgentsPhase 2, Phase 314795
32Cholinergic AgentsPhase 2, Phase 33243
33AbobotulinumtoxinAPhase 2, Phase 3588
34Botulinum ToxinsPhase 2, Phase 3616
35Botulinum Toxins, Type APhase 2, Phase 3588
36
TofacitinibapprovedPhase 295477600-75-2
Synonyms:
Tasocitinib
 
Tofacitinib Citrate
Tofacitinibum
Xeljanz
37
AbataceptapprovedPhase 2139332348-12-610237
Synonyms:
CTLA4-Ig
CTLA4-IgG4m
 
CTLA4Ig
CTLA4IgG4m
Orencia
38Antirheumatic AgentsPhase 28496
39Protein Kinase InhibitorsPhase 23162
40Contraceptives, Oral3734
41
Apremilast58608141-41-911561674
Synonyms:
Apremilast
Apremilast (USAN)
CC-10004
 
CHEBI:558773
CHEMBL514800
CID11561674
D08860
N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
42Analgesics, Non-Narcotic5184
43Analgesics9358
44Anti-Inflammatory Agents, Non-Steroidal3549

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia AreataCompletedNCT01167946Phase 4
2Intralesional Steroids in the Treatment of Alopecia AreataRecruitingNCT01898806Phase 4
3The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia UniversalisCompletedNCT00997815Phase 2, Phase 3
4Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia AreataCompletedNCT00063076Phase 2, Phase 3
5A Study With INCB018424 Phosphate Cream Applied Topically to Subjects With Alopecia Areata (AA)RecruitingNCT02553330Phase 2
6A Pilot Study of Tralokinumab in Subjects With Moderate to Severe Alopecia AreataRecruitingNCT02684097Phase 2
7A Study of Secukinumab for the Treatment of Alopecia AreataRecruitingNCT02599129Phase 2
8Tofacitnib for the Treatment of Alopecia Areata and VariantsActive, not recruitingNCT02197455Phase 2
9An Open-Label Pilot Study To Evaluate The Efficacy Of Tofacitinib In Moderate To Severe Alopecia Areata, Totalis And UniversalisActive, not recruitingNCT02299297Phase 2
10An Open-Label Single-Arm Clinical Trial to Evaluate The Efficacy of Abatacept in Moderate to Severe Patch Type Alopecia AreataActive, not recruitingNCT02018042Phase 2
11Efalizumab in the Treatment of Alopecia, Phase IIWithdrawnNCT00746980Phase 2
12Abatacept Costimulatory Blockade in the Treatment of Alopecia Totalis/UniversalisWithdrawnNCT01314495Phase 2
13Alopecia Areata RegistryRecruitingNCT00069589
14A Randomized Placebo-controlled Single Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects With Moderate to Severe Alopecia AreataRecruitingNCT02684123
15Tofacitinib for the Treatment of Alopecia Areata and Its VariantsActive, not recruitingNCT02312882

Search NIH Clinical Center for Alopecia Universalis

Genetic Tests for Alopecia Universalis

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Genetic tests related to Alopecia Universalis:

id Genetic test Affiliating Genes
1 Alopecia Universalis22 HR

Anatomical Context for Alopecia Universalis

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MalaCards organs/tissues related to Alopecia Universalis:

33
Skin, Thyroid, Prostate, Liver, Breast, Bone, Cervix

Animal Models for Alopecia Universalis or affiliated genes

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MGI Mouse Phenotypes related to Alopecia Universalis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0AIRE, HR, IFNG, TNF
2MP:00020069.0AIRE, HR, IFNG, TNF

Publications for Alopecia Universalis

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Articles related to Alopecia Universalis:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated With Alopecia Universalis. (26630079)
2016
2
Alopecia universalis, renal stones, and hyperuricemia: a familial or an unfamiliar association. (24791244)
2014
3
Alopecia universalis during treatment with leflunomide and adalimumab - case report. (24770511)
2014
4
Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis. (24940651)
2014
5
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. (24019775)
2013
6
Multicentric calcified trichilemmal cysts with alopecia universalis affecting siblings. (23254735)
2013
7
Exomic sequencing of immune-related genes reveals novel candidate variants associated with alopecia universalis. (23326468)
2013
8
Satoyoshi syndrome: a cause of alopecia universalis in association with neurologic and bony abnormalities. (22612551)
2013
9
Irreversible alopecia universalis during treatment with pegylated interferon-ribavirin for chronic hepatitis C virus infection: Case report and published work review. (23181541)
2012
10
A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. (22116824)
2012
11
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. (21272494)
2011
12
Renbok phenomenon and contact sensitization in a patient with alopecia universalis. (20404233)
2010
13
Alopecia universalis with twenty-nail dystrophy (trachyonychia). (18627760)
2008
14
Alopecia universalis associated with impaired interleukin-4 production and low serum IgE level. (17637364)
2007
15
Alopecia universalis treated with bone morphogenetic protein? (16403121)
2006
16
Reversible alopecia universalis during treatment with PEG-interferon and ribavirin for chronic hepatitis C. (15920908)
2005
17
Atrichia with papular lesions resulting from compound heterozygous mutations in the hairless gene: A lesson for differential diagnosis of alopecia universalis. (12271294)
2002
18
Severe dermographism after topical therapy with diphenylcyclopropenone for alopecia universalis. (10750852)
2000
19
The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. (10674369)
1999
20
Alopecia universalis associated with a mutation in the human hairless gene. (9445480)
1998
21
Alopecia universalis with remission during pregnancy and prednisolone therapy. (9001169)
1997
22
Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis. (8708020)
1996
23
Cytokines in alopecia areata: contrasting cytokine profiles in localized form and extensive form (alopecia universalis). (8982401)
1996
24
Alopecia universalis and cyclosporin A. (8915173)
1996
25
Alopecia universalis in liver transplant patients treated with cyclosporin. (7577610)
1995
26
HLA class II alleles in long-standing alopecia totalis/alopecia universalis and long-standing patchy alopecia areata differentiate these two clinical groups. (7738393)
1995
27
Rapid hair regrowth in refractory alopecia universalis associated with autoimmune disease following liver transplantation and tacrolimus (FK506) therapy. (7539169)
1995
28
A case of alopecia universalis without the involvement of scalp hairs. (7740842)
1995
29
E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis. (7511865)
1994
30
Alopecia universalis as a single abnormality in an inbred Pakistani kindred. (8357006)
1993
31
Alopecia universalis in a patient seropositive for the human immunodeficiency virus. (8101531)
1993
32
Down syndrome, alopecia universalis, and trachyonychia. (8346118)
1993
33
Failure of passive transfer of serum from patients with alopecia areata and alopecia universalis to inhibit hair growth in transplants of human scalp skin grafted on to nude mice. (1536782)
1992
34
Alopecia universalis treated with oral cyclosporine A and prednisolone: immunologic studies. (1500249)
1992
35
Simultaneous occurrence of SIADH, secondary hypogonadism and alopecia universalis in a woman with IDDM. (1666359)
1991
36
Application of psychoimmunotherapy in patients with alopecia universalis. (1801046)
1991
37
Effective therapy with low dose of oral cyclosporine A and prednisolone for alopecia universalis. (2241589)
1990
38
Angiogenic activity is defective in monocytes from patients with alopecia universalis. (1696299)
1990
39
Alopecia universalis in a patient with Marfan's syndrome. (2272800)
1990
40
Congenital alopecia universalis. (2632563)
1989
41
Alopecia universalis as a feature of polyglandular autoimmunity type I. (3176494)
1988
42
Hair growth in scalp grafts from patients with alopecia areata and alopecia universalis grafted onto nude mice. (3800422)
1987
43
Alopecia universalis in identical twins. (6539757)
1984
44
Spontaneous cell-mediated cytotoxicity (SCMC) in patients with alopecia universalis. (6172934)
1981
45
T cell subpopulations and their functions in vitro. A study in patients with alopecia areata and alopecia universalis. (6974701)
1981
46
Long-term triamcinolone therapy of alopecia universalis. Case report. (14445785)
1959
47
The treatment of alopecia universalis with methyl prednisolone (medrol); associated with vitiligo involving arms, forearms, neck, and thigh. (13648966)
1959
48
Alopecia universalis congenita and hypoplasia renum in a newborn. (20254660)
1947
49
Two Cases of Alopecia Universalis. (19975828)
1912
50

Variations for Alopecia Universalis

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UniProtKB/Swiss-Prot genetic disease variations for Alopecia Universalis:

67
id Symbol AA change Variation ID SNP ID
1HRp.Thr1022AlaVAR_005266rs7014851
2HRp.Val1136AspVAR_005267
3HRp.Asp1012AsnVAR_016222

Clinvar genetic disease variations for Alopecia Universalis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1HRNM_005144.4(HR): c.3407T> A (p.Val1136Asp)single nucleotide variantPathogenicrs121434448GRCh37Chr 8, 21973913: 21973913
2HRHR, IVS12DS, G-A, +1single nucleotide variantPathogenic
3HRNM_005144.4(HR): c.3034G> A (p.Asp1012Asn)single nucleotide variantPathogenicrs121434451GRCh37Chr 8, 21976740: 21976740

Expression for genes affiliated with Alopecia Universalis

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Search GEO for disease gene expression data for Alopecia Universalis.

Pathways for genes affiliated with Alopecia Universalis

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GO Terms for genes affiliated with Alopecia Universalis

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Biological processes related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:00605599.9IFNG, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:00510449.9IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:00450809.9IFNG, TNF
4negative regulation of growth of symbiont in hostGO:00441309.8IFNG, TNF
5protein import into nucleus, translocationGO:00000609.7IFNG, TNF
6response to virusGO:00096159.6IFNG, TNF
7positive regulation of cell adhesionGO:00457859.5IFNG, TNF
8positive regulation of osteoclast differentiationGO:00456729.4IFNG, TNF
9defense response to bacteriumGO:00427429.4IFNG, TNF
10regulation of insulin secretionGO:00507969.3IFNG, TNF
11extrinsic apoptotic signaling pathwayGO:00971919.1IFNG, TNF

Sources for Alopecia Universalis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet