MCID: ALP001
MIFTS: 57

Alopecia Universalis

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Alopecia Universalis

MalaCards integrated aliases for Alopecia Universalis:

Name: Alopecia Universalis 54 12 50 24 56 71 13 14 69
Alopecia Universalis Congenita 12 71 29
Alopecia Areata Universalis 50
Atrichia Generalized 71
Alunc 71
Au 50

Characteristics:

Orphanet epidemiological data:

56
alopecia universalis
Prevalence: 1-5/10000 (Europe);

OMIM:

54
Inheritance:
autosomal recessive


HPO:

32
alopecia universalis:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

OMIM 54 203655
Disease Ontology 12 DOID:0050634
Orphanet 56 ORPHA701
MESH via Orphanet 43 C537055
UMLS via Orphanet 70 C0263505
ICD10 via Orphanet 34 L63.1
MedGen 40 C1859877
MeSH 42 D000505
ICD10 33 L63.1

Summaries for Alopecia Universalis

NIH Rare Diseases : 50 alopecia universalis (au) is a condition characterized by the complete loss of hair on the scalp and body. it is an advanced form of alopecia areata, a condition that causes round patches of hair loss. although the exact cause of au is unknown, it is thought to be an autoimmune condition in which an affected person's immune system mistakenly attacks the hair follicles. an interaction between genetic and environmental factors is thought to play a role in the condition's onset. there is currently no cure for au, but sometimes hair regrowth occurs on its own, even after many years. last updated: 9/23/2017

MalaCards based summary : Alopecia Universalis, also known as alopecia universalis congenita, is related to impotence and autoimmune polyglandular syndrome type 3, and has symptoms including absent eyelashes, alopecia areata and absent eyebrow. An important gene associated with Alopecia Universalis is HR (HR, Lysine Demethylase And Nuclear Receptor Corepressor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and digestive/alimentary

UniProtKB/Swiss-Prot : 71 Alopecia universalis congenita: A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.

Wikipedia : 72 Alopecia universalis (AU) or alopecia areata universalis is a medical condition involving loss of all... more...

Description from OMIM: 203655

Related Diseases for Alopecia Universalis

Diseases related to Alopecia Universalis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
id Related Disease Score Top Affiliating Genes
1 impotence 30.3 IFNG IL1A
2 autoimmune polyglandular syndrome type 3 30.3 IFNG TNF
3 lymphoma 30.0 AIRE IFNG TNF
4 rheumatoid arthritis 28.8 ICAM1 IFNG IL1A TNF
5 systemic lupus erythematosus 28.2 ICAM1 IFNG IL2RA TNF
6 atrichia with papular lesions 25.6 AIRE CYP21A2 HR ICAM1 IFNG IL1A
7 au-kline syndrome 12.1
8 alopecia universalis onychodystrophy vitiligo 12.0
9 cafe-au-lait spots, multiple 12.0
10 autosomal dominant café au lait spots 11.9
11 legius syndrome 11.8
12 watson syndrome 11.6
13 neurofibromatosis, type 1 11.4
14 alopecia areata 11.3
15 satoyoshi syndrome 11.3
16 hypotrichosis 7 11.2
17 ring chromosome 15 11.0
18 alopecia, epilepsy, pyorrhea, mental subnormality 11.0
19 mccune-albright syndrome, somatic, mosaic 11.0
20 mismatch repair cancer syndrome 11.0
21 hyperpigmentation with or without hypopigmentation 10.9
22 alopecia 10.8
23 fibromatosis multiple non ossifying 10.8
24 gastrocutaneous syndrome 10.8
25 nijmegen breakage syndrome 10.7
26 odonto onycho dysplasia with alopecia 10.7
27 pinheiro freire-maia miranda syndrome 10.7
28 neurofibromatosis, familial spinal 10.7
29 sternal cleft 10.4 IFNG TNF
30 mosaic trisomy 1 10.4 IFNG TNF
31 combined cellular and humoral immune defects with granulomas 10.4 AIRE IFNG
32 primary systemic mycosis 10.4 IFNG TNF
33 plantar wart 10.4 IFNG TNF
34 oropharyngeal cancer, childhood 10.4 IFNG TNF
35 amyotrophic lateral sclerosis type 10 10.4 IFNG TNF
36 lymphocytic colitis 10.4 IFNG TNF
37 pasteurellosis 10.4 IFNG TNF
38 small intestine lymphoma 10.4 IL1A TNF
39 polyarteritis nodosa 10.4 IFNG TNF
40 sparse hair ptosis mental retardation 10.4 IFNG TNF
41 clopidogrel resistance 10.4 AIRE CYP21A2
42 epstein-barr virus hepatitis 10.4 IL1A TNF
43 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.4 IFNG TNF
44 scrotal carcinoma 10.4 IL1A TNF
45 tularemia 10.3 IFNG TNF
46 lung sarcoma 10.3 IL1A TNF
47 early-onset zonular cataract 10.3 IFNG TNF
48 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.3 IL1A TNF
49 askin's tumor 10.3 IFNG IL1A
50 hepadnavirus infection 10.3 IFNG TNF

Graphical network of the top 20 diseases related to Alopecia Universalis:



Diseases related to Alopecia Universalis

Symptoms & Phenotypes for Alopecia Universalis

Symptoms via clinical synopsis from OMIM:

54

Lab:
no hair in hair follicles on skin biopsy

Hair:
alopecia universalis


Clinical features from OMIM:

203655

Human phenotypes related to Alopecia Universalis:

56 32
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 absent eyelashes 56 32 hallmark (90%) Very frequent (99-80%) HP:0000561
2 alopecia universalis 56 32 hallmark (90%) Very frequent (99-80%) HP:0002289
3 alopecia areata 56 32 hallmark (90%) Very frequent (99-80%) HP:0002229
4 absent eyebrow 56 32 hallmark (90%) Very frequent (99-80%) HP:0002223
5 abnormality of metabolism/homeostasis 32 HP:0001939

GenomeRNAi Phenotypes related to Alopecia Universalis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 CYP21A2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.77 CYP21A2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.77 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.77 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.77 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.77 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.77 AIRE CYP21A2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.77 IL2RA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.77 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.77 IL2RA AIRE CYP21A2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.77 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.77 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.77 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.77 CYP21A2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.77 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.77 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.77 AIRE
18 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.77 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.77 IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 CYP21A2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.77 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.77 CYP21A2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.77 AIRE
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 AIRE
25 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.77 IL2RA

MGI Mouse Phenotypes related to Alopecia Universalis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.88 AIRE HR ICAM1 IFNG IL2RA TNF
2 hematopoietic system MP:0005397 9.87 AIRE HR ICAM1 IFNG IL1A IL2RA
3 endocrine/exocrine gland MP:0005379 9.85 AIRE HR ICAM1 IFNG IL2RA TNF
4 homeostasis/metabolism MP:0005376 9.8 IFNG IL1A IL2RA TNF AIRE HR
5 immune system MP:0005387 9.7 AIRE HR ICAM1 IFNG IL1A IL2RA
6 neoplasm MP:0002006 9.43 AIRE HR ICAM1 IFNG IL1A TNF
7 vision/eye MP:0005391 9.1 HR ICAM1 IFNG IL2RA TNF AIRE

Drugs & Therapeutics for Alopecia Universalis

Drugs for Alopecia Universalis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3 Orange Approved, Nutraceutical Phase 4
4 Antiemetics Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Antineoplastic Agents, Hormonal Phase 4
7 Autonomic Agents Phase 4
8 Gastrointestinal Agents Phase 4
9 glucocorticoids Phase 4
10 Hormone Antagonists Phase 4
11 Hormones Phase 4
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
13 Methylprednisolone acetate Phase 4
14 Methylprednisolone Hemisuccinate Phase 4
15 Neuroprotective Agents Phase 4
16 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
17 Prednisolone acetate Phase 4
18 Prednisolone hemisuccinate Phase 4
19 Prednisolone phosphate Phase 4
20 Protective Agents Phase 4,Phase 2,Phase 3
21
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
22
Bexarotene Approved, Investigational Phase 2, Phase 3 153559-49-0 82146
23 abobotulinumtoxinA Phase 2, Phase 3
24 Botulinum Toxins Phase 2, Phase 3
25 Botulinum Toxins, Type A Phase 2, Phase 3
26 Cholinergic Agents Phase 2, Phase 3
27 Neuromuscular Agents Phase 2, Phase 3
28 Neurotransmitter Agents Phase 2, Phase 3
29 onabotulinumtoxinA Phase 2, Phase 3
30
Tofacitinib Approved, Investigational Phase 2 477600-75-2
31
Abatacept Approved Phase 2 332348-12-6 10237
32 Protein Kinase Inhibitors Phase 2
33 Antirheumatic Agents Phase 2
34 Immunosuppressive Agents Phase 2
35 Antibodies Phase 2
36 Antibodies, Monoclonal Phase 2
37 Immunoglobulins Phase 2
38
Apremilast Approved, Investigational 608141-41-9 11561674
39 Analgesics
40 Analgesics, Non-Narcotic
41 Angiogenesis Inhibitors
42 Angiogenesis Modulating Agents
43 Anti-Bacterial Agents
44 Anti-Infective Agents
45 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
2 The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis Completed NCT00997815 Phase 2, Phase 3 Botulinum toxin A;Normal saline injection
3 Phase II Randomized Bilateral Comparison of Topical Targretin Gel 1% in Alopecia Areata Completed NCT00063076 Phase 2, Phase 3 Targretin Gel 1%
4 Tofacitnib for the Treatment of Alopecia Areata and Variants Completed NCT02197455 Phase 2 Tofacitinib Administration
5 A Pilot Study of Tralokinumab in Subjects With Moderate to Severe Alopecia Areata Recruiting NCT02684097 Phase 2 Tralokinumab;Placebo
6 Topical Tofacitinib for the Treatment of Alopecia Areata and Its Variants Active, not recruiting NCT02812342 Phase 2 Tofacitinib ointment
7 A Study With INCB018424 Phosphate Cream Applied Topically to Subjects With Alopecia Areata (AA) Active, not recruiting NCT02553330 Phase 2 Placebo Cream;INCB018424 Phosphate Cream
8 Study To Evaluate The Efficacy Of Tofacitinib In Moderate To Severe Alopecia Areata, Totalis And Universalis Active, not recruiting NCT02299297 Phase 2 Tofacitinib
9 An Open-Label Single-Arm Clinical Trial to Evaluate The Efficacy of Abatacept in Moderate to Severe Patch Type Alopecia Areata Active, not recruiting NCT02018042 Phase 2 Abatacept
10 A Study of Secukinumab for the Treatment of Alopecia Areata Terminated NCT02599129 Phase 2 Secukinumab;Placebo
11 Efalizumab in the Treatment of Alopecia, Phase II Withdrawn NCT00746980 Phase 2 efalizumab
12 Abatacept Costimulatory Blockade in the Treatment of Alopecia Totalis/Universalis Withdrawn NCT01314495 Phase 2 Abatacept;Inactive infusion
13 Tofacitinib for the Treatment of Alopecia Areata and Its Variants Active, not recruiting NCT02312882 Tofacitinib administration
14 Pilot Study of the Safety and Efficacy of Apremilast in Subjects With Moderate to Severe Alopecia Areata Active, not recruiting NCT02684123 Apremilast;Placebo
15 Alopecia Areata Registry Active, not recruiting NCT00069589
16 Ocular Finding in Alopecia Areata Not yet recruiting NCT03155958

Search NIH Clinical Center for Alopecia Universalis

Genetic Tests for Alopecia Universalis

Genetic tests related to Alopecia Universalis:

id Genetic test Affiliating Genes
1 Alopecia Universalis Congenita 29
2 Alopecia Universalis 24 HR

Anatomical Context for Alopecia Universalis

MalaCards organs/tissues related to Alopecia Universalis:

39
Skin, Thyroid, Pituitary, Liver, Bone, T Cells, Monocytes

Publications for Alopecia Universalis

Articles related to Alopecia Universalis:

(show top 50) (show all 145)
id Title Authors Year
1
Treatment of alopecia universalis with oral alitretinoin: A case report. ( 28349112 )
2017
2
Image Gallery: Treatment of refractory alopecia universalis with oral tofacitinib citrate and adjunct intralesional triamcinolone injections. ( 28581223 )
2017
3
Long-Term Prognosis of Alopecia Totalis and Alopecia Universalis: A Longitudinal Study with More than 10 Years of Follow-Up: Better than Reported. ( 28704810 )
2017
4
Successful hair regrowth in a Korean patient with alopecia universalis following tofacitinib treatment. ( 28536724 )
2017
5
Recovery of hair in the psoriatic plaques of a patient with coexistent alopecia universalis. ( 28492603 )
2017
6
Brazilian Experience of the Treatment of Alopecia Universalis with the Novel Antirheumatic Therapy Tofacitinib: A Case Series. ( 28755063 )
2017
7
Experience with oral tofacitinib in 8 adolescent patients with alopecia universalis. ( 28325392 )
2017
8
Pyridostigmine-Induced Bradycardia in Patient With MuSK-Ab-Positive Myasthenia Gravis and Alopecia Universalis. ( 28827491 )
2017
9
Review of treatment for alopecia totalis and alopecia universalis. ( 28378336 )
2017
10
Rare Presentation of Alopecia Universalis Congenita and Twenty-nail Dystrophy in Siblings. ( 28839389 )
2017
11
Efficacy of superficial cryotherapy on the eyebrows of patients with alopecia universalis also treated with contact immunotherapy on the scalp: a prospective, split-face comparative study. ( 28074525 )
2017
12
Excellent response to tofacitinib treatment in a patient with alopecia universalis. ( 28632888 )
2017
13
Alopecia universalis in a patient with Sheehan's syndrome. ( 26955590 )
2016
14
Topical Ruxolitinib for the Treatment of Alopecia Universalis. ( 26649829 )
2016
15
Alopecia universalis as a side effect of pegylated interferon I+-ribavirin combination therapy for hepatitis C: a rare case report. ( 27741937 )
2016
16
Efficacy of tofacitinib in treatment of alopecia universalis in two patients. ( 27306107 )
2016
17
Alopecia universalis in a dog with testicular neoplasia. ( 27644142 )
2016
18
Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated With Alopecia Universalis. ( 26630079 )
2016
19
Reversal of Alopecia Universalis by Tofacitinib: A Case Report. ( 27842401 )
2016
20
Hirschsprung's disease associated with alopecia universalis congenita: a case report. ( 27633379 )
2016
21
Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients. ( 27130559 )
2016
22
Case of alopecia universalis accompanied by minimal change nephrotic syndrome. ( 26300299 )
2015
23
Autoimmune Polyglandular Syndrome Type 2 with Alopecia Universalis and Hypoparathyroidism. ( 26591178 )
2015
24
Childhood follicular mucinosis co-existed with alopecia universalis. ( 25958720 )
2015
25
Biochemical and immunological studies on erythrocytes superoxide dismutase modified by nitric oxide in patients with alopecia areata: Implications in alopecia patchy persistent and alopecia universalis. ( 24694751 )
2014
26
Remission of long-standing alopecia universalis after human immunodeficiency virus infection. ( 24450742 )
2014
27
Ruxolitinib-Induced Reversal of Alopecia Universalis in a Patient with Essential Thrombocythemia. ( 25307179 )
2014
28
Alopecia Universalis Successfully Treated With Adalimumab. ( 25322338 )
2014
29
Sequential development of psoriasis, alopecia universalis, and vitiligo vulgaris in a human immunodeficiency virus seropositive patient: A unique case report. ( 26396459 )
2014
30
Alopecia universalis, renal stones, and hyperuricemia: a familial or an unfamiliar association. ( 24791244 )
2014
31
Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis. ( 24940651 )
2014
32
Alopecia universalis during treatment with leflunomide and adalimumab - case report. ( 24770511 )
2014
33
Alopecia universalis associated with cutaneous T cell lymphoma. ( 24821490 )
2014
34
Alopecia Universalis Associated with Vitiligo in an 18-year-old HIV-positive Patient: Highly Active Anti-retroviral Therapy as First Choice Therapy? ( 23824261 )
2014
35
Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report. ( 24558223 )
2014
36
Multicentric calcified trichilemmal cysts with alopecia universalis affecting siblings. ( 23254735 )
2013
37
Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis. ( 24019775 )
2013
38
Autoimmune polyglandular syndrome type 2, alopecia universalis and Crohn's disease. ( 22677116 )
2013
39
Alopecia universalis in polyglandular autoimmune syndrome type I. ( 24574702 )
2013
40
Satoyoshi syndrome: a cause of alopecia universalis in association with neurologic and bony abnormalities. ( 22612551 )
2013
41
Exomic sequencing of immune-related genes reveals novel candidate variants associated with alopecia universalis. ( 23326468 )
2013
42
A case of hypogonadism presented with alopecia universalis. ( 25207137 )
2013
43
Clinical characteristics and prognostic factors in early-onset alopecia totalis and alopecia universalis. ( 22787378 )
2012
44
A case of alopecia universalis with agminated lentiginosis and multiple cafAc-au-lait macules: a synchronous coincidence? ( 22182389 )
2012
45
Irreversible alopecia universalis during treatment with pegylated interferon-ribavirin for chronic hepatitis C virus infection: Case report and published work review. ( 23181541 )
2012
46
A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. ( 22116824 )
2012
47
Remission of alopecia universalis following successful clinical islet transplantation. ( 21951462 )
2011
48
Alopecia universalis following two sequential traffic accidents: possible association with increased Th1 and Th17 cells and decreased Th2 cells. ( 22259836 )
2011
49
Identification of a new mutation in the gene coding for hairless protein responsible for alopecia universalis: The importance of direct gene sequencing. ( 21272494 )
2011
50
Renbok phenomenon and contact sensitization in a patient with alopecia universalis. ( 20404233 )
2010

Variations for Alopecia Universalis

UniProtKB/Swiss-Prot genetic disease variations for Alopecia Universalis:

71
id Symbol AA change Variation ID SNP ID
1 HR p.Thr1022Ala VAR_005266 rs7014851
2 HR p.Val1136Asp VAR_005267 rs121434448
3 HR p.Asp1012Asn VAR_016222 rs121434451

ClinVar genetic disease variations for Alopecia Universalis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HR NM_005144.4(HR): c.3407T> A (p.Val1136Asp) single nucleotide variant Pathogenic rs121434448 GRCh37 Chromosome 8, 21973913: 21973913
2 HR HR, IVS12DS, G-A, +1 single nucleotide variant Pathogenic
3 HR NM_005144.4(HR): c.3034G> A (p.Asp1012Asn) single nucleotide variant Pathogenic rs121434451 GRCh37 Chromosome 8, 21976740: 21976740

Expression for Alopecia Universalis

Search GEO for disease gene expression data for Alopecia Universalis.

Pathways for Alopecia Universalis

Pathways related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 44)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 ICAM1 IFNG IL1A IL2RA TNF
2
Show member pathways
12.6 ICAM1 IFNG IL1A IL2RA TNF
3
Show member pathways
12.52 ICAM1 IFNG IL1A IL2RA TNF
4
Show member pathways
12.41 IFNG IL1A IL2RA TNF
5
Show member pathways
12.34 ICAM1 IFNG TNF
6
Show member pathways
12.26 IFNG IL1A TNF
7 12.25 ICAM1 IL2RA TNF
8
Show member pathways
12.1 IFNG IL1A TNF
9
Show member pathways
12.09 IFNG IL1A TNF
10 12.06 IFNG IL1A TNF
11
Show member pathways
12 IFNG IL1A TNF
12 11.89 IFNG IL1A TNF
13 11.84 IFNG IL2RA TNF
14 11.82 ICAM1 IL1A TNF
15 11.76 ICAM1 IL1A TNF
16 11.74 IL1A IL2RA TNF
17 11.7 ICAM1 IFNG IL1A TNF
18 11.64 IFNG IL2RA TNF
19
Show member pathways
11.6 IFNG IL2RA TNF
20 11.56 ICAM1 IL2RA TNF
21 11.54 ICAM1 IFNG IL1A TNF
22
Show member pathways
11.49 IFNG IL2RA TNF
23 11.38 ICAM1 IL1A TNF
24 11.37 ICAM1 TNF
25 11.37 IFNG TNF
26 11.37 IFNG TNF
27 11.36 ICAM1 IFNG TNF
28 11.35 IFNG IL2RA
29 11.32 ICAM1 IFNG
30 11.31 IFNG IL1A TNF
31 11.24 ICAM1 IFNG
32 11.21 IL1A TNF
33 11.21 ICAM1 IFNG IL1A TNF
34 11.18 IFNG IL2RA
35
Show member pathways
11.18 IFNG IL2RA TNF
36 11.16 IFNG TNF
37
Show member pathways
11.11 IFNG IL2RA
38 11.1 IFNG IL2RA
39 11.09 ICAM1 IFNG TNF
40 11.05 ICAM1 IFNG
41 10.97 IFNG IL1A TNF
42 10.92 IFNG IL1A
43 10.82 ICAM1 TNF
44
Show member pathways
10.72 ICAM1 IFNG IL1A TNF

GO Terms for Alopecia Universalis

Cellular components related to Alopecia Universalis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 ICAM1 IFNG IL2RA TNF

Biological processes related to Alopecia Universalis according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.61 ICAM1 IFNG TNF
2 positive regulation of interleukin-6 production GO:0032755 9.58 IL1A TNF
3 extrinsic apoptotic signaling pathway GO:0097191 9.57 IFNG TNF
4 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.56 IL1A TNF
5 positive regulation of cytokine secretion GO:0050715 9.55 IL1A TNF
6 protein import into nucleus, translocation GO:0000060 9.54 IFNG TNF
7 positive regulation of protein complex assembly GO:0031334 9.52 IFNG TNF
8 positive regulation of osteoclast differentiation GO:0045672 9.51 IFNG TNF
9 humoral immune response GO:0006959 9.5 AIRE IFNG TNF
10 response to copper ion GO:0046688 9.49 ICAM1 IL1A
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.48 IFNG TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.46 IFNG TNF
13 positive regulation of chemokine biosynthetic process GO:0045080 9.4 IFNG TNF
14 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.37 ICAM1 TNF
15 immune response GO:0006955 9.35 AIRE IFNG IL1A IL2RA TNF
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.33 ICAM1 IFNG TNF
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IFNG TNF
18 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF

Molecular functions related to Alopecia Universalis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IFNG IL1A TNF

Sources for Alopecia Universalis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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