MCID: ALV002
MIFTS: 67

Alveolar Echinococcosis malady

Rare diseases, Infectious diseases categories

Summaries for Alveolar Echinococcosis

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Disease Ontology:10 An echinococcosis that is caused by the larvae of echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary: Alveolar Echinococcosis, also known as echinococcosis, is related to echinococcosis and hepatitis, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Alveolar Echinococcosis is MT-CO1 (mitochondrially encoded cytochrome c oxidase I), and among its related pathways are Primary immunodeficiency and IL12 signaling mediated by STAT4. The drug albendazole and the compounds solium and dr-10 have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Alveolar Echinococcosis

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 62UMLS, 57SNOMED-CT, 29ICD9CM, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Alveolar Echinococcosis, Aliases & Descriptions:

Name: Alveolar Echinococcosis 10 43 49 62
Echinococcosis 43 62
Multilocular Hydatid 10
 
Small Fox Tapeworm 10
Alveolococcosis 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

49
alveolar echinococcosis:
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly


External Ids:

Disease Ontology10 DOID:12148
ICD9CM29 122.7
Orphanet49 284
SNOMED-CT57 240816000, 21009004
MESH via Orphanet36 C536591
ICD10 via Orphanet28 B67.5, B67.6, B67.7
UMLS via Orphanet63 C0948954

Related Diseases for Alveolar Echinococcosis

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Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis32.3MT-CO1
2hepatitis31.5HLA-DRB1, HLA-A, TAP2
3hepatocellular carcinoma30.2TAP1, HLA-A, HLA-DRB1, KLRK1, TAP2
4arthritis30.1TNF, HLA-DRB1, HLA-C, HLA-A, HLA-B, IFNG
5thyroiditis30.0HLA-C, HLA-DRB1
6rheumatoid arthritis30.0TNF, TSPAN32, IFNG, IL10, KLRK1, TAP2
7pneumonia29.9IL10, TNF
8hiv-129.9HLA-B, HLA-A, HLA-C
9schistosomiasis29.9IL10, IFNG, TSPAN32
10tuberculosis29.8HLA-DQB1, IL10, KLRK1, HLA-A, IFNG, TNF
11cerebritis10.7
12cysticercosis10.6
13polycystic echinococcosis10.6
14taeniasis10.5
15budd-chiari syndrome10.5
16cystic echinococcosis10.2
17parametritis10.2
18acquired immunodeficiency syndrome10.2
19mediastinitis10.2
20pancreatitis10.2
21peritonitis10.2
22prostatitis10.2
23pulmonary embolism10.2
24hypoxia10.2
25blindness10.2
26toxocariasis10.1
27leprosy10.1HLA-DRB1
28aphthous stomatitis10.1HLA-B
29blau syndrome10.0TNF
30narcolepsy10.0HLA-DRB1
31reactive arthritis10.0TAP2, HLA-B
32multiple sclerosis, disease progression, modifier of10.0HLA-DQB1, HLA-DRB1
33bare lymphocyte syndrome, type ii, complementation group c10.0HLA-A, TAP2
34human immunodeficiency virus infectious disease10.0HLA-C, HLA-A
35celiac disease10.0HLA-A, HLA-DQB1, KLRK1
36cholangitis, primary sclerosing10.0HLA-C, HLA-A
37familial mediterranean fever, ar10.0HLA-A, TNF
38schizophrenia10.0HLA-DRB1, HLA-DQB1, TAP1
39hypersensitivity syndrome, carbamazepine-induced10.0HLA-B, HLA-A, HLA-C
40alcoholic hepatitis10.0IL10, TNF
41cervical cancer, somatic10.0TAP1, HLA-A, TAP2
42juvenile rheumatoid arthritis10.0HLA-DRB1, TNF, HLA-DQB1
43autoimmune hepatitis10.0HLA-A, HLA-DRB1, HLA-DQB1
44myeloma10.0HLA-B, KLRK1, TSPAN32, CD36
45psoriatic arthritis10.0HLA-C, TNF
46small cell cancer of the lung, somatic10.0TAP1, TSPAN32, TAP2
47nasopharyngeal carcinoma10.0KLRK1, TAP1, HLA-B, HLA-A
48spondyloarthropathy 110.0TNF, TAP1, HLA-B, TAP2
49colorectal cancer10.0HLA-A, TAP1, KLRK1, TAP2
50leishmaniasis10.0IL10, IFNG

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to alveolar echinococcosis

Symptoms for Alveolar Echinococcosis

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Symptoms:

 49 (show all 45)
  • pruritus/itching
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • polycystic liver disease/hepatic cysts
  • hepatitis/icterus/cholestasis
  • extrahepatic biliary tract atresia/obstruction
  • hepatomegaly/liver enlargement (excluding storage disease)
  • anaemia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • visual loss/blindness/amblyopia
  • anomalies of spine, vertebrae and pelvis
  • anomalies of skin, subcutaneous tissue and mucosae
  • ascitis
  • esophageal varices
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • peritonitis/peritoneal abscess
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • cirrhosis
  • chronic hepatic failure
  • portal hypertension
  • splenomegaly
  • lung/pulmonary infiltrates
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • abnormal/polycystic ovaries
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • transient cerebral ischemia/stroke
  • cranial hypertension
  • ataxia/incoordination/trouble of the equilibrium
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • elocution disorders/dysarthria/dysphonia
  • muscle anomalies
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone cyst
  • severe allergic reaction/atopy
  • benign tumor of the brain/nervous system
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Alveolar Echinococcosis:

(show all 38)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 weight loss typical (50%) HP:0001824
6 anemia typical (50%) HP:0001903
7 hepatomegaly typical (50%) HP:0002240
8 abnormality of temperature regulation typical (50%) HP:0004370
9 extrahepatic biliary duct atresia typical (50%) HP:0005242
10 polycystic ovaries occasional (7.5%) HP:0000147
11 visual impairment occasional (7.5%) HP:0000505
12 seizures occasional (7.5%) HP:0001250
13 cirrhosis occasional (7.5%) HP:0001394
14 portal hypertension occasional (7.5%) HP:0001409
15 ascites occasional (7.5%) HP:0001541
16 splenomegaly occasional (7.5%) HP:0001744
17 esophageal varix occasional (7.5%) HP:0002040
18 migraine occasional (7.5%) HP:0002076
19 respiratory insufficiency occasional (7.5%) HP:0002093
20 hemoptysis occasional (7.5%) HP:0002105
21 pulmonary infiltrates occasional (7.5%) HP:0002113
22 neurological speech impairment occasional (7.5%) HP:0002167
23 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
24 incoordination occasional (7.5%) HP:0002311
25 increased intracranial pressure occasional (7.5%) HP:0002516
26 peritonitis occasional (7.5%) HP:0002586
27 cerebral ischemia occasional (7.5%) HP:0002637
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 paresthesia occasional (7.5%) HP:0003401
31 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 chronic hepatic failure occasional (7.5%) HP:0100626
36 chest pain occasional (7.5%) HP:0100749
37 sepsis occasional (7.5%) HP:0100806
38 benign neoplasm of the central nervous system occasional (7.5%) HP:0100835

Drugs & Therapeutics for Alveolar Echinococcosis

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Drug clinical trials:

Search ClinicalTrials for Alveolar Echinococcosis

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Alveolar Echinococcosis

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Anatomical Context for Alveolar Echinococcosis

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MalaCards organs/tissues related to Alveolar Echinococcosis:

33
Liver, Lung, Brain, Bone, Ovary, Skin, Testes, Pancreas, Adrenal gland, T cells, Spleen, Spinal cord, Breast, Prostate, Testis

Animal Models for Alveolar Echinococcosis or affiliated genes

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MGI Mouse Phenotypes related to Alveolar Echinococcosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9IL10, KLRK1, TAP1, TNF, IFNG
2MP:00053817.7TNF, IFNG, IL10, CD36, HLA-DQB1
3MP:00053697.5IFNG, HLA-DQB1, TNF, MT-CO1, CD36, IL10
4MP:00053707.4CD36, IL10, TNF, IFNG, HLA-DQB1
5MP:00036317.0HLA-DQB1, TNF, IFNG, IL10, TAP1, CD8A
6MP:00107686.7HLA-DQB1, CD36, CD8A, TAP1, KLRK1, IL10
7MP:00053976.0CD36, CD8A, TAP2, TAP1, KLRK1, HLA-B
8MP:00053875.8HLA-B, CD36, CD8A, TAP2, TAP1, HLA-DQB1

Publications for Alveolar Echinococcosis

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Articles related to Alveolar Echinococcosis:

(show top 50)    (show all 371)
idTitleAuthorsYear
1
Unique MRI findings for differentiation of an early stage of hepatic alveolar echinococcosis. (25697300)
2015
2
Two other hepatic cystic lesions: alveolar echinococcosis and intraductal papillary mucinous tumor of the bile ducts. (25905974)
2015
3
Comparison of the serological tests ICT and ELISA for the diagnosis of alveolar echinococcosis in Francea98. (25058754)
2014
4
Immunodiagnosis of alveolar echinococcosis using urine samples. (23872436)
2013
5
PRIMARY CEREBRAL ALVEOLAR ECHINOCOCCOSIS: MYCOLOGY TO THE RESCUE. (24335950)
2013
6
Alveolar echinococcosis of the adrenal gland: brief review of two cases. (22800838)
2012
7
An uncommon reason for dyspnoea: phrenic paresis secondary to alveolar echinococcosis. (23024329)
2012
8
Parasite-specific IL-17-type cytokine responses and soluble IL-17 receptor levels in Alveolar Echinococcosis patients. (22969818)
2012
9
Alveolar echinococcosis: spectrum of findings at cross-sectional imaging. (23150858)
2012
10
Immunochromatographic test with recombinant Em18 antigen for the follow-up study of alveolar echinococcosis. (21715578)
2011
11
Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china. (20042519)
2010
12
Dot immunogold filtration assay (DIGFA) with multiple native antigens for rapid serodiagnosis of human cystic and alveolar echinococcosis. (19836341)
2010
13
Education and Imaging. Hepatobiliary and pancreatic: alveolar echinococcosis mimicking hepatocellular carcinoma. (20928949)
2010
14
Skin fistulization associated with extensive alveolar echinococcosis. (20406585)
2010
15
Pitfall alveolar echinococcosis in non-endemic areas. Alveolar echinococcosis migrating northward. (20308731)
2010
16
Giant hepatic alveolar echinococcosis in an adult. (19427628)
2009
17
Research on targeting sources of alveolar echinococcosis in Japan. (17662388)
2007
18
Human alveolar echinococcosis in Slovenia. (17371540)
2007
19
Stereological evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis using computed tomography via the Cavalieri method. (17105589)
2006
20
Socioeconomic and behavior risk factors of human alveolar echinococcosis in Tibetan communities in Sichuan, People's Republic of China. (16687693)
2006
21
Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients. (16879243)
2006
22
Alveolar echinococcosis in the zoological garden Basle. (16315852)
2005
23
Orthotopic liver transplantation for incurable alveolar echinococcosis: report of five cases from west China. (15964373)
2005
24
Secondary and primary murine alveolar echinococcosis: combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity. (15064126)
2004
25
Mediastinal recurrence of alveolar echinococcosis after liver transplantation. (12514779)
2003
26
HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China. (14570623)
2003
27
European echinococcosis registry: human alveolar echinococcosis, Europe, 1982-2000. (12643830)
2003
28
Development of Em18-immunoblot and Em18-ELISA for specific diagnosis of alveolar echinococcosis. (12606094)
2003
29
Evaluation of use of recombinant Em18 and affinity-purified Em18 for serological differentiation of alveolar echinococcosis from cystic echinococcosis and other parasitic infections. (12843091)
2003
30
Alveolar echinococcosis in Turkey. Experience from an endemic region. (12789026)
2003
31
Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: results of a blind test. (12409391)
2002
32
Molecular tools for the diagnosis of cystic and alveolar echinococcosis. (11422961)
2001
33
Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature. (10980173)
2000
34
Extrahepatic alveolar echinococcosis without liver involvement: a rare manifestation. (10879649)
2000
35
Hepatic alveolar echinococcosis. A case report. (10335973)
1999
36
Primary disease recurrence after liver transplantation for alveolar echinococcosis: long-term evaluation in 15 patients. (10498634)
1999
37
Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis. (9875648)
1998
38
Cystic and alveolar echinococcosis in Turkey. (9924542)
1998
39
Imaging diagnosis of alveolar echinococcosis in young patients. (8995172)
1997
40
Epidemiology of alveolar echinococcosis in southern Germany (Bavaria). (7622269)
1995
41
Human alveolar echinococcosis seroprevalence assessed by western blotting in Hokkaido. (8531411)
1995
42
Association between HLA-DR13 and susceptibility to alveolar echinococcosis. (8195634)
1994
43
CT in lobar atrophy of the liver caused by alveolar echinococcosis. (1545016)
1992
44
Growing importance of prevention and control of alveolar echinococcosis. (1953939)
1991
45
Application of a recombinant Echinococcus multilocularis antigen in an enzyme-linked immunosorbent assay for immunodiagnosis of human alveolar echinococcosis. (2671725)
1989
46
Orthotopic liver transplantation in alveolar echinococcosis of the liver: analysis of a series of six patients. (2450418)
1988
47
An international study on the serological differential diagnosis of human cystic and alveolar echinococcosis. (3488132)
1986
48
Experimental alveolar echinococcosis. Suitability of a murine model of intrahepatic infection by Echinococcus multilocularis for immunological studies. (6510502)
1984
49
Hepatic alveolar echinococcosis invading pancreas, vertebrae, and spinal cord. (7129411)
1982
50
Immunomorphology and pathogenesis of echinococcosis. III: Microscopic immunofluorescence studies in experimental alveolar echinococcosis. (344225)
1978

Variations for Alveolar Echinococcosis

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Expression for genes affiliated with Alveolar Echinococcosis

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Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for genes affiliated with Alveolar Echinococcosis

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Pathways related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TAP2, CD8A, TAP1
29.5HLA-DRB1, IFNG
3
Show member pathways
9.5HLA-DQB1, HLA-DRB5, HLA-DRB1
4
Show member pathways
9.5HLA-DRB5, HLA-DRB1, HLA-DQB1
59.5HLA-DQB1, HLA-DRB5, HLA-DRB1
6
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.5HLA-DQB1, HLA-DRB5, HLA-DRB1
7
Show member pathways
9.5HLA-DQB1, HLA-DRB1, HLA-DRB5
8
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.5HLA-DRB1, HLA-DRB5, HLA-DQB1
9
Show member pathways
TCR signaling in naive CD8+ T cells38
9.5HLA-DRB1, HLA-A, CD8A
109.4HLA-C, HLA-A, HLA-B
11
Show member pathways
9.4HLA-A, HLA-C, HLA-B
129.3IL10, IFNG
13
Show member pathways
9.3HLA-DRB5, CD8A, HLA-DQB1, HLA-DRB1
14
Show member pathways
9.3HLA-DRB5, CD8A, HLA-DQB1, HLA-DRB1
159.3HLA-B, TAP1, IFNG
169.2CD36, TNF
179.2IL10, TAP2, CD8A, TAP1
189.0IFNG, TNF
199.0HLA-DQB1, IL10, HLA-DRB5, HLA-DRB1
208.9HLA-B, HLA-A, KLRK1, HLA-C, CD8A
21
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.8HLA-A, HLA-DRB1, CD8A, IFNG
22
Show member pathways
8.8HLA-B, HLA-A, TAP1, TAP2, HLA-C
23
Show member pathways
IL27-mediated signaling events38
8.5TNF, IL10, IFNG
24
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.5TNF, IFNG, IL10
258.5TNF, IFNG, IL10
268.5TNF, IFNG, IL10
278.5IFNG, IL10, TNF
28
Show member pathways
8.5IFNG, IL10, TNF
298.4HLA-DRB1, HLA-DRB5, CD36, CD8A, TNF
30
Show member pathways
8.4HLA-A, HLA-DQB1, HLA-DRB5, HLA-DRB1, HLA-C, HLA-B
31
Show member pathways
Ras signaling in the CD4+ TCR pathway38
8.3CD8A, IFNG, TNF, HLA-A
32
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.3TNF, CD8A, IL10, IFNG
33
Show member pathways
8.2TNF, HLA-DRB5, HLA-C, HLA-DQB1, HLA-A
348.2HLA-DRB5, HLA-B, CD8A, HLA-DRB1, HLA-A, HLA-DQB1
358.2IFNG, IL10, TNF, HLA-DRB1
36
Show member pathways
8.1IFNG, TNF, HLA-DRB1, HLA-DRB5, HLA-DQB1
378.1HLA-DRB1, TNF, HLA-DQB1, HLA-DRB5, IFNG
387.9IFNG, IL10, KLRK1, CD36, TNF
39
Show member pathways
7.8HLA-A, HLA-DQB1, IFNG, HLA-C, HLA-DRB5, HLA-DRB1
40
Show member pathways
Immune response CD16 signaling in NK cells60
7.7KLRK1, IFNG, HLA-B, TNF, HLA-C, HLA-A
417.6HLA-B, HLA-A, HLA-DQB1, HLA-DRB5, HLA-DRB1, TNF
42
Show member pathways
7.6HLA-DRB1, TNF, IFNG, IL10, HLA-DRB5, HLA-DQB1
43
Show member pathways
7.6IFNG, TNF, HLA-DRB1, HLA-DQB1, IL10, HLA-DRB5
447.6IFNG, IL10, HLA-DQB1, HLA-DRB5, HLA-DRB1, TNF
457.5CD36, HLA-A, HLA-B, HLA-DQB1, HLA-C, HLA-DRB5
467.3HLA-DRB5, IL10, HLA-DQB1, HLA-DRB1, IFNG, HLA-A
47
Show member pathways
7.0TAP1, HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
48
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
6.7CD36, TNF, TAP2, HLA-B, TAP1, IFNG
49
Show member pathways
6.4HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1, TNF
50
Show member pathways
5.7HLA-DQB1, IFNG, HLA-A, CD8A, TAP2, TAP1

Compounds for genes affiliated with Alveolar Echinococcosis

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Compounds related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1solium4510.2HLA-B, MT-CO1
2dr-104510.1HLA-A, HLA-DRB1
3betaseron459.6IFNG, IL10
4glatiramer acetate45 1310.4IL10, HLA-DRB1, IFNG
5cdp571459.3IL10, TNF
6ribavirin45 51 1311.3HLA-B, IFNG, IL10
7ifn-alpha459.3IFNG, TAP1, IL10
8alpha-galactosylceramide459.2IL10, IFNG
9lipoteichoic acid459.2TNF, HLA-B, IL10
10gold sodium thiomalate459.1TNF, HLA-DRB1, IFNG
11allergens459.1IL10, IFNG, HLA-DRB1
12abacavir51 45 1311.1TNF, HLA-B
13taurine chloramine459.0IFNG, TNF
14budesonide45 51 1311.0IFNG, TNF, CD36
15glucosamine45 26 1311.0TNF, IFNG, CD36
16interferon gamma459.0IL10, IFNG, TNF
17natalizumab45 139.9TNF, IFNG, IL10
18il-12458.9IL10, IFNG, TNF
19adalimumab45 51 1310.9TNF, IFNG, IL10
20carbamazepine45 51 1310.9HLA-B, CD36, TNF, HLA-A
21indoleamine458.9IL10, TNF, IFNG
22imiquimod45 61 30 1311.9TNF, IL10, IFNG
23polymyxin b458.9IL10, TNF, IFNG
24okt3458.9TNF, IL10, IFNG
25oligonucleotide458.9HLA-DQB1, HLA-A, HLA-B, TAP2, TAP1, HLA-DRB1
26gm-csf45 309.9IFNG, TNF, IL10
27rolipram45 61 3010.9IL10, TNF, IFNG
28etanercept45 51 1310.9TNF, IFNG, IL10
29infliximab45 51 1310.8IL10, IFNG, TNF
30tarc458.8TNF, IFNG, IL10
31ivig458.8IL10, TNF, IFNG
32pentoxifylline45 139.8IFNG, IL10, TNF
33ccl345 309.8IL10, IFNG, TNF
34il 10458.7IFNG, IL10, CD8A, TNF
35neopterin458.7IL10, TNF, IFNG
362,5-oligoadenylate458.7IFNG, HLA-B, TNF, IL10
37endotoxin458.6HLA-B, TNF, IL10, IFNG
38mycophenolate mofetil45 51 1310.5IFNG, IL10, TNF, CD36
3915-deoxy-delta-12,14-prostaglandin j2458.5IL10, CD36, TNF, IFNG
40arginine458.5HLA-A, HLA-B, HLA-DRB1, IFNG, KLRK1
41thalidomide45 51 61 1311.5IL10, IFNG, TNF, CD36
42rantes458.5IFNG, TNF, IL10, HLA-B
43hydrocortisone45 3 61 1311.5TNF, IFNG, CD36, IL10
44calcitriol45 61 26 1311.5IL10, TNF, CD36, IFNG
45polyinosinic-polycytidylic acid458.4HLA-B, KLRK1, IL10, IFNG, TNF
46sb 20358045 619.3CD36, IL10, IFNG, TNF
47pge2458.2IL10, CD36, HLA-B, TNF, IFNG
48cyclosporin a45 30 6110.1HLA-B, TNF, IFNG, IL10, HLA-A
49dexamethasone45 51 30 1310.9IL10, IFNG, TNF, HLA-B, CD36
50tacrolimus45 51 139.8TNF, CD36, HLA-A, IFNG, HLA-B, IL10

GO Terms for genes affiliated with Alveolar Echinococcosis

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Cellular components related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.7HLA-DRB5, HLA-DRB1, HLA-DQB1
2clathrin-coated endocytic vesicle membraneGO:00306699.6HLA-DRB1, HLA-DRB5, HLA-DQB1
3TAP complexGO:00428259.6TAP2, TAP1
4MHC class I protein complexGO:00426129.6HLA-B, HLA-A, HLA-C
5transport vesicle membraneGO:00306589.6HLA-DQB1, HLA-DRB5, HLA-DRB1
6trans-Golgi network membraneGO:00325889.5HLA-DQB1, HLA-DRB5, HLA-DRB1
7early endosome membraneGO:00319019.4HLA-C, HLA-B, HLA-A
8endocytic vesicle membraneGO:00306669.4CD36, HLA-DRB5, HLA-DQB1, HLA-DRB1
9phagocytic vesicle membraneGO:00306709.3HLA-C, HLA-A, HLA-B
10integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.7HLA-DRB1, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-B
11ER to Golgi transport vesicle membraneGO:00125078.7HLA-B, HLA-DRB5, HLA-C, HLA-DQB1, HLA-A, HLA-DRB1
12Golgi membraneGO:00001398.6HLA-C, HLA-DRB5, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
13external side of plasma membraneGO:00098978.1TNF, CD8A, HLA-DRB5, IFNG, CD36, HLA-DRB1
14cell surfaceGO:00099867.9TNF, HLA-C, CD36, HLA-A, TSPAN32, HLA-B
15integral component of plasma membraneGO:00058877.7HLA-DRB1, TNF, CD8A, CD36, HLA-B, HLA-A
16plasma membraneGO:00058866.7TAP1, CD36, CD8A, TAP2, TNF, HLA-DRB1

Biological processes related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:004696710.3TAP2, TAP1
2oligopeptide transmembrane transportGO:003567210.3TAP2, TAP1
3intracellular transport of viral protein in host cellGO:001906010.3TAP1, TAP2
4regulation of interleukin-10 secretionGO:0200117910.3HLA-DRB1, HLA-DRB5
5antigen processing and presentation of endogenous peptide antigen via MHC class IGO:001988510.3TAP2, TAP1
6regulation of interleukin-4 productionGO:003267310.3HLA-DRB1, HLA-DRB5
7peptide transportGO:001583310.2TAP1, TAP2
8T-helper 1 type immune responseGO:004208810.2HLA-DRB5, HLA-DRB1
9inflammatory response to antigenic stimulusGO:000243710.1HLA-DRB5, HLA-DRB1
10positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:003577410.1HLA-DRB1, HLA-DRB5
11immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.9HLA-DQB1, HLA-DRB1, HLA-DRB5
12humoral immune response mediated by circulating immunoglobulinGO:00024559.9HLA-DQB1, HLA-DRB1, HLA-DRB5
13T cell costimulationGO:00312959.9HLA-DRB5, HLA-DQB1, HLA-DRB1
14T cell receptor signaling pathwayGO:00508529.8HLA-DRB5, HLA-DRB1, HLA-DQB1
15negative regulation of myeloid dendritic cell activationGO:00308869.8TSPAN32, IL10
16antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.8HLA-DQB1, HLA-DRB5, HLA-DRB1
17antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:00024869.8HLA-A, HLA-C, HLA-B
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00024809.8HLA-C, HLA-B, HLA-A
19negative regulation of interferon-gamma productionGO:00326899.8HLA-DRB5, HLA-DRB1, IL10
20negative regulation of T cell proliferationGO:00421309.8HLA-DRB1, IL10, HLA-DRB5
21type I interferon signaling pathwayGO:00603379.7HLA-B, HLA-C, HLA-A
22positive regulation of MHC class II biosynthetic processGO:00453489.6IFNG, IL10
23protein tetramerizationGO:00512629.6HLA-DRB1, HLA-DRB5
24detection of bacteriumGO:00160459.6HLA-B, HLA-A, HLA-DRB5, HLA-DRB1
25regulation of immune responseGO:00507769.6CD8A, HLA-A, HLA-C, HLA-B
26defense response to protozoanGO:00428329.5IFNG, TSPAN32
27receptor biosynthetic processGO:00328009.5TNF, IL10
28positive regulation of interleukin-12 productionGO:00327359.5CD36, IFNG
29negative regulation of cytokine secretion involved in immune responseGO:00027409.5TNF, IL10
30positive regulation of vitamin D biosynthetic processGO:00605579.4TNF, IFNG
31positive regulation of calcidiol 1-monooxygenase activityGO:00605599.4TNF, IFNG
32positive regulation of chemokine biosynthetic processGO:00450809.3IFNG, TNF
33positive regulation of membrane protein ectodomain proteolysisGO:00510449.3TNF, IFNG
34negative regulation of interleukin-6 productionGO:00327159.3IL10, TNF
35positive regulation of T cell mediated cytotoxicityGO:00019169.3HLA-C, HLA-B, HLA-A, TAP2, TAP1
36cellular response to lipopolysaccharideGO:00712229.3IL10, IFNG, CD36
37positive regulation of osteoclast differentiationGO:00456729.2TNF, IFNG
38protein import into nucleus, translocationGO:00000609.1TNF, IFNG
39positive regulation of cytokine secretionGO:00507159.1TNF, IL10
40response to activityGO:00148239.0IL10, TNF
41positive regulation of nitric oxide biosynthetic processGO:00454299.0IFNG, TNF
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00024798.9TAP1, TAP2, HLA-B, HLA-A, CD36, HLA-C
43antigen processing and presentation of exogenous peptide antigen via MHC class IGO:00425908.9HLA-B, HLA-A, HLA-C, TAP1, TAP2, CD36
44antigen processing and presentation of peptide antigen via MHC class IGO:00024748.9TAP1, HLA-A, HLA-B, CD36, HLA-C, TAP2
45immune responseGO:00069558.6HLA-DRB5, CD8A, HLA-DRB1, HLA-B, HLA-A, HLA-DQB1
46negative regulation of growth of symbiont in hostGO:00441308.5TNF, IFNG, IL10, CD36
47interferon-gamma-mediated signaling pathwayGO:00603338.2HLA-DRB1, HLA-C, HLA-DQB1, HLA-DRB5, IFNG, HLA-A
48cytokine-mediated signaling pathwayGO:00192218.2HLA-DQB1, HLA-B, HLA-A, HLA-DRB1, HLA-DRB5, HLA-C

Molecular functions related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:004698010.1TAP2, TAP1
2peptide transporter activityGO:001519710.1TAP2, TAP1
3MHC class Ib protein bindingGO:002302910.0TAP1, TAP2
4oligopeptide-transporting ATPase activityGO:001542110.0TAP2, TAP1
5TAP2 bindingGO:00469799.9TAP1, TAP2
6MHC class I protein bindingGO:00422889.9CD8A, TAP2, TAP1
7TAP1 bindingGO:00469789.8TAP1, TAP2
8TAP bindingGO:00469779.6HLA-C, HLA-A, HLA-B
9MHC class II receptor activityGO:00323959.5HLA-DQB1, HLA-DRB1
10cytokine activityGO:00051258.5TNF, IFNG, IL10
11peptide antigen bindingGO:00426058.5TAP1, HLA-DRB1, HLA-DRB5, HLA-C, HLA-A, HLA-B

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