MCID: ALV002
MIFTS: 68

Alveolar Echinococcosis malady

Rare diseases, Infectious diseases categories
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Summaries for Alveolar Echinococcosis

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Disease Ontology:8 An echinococcosis that is caused by the larvae of echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary: Alveolar Echinococcosis, also known as echinococcosis, is related to echinococcosis and hepatitis, and has symptoms including pruritus/itching, nausea/vomiting/regurgitation/merycism/hyperemesis and acute abdominal pain/colic. An important gene associated with Alveolar Echinococcosis is MT-CO1 (mitochondrially encoded cytochrome c oxidase I), and among its related pathways are Primary immunodeficiency and IL12 signaling mediated by STAT4. The drug albendazole and the compounds solium and dr-10 have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:65 Alveolar hydatid disease (AHD), also known as alveolar echinococcosis, alveolar colloid of the liver,... more...

Aliases & Classifications for Alveolar Echinococcosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 57SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Alveolar Echinococcosis, Aliases & Descriptions:

Name: Alveolar Echinococcosis 8 42 48 62
Echinococcosis 42 62
Multilocular Hydatid 8
 
Small Fox Tapeworm 8
Alveolococcosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
alveolar echinococcosis:
Age of onset: Adulthood; Age of death: Adult


External Ids:

Disease Ontology8 DOID:12148
ICD9CM27 122.7
MESH via Orphanet35 C536591
SNOMED-CT57 21009004, 240816000
ICD10 via Orphanet26 B67.5, B67.6, B67.7
UMLS via Orphanet63 C0948954

Related Diseases for Alveolar Echinococcosis

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Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis33.1MT-CO1
2hepatitis31.7HLA-DRB1, HLA-A, TAP2
3thyroiditis30.4HLA-C, HLA-DRB1
4pneumonia30.0IL10, TNF
5schistosomiasis29.8IL10, IFNG, TSPAN32
6arthritis28.8TNF, HLA-DRB1, HLA-C, HLA-A, HLA-B, IFNG
7tuberculosis28.7HLA-DQB1, IL10, KLRK1, HLA-A, IFNG, TNF
8rheumatoid arthritis28.2TNF, TSPAN32, IFNG, IL10, KLRK1, TAP2
9cerebritis10.7
10cysticercosis10.6
11polycystic echinococcosis10.6
12leprosy10.5HLA-DRB1
13aphthous stomatitis10.5HLA-B
14taeniasis10.5
15blau syndrome10.4TNF
16narcolepsy10.3HLA-DRB1
17reactive arthritis10.3TAP2, HLA-B
18multiple sclerosis 110.3HLA-DQB1, HLA-DRB1
19cystic echinococcosis10.3
20bare lymphocyte syndrome10.3HLA-A, TAP2
21human immunodeficiency virus infectious disease10.2HLA-C, HLA-A
22hepatocellular carcinoma10.2
23acquired immunodeficiency syndrome10.2
24mediastinitis10.2
25pancreatitis10.2
26peritonitis10.2
27prostatitis10.2
28pulmonary embolism10.2
29blindness10.2
30celiac disease10.2HLA-A, HLA-DQB1, KLRK1
31primary sclerosing cholangitis10.1HLA-C, HLA-A
32familial mediterranean fever10.1HLA-A, TNF
33schizophrenia10.1HLA-DRB1, HLA-DQB1, TAP1
34stevens-johnson syndrome10.1HLA-B, HLA-A, HLA-C
35alcoholic hepatitis10.1IL10, TNF
36toxocariasis10.1
37juvenile rheumatoid arthritis10.1HLA-DRB1, TNF, HLA-DQB1
38cervical cancer10.1TAP1, HLA-A, TAP2
39autoimmune hepatitis10.1HLA-A, HLA-DRB1, HLA-DQB1
40myeloma10.1HLA-B, KLRK1, TSPAN32, CD36
41nasopharynx carcinoma10.1KLRK1, TAP1, HLA-B, HLA-A
42ankylosing spondylitis10.1TNF, TAP1, HLA-B, TAP2
43colorectal cancer10.0HLA-A, TAP1, KLRK1, TAP2
44psoriatic arthritis10.0HLA-C, TNF
45leishmaniasis10.0IL10, IFNG
46tuberculoid leprosy10.0IL10, IFNG
47lepromatous leprosy10.0IL10, IFNG
48lung small cell carcinoma10.0TAP1, TSPAN32, TAP2
49visceral leishmaniasis10.0IFNG, IL10
50cutaneous leishmaniasis10.0IL10, IFNG

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to alveolar echinococcosis

Symptoms for Alveolar Echinococcosis

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Symptoms:

48 (show all 45)
  • pruritus/itching
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • polycystic liver disease/hepatic cysts
  • hepatitis/icterus/cholestasis
  • extrahepatic biliary tract atresia/obstruction
  • hepatomegaly/liver enlargement (excluding storage disease)
  • anaemia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • visual loss/blindness/amblyopia
  • anomalies of spine, vertebrae and pelvis
  • anomalies of skin, subcutaneous tissue and mucosae
  • ascitis
  • esophageal varices
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • peritonitis/peritoneal abscess
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • cirrhosis
  • chronic hepatic failure
  • portal hypertension
  • splenomegaly
  • lung/pulmonary infiltrates
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • abnormal/polycystic ovaries
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • transient cerebral ischemia/stroke
  • cranial hypertension
  • ataxia/incoordination/trouble of the equilibrium
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • elocution disorders/dysarthria/dysphonia
  • muscle anomalies
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone cyst
  • severe allergic reaction/atopy
  • benign tumor of the brain/nervous system
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Alveolar Echinococcosis:

(show all 38)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 weight loss typical (50%) HP:0001824
6 anemia typical (50%) HP:0001903
7 hepatomegaly typical (50%) HP:0002240
8 abnormality of temperature regulation typical (50%) HP:0004370
9 extrahepatic biliary duct atresia typical (50%) HP:0005242
10 polycystic ovaries occasional (7.5%) HP:0000147
11 visual impairment occasional (7.5%) HP:0000505
12 seizures occasional (7.5%) HP:0001250
13 cirrhosis occasional (7.5%) HP:0001394
14 portal hypertension occasional (7.5%) HP:0001409
15 ascites occasional (7.5%) HP:0001541
16 splenomegaly occasional (7.5%) HP:0001744
17 esophageal varix occasional (7.5%) HP:0002040
18 migraine occasional (7.5%) HP:0002076
19 respiratory insufficiency occasional (7.5%) HP:0002093
20 hemoptysis occasional (7.5%) HP:0002105
21 pulmonary infiltrates occasional (7.5%) HP:0002113
22 neurological speech impairment occasional (7.5%) HP:0002167
23 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
24 incoordination occasional (7.5%) HP:0002311
25 increased intracranial pressure occasional (7.5%) HP:0002516
26 peritonitis occasional (7.5%) HP:0002586
27 cerebral ischemia occasional (7.5%) HP:0002637
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 paresthesia occasional (7.5%) HP:0003401
31 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 chronic hepatic failure occasional (7.5%) HP:0100626
36 chest pain occasional (7.5%) HP:0100749
37 sepsis occasional (7.5%) HP:0100806
38 benign neoplasm of the central nervous system occasional (7.5%) HP:0100835

Drugs & Therapeutics for Alveolar Echinococcosis

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Drug clinical trials:

Search ClinicalTrials for Alveolar Echinococcosis

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Alveolar Echinococcosis

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Anatomical Context for Alveolar Echinococcosis

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MalaCards organs/tissues related to Alveolar Echinococcosis:

32
Liver, Lung, Brain, Bone, Skin, Testes, Ovary, Pancreas, Adrenal gland, T cells, Spleen, Spinal cord, Breast, Prostate, Testis

Animal Models for Alveolar Echinococcosis or affiliated genes

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MGI Mouse Phenotypes related to Alveolar Echinococcosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9TNF, IFNG, IL10, KLRK1, TAP1
2MP:00053817.7CD36, IL10, IFNG, TNF, HLA-DQB1
3MP:00053697.5HLA-DQB1, TNF, MT-CO1, IFNG, IL10, CD36
4MP:00053707.4HLA-DQB1, TNF, IFNG, IL10, CD36
5MP:00036317.0HLA-B, HLA-DQB1, TNF, IFNG, IL10, TAP1
6MP:00107686.7HLA-B, HLA-DQB1, TNF, IFNG, IL10, KLRK1
7MP:00053976.0TSPAN32, TNF, HLA-DQB1, HLA-B, IFNG, IL10
8MP:00053875.8CD36, HLA-B, HLA-DQB1, TNF, TSPAN32, MT-CO1

Publications for Alveolar Echinococcosis

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Articles related to Alveolar Echinococcosis:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Comparison of the serological tests ICT and ELISA for the diagnosis of alveolar echinococcosis in Francea98. (25058754)
2014
2
Immunodiagnosis of alveolar echinococcosis using urine samples. (23872436)
2013
3
PRIMARY CEREBRAL ALVEOLAR ECHINOCOCCOSIS: MYCOLOGY TO THE RESCUE. (24335950)
2013
4
Alveolar echinococcosis of the adrenal gland: brief review of two cases. (22800838)
2012
5
Mapping the increasing risk of human alveolar echinococcosis in Limburg, The Netherlands. (21733269)
2012
6
An uncommon reason for dyspnoea: phrenic paresis secondary to alveolar echinococcosis. (23024329)
2012
7
Parasite-specific IL-17-type cytokine responses and soluble IL-17 receptor levels in Alveolar Echinococcosis patients. (22969818)
2012
8
Alveolar echinococcosis: spectrum of findings at cross-sectional imaging. (23150858)
2012
9
Immunochromatographic test with recombinant Em18 antigen for the follow-up study of alveolar echinococcosis. (21715578)
2011
10
Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china. (20042519)
2010
11
Dot immunogold filtration assay (DIGFA) with multiple native antigens for rapid serodiagnosis of human cystic and alveolar echinococcosis. (19836341)
2010
12
Education and Imaging. Hepatobiliary and pancreatic: alveolar echinococcosis mimicking hepatocellular carcinoma. (20928949)
2010
13
Skin fistulization associated with extensive alveolar echinococcosis. (20406585)
2010
14
Pitfall alveolar echinococcosis in non-endemic areas. Alveolar echinococcosis migrating northward. (20308731)
2010
15
Giant hepatic alveolar echinococcosis in an adult. (19427628)
2009
16
Research on targeting sources of alveolar echinococcosis in Japan. (17662388)
2007
17
Human alveolar echinococcosis in Slovenia. (17371540)
2007
18
Stereological evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis using computed tomography via the Cavalieri method. (17105589)
2006
19
Socioeconomic and behavior risk factors of human alveolar echinococcosis in Tibetan communities in Sichuan, People's Republic of China. (16687693)
2006
20
Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients. (16879243)
2006
21
Alveolar echinococcosis in the zoological garden Basle. (16315852)
2005
22
Orthotopic liver transplantation for incurable alveolar echinococcosis: report of five cases from west China. (15964373)
2005
23
Secondary and primary murine alveolar echinococcosis: combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity. (15064126)
2004
24
Mediastinal recurrence of alveolar echinococcosis after liver transplantation. (12514779)
2003
25
HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China. (14570623)
2003
26
European echinococcosis registry: human alveolar echinococcosis, Europe, 1982-2000. (12643830)
2003
27
Development of Em18-immunoblot and Em18-ELISA for specific diagnosis of alveolar echinococcosis. (12606094)
2003
28
Evaluation of use of recombinant Em18 and affinity-purified Em18 for serological differentiation of alveolar echinococcosis from cystic echinococcosis and other parasitic infections. (12843091)
2003
29
Alveolar echinococcosis in Turkey. Experience from an endemic region. (12789026)
2003
30
Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: results of a blind test. (12409391)
2002
31
Molecular tools for the diagnosis of cystic and alveolar echinococcosis. (11422961)
2001
32
Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature. (10980173)
2000
33
Extrahepatic alveolar echinococcosis without liver involvement: a rare manifestation. (10879649)
2000
34
Alveolar echinococcosis of the pancreas. (10876195)
2000
35
Hepatic alveolar echinococcosis. A case report. (10335973)
1999
36
Primary disease recurrence after liver transplantation for alveolar echinococcosis: long-term evaluation in 15 patients. (10498634)
1999
37
Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis. (9875648)
1998
38
Cystic and alveolar echinococcosis in Turkey. (9924542)
1998
39
Imaging diagnosis of alveolar echinococcosis in young patients. (8995172)
1997
40
Epidemiology of alveolar echinococcosis in southern Germany (Bavaria). (7622269)
1995
41
Human alveolar echinococcosis seroprevalence assessed by western blotting in Hokkaido. (8531411)
1995
42
Association between HLA-DR13 and susceptibility to alveolar echinococcosis. (8195634)
1994
43
CT in lobar atrophy of the liver caused by alveolar echinococcosis. (1545016)
1992
44
Growing importance of prevention and control of alveolar echinococcosis. (1953939)
1991
45
Application of a recombinant Echinococcus multilocularis antigen in an enzyme-linked immunosorbent assay for immunodiagnosis of human alveolar echinococcosis. (2671725)
1989
46
Orthotopic liver transplantation in alveolar echinococcosis of the liver: analysis of a series of six patients. (2450418)
1988
47
An international study on the serological differential diagnosis of human cystic and alveolar echinococcosis. (3488132)
1986
48
Experimental alveolar echinococcosis. Suitability of a murine model of intrahepatic infection by Echinococcus multilocularis for immunological studies. (6510502)
1984
49
Hepatic alveolar echinococcosis invading pancreas, vertebrae, and spinal cord. (7129411)
1982
50
Immunomorphology and pathogenesis of echinococcosis. III: Microscopic immunofluorescence studies in experimental alveolar echinococcosis. (344225)
1978

Variations for Alveolar Echinococcosis

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Expression for genes affiliated with Alveolar Echinococcosis

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Expression patterns in normal tissues for genes affiliated with Alveolar Echinococcosis

Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for genes affiliated with Alveolar Echinococcosis

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Pathways related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CD8A, TAP2, TAP1
29.5HLA-DRB1, IFNG
3
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.5HLA-DQB1, HLA-DRB5, HLA-DRB1
4
Show member pathways
9.5HLA-DQB1, HLA-DRB5, HLA-DRB1
5
Show member pathways
9.5HLA-DRB1, HLA-DRB5, HLA-DQB1
69.5HLA-DRB1, HLA-DRB5, HLA-DQB1
7
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.5HLA-DRB1, HLA-DRB5, HLA-DQB1
8
Show member pathways
9.5HLA-DRB1, HLA-DRB5, HLA-DQB1
9
Show member pathways
TCR signaling in naive CD8+ T cells37
9.5CD8A, HLA-DRB1, HLA-A
10
Show member pathways
9.4HLA-C, HLA-A, HLA-B
119.4HLA-C, HLA-A, HLA-B
129.3IL10, IFNG
13
Show member pathways
9.3CD8A, HLA-DRB1, HLA-DRB5, HLA-DQB1
14
Show member pathways
9.3CD8A, HLA-DRB1, HLA-DRB5, HLA-DQB1
159.3TAP1, IFNG, HLA-B
169.2CD36, TNF
179.2IL10, TAP1, TAP2, CD8A
189.0TNF, IFNG
199.0HLA-DQB1, HLA-DRB5, HLA-DRB1, IL10
208.9HLA-B, HLA-A, HLA-C, KLRK1, CD8A
21
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.8HLA-A, HLA-DRB1, IFNG, CD8A
22
Show member pathways
8.8HLA-B, HLA-A, HLA-C, TAP1, TAP2
238.5TNF, IFNG, IL10
248.5TNF, IFNG, IL10
25
Show member pathways
IL27-mediated signaling events37
8.5TNF, IFNG, IL10
26
Show member pathways
8.5IL10, IFNG, TNF
278.5IL10, IFNG, TNF
28
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.5TNF, IFNG, IL10
298.4HLA-DRB5, HLA-DRB1, TNF, CD8A, CD36
30
Show member pathways
8.4HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
31
Show member pathways
Ras signaling in the CD4+ TCR pathway37
8.3CD8A, IFNG, TNF, HLA-A
32
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.3TNF, IFNG, IL10, CD8A
33
Show member pathways
8.2HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, TNF
348.2HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
358.2IL10, IFNG, TNF, HLA-DRB1
36
Show member pathways
8.1HLA-DQB1, HLA-DRB5, HLA-DRB1, TNF, IFNG
378.1IFNG, TNF, HLA-DRB1, HLA-DRB5, HLA-DQB1
387.9TNF, IFNG, IL10, KLRK1, CD36
39
Show member pathways
7.8HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
40
Show member pathways
Immune response CD16 signaling in NK cells60
7.7HLA-B, HLA-A, HLA-C, TNF, IFNG, KLRK1
417.6HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
427.6HLA-DQB1, HLA-DRB5, HLA-DRB1, TNF, IFNG, IL10
43
Show member pathways
7.6HLA-DQB1, HLA-DRB5, HLA-DRB1, TNF, IFNG, IL10
44
Show member pathways
7.6HLA-DQB1, HLA-DRB5, HLA-DRB1, TNF, IFNG, IL10
457.5CD36, TAP2, TAP1, HLA-DRB1, HLA-DRB5, HLA-C
467.3HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
47
Show member pathways
7.0HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
48
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
6.7HLA-B, HLA-A, HLA-C, TNF, IFNG, TAP1
49
Show member pathways
6.4HLA-DRB5, HLA-C, HLA-DQB1, HLA-A, HLA-B, HLA-DRB1
50
Show member pathways
5.7CD8A, TAP2, TAP1, IL10, IFNG, TNF

Compounds for genes affiliated with Alveolar Echinococcosis

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Compounds related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1solium4410.2HLA-B, MT-CO1
2dr-104410.1HLA-A, HLA-DRB1
3betaseron449.6IL10, IFNG
4glatiramer acetate44 1110.4HLA-DRB1, IFNG, IL10
5cdp571449.3IL10, TNF
6ribavirin44 50 1111.3IL10, IFNG, HLA-B
7ifn-alpha449.3IFNG, IL10, TAP1
8alpha-galactosylceramide449.2IL10, IFNG
9lipoteichoic acid449.2IL10, TNF, HLA-B
10gold sodium thiomalate449.1HLA-DRB1, TNF, IFNG
11allergens449.1IL10, IFNG, HLA-DRB1
12abacavir50 44 1111.1TNF, HLA-B
13taurine chloramine449.0IFNG, TNF
14budesonide44 50 1111.0TNF, IFNG, CD36
15interferon gamma449.0IL10, IFNG, TNF
16glucosamine44 24 1110.9TNF, IFNG, CD36
17natalizumab44 119.9IL10, IFNG, TNF
18il-12448.9TNF, IFNG, IL10
19adalimumab44 50 1110.9IL10, IFNG, TNF
20carbamazepine44 50 1110.9HLA-B, HLA-A, TNF, CD36
21indoleamine448.9IL10, IFNG, TNF
22imiquimod44 61 28 1111.9TNF, IFNG, IL10
23polymyxin b448.9IL10, IFNG, TNF
24okt3448.9IL10, IFNG, TNF
25oligonucleotide448.9HLA-B, HLA-A, HLA-DQB1, HLA-DRB1, TAP1, TAP2
26gm-csf44 289.9IL10, IFNG, TNF
27rolipram44 61 2810.9TNF, IFNG, IL10
28etanercept44 50 1110.9IL10, IFNG, TNF
29tarc448.8TNF, IFNG, IL10
30infliximab44 50 1110.8TNF, IFNG, IL10
31ivig448.8IL10, IFNG, TNF
32ccl344 289.8TNF, IFNG, IL10
33pentoxifylline44 119.8TNF, IFNG, IL10
34il 10448.7TNF, IFNG, IL10, CD8A
35neopterin448.7TNF, IFNG, IL10
362,5-oligoadenylate448.7HLA-B, TNF, IFNG, IL10
37endotoxin448.6HLA-B, TNF, IFNG, IL10
38mycophenolate mofetil44 50 1110.5TNF, IFNG, IL10, CD36
3915-deoxy-delta-12,14-prostaglandin j2448.5TNF, IFNG, IL10, CD36
40arginine448.5HLA-B, HLA-A, HLA-DRB1, IFNG, KLRK1
41thalidomide44 50 61 1111.5CD36, IL10, IFNG, TNF
42rantes448.5HLA-B, TNF, IFNG, IL10
43hydrocortisone44 2 61 1111.5TNF, IFNG, IL10, CD36
44calcitriol44 61 24 1111.5CD36, IL10, IFNG, TNF
45polyinosinic-polycytidylic acid448.4KLRK1, IL10, IFNG, TNF, HLA-B
46sb 20358044 619.3TNF, IFNG, IL10, CD36
47pge2448.2HLA-B, TNF, IFNG, IL10, CD36
48cyclosporin a44 28 6110.1HLA-B, HLA-A, TNF, IFNG, IL10
49dexamethasone44 50 28 1110.9HLA-B, TNF, IFNG, IL10, CD36
50tacrolimus44 50 119.8HLA-B, HLA-A, TNF, IFNG, IL10, CD36

GO Terms for genes affiliated with Alveolar Echinococcosis

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Cellular components related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.7HLA-DRB1, HLA-DRB5, HLA-DQB1
2clathrin-coated endocytic vesicle membraneGO:0306699.6HLA-DQB1, HLA-DRB5, HLA-DRB1
3TAP complexGO:0428259.6TAP2, TAP1
4MHC class I protein complexGO:0426129.6HLA-C, HLA-A, HLA-B
5transport vesicle membraneGO:0306589.6HLA-DRB1, HLA-DRB5, HLA-DQB1
6trans-Golgi network membraneGO:0325889.5HLA-DQB1, HLA-DRB5, HLA-DRB1
7early endosome membraneGO:0319019.4HLA-C, HLA-A, HLA-B
8endocytic vesicle membraneGO:0306669.4HLA-DQB1, HLA-DRB5, HLA-DRB1, CD36
9phagocytic vesicle membraneGO:0306709.3HLA-C, HLA-A, HLA-B
10integral component of lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-DRB1, HLA-DRB5, HLA-C, HLA-DQB1, HLA-A, HLA-B
11ER to Golgi transport vesicle membraneGO:0125078.7HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
12Golgi membraneGO:0001398.6HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
13external side of plasma membraneGO:0098978.1HLA-DRB5, HLA-DRB1, TNF, IFNG, CD8A, CD36
14cell surfaceGO:0099867.9HLA-B, HLA-A, HLA-C, TNF, TSPAN32, CD36
15integral component of plasma membraneGO:0058877.7HLA-B, HLA-A, HLA-C, HLA-DRB1, TNF, CD8A
16plasma membraneGO:0058866.7HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1

Biological processes related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.3TAP2, TAP1
2oligopeptide transmembrane transportGO:03567210.3TAP1, TAP2
3antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.3TAP1, TAP2
4intracellular transport of viral protein in host cellGO:01906010.3TAP1, TAP2
5regulation of interleukin-10 secretionGO:200117910.3HLA-DRB5, HLA-DRB1
6regulation of interleukin-4 productionGO:03267310.3HLA-DRB5, HLA-DRB1
7peptide transportGO:01583310.2TAP1, TAP2
8T-helper 1 type immune responseGO:04208810.2HLA-DRB1, HLA-DRB5
9inflammatory response to antigenic stimulusGO:00243710.1HLA-DRB1, HLA-DRB5
10positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:03577410.1HLA-DRB5, HLA-DRB1
11immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.9HLA-DRB1, HLA-DRB5, HLA-DQB1
12humoral immune response mediated by circulating immunoglobulinGO:0024559.9HLA-DRB1, HLA-DRB5, HLA-DQB1
13protein tetramerizationGO:0512629.9HLA-DRB1, HLA-DRB5
14T cell costimulationGO:0312959.9HLA-DQB1, HLA-DRB5, HLA-DRB1
15T cell receptor signaling pathwayGO:0508529.8HLA-DRB1, HLA-DRB5, HLA-DQB1
16negative regulation of myeloid dendritic cell activationGO:0308869.8TSPAN32, IL10
17antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.8HLA-DQB1, HLA-DRB5, HLA-DRB1
18antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:0024869.8HLA-B, HLA-A, HLA-C
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.8HLA-B, HLA-A, HLA-C
20negative regulation of interferon-gamma productionGO:0326899.8IL10, HLA-DRB1, HLA-DRB5
21negative regulation of T cell proliferationGO:0421309.8HLA-DRB5, HLA-DRB1, IL10
22type I interferon signaling pathwayGO:0603379.7HLA-C, HLA-A, HLA-B
23positive regulation of MHC class II biosynthetic processGO:0453489.7IFNG, IL10
24detection of bacteriumGO:0160459.6HLA-B, HLA-A, HLA-DRB5, HLA-DRB1
25regulation of immune responseGO:0507769.6CD8A, HLA-C, HLA-A, HLA-B
26defense response to protozoanGO:0428329.6TSPAN32, IFNG
27receptor biosynthetic processGO:0328009.5TNF, IL10
28positive regulation of interleukin-12 productionGO:0327359.5IFNG, CD36
29negative regulation of cytokine secretion involved in immune responseGO:0027409.5TNF, IL10
30positive regulation of vitamin D biosynthetic processGO:0605579.4IFNG, TNF
31positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4TNF, IFNG
32positive regulation of chemokine biosynthetic processGO:0450809.3IFNG, TNF
33positive regulation of membrane protein ectodomain proteolysisGO:0510449.3IFNG, TNF
34negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF
35positive regulation of T cell mediated cytotoxicityGO:0019169.3HLA-B, HLA-A, HLA-C, TAP1, TAP2
36cellular response to lipopolysaccharideGO:0712229.3CD36, IL10, IFNG
37positive regulation of osteoclast differentiationGO:0456729.2IFNG, TNF
38protein import into nucleus, translocationGO:0000609.1IFNG, TNF
39positive regulation of cytokine secretionGO:0507159.1IL10, TNF
40response to activityGO:0148239.0IL10, TNF
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024798.9HLA-B, HLA-A, HLA-C, TAP1, TAP2, CD36
42antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425908.9HLA-B, HLA-A, HLA-C, TAP1, TAP2, CD36
43antigen processing and presentation of peptide antigen via MHC class IGO:0024748.9HLA-B, HLA-A, HLA-C, TAP1, TAP2, CD36
44positive regulation of nitric oxide biosynthetic processGO:0454298.7IFNG, TNF
45immune responseGO:0069558.6HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
46negative regulation of growth of symbiont in hostGO:0441308.5TNF, IFNG, IL10, CD36
47interferon-gamma-mediated signaling pathwayGO:0603338.2IFNG, HLA-DRB1, HLA-DRB5, HLA-C, HLA-DQB1, HLA-A
48cytokine-mediated signaling pathwayGO:0192218.2HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1

Molecular functions related to Alveolar Echinococcosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.1TAP1, TAP2
2MHC class Ib protein bindingGO:02302910.1TAP1, TAP2
3peptide transporter activityGO:01519710.0TAP1, TAP2
4oligopeptide-transporting ATPase activityGO:01542110.0TAP2, TAP1
5TAP2 bindingGO:0469799.9TAP1, TAP2
6MHC class I protein bindingGO:0422889.9CD8A, TAP2, TAP1
7TAP1 bindingGO:0469789.8TAP1, TAP2
8TAP bindingGO:0469779.6HLA-B, HLA-A, HLA-C
9MHC class II receptor activityGO:0323959.5HLA-DRB1, HLA-DQB1
10cytokine activityGO:0051258.5IL10, IFNG, TNF
11peptide antigen bindingGO:0426058.5TAP2, TAP1, HLA-DRB1, HLA-DRB5, HLA-C, HLA-A

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
43NINDS
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