Alveolar Echinococcosis malady

Disease Ontology: An echinococcosis that is caused by the larvae of echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.⁶

MalaCards: Alveolar Echinococcosis, also known as multilocular hydatid, is related to cystic echinococcosis and hepatitis. An important gene associated with Alveolar Echinococcosis is TSPAN32 (tetraspanin 32), and among its related pathways are Immune response Antigen presentation by MHC class II and Cell adhesion molecules (CAMs). The compounds dr-10 and solium have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia: Alveolar hydatid disease (AHD), also known as alveolar echinococcosis, alveolar colloid of the liver,...⁴⁴ more...

Aliases & Descriptions:

alveolar echinococcosis 6 30 43 multilocular hydatid 6 cestode infections 43

small fox tapeworm 6 alveolococcosis 6 echinococcosis 30

Diseases related to alveolar echinococcosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 460)

id	Related Disease	Score	Top Affiliating Genes
1	cystic echinococcosis	33.0	MT-CO1, HLA-B, HLA-DRB1, TAP1, TAP2
2	hepatitis	29.7	HLA-A, HLA-DRB1, TAP2
3	cysticercosis	28.4	MT-CO1, IL10, TNF
4	echinococcosis	28.1	MT-CO1, CD8A, IL10, IFNG, HLA-A, HLA-B
5	birdshot chorioretinopathy	13.2	HLA-A, HLA-C
6	posterior uveal melanoma	13.2	TAP1, TAP2
7	multiple sclerosis	13.2	HLA-DQB1, HLA-DRB1
8	tubulointerstitial nephritis and uveitis	13.2	HLA-DQB1, HLA-DRB1
9	bare lymphocyte syndrome	13.1	HLA-A, TAP1, TAP2
10	sapho syndrome	13.1	HLA-B, TNF
11	cervical dystonia	13.1	HLA-DQB1, HLA-DRB1
12	common wart	13.1	HLA-DQB1, HLA-DRB1
13	htlv-1 associated myelopathy	13.0	HLA-A, HLA-B, HLA-C
14	peyronies disease	13.0	HLA-A, HLA-B, HLA-C
15	punctate inner choroidopathy	13.0	IL10, TNF
16	immunodysregulation	13.0	IL10, HLA-DRB1
17	palindromic rheumatism	13.0	HLA-DRB1, TNF
18	hypersomnia	13.0	HLA-DQB1, HLA-DRB1
19	panuveitis	13.0	IL10, TNF
20	sepsis	13.0	IL10, TNF
21	postherpetic neuralgia	12.9	HLA-A, HLA-B, HLA-DRB1
22	rheumatoid vasculitis	12.9	HLA-DRB1, TNF
23	primary systemic mycosis	12.9	IL10, TNF
24	pars planitis	12.9	HLA-A, HLA-B, HLA-DRB1
25	recurrent respiratory papillomatosis	12.9	HLA-DQB1, HLA-DRB1, TAP1
26	whipple disease	12.9	HLA-B, HLA-DQB1, HLA-DRB1
27	porphyria cutanea tarda	12.9	HLA-A, HLA-B, HLA-DRB1
28	psoriatic arthritis	12.9	IL10, TNF
29	nasopharynx carcinoma	12.8	HLA-A, HLA-B, KLRK1, TAP1
30	coccidiosis	12.8	CD8A, IFNG
31	cryptorchidism	12.8	CD8A, HLA-DQB1, HLA-DRB1
32	variegate porphyria	12.8	HLA-A, HLA-B, HLA-DRB1
33	nephropathia epidemica	12.8	HLA-B, HLA-DRB1, TNF
34	autoimmune hepatitis	12.8	HLA-A, HLA-DQB1, HLA-DRB1
35	chronic venous leg ulcers	12.7	HLA-B, HLA-DRB1, TNF
36	dengue shock syndrome	12.7	HLA-A, HLA-DRB1, TNF
37	t-cell large granular lymphocyte leukemia	12.7	IL10, TNF
38	tuberculous uveitis	12.7	IFNG, TNF
39	ankylosing spondylitis	12.7	HLA-B, TNF, TAP1, TAP2
40	febrile seizures	12.7	IL10, TNF, SLC4A3
41	berylliosis	12.7	IFNG, HLA-DRB1
42	buruli ulcer disease	12.7	IL10, IFNG
43	tuberculoid leprosy	12.7	IL10, IFNG
44	leprosy	12.7	IL10, HLA-DQB1, HLA-DRB1
45	ocular cicatricial pemphigoid	12.7	HLA-DQB1, HLA-DRB1, TNF
46	spondylarthropathy	12.7	IL10, HLA-B, TNF
47	disseminated intravascular coagulation	12.7	IL10, TNF, TSPAN32
48	mixed connective tissue disease	12.7	HLA-A, HLA-DRB1, TNF
49	celiac disease	12.7	HLA-DQB1, HLA-DRB1, TNF
50	cork-handlers' disease	12.7	HLA-B, HLA-C, TNF

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to alveolar echinococcosis:

²²

MGI Mouse Phenotypes related to alveolar echinococcosis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	8.6	TAP1, KLRK1, HLA-DQB1, HLA-C, CD8A
2	immune system phenotype	MP:0005387	8.0	IFNG, HLA-C, HLA-DQB1, TNF, TSPAN32
3	cellular phenotype	MP:0005384	6.0	TAP1, TSPAN32, KLRK1, TNF, HLA-DQB1, HLA-C

Articles related to alveolar echinococcosis:

(show all 16)

id	Title	Authors	Year	Affiliating Genes
1	Histopathological, serological, and molecular confirm ation of indigenous alveolar echinococcosis cases in Mongolia. (20134004)	Ito A.... Dulmaa N.	2010	MT-CO1
2	Specific IgG responses to recombinant antigen B and e m18 in cystic and alveolar echinococcosis in china. (20042519)	Li T.... Craig P.S.	2010	HLA-B
3	Evaluation of Echinococcus multilocularis tetraspanin s as vaccine candidates against primary alveolar echinococcosis. (19782112)	Dang Z.... Sugimoto C.	2009	TSPAN32
4	Genetic analysis of Echinococcus multilocularis originating from a patient with alveolar echinococcosis occurring in Minnesota in 1977. (18689631)	Yamasaki H.... Ito A.	2008	MT-CO1
5	Expression of major histocompatibility complex class I chain-related molecule A, NKG2D, and transforming growth factor-beta in the liver of humans with alveolar echinococcosis: new actors in the tolerance to parasites? (18422447)	Zhang S.... Vuitton D.A.	2008	KLRK1
6	Association between hepatic alveolar echinococcosis and frequency of human leukocyte antigen class I and II alleles in Turkish patients. (17573956)	Aydinli B.... Donmez R.	2007	HLA-A, HLA-DQB1, HLA-DRB1
7	Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients. (16879243)	HA1bner M.P.... Soboslay P.T.	2006	TNF
8	HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China. (14570623)	Li F.... Craig P.S.	2003	HLA-DRB1
9	Development of Em18-immunoblot and Em18-ELISA for specific diagnosis of alveolar echinococcosis. (12606094)	Ito A.... Ishikawa Y.	2003	HLA-B
10	Polymorphisms of the TAP1 and TAP2 genes in human alveolar echinococcosis. (12648282)	Zhang S.... Vuitton D.A.	2003	TAP1, TAP2
11	Profile of cytokine production within the periparasitic granuloma in human alveolar echinococcosis. (12606101)	Harraga S.... Vuitton D.A.	2003	IFNG, IL10
12	Association of HLA-DRB1 allele and the susceptibility to alveolar echinococcosis in the west of China (11798795)	Li F.... Shi D.	2000	HLA-DRB1, HLA-DRB5
13	Differential serodiagnosis for cystic and alveolar echinococcosis using fractions of Echinococcus granulosus cyst fluid (antigen B) and E. multilocularis protoscolex (EM18). (10072134)	Ito A.... Pawlowski Z.S.	1999	HLA-B
14	Cellular localisations of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha mRNA in a parasitic granulomatous disease of the liver, alveolar echinococcosis. (7880977)	Bresson-Hadni S.... Vuitton D.A.	1994	TNF
15	Immunoglobulin G subclass responses in human cystic a nd alveolar echinococcosis. (7810806)	Wen H.... Craig P.S.	1994	HLA-B
16	Soluble IL-2-receptor and CD8 in the serum and the periparasitic granuloma of patients with alveolar echinococcosis. (1804323)	Bresson-Hadni S.... Vuitton D.A.	1991	CD8A

Genes related to alveolar echinococcosis according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	TSPAN32	tetraspanin 32	11.0	Publications
2	SLC4A3	solute carrier family 4, anion exchanger, member 3	11.0
3	CD8A	CD8a molecule	11.0	Publications
4	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
5	KLRK1	killer cell lectin-like receptor subfamily K, member 1	11.0	Publications
6	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
7	HLA-DRB5	major histocompatibility complex, class II, DR beta 5	11.0	Publications
8	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
9	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
10	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
11	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
12	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
13	MT-CO1	mitochondrially encoded cytochrome c oxidase I	11.0	Publications
14	IL10	interleukin 10	11.0	Publications
15	TNF	tumor necrosis factor	11.0	Publications
16	IFNG	interferon, gamma	11.0	Publications

Pathways related to alveolar echinococcosis according to GeneDecks:

(show top 50)    (show all 52)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Antigen presentation by MHC class II10	10.5	HLA-DRB5
2	Cell adhesion molecules (CAMs)20	10.4	CD8A, HLA-DRB5
3	CTLA4 Signaling36	10.3	HLA-DRB5, CD8A
4	Primary immunodeficiency20	10.3	TAP1, TAP2
5	Immune response_ICOS pathway in T-helper cell41	10.1	HLA-DRB5
6	MHC class II antigen presentation38	9.7	HLA-DRB5, HLA-DRB1, HLA-DQB1
7	Immune response_Antigen presentation by MHC class II41	9.6	HLA-DQB1, HLA-DRB1, HLA-DRB5
8	Calcium Mediated T-Cell Apoptosis36	9.6	HLA-DQB1, HLA-DRB1, HLA-DRB5
9	G-protein signaling N-RAS regulation pathway10	9.6	HLA-DRB5, HLA-DRB1, HLA-DQB1
10	Immune response Antigen presentation by MHC class I10	9.6	HLA-C, HLA-B, HLA-A, CD8A
11	G-protein signaling_N-RAS regulation pathway41	9.6	HLA-DQB1, HLA-DRB1, HLA-DRB5
12	Immune response IL-22 signaling pathway10	9.6	HLA-DRB5, HLA-DRB1, HLA-DQB1
13	Immune System38	9.6	IFNG, KLRK1, TAP1, TAP2
14	Graft-versus-host disease20	9.5	HLA-A, HLA-B, HLA-C, HLA-DRB5
15	IL-4 Pathway36	9.5	HLA-DRB5, HLA-DRB1, HLA-DQB1
16	Immune response_IL-22 signaling pathway41	9.5	HLA-DQB1, HLA-DRB1, HLA-DRB5
17	Immune response T cell receptor signaling pathway10	9.5	HLA-DRB5, HLA-DRB1, HLA-DQB1
18	ICos-ICosL Pathway in T-Helper Cell36	9.5	HLA-DQB1, HLA-DRB1, HLA-DRB5
19	PKC-Theta Pathway36	9.4	HLA-DRB5, HLA-DRB1, HLA-DQB1, CD8A
20	Immune response NFAT in immune response10	9.4	HLA-DRB5, HLA-DQB1
21	Immune response_T cell receptor signaling pathway41	9.4	HLA-DRB5, HLA-DRB1, HLA-DQB1
22	TCR Signaling36	9.4	HLA-DRB5, HLA-DRB1, HLA-DQB1, CD8A
23	Immune response_Antigen presentation by MHC class I41	9.4	TAP2, TAP1, HLA-C, HLA-A, CD8A
24	Immune response ICOS pathway in T-helper cell10	9.3	HLA-DQB1, HLA-DRB1, HLA-DRB5
25	CD28 Signaling in T-Helper Cell36	9.3	HLA-DQB1, HLA-DRB1, HLA-DRB5
26	Intestinal immune network for IgA production20	9.1	IL10, HLA-DQB1, HLA-DRB1, HLA-DRB5
27	Staphylococcus aureus infection20	9.1	HLA-DRB5, HLA-DRB1, HLA-DQB1, IL10
28	Hematopoietic cell lineage20	9.1	CD8A, HLA-DRB1, HLA-DRB5, TNF
29	Cytokine Network36	8.8	TNF, IFNG, IL10
30	African trypanosomiasis20	8.8	IL10, IFNG, TNF
31	Th1 Differentiation37	8.8	TNF, IFNG, IL10
32	CTL Mediated Apoptosis36	8.7	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A
33	Viral myocarditis20	8.7	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A
34	CDC42 Pathway36	8.7	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A
35	Antigen processing and presentation20	8.7	CD8A, HLA-C, HLA-DQB1, HLA-DRB1, HLA-DRB5, TAP1
36	Malaria20	8.6	KLRK1, TNF, IFNG, IL10
37	T cell receptor signaling pathway20	8.6	CD8A, IL10, IFNG, TNF
38	Rheumatoid arthritis20	8.4	TNF, HLA-DRB5, HLA-DRB1, HLA-DQB1, IFNG
39	Influenza A20	8.4	IFNG, HLA-DQB1, HLA-DRB1, HLA-DRB5, TNF
40	Asthma20	8.3	TNF, HLA-DRB5, HLA-DRB1, HLA-DQB1, IL10
41	Natural killer cell mediated cytotoxicity20	8.2	KLRK1, TNF, HLA-C, HLA-B, HLA-A, IFNG
42	Phagosome20	8.2	TAP2, TAP1, HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C
43	Autoimmune thyroid disease20	8.1	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A
44	THC Differentiation Pathway36	7.8	TNF, HLA-DRB5, HLA-DRB1, HLA-DQB1, IFNG, IL10
45	Leishmaniasis20	7.8	TNF, HLA-DRB5, HLA-DRB1, HLA-DQB1, IFNG, IL10
46	Toxoplasmosis20	7.8	TNF, HLA-DRB5, HLA-DRB1, HLA-DQB1, IFNG, IL10
47	Systemic lupus erythematosus20	7.8	TNF, HLA-DRB5, HLA-DRB1, HLA-DQB1, IFNG, IL10
48	Tuberculosis20	7.8	TNF, HLA-DRB5, HLA-DRB1, HLA-DQB1, IFNG, IL10
49	Type I diabetes mellitus20	7.4	TNF, IFNG, HLA-A, HLA-B, HLA-C, HLA-DQB1
50	Allograft rejection20	6.8	TNF, HLA-DRB5, HLA-DRB1, IL10, IFNG, HLA-A

Compounds related to alveolar echinococcosis according to GeneDecks:

(show all 41)

id	Compound	Score	Top Affiliating Genes
1	dr-1032	10.1	HLA-A, HLA-DRB1
2	solium32	10.0	MT-CO1, HLA-B
3	betaseron32	9.6	IFNG, IL10
4	alpha-galactosylceramide32	9.4	IL10, IFNG
5	okt332	9.4	TNF, IL10
6	glatiramer acetate32 9 9	11.4	HLA-DRB1, IFNG, IL10
7	cdp57132	9.3	TNF, IL10
8	ifn-alpha32	9.3	TAP1, IFNG, IL10
9	taurine chloramine32	9.2	TNF, IFNG
10	gold sodium thiomalate32	9.2	TNF, HLA-DRB1, IFNG
11	allergens32	9.1	HLA-DRB1, IFNG, IL10
12	vesnarinone32	9.1	TNF, IFNG
13	lipoteichoic acid32	9.1	IL10, HLA-B, TNF
14	toxin-132	9.0	IL10, TNF
15	interferon gamma32	8.9	IL10, IFNG, TNF
16	gabexate mesilate32	8.9	IL10, TNF
17	natalizumab32 9 9	10.9	IL10, IFNG, TNF
18	adalimumab32 9 9	10.9	TNF, IFNG, IL10
19	imiquimod32 42 9 9	11.9	IL10, IFNG, TNF
20	il-1232	8.9	IL10, IFNG, TNF
21	indoleamine32	8.9	TNF, IFNG, IL10
22	polymyxin b32	8.9	TNF, IFNG, IL10
23	rolipram32 42	9.9	TNF, IFNG, IL10
24	gm-csf32	8.9	TNF, IFNG, IL10
25	etanercept32 9 9	10.9	IL10, IFNG, TNF
26	infliximab32 9 9	10.8	TNF, IFNG, IL10
27	tarc32	8.8	IL10, IFNG, TNF
28	ivig32	8.8	IL10, IFNG, TNF
29	ccl332	8.8	TNF, IFNG, IL10
30	pentoxifylline32 9 9	10.8	TNF, IFNG, IL10
31	thalidomide32 42 9 9	11.7	TNF, IFNG, IL10
32	oligonucleotide32	8.7	TAP2, TAP1, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A
33	ulinastatin32	8.7	IL10, TNF
34	neopterin32	8.7	IL10, IFNG, TNF
35	il 1032	8.7	TNF, IFNG, IL10, CD8A
36	15-deoxy-delta-12,14-prostaglandin j232	8.7	TNF, IFNG, IL10
37	2,5-oligoadenylate32	8.6	TNF, HLA-B, IFNG, IL10
38	rantes32	8.4	TNF, HLA-B, IFNG, IL10
39	polyinosinic-polycytidylic acid32	8.3	IL10, IFNG, HLA-B, TNF, KLRK1
40	tacrolimus32 34 9 9	11.2	TNF, HLA-B, HLA-A, IFNG, IL10
41	cyclosporin a32 42	9.1	TNF, HLA-B, HLA-A, IFNG, IL10

Cellular components related to alveolar echinococcosis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi membrane	GO:000139	9.9	HLA-DRB5, HLA-DQB1
2	TAP complex	GO:042825	9.8	TAP1, TAP2
3	MHC class I protein complex	GO:042612	9.6	HLA-A, HLA-B, HLA-C
4	MHC class II protein complex	GO:042613	9.6	HLA-DQB1, HLA-DRB1, HLA-DRB5
5	clathrin-coated endocytic vesicle membrane	GO:030669	9.5	HLA-DRB5, HLA-DRB1, HLA-DQB1
6	phagocytic vesicle membrane	GO:030670	9.5	HLA-C, HLA-B, HLA-A
7	trans-Golgi network membrane	GO:032588	9.5	HLA-DQB1, HLA-DRB1, HLA-DRB5
8	transport vesicle membrane	GO:030658	9.4	HLA-DRB5, HLA-DRB1, HLA-DQB1
9	early endosome membrane	GO:031901	9.4	HLA-A, HLA-B, HLA-C
10	endocytic vesicle membrane	GO:030666	9.0	HLA-DRB5, HLA-DRB1, HLA-DQB1
11	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	8.5	HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRB1, HLA-DRB5
12	ER to Golgi transport vesicle membrane	GO:012507	8.5	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A
13	external side of plasma membrane	GO:009897	8.5	TNF, HLA-DRB5, HLA-DRB1, IFNG, CD8A
14	integral to plasma membrane	GO:005887	7.7	SLC4A3, TNF, HLA-DRB1, HLA-C, HLA-B, HLA-A

Biological processes related to alveolar echinococcosis according to GeneDecks:

(show all 35)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol to ER transport	GO:046967	10.3	TAP1, TAP2
2	intracellular transport of viral proteins in host cell	GO:019060	10.2	TAP2, TAP1
3	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO:019885	10.2	TAP1, TAP2
4	regulation of interleukin-4 production	GO:032673	10.1	HLA-DRB1, HLA-DRB5
5	regulation of interleukin-10 secretion	GO:2001179	10.1	HLA-DRB1, HLA-DRB5
6	inflammatory response to antigenic stimulus	GO:002437	10.0	HLA-DRB5, HLA-DRB1
7	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:035774	9.9	HLA-DRB5, HLA-DRB1
8	T-helper 1 type immune response	GO:042088	9.9	HLA-DRB1, HLA-DRB5
9	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	9.8	HLA-C, HLA-B, HLA-A
10	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	9.7	HLA-DRB5, HLA-DRB1, HLA-DQB1
11	humoral immune response mediated by circulating immunoglobulin	GO:002455	9.7	HLA-DQB1, HLA-DRB1, HLA-DRB5
12	type I interferon-mediated signaling pathway	GO:060337	9.7	HLA-C, HLA-B, HLA-A
13	T cell costimulation	GO:031295	9.6	HLA-DQB1, HLA-DRB1, HLA-DRB5
14	positive regulation of MHC class II biosynthetic process	GO:045348	9.6	IL10, IFNG
15	negative regulation of interferon-gamma production	GO:032689	9.5	IL10, HLA-DRB1, HLA-DRB5
16	negative regulation of T cell proliferation	GO:042130	9.5	HLA-DRB5, HLA-DRB1, IL10
17	regulation of immune response	GO:050776	9.5	HLA-C, HLA-B, HLA-A, CD8A
18	T cell receptor signaling pathway	GO:050852	9.5	HLA-DQB1, HLA-DRB1, HLA-DRB5
19	detection of bacterium	GO:016045	9.5	HLA-DRB5, HLA-DRB1, HLA-B, HLA-A
20	positive regulation of vitamin D biosynthetic process	GO:060557	9.5	IFNG, TNF
21	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.5	TNF, IFNG
22	receptor biosynthetic process	GO:032800	9.4	TNF, IL10
23	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	9.3	HLA-DQB1, HLA-DRB1, HLA-DRB5
24	positive regulation of chemokine biosynthetic process	GO:045080	9.3	TNF, IFNG
25	negative regulation of cytokine secretion involved in immune response	GO:002740	9.3	TNF, IL10
26	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	9.3	TAP2, TAP1, HLA-C, HLA-B, HLA-A
27	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	9.3	TAP2, TAP1, HLA-C, HLA-B, HLA-A
28	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	9.2	HLA-A, HLA-B, HLA-C, TAP1, TAP2
29	positive regulation of osteoclast differentiation	GO:045672	9.1	IFNG, TNF
30	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.0	TNF, IFNG
31	negative regulation of growth of symbiont in host	GO:044130	8.9	IL10, IFNG, TNF
32	negative regulation of interleukin-6 production	GO:032715	8.7	IL10, TNF
33	immune response	GO:006955	8.4	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A
34	interferon-gamma-mediated signaling pathway	GO:060333	8.2	IFNG, HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B
35	cytokine-mediated signaling pathway	GO:019221	8.2	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-C, HLA-B, HLA-A

Molecular functions related to alveolar echinococcosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	TAP1 binding	GO:046978	9.8	TAP2, TAP1
2	MHC class II receptor activity	GO:032395	9.6	HLA-DQB1, HLA-DRB1
3	peptide transporter activity	GO:015197	9.6	TAP2, TAP1
4	peptide antigen binding	GO:042605	9.5	HLA-DRB1, HLA-DRB5, TAP1
5	MHC class I receptor activity	GO:032393	9.5	HLA-A, HLA-B, HLA-C