MCID: ALV002
MIFTS: 51

Alveolar Echinococcosis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Alveolar Echinococcosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 65UMLS, 27ICD10, 29ICD9CM, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 10 45 12 51 65
Echinococcus Multilocularis Infection 10 65
Echinococcosis 45 65
 
Multilocular Hydatid 10
Small Fox Tapeworm 10
Alveolococcosis 10

Characteristics:

Orphanet epidemiological data:

51
alveolar echinococcosis:
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly

Classifications:



External Ids:

Disease Ontology10 DOID:12148
ICD1027 B67.6, B67.7
ICD9CM29 122.7
Orphanet51 284
SNOMED-CT59 21009004, 240816000
ICD10 via Orphanet28 B67.5, B67.6, B67.7
MESH via Orphanet37 C536591
UMLS via Orphanet66 C0948954
UMLS65 C0152069, C0948954

Summaries for Alveolar Echinococcosis

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Disease Ontology:10 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary: Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to echinococcosis and retinitis, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways are Cytokines and Inflammatory Response and LDL Oxidation in Atherogenesis. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related mouse phenotype immune system.

Related Diseases for Alveolar Echinococcosis

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Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 384)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis31.7HLA-DRB1, MT-CO1
2retinitis30.6HLA-A, HLA-B
3hypopharynx cancer30.3HLA-DRB1, TNF
4primary ciliary dyskinesia30.2HLA-B, HLA-DRB1, TNF
5hemolytic anemia30.1HLA-A, HLA-B, TNF
6malaria29.5CD36, CD8A, HLA-A, HLA-B, HLA-DRB1, TNF
7cystic echinococcosis11.0
8congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome10.4HLA-DRB1, TNF
9pityriasis rosea10.4CD8A, HLA-DRB1
10androgen insensitivity syndrome, mild10.4HLA-DRB1, TNF
11lujo hemorrhagic fever10.4HLA-DRB1, TNF
12endotheliitis10.4
13drug-induced mental disorder10.4HLA-DRB1, TNF
14inflammatory leiomyosarcoma10.4CD8A, HLA-DRB1
15rhizomelic dysplasia patterson lowry type10.4HLA-DRB1, TNF
16ureterocele10.4CD8A, TNF
17breast cancer10.4
18hepatitis10.4
19anti-hla hyperimmunization10.4HLA-B, TNF
20collagenous colitis10.4HLA-DRB1, TNF
21achalasia10.4CD8A, TNF
22hemorrhagic proctocolitis10.4HLA-DRB1, TNF
23brucella melitensis brucellosis10.3CD36, TNF
24periventricular leukomalacia10.3HLA-A, HLA-B
25streptococcal meningitis10.3CD8A, TNF
26neuronitis10.3
27b cell deficiency10.3CD8A, TNF
28iridocyclitis10.3HLA-A, HLA-B
29hydromyelia10.3HLA-A, HLA-B
30anthracosis10.3HLA-A, HLA-B
31aniseikonia10.3CD8A, TNF
32undetermined early-onset epileptic encephalopathy10.3HLA-A, HLA-B
33vein disease10.3CD36, CD8A
34prostate malignant phyllodes tumor10.3HLA-A, HLA-B
35acquired thrombocytopenia10.3HLA-A, HLA-B
36chromosome 9p deletion syndrome10.3CD8A, TNF
37lacrimal duct obstruction10.3HLA-A, HLA-B
38soft palate cancer10.3CD8A, TNF
39human herpesvirus 810.3HLA-A, HLA-B
40gonococcal iridocyclitis10.3HLA-A, HLA-B
41estrogen excess10.3HLA-A, HLA-B
42idiopathic spinal cord herniation10.3HLA-DRB1, TNF
43malignant hypertension10.3HLA-A, HLA-B
44microsomia hemifacial radial defects10.3HLA-B, HLA-DRB1, TNF
45hypercementosis10.3HLA-B, HLA-DRB1, TNF
46juvenile pilocytic astrocytoma10.3HLA-A, HLA-B
47limited scleroderma10.2HLA-B, HLA-DRB1, TNF
48tumor necrosis factor receptor 1 associated periodic syndrome10.2TAP1, TAP2
49glycogen storage disease iiia10.2HLA-A, HLA-B
50myocardial infarction10.2

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to alveolar echinococcosis

Symptoms for Alveolar Echinococcosis

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Symptoms:

 51 (show all 45)
  • pruritus/itching
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • polycystic liver disease/hepatic cysts
  • hepatitis/icterus/cholestasis
  • extrahepatic biliary tract atresia/obstruction
  • hepatomegaly/liver enlargement (excluding storage disease)
  • anaemia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • visual loss/blindness/amblyopia
  • anomalies of spine, vertebrae and pelvis
  • anomalies of skin, subcutaneous tissue and mucosae
  • ascitis
  • esophageal varices
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • peritonitis/peritoneal abscess
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • cirrhosis
  • chronic hepatic failure
  • portal hypertension
  • splenomegaly
  • lung/pulmonary infiltrates
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • abnormal/polycystic ovaries
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • transient cerebral ischemia/stroke
  • cranial hypertension
  • ataxia/incoordination/trouble of the equilibrium
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • elocution disorders/dysarthria/dysphonia
  • muscle anomalies
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone cyst
  • severe allergic reaction/atopy
  • benign tumor of the brain/nervous system
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Alveolar Echinococcosis:

(show all 38)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 weight loss typical (50%) HP:0001824
6 anemia typical (50%) HP:0001903
7 hepatomegaly typical (50%) HP:0002240
8 abnormality of temperature regulation typical (50%) HP:0004370
9 extrahepatic biliary duct atresia typical (50%) HP:0005242
10 polycystic ovaries occasional (7.5%) HP:0000147
11 visual impairment occasional (7.5%) HP:0000505
12 seizures occasional (7.5%) HP:0001250
13 cirrhosis occasional (7.5%) HP:0001394
14 portal hypertension occasional (7.5%) HP:0001409
15 ascites occasional (7.5%) HP:0001541
16 splenomegaly occasional (7.5%) HP:0001744
17 esophageal varix occasional (7.5%) HP:0002040
18 migraine occasional (7.5%) HP:0002076
19 respiratory insufficiency occasional (7.5%) HP:0002093
20 hemoptysis occasional (7.5%) HP:0002105
21 pulmonary infiltrates occasional (7.5%) HP:0002113
22 neurological speech impairment occasional (7.5%) HP:0002167
23 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
24 incoordination occasional (7.5%) HP:0002311
25 increased intracranial pressure occasional (7.5%) HP:0002516
26 peritonitis occasional (7.5%) HP:0002586
27 cerebral ischemia occasional (7.5%) HP:0002637
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 paresthesia occasional (7.5%) HP:0003401
31 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 chronic hepatic failure occasional (7.5%) HP:0100626
36 chest pain occasional (7.5%) HP:0100749
37 sepsis occasional (7.5%) HP:0100806
38 benign neoplasm of the central nervous system occasional (7.5%) HP:0100835

Drugs & Therapeutics for Alveolar Echinococcosis

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Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1BenzimidazoleexperimentalPhase 4451-17-25798
2Antiparasitic AgentsPhase 41854
3AnthelminticsPhase 4379
4Anti-Infective AgentsPhase 417220
5Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With BenzimidazolesRecruitingNCT00658294Phase 4
2Long-term Results of Comprehensive AE ManagementCompletedNCT02509884
3Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
4The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the LiverCompletedNCT01785212
5Epi Cystic Hydatid Disease PeruCompletedNCT00138346

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS65/NDF-RT43:

Genetic Tests for Alveolar Echinococcosis

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Anatomical Context for Alveolar Echinococcosis

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MalaCards organs/tissues related to Alveolar Echinococcosis:

33
Liver, Lung, Brain, Bone, Ovary, Skin, T cells

Animal Models for Alveolar Echinococcosis or affiliated genes

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MGI Mouse Phenotypes related to Alveolar Echinococcosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.3CD36, CD8A, HLA-DQB1, MT-CO1, TAP1, TAP2

Publications for Alveolar Echinococcosis

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Articles related to Alveolar Echinococcosis:

(show top 50)    (show all 395)
idTitleAuthorsYear
1
Early versus Delayed Excision and Grafting of Full-Thickness Burns in a Porcine Model: A Randomized Study. (27219266)
2016
2
Molecular and immunologic markers of kidney cancer-potential applications in predictive, preventive and personalized medicine. (26500709)
2015
3
NAT2 slow acetylation genotypes contribute to asthma risk among Caucasians: evidence from 946 cases and 1,091 controls. (24442317)
2014
4
Thrombolytic effects of the snake venom disintegrin saxatilin determined by novel assessment methods: a FeCl3-induced thrombosis model in mice. (24260554)
2013
5
The use of ultrasound during intrauterine insemination in unexplained infertility may improve pregnancy outcomes. (23235295)
2013
6
The major histocompatibility complex: a model for understanding graft-versus-host disease. (23878143)
2013
7
Osteochondroma with metaphyseal abnormalities after total body irradiation followed by stem cell transplantation. (22246151)
2012
8
Patent ductus arteriosus in preterm infants. (23084717)
2012
9
A practical method for reducing blindness due to retinopathy of prematurity in a developing country. (22945278)
2012
10
Value of frozen section examination in diagnosis and treatment of high-grade cervical intraepithelial neoplasia. (22882922)
2012
11
Cauda equina syndrome presenting as abdominal pain: a case report. (21839600)
2012
12
Repeated syncope in a needle man. (23196736)
2012
13
Personalized medicine can pave the way for the safe use of CBa88 receptor antagonists. (21497918)
2011
14
Strategies to maximize expression of rightly processed human interferon alpha2b in Pichia pastoris. (20159042)
2010
15
SUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter. (20382164)
2010
16
Hepatitis B spliced protein (HBSP) generated by a spliced hepatitis B virus RNA participates in abnormality of fibrin formation and functions by binding to fibrinogen I^ chain. (20981788)
2010
17
Resistin up-regulates fractalkine expression in human endothelial cells: lack of additive effect with TNF-alpha. (19351602)
2009
18
Immunohistochemical marker for Na+ CP type Valpha (C-20) and heterozygous nonsense SCN5A mutation W822X in a sudden cardiac death induced by mild anaphylactic reaction. (19318916)
2009
19
Development of lentiviral gene therapy for Wiskott Aldrich syndrome. (18194074)
2008
20
Effect of integrin alpha2beta1 on invasion and migration of neuroblastoma cells]. (18554474)
2008
21
Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene. (18042801)
2008
22
A case of herpes zoster with abducens palsy. (17982243)
2007
23
Microarrays of 41 human tumor cell lines for the characterization of new molecular targets: expression patterns of cathepsin B and the transferrin receptor. (17347587)
2006
24
Toward a multimodal neuroprotective treatment of stroke. (16527996)
2006
25
Laparoscopic environmental changes during surgery enhance the invasive potential of tumours. (15897689)
2005
26
TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. (16106251)
2005
27
Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4. (15031672)
2004
28
Fibroblast invasive migration into fibronectin/fibrin gels requires a previously uncharacterized dermatan sulfate-CD44 proteoglycan. (15009704)
2004
29
General suitability of techniques for in situ detection of apoptosis in small intestinal epithelium. (12740944)
2003
30
Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells. (12207171)
2002
31
Complementary and alternative therapies for the common cold. (11174218)
2001
32
Clinical picture: tuberculous chorioretinitis. (11356435)
2001
33
Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. (11694878)
2001
34
Proofreading of DNA polymerase eta-dependent replication errors. (11113111)
2001
35
Reversal of fortune. Do Rab GTPases act on the target membrane? (10747079)
2000
36
Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3'-untranslated region. (10766797)
2000
37
Effective light-induced hydroxylamine reactions occur with C13 = C14 nonisomerizable bacteriorhodopsin pigments. (9649399)
1998
38
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (9489702)
1998
39
beta Interferon inhibits HIV-1 Tat-induced angiogenesis: synergism with 13-cis retinoic acid. (9713311)
1998
40
Metronidazole and suramin combination in the treatment of arsenical refractory Rhodesian sleeping sickness--a case study. (8882195)
1996
41
Cytokines in human lung fibrosis. (8678788)
1996
42
Pharmacokinetics, efficacy, and safety of analgesia with a focus on tramadol HCl. (8764760)
1996
43
Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization. (7829096)
1994
44
Is ipsilateral testis mandatory for contralateral testicular deterioration encountered following spermatic cord torsion? (7974914)
1994
45
Reanalysis of Hanford data: 1944-1986 deaths. (8503458)
1993
46
Immunodetection of proliferating cell nuclear antigen assesses the growth fraction and predicts malignancy in endocrine tumors of the pancreas. (1281387)
1992
47
Maple syrup urine disease in five hereford calves in ontario. (17422842)
1987
48
Aniridia caused by a heritable chromosome 11 deletion. (230439)
1979
49
Hyperlipoproteinemia and inner ear disease. (4527831)
1974
50
Isovaleric and -methylbutyric acidemias induced by hypoglycin A: mechanism of Jamaican vomiting sickness. (5008580)
1972

Variations for Alveolar Echinococcosis

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Expression for genes affiliated with Alveolar Echinococcosis

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Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for genes affiliated with Alveolar Echinococcosis

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Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show top 27)    (show all 28)
idSuper pathwaysScoreTop Affiliating Genes
19.8HLA-DRB1, TNF
29.7CD36, TNF
3
Show member pathways
9.3CD8A, HLA-A, HLA-DRB1
4
Show member pathways
9.3CD8A, HLA-A, HLA-DRB1
5
Show member pathways
9.3CD8A, HLA-A, TNF
6
Show member pathways
9.2HLA-A, HLA-B, TNF
79.2CD8A, TAP1, TAP2
89.2CD8A, KLRK1, TNF
99.1CD36, KLRK1, TNF
109.1CD36, CD8A, HLA-DRB1, TNF
119.0CD8A, HLA-DQB1, HLA-DRB1
129.0HLA-DQB1, HLA-DRB1, TNF
139.0HLA-DQB1, HLA-DRB1, TNF
14
Show member pathways
9.0HLA-DQB1, HLA-DRB1, TNF
158.7CD36, CD8A, KLRK1, TNF
168.7CD8A, HLA-A, HLA-B, KLRK1
178.6HLA-A, HLA-B, TAP1, TAP2
18
Show member pathways
8.6HLA-A, HLA-B, KLRK1, TNF
19
Show member pathways
8.5HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
208.5HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
21
Show member pathways
8.2CD36, HLA-A, HLA-B, TAP1, TAP2
228.2CD8A, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1
238.1HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, TNF
24
Show member pathways
7.1HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, TAP1, TAP2
257.1CD36, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, TAP1
26
Show member pathways
6.8CD8A, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, TAP1
27
Show member pathways
5.8CD36, CD8A, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Alveolar Echinococcosis

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Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1trans-Golgi network membraneGO:00325889.4HLA-DQB1, HLA-DRB1
2cell surfaceGO:00099868.9CD36, HLA-A, HLA-B
3ER to Golgi transport vesicle membraneGO:00125078.9HLA-A, HLA-DQB1, HLA-DRB1

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood microparticle formationGO:200033410.3CD36, TNF
2positive regulation of T cell mediated cytotoxicityGO:000191610.2HLA-A, HLA-B
3negative regulation of growth of symbiont in hostGO:004413010.2CD36, TNF
4intracellular transport of viral protein in host cellGO:001906010.0TAP1, TAP2
5positive regulation of nitric oxide biosynthetic processGO:004542910.0KLRK1, TNF
6immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.0HLA-DQB1, HLA-DRB1
7peptide transportGO:00158339.9TAP1, TAP2
8protection from natural killer cell mediated cytotoxicityGO:00422709.8HLA-A, HLA-B, TAP1
9positive regulation of interleukin-6 productionGO:00327559.7CD36, TNF
10antigen processing and presentation of endogenous peptide antigen via MHC class IGO:00198859.6HLA-A, TAP1, TAP2
11cell surface receptor signaling pathwayGO:00071669.5CD36, CD8A, TNF
12defense responseGO:00069529.4HLA-B, TAP1, TNF
13adaptive immune responseGO:00022509.2KLRK1, TAP1, TAP2
14immune responseGO:00069559.1CD36, HLA-DRB1, TNF
15cellular response to lipopolysaccharideGO:00712229.1CD36, KLRK1, TNF
16defense response to Gram-positive bacteriumGO:00508309.0CD36, HLA-A, KLRK1, TNF
17antigen processing and presentationGO:00198828.9HLA-A, HLA-B, HLA-DQB1, HLA-DRB1

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TAP1 bindingGO:00469789.6TAP1, TAP2
2tapasin bindingGO:00469809.4TAP1, TAP2
3peptide-transporting ATPase activityGO:00154409.2TAP1, TAP2
4peptide antigen bindingGO:00426059.2HLA-A, HLA-B, TAP1

Sources for Alveolar Echinococcosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet