MCID: ALV002
MIFTS: 50

Alveolar Echinococcosis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Alveolar Echinococcosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 51Orphanet, 65UMLS, 59SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 10 45 51 65
Echinococcosis 45 65
Multilocular Hydatid 10
 
Small Fox Tapeworm 10
Alveolococcosis 10


Classifications:



Characteristics (Orphanet epidemiological data):

51
alveolar echinococcosis:
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly


External Ids:

Disease Ontology10 DOID:12148
ICD9CM29 122.7
Orphanet51 284
SNOMED-CT59 21009004, 240816000
ICD10 via Orphanet28 B67.5, B67.6, B67.7
MESH via Orphanet37 C536591
UMLS via Orphanet66 C0948954

Summaries for Alveolar Echinococcosis

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Disease Ontology:10 An echinococcosis that is caused by the larvae of echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary: Alveolar Echinococcosis, also known as echinococcosis, is related to echinococcosis and hepatitis, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways are Cytokines and Inflammatory Response and Primary immunodeficiency. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Alveolar Echinococcosis

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Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis11.5
2hepatitis11.0
3cerebritis10.7
4cysticercosis10.6
5polycystic echinococcosis10.6
6taeniasis10.5
7budd-chiari syndrome10.5
8cystic echinococcosis10.3
9choroid disease10.3CD8A, HLA-DRB1
10angioid streaks10.3HLA-DRB1, MT-CO1
11best1 retinopathy10.3HLA-DRB1, TNF
12microsomia hemifacial radial defects10.3HLA-DRB1, TNF
13cerebellar astrocytoma10.2CD8A, HLA-DRB1
14wissler's syndrome10.2HLA-B, TNF
15anti-hla hyperimmunization10.2HLA-B, TNF
16hair defect with photosensitivity and mental retardation10.2HLA-B, TNF
17congenital cataract - progressive muscular hypotonia - hearing loss - developmental delay10.2HLA-DRB1, TNF
18hepatic tuberculosis10.2CD8A, TNF
19microsporidiosis10.2HLA-DRB1, TNF
20rhizomelic dysplasia patterson lowry type10.2HLA-DRB1, TNF
21neurotic excoriation10.2CD8A, TNF
22moderately severe hemophilia a10.2HLA-DRB1, TNF
23miliary tuberculosis10.2CD8A, HLA-B
24benign lymphoepithelial lesion of salivary gland10.2CD8A, TNF
25rheumatoid arthritis10.2
26hepatocellular carcinoma10.2
27arthritis10.2
28parametritis10.2
29portal vein thrombosis10.2
30acquired immunodeficiency syndrome10.2
31mediastinitis10.2
32pancreatitis10.2
33peritonitis10.2
34prostatitis10.2
35pulmonary embolism10.2
36hypoxia10.2
37prion disease10.2CD8A, TNF
38thymus basaloid carcinoma10.2HLA-B, TNF
39colitis10.2CD8A, TNF
40lip cancer10.2CD8A, TNF
41melkersson-rosenthal syndrome10.2CD8A, TNF
42jaccoud's syndrome10.2HLA-A, HLA-B
4346 xx gonadal dysgenesis10.2CD36, TNF
44bladder papillary clear cell adenocarcinoma10.2HLA-A, HLA-B
45meninges hemangiopericytoma10.2HLA-A, HLA-B
46anthracosis10.2HLA-A, HLA-B
47congenital heart disease10.2HLA-B, TNF
48monocular esotropia10.2HLA-A, HLA-B
49ocular melanoma10.2CD36, HLA-DRB1
50baritosis10.2HLA-DRB1, TNF

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to alveolar echinococcosis

Symptoms for Alveolar Echinococcosis

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Symptoms:

 51 (show all 45)
  • pruritus/itching
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • polycystic liver disease/hepatic cysts
  • hepatitis/icterus/cholestasis
  • extrahepatic biliary tract atresia/obstruction
  • hepatomegaly/liver enlargement (excluding storage disease)
  • anaemia
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • visual loss/blindness/amblyopia
  • anomalies of spine, vertebrae and pelvis
  • anomalies of skin, subcutaneous tissue and mucosae
  • ascitis
  • esophageal varices
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • peritonitis/peritoneal abscess
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • cirrhosis
  • chronic hepatic failure
  • portal hypertension
  • splenomegaly
  • lung/pulmonary infiltrates
  • thoracic/chest pain
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • abnormal/polycystic ovaries
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • transient cerebral ischemia/stroke
  • cranial hypertension
  • ataxia/incoordination/trouble of the equilibrium
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • elocution disorders/dysarthria/dysphonia
  • muscle anomalies
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone cyst
  • severe allergic reaction/atopy
  • benign tumor of the brain/nervous system
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Alveolar Echinococcosis:

(show all 38)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 weight loss typical (50%) HP:0001824
6 anemia typical (50%) HP:0001903
7 hepatomegaly typical (50%) HP:0002240
8 abnormality of temperature regulation typical (50%) HP:0004370
9 extrahepatic biliary duct atresia typical (50%) HP:0005242
10 polycystic ovaries occasional (7.5%) HP:0000147
11 visual impairment occasional (7.5%) HP:0000505
12 seizures occasional (7.5%) HP:0001250
13 cirrhosis occasional (7.5%) HP:0001394
14 portal hypertension occasional (7.5%) HP:0001409
15 ascites occasional (7.5%) HP:0001541
16 splenomegaly occasional (7.5%) HP:0001744
17 esophageal varix occasional (7.5%) HP:0002040
18 migraine occasional (7.5%) HP:0002076
19 respiratory insufficiency occasional (7.5%) HP:0002093
20 hemoptysis occasional (7.5%) HP:0002105
21 pulmonary infiltrates occasional (7.5%) HP:0002113
22 neurological speech impairment occasional (7.5%) HP:0002167
23 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
24 incoordination occasional (7.5%) HP:0002311
25 increased intracranial pressure occasional (7.5%) HP:0002516
26 peritonitis occasional (7.5%) HP:0002586
27 cerebral ischemia occasional (7.5%) HP:0002637
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 paresthesia occasional (7.5%) HP:0003401
31 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 chronic hepatic failure occasional (7.5%) HP:0100626
36 chest pain occasional (7.5%) HP:0100749
37 sepsis occasional (7.5%) HP:0100806
38 benign neoplasm of the central nervous system occasional (7.5%) HP:0100835

Drugs & Therapeutics for Alveolar Echinococcosis

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Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1BenzimidazoleexperimentalPhase 4451-17-25798
2AnthelminticsPhase 4363

Interventional clinical trials:

idNameStatusNCT IDPhase
1Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With BenzimidazolesRecruitingNCT00658294Phase 4
2Long-term Results of Comprehensive AE ManagementCompletedNCT02509884
3Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
4The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the LiverCompletedNCT01785212
5Epi Cystic Hydatid Disease PeruCompletedNCT00138346

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS65/NDF-RT43:

Genetic Tests for Alveolar Echinococcosis

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Anatomical Context for Alveolar Echinococcosis

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MalaCards organs/tissues related to Alveolar Echinococcosis:

33
Liver, Lung, Brain, Bone, Ovary, Skin, Testes

Animal Models for Alveolar Echinococcosis or affiliated genes

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MGI Mouse Phenotypes related to Alveolar Echinococcosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.2CCL17, CD36, CD8A, HLA-B, KLRK1, TAP2
2MP:00053876.6CCL17, CD36, CD8A, HLA-B, KLRK1, MT-CO1

Publications for Alveolar Echinococcosis

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Articles related to Alveolar Echinococcosis:

(show top 50)    (show all 394)
idTitleAuthorsYear
1
The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis. (26509179)
2015
2
Threat of alveolar echinococcosis to public health - a challenge for Europe. (26115902)
2015
3
Unique MRI findings for differentiation of an early stage of hepatic alveolar echinococcosis. (25697300)
2015
4
Two-yr follow-up of a 12-yr-old girl after living donor liver transplantation due to hepatic alveolar echinococcosis. (26087263)
2015
5
Comparison of the serological tests ICT and ELISA for the diagnosis of alveolar echinococcosis in Francea98. (25058754)
2014
6
Immunodiagnosis of alveolar echinococcosis using urine samples. (23872436)
2013
7
PRIMARY CEREBRAL ALVEOLAR ECHINOCOCCOSIS: MYCOLOGY TO THE RESCUE. (24335950)
2013
8
Alveolar echinococcosis of the adrenal gland: brief review of two cases. (22800838)
2012
9
Mapping the increasing risk of human alveolar echinococcosis in Limburg, The Netherlands. (21733269)
2012
10
An uncommon reason for dyspnoea: phrenic paresis secondary to alveolar echinococcosis. (23024329)
2012
11
Parasite-specific IL-17-type cytokine responses and soluble IL-17 receptor levels in Alveolar Echinococcosis patients. (22969818)
2012
12
Immunochromatographic test with recombinant Em18 antigen for the follow-up study of alveolar echinococcosis. (21715578)
2011
13
Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china. (20042519)
2010
14
Dot immunogold filtration assay (DIGFA) with multiple native antigens for rapid serodiagnosis of human cystic and alveolar echinococcosis. (19836341)
2010
15
Education and Imaging. Hepatobiliary and pancreatic: alveolar echinococcosis mimicking hepatocellular carcinoma. (20928949)
2010
16
Skin fistulization associated with extensive alveolar echinococcosis. (20406585)
2010
17
Giant hepatic alveolar echinococcosis in an adult. (19427628)
2009
18
Research on targeting sources of alveolar echinococcosis in Japan. (17662388)
2007
19
Human alveolar echinococcosis in Slovenia. (17371540)
2007
20
Stereological evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis using computed tomography via the Cavalieri method. (17105589)
2006
21
Socioeconomic and behavior risk factors of human alveolar echinococcosis in Tibetan communities in Sichuan, People's Republic of China. (16687693)
2006
22
Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients. (16879243)
2006
23
Alveolar echinococcosis in the zoological garden Basle. (16315852)
2005
24
Orthotopic liver transplantation for incurable alveolar echinococcosis: report of five cases from west China. (15964373)
2005
25
Secondary and primary murine alveolar echinococcosis: combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity. (15064126)
2004
26
Mediastinal recurrence of alveolar echinococcosis after liver transplantation. (12514779)
2003
27
HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China. (14570623)
2003
28
European echinococcosis registry: human alveolar echinococcosis, Europe, 1982-2000. (12643830)
2003
29
Development of Em18-immunoblot and Em18-ELISA for specific diagnosis of alveolar echinococcosis. (12606094)
2003
30
Evaluation of use of recombinant Em18 and affinity-purified Em18 for serological differentiation of alveolar echinococcosis from cystic echinococcosis and other parasitic infections. (12843091)
2003
31
Alveolar echinococcosis in Turkey. Experience from an endemic region. (12789026)
2003
32
Evaluation of an enzyme-linked immunosorbent assay (ELISA) with affinity-purified Em18 and an ELISA with recombinant Em18 for differential diagnosis of alveolar echinococcosis: results of a blind test. (12409391)
2002
33
Molecular tools for the diagnosis of cystic and alveolar echinococcosis. (11422961)
2001
34
Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature. (10980173)
2000
35
Extrahepatic alveolar echinococcosis without liver involvement: a rare manifestation. (10879649)
2000
36
Hepatic alveolar echinococcosis. A case report. (10335973)
1999
37
Primary disease recurrence after liver transplantation for alveolar echinococcosis: long-term evaluation in 15 patients. (10498634)
1999
38
Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis. (9875648)
1998
39
Cystic and alveolar echinococcosis in Turkey. (9924542)
1998
40
Imaging diagnosis of alveolar echinococcosis in young patients. (8995172)
1997
41
Epidemiology of alveolar echinococcosis in southern Germany (Bavaria). (7622269)
1995
42
Human alveolar echinococcosis seroprevalence assessed by western blotting in Hokkaido. (8531411)
1995
43
Association between HLA-DR13 and susceptibility to alveolar echinococcosis. (8195634)
1994
44
CT in lobar atrophy of the liver caused by alveolar echinococcosis. (1545016)
1992
45
Growing importance of prevention and control of alveolar echinococcosis. (1953939)
1991
46
Application of a recombinant Echinococcus multilocularis antigen in an enzyme-linked immunosorbent assay for immunodiagnosis of human alveolar echinococcosis. (2671725)
1989
47
Orthotopic liver transplantation in alveolar echinococcosis of the liver: analysis of a series of six patients. (2450418)
1988
48
Experimental alveolar echinococcosis. Suitability of a murine model of intrahepatic infection by Echinococcus multilocularis for immunological studies. (6510502)
1984
49
Hepatic alveolar echinococcosis invading pancreas, vertebrae, and spinal cord. (7129411)
1982
50
Immunomorphology and pathogenesis of echinococcosis. III: Microscopic immunofluorescence studies in experimental alveolar echinococcosis. (344225)
1978

Variations for Alveolar Echinococcosis

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Expression for genes affiliated with Alveolar Echinococcosis

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Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for genes affiliated with Alveolar Echinococcosis

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Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7HLA-DRB1, TNF
29.6CD8A, TAP2
39.4CD36, TNF
4
Show member pathways
9.0CD8A, HLA-A, HLA-DRB1
5
Show member pathways
9.0CD8A, HLA-A, HLA-DRB1
68.9HLA-A, HLA-B, HLA-DRB1
78.9CD36, KLRK1, TNF
8
Show member pathways
8.9CD8A, HLA-A, TNF
9
Show member pathways
8.8HLA-A, HLA-B, TNF
108.7CD36, CD8A, HLA-DRB1, TNF
118.7HLA-A, HLA-B, TAP2
128.6CD8A, HLA-A, HLA-B, HLA-DRB1
138.4HLA-A, HLA-B, HLA-DRB1, TNF
148.4CD8A, HLA-A, HLA-B, KLRK1
15
Show member pathways
8.3HLA-A, HLA-B, KLRK1, TNF
16
Show member pathways
8.1CD36, HLA-A, HLA-B, TAP2
17
Show member pathways
7.9HLA-A, HLA-B, HLA-DRB1, TAP2, TNF
187.8CD36, HLA-A, HLA-B, HLA-DRB1, TAP2
19
Show member pathways
7.6CD8A, HLA-A, HLA-B, HLA-DRB1, TAP2, TNF
20
Show member pathways
6.5CD36, CD8A, HLA-A, HLA-B, HLA-DRB1, KLRK1

GO Terms for genes affiliated with Alveolar Echinococcosis

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Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:00426129.9HLA-A, HLA-B
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.4HLA-A, HLA-B, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.3HLA-A, HLA-B, HLA-DRB1
4external side of plasma membraneGO:00098979.1CD36, CD8A, HLA-DRB1, TNF
5cell surfaceGO:00099867.0CD36, CD8A, HLA-A, HLA-B, HLA-DRB1, KLRK1
6integral component of plasma membraneGO:00058876.7CD36, CD8A, HLA-A, HLA-B, HLA-DRB1, KLRK1

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of myoblast differentiationGO:00456629.9CCL17, TNF
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00024809.9HLA-A, HLA-B
3antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:00024869.9HLA-A, HLA-B
4positive regulation of T cell mediated cytotoxicityGO:00019169.8HLA-A, HLA-B
5protection from natural killer cell mediated cytotoxicityGO:00422709.8HLA-A, HLA-B
6negative regulation of growth of symbiont in hostGO:00441309.8CD36, TNF
7positive regulation of interferon-gamma productionGO:00327299.7HLA-A, TNF
8antigen processing and presentation of endogenous peptide antigen via MHC class IGO:00198859.7HLA-A, TAP2
9detection of bacteriumGO:00160459.5HLA-A, HLA-B, HLA-DRB1
10interferon-gamma-mediated signaling pathwayGO:00603339.4HLA-A, HLA-B, HLA-DRB1
11antigen processing and presentationGO:00198829.0CD8A, HLA-A, HLA-B, HLA-DRB1
12positive regulation of ERK1 and ERK2 cascadeGO:00703748.9CCL17, CD36, TNF
13defense response to Gram-positive bacteriumGO:00508308.6CD36, HLA-A, TNF
14regulation of immune responseGO:00507768.4CD8A, HLA-A, HLA-B, KLRK1
15antigen processing and presentation of peptide antigen via MHC class IGO:00024748.3CD36, HLA-A, HLA-B, TAP2
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00024798.3CD36, HLA-A, HLA-B, TAP2
17antigen processing and presentation of exogenous peptide antigen via MHC class IGO:00425908.3CD36, HLA-A, HLA-B, TAP2
18immune responseGO:00069557.8CCL17, CD8A, HLA-A, HLA-B, HLA-DRB1, TNF

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TAP bindingGO:00469779.4HLA-A, HLA-B
2peptide antigen bindingGO:00426058.9HLA-A, HLA-B, HLA-DRB1

Sources for Alveolar Echinococcosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet