MCID: ALV002
MIFTS: 49

Alveolar Echinococcosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Alveolar Echinococcosis

MalaCards integrated aliases for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 72 49 55 14 69
Echinococcus Multilocularis Infection 12 55 69
Echinococcosis 49 69
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

55
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12148
ICD10 32 B67.6 B67.7
ICD9CM 34 122.7
SNOMED-CT 64 21009004 240816000
Orphanet 55 ORPHA284
MESH via Orphanet 42 C536591
UMLS via Orphanet 70 C0948954
ICD10 via Orphanet 33 B67.5 B67.6 B67.7

Summaries for Alveolar Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to echinococcosis and cystic echinococcosis. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Metronidazole and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain.

Wikipedia : 72 Alveolar hydatid disease (AHD), also known as alveolar echinococcosis, alveolar colloid of the liver,... more...

Related Diseases for Alveolar Echinococcosis

Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 echinococcosis 32.3 CCL17 HLA-B HLA-DRB1 MT-CO1 TNF
2 cystic echinococcosis 30.5 HLA-DRB1 MT-CO1
3 rheumatoid arthritis 28.7 HLA-B HLA-DRB1 TLR2 TLR4 TNF
4 malaria 28.1 HLA-A HLA-B HLA-DRB1 MT-CO1 TLR2 TLR4
5 hepatitis 10.8
6 phenytoin or carbamazepine toxicity 10.5 HLA-A HLA-B
7 atrial tachyarrhythmia with short pr interval 10.5 HLA-A HLA-B
8 idiopathic inflammatory myopathy 10.5 HLA-B HLA-DRB1
9 glaucomatocyclitic crisis 10.5 HLA-A HLA-B
10 cerebritis 10.4
11 beryllium disease 10.4 HLA-DRB1 TNF
12 human herpesvirus 8 10.4 HLA-A HLA-B
13 chronic beryllium disease 10.4 HLA-DRB1 TNF
14 autoimmune pancreatitis 10.4 HLA-DRB1 TNF
15 lichen sclerosus 10.4 HLA-DRB1 TNF
16 htlv-1 associated myelopathy/tropical spastic paraparesis 10.4 HLA-A KLRK1
17 paragonimiasis 10.4 CCL17 MT-CO1
18 actinic prurigo 10.4 HLA-DRB1 TNF
19 sympathetic ophthalmia 10.3 HLA-DRB1 TNF
20 microscopic colitis 10.3 HLA-DRB1 TNF
21 central nervous system vasculitis 10.3 HLA-DRB1 TNF
22 rheumatoid vasculitis 10.3 HLA-DRB1 TNF
23 postherpetic neuralgia 10.3 HLA-A HLA-B HLA-DRB1
24 pars planitis 10.3 HLA-A HLA-B HLA-DRB1
25 pityriasis rosea 10.3 HLA-A HLA-B HLA-DRB1
26 histoplasmosis 10.3 HLA-A HLA-B HLA-DRB1
27 pure red-cell aplasia 10.3 HLA-A HLA-B HLA-DRB1
28 paraneoplastic pemphigus 10.3 HLA-A HLA-B HLA-DRB1
29 cytomegalovirus retinitis 10.3 HLA-B TNF
30 vogt-koyanagi-harada disease 10.3 HLA-A HLA-B HLA-DRB1
31 intermediate uveitis 10.2 HLA-B TNF
32 hemorrhagic fever 10.2 HLA-DRB1 TNF
33 palindromic rheumatism 10.2 HLA-A HLA-DRB1 TNF
34 microscopic polyangiitis 10.2 HLA-B HLA-DRB1 TNF
35 dengue shock syndrome 10.2 HLA-A HLA-DRB1 TNF
36 spondylarthropathy 10.2 TLR4 TNF
37 panuveitis 10.2 HLA-B HLA-DRB1 TNF
38 dengue hemorrhagic fever 10.2 HLA-A HLA-DRB1 TNF
39 tympanosclerosis 10.2 TLR4 TNF
40 oligoarticular juvenile idiopathic arthritis 10.2 HLA-DRB1 TNF
41 hematopoietic stem cell transplantation 10.2 HLA-A HLA-B TNF
42 aphthous stomatitis 10.2 HLA-A HLA-B TNF
43 sclerosing cholangitis 10.2 HLA-B HLA-DRB1 TNF
44 spondyloarthropathy 10.2 HLA-A HLA-B TNF
45 cholangitis 10.2 HLA-B HLA-DRB1 TNF
46 rheumatic disease 10.2 HLA-B HLA-DRB1 TNF
47 budd-chiari syndrome 10.2
48 periodontosis 10.2 HLA-A TLR4
49 psoriatic arthritis 10.2 HLA-B HLA-DRB1 TNF
50 cysticercosis 10.1 MT-CO1 TLR4

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis

Symptoms & Phenotypes for Alveolar Echinococcosis

Drugs & Therapeutics for Alveolar Echinococcosis

Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Albendazole Approved, Vet_approved 54965-21-8 2082
3
Mebendazole Approved, Vet_approved 31431-39-7 4030
4 Benzimidazole Experimental, Investigational 51-17-2
5 Antiparasitic Agents
6 Liver Extracts
7 Anthelmintics
8 Anti-Infective Agents
9 Antimitotic Agents
10 Antiprotozoal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Results of Comprehensive AE Management Completed NCT02509884
2 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018
3 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
4 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
5 Epi Cystic Hydatid Disease Peru Completed NCT00138346
6 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
7 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Benzimidazole

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Alveolar Echinococcosis

Anatomical Context for Alveolar Echinococcosis

MalaCards organs/tissues related to Alveolar Echinococcosis:

38
Liver, Lung, Brain, Testes, Adrenal Gland, Skin, Pancreas

Publications for Alveolar Echinococcosis

Articles related to Alveolar Echinococcosis:

(show top 50) (show all 462)
# Title Authors Year
1
Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: First case report in the literature. ( 29391928 )
2018
2
Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. ( 29426481 )
2018
3
Liver transplantation for hepatic alveolar echinococcosis: literature review and three new cases. ( 29363377 )
2018
4
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
5
Removal notice for Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis [JSR 210 (2017) 169-176]. ( 29433881 )
2018
6
Diffusion-Weighted MRI for the Initial Viability Evaluation of Parasites in Hepatic Alveolar Echinococcosis: Comparison with Positron Emission Tomography. ( 29353998 )
2018
7
Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis. ( 28457324 )
2017
8
Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients: Case report. ( 29049181 )
2017
9
Vertebral alveolar echinococcosis-a case report, systematic analysis, and review of the literature. ( 28807628 )
2017
10
Alveolar echinococcosis presenting with simultaneous cerebral and spinal involvement. ( 28554898 )
2017
11
Disseminated alveolar echinococcosis resembling metastatic malignancy: a case report. ( 28416007 )
2017
12
To see or not to see: non-invasive imaging for improved readout of drug treatment trials in the murine model of secondary alveolar echinococcosis. ( 28270242 )
2017
13
Two-stage hepatectomy for multiple giant alveolar echinococcosis. ( 28816980 )
2017
14
Fatal Liver and Lung Alveolar Echinococcosis with Newly Developed Neurologic Symptoms due to the Brain Involvement. ( 28825028 )
2017
15
Differentiation between hepatic alveolar echinococcosis and primary hepatic malignancy with diffusion-weighted magnetic resonance imaging. ( 29110943 )
2017
16
Cystic and alveolar echinococcosis: Successes and continuing challenges. ( 28426657 )
2017
17
Comparison of Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance (MR) Imaging to T1 Mapping in Characterization of Hepatic Alveolar Echinococcosis. ( 29259149 )
2017
18
Potential risk factors associated with human alveolar echinococcosis: Systematic review and meta-analysis. ( 28715408 )
2017
19
Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy. ( 28223729 )
2017
20
FDG-PET/MR Imaging in Alveolar Echinococcosis. ( 28935243 )
2017
21
Combined resection of the right liver lobe and retrohepatic inferior vena cava to treat hepatic alveolar echinococcosis: A case report. ( 28930853 )
2017
22
Management of Advanced Hepatic Alveolar Echinococcosis: Report of 42 Cases. ( 28070011 )
2017
23
Obstructive Hydrocephalus due to Intracerebral Alveolar Echinococcosis. ( 29228350 )
2017
24
A European survey of perendoscopic treatment of biliary complications in patients with alveolar echinococcosis. ( 27788612 )
2017
25
Good outcome following liver transplantation using pericardial-peritoneum window for hepato-atrial anastomosis to overcome advanced hepatic alveolar echinococcosis and secondary Budd-Chiari Syndrome - a case report. ( 28086841 )
2017
26
Screening of antigenic vesicular fluid proteins of Echinococcus multilocularis as potential viability biomarkers to monitor drug response in alveolar echinococcosis patients. ( 28697272 )
2017
27
Detection of Echinococcus multilocularis and other foodborne parasites in fox, cat and dog faeces collected in kitchen gardens in a highly endemic area for alveolar echinococcosis. ( 28748783 )
2017
28
Dogs as victims of their own worms: Serodiagnosis of canine alveolar echinococcosis. ( 28915832 )
2017
29
Alveolar echinococcosis in Germany, 1992-2016. An update based on the newly established national AE database. ( 29090421 )
2017
30
Pulmonary involvement in alveolar echinococcosis. ( 28416238 )
2017
31
Efficacy and safety of ultrasound-guided percutaneous microwave ablation for the treatment of hepatic alveolar echinococcosis: A preliminary study. ( 28682866 )
2017
32
Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions. ( 28542546 )
2017
33
Risk factors and a simple model for predicting bile leakage after radical hepatectomy in patients with hepatic alveolar echinococcosis. ( 29145333 )
2017
34
Enhanced recovery after surgery program in patients from Tibet Plateau undergoing surgeries for hepatic alveolar echinococcosis. ( 29078881 )
2017
35
Novel techniques and preliminary results of ex vivo liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis: A study of 31 cases. ( 29232038 )
2017
36
Multiorgan resection with inferior vena cava reconstruction for hepatic alveolar echinococcosis: A case report and literature review. ( 27281076 )
2016
37
Assessment of Vascularity in Hepatic Alveolar Echinococcosis: Comparison of Quantified Dual-Energy CT with Histopathologic Parameters. ( 26901164 )
2016
38
Analysis of the clinical value of (18)F-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation. ( 26889215 )
2016
39
How to not miss alveolar echinococcosis in hepatic lesions suspicious for cholangiocellular carcinoma. ( 26867903 )
2016
40
Serological validation of an alveolar echinococcosis rat model with a single hepatic lesion. ( 27890868 )
2016
41
Liver Transplantation for Incurable Alveolar Echinococcosis: An Analysis of Patients Hospitalized in Department of Tropical and Parasitic Diseases in Gdynia. ( 27496476 )
2016
42
A Case of Alveolar Echinococcosis Presenting as Cerebral and Spinal Intradural Metastases. ( 27551181 )
2016
43
Hints for control of infection in unique extrahepatic vertebral alveolar echinococcosis. ( 28004258 )
2016
44
Visualization and Pathological Characteristics of Hepatic Alveolar Echinococcosis with Synchrotron-based X-ray Phase Sensitive Micro-tomography. ( 27897249 )
2016
45
Alveolar echinococcosis - a rare disease with differential diagnostic problems. ( 27410758 )
2016
46
Ultrasonographic findings of small lesion of hepatic alveolar echinococcosis. ( 26892870 )
2016
47
Alveolar echinococcosis of the right adrenal gland: a case report and review of the literature. ( 27846915 )
2016
48
Multimodality imaging in diagnosis and management of alveolar echinococcosis: an update. ( 27082120 )
2016
49
Fatal Liver and Lung Alveolar Echinococcosis with Newly Developed Neurologic Symptoms due to the Brain Involvement. ( 28824996 )
2016
50
Current interventional strategy for the treatment of hepatic alveolar echinococcosis. ( 27686694 )
2016

Variations for Alveolar Echinococcosis

Expression for Alveolar Echinococcosis

Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for Alveolar Echinococcosis

Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 HLA-A HLA-B HLA-DRB1 KLRK1 TAP2 TLR2
2
Show member pathways
13.18 HLA-A HLA-B HLA-DRB1 KLRK1 TAP2 TLR2
3
Show member pathways
12.78 HLA-A HLA-B TLR2 TLR4 TNF
4
Show member pathways
12.65 HLA-A HLA-B HLA-DRB1 TAP2 TNF
5
Show member pathways
12.43 HLA-DRB1 TLR2 TLR4 TNF
6
Show member pathways
12.35 HLA-A HLA-B KLRK1 TNF
7
Show member pathways
12.32 HLA-A HLA-B TLR2 TLR4 TNF
8 12.26 HLA-A HLA-B HLA-DRB1 TNF
9
Show member pathways
12.19 HLA-A HLA-B HLA-DRB1 TAP2 TLR2 TLR4
10
Show member pathways
12.17 HLA-A HLA-B TAP2 TLR2 TLR4
11
Show member pathways
12.16 CCL17 TLR2 TNF
12 12.13 HLA-A HLA-B HLA-DRB1
13 12.13 TLR2 TLR4 TNF
14
Show member pathways
12.09 TLR2 TLR4 TNF
15
Show member pathways
12.05 HLA-DRB1 TLR2 TLR4 TNF
16
Show member pathways
12.02 TLR2 TLR4 TNF
17 12.01 TLR2 TLR4 TNF
18 11.99 HLA-DRB1 TLR2 TLR4 TNF
19
Show member pathways
11.98 HLA-A HLA-B TNF
20 11.95 HLA-A HLA-B HLA-DRB1
21 11.91 HLA-A HLA-B KLRK1
22
Show member pathways
11.78 TLR2 TLR4 TNF
23 11.73 TLR2 TLR4 TNF
24 11.53 TLR2 TLR4 TNF
25 11.51 HLA-DRB1 TLR2 TLR4 TNF
26 11.44 TLR2 TLR4 TNF
27 11.35 TLR2 TLR4 TNF
28 11.28 HLA-A HLA-B HLA-DRB1 TAP2 TLR2 TLR4
29 11.2 TLR4 TNF
30 11.15 KLRK1 TLR2 TLR4 TNF
31 11.11 HLA-DRB1 TNF
32 10.94 HLA-A HLA-B TAP2

GO Terms for Alveolar Echinococcosis

Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 HLA-A HLA-B KLRK1 TLR2 TLR4 TNF
2 external side of plasma membrane GO:0009897 9.62 HLA-DRB1 KLRK1 TLR4 TNF
3 intrinsic component of plasma membrane GO:0031226 9.46 TLR2 TLR4
4 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-B HLA-DRB1
5 MHC class I protein complex GO:0042612 9.4 HLA-A HLA-B
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.33 HLA-A HLA-B HLA-DRB1
7 phagocytic vesicle membrane GO:0030670 9.26 HLA-A HLA-B TAP2 TLR2
8 cell surface GO:0009986 9.17 HLA-A HLA-B HLA-DRB1 KLRK1 TLR2 TLR4
9 membrane GO:0016020 10.18 HLA-A HLA-B HLA-DRB1 KLRK1 LBR MT-CO1
10 integral component of membrane GO:0016021 10.07 HLA-A HLA-B HLA-DRB1 KLRK1 LBR MT-CO1

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.93 HLA-A HLA-B HLA-DRB1 TAP2
2 inflammatory response GO:0006954 9.91 CCL17 TLR2 TLR4 TNF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.84 CCL17 TLR4 TNF
4 regulation of immune response GO:0050776 9.83 HLA-A HLA-B KLRK1
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TLR2 TLR4 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.79 KLRK1 TLR4 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.74 KLRK1 TLR2 TNF
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.71 HLA-A HLA-B TAP2
9 interferon-gamma-mediated signaling pathway GO:0060333 9.7 HLA-A HLA-B HLA-DRB1
10 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 TLR2 TLR4
11 positive regulation of interleukin-6 production GO:0032755 9.67 TLR2 TLR4 TNF
12 negative regulation of interferon-gamma production GO:0032689 9.65 HLA-DRB1 TLR4
13 negative regulation of interleukin-6 production GO:0032715 9.65 TLR4 TNF
14 positive regulation of interferon-beta production GO:0032728 9.65 TLR2 TLR4
15 positive regulation of interferon-gamma production GO:0032729 9.65 KLRK1 TLR4 TNF
16 positive regulation of interleukin-12 production GO:0032735 9.64 TLR2 TLR4
17 positive regulation of interleukin-10 production GO:0032733 9.64 TLR2 TLR4
18 negative regulation of myoblast differentiation GO:0045662 9.63 CCL17 TNF
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 KLRK1 TLR4 TNF
20 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 TLR2 TLR4
21 antigen processing and presentation GO:0019882 9.61 HLA-A HLA-B HLA-DRB1
22 I-kappaB phosphorylation GO:0007252 9.6 TLR2 TLR4
23 regulation of cytokine secretion GO:0050707 9.59 TLR2 TLR4
24 T-helper 1 type immune response GO:0042088 9.58 HLA-DRB1 TLR4
25 cellular response to lipoteichoic acid GO:0071223 9.58 TLR2 TLR4
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 TLR2 TLR4 TNF
27 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.56 HLA-A HLA-B
28 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.55 TLR4 TNF
29 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.54 HLA-A HLA-B TAP2
30 protection from natural killer cell mediated cytotoxicity GO:0042270 9.51 HLA-A HLA-B
31 positive regulation of interleukin-8 production GO:0032757 9.5 TLR2 TLR4 TNF
32 immune system process GO:0002376 9.5 HLA-A HLA-B HLA-DRB1 KLRK1 TAP2 TLR2
33 positive regulation of NF-kappaB import into nucleus GO:0042346 9.43 TLR2 TLR4 TNF
34 positive regulation of chemokine production GO:0032722 9.33 TLR2 TLR4 TNF
35 immune response GO:0006955 9.17 CCL17 HLA-A HLA-B HLA-DRB1 TLR2 TLR4

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.46 CCL17 HLA-A HLA-B TLR4
2 lipopolysaccharide binding GO:0001530 9.26 TLR2 TLR4
3 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4
4 peptide antigen binding GO:0042605 8.8 HLA-A HLA-B HLA-DRB1

Sources for Alveolar Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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