MCID: ALV002
MIFTS: 46

Alveolar Echinococcosis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Alveolar Echinococcosis

Aliases & Descriptions for Alveolar Echinococcosis:

Name: Alveolar Echinococcosis 12 50 56 14 69
Echinococcus Multilocularis Infection 12 56 69
Echinococcosis 50 69
Multilocular Hydatid 12
Small Fox Tapeworm 12
Alveolococcosis 12

Characteristics:

Orphanet epidemiological data:

56
alveolar echinococcosis
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Switzerland),<1/1000000 (Poland),1-9/100000 (Austria),<1/1000000 (France); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12148
ICD10 33 B67.6 B67.7
ICD9CM 35 122.7
SNOMED-CT 64 21009004 240816000
Orphanet 56 ORPHA284
MESH via Orphanet 43 C536591
UMLS via Orphanet 70 C0948954
ICD10 via Orphanet 34 B67.6 B67.7 B67.5
UMLS 69 C0152069

Summaries for Alveolar Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

MalaCards based summary : Alveolar Echinococcosis, also known as echinococcus multilocularis infection, is related to hepatitis and rheumatoid arthritis. An important gene associated with Alveolar Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Benzimidazole and Anthelmintics have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotype is immune system.

Related Diseases for Alveolar Echinococcosis

Diseases related to Alveolar Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 hepatitis 31.0 HLA-A HLA-B HLA-DRB1 TNF
2 rheumatoid arthritis 29.0 HLA-DRB1 TLR2 TLR4 TNF
3 echinococcosis 11.7
4 solid pseudopapillary carcinoma of pancreas 10.3 HLA-A HLA-B
5 cerebritis 10.3
6 myopathy, congenital nonprogressive, with moebius sequence and robin sequence 10.3 HLA-A HLA-B
7 epididymo-orchitis 10.3 HLA-A HLA-B
8 immune deficiency, familial variable 10.3 HLA-B HLA-DRB1
9 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DRB1 TNF
10 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DRB1 TNF
11 distal trisomy 14q 10.2 HLA-DRB1 TNF
12 sacral nerve root cysts 10.2 HLA-A HLA-B HLA-DRB1
13 hernia of ovary and fallopian tube 10.2 HLA-A HLA-B HLA-DRB1
14 learning disability 10.2 HLA-A HLA-B HLA-DRB1
15 acanthoma 10.2 HLA-A HLA-B HLA-DRB1
16 renal hypertension 10.2 CCL17 MT-CO1
17 anaerobic meningitis 10.2 HLA-A HLA-B HLA-DRB1
18 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 HLA-DRB1 TNF
19 folinic acid-responsive seizures 10.2 HLA-A HLA-B HLA-DRB1
20 cervical adenoid basal carcinoma 10.2 HLA-B HLA-DRB1
21 kernicterus due to isoimmunization 10.2 HLA-DRB1 TNF
22 mirizzi syndrome 10.2 HLA-B HLA-DRB1 TNF
23 motility-related diarrhea 10.2 HLA-A HLA-DRB1 TNF
24 apple allergy 10.2 CD8A HLA-DRB1
25 swine influenza 10.2 HLA-B HLA-DRB1 TNF
26 patau syndrome 10.2 HLA-A HLA-DRB1 TNF
27 cryptococcosis 10.2 HLA-B HLA-DRB1 TNF
28 autosomal recessive congenital methemoglobinemia 10.2 CCL17 HLA-A HLA-B
29 depressed scar 10.2 HLA-A HLA-DRB1 TNF
30 gonococcal endophthalmia 10.2 HLA-A HLA-B TNF
31 orbital osteomyelitis 10.1 HLA-A HLA-B TNF
32 central nervous system lymphoma 10.1 HLA-A HLA-B TNF
33 acute cholangitis 10.1 HLA-B HLA-DRB1 TNF
34 spondylometaphyseal dysplasia east-african type 10.1 TLR4 TNF
35 bacterial meningitis 10.1 HLA-B HLA-DRB1 TNF
36 steatitis 10.1 CD8A TNF
37 respiratory system disease 10.1 HLA-B HLA-DRB1 TNF
38 low compliance bladder 10.1 TLR4 TNF
39 hepatic encephalopathy 10.1 TAP2 TNF
40 bubonic plague 10.1 HLA-A HLA-B
41 molybdenum cofactor deficiency a 10.1 HLA-B HLA-DRB1 TNF
42 reproductive system disease 10.1 HLA-DRB1 MT-CO1 TLR2
43 hyperoxaluria, primary, type ii 10.1 CD8A TNF
44 clostridium difficile colitis 10.1 HLA-DRB1 TNF
45 pseudoainhum 10.1 TLR2 TLR4
46 budd-chiari syndrome 10.1
47 endogenous depression 10.1 HLA-DRB1 TLR2 TNF
48 handl syndrome 10.1 TLR2 TNF
49 vestibule of mouth cancer 10.1 CD8A TNF
50 immunoglobulin g deficiency 10.1 HLA-DRB1 TLR4 TNF

Graphical network of the top 20 diseases related to Alveolar Echinococcosis:



Diseases related to Alveolar Echinococcosis

Symptoms & Phenotypes for Alveolar Echinococcosis

MGI Mouse Phenotypes related to Alveolar Echinococcosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCL17 CD8A LBR MT-CO1 TAP2 TLR2

Drugs & Therapeutics for Alveolar Echinococcosis

Drugs for Alveolar Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Benzimidazole Experimental Phase 4 51-17-2
2 Anthelmintics Phase 4
3 Anti-Infective Agents Phase 4
4 Antiparasitic Agents Phase 4
5
Piperazine Approved, Vet_approved 110-85-0 4837
6
Mebendazole Approved, Vet_approved 31431-39-7 4030
7
Albendazole Approved, Vet_approved 54965-21-8 2082
8 Liver Extracts
9 Piperazine citrate
10 Antimitotic Agents
11 Antiprotozoal Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Unknown status NCT00658294 Phase 4
2 Long-term Results of Comprehensive AE Management Completed NCT02509884
3 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018
4 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
5 Epi Cystic Hydatid Disease Peru Completed NCT00138346
6 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146

Search NIH Clinical Center for Alveolar Echinococcosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Alveolar Echinococcosis

Anatomical Context for Alveolar Echinococcosis

MalaCards organs/tissues related to Alveolar Echinococcosis:

39
Liver, Lung, Brain, Testes, Skin, Pancreas, Adrenal Gland

Publications for Alveolar Echinococcosis

Articles related to Alveolar Echinococcosis:

(show top 50) (show all 428)
id Title Authors Year
1
Management of Advanced Hepatic Alveolar Echinococcosis: Report of 42 Cases. ( 28070011 )
2017
2
A European survey of perendoscopic treatment of biliary complications in patients with alveolar echinococcosis. ( 27788612 )
2017
3
Good outcome following liver transplantation using pericardial-peritoneum window for hepato-atrial anastomosis to overcome advanced hepatic alveolar echinococcosis and secondary Budd-Chiari Syndrome - a case report. ( 28086841 )
2017
4
Hints for control of infection in unique extrahepatic vertebral alveolar echinococcosis. ( 28004258 )
2016
5
Current interventional strategy for the treatment of hepatic alveolar echinococcosis. ( 27686694 )
2016
6
Alveolar echinococcosis - a rare disease with differential diagnostic problems. ( 27410758 )
2016
7
A Case of Alveolar Echinococcosis Presenting as Cerebral and Spinal Intradural Metastases. ( 27551181 )
2016
8
Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis. ( 26967740 )
2016
9
Serological validation of an alveolar echinococcosis rat model with a single hepatic lesion. ( 27890868 )
2016
10
How to not miss alveolar echinococcosis in hepatic lesions suspicious for cholangiocellular carcinoma. ( 26867903 )
2016
11
Visualization and Pathological Characteristics of Hepatic Alveolar Echinococcosis with Synchrotron-based X-ray Phase Sensitive Micro-tomography. ( 27897249 )
2016
12
Proposal of a computed tomography classification for hepatic alveolar echinococcosis. ( 27053854 )
2016
13
Multimodality imaging in diagnosis and management of alveolar echinococcosis: an update. ( 27082120 )
2016
14
Analysis of the clinical value of (18)F-FDG PET/CT in hepatic alveolar echinococcosis before and after autologous liver transplantation. ( 26889215 )
2016
15
Autochthonous human alveolar echinococcosis in a Hungarian patient. ( 27352256 )
2016
16
Alveolar echinococcosis in Europe and Poland. Threats to humans ( 27837578 )
2016
17
Impact of Safe Distance on Long-Term Outcome After Surgical Therapy of Alveolar Echinococcosis. ( 27822723 )
2016
18
Hepatectomy for patients with alveolar echinococcosis: Long-term follow-up observations of 144 cases. ( 27693514 )
2016
19
Assessment of Vascularity in Hepatic Alveolar Echinococcosis: Comparison of Quantified Dual-Energy CT with Histopathologic Parameters. ( 26901164 )
2016
20
Endoscopic Treatment of Biliary Stenosis in Patients with Alveolar Echinococcosis - Report of 7 Consecutive Patients with Serial ERC Approach. ( 26910822 )
2016
21
Ultrasonographic findings of small lesion of hepatic alveolar echinococcosis. ( 26892870 )
2016
22
Cerebral Alveolar Echinococcosis Concomitant with Liver and Lung Lesions in a Young Adult Patient: Case Report and Literature Review. ( 27905289 )
2016
23
Multiorgan resection with inferior vena cava reconstruction for hepatic alveolar echinococcosis: A case report and literature review. ( 27281076 )
2016
24
Alveolar echinococcosis of the right adrenal gland: a case report and review of the literature. ( 27846915 )
2016
25
Liver Transplantation for Incurable Alveolar Echinococcosis: An Analysis of Patients Hospitalized in Department of Tropical and Parasitic Diseases in Gdynia. ( 27496476 )
2016
26
Efficacy of ultrasound-guided core-needle biopsy in the diagnosis of hepatic alveolar echinococcosis: a retrospective analysis. ( 27101838 )
2016
27
Analysis of contrast-enhanced ultrasound (CEUS) and pathological images of hepatic alveolar echinococcosis (HAE) lesions. ( 27249592 )
2016
28
An Echinococcus multilocularis Antigen B3 Proteoform That Shows Specific Antibody Responses to Active-Stage Alveolar Echinococcosis. ( 26269620 )
2015
29
Description of vertebral and liver alveolar echinococcosis cases in Cynomolgus monkeys (Macaca fascicularis). ( 26263896 )
2015
30
Ex Vivo Liver Resection and Autotransplantation for End-Stage Alveolar Echinococcosis: A Case Series. ( 26460900 )
2015
31
Correction: Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice. ( 26512896 )
2015
32
Liver transplantation for alveolar echinococcosis: Acceptable when necessary but is it preventable? ( 26077173 )
2015
33
Two other hepatic cystic lesions: alveolar echinococcosis and intraductal papillary mucinous tumor of the bile ducts. ( 25905974 )
2015
34
Recurrence of Liver Transplantation Combined With Lung and Diaphragm Resection for Alveolar Echinococcosis: A Case Report. ( 26361699 )
2015
35
Epidemiological analysis of the distribution of cystic and alveolar echinococcosis in Osh Oblast in the Kyrgyz Republic, 2000-2013. ( 26442705 )
2015
36
Alveolar echinococcosis: how knowledgeable are primary care physicians and pharmacists in the Franche-ComtAc region of France? ( 26408591 )
2015
37
Metastatic and prognostic factors in patients with alveolar echinococcosis. ( 26617841 )
2015
38
Role of magnetic resonance spectroscopy and susceptibility weighted imaging in cerebral alveolar echinococcosis. ( 25904955 )
2015
39
Two-yr follow-up of a 12-yr-old girl after living donor liver transplantation due to hepatic alveolar echinococcosis. ( 26087263 )
2015
40
Application of 3D reconstruction for surgical treatment of hepatic alveolar echinococcosis. ( 26401085 )
2015
41
Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice. ( 26352932 )
2015
42
Human cystic and alveolar echinococcosis in the Tibet Autonomous Region (TAR), China. ( 26271332 )
2015
43
Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis. ( 26635448 )
2015
44
Hepatic alveolar echinococcosis. ( 25773697 )
2015
45
Human Alveolar Echinococcosis, Czech Republic, 2007-2014. ( 26583699 )
2015
46
Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis). ( 26260407 )
2015
47
Alveolar echinococcosis with portal vein thrombosis: An unusual cause for liver transplantation. ( 26321526 )
2015
48
The Potential Role of Th9 Cell Related Cytokine and Transcription Factors in Patients with Hepatic Alveolar Echinococcosis. ( 26509179 )
2015
49
Expression of hypoxia-inducible factor-1I+ in the infiltrative belt surrounding hepatic alveolar echinococcosis in rat. ( 25700027 )
2015
50
Efficiency of liposomal albendazole for the treatment of the patients with complex alveolar echinococcosis: a comparative analysis of CEUS, CT, and PET/CT. ( 26239800 )
2015

Variations for Alveolar Echinococcosis

Expression for Alveolar Echinococcosis

Search GEO for disease gene expression data for Alveolar Echinococcosis.

Pathways for Alveolar Echinococcosis

Pathways related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 32)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CD8A HLA-A HLA-B HLA-DRB1 TAP2 TLR2
2
Show member pathways
13.18 CD8A HLA-A HLA-B HLA-DRB1 TAP2 TLR2
3
Show member pathways
12.47 CD8A HLA-A HLA-B HLA-DRB1 TAP2 TNF
4
Show member pathways
12.43 HLA-DRB1 TLR2 TLR4 TNF
5 12.36 CD8A TAP2 TLR2 TNF
6 12.27 HLA-A HLA-B HLA-DRB1 TNF
7
Show member pathways
12.19 HLA-A HLA-B HLA-DRB1 TAP2 TLR2 TLR4
8 12.14 HLA-A HLA-B HLA-DRB1
9 12.13 TLR2 TLR4 TNF
10
Show member pathways
12.1 TLR2 TLR4 TNF
11
Show member pathways
12.08 CD8A HLA-A HLA-B TAP2 TLR2 TLR4
12
Show member pathways
12.05 HLA-DRB1 TLR2 TLR4 TNF
13
Show member pathways
12.03 TLR2 TLR4 TNF
14 12.02 TLR2 TLR4 TNF
15
Show member pathways
12 HLA-A HLA-B TNF
16 11.99 HLA-DRB1 TLR2 TLR4 TNF
17 11.93 CD8A HLA-A HLA-B
18 11.87 CD8A HLA-A HLA-B HLA-DRB1
19
Show member pathways
11.84 CD8A HLA-A HLA-DRB1
20
Show member pathways
11.81 CD8A HLA-A HLA-DRB1
21
Show member pathways
11.8 TLR2 TLR4 TNF
22 11.75 CD8A HLA-DRB1 TNF
23 11.73 TLR2 TLR4 TNF
24 11.58 HLA-DRB1 TLR2 TLR4 TNF
25 11.57 TLR2 TLR4 TNF
26
Show member pathways
11.5 CD8A HLA-A TNF
27 11.44 TLR2 TLR4 TNF
28 11.38 TLR2 TLR4 TNF
29 11.35 TLR2 TLR4 TNF
30 11.28 HLA-A HLA-B HLA-DRB1 TAP2 TLR2 TLR4
31 11.12 HLA-DRB1 TNF
32 10.94 HLA-A HLA-B TAP2

GO Terms for Alveolar Echinococcosis

Cellular components related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 CD8A HLA-A HLA-B TLR2 TLR4 TNF
2 external side of plasma membrane GO:0009897 9.62 CD8A HLA-DRB1 TLR4 TNF
3 intrinsic component of plasma membrane GO:0031226 9.46 TLR2 TLR4
4 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-B HLA-DRB1
5 MHC class I protein complex GO:0042612 9.4 HLA-A HLA-B
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.33 HLA-A HLA-B HLA-DRB1
7 phagocytic vesicle membrane GO:0030670 9.26 HLA-A HLA-B TAP2 TLR2
8 cell surface GO:0009986 9.17 CD8A HLA-A HLA-B HLA-DRB1 TLR2 TLR4
9 integral component of membrane GO:0016021 10.07 CD8A HLA-A HLA-B HLA-DRB1 LBR MT-CO1

Biological processes related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.91 HLA-A HLA-B HLA-DRB1 TAP2
2 inflammatory response GO:0006954 9.88 CCL17 TLR2 TLR4 TNF
3 regulation of immune response GO:0050776 9.82 CD8A HLA-A HLA-B
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.82 CCL17 TLR4 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 TLR2 TLR4 TNF
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.69 HLA-A HLA-B TAP2
7 interferon-gamma-mediated signaling pathway GO:0060333 9.67 HLA-A HLA-B HLA-DRB1
8 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR2 TLR4
9 positive regulation of interferon-beta production GO:0032728 9.64 TLR2 TLR4
10 negative regulation of interferon-gamma production GO:0032689 9.63 HLA-DRB1 TLR4
11 negative regulation of interleukin-6 production GO:0032715 9.63 TLR4 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.63 TLR2 TLR4 TNF
13 positive regulation of interleukin-12 production GO:0032735 9.62 TLR2 TLR4
14 positive regulation of interleukin-10 production GO:0032733 9.62 TLR2 TLR4
15 negative regulation of myoblast differentiation GO:0045662 9.61 CCL17 TNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 TLR2 TLR4 TNF
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.59 TLR2 TLR4
18 I-kappaB phosphorylation GO:0007252 9.58 TLR2 TLR4
19 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.58 HLA-A HLA-B TAP2
20 regulation of cytokine secretion GO:0050707 9.57 TLR2 TLR4
21 T-helper 1 type immune response GO:0042088 9.56 HLA-DRB1 TLR4
22 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.55 HLA-A HLA-B
23 cellular response to lipoteichoic acid GO:0071223 9.54 TLR2 TLR4
24 positive regulation of interleukin-8 production GO:0032757 9.54 TLR2 TLR4 TNF
25 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.52 TLR4 TNF
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.5 TLR2 TLR4 TNF
27 immune system process GO:0002376 9.5 CD8A HLA-A HLA-B HLA-DRB1 TAP2 TLR2
28 protection from natural killer cell mediated cytotoxicity GO:0042270 9.48 HLA-A HLA-B
29 antigen processing and presentation GO:0019882 9.46 CD8A HLA-A HLA-B HLA-DRB1
30 positive regulation of chemokine production GO:0032722 9.43 TLR2 TLR4 TNF
31 immune response GO:0006955 9.23 CCL17 CD8A HLA-A HLA-B HLA-DRB1 TLR2

Molecular functions related to Alveolar Echinococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4
3 peptide antigen binding GO:0042605 8.8 HLA-A HLA-B HLA-DRB1

Sources for Alveolar Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....