Alveolar Rhabdomyosarcoma malady

Wikipedia: Alveolar rhabdomyosarcoma is a type of rhabdomyosarcoma characterized by its appearance, which is...⁴⁴ more...

MalaCards: Alveolar Rhabdomyosarcoma, also known as alveolar childhood rhabdomyosarcoma, is related to pleomorphic rhabdomyosarcoma and botryoid rhabdomyosarcoma. An important gene associated with Alveolar Rhabdomyosarcoma is PAX3 (paired box 3), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Pathway_PA165980050. The drugs cyclophosphamide and dacarbazine and the compounds vincristine and roscovitine have been mentioned in the context of this disorder. Affiliated tissues include lung and t cells, and related mouse phenotypes are respiratory system and normal.

OMIM: 268220

Aliases & Descriptions:

alveolar rhabdomyosarcoma 6 30 8 alveolar childhood rhabdomyosarcoma 6 43 rhabdomyosarcoma, alveolar 33 43 rhabdomyosarcoma alveolar 30 32 alveolar rhabdomyosarcoma (morphologic abnormality) 6

alveolar rhabdomyosarcoma (disorder) 6 pediatric alveolar rhabdomyosarcoma 6 rhabdomyosarcoma 43 arms 30

Disease types for alveolar rhabdomyosarcoma family:

rhabdomyosarcoma 2, alveolar

Diseases related to alveolar rhabdomyosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 696)

id	Related Disease	Score	Top Affiliating Genes
1	pleomorphic rhabdomyosarcoma	33.1	MYOG, PAX7, DES
2	botryoid rhabdomyosarcoma	32.0	MYOG, PAX7, PAX3, FOXO1, DES
3	rhabdomyosarcoma 2, alveolar	31.7	PAX7, PAX3
4	orbit rhabdomyosarcoma	30.5	VIM, MDM2, DES
5	orbit embryonal rhabdomyosarcoma	29.1	MYCN, MYOG, PAX7, PAX3, IGF2, DES
6	ectomesenchymoma	28.8	PAX7, PAX3
7	nephroblastoma	27.5	VIM, PAX3, FOXO1, IGF2, NOV, PDGFRA
8	choroiditis	26.5	VIM, PAX3, MDM2, IGF2, PDGFRA, SYP
9	ring chromosomes	26.4	FGFR1, MDM2, IGF1R
10	craniosynostosis	26.3	FGFR1, FGFR4, IGF1R, PDGFRA
11	adrenocortical carcinoma	26.2	IGF1R, IGF2, IGFBP2, SYP
12	sertoli-leydig cell tumor	26.1	VIM, MYOG, SYP, DES
13	angiosarcoma	25.9	VIM, MYOG, MDM2, CCND1, PDGFRA, DES
14	embryonal sarcoma	25.8	VIM, MYOG, MDM2, DES
15	malignant peripheral nerve sheath tumor	25.6	VIM, MDM2, PDGFRA
16	leydig cell tumor	25.5	VIM, MYOG, IGF2, SYP, DES
17	rhabdomyosarcoma	25.3	RB1, VIM, MYCN, MYOG, MYOZ2, PAX7
18	glioblastoma	25.3	RB1, MYCN, MDM2, IGFBP2, PDGFRA
19	nevus	25.3	VIM, CCND1, SYP, DES
20	rhabdoid tumors	25.1	VIM, IGF1R, IGF2, SYP, DES
21	oligodendroglioma	24.9	RB1, VIM, MDM2, IGFBP2, PDGFRA, SYP
22	pheochromocytoma	24.8	MYCN, CCND1, IGF1R, IGF2, IGFBP2, SYP
23	wilms tumor	24.6	VIM, MYCN, MYOG, PAX3, CCND1, IGF1R
24	anaplastic oligodendroglioma	24.4	RB1, MDM2, IGFBP2, PDGFRA
25	osteosarcoma	24.4	RB1, VIM, MYCN, MYOG, PAX3, FGFR4
26	synovial sarcoma	24.3	VIM, MYCN, MDM2, IGF1R, IGF2, DES
27	leiomyosarcoma	24.2	RB1, VIM, MYOG, MDM2, CCND1, IGF2
28	merkel cell carcinoma	24.2	VIM, PAX5, PDGFRA, SYP
29	chondrosarcoma	24.1	RB1, VIM, MYOG, FGFR1, MDM2, IGF2
30	retinitis	24.1	RB1, VIM, MYCN, PAX3, FGFR1, FGFR4
31	squamous cell carcinoma	24.1	RB1, VIM, MYCN, FGFR4, MDM2, CCND1
32	acute leukemia	24.1	RB1, PAX5, FGFR1, MDM2, CCND1, IGFBP2
33	fibrosarcoma	24.1	RB1, VIM, LCP1, MDM2, CCND1, IGF2
34	brain cancer	23.9	RB1, MYCN, FGFR1, IGFBP2, PDGFRA, SYP
35	non-hodgkin lymphoma	23.9	MYCN, PAX5, FGFR1, MDM2, CCND1
36	muscular dystrophy	23.9	VIM, MYOZ2, PAX7, COL6A3, TTN, DES
37	meningioma	23.7	RB1, VIM, MYCN, FGFR1, MDM2, CCND1
38	myeloproliferative disorder	23.6	RB1, FGFR1, MDM2, IGF2, PDGFRA
39	central nervous system lymphoma	23.5	RB1, PAX5, MDM2, CCND1, PDGFRA
40	b-cell lymphomas	23.5	RB1, MYCN, PAX5, MDM2, CCND1
41	soft tissue sarcoma	23.5	RB1, VIM, MYOG, PAX7, PAX3, FOXO1
42	paraganglioma	23.4	VIM, FGFR1, CCND1, IGF2, SYP
43	acute lymphoblastic leukemia	23.3	RB1, PAX5, LCP1, MDM2, CCND1, IGF2
44	mantle cell lymphoma	23.3	RB1, MYCN, MDM2, CCND1, IGF1R
45	myopathy	23.1	VIM, MYOG, MYOZ2, PAX7, PAX3, FOXO1
46	insulin resistance	23.0	MYOG, FOXO1, FGFR4, CCND1, IGF1R, IGF2
47	neuroblastoma	22.7	RB1, VIM, MYCN, MYOZ2, PAX5, FOXO1
48	medulloblastoma	22.6	RB1, VIM, MYCN, PAX5, PAX3, FOXO1
49	lymphoblastic leukemia	22.6	RB1, MYCN, PAX5, LCP1, FGFR1, MDM2
50	myelodysplastic syndrome	22.6	RB1, FGFR1, MDM2, CCND1, IGF1R, PDGFRA

Clinical features from OMIM: 268220

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cyclophosphamide, dacarbazine, dactinomycin, etoposide, etoposide phosphate, melphalan, melphalan hydrochloride, vincristine, vincristine sulfate

MalaCards organs/tissues related to alveolar rhabdomyosarcoma:

²²

MGI Mouse Phenotypes related to alveolar rhabdomyosarcoma:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.9	CHRNG, PAX3, PAX7, MYOG, MYCN
2	normal phenotype	MP:0002873	8.6	SYP, TTN, PDGFRA, FGFR1, FOXO1, PAX3
3	craniofacial phenotype	MP:0005382	8.5	TTN, PDGFRA, NOV, IGF1R, FOXO1, PAX3
4	no phenotypic analysis	MP:0003012	8.3	SYP, IGF2, FGFR1, FOXO1, PAX3, PAX7
5	embryogenesis phenotype	MP:0005380	8.0	CHRNG, TTN, PDGFRA, MDM2, FGFR1, FOXO1
6	tumorigenesis	MP:0002006	7.4	PDGFRA, IGF1R, CCND1, MDM2, FGFR4, FOXO1
7	mortality/aging	MP:0010768	7.2	CCND1, NOV, PDGFRA, TTN, DES, CHRNG
8	limbs/digits/tail phenotype	MP:0005371	7.1	PDGFRA, NOV, IGF2, IGF1R, MDM2, FGFR1
9	vision/eye phenotype	MP:0005391	7.1	TTN, NOV, IGF2, CCND1, FGFR1, PAX3
10	integument phenotype	MP:0010771	6.5	PDGFRA, IGF2, IGF1R, CCND1, MDM2, FGFR1
11	digestive/alimentary phenotype	MP:0005381	6.5	PDGFRA, IGF2, IGF1R, CCND1, MDM2, FGFR1
12	skeleton phenotype	MP:0005390	6.5	CCND1, IGF1R, IGF2, NOV, TTN, MDM2
13	hematopoietic system phenotype	MP:0005397	5.9	TSN, PDGFRA, NOV, IGFBP2, IGF2, IGF1R
14	muscle phenotype	MP:0005369	5.6	RB1, CHRNG, DES, TTN, PDGFRA, NOV
15	behavior/neurological phenotype	MP:0005386	5.4	IGF2, NOV, PDGFRA, TTN, TSN, DES
16	homeostasis/metabolism phenotype	MP:0005376	5.4	IGF1R, IGF2, NOV, PDGFRA, TTN, DES
17	cardiovascular system phenotype	MP:0005385	5.2	IGF1R, IGF2, IGFBP2, NOV, PDGFRA, TTN
18	growth/size phenotype	MP:0005378	5.1	CCND1, IGF1R, IGF2, NOV, PDGFRA, TTN
19	immune system phenotype	MP:0005387	4.9	IGF1R, IGF2, IGFBP2, NOV, PDGFRA, TTN
20	cellular phenotype	MP:0005384	4.9	CCND1, IGF1R, IGF2, NOV, PDGFRA, TTN
21	nervous system phenotype	MP:0003631	4.9	CCND1, IGF1R, IGF2, PDGFRA, SYP, CHRNG

Articles related to alveolar rhabdomyosarcoma:

(show top 50)    (show all 54)

id	Title	Authors	Year	Affiliating Genes
1	Nephroblastoma overexpressed (NOV/CCN3) gene: a paire d-domain-specific PAX3-FKHR transcription target that promotes survival and mot ility in alveolar rhabdomyosarcoma cells. (21423212)	Zhang Y.... Wang C.	2011	PAX3, NOV, FOXO1
2	PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma. (21882254)	Marshall A.D.... Grosveld G.C.	2011	FGFR4
3	FOXO1-FGFR1 fusion and amplification in a solid varia nt of alveolar rhabdomyosarcoma. (21666686)	Liu J.... de ChadarAcvian J.P.	2011	FGFR1, FOXO1
4	Fusion gene-negative alveolar rhabdomyosarcoma is cli nically and molecularly indistinguishable from embryonal rhabdomyosarcoma. (20351326)	Williamson D.... Delattre O.	2010	PAX3, PAX7, FOXO1
5	Embryonal and alveolar rhabdomyosarcoma of parameningeal sites in adults: a report of 13 cases. (18945709)	Montone K.T.... LiVolsi V.A.	2009	DES, MYOG
6	PAX immunoreactivity identifies alveolar rhabdomyosarcoma. (19145202)	Sullivan L.M.... LeGallo R.D.	2009	PAX5
7	MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wil d-type p53. (19707204)	Canner J.A.... Lin J.	2009	MDM2
8	PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis. (19442434)	Zeng F.Y.... Chen T.	2009	FOXO1
9	Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. (19339268)	Nishijo K.... Keller C.	2009	PAX3, FOXO1
10	Genomic and clinical analyses of 2p24 and 12q13-q14 a mplification in alveolar rhabdomyosarcoma: a report from the Children's Oncolog y Group. (19422036)	Barr F.G.... Gastier-Foster J.M.	2009	DDX1
11	Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall. (18487991)	Bahrami A.... Folpe A.L.	2008	SYP
12	Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma. (18022385)	Kikuchi K.... Hosoi H.	2008	DES, PAX3, MYOG
13	Adult cutaneous alveolar rhabdomyosarcoma on the face diagnosed by the expression of PAX3-FKHR gene fusion transcripts. (18705836)	Nakagawa N.... Yamanishi K.	2008	DES, MYOG
14	Detection of FOXO1 (FKHR) gene break-apart by fluorescence in situ hybridization in formalin-fixed, paraffin-embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation. (18303411)	Mehra S.... Zhang S.	2008	FOXO1
15	Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. (19047133)	Naini S.... Linardic C.M.	2008	FOXO1
16	PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma. (18679424)	Taniguchi E.... Keller C.	2008	PDGFRA
17	Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype. (18386058)	Kohashi K.... Tsuneyoshi M.	2008	RB1
18	Diagnosis of micrometastases of alveolar rhabdomyosarcoma (18540440)	Blizniukov O.P.... Poliakov V.G.	2008	MYOG
19	Pax3-fkhr and pax7-fkhr fusion genes impact outcome of alveolar rhabdomyosarcoma in children. (17613043)	Kazanowska B.... Koscielniak E.	2007	PAX3, PAX7, FOXO1
20	Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminates PAX3-FKHR positive and negative tumors. (16381018)	De Pitta C.... Rosolen A.	2006	CCND1, IGFBP2
21	Alveolar rhabdomyosarcoma of the paranasal sinuses in a 57-year-old woman with 1:16 translocation. (16959712)	Manucha V.... Sun C.C.	2006	MYOG
22	New genetic tactics to model alveolar rhabdomyosarcoma in the mouse. (16140913)	Keller C.... Capecchi M.R.	2005	PAX3, FOXO1
23	Multimodal genetic diagnosis of solid variant alveolar rhabdomyosarcoma. (16337856)	Cerveira N.... Teixeira M.R.	2005	PAX7
24	Solid alveolar rhabdomyosarcoma originating from the urinary bladder in an adult. Diagnostic value of molecular genetics. (15140004)	Lambert I.... Sciot R.	2004	PAX3, FOXO1
25	PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. (12039929)	Sorensen P.H.... Barr F.G.	2002	PAX3, PAX7, FOXO1
26	Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma. (11863357)	Barber T.D.... Friedman T.B.	2002	PAX3
27	Proliferative and apoptotic differences between alveolar rhabdomyosarcoma subtypes: a comparative study of tumors containing PAX3-FKHR or PAX7-FKHR gene fusions. (11496344)	Collins M.H.... Barr F.G.	2001	PAX7
28	Structural analysis of PAX7 rearrangements in alveolar rhabdomyosarcoma. (10700864)	Fitzgerald J.C.... Barr F.G.	2000	PAX3, PAX7, FOXO1
29	PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma. (10439042)	Bennicelli J.L.... Barr F.G.	1999	PAX3, PAX7
30	A genetic analysis of PAX3-FKHR, the oncogene of alveolar rhabdomyosarcoma. (10616906)	Kempf B.E.... Vogt P.K.	1999	PAX3, FOXO1
31	Solid alveolar rhabdomyosarcoma of the thorax in a child. (9543674)	Sartelet H.... Brambilla E.	1998	VIM, DES, TTN
32	Evidence of genetic alterations in chromosome 11 in embryonal and alveolar rhabdomyosarcoma (10095436)	Brinkschmidt C.... Dockhorn-Dworniczak B.	1998	IGF2
33	Alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor. (9052994)	Thulasi R.... Houghton J.A.	1996	IGF1R, MYOZ2
34	Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction. (8875239)	Arden K.C.... Cavenee W.K.	1996	PAX3, FOXO1
35	Novel formation and amplification of the PAX7-FKHR fusion gene in a case of alveolar rhabdomyosarcoma. (8889501)	Weber-Hall S.... Shipley J.	1996	PAX3, PAX7, FOXO1
36	In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma. (8789435)	Barr F.G.... Biegel J.A.	1996	PAX7
37	MDM2 amplification in a primary alveolar rhabdomyosarcoma displaying a t(2;13)(q35;q14). (8751388)	Meddeb M.... Bernheim A.	1996	MDM2
38	Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma. (8643596)	Bennicelli J.L.... Barr F.G.	1996	PAX3, FOXO1
39	Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma. (8634710)	Davis R.J.... Barr F.G.	1995	FOXO1
40	Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization. (7536457)	Biegel J.A.... Shapiro D.N.	1995	FOXO1
41	The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator. (7630639)	Sublett J.E.... Shapiro D.N.	1995	PAX3, FOXO1
42	Genomic organization of the human PAX3 gene: DNA sequence analysis of the region disrupted in alveolar rhabdomyosarcoma. (7782066)	Macina R.A.... Riethman H.C.	1995	PAX3
43	Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains. (7624119)	Bennicelli J.L.... Barr F.G.	1995	PAX3, FOXO1
44	Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma. (8083365)	Shapiro D.N.... Houghton P.J.	1994	IGF1R
45	Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. (8098985)	Barr F.G.... Emanuel B.S.	1993	PAX3
46	Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. (8221646)	Shapiro D.N.... Naeve C.W.	1993	PAX3
47	Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. (8275086)	Galili N.... Barr F.G.	1993	PAX3, FOXO1
48	Molecular and cytogenetic analysis of chromosomal arms 2q and 13q in alveolar rhabdomyosarcoma. (2069913)	Barr F.G.... Emanuel B.S.	1991	ALPI, COL6A3, LCP1
49	N-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS. (2323837)	Dias P.... Kumar S.	1990	MYCN
50	A case of alveolar rhabdomyosarcoma with a chromosoma l translocation, t(2;13)(q37;q14). (2122583)	Nojima T.... Inoue K.	1990	DES

Genes related to alveolar rhabdomyosarcoma according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	PAX3	paired box 3	11.1	Publications, Summaries, Functions
2	XAGE1A	X antigen family, member 1A	11.1	Expressions, Summaries
3	XAGE1B	X antigen family, member 1B	11.1	Expressions, Summaries
4	XAGE1E	X antigen family, member 1E	11.1	Summaries, Expressions
5	XAGE1C	X antigen family, member 1C	11.1	Expressions, Summaries
6	XAGE1D	X antigen family, member 1D	11.1	Expressions, Summaries
7	FOXO1	forkhead box O1	11.1	Summaries, Publications
8	PAX7	paired box 7	11.1	Publications, Summaries
9	MYOG	myogenin (myogenic factor 4)	11.0	Publications
10	NOV	nephroblastoma overexpressed	11.0	Publications
11	TSN	translin	11.0	Publications
12	CHRNG	cholinergic receptor, nicotinic, gamma (muscle)	11.0	Publications
13	ALPI	alkaline phosphatase, intestinal	11.0	Publications
14	ESD	esterase D	11.0	Publications
15	FAM193B	family with sequence similarity 193, member B	11.0
16	ITM2A	integral membrane protein 2A	11.0	Disorders
17	MYOZ2	myozenin 2	11.0	Publications
18	DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4	11.0
19	DES	desmin	11.0	Publications
20	FGFR4	fibroblast growth factor receptor 4	11.0	Publications
21	DDX1	DEAD (Asp-Glu-Ala-Asp) box helicase 1	11.0	Publications
22	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
23	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	11.0	Publications
24	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
25	COL6A3	collagen, type VI, alpha 3	11.0	Publications
26	SYP	synaptophysin	11.0	Publications
27	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
28	TTN	titin	11.0	Publications
29	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
30	PAX5	paired box 5	11.0	Publications
31	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
32	VIM	vimentin	11.0	Publications
33	RB1	retinoblastoma 1	11.0	Publications
34	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
35	IGF1R	insulin-like growth factor 1 receptor	11.0	Publications
36	CCND1	cyclin D1	11.0	Publications

Pathways related to alveolar rhabdomyosarcoma according to GeneDecks:

(show all 42)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.5	FGFR4
2	Pathway_PA16598005034	9.9	FGFR1, FGFR4, PDGFRA
3	Breast Cancer Regulation by Stathmin136	9.7	FGFR4, IGF1R
4	14-3-3 Induced Intracellular Signaling36	9.5	FGFR4, IGF1R, PDGFRA
5	Rac1 Pathway36	9.4	FGFR1, FGFR4, IGF1R
6	Alzheimers Disease Pathway36	9.2	PDGFRA, IGF1R, FGFR4, FGFR1
7	Tyrosine Kinases / Adaptors3	9.0	FGFR1, PDGFRA, IGF1R, FGFR4
8	Bladder cancer20	8.7	CCND1, MDM2, RB1
9	PPAR Pathway36	8.7	PDGFRA, IGF2, IGF1R, FGFR1
10	Development IGF-RI signaling10	8.6	CCND1, IGF1R, IGF2, IGFBP2
11	Development_IGF-1 receptor signaling41	8.6	IGFBP2, IGF2, IGF1R, CCND1
12	Apoptotic Pathways in Synovial Fibroblasts36	8.5	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
13	PTEN Pathway36	8.5	PDGFRA, COL6A3, IGF1R, MDM2, FGFR4, FGFR1
14	ERK5 Signaling36	8.5	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
15	eIF2 Pathway36	8.5	FGFR1, FGFR4, IGF1R, IGF2, PDGFRA
16	Nanog in Mammalian ESC Pluripotency36	8.5	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
17	Nuclear Receptor Activation by Vitamin-A36	8.5	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
18	DHA Signaling36	8.4	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1, FOXO1
19	eNOS Signaling36	8.4	CHRNG, PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
20	p70S6K Signaling36	8.3	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
21	Activation of PKC through GPCR36	8.3	FGFR1, FGFR4, IGF1R, IGF2, PDGFRA
22	Glioma20	8.3	PDGFRA, IGF1R, CCND1, MDM2, RB1
23	Intracellular Calcium Signaling36	8.3	CHRNG, PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
24	Paxillin Interactions36	8.2	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
25	p53 Mediated Apoptosis36	8.2	PDGFRA, IGF2, IGF1R, MDM2, FGFR4, FGFR1
26	Renin-Angiotensin Pathway36	8.2	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
27	Ras Pathway36	8.2	FGFR1, FGFR4, IGF1R, IGF2, PDGFRA
28	Mitochondrial Apoptosis36	8.2	PDGFRA, IGF2, IGF1R, MDM2, FGFR4, FGFR1
29	Cellular Apoptosis Pathway36	8.1	PDGFRA, IGF2, IGF1R, MDM2, FGFR4, FGFR1
30	Phospholipase-C Pathway36	8.1	PDGFRA, COL6A3, IGF2, IGF1R, FGFR4, FGFR1
31	Rap1 Pathway36	8.1	FGFR1, FGFR4, IGF1R, IGF2, PDGFRA
32	Telomerase Components in Cell Signaling36	8.1	PDGFRA, IGF2, IGF1R, FGFR4, FGFR1, RB1
33	Glioblastoma Multiforme36	8.1	PDGFRA, IGF2, IGF1R, MDM2, FOXO1, RB1
34	Estrogen Pathway36	8.0	PDGFRA, IGF2, IGF1R, CCND1, FGFR4, FGFR1
35	Melanoma20	8.0	PDGFRA, IGF1R, CCND1, MDM2, FGFR1, RB1
36	Prostate cancer20	7.9	RB1, PDGFRA, IGF1R, CCND1, MDM2, FGFR1
37	Pathways in cancer20	7.8	PDGFRA, IGF1R, CCND1, MDM2, FGFR1, FOXO1
38	Rho Family GTPases36	7.6	DES, PDGFRA, COL6A3, IGF2, IGF1R, FGFR4
39	Akt Signaling36	7.5	PDGFRA, IGF2, IGF1R, CCND1, MDM2, FGFR4
40	ILK Signaling36	7.3	PDGFRA, COL6A3, IGF2, IGF1R, CCND1, FGFR4
41	Pancreatic Adenocarcinoma36	7.1	PDGFRA, IGF2, IGF1R, CCND1, MDM2, FGFR4
42	Molecular Mechanisms of Cancer36	6.9	PDGFRA, COL6A3, IGF2, IGF1R, CCND1, MDM2

Compounds related to alveolar rhabdomyosarcoma according to GeneDecks:

(show top 50)    (show all 79)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.6	MYCN
2	roscovitine32	10.1	VIM
3	su 666842	10.0	PDGFRA, FGFR4, FGFR1
4	s 10032	9.8	VIM, SYP, DES
5	pd 17307432 42	10.8	CCND1, FGFR4, FGFR1
6	h2o232	9.2	DES, SYP, IGF1R
7	Insulin recombinant9 9	10.2	RB1, IGF1R, NOV
8	Insulin, porcine9 9	9.9	NOV, IGF1R, RB1
9	etoposide32 42 9 9	11.8	IGF1R, MDM2, MYCN, RB1
10	p00232	8.7	DES, IGFBP2, IGF2, MDM2, RB1
11	glyceraldehyde 3-phosphate32	8.6	IGFBP2, IGF1R, MDM2, FGFR1, MYOG, MYCN
12	n-(4-hydroxyphenyl)retinamide32	8.5	IGF2, CCND1, VIM, RB1
13	formaldehyde32 18	9.5	DES, SYP, ESD, IGFBP2, CCND1, VIM
14	acetylcholine32 9 18 9	11.4	DES, SYP, TTN, IGF1R, MYOZ2, MYOG
15	progestin32	8.0	DES, IGFBP2, IGF2, IGF1R, CCND1, VIM
16	cysteine32	8.0	TTN, NOV, IGF2, IGF1R, MDM2, FGFR1
17	gefitinib32 34 9 9	11.0	IGF2, IGF1R, CCND1, MDM2, VIM
18	phosphotyrosine32	8.0	SYP, PDGFRA, IGF2, IGF1R, FGFR4, FGFR1
19	calcitriol32 42 9 18 9	11.9	PDGFRA, IGFBP2, IGF2, IGF1R, PAX5, RB1
20	dihydrotestosterone32 9 18 9	10.8	DES, IGFBP2, IGF2, IGF1R, VIM
21	forskolin32 42 9 9	10.8	SYP, IGFBP2, IGF2, IGF1R, FGFR1, MYOG
22	adriamycin32	7.7	DES, IGF1R, CCND1, MDM2, MYCN, VIM
23	imatinib32 34 9 9	10.7	DES, PDGFRA, IGF2, IGF1R, CCND1, MDM2
24	doxorubicin32 34 9 9	10.6	DES, IGF1R, CCND1, MDM2, MYCN, VIM
25	butyrate32	7.6	ALPI, IGF2, IGF1R, CCND1, MYOG, VIM
26	adenylate32	7.5	DES, ESD, IGF2, IGF1R, CCND1, FGFR1
27	bromodeoxyuridine32	7.5	DES, IGFBP2, IGF1R, CCND1, FGFR1, MYOG
28	rapamycin32 42	8.5	PDGFRA, IGF2, IGF1R, MDM2, FOXO1, MYOG
29	actinomycin d32	7.4	DES, IGF2, IGF1R, MDM2, MYCN, VIM
30	creatinine32	7.3	DES, SYP, TTN, ALPI, IGF2, IGF1R
31	cycloheximide32	7.3	IGFBP2, IGF2, IGF1R, CCND1, MDM2, FOXO1
32	genistein32 9 18 9	10.3	SYP, IGF1R, CCND1, MDM2, FGFR1, MYCN
33	ly29400232	7.2	IGFBP2, IGF2, IGF1R, CCND1, MDM2, FGFR1
34	paclitaxel32 34 9 9	10.1	IGF2, IGF1R, CCND1, MDM2, FGFR1, VIM
35	agar32	7.0	IGF2, IGF1R, CCND1, MDM2, FGFR1, MYCN
36	glycogen32 18	7.9	DES, SYP, TTN, IGFBP2, IGF2, IGF1R
37	thymidine32 18	7.9	DES, PDGFRA, IGFBP2, IGF2, IGF1R, CCND1
38	phosphatidylinositol32	6.6	PDGFRA, ALPI, IGFBP2, IGF2, IGF1R, CCND1
39	steroid32	6.2	IGF1R, IGF2, IGFBP2, SYP, DES, CCND1
40	progesterone32 42 9 18 9	10.2	IGF1R, IGF2, IGFBP2, SYP, DES, CCND1
41	retinoic acid32 42 18	8.2	DES, SYP, PDGFRA, IGFBP2, IGF2, IGF1R
42	estradiol32 9 18 9	9.1	DES, SYP, IGFBP2, IGF2, IGF1R, CCND1
43	calcium32 9 18 9	8.9	SYP, TTN, PDGFRA, ALPI, IGFBP2, IGF1R
44	paraffin32	5.8	RB1, DES, SYP, PDGFRA, IGF2, IGF1R
45	estrogen32	5.7	IGF1R, IGF2, IGFBP2, PDGFRA, SYP, DES
46	testosterone32 9 18 9	8.7	CCND1, IGF1R, IGF2, IGFBP2, SYP, DES
47	oligonucleotide32	5.5	CCND1, IGF1R, IGF2, IGFBP2, PDGFRA, TSN
48	vegf32	5.5	IGF1R, IGF2, IGFBP2, PDGFRA, SYP, DES
49	tyrosine32	5.1	CCND1, IGF1R, IGF2, IGFBP2, ESD, PDGFRA
50	serine32	5.1	CCND1, IGF1R, IGF2, IGFBP2, TTN, SYP

Biological processes related to alveolar rhabdomyosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of phospholipase C activity	GO:010863	9.8	FGFR1, PDGFRA
2	muscle filament sliding	GO:030049	9.4	VIM, TTN, DES
3	fibroblast growth factor receptor signaling pathway	GO:008543	9.1	MDM2, FGFR4, FGFR1, FOXO1
4	phosphatidylinositol-mediated signaling	GO:048015	8.6	FOXO1, FGFR1, MDM2, IGF1R, PDGFRA
5	insulin receptor signaling pathway	GO:008286	8.5	IGF2, IGF1R, FGFR4, FGFR1, FOXO1
6	positive regulation of cell proliferation	GO:008284	7.8	PDGFRA, IGF2, IGF1R, MDM2, FGFR4, FGFR1

Molecular functions related to alveolar rhabdomyosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	fibroblast growth factor-activated receptor activity	GO:005007	9.7	FGFR1, FGFR4
2	protein tyrosine kinase activity	GO:004713	8.7	TTN, IGF1R, FGFR4, FGFR1
3	identical protein binding	GO:042802	7.6	VIM, LCP1, FGFR1, MDM2, IGF1R, TTN
4	protein binding	GO:005515	4.5	IGF1R, IGF2, IGFBP2, DDX1, PDGFRA, TTN