ARMS
MCID: ALV004
MIFTS: 51

Alveolar Rhabdomyosarcoma (ARMS) malady

Summaries for Alveolar Rhabdomyosarcoma

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Alveolar rhabdomyosarcoma is a type of rhabdomyosarcoma characterized by its appearance, which is... more...

MalaCards: Alveolar Rhabdomyosarcoma, also known as rhabdomyosarcoma alveolar, is related to rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Alveolar Rhabdomyosarcoma is PAX3 (paired box 3). The compounds fatty acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone, and related mouse phenotypes are muscle and behavior/neurological.

Description from OMIM:46 268220

Aliases & Classifications for Alveolar Rhabdomyosarcoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

alveolar rhabdomyosarcoma 8 42 10 60
rhabdomyosarcoma alveolar 42 22 44
alveolar childhood rhabdomyosarcoma 8 60
pediatric alveolar rhabdomyosarcoma 8
rhabdomyosarcoma, alveolar 46
arms 42


External Ids:

Disease Ontology8 DOID:4051
NCIt39 C3749
SNOMED-CT56 404053004, 63449009
OMIM46 268220

Related Diseases for Alveolar Rhabdomyosarcoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Alveolar Rhabdomyosarcoma family:

Rhabdomyosarcoma 2, Alveolar

Diseases related to Alveolar Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 781)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.9PAX7, FOXO1, DES, MYOZ2, MYOG, NOV
2embryonal rhabdomyosarcoma31.0PAX7, PAX3, MYOG, DES
3sarcoma30.7FOXO1, DES, MYOG, FGFR4, PAX3, PAX7
4adenocarcinoma30.3XAGE1D
5melanoma30.3PAX7, PAX3, XAGE1D, FGFR4, DES
6rhabdomyosarcoma 2, alveolar30.3PAX7, PAX3
7nephroblastoma30.0NOV
8osteosarcoma30.0PAX3
9alveolar soft part sarcoma30.0MYOG, DES
10breast cancer30.0NOV, FGFR4, FOXO1
11prostate cancer29.9XAGE1D, FGFR4, FOXO1
12chondrosarcoma29.7DES
13peripheral primitive neuroectodermal tumor29.5DES, MYOG, XAGE1D, PAX3, PAX7
14myopathy29.5PAX7, MYOG, MYOZ2, DES
15orbit alveolar rhabdomyosarcoma10.6
16breast rhabdomyosarcoma10.6
17orbit rhabdomyosarcoma10.5
18leukemia10.4
19lymphedema10.3
20acute leukemia10.3
21cerebritis10.3
22pancreatitis10.3
23primary ciliary dyskinesia10.3
24lymphangiosarcoma10.3
25thoracic outlet syndrome10.2
26chromosomal disease10.2
27beckwith-wiedemann syndrome10.2
28muscular atrophy10.2
29small cell sarcoma10.2
30disseminated intravascular coagulation10.2
31mediastinitis10.2
32spinal muscular atrophy10.2
33hemiplegia10.2
34cri-du-chat syndrome10.2
35squamous cell carcinoma10.2
36complex regional pain syndrome10.1
37chromosome 5p duplication10.1
38syringomyelia10.1
39measles10.1
40chromosome 18p duplication10.1
41chromosome 9 inversion10.1
42essential tremor10.1
43facioscapulohumeral muscular dystrophy10.1
44hepatitis10.1
45colorectal cancer10.1
46wolf-hirschhorn syndrome10.1
47compartment syndrome10.1
48hypertension10.1
49lung cancer10.1
50neuroblastoma10.1

Graphical network of the top 20 diseases related to Alveolar Rhabdomyosarcoma:



Diseases related to alveolar rhabdomyosarcoma

Clinical Features for Alveolar Rhabdomyosarcoma

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

268220

Drugs & Therapeutics for Alveolar Rhabdomyosarcoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alveolar Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Alveolar Rhabdomyosarcoma

Search NIH Clinical Center for Alveolar Rhabdomyosarcoma

Search CenterWatch for Alveolar Rhabdomyosarcoma

Genetic Tests for Alveolar Rhabdomyosarcoma

About this section
Sources:
22GTR
See all sources

Genetic tests related to Alveolar Rhabdomyosarcoma:

id Genetic test Affiliating Genes
1 Rhabdomyosarcoma Alveolar22

Anatomical Context for Alveolar Rhabdomyosarcoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Alveolar Rhabdomyosarcoma:

32
Lung, Breast, Bone, Bone marrow, Cervix, Skin, Brain, Testes, Lymph node, Uterus, Pancreas, Endothelial, Myeloid, Ovary, Thyroid, Skeletal muscle, Heart, T cells

Animal Models for Alveolar Rhabdomyosarcoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Alveolar Rhabdomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.7PAX7, PAX3, MYOZ2, CHRNG, FOXO1
2MP:00053869.6DES, CHRNG, MYOG, NOV, PAX3, PAX7

Publications for Alveolar Rhabdomyosarcoma

About this section
Sources:
50PubMed
See all sources

Articles related to Alveolar Rhabdomyosarcoma:

(show top 50)    (show all 359)
idTitleAuthorsYear
1
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. (24334454)
2014
2
Alveolar ethmoidal rhabdomyosarcoma in a young adult male. (23476011)
2013
3
HPA1 and components of the hedgehog signaling pathway are increased in untreated alveolar orbital rhabdomyosarcoma. (23777428)
2013
4
Too much AKT turns PAX3-FKHR dead: a prospect of novel therapeutic strategy for alveolar rhabdomyosarcoma. (23165483)
2012
5
FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. (22648271)
2012
6
An English Translation of Joseph Luc Riopelle, MD, (HA'tel-Dieu of MontrAcal), and Jean Paul ThAcriault (HA'pital GAcnAcral of Verdun, QuAcbec, Canada): Sur une forme mAcconnue de sarcome des parties molles: le rhabdomyosarcome alvAcolaire (concerning an unrecognized form of sarcoma of the soft tissues: alveolar rhabdomyosarcoma). annales d'anatomie pathologique 1956;1:88-111. (23153096)
2012
7
Alveolar rhabdomyosarcoma with multiple distal metastases. A case report and review of literature. (22948994)
2012
8
Extensive alveolar-type paranasal sinus and orbit rhabdomyosarcoma with intracranial invasion treated successfully. (21421211)
2011
9
Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state. (21493592)
2011
10
Prognostic value of PAX-FKHR fusion status in alveolar rhabdomyosarcoma: a report from the cooperative soft tissue sarcoma study group (CWS). (21254373)
2011
11
IFN-beta restricts tumor growth and sensitizes alveolar rhabdomyosarcoma to ionizing radiation. (20197402)
2010
12
Fusion-negative alveolar rhabdomyosarcoma: modification of risk stratification is premature. (20697086)
2010
13
PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis. (19442434)
2009
14
Alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation: report of 3 cases. (18611935)
2009
15
Alveolar rhabdomyosarcoma of the paranasal sinuses. (20614299)
2008
16
Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma. (18377424)
2008
17
Diagnosis of micrometastases of alveolar rhabdomyosarcoma]. (18540440)
2008
18
Fine needle aspiration cytolog of perineal alveolar rhabdomyosarcoma: cytohistopathologic and immunocytochemical correlations. (17536540)
2007
19
Pax3-fkhr and pax7-fkhr fusion genes impact outcome of alveolar rhabdomyosarcoma in children. (17613043)
2007
20
Global gene expression profiling of PAX-FKHR fusion-positive alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas. (17471488)
2007
21
Characterization, anticancer drug susceptibility and atRA-induced growth inhibition of a novel cell line (HUMEMS) established from pleural effusion of alveolar rhabdomyosarcoma of breast tissue. (17547718)
2007
22
Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma. (16651427)
2006
23
A case of alveolar rhabdomyosarcoma of the ethmoid sinus invading the orbit in an adult. (16768194)
2006
24
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. (15520281)
2004
25
Alveolar rhabdomyosarcoma metastatic to the breast. (12658266)
2003
26
Disseminated alveolar rhabdomyosarcoma in a child with spinal muscular atrophy. (12218605)
2002
27
Fine-needle aspiration biopsy of alveolar rhabdomyosarcoma of the parotid: a case report and review of the literature. (11285621)
2001
28
Structural analysis of PAX7 rearrangements in alveolar rhabdomyosarcoma. (10700864)
2000
29
A novel and consistent amplicon at 13q31 associated with alveolar rhabdomyosarcoma. (10825007)
2000
30
Massive disseminated intravascular coagulation and hyperfibrinolysis in alveolar rhabdomyosarcoma: case report and review of the literature. (10466447)
1999
31
Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. (9823299)
1998
32
Novel formation and amplification of the PAX7-FKHR fusion gene in a case of alveolar rhabdomyosarcoma. (8889501)
1996
33
The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator. (7630639)
1995
34
Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization. (7536457)
1995
35
Alveolar rhabdomyosarcoma of the lung in a child. (8583337)
1995
36
Solid alveolar rhabdomyosarcoma of the hand in adolescence: a clinical, histologic, immunologic, and ultrastructural study. (8747583)
1995
37
Alveolar rhabdomyosarcoma that metastasized to the orbit. (8155037)
1993
38
Alveolar rhabdomyosarcoma: a case presentation. (1457307)
1992
39
Variant translocations of chromosome 13 in alveolar rhabdomyosarcoma. (1777415)
1991
40
Mediastinal involvement by alveolar rhabdomyosarcoma: evaluation with computerized tomography. (2068643)
1991
41
Alveolar rhabdomyosarcoma--a case report. (3223793)
1988
42
Alveolar rhabdomyosarcoma of the larynx: case report and literature review. (3546986)
1987
43
RMZ: a new cell line from a human alveolar rhabdomyosarcoma. In vitro expression of embryonic myosin. (3801282)
1986
44
Glycosphingolipids of an alveolar rhabdomyosarcoma and normal human muscle. A case study. (6536879)
1984
45
The ultrastructure of alveolar and embryonal rhabdomyosarcoma. A correlative light and electron microscopic study of 17 cases. (6541858)
1984
46
Alveolar rhabdomyosarcoma: a cytogenetic and correlated cytological and histological study. (7148452)
1982
47
Alveolar rhabdomyosarcoma associated with disseminated intravascular coagulation and a unique factor VIII antigen. (6807236)
1982
48
Alveolar rhabdomyosarcoma of the greater omentum: a case report. (7444668)
1980
49
Alveolar rhabdomyosarcoma involving the heart. An echocardiographic, angiographic and pathologic study. (975481)
1976
50
Alveolar rhabdomyosarcoma: with long-term survival. (4760316)
1973

Genetic Variations for Alveolar Rhabdomyosarcoma

About this section

Expression for genes affiliated with Alveolar Rhabdomyosarcoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alveolar Rhabdomyosarcoma

Search GEO for disease gene expression data for Alveolar Rhabdomyosarcoma.

Pathways for genes affiliated with Alveolar Rhabdomyosarcoma

About this section

Compounds for genes affiliated with Alveolar Rhabdomyosarcoma

About this section
Sources:
44Novoseek
See all sources

Compounds related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fatty acid4410.0ALPI, MYOG, DES, FOXO1
2tyrosine449.4ESD, FOXO1, DES, MYOZ2, MYOG, FGFR4

GO Terms for genes affiliated with Alveolar Rhabdomyosarcoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:04866310.3PAX7, PAX3
2spinal cord association neuron differentiationGO:02152710.0PAX7, PAX3

Products for genes affiliated with Alveolar Rhabdomyosarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alveolar Rhabdomyosarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet