ARMS
MCID: ALV004
MIFTS: 51

Alveolar Rhabdomyosarcoma (ARMS) malady

Summaries for Alveolar Rhabdomyosarcoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Alveolar rhabdomyosarcoma is a type of rhabdomyosarcoma characterized by its appearance, which is... more...

MalaCards: Alveolar Rhabdomyosarcoma, also known as rhabdomyosarcoma alveolar, is related to rhabdomyosarcoma 2, alveolar and adenocarcinoma. An important gene associated with Alveolar Rhabdomyosarcoma is PAX3 (paired box 3). The compounds fatty acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and brain, and related mouse phenotypes are muscle and behavior/neurological.

Description from OMIM:47 268220

Aliases & Classifications for Alveolar Rhabdomyosarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 22GTR, 45Novoseek, 47OMIM, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

alveolar rhabdomyosarcoma 8 43 10 61
rhabdomyosarcoma alveolar 43 22 45
alveolar childhood rhabdomyosarcoma 8 61
pediatric alveolar rhabdomyosarcoma 8
rhabdomyosarcoma, alveolar 47
arms 43


External Ids:

Disease Ontology8 DOID:4051
NCIt40 C3749
SNOMED-CT57 404053004, 63449009
OMIM47 268220

Related Diseases for Alveolar Rhabdomyosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Alveolar Rhabdomyosarcoma family:

rhabdomyosarcoma 2, alveolar

Diseases related to Alveolar Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 733)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma 2, alveolar30.5PAX7, PAX3
2adenocarcinoma30.3XAGE1D
3alveolar soft part sarcoma30.1MYOG, DES
4wilms tumor29.9DES, MYOG, NOV
5orbit alveolar rhabdomyosarcoma10.6
6breast rhabdomyosarcoma10.6
7short syndrome10.4
8acute leukemia10.4
9soft tissue sarcoma10.4
10primary ciliary dyskinesia10.3
11lymphangiosarcoma10.3
12thoracic outlet syndrome10.2
13beckwith-wiedemann syndrome10.2
14muscular atrophy10.2
15small cell sarcoma10.2
16spinal muscular atrophy10.2
17desmoplastic small round cell tumor10.2
18squamous cell carcinoma10.2
19chromosome 5p duplication10.2
20tremor10.2
21syringomyelia10.1
22measles10.1
23chromosome 18p duplication10.1
24chromosome 9 inversion10.1
25essential tremor10.1
26facioscapulohumeral muscular dystrophy10.1
27colorectal cancer10.1
28mental retardation10.1
29hepatitis c10.1
30hepatitis a10.1
31pallister-killian mosaic syndrome10.1
32spasticity10.1
33age related macular degeneration10.1
34brachial plexus lesion10.1
35diphtheria10.1
36spindle cell rhabdomyosarcoma10.1
37multinodular goiter10.1
38acute myeloid leukemia10.1
39mixed type rhabdomyosarcoma10.1
40ovary rhabdomyosarcoma10.1
41mediastinum rhabdomyosarcoma10.1
42bone lymphoma10.1
43duchenne muscular dystrophy10.1
44hypercalcemia10.1
45n syndrome10.1
46graves' disease10.1
47gliosarcoma10.1
48bone ewing's sarcoma10.1
49synovial sarcoma10.1
50thrombocytopenia10.1

Graphical network of the top 20 diseases related to Alveolar Rhabdomyosarcoma:



Diseases related to alveolar rhabdomyosarcoma

Clinical Features for Alveolar Rhabdomyosarcoma

Sources:
47OMIM
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Clinical features from OMIM:

268220

Drugs & Therapeutics for Alveolar Rhabdomyosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Alveolar Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Alveolar Rhabdomyosarcoma

Search NIH Clinical Center for Alveolar Rhabdomyosarcoma

Search CenterWatch for Alveolar Rhabdomyosarcoma

Genetic Tests for Alveolar Rhabdomyosarcoma

Sources:
22GTR
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Genetic tests related to Alveolar Rhabdomyosarcoma:

id Genetic test Affiliating Genes
1 Rhabdomyosarcoma Alveolar22

Anatomical Context for Alveolar Rhabdomyosarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Alveolar Rhabdomyosarcoma:

33
Bone marrow, Lymph node, Brain, Spinal cord, Heart, Skeletal muscle, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Uterus, Cervix, Myeloid, T cells, Endothelial, Uterus corpus

Animal Models for Alveolar Rhabdomyosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Alveolar Rhabdomyosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.7PAX7, PAX3, MYOZ2, CHRNG, FOXO1
2MP:00053869.6DES, CHRNG, MYOG, NOV, PAX3, PAX7

Publications for Alveolar Rhabdomyosarcoma

Sources:
51PubMed
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Articles related to Alveolar Rhabdomyosarcoma:

(show top 50)    (show all 360)
idTitleAuthorsYear
1
Bone marrow metastases from alveolar rhabdomyosarcoma with impressive FDG PET/CT finding but less-revealing bone scintigraphy. (24152640)
2013
2
Anterior mediastinal alveolar rhabdomyosarcoma in an infant: rare site for a common paediatric tumour. (24088592)
2013
3
The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx). (24213577)
2013
4
Alveolar rhabdomyosarcoma arising in a giant congenital melanocytic nevus in an adult--case report with review of literature. (23451914)
2013
5
Alveolar rhabdomyosarcoma with breast involvement. (23489824)
2013
6
Primary alveolar rhabdomyosarcoma: a horrendous presentation with miraculous remission. (23230255)
2012
7
Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old. (24269390)
2012
8
Caruncular alveolar rhabdomyosarcoma in a woman previously treated for breast cancer. (22893093)
2012
9
Gliosarcoma with alveolar rhabdomyosarcoma-like component: report of a case with a hitherto undescribed sarcomatous component. (23121030)
2012
10
RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas. (22752028)
2012
11
FOXO1-FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma. (21666686)
2011
12
Preclinical testing of erlotinib in a transgenic alveolar rhabdomyosarcoma mouse model. (21559212)
2011
13
Diagnosis of alveolar rhabdomyosarcoma in effusion cytology: a diagnostic pitfall. (19843149)
2010
14
Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma. (20818440)
2010
15
Cytologic, histologic, and immunohistochemical features of maxillofacial alveolar rhabdomyosarcoma in a juvenile dog. (19645742)
2010
16
Alveolar rhabdomyosarcoma of the extremity and nodal metastasis: Is the in-transit lymphatic system at risk? (19711439)
2009
17
MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. (19707204)
2009
18
Pathology quiz case 2. Alveolar rhabdomyosarcoma. (18936365)
2008
19
Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. (19047133)
2008
20
Solid variant of alveolar rhabdomyosarcoma mimicking non-Hodgkin lymphoma: case report and review of literature. (19011478)
2008
21
Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinoma. (18469707)
2008
22
Adult cutaneous alveolar rhabdomyosarcoma on the face diagnosed by the expression of PAX3-FKHR gene fusion transcripts. (18705836)
2008
23
Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma. (16729016)
2006
24
Alveolar rhabdomyosarcoma of the paranasal sinuses in a 57-year-old woman with 1:16 translocation. (16959712)
2006
25
Poor outcome of two children with relapsed state stage IV alveolar rhabdomyosarcoma after allogeneic stem cell transplantation. (16251176)
2005
26
Lack of effective T-lymphocyte response to the PAX3/FKHR translocation area in alveolar rhabdomyosarcoma. (15838707)
2005
27
Lymphadenopathic form of alveolar rhabdomyosarcoma: A case report. (15185604)
2004
28
Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. (15024701)
2004
29
Solid alveolar rhabdomyosarcoma originating from the urinary bladder in an adult. Diagnostic value of molecular genetics. (15140004)
2004
30
Pilot trial of tumor-specific peptide vaccination and continuous infusion interleukin-2 in patients with recurrent Ewing sarcoma and alveolar rhabdomyosarcoma: an inter-institute NIH study. (11836714)
2002
31
Cell division cycle control in embryonal and alveolar rhabdomyosarcomas. (12441266)
2002
32
Alveolar rhabdomyosarcoma of the limb in a sheep. (11505851)
2001
33
Temporary remission of an alveolar rhabdomyosarcoma diagnosed and treated as acute leukemia. (10674913)
2000
34
Alveolar rhabdomyosarcoma of paranasal sinus with cervical metastasis-a case report. (23119659)
2000
35
An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene. (10866659)
2000
36
Response to "Increased creatine kinase MB and cardiac troponin T with normal cardiac troponin I in metastatic alveolar rhabdomyosarcoma". (10702539)
2000
37
A genetic analysis of PAX3-FKHR, the oncogene of alveolar rhabdomyosarcoma. (10616906)
1999
38
Solid alveolar rhabdomyosarcoma of the thorax in a child. (9543674)
1998
39
Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells. (9405676)
1997
40
Translin recognition site sequences flank chromosome translocation breakpoints in alveolar rhabdomyosarcoma cell lines. (9294613)
1997
41
Alveolar rhabdomyosarcoma of the lip in an infant. (8614378)
1996
42
Alveolar soft-part sarcoma: a new type of rhabdomyosarcoma? (8202647)
1994
43
Alveolar rhabdomyosarcoma in a child with diffuse bone marrow involvement and chromosomal translocation (2;13) (1467173)
1992
44
Jejunoileal alveolar rhabdomyosarcoma. A case report. (1342201)
1992
45
Chromosomal sublocalization of the 2;13 translocation breakpoint in alveolar rhabdomyosarcoma. (1382566)
1992
46
Metabolism of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 by blood derived macrophages from a patient with alveolar rhabdomyosarcoma during short-term culture and 1 alpha,25-dihydroxyvitamin D3 after long-term culture. (2009222)
1991
47
Prognostic factors of alveolar rhabdomyosarcoma in childhood. An International Society of Pediatric Oncology study. (2065269)
1991
48
Case report 292. Diagnosis: alveolar rhabdomyosarcoma, metastatic to the right femur, primary site undetermined. (6239379)
1984
49
Alveolar rhabdomyosarcoma of the eyelid. Diagnosis by electron microscopy. (5032735)
1972
50
Alveolar rhabdomyosarcoma; a distinctive tumor type. (13533329)
1958

Genetic Variations for Alveolar Rhabdomyosarcoma

Expression for genes affiliated with Alveolar Rhabdomyosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alveolar Rhabdomyosarcoma

Search GEO for disease gene expression data for Alveolar Rhabdomyosarcoma.

Pathways for genes affiliated with Alveolar Rhabdomyosarcoma

Compounds for genes affiliated with Alveolar Rhabdomyosarcoma

Sources:
45Novoseek
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Compounds related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fatty acid4510.0ALPI, MYOG, DES, FOXO1
2tyrosine459.4ESD, FOXO1, DES, MYOZ2, MYOG, FGFR4

GO Terms for genes affiliated with Alveolar Rhabdomyosarcoma

Sources:
16Gene Ontology
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Biological processes related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:04866310.3PAX7, PAX3
2spinal cord association neuron differentiationGO:02152710.0PAX7, PAX3

Products for genes affiliated with Alveolar Rhabdomyosarcoma

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Sources for Alveolar Rhabdomyosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet