ARMS
MCID: ALV004
MIFTS: 51

Alveolar Rhabdomyosarcoma (ARMS) malady

Summaries for Alveolar Rhabdomyosarcoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Alveolar rhabdomyosarcoma is a type of rhabdomyosarcoma characterized by its appearance, which is... more...

MalaCards: Alveolar Rhabdomyosarcoma, also known as rhabdomyosarcoma alveolar, is related to rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Alveolar Rhabdomyosarcoma is PAX3 (paired box 3). The compounds fatty acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and bone, and related mouse phenotypes are muscle and behavior/neurological.

Description from OMIM:46 268220

Aliases & Classifications for Alveolar Rhabdomyosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 22GTR, 44Novoseek, 46OMIM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

alveolar rhabdomyosarcoma 8 42 10 60
rhabdomyosarcoma alveolar 42 22 44
alveolar childhood rhabdomyosarcoma 8 60
pediatric alveolar rhabdomyosarcoma 8
rhabdomyosarcoma, alveolar 46
arms 42


External Ids:

Disease Ontology8 DOID:4051
NCIt39 C3749
SNOMED-CT56 404053004, 63449009
OMIM46 268220

Related Diseases for Alveolar Rhabdomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Alveolar Rhabdomyosarcoma family:

Rhabdomyosarcoma 2, Alveolar

Diseases related to Alveolar Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 781)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.9PAX7, FOXO1, DES, MYOZ2, MYOG, NOV
2embryonal rhabdomyosarcoma31.0PAX7, PAX3, MYOG, DES
3sarcoma30.7FOXO1, DES, MYOG, FGFR4, PAX3, PAX7
4adenocarcinoma30.3XAGE1D
5melanoma30.3PAX7, PAX3, XAGE1D, FGFR4, DES
6rhabdomyosarcoma 2, alveolar30.3PAX7, PAX3
7nephroblastoma30.0NOV
8osteosarcoma30.0PAX3
9alveolar soft part sarcoma30.0MYOG, DES
10breast cancer30.0NOV, FGFR4, FOXO1
11prostate cancer29.9XAGE1D, FGFR4, FOXO1
12chondrosarcoma29.7DES
13peripheral primitive neuroectodermal tumor29.5DES, MYOG, XAGE1D, PAX3, PAX7
14myopathy29.5PAX7, MYOG, MYOZ2, DES
15orbit alveolar rhabdomyosarcoma10.6
16breast rhabdomyosarcoma10.6
17orbit rhabdomyosarcoma10.5
18leukemia10.4
19lymphedema10.3
20acute leukemia10.3
21cerebritis10.3
22pancreatitis10.3
23primary ciliary dyskinesia10.3
24lymphangiosarcoma10.3
25thoracic outlet syndrome10.2
26chromosomal disease10.2
27beckwith-wiedemann syndrome10.2
28muscular atrophy10.2
29small cell sarcoma10.2
30disseminated intravascular coagulation10.2
31mediastinitis10.2
32spinal muscular atrophy10.2
33hemiplegia10.2
34cri-du-chat syndrome10.2
35squamous cell carcinoma10.2
36complex regional pain syndrome10.1
37chromosome 5p duplication10.1
38syringomyelia10.1
39measles10.1
40chromosome 18p duplication10.1
41chromosome 9 inversion10.1
42essential tremor10.1
43facioscapulohumeral muscular dystrophy10.1
44hepatitis10.1
45colorectal cancer10.1
46wolf-hirschhorn syndrome10.1
47compartment syndrome10.1
48hypertension10.1
49lung cancer10.1
50neuroblastoma10.1

Graphical network of the top 20 diseases related to Alveolar Rhabdomyosarcoma:



Diseases related to alveolar rhabdomyosarcoma

Clinical Features for Alveolar Rhabdomyosarcoma

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46OMIM
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Clinical features from OMIM:

268220

Drugs & Therapeutics for Alveolar Rhabdomyosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alveolar Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Alveolar Rhabdomyosarcoma

Search NIH Clinical Center for Alveolar Rhabdomyosarcoma

Search CenterWatch for Alveolar Rhabdomyosarcoma

Genetic Tests for Alveolar Rhabdomyosarcoma

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22GTR
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Genetic tests related to Alveolar Rhabdomyosarcoma:

id Genetic test Affiliating Genes
1 Rhabdomyosarcoma Alveolar22

Anatomical Context for Alveolar Rhabdomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Alveolar Rhabdomyosarcoma:

32
Lung, Breast, Bone, Bone marrow, Cervix, Brain, Skin, Testes, Lymph node, Heart, Myeloid, Uterus, Ovary, Thyroid, Pancreas, Skeletal muscle, Endothelial, T cells

Animal Models for Alveolar Rhabdomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alveolar Rhabdomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.7PAX7, PAX3, MYOZ2, CHRNG, FOXO1
2MP:00053869.6DES, CHRNG, MYOG, NOV, PAX3, PAX7

Publications for Alveolar Rhabdomyosarcoma

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50PubMed
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Articles related to Alveolar Rhabdomyosarcoma:

(show top 50)    (show all 359)
idTitleAuthorsYear
1
Regulation of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma. (23645752)
2013
2
A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma. (23432728)
2013
3
Nasopharyngeal alveolar rhabdomyosarcoma expressing CD56: a mimicker of extranodal natural killer/T-cell lymphoma. (24427371)
2013
4
Dynamic and nuclear expression of PDGFRI+ and IGF-1R in alveolar Rhabdomyosarcoma. (23928059)
2013
5
Survival following disease recurrence of primary localized alveolar rhabdomyosarcoma. (23418028)
2013
6
The over-expression of cell migratory genes in alveolar rhabdomyosarcoma could contribute to metastatic spread. (22415709)
2012
7
PAX3-FKHR regulates the expression of pleiotrophin to mediate motility in alveolar rhabdomyosarcoma cells. (24348888)
2012
8
The impact of age on outcome of embryonal and alveolar rhabdomyosarcoma patients. A multicenter study. (23060577)
2012
9
2D-difference gel electrophoretic proteomic analysis of a cell culture model of alveolar rhabdomyosarcoma. (21110518)
2011
10
Alveolar rhabdomyosarcoma originating from the uterine cervix. (21614913)
2011
11
Genomic and clinical analysis of amplification of the 13q31 chromosomal region in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. (21220470)
2011
12
Pure alveolar rhabdomyosarcoma of the uterine corpus. (21615615)
2011
13
Treatment results for patients with localized, completely resected (Group I) alveolar rhabdomyosarcoma on Intergroup Rhabdomyosarcoma Study Group (IRSG) protocols III and IV, 1984-1997: a report from the Children's Oncology Group. (20806360)
2010
14
Leukaemic alveolar rhabdomyosarcoma. (20813011)
2010
15
Laryngeal alveolar rhabdomyosarcoma involving the true vocal fold in an adult: Case report. (21174270)
2010
16
Glycogen synthase kinase 3 regulates PAX3-FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. (19995556)
2010
17
Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. (19339268)
2009
18
Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. (19422036)
2009
19
Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell? (19008039)
2009
20
Manifestation of alveolar rhabdomyosarcoma as primary cutaneous lesions in a neonate with Beckwith-Wiedemann syndrome. (19302842)
2009
21
PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma. (18679424)
2008
22
Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype. (18386058)
2008
23
Alveolar rhabdomyosarcoma mimicking nasal lymphoma at the initial presentation. (19039198)
2008
24
Pelvic alveolar rhabdomyosarcoma with bone marrow involvement misdiagnosed as acute myeloid leukemia. (17454783)
2007
25
Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. (17527077)
2007
26
Synchronous bifocal alveolar rhabdomyosarcoma: a case report. (16799004)
2006
27
Assessing the use of FDG-PET in the detection of regional and metastatic nodes in alveolar rhabdomyosarcoma of extremities. (16825990)
2006
28
A metastatic alveolar rhabdomyosarcoma of the hand. (16200631)
2006
29
Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminates PAX3-FKHR positive and negative tumors. (16381018)
2006
30
Pediatric malignancies. Case 1. Hypermethylation in orbital alveolar rhabdomyosarcoma. (16034055)
2005
31
Multimodal genetic diagnosis of solid variant alveolar rhabdomyosarcoma. (16337856)
2005
32
Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimens. (15536621)
2004
33
Immune-mediated thrombocytopenia following dactinomycin therapy in a child with alveolar rhabdomyosarcoma: the unresolved issues. (15543019)
2004
34
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. (12039929)
2002
35
Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma. (11863357)
2002
36
Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. (11807989)
2002
37
Congenital alveolar rhabdomyosarcoma: clinical and molecular distinction from alveolar rhabdomyosarcoma in older children. (11169945)
2001
38
Use of reverse transcriptase polymerase chain reaction for diagnosis and staging of alveolar rhabdomyosarcoma, Ewing sarcoma family of tumors, and desmoplastic small round cell tumor. (11216714)
2001
39
Alveolar rhabdomyosarcoma involving the jaws: a case report. (10981991)
2000
40
Diagnosis of disseminated alveolar rhabdomyosarcoma using cytogenetics: case report. (10065215)
1998
41
Long-lasting complete remission after prolonged administration of etoposide in a child with a second recurrence of alveolar rhabdomyosarcoma. (8986152)
1997
42
Alveolar rhabdomyosarcoma of the uterine cervix. (8946879)
1996
43
Solid alveolar rhabdomyosarcoma with a t(2;13). (7736424)
1995
44
Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. (8221646)
1993
45
Molecular and cytogenetic analysis of chromosomal arms 2q and 13q in alveolar rhabdomyosarcoma. (2069913)
1991
46
Alveolar rhabdomyosarcoma of the vulva. Report of two cases. (2042436)
1991
47
Chromosome translocation (2;13)(q37;q14) in a disseminated alveolar rhabdomyosarcoma. (3197735)
1988
48
Exfoliative cytopathology of alveolar rhabdomyosarcoma. (3630701)
1987
49
Alveolar rhabdomyosarcoma of the female genitalia. (4016676)
1985
50
Alveolar rhabdomyosarcoma presenting as subacute intravascular coagulation. (886020)
1977

Genetic Variations for Alveolar Rhabdomyosarcoma

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Expression for genes affiliated with Alveolar Rhabdomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alveolar Rhabdomyosarcoma

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Pathways for genes affiliated with Alveolar Rhabdomyosarcoma

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Compounds for genes affiliated with Alveolar Rhabdomyosarcoma

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44Novoseek
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Compounds related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fatty acid4410.0ALPI, MYOG, DES, FOXO1
2tyrosine449.4ESD, FOXO1, DES, MYOZ2, MYOG, FGFR4

GO Terms for genes affiliated with Alveolar Rhabdomyosarcoma

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16Gene Ontology
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Biological processes related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:04866310.3PAX7, PAX3
2spinal cord association neuron differentiationGO:02152710.0PAX7, PAX3

Products for genes affiliated with Alveolar Rhabdomyosarcoma

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Sources for Alveolar Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet