ARMS
MCID: ALV004
MIFTS: 50

Alveolar Rhabdomyosarcoma (ARMS) malady

Rare diseases, Cancer diseases categories
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Summaries for Alveolar Rhabdomyosarcoma

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Wikipedia:65 Alveolar rhabdomyosarcoma is a type of rhabdomyosarcoma characterized by its appearance, which is... more...

MalaCards based summary: Alveolar Rhabdomyosarcoma, also known as rhabdomyosarcoma alveolar, is related to rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Alveolar Rhabdomyosarcoma is PAX3 (paired box 3), and among its related pathways are Neural Crest Differentiation and Transcriptional misregulation in cancer. Affiliated tissues include lung, breast and bone, and related mouse phenotypes are respiratory system and tumorigenesis.

Description from OMIM:46 268220

Aliases & Classifications for Alveolar Rhabdomyosarcoma

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Alveolar Rhabdomyosarcoma, Aliases & Descriptions:

Name: Alveolar Rhabdomyosarcoma 8 42 10 62
Rhabdomyosarcoma Alveolar 42 22 44
Alveolar Childhood Rhabdomyosarcoma 8 62
 
Pediatric Alveolar Rhabdomyosarcoma 8
Rhabdomyosarcoma, Alveolar 46
Arms 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:4051
SNOMED-CT57 63449009, 404053004
OMIM46 268220
NCIt39 C3749

Related Diseases for Alveolar Rhabdomyosarcoma

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Diseases in the Alveolar Rhabdomyosarcoma family:

Rhabdomyosarcoma 2, Alveolar

Diseases related to Alveolar Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.7NOV, PAX3, PAX7
2embryonal rhabdomyosarcoma30.8PAX7, PAX3
3sarcoma30.6FGFR4, PAX3, PAX7
4orbit alveolar rhabdomyosarcoma10.5
5leukemia10.4
6sinusitis10.4
7acute leukemia10.3
8cerebritis10.3
9pancreatitis10.3
10desmoplastic small round cell tumor10.3
11soft tissue sarcoma10.3
12beckwith-wiedemann syndrome10.2
13spinal muscular atrophy10.2
14muscular atrophy10.2
15disseminated intravascular coagulation10.2
16mediastinitis10.2
17thyroiditis10.2
18rhabdomyosarcoma 2, alveolar10.2
19age related macular degeneration10.1
20acute myeloid leukemia10.1
21duchenne muscular dystrophy10.1
22non-hodgkin lymphoma10.1
23thrombocytopenia10.1
24hypercalcemia10.1
25multinodular goiter10.1
26graves' disease10.1
27jejunoileitis10.1
28neuronitis10.1
29mixed type rhabdomyosarcoma10.1
30brachial plexus lesion10.1
31alveolar soft part sarcoma10.1
32nasopharyngitis10.1
33gliosarcoma10.1
34diphtheria10.1
35breast cancer10.1
36cervicitis10.1
37ethmoid sinusitis10.1
38goiter10.1
39hepatoblastoma10.1
40hydrocele10.1
41laryngitis10.1
42muscular dystrophy10.1
43myeloid leukemia10.1
44nephroblastoma10.1
45neuroblastoma10.1
46osteosarcoma10.1
47pleomorphic rhabdomyosarcoma10.1
48synovial sarcoma10.1
49multiple endocrine neoplasia type 2a10.1
50multiple endocrine neoplasia10.1

Graphical network of the top 20 diseases related to Alveolar Rhabdomyosarcoma:



Diseases related to alveolar rhabdomyosarcoma

Symptoms for Alveolar Rhabdomyosarcoma

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Clinical features from OMIM:

268220

Drugs & Therapeutics for Alveolar Rhabdomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Alveolar Rhabdomyosarcoma

Search NIH Clinical Center for Alveolar Rhabdomyosarcoma

Genetic Tests for Alveolar Rhabdomyosarcoma

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Genetic tests related to Alveolar Rhabdomyosarcoma:

id Genetic test Affiliating Genes
1 Rhabdomyosarcoma Alveolar22

Anatomical Context for Alveolar Rhabdomyosarcoma

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MalaCards organs/tissues related to Alveolar Rhabdomyosarcoma:

32
Lung, Breast, Bone, Bone marrow, Cervix, Brain, Skin, Thyroid, Testes, Lymph node, Heart, Skeletal muscle, Pancreas, Ovary, Uterus, Myeloid, T cells

Animal Models for Alveolar Rhabdomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Alveolar Rhabdomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9PAX7, PAX3, CHRNG, FGFR4
2MP:00020068.7PMAIP1, PAX7, PAX3, FGFR4
3MP:00053828.6NOV, PAX3, PAX7
4MP:00053698.5PAX7, PAX3, CHRNG, NOV
5MP:00053868.3PAX7, PAX3, CHRNG, NOV
6MP:00053878.2NOV, PAX3, PAX7, PMAIP1
7MP:00053787.9FGFR4, NOV, CHRNG, PAX3, PAX7
8MP:00053847.8FGFR4, NOV, PAX3, PAX7, PMAIP1
9MP:00107687.5FGFR4, NOV, CHRNG, PAX3, PAX7, PMAIP1

Publications for Alveolar Rhabdomyosarcoma

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Articles related to Alveolar Rhabdomyosarcoma:

(show top 50)    (show all 346)
idTitleAuthorsYear
1
Alveolar rhabdomyosarcoma of the tunica vaginalis presenting as a tender hydrocele. (24099115)
2013
2
Therapeutic cytodifferentiation in alveolar rhabdomyosarcoma without genetic change of the PAX3-FKHR chimeric fusion gene: a case study. (23797277)
2013
3
Severe acute rhabdomyolysis induced by multi-agent chemotherapy for alveolar rhabdomyosarcoma in a 15-year-old female: a case report. (24019778)
2013
4
Too much AKT turns PAX3-FKHR dead: a prospect of novel therapeutic strategy for alveolar rhabdomyosarcoma. (23165483)
2012
5
Primary alveolar rhabdomyosarcoma: a horrendous presentation with miraculous remission. (23230255)
2012
6
The over-expression of cell migratory genes in alveolar rhabdomyosarcoma could contribute to metastatic spread. (22415709)
2012
7
PAX3-FKHR regulates the expression of pleiotrophin to mediate motility in alveolar rhabdomyosarcoma cells. (24348888)
2012
8
Oral low-dose chemotherapy: successful treatment of an alveolar rhabdomyosarcoma during pregnancy. (22076833)
2012
9
Primary cutaneous alveolar rhabdomyosarcoma in a pediatric patient. (21603825)
2011
10
2D-difference gel electrophoretic proteomic analysis of a cell culture model of alveolar rhabdomyosarcoma. (21110518)
2011
11
Alveolar rhabdomyosarcoma originating from the uterine cervix. (21614913)
2011
12
Alveolar rhabdomyosarcoma of vulva. (20090257)
2010
13
IFN-beta restricts tumor growth and sensitizes alveolar rhabdomyosarcoma to ionizing radiation. (20197402)
2010
14
Solid variant of alveolar rhabdomyosarcoma in the head and neck region: a case report of a diagnostic dilemma in a head and neck fine needle aspiration clinic. (21053554)
2010
15
Metastatic alveolar rhabdomyosarcoma in multiple endocrine neoplasia type 2A. (20533522)
2010
16
Unusual leptomeningeal dissemination in a child with extracranial metastatic alveolar rhabdomyosarcoma. (19657999)
2009
17
Embryonal and alveolar rhabdomyosarcoma of parameningeal sites in adults: a report of 13 cases. (18945709)
2009
18
Alveolar rhabdomyosarcoma of the extremity and nodal metastasis: Is the in-transit lymphatic system at risk? (19711439)
2009
19
Pathology quiz case 2. Alveolar rhabdomyosarcoma. (18936365)
2008
20
Alveolar rhabdomyosarcoma of the paranasal sinuses. (20614299)
2008
21
Alveolar rhabdomyosarcoma of the left hand with bilateral breast metastases in an adolescent female. (19114329)
2008
22
Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. (19047133)
2008
23
Fine needle aspiration cytolog of perineal alveolar rhabdomyosarcoma: cytohistopathologic and immunocytochemical correlations. (17536540)
2007
24
Synchronous bifocal alveolar rhabdomyosarcoma: a case report. (16799004)
2006
25
Pediatric malignancies. Case 1. Hypermethylation in orbital alveolar rhabdomyosarcoma. (16034055)
2005
26
Poor outcome of two children with relapsed state stage IV alveolar rhabdomyosarcoma after allogeneic stem cell transplantation. (16251176)
2005
27
Lymphadenopathic form of alveolar rhabdomyosarcoma: A case report. (15185604)
2004
28
Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions. (12183429)
2002
29
Pilot trial of tumor-specific peptide vaccination and continuous infusion interleukin-2 in patients with recurrent Ewing sarcoma and alveolar rhabdomyosarcoma: an inter-institute NIH study. (11836714)
2002
30
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. (12039929)
2002
31
Association of alveolar rhabdomyosarcoma with the Beckwith-Wiedemann syndrome. (11826361)
2001
32
Temporary remission of an alveolar rhabdomyosarcoma diagnosed and treated as acute leukemia. (10674913)
2000
33
Metastatic alveolar rhabdomyosarcoma with increased serum creatine kinase MB and cardiac troponin T and normal cardiac troponin I. (10790783)
2000
34
Membrane-bound paracrystalloid structures in alveolar rhabdomyosarcoma. (11247391)
2000
35
Structural analysis of PAX7 rearrangements in alveolar rhabdomyosarcoma. (10700864)
2000
36
Alveolar rhabdomyosarcoma metastatic to the breast: long-term survivor. (10663335)
1999
37
Massive disseminated intravascular coagulation and hyperfibrinolysis in alveolar rhabdomyosarcoma: case report and review of the literature. (10466447)
1999
38
"Juvenile alveolar rhabdomyosarcoma of mandible". (23119581)
1999
39
Solid alveolar rhabdomyosarcoma of the thorax in a child. (9543674)
1998
40
Multiorgan uptake of Tc-99m MDP in a patient with stage 4 alveolar rhabdomyosarcoma. (9619331)
1998
41
Long-lasting complete remission after prolonged administration of etoposide in a child with a second recurrence of alveolar rhabdomyosarcoma. (8986152)
1997
42
Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells. (9405676)
1997
43
The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator. (7630639)
1995
44
Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma. (8634710)
1995
45
Metabolism of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 by blood derived macrophages from a patient with alveolar rhabdomyosarcoma during short-term culture and 1 alpha,25-dihydroxyvitamin D3 after long-term culture. (2009222)
1991
46
Alveolar rhabdomyosarcoma--a case report. (3223793)
1988
47
Congenital alveolar rhabdomyosarcoma with multiple skin metastases. Report of a case. (3389151)
1988
48
Alveolar rhabdomyosarcoma of the greater omentum: a case report. (7444668)
1980
49
Alveolar rhabdomyosarcoma. (5040564)
1972
50
Alveolar rhabdomyosarcoma of the eyelid. Diagnosis by electron microscopy. (5032735)
1972

Variations for Alveolar Rhabdomyosarcoma

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Expression for genes affiliated with Alveolar Rhabdomyosarcoma

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Expression patterns in normal tissues for genes affiliated with Alveolar Rhabdomyosarcoma

Search GEO for disease gene expression data for Alveolar Rhabdomyosarcoma.

Pathways for genes affiliated with Alveolar Rhabdomyosarcoma

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Pathways related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PAX3, PAX7
29.7PAX3, PAX7
3
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
9.1NOV, HES6

Compounds for genes affiliated with Alveolar Rhabdomyosarcoma

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GO Terms for genes affiliated with Alveolar Rhabdomyosarcoma

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Cellular components related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.0FGFR4, HES6, PAX3, PAX7, PMAIP1

Biological processes related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:0486639.7PAX3, PAX7
2spinal cord association neuron differentiationGO:0215279.4PAX3, PAX7

Molecular functions related to Alveolar Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:0037009.2HES6, PAX3, PAX7

Products for genes affiliated with Alveolar Rhabdomyosarcoma

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Sources for Alveolar Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
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