ASPS
MCID: ALV005
MIFTS: 59

Alveolar Soft Part Sarcoma (ASPS) malady

Cancer diseases category

Summaries for Alveolar Soft Part Sarcoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults.

MalaCards: Alveolar Soft Part Sarcoma, also known as alveolar soft-part sarcoma, is related to sarcoma and osteosarcoma. An important gene associated with Alveolar Soft Part Sarcoma is ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), and among its related pathways are CDO in myogenesis and Regulation of nuclear SMAD2/3 signaling. The compounds creatinine and s 100 have been mentioned in the context of this disorder. Affiliated tissues include tongue, cervix and breast, and related mouse phenotypes are muscle and adipose tissue.

Wikipedia:63 Alveolar soft part sarcoma, abbreviated ASPS, is a very rare type of soft tissue sarcoma, that grows... more...

Description from OMIM:46 606243

Aliases & Classifications for Alveolar Soft Part Sarcoma

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
alveolar soft-part sarcoma:
Age of onset: Variable


Aliases & Descriptions:

alveolar soft part sarcoma 8 42 10 60
alveolar soft-part sarcoma 9 46 48
pediatric alveolar soft part sarcoma 8
childhood alveolar soft part sarcoma 8
childhood alveolar soft-part sarcoma 60
adult alveolar soft part sarcoma 8
adult alveolar soft-part sarcoma 60
sarcoma alveolar soft part 44
asps 42


External Ids:

Disease Ontology8 DOID:4239
MeSH34 D018234
NCIt39 C3750
OMIM46 606243
MESH via Orphanet35 D018234
SNOMED-CT via Orphanet57 404056007, 88195001
UMLS via Orphanet61 C0206657

Related Diseases for Alveolar Soft Part Sarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Alveolar Soft Part Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.3ENO2, S100A1, CTAG1B, TFE3, MET, DES
2osteosarcoma30.4MET, MYOD1
3granular cell tumor30.4S100A1, DES, ENO2
4alveolar rhabdomyosarcoma30.4DES, MYOD1, MYOG, ENO2
5chondrosarcoma30.4S100A1, MET, DES, ENO2
6adenoma30.4ENO2, MYOD1, MET, S100A1
7rhabdomyosarcoma30.4S100A1, MET, DES, MYOD1, MYF6, MYOG
8breast cancer30.4S100A1, CTAG1B, MET, ECM1, ADAM9
9lung cancer30.3S100A1, CTAG1B, MET, CYGB, ENO2
10neuroblastoma30.0ENO2
11melanoma30.0S100A1, CTAG1B, MET, DES, MYOD1, SLC16A1
12breast sarcoma10.7
13vagina sarcoma10.7
14cervical alveolar soft part sarcoma10.6
15brain sarcoma10.6
16lung sarcoma10.6
17cerebritis10.6
18vulvar alveolar soft part sarcoma10.6
19renal cell carcinoma10.6
20paraganglioma10.5
21larynx sarcoma10.5
22thalassemia10.5
23urethritis10.4
24bladder sarcoma10.4
25liver sarcoma10.4
26meninges sarcoma10.4
27meningitis10.4
28uterine corpus sarcoma10.4
29alpha thalassemia10.4
30aspergillosis10.4
31beta thalassemia10.3
32allergic bronchopulmonary aspergillosis10.3
33male breast cancer10.3
34myositis ossificans10.3
35clear cell sarcoma10.3
36myeloid sarcoma10.3
37duodenitis10.3
38clear cell chondrosarcoma10.3
39cervicitis10.3
40eosinophilia10.3
41hemangioma10.3
42liver disease10.3
43mediastinum sarcoma10.3
44meningioma10.3
45myositis10.3
46pancreatitis10.3
47pituitary adenoma10.3
48respiratory failure10.3
49retroperitoneal sarcoma10.3
50skin sarcoma10.3

Graphical network of the top 20 diseases related to Alveolar Soft Part Sarcoma:



Diseases related to alveolar soft part sarcoma

Clinical Features for Alveolar Soft Part Sarcoma

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Sources:
46OMIM
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Clinical features from OMIM:

606243

Drugs & Therapeutics for Alveolar Soft Part Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alveolar Soft Part Sarcoma

Drug clinical trials:

Search ClinicalTrials for Alveolar Soft Part Sarcoma

Search NIH Clinical Center for Alveolar Soft Part Sarcoma

Search CenterWatch for Alveolar Soft Part Sarcoma

Genetic Tests for Alveolar Soft Part Sarcoma

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Anatomical Context for Alveolar Soft Part Sarcoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Alveolar Soft Part Sarcoma:

32
Tongue, Cervix, Breast, Bone, Skeletal muscle, Brain, Lung, Uterus, Lymph node, Liver, Pituitary, Myeloid, Endothelial, Skin

Animal Models for Alveolar Soft Part Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alveolar Soft Part Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0MYF6, MYOD1, TRIM63, MET
2MP:00053759.7ANGPTL2, TRIM63, MYOD1, MYF6, MYOG
3MP:00028739.6ADAM9, S100A1, TFE3, MET, MYOD1, MYF6
4MP:00053889.4MET, TRIM63, MYOD1, MYF6, MYOG, ENO2
5MP:00107689.4MET, DES, TRIM63, ECM1, MYOD1, MYF6

Publications for Alveolar Soft Part Sarcoma

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Sources:
50PubMed
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Articles related to Alveolar Soft Part Sarcoma:

(show top 50)    (show all 384)
idTitleAuthorsYear
1
Lung metastasis of primary alveolar soft-part sarcoma occurring 20 years after initial treatment. (24379977)
2013
2
Structured myeloid cells and anti-angiogenic therapy in alveolar soft part sarcoma. (24074204)
2013
3
Cediranib for metastatic alveolar soft part sarcoma. (23630200)
2013
4
Necrosis of a skin autograft after short-term treatment with sunitinib in a 14-year-old girl with metastatic alveolar soft part sarcoma of the thigh. (20514624)
2010
5
Orbital alveolar soft part sarcoma: Histopathologic report of two cases. (23960876)
2010
6
Gene expression profiling of alveolar soft-part sarcoma (ASPS). (19146682)
2009
7
Alveolar soft part sarcoma of the cervix: case report and literature review. (18548261)
2009
8
Therapeutic vulnerability of an in vivo model of alveolar soft part sarcoma (ASPS) to antiangiogenic therapy. (19636271)
2009
9
Acute respiratory failure in a 16-yr-old girl with alveolar soft part sarcoma]. (19469095)
2008
10
Primary cardiac alveolar soft part sarcoma. A report of the first observed case with molecular diagnostics corroboration. (17378669)
2008
11
Alveolar soft part sarcoma of the uterine cervix. (17961160)
2008
12
Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report. (18702365)
2008
13
Metastases to the breast: alveolar soft part sarcoma in adolescents. (18501064)
2008
14
Alveolar soft part sarcoma of the forearm: a case report. (17313933)
2006
15
Alveolar soft part sarcoma: report of a case occurring in the sinonasal region. (15364506)
2004
16
Colic metastases of alveolar soft-part sarcoma: a case report and review of the literature. (14571434)
2003
17
Alveolar soft-part sarcoma of the tongue. (12812945)
2003
18
Periorbital alveolar soft part sarcoma with radiologic features mimicking haemangioma. (12825221)
2003
19
Alveolar soft-part sarcoma of the neck. (12389139)
2002
20
The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. (11244503)
2001
21
Alveolar soft-part sarcoma: a rare soft-tissue malignancy with distinctive clinical and radiological features. (11297086)
2001
22
RT-PCR suggests human skeletal muscle origin of alveolar soft-part sarcoma. (10838498)
2000
23
Primary alveolar soft part sarcoma of bone. (10583555)
1999
24
Giemsa staining for alveolar soft part sarcoma. (10349397)
1999
25
DNA copy number changes in alveolar soft part sarcoma: a comparative genomic hybridization study. (9521467)
1998
26
Breast mass due to alveolar soft part sarcoma of the pectoris major muscle. (9056151)
1997
27
An important role for chromosome 17, band q25, in the histogenesis of alveolar soft part sarcoma. (7627936)
1995
28
Crystal-deficient alveolar soft part sarcoma. (8266593)
1993
29
Alveolar soft-part sarcoma of the hand. (8294733)
1993
30
Case report 796. Alveolar soft part sarcoma. (8372371)
1993
31
Molecular genetic, cytogenetic, and immunohistochemical characterization of alveolar soft-part sarcoma. Implications for cell of origin. (1423174)
1992
32
Multiple and complex abnormalities in a case of alveolar soft-part sarcoma. (1933819)
1991
33
MyoD1 protein expression in alveolar soft part sarcoma as confirmatory evidence of its skeletal muscle nature. (1656801)
1991
34
Alveolar soft part sarcoma of the vagina. (2321279)
1990
35
Alveolar soft-part sarcoma: a hormone-sensitive tumour? (3200782)
1988
36
Alveolar soft part sarcoma of the pituitary gland with secondary involvement of the right cerebral ventricle. (3268152)
1988
37
Fine needle aspiration cytology of alveolar soft-part sarcoma. A case report. (6587695)
1984
38
An ultrastructural and histochemical study of alveolar soft part sarcoma with special reference to the nature of crystals. (6331064)
1984
39
Alveolar soft-part sarcoma. (7137281)
1982
40
Alveolar soft-part sarcoma--A malignant angioreninoma: Histochemical, immunocytochemical, and electron-microscopic study of four cases. (7044159)
1982
41
Touch imprints: their use in the frozen-section diagnosis of alveolar soft-part sarcoma. (7013730)
1981
42
Alveolar soft-part sarcoma of the orbit. (7322485)
1981
43
Alveolar soft part sarcoma of the orbit. (500173)
1979
44
Pulmonary metastases 15 years after removal of an alveolar soft-part sarcoma of the tongue. (547360)
1979
45
Alveolar soft part sarcoma. (633188)
1978
46
Alveolar soft part sarcoma. (651368)
1978
47
Histogenesis of alveolar soft part sarcoma. (4332314)
1972
48
Alveolar soft-part sarcoma. A case report. (5034949)
1972
49
Malignant nonchromaffin paraganglioma or alveolar soft-part sarcoma in the temporal region. (6074147)
1967
50
Alveolar soft-part sarcoma. A case report. (5827444)
1964

Genetic Variations for Alveolar Soft Part Sarcoma

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Expression for genes affiliated with Alveolar Soft Part Sarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alveolar Soft Part Sarcoma

Search GEO for disease gene expression data for Alveolar Soft Part Sarcoma.

Pathways for genes affiliated with Alveolar Soft Part Sarcoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Alveolar Soft Part Sarcoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Alveolar Soft Part Sarcoma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1creatinine4410.5MYF6, MYOD1
2s 1004410.5ENO2, DES
3estrogen4410.4MYOG, MYOD1
4toluidine4410.4ENO2, DES, S100A1
5hematoxylin4410.3S100A1, DES, ENO2
6silver4410.2ENO2, DES, S100A1
7bromodeoxyuridine4410.2DES, MYOD1, MYOG, ENO2
8mucicarmine4410.2S100A1, DES
9biotin44 11 2412.2SLC16A1, DES, S100A1
1012-o-tetradecanoylphorbol 13-acetate4410.2MET, DES, MYOD1, MYOG
11iron44 2411.1S100A1, DES, TRIM63, CYGB, ENO2
12acetylcholine44 49 28 11 2414.0S100A1, DES, MYOD1, MYF6, MYOG, ENO2
13paraffin4410.0S100A1, MET, DES, MYOD1, MYOG, ENO2
14testosterone44 59 11 2412.9MET, DES, MYOD1, MYOG, ENO2
15glucose449.9TFE3, MET, DES, MYOD1, MYOG, SLC16A1
16oxygen44 2410.9MET, DES, MYOD1, MYOG, CYGB, ENO2
17retinoic acid44 2410.9S100A1, MET, DES, TRIM63, MYOD1, MYOG
18cysteine449.9S100A1, MET, DES, MYOD1, MYOG, CYGB
19glycogen44 2410.9S100A1, MET, DES, ENO2
20nitric oxide44 11 2411.8ENO2, S100A1, MET, DES, TRIM63, MYOG
21tyrosine449.6MET, DES, TRIM63, MYOD1, MYOG, ENO2
22calcium44 49 11 2412.1S100A1, MET, DES, NTSR2, MYOD1, MYOG

GO Terms for genes affiliated with Alveolar Soft Part Sarcoma

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16Gene Ontology
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Biological processes related to Alveolar Soft Part Sarcoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to electrical stimulus involved in regulation of muscle adaptationGO:01487810.3MYOG, TRIM63
2muscle cell fate commitmentGO:04269310.2MYOG, MYF6, MYOD1
3cellular response to estradiol stimulusGO:07139210.2MYOG, MYOD1
4positive regulation of muscle cell differentiationGO:05114910.2TCF3, MYOG, MYF6, MYOD1
5muscle cell differentiationGO:04269210.1MYOD1, MYF6, MYOG, TCF3
6skeletal muscle tissue developmentGO:00751910.1MYOD1, MYF6, MYOG
7skeletal muscle fiber developmentGO:0487419.9MYOG, MYOD1
8positive regulation of transcription from RNA polymerase II promoterGO:0459449.7TFE3, MET, MYOD1, MYF6, MYOG, TCF3

Molecular functions related to Alveolar Soft Part Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.0TCF3, MYOG, MYF6, MYOD1
2laminin bindingGO:04323610.0ECM1, ADAM9
3E-box bindingGO:0708889.9TCF3, MYOG, MYF6, MYOD1

Products for genes affiliated with Alveolar Soft Part Sarcoma

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  • Antibodies
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Sources for Alveolar Soft Part Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet