ASPS
MCID: ALV005
MIFTS: 56

Alveolar Soft Part Sarcoma (ASPS) malady

Cancer category

Summaries for Alveolar Soft Part Sarcoma

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults.

MalaCards: Alveolar Soft Part Sarcoma, also known as alveolar soft-part sarcoma, is related to granular cell tumor and alveolar rhabdomyosarcoma. An important gene associated with Alveolar Soft Part Sarcoma is ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), and among its related pathways are CDO in myogenesis and Regulation of nuclear SMAD2/3 signaling. The compounds creatinine and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and smooth muscle, and related mouse phenotypes are muscle and adipose tissue.

Wikipedia:64 Alveolar soft part sarcoma, abbreviated ASPS, is a very rare type of soft tissue sarcoma, that grows... more...

Description from OMIM:47 606243

Aliases & Classifications for Alveolar Soft Part Sarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 9diseasecard, 47OMIM, 49Orphanet, 45Novoseek, 35MeSH, 40NCIt, 57SNOMED-CT, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
alveolar soft-part sarcoma:
Age of onset: Variable


Aliases & Descriptions:

alveolar soft part sarcoma 8 43 10 61
alveolar soft-part sarcoma 9 47 49
pediatric alveolar soft part sarcoma 8
childhood alveolar soft part sarcoma 8
childhood alveolar soft-part sarcoma 61
adult alveolar soft part sarcoma 8
adult alveolar soft-part sarcoma 61
sarcoma alveolar soft part 45
asps 43


External Ids:

Disease Ontology8 DOID:4239
MeSH35 D018234
NCIt40 C3750
OMIM47 606243
MESH via Orphanet36 D018234
SNOMED-CT via Orphanet58 404056007, 88195001
UMLS via Orphanet62 C0206657

Related Diseases for Alveolar Soft Part Sarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alveolar Soft Part Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1granular cell tumor30.4DES, S100A1, ENO2
2alveolar rhabdomyosarcoma30.4ENO2, MYOG, DES, MYOD1
3adenoma30.4ENO2, MYOD1, MET, S100A1
4soft tissue sarcoma10.8
5uterine sarcoma10.8
6vagina sarcoma10.7
7cervical alveolar soft part sarcoma10.6
8brain sarcoma10.6
9vulvar alveolar soft part sarcoma10.6
10cerebral sarcoma10.6
11thalassemia10.5
12paranasal sinus sarcoma10.5
13paraganglioma10.5
14alpha thalassemia10.5
15beta thalassemia10.5
16bladder sarcoma10.4
17uterine corpus sarcoma10.4
18aspergillosis10.4
19allergic bronchopulmonary aspergillosis10.3
20male breast cancer10.3
21myositis ossificans10.3
22clear cell sarcoma10.3
23myeloid sarcoma10.3
24clear cell chondrosarcoma10.3
25skin sarcoma10.3
26coronary artery disease,10.3
27canavan disease10.1
28hypophosphatasia10.1
29delta-beta thalassemia10.1
30thalassemia, delta-10.1
31hemoglobin c - beta-thalassemia10.1
32stroke, ischemic10.0
33t-cell leukemia10.0
34angel shaped phalangoepiphyseal dysplasia10.0
35hemoglobin so10.0
36insulin resistance10.0
37hyperapobetalipoproteinemia10.0
38perivascular epithelioid cell tumor10.0TFE3
39rhabdoid tumor10.0MYOD1, DES
40neuroblastoma10.0ENO2
41malignant mesenchymoma10.0MYOG, MYOD1
42seminoma10.0ENO2
43angiomyolipoma10.0DES, S100A1
44hemangioblastoma10.0ENO2
45dermatofibrosarcoma protuberans10.0DES, S100A1
46epulis10.0ENO2
47pseudosarcomatous fibromatosis10.0MYOG, DES
48rhabdoid cancer10.0ENO2
49myopathy10.0DES, MYOD1, MYOG
50embryonal rhabdomyosarcoma10.0DES, MYOD1, MYOG

Graphical network of the top 20 diseases related to Alveolar Soft Part Sarcoma:



Diseases related to alveolar soft part sarcoma

Clinical Features for Alveolar Soft Part Sarcoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

606243

Drugs & Therapeutics for Alveolar Soft Part Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alveolar Soft Part Sarcoma

Drug clinical trials:

Search ClinicalTrials for Alveolar Soft Part Sarcoma

Search NIH Clinical Center for Alveolar Soft Part Sarcoma

Search CenterWatch for Alveolar Soft Part Sarcoma

Genetic Tests for Alveolar Soft Part Sarcoma

Anatomical Context for Alveolar Soft Part Sarcoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Alveolar Soft Part Sarcoma:

33
Lymph node, Brain, Smooth muscle, Skeletal muscle, Liver, Lung, Breast, Skin, Uterus, Cervix, Myeloid, T cells, Endothelial, Temporal lobe, Tongue, Pituitary, Uterus corpus

Animal Models for Alveolar Soft Part Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Alveolar Soft Part Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0MYF6, MYOD1, TRIM63, MET
2MP:00053759.7ANGPTL2, TRIM63, MYOD1, MYF6, MYOG
3MP:00028739.6ADAM9, S100A1, TFE3, MET, MYOD1, MYF6
4MP:00053889.4MET, TRIM63, MYOD1, MYF6, MYOG, ENO2
5MP:00107689.4MET, DES, TRIM63, ECM1, MYOD1, MYF6

Publications for Alveolar Soft Part Sarcoma

Sources:
51PubMed
See all sources

Articles related to Alveolar Soft Part Sarcoma:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
Alveolar soft-part sarcoma in the sacrum: a case report and review of the literature. (24092236)
2014
2
Alveolar soft part sarcoma-radiologic patterns in children and adolescents. (23681452)
2013
3
Paediatric and adolescent alveolar soft part sarcoma: A joint series from European cooperative groups. (23857870)
2013
4
Alveolar soft part sarcoma: a single-center 26-patient case series and review of the literature. (22666000)
2012
5
Alveolar soft part sarcoma: should we be targeting the tumor or targeting the vasculature? (22868501)
2012
6
Alveolar soft-part sarcoma of tongue. (21934227)
2011
7
Alveolar soft part sarcoma occurring on the abdominal wall of a 2-year-old child. (21317811)
2011
8
Alveolar soft part sarcoma of the retro peritoneum. (20479565)
2010
9
Persistent alveolar soft-part sarcoma with liver metastasis: a case report. (20673324)
2010
10
Dual-color, break-apart FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of Xp11 translocation renal cell carcinoma and alveolar soft part sarcoma. (20421778)
2010
11
Bone scintigraphic images of a patient with unusual metastatic alveolar soft-part sarcoma. (19851182)
2009
12
Alveolar soft part sarcoma of the tongue. (19884839)
2009
13
Ultrasonographic and MR findings of alveolar soft part sarcoma. (19541571)
2009
14
Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors. (17614855)
2007
15
Alveolar soft part sarcoma. (17516754)
2007
16
Alveolar soft-part sarcoma of the retroperitoneum. (17010020)
2006
17
Alveolar soft-part sarcoma: a cardiac metastasis as a rare site of relapse. (16891875)
2006
18
Metastatic alveolar soft part sarcoma of the breast. (16798907)
2006
19
Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults. (16410131)
2006
20
Interferon alpha for alveolar soft part sarcoma. (15602705)
2005
21
Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy. (15735860)
2005
22
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: alveolar soft part sarcoma. (12165444)
2002
23
APC and beta-catenin in alveolar soft part sarcoma (ASPS)--immunohistochemical and molecular genetic analysis. (10834386)
2000
24
Alveolar soft-part sarcoma of the cheek: report of a case with a review of the literature. (11071241)
2000
25
Pulmonary metastases of alveolar soft-part sarcoma: CT findings in three patients. (11752930)
2000
26
Alveolar soft part sarcoma: a review and update. (10342010)
1999
27
Alveolar soft part sarcoma. (9601970)
1998
28
Trisomy 8 in alveolar soft part sarcoma. (7773967)
1995
29
Successful treatment for solitary brain metastasis from alveolar soft part sarcoma. (8543972)
1995
30
Alveolar soft-part sarcoma of the oral cavity: report of a case and review of the literature. (7562177)
1995
31
Subcutaneous alveolar soft-part sarcoma mimicking metastatic hypernephroma. (8117564)
1993
32
Tc-99m HMDP accumulation in an alveolar soft part sarcoma. (8344039)
1993
33
Pathological case of the month. Alveolar soft-part sarcoma. (1496954)
1992
34
The histogenesis of alveolar soft part sarcoma: a clinicopathological analysis of 135 cases]. (2279303)
1990
35
Alveolar soft part sarcoma. Immunohistochemical evidence for muscle cell differentiation. (2403741)
1990
36
Alveolar soft part sarcoma of the cervix uteri. A case report. (2748460)
1989
37
Alveolar soft-part sarcoma. A clinico-pathologic study of half a century. (2642727)
1989
38
Alveolar soft part sarcoma: immunological evidence of rhabdomyoblastic differentiation. (3209185)
1988
39
Alveolar soft part sarcoma. An immunohistochemical, cytologic and electron-microscopic study and a quantitative DNA analysis. (3129865)
1988
40
Alveolar soft part sarcoma of the nasal cavity. (2853325)
1988
41
Alveolar soft-part sarcoma. (3377402)
1988
42
Alveolar soft-part sarcoma of the orbit (a case report). (3443501)
1986
43
Alveolar soft-part sarcoma. A study of 13 typical examples and one with a histologically atypical component. (3967185)
1985
44
Sarcomas--a clinicopathological guide with special reference to cutaneous manifestation. IV. Extraskeletal osteosarcoma, extraskeletal chondrosarcoma, alveolar soft part sarcoma, clear cell sarcoma and discussion. (3912082)
1985
45
Alveolar soft part sarcoma in the vagina: clinical features and morphology. (7372195)
1980
46
The ultrasonographic and radiologic features of a histologically proven case of alveolar soft-part sarcoma of the orbit. (453307)
1979
47
Alveolar soft-part sarcoma in the oral cavity: report of a case. (1059755)
1976
48
Alveolar soft-part sarcoma. Report of a case presenting as asymptomatic pulmonary nodules. (4635435)
1972
49
Alveolar soft-part sarcoma. (5770452)
1969
50
Alveolar soft-part sarcoma of the orbit. (5635346)
1968

Genetic Variations for Alveolar Soft Part Sarcoma

Expression for genes affiliated with Alveolar Soft Part Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alveolar Soft Part Sarcoma

Search GEO for disease gene expression data for Alveolar Soft Part Sarcoma.

Pathways for genes affiliated with Alveolar Soft Part Sarcoma

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Alveolar Soft Part Sarcoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Alveolar Soft Part Sarcoma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1creatinine4510.5MYF6, MYOD1
2s 1004510.5ENO2, DES
3estrogen4510.4MYOG, MYOD1
4toluidine4510.4ENO2, DES, S100A1
5hematoxylin4510.3S100A1, DES, ENO2
6silver4510.2ENO2, DES, S100A1
7bromodeoxyuridine4510.2DES, MYOD1, MYOG, ENO2
8mucicarmine4510.2S100A1, DES
9biotin45 11 2412.2SLC16A1, DES, S100A1
1012-o-tetradecanoylphorbol 13-acetate4510.2MET, DES, MYOD1, MYOG
11iron45 2411.1S100A1, DES, TRIM63, CYGB, ENO2
12acetylcholine45 50 29 11 2414.0S100A1, DES, MYOD1, MYF6, MYOG, ENO2
13paraffin4510.0S100A1, MET, DES, MYOD1, MYOG, ENO2
14testosterone45 60 11 2412.9MET, DES, MYOD1, MYOG, ENO2
15glucose459.9TFE3, MET, DES, MYOD1, MYOG, SLC16A1
16oxygen45 2410.9MET, DES, MYOD1, MYOG, CYGB, ENO2
17retinoic acid45 2410.9S100A1, MET, DES, TRIM63, MYOD1, MYOG
18cysteine459.9S100A1, MET, DES, MYOD1, MYOG, CYGB
19glycogen45 2410.9S100A1, MET, DES, ENO2
20nitric oxide45 11 2411.8ENO2, S100A1, MET, DES, TRIM63, MYOG
21tyrosine459.6MET, DES, TRIM63, MYOD1, MYOG, ENO2
22calcium45 50 11 2412.1S100A1, MET, DES, NTSR2, MYOD1, MYOG

GO Terms for genes affiliated with Alveolar Soft Part Sarcoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Alveolar Soft Part Sarcoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to electrical stimulus involved in regulation of muscle adaptationGO:01487810.3MYOG, TRIM63
2muscle cell fate commitmentGO:04269310.2MYOG, MYF6, MYOD1
3cellular response to estradiol stimulusGO:07139210.2MYOG, MYOD1
4positive regulation of muscle cell differentiationGO:05114910.2TCF3, MYOG, MYF6, MYOD1
5muscle cell differentiationGO:04269210.1MYOD1, MYF6, MYOG, TCF3
6skeletal muscle tissue developmentGO:00751910.1MYOD1, MYF6, MYOG
7skeletal muscle fiber developmentGO:0487419.9MYOG, MYOD1
8positive regulation of transcription from RNA polymerase II promoterGO:0459449.7TFE3, MET, MYOD1, MYF6, MYOG, TCF3

Molecular functions related to Alveolar Soft Part Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.0TCF3, MYOG, MYF6, MYOD1
2laminin bindingGO:04323610.0ECM1, ADAM9
3E-box bindingGO:0708889.9TCF3, MYOG, MYF6, MYOD1

Products for genes affiliated with Alveolar Soft Part Sarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alveolar Soft Part Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet