MCID: ALV010
MIFTS: 57

Alveolar Soft-Part Sarcoma malady

Genetic diseases, Rare diseases, Cancer diseases categories

Aliases & Classifications for Alveolar Soft-Part Sarcoma

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Sources:
45OMIM, 10diseasecard, 41NIH Rare Diseases, 47Orphanet, 9Disease Ontology, 11DISEASES, 60UMLS, 43Novoseek, 38NCIt, 55SNOMED-CT, 33MeSH, 34MESH via Orphanet, 61UMLS via Orphanet
See all sources

Alveolar Soft-Part Sarcoma, Aliases & Descriptions:

Name: Alveolar Soft-Part Sarcoma 45 10 41 47
Alveolar Soft Part Sarcoma 45 9 41 11 60
Alveolar Soft-Tissue Sarcoma 41 47
Asps 41 47
Pediatric Alveolar Soft Part Sarcoma 9
 
Childhood Alveolar Soft Part Sarcoma 9
Childhood Alveolar Soft-Part Sarcoma 60
Adult Alveolar Soft Part Sarcoma 9
Adult Alveolar Soft-Part Sarcoma 60
Sarcoma Alveolar Soft Part 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
alveolar soft-part sarcoma:
Age of onset: All ages


External Ids:

OMIM45 606243
Disease Ontology9 DOID:4239
NCIt38 C3750
MeSH33 D018234
Orphanet47 163699
MESH via Orphanet34 D018234
UMLS via Orphanet61 C0206657

Summaries for Alveolar Soft-Part Sarcoma

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OMIM:45 Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructure,... (606243) more...

MalaCards based summary: Alveolar Soft-Part Sarcoma, also known as alveolar soft part sarcoma, is related to sarcoma and renal cell carcinoma, and has symptoms including somatic mutationand alveolar soft part sarcoma. An important gene associated with Alveolar Soft-Part Sarcoma is ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), and among its related pathways are Transcriptional misregulation in cancer and Alpha6-Beta4 Integrin Signaling Pathway. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include tongue, cervix and breast, and related mouse phenotypes are vision/eye and craniofacial.

Disease Ontology:9 A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults.

Wikipedia:63 Alveolar soft part sarcoma, abbreviated ASPS, is a very rare type of soft tissue sarcoma, that grows... more...

Related Diseases for Alveolar Soft-Part Sarcoma

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Diseases related to Alveolar Soft-Part Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.2DES, TFE3, VIM, MYOD1, MET, ENO2
2renal cell carcinoma31.6MET, TFE3
3granular cell tumor31.0DES, VIM, ENO2
4adenoma30.2IGFBP1, MYOD1, PRL, MET, ENO2
5rhabdomyosarcoma29.8DES, SMAD3, VIM, MYF6, MYOD1, MET
6breast cancer29.5IGFBP1, ECM1, SMAD3, HIF1A, PRL, MET
7vulvar alveolar soft part sarcoma10.7
8cervical alveolar soft part sarcoma10.7
9cerebritis10.6
10sinusitis10.6
11paraganglioma10.6
12meningitis10.6
13soft tissue sarcoma10.6
14perivascular epithelioid cell tumor10.6TFE3
15infantile myofibromatosis10.6DES
16epulis10.5ENO2
17subependymal giant cell astrocytoma10.5ENO2
18myopathy, centronuclear10.5DES
19neurilemmoma10.5ENO2
20urethritis10.5
21ewing's family of tumors10.5ENO2
22peripheral primitive neuroectodermal tumor10.4ENO2
23adenomatoid tumor10.4VIM
24embryonal rhabdomyosarcoma10.4DES, MYOD1
25chordoma10.4VIM, DES
26epithelioid leiomyosarcoma10.4VIM, DES
27mesenchymal chondrosarcoma10.4DES, VIM
28pseudosarcomatous fibromatosis10.4DES, VIM
29spindle cell carcinoma10.3DES, VIM
30spindle cell sarcoma10.3VIM, DES
31dermatofibrosarcoma protuberans10.3DES, VIM
32fibrous histiocytoma10.3DES, VIM
33endometrial stromal sarcoma10.3DES, VIM
34hemangiopericytoma10.3VIM, DES
35hemangioma10.3
36vulvovaginitis10.3
37myositis ossificans10.3
38clear cell sarcoma10.3
39duodenitis10.3
40cervicitis10.3
41eosinophilia10.3
42mediastinitis10.3
43myositis10.3
44pancreatitis10.3
45pituitary adenoma10.3
46prostatitis10.3
47respiratory failure10.3
48retroperitoneal sarcoma10.3
49vaginitis10.3
50endotheliitis10.3

Graphical network of the top 20 diseases related to Alveolar Soft-Part Sarcoma:



Diseases related to alveolar soft-part sarcoma

Symptoms for Alveolar Soft-Part Sarcoma

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Clinical features from OMIM:

606243

HPO human phenotypes related to Alveolar Soft-Part Sarcoma:

id Description Frequency HPO Source Accession
1 somatic mutation HP:0001428
2 alveolar soft part sarcoma HP:0012218

Drugs & Therapeutics for Alveolar Soft-Part Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Alveolar Soft-Part Sarcoma

Search NIH Clinical Center for Alveolar Soft-Part Sarcoma

Genetic Tests for Alveolar Soft-Part Sarcoma

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Anatomical Context for Alveolar Soft-Part Sarcoma

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MalaCards organs/tissues related to Alveolar Soft-Part Sarcoma:

31
Tongue, Cervix, Breast, Bone, Brain, Skeletal muscle, Lung, Uterus, Lymph node, Liver, Pituitary, Kidney, Skin, Prostate, Myeloid, Endothelial

Animal Models for Alveolar Soft-Part Sarcoma or affiliated genes

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Publications for Alveolar Soft-Part Sarcoma

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Articles related to Alveolar Soft-Part Sarcoma:

(show top 50)    (show all 402)
idTitleAuthorsYear
1
Imaging features of alveolar soft-part sarcoma: a report from Children's Oncology Group Study ARST0332. (25415714)
2014
2
Alveolar soft part sarcoma arising from the kidney: imaging and clinical features. (24843244)
2014
3
Management of recurrent alveolar soft-part sarcoma of the tongue after external beam radiotherapy with iodine-125 seed brachytherapy. (24585519)
2014
4
Imaging Findings and Histologic Appearances of Alveolar Soft Part Sarcoma in the Prostate: A Case Report and Review of the Literature. (25604914)
2014
5
Molecular cytogenetic analysis for TFE3 rearrangement in Xp11.2 renal cell carcinoma and alveolar soft part sarcoma: validation and clinical experience with 75 cases. (23828314)
2014
6
Lung metastasis of primary alveolar soft-part sarcoma occurring 20 years after initial treatment. (24379977)
2013
7
Alveolar soft part sarcoma 'revisited': clinicopathological review of 47 cases from a tertiary cancer referral centre, including immunohistochemical expression of TFE3 in 22 cases and 21 other tumours. (22173238)
2012
8
Alveolar soft part sarcoma of the uterine cervix in a woman presenting with postmenopausal bleeding: a case report and literature review. (21797137)
2011
9
Long term survival in a metastatic alveolar soft part sarcoma at the time of diagnosis: a case with 17 years of follow-up. (21766518)
2011
10
Duodenal metastasis of alveolar soft part sarcoma. (22191294)
2011
11
Necrosis of a skin autograft after short-term treatment with sunitinib in a 14-year-old girl with metastatic alveolar soft part sarcoma of the thigh. (20514624)
2010
12
Successful sequential antiangiogenic therapy for alveolar soft part sarcoma - a case report. (20557847)
2010
13
Pathology quiz case 1: alveolar soft-part sarcoma (ASPS) of the anterior tonsillar pillar. (20479388)
2010
14
Expression of MET in alveolar soft part sarcoma. (19472090)
2010
15
Orbital alveolar soft part sarcoma: Histopathologic report of two cases. (23960876)
2010
16
Bone scintigraphic images of a patient with unusual metastatic alveolar soft-part sarcoma. (19851182)
2009
17
Primary alveolar soft part sarcoma of vertebra: a case report and literature review. (19347336)
2009
18
Acute respiratory failure in a 16-yr-old girl with alveolar soft part sarcoma]. (19469095)
2008
19
Alveolar soft-part sarcoma of the retroperitoneum. (17010020)
2006
20
Vascular-endothelial-growth-factor (VEGF) expression and possible response to angiogenesis inhibitor bevacizumab in metastatic alveolar soft part sarcoma. (16750504)
2006
21
Interferon alpha for alveolar soft part sarcoma. (15602705)
2005
22
Soft tissue sarcomas. Case 2. Orbital alveolar soft part sarcoma in a child. (15143097)
2004
23
Alveolar soft part sarcoma in Japan: multi-institutional study of 57 patients from the Japanese Musculoskeletal Oncology Group. (12837977)
2003
24
Alveolar soft part sarcoma: a unique tumor with disputed histogenesis. (14716125)
2003
25
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: alveolar soft part sarcoma. (12165444)
2002
26
Metastatic alveolar soft-part sarcoma of the intracranial skull base: case report. (17167641)
2002
27
Alveolar soft part sarcoma: are we at the end or just the beginning of our quest? (11943703)
2002
28
Cytogenetic abnormalities of alveolar soft-part sarcomas using interphase fluorescent in situ hybridization: trisomy for chromosome 7 and monosomy for chromosomes 8 and 18 seem to be characteristic of the tumor. (11253120)
2001
29
RT-PCR suggests human skeletal muscle origin of alveolar soft-part sarcoma. (10838498)
2000
30
Alveolar soft part sarcoma of the tongue. Report of a case. (11071242)
2000
31
Alveolar soft part sarcoma of the tongue. (10687905)
1999
32
Alveolar soft-part sarcoma: further evidence by FISH for the involvement of chromosome band 17q25. (9739024)
1998
33
Alveolar soft part sarcoma: review of nine cases including two cases with unusual histology. (9522219)
1998
34
Intracytoplasmic crystals of alveolar soft part sarcoma: demonstration by Riu's stain. (9250326)
1997
35
Trisomy 8 in alveolar soft part sarcoma. (7773967)
1995
36
Crystal-deficient alveolar soft part sarcoma. (8266593)
1993
37
Alveolar soft part sarcoma: a clinicopathologic and immunohistochemical study of 13 cases]. (1452160)
1992
38
Alveolar soft part sarcoma: an analysis of 8 cases. Review of the literature. (1845480)
1991
39
Alveolar soft-part sarcoma of the tongue. Report of a case. (2111358)
1990
40
Alveolar soft part sarcoma of the nasal cavity: report of a case and a review of the literature. (3054374)
1988
41
Alveolar soft part sarcoma: immunological evidence of rhabdomyoblastic differentiation. (3209185)
1988
42
Alveolar soft-part sarcoma: a hormone-sensitive tumour? (3200782)
1988
43
Fine needle aspiration cytology of alveolar soft-part sarcoma. A case report. (3861045)
1985
44
Alveolar soft part sarcoma of the uterine cervix. (4054722)
1985
45
Alveolar soft part sarcoma following radiotherapy for a spinal hemangioma. A case report. (6722724)
1984
46
Alveolar soft-part sarcoma in the oral cavity: report of a case. (1059755)
1976
47
Alveolar soft-part sarcoma. (4524369)
1974
48
Alveolar soft-part sarcoma. Report of a case presenting as a sacral bone tumor. (5762710)
1969
49
Alveolar soft-part sarcoma. (5770452)
1969
50
Malignant nonchromaffin paraganglioma or alveolar soft-part sarcoma in the temporal region. (6074147)
1967

Variations for Alveolar Soft-Part Sarcoma

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Expression for genes affiliated with Alveolar Soft-Part Sarcoma

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Search GEO for disease gene expression data for Alveolar Soft-Part Sarcoma.

Pathways for genes affiliated with Alveolar Soft-Part Sarcoma

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Compounds for genes affiliated with Alveolar Soft-Part Sarcoma

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Compounds related to Alveolar Soft-Part Sarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1orcein439.9VIM, DES
2s 100439.8DES, ENO2, VIM
3toluidine439.8VIM, ENO2, DES
42-deoxyglucose43 1210.5NPY, HIF1A, IGFBP1
5adriamycin439.5MET, VIM, HIF1A, DES
6hematoxylin439.4VIM, DES, ENO2
7progestin439.4VIM, IGFBP1, DES, PRL
8formaldehyde43 2410.3VIM, NPY, ENO2, DES
9proline439.3HIF1A, DES, MET, VIM, TFE3
10matrigel439.2SMAD3, HIF1A, MET, VIM
11octreotide43 59 28 1212.1PRL, NPY, IGFBP1, ENO2
12glycogen43 2410.1ENO2, DES, MET, VIM, IGFBP1
135-hydroxytryptamine439.0NPY, ENO2, VIM, PRL
14acth439.0ENO2, NPY, PRL, IGFBP1
15rapamycin439.0MET, IGFBP1, VIM, HIF1A, SMAD3
16ribonucleic acid439.0MET, PRL, IGFBP1, ENO2
17etoposide43 49 59 1211.9VIM, SMAD3, HIF1A, ENO2
18indomethacin43 28 59 1211.9VIM, IGFBP1, NPY, ENO2
19cycloheximide438.9SMAD3, VIM, HIF1A, IGFBP1, MET
20gnrh438.9PRL, VIM, SMAD3, IGFBP1, NPY
21bromodeoxyuridine438.9VIM, MYOD1, DES, ENO2
22norepinephrine43 24 1210.9ENO2, IGFBP1, DES, NPY, PRL
23heparin43 28 24 1211.8NPY, ENO2, MET, DES, IGFBP1, VIM
24h2o2438.7DES, CYGB, ADAM9, VIM, HIF1A
2512-o-tetradecanoylphorbol 13-acetate438.7VIM, MET, DES, MYOD1
26dihydrotestosterone43 28 24 1211.6HIF1A, PRL, SMAD3, IGFBP1, DES, VIM
27lactate438.6ENO2, DES, IGFBP1, HIF1A, VIM, NPY
28thymidine43 249.6DES, IGFBP1, SMAD3, HIF1A, MET, ENO2
29progesterone43 28 59 24 1212.6ENO2, DES, IGFBP1, MET, PRL, VIM
30iron43 249.6ENO2, VIM, HIF1A, CYGB, DES
31actinomycin d438.4MYOD1, VIM, HIF1A, IGFBP1, DES, MET
32acetylcholine43 49 28 24 1212.4VIM, MYOD1, NPY, DES, ENO2, MYF6
33threonine438.2MET, DES, IGFBP1, SMAD3, HIF1A, MYOD1
34leucine438.2TFE3, IGFBP1, SMAD3, VIM, MYOD1, ENO2
35butyrate438.1SMAD3, HIF1A, VIM, MYOD1
36creatinine438.0MYOD1, MYF6, VIM, DES, ENO2, NPY
37atp43 288.9MYOD1, MET, ENO2, NPY, HIF1A, VIM
38paraffin437.9DES, HIF1A, VIM, MYOD1, MET, ENO2
39serine437.8IGFBP1, HIF1A, VIM, MYOD1, SMAD3, MET
40cysteine437.8IGFBP1, MYOD1, DES, MET, HIF1A, CYGB
41nitric oxide43 24 129.7DES, SMAD3, IGFBP1, NPY, ENO2, MET
42arginine437.5MET, MYOD1, VIM, NPY, HIF1A, IGFBP1
43retinoic acid43 248.5HIF1A, MYOD1, DES, ENO2, MET, VIM
44vegf437.5MET, MYOD1, VIM, HIF1A, SMAD3, ENO2
45tyrosine437.5MET, NPY, HIF1A, MYOD1, SMAD3, ENO2
46oxygen43 248.4ENO2, ADAM9, DES, MET, CYGB, MYOD1
47alanine437.4VIM, MYOD1, ENO2, HIF1A, NPY, SMAD3
48glucose436.7PRL, DES, TFE3, IGFBP1, NPY, ENO2
49testosterone43 59 24 129.6HIF1A, DES, IGFBP1, SMAD3, VIM, MYOD1
50estrogen436.6MET, ENO2, NPY, DES, PRL, MYOD1

GO Terms for genes affiliated with Alveolar Soft-Part Sarcoma

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Cellular components related to Alveolar Soft-Part Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.4IGFBP1, ECM1, ADAM9, ENO2, NPY
2transcription factor complexGO:00056678.4TCF3, MYOD1, HIF1A, SMAD3
3nucleoplasmGO:00056548.3TCF3, MYOD1, MYF6, HIF1A, SMAD3

Biological processes related to Alveolar Soft-Part Sarcoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of transforming growth factor beta2 productionGO:00329099.7HIF1A, SMAD3
2negative regulation of bone mineralizationGO:00305029.5HIF1A, ECM1
3muscle cell fate commitmentGO:00426939.4MYOD1, MYF6
4glucose homeostasisGO:00425939.4HIF1A, ASPSCR1, MET
5histone H4 acetylationGO:00439679.4TCF3, MYOD1
6positive regulation of muscle cell differentiationGO:00511499.3MYF6, MYOD1, TCF3
7muscle cell differentiationGO:00426929.3TCF3, MYOD1, MYF6
8skeletal muscle tissue developmentGO:00075199.2MYF6, MYOD1, MET
9positive regulation of transcription from RNA polymerase II promoterGO:00459447.9MET, TCF3, MYOD1, MYF6, HIF1A, SMAD3

Molecular functions related to Alveolar Soft-Part Sarcoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1laminin bindingGO:00432369.7ADAM9, ECM1
2E-box bindingGO:00708889.4TCF3, MYOD1, MYF6
3transcription regulatory region DNA bindingGO:00442129.3TFE3, SMAD3, HIF1A, TCF3
4nuclear hormone receptor bindingGO:00352579.3MYOD1, HIF1A
5chromatin DNA bindingGO:00314909.2MYOD1, SMAD3
6sequence-specific DNA binding transcription factor activityGO:00037008.9TFE3, SMAD3, HIF1A, MYF6, TCF3
7protein heterodimerization activityGO:00469828.8HIF1A, MYF6, MYOD1, TCF3
8ubiquitin protein ligase bindingGO:00316258.7MYOD1, HIF1A, SMAD3
9transcription factor bindingGO:00081348.7SMAD3, HIF1A, MYOD1, TCF3
10protein bindingGO:00055156.6DES, ECM1, SMAD3, HIF1A, VIM, MYOD1

Products for genes affiliated with Alveolar Soft-Part Sarcoma

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Sources for Alveolar Soft-Part Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet