MCID: ALV010
MIFTS: 52

Alveolar Soft-Part Sarcoma

Categories: Genetic diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Alveolar Soft-Part Sarcoma

MalaCards integrated aliases for Alveolar Soft-Part Sarcoma:

Name: Alveolar Soft-Part Sarcoma 54 56 13
Alveolar Soft Part Sarcoma 12 50 29 14 69
Asps 50 56
Childhood Alveolar Soft Part Sarcoma 12
Pediatric Alveolar Soft Part Sarcoma 12
Childhood Alveolar Soft-Part Sarcoma 69
Adult Alveolar Soft Part Sarcoma 12
Adult Alveolar Soft-Part Sarcoma 69
Alveolar Soft-Tissue Sarcoma 56
Sarcoma, Alveolar Soft Part 42
Sarcoma Alveolar Soft Part 52

Characteristics:

Orphanet epidemiological data:

56
alveolar soft-tissue sarcoma
Age of onset: All ages;

HPO:

32
alveolar soft-part sarcoma:
Inheritance somatic mutation


Classifications:



External Ids:

OMIM 54 606243
Disease Ontology 12 DOID:4239
MeSH 42 D018234
Orphanet 56 ORPHA163699
MESH via Orphanet 43 D018234
UMLS via Orphanet 70 C0206657
ICD10 via Orphanet 34 C49.9

Summaries for Alveolar Soft-Part Sarcoma

NIH Rare Diseases : 50 alveolar soft part sarcoma (asps) is a rare, slow-growing soft tissue sarcoma. although it has been described in a variety of locations, it most commonly develops on the lower extremities in adults and in the head and neck region of children. asps generally presents as a soft, pain-less lump that is often not associated with any additional signs and symptoms. in many cases, the condition is not diagnosed until the affected person develops symptoms of metastasis to other sites such as the lungs, bones, central nervous system and/or liver. the underlying cause of asps is poorly understood. most cases occur sporadically in people with no family history of the condition. asps is generally treated with surgery; radiation therapy and/or chemotherapy may be considered if the tumor returns. last updated: 3/17/2016

MalaCards based summary : Alveolar Soft-Part Sarcoma, also known as alveolar soft part sarcoma, is related to cervical alveolar soft part sarcoma and vulvar alveolar soft part sarcoma, and has symptoms including alveolar soft part sarcoma An important gene associated with Alveolar Soft-Part Sarcoma is ASPSCR1 (ASPSCR1, UBX Domain Containing Tether For SLC2A4), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Transcriptional misregulation in cancer. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotypes are homeostasis/metabolism and mortality/aging

Disease Ontology : 12 A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults.

OMIM : 54
Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructure, controversial histogenesis, and enigmatic clinical behavior (Lieberman et al., 1989; Ordonez, 1999). The typical histology of ASPS shows well-defined nests of cells with abundant pink cytoplasm. The loss of central cohesion produces a pseudoalveolar appearance (Ladanyi et al., 2001). (606243)

Wikipedia : 72 Alveolar soft part sarcoma, abbreviated ASPS, is a very rare type of soft-tissue sarcoma, that grows... more...

Related Diseases for Alveolar Soft-Part Sarcoma

Diseases related to Alveolar Soft-Part Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
id Related Disease Score Top Affiliating Genes
1 cervical alveolar soft part sarcoma 12.5
2 vulvar alveolar soft part sarcoma 12.5
3 sarcoma 11.2
4 gigantism 10.9 DES MB
5 infantile scoliosis 10.9 DES VIM
6 aortic aneurysm 10.8 DES VIM
7 lymphocytic infiltrate of jessner 10.8 DES VIM
8 esophagus leiomyosarcoma 10.8 DES VIM
9 bile duct sarcoma 10.8 MB MYOD1
10 spleen angiosarcoma 10.8 DES VIM
11 skin lipoma 10.8 DES VIM
12 laryngeal neuroendocrine tumor 10.8 DES VIM
13 omphalocele 10.8 DES MYOD1
14 mannose-binding lectin protein deficiency 10.8 DES VIM
15 testis rhabdomyosarcoma 10.8 DES MYOD1
16 neuromuscular junction disease 10.8 DES MB
17 berk-tabatznik syndrome 10.8 DES VIM
18 extraocular retinoblastoma 10.8 DES MB
19 cellular ependymoma 10.8 DES VIM
20 malignant hyperthermia susceptibility type 3 10.8 DES ENO2
21 ovary rhabdomyosarcoma 10.7 DES ENO2
22 immunodeficiency, centromere instability and facial anomalies syndrome 10.7 DES MYOD1
23 benallegue lacete syndrome 10.7 ENO2 VIM
24 cardiac tamponade 10.7 DES MYOD1
25 follicular infundibulum tumor 10.7 DES VIM
26 small intestine neuroendocrine neoplasm 10.7 DES VIM
27 embryonal extrahepatic bile duct rhabdomyosarcoma 10.7 MB MYOD1
28 childhood pleomorphic rhabdomyosarcoma 10.7 DES VIM
29 lung benign neoplasm 10.7 ENO2 MB
30 localized osteosarcoma 10.7 DES MYOD1
31 aggressive systemic mastocytosis 10.7 MET VIM
32 neurogenic thoracic outlet syndrome 10.7 SYP VIM
33 lateral medullary syndrome 10.7 MB MYOD1
34 vulvar squamous papilloma 10.7 DES VIM
35 spindle cell liposarcoma 10.7 DES VIM
36 reticular pattern testicular yolk sac tumor 10.7 SYP VIM
37 duane anomaly mental retardation 10.7 DES MET
38 paranasal sinus cancer 10.7 ENO2 SYP
39 ampulla of vater small cell carcinoma 10.7 ENO2 SYP
40 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.7 ENO2 SYP
41 childhood choriocarcinoma of the ovary 10.7 ENO2 SYP
42 glomus tumor 10.6 ENO2 SYP
43 osteoblastoma 10.6 ENO2 SYP
44 anaplastic oligodendroglioma 10.6 SYP VIM
45 bronchus adenoma 10.6 ENO2 SYP
46 cystitis cystica 10.6 ENO2 SYP
47 small intestine cancer, childhood 10.6 ENO2 SYP
48 pemphigus foliaceus 10.6 ENO2 SYP
49 gallbladder adenocarcinoma 10.6 ENO2 SYP
50 juvenile xanthogranuloma 10.6 DES VIM

Graphical network of the top 20 diseases related to Alveolar Soft-Part Sarcoma:



Diseases related to Alveolar Soft-Part Sarcoma

Symptoms & Phenotypes for Alveolar Soft-Part Sarcoma

Clinical features from OMIM:

606243

Human phenotypes related to Alveolar Soft-Part Sarcoma:

32
id Description HPO Frequency HPO Source Accession
1 alveolar soft part sarcoma 32 HP:0012218

MGI Mouse Phenotypes related to Alveolar Soft-Part Sarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ADAM9 DES ECM1 MB MET MLH1
2 mortality/aging MP:0010768 10.03 ADAM9 DES ECM1 MB MET MLH1
3 neoplasm MP:0002006 9.63 ADAM9 MET MLH1 MYF6 MYOD1 TCF3
4 normal MP:0002873 9.5 ADAM9 MET MYF6 MYOD1 SYP TCF3
5 respiratory system MP:0005388 9.17 MLH1 MYF6 MYOD1 VIM ENO2 MB

Drugs & Therapeutics for Alveolar Soft-Part Sarcoma

Drugs for Alveolar Soft-Part Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
4
Dacarbazine Approved, Investigational Phase 3,Phase 2 4342-03-4 5351166
5
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
6
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
7
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
8
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
9
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
10
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
11
Lenograstim Approved Phase 3,Phase 2 135968-09-1
12
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
13
Cyproheptadine Approved Phase 3 129-03-3 2913
14
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
15
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
16 Alkylating Agents Phase 3,Phase 2,Phase 1
17 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
18 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
19 Isophosphamide mustard Phase 3,Phase 2,Phase 1
20 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
21 Anti-Infective Agents Phase 3,Phase 2
22 Antimitotic Agents Phase 3,Phase 2
23 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
24 Antirheumatic Agents Phase 3,Phase 2
25 Etoposide phosphate Phase 3,Phase 2
26 Immunosuppressive Agents Phase 3,Phase 2
27 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
28 Anti-Allergic Agents Phase 3
29 Antipruritics Phase 3
30 Dermatologic Agents Phase 3
31 Gastrointestinal Agents Phase 3
32 Histamine Antagonists Phase 3
33 Histamine H1 Antagonists Phase 3
34
Histamine Phosphate Phase 3 51-74-1 65513
35 Neurotransmitter Agents Phase 3
36
Serotonin Phase 3 50-67-9 5202
37 Serotonin Agents Phase 3
38 Serotonin Antagonists Phase 3
39
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
40
Everolimus Approved Phase 2 159351-69-6 6442177
41
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
42
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
43
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
44
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
45
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
46
Pembrolizumab Approved Phase 2 1374853-91-4
47
Gemcitabine Approved Phase 2 95058-81-4 60750
48
Crizotinib Approved Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
49
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
50
Cediranib Investigational Phase 2 288383-20-0 9933475

Interventional clinical trials:

(show all 43)

id Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
4 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
5 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
6 A Phase III Trial of Anlotinib in Metastatic or Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma and Synovial Sarcoma Recruiting NCT03016819 Phase 3 AL 3818;Dacarbazine
7 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
8 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
9 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
10 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
11 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
12 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
13 A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas Completed NCT00401388 Phase 2 Perifosine;Perifosine
14 Phase 2 Study in Patients With MiT Tumors Completed NCT00557609 Phase 2 ARQ 197
15 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
16 Treatment of Patients With RAD001 Who Have Progressive Sarcoma Completed NCT00767819 Phase 2 Everolimus/RAD001
17 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
18 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
19 Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
20 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
21 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
22 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
23 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
24 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
25 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
26 Atezolizumab in Treating Patients With Newly Diagnosed and Metastatic Alveolar Soft Part Sarcoma That Cannot Be Removed by Surgery Recruiting NCT03141684 Phase 2 Atezolizumab
27 Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas Recruiting NCT02636725 Phase 2 Axitinib;Pembrolizumab
28 Sunitinib or Cediranib for Alveolar Soft Part Sarcoma Recruiting NCT01391962 Phase 2 Cediranib;Sunitinib
29 Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors Recruiting NCT02867592 Phase 2 Cabozantinib S-malate
30 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
31 Autologous Dendritic Cell Vaccine Loaded With Allogeneic Tumor Lysate Expression of Cancer Testis Antigens in Patients With Soft Tissue Sarcoma Recruiting NCT01883518 Phase 1, Phase 2
32 A Trial of Cediranib in the Treatment of Patients With Alveolar Soft Part Sarcoma (CASPS) Active, not recruiting NCT01337401 Phase 2 Cediranib;Placebo
33 Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part Sarcoma Active, not recruiting NCT00942877 Phase 2 AZD2171
34 CREATE: Cross-tumoral Phase 2 With Crizotinib Active, not recruiting NCT01524926 Phase 2 Crizotinib (PF-02341066)
35 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Active, not recruiting NCT01614795 Phase 2 temsirolimus
36 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2 Dasatinib
37 Pazopanib for Metastatic Alveolar Soft Part Sarcoma Terminated NCT02113826 Phase 2 Pazopanib
38 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
39 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
40 Vaccine Trial for Clear Cell Sarcoma, Pediatric Renal Cell Carcinoma, Alveolar Soft Part Sarcoma and Children With Stage IV Melanoma Active, not recruiting NCT00258687 Phase 1
41 Collection of Alveolar Soft Part Sarcoma and Blood Specimens for Research Completed NCT00340353
42 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
43 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 glutamine

Search NIH Clinical Center for Alveolar Soft-Part Sarcoma

Cochrane evidence based reviews: sarcoma, alveolar soft part

Genetic Tests for Alveolar Soft-Part Sarcoma

Genetic tests related to Alveolar Soft-Part Sarcoma:

id Genetic test Affiliating Genes
1 Alveolar Soft Part Sarcoma 29

Anatomical Context for Alveolar Soft-Part Sarcoma

MalaCards organs/tissues related to Alveolar Soft-Part Sarcoma:

39
Bone, Lung, Liver, Tongue, Cervix, Breast, Brain

Publications for Alveolar Soft-Part Sarcoma

Articles related to Alveolar Soft-Part Sarcoma:

(show top 50) (show all 461)
id Title Authors Year
1
Alveolar soft part sarcoma: A case report with emphasis on some unusual cytological features. ( 28905497 )
2017
2
Alveolar soft-part sarcoma of the mediastinum: A case report. ( 28321306 )
2017
3
Rare Case Report of Alveolar Soft Part Sarcoma of the Orbit. ( 28546729 )
2017
4
Advanced alveolar soft part sarcoma responds to apatinib. ( 28679123 )
2017
5
Alveolar soft part sarcoma metastatic to the mandible: A report and review of literature. ( 28774857 )
2017
6
Magnetic Resonance Features and Characteristic Vascular Pattern of Alveolar Soft-Part Sarcoma. ( 28950275 )
2017
7
Frequent expression of human leukocyte antigen class I and the status of intratumoral immune cells in alveolar soft part sarcoma. ( 28454377 )
2017
8
First reported case of alveolar soft part sarcoma in constitutional mismatch repair deficiency syndrome tumor spectrum - diagnosed in one of the siblings with constitutional mismatch repair deficiency. ( 28413802 )
2017
9
Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor. ( 27696380 )
2017
10
Alveolar soft part sarcoma of orbit: A rare diagnosis. ( 28844593 )
2017
11
The Significant Effects of Pazopanib on Multiple Pulmonary Metastatic Lesions of Alveolar Soft Part Sarcoma: A Case Report. ( 28060129 )
2017
12
Recurrent alveolar soft part sarcoma of the uterine cervix. ( 28599591 )
2017
13
Identification of target genes of cediranib in alveolar soft part sarcoma using a gene microarray. ( 28454442 )
2017
14
Laryngeal alveolar soft part sarcoma: A case report of a rare malignancy in an atypical location. ( 28131550 )
2017
15
Long-term results of therapy with sunitinib in metastatic alveolar soft part sarcoma. ( 28291905 )
2017
16
Metastatic Alveolar Soft Part Sarcoma of the Spinal Cord: A Case Report and Review of Literature. ( 28450230 )
2017
17
An atypical presentation of alveolar soft part sarcoma of tongue. ( 28706396 )
2017
18
Alveolar soft part sarcoma with brain metastases. ( 28413551 )
2017
19
Alveolar Soft Part Sarcoma with Unusual Cardiac Metastasis: A Case Report and Review of the Literature. ( 28845314 )
2017
20
Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma. ( 28945796 )
2017
21
Alveolar soft part sarcoma: the new primary intracranial malignancy : A case report and review of the literature. ( 28744773 )
2017
22
Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma. ( 28754721 )
2017
23
Exploring the Histogenesis and Diagnostic Strategy Using Immunoassay and RT-PCR in Alveolar Soft Part Sarcoma. ( 28766250 )
2017
24
Surgical management and outcome of spinal alveolar soft part sarcoma (ASPA): a case series of five patients and literature review. ( 28166791 )
2017
25
Alveolar soft part sarcoma presenting with back pain. ( 28446481 )
2017
26
Alveolar soft part sarcoma associated with lung and brain metastases: A case report. ( 27446376 )
2016
27
Alveolar Soft Part Sarcoma of Urinary Bladder Occurring as a Second Primary Malignancy: A Case Report and Literature Review. ( 27547480 )
2016
28
Orbital Alveolar Soft Part Sarcoma. ( 27342327 )
2016
29
Primary alveolar soft part sarcoma of the right femur and primary lymphoma of the left femur: A case report and literature review. ( 26870173 )
2016
30
Human Cytomegalovirus is Present in Alveolar Soft Part Sarcoma. ( 26990748 )
2016
31
Magnetic resonance imaging and computed tomography features of alveolar soft-part sarcoma in the right deltoid muscle: A case report. ( 27073564 )
2016
32
A retrospective analysis of 14 consecutive Chinese patients with unresectable or metastatic alveolar soft part sarcoma treated with sunitinib. ( 27604635 )
2016
33
Alveolar Soft Part Sarcoma of the Female Genital Tract: A Morphologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases With Emphasis on its Distinction From Morphologic Mimics. ( 28009610 )
2016
34
Perineal alveolar soft part sarcoma treated by laparoscopy-assisted total pelvic exenteration combined with pubic resection. ( 27860404 )
2016
35
Metastatic alveolar soft part sarcoma of the lung: Metastatic alveolar soft part sarcoma of the lung-a morphologic pitfall on cytology and aberrant CD10 expression on histology. ( 26693959 )
2016
36
Alveolar soft-part sarcoma in the left forearm with cardiac metastasis: A case report and literature review. ( 26870171 )
2016
37
Treatment of Metastatic, Refractory Alveolar Soft Part Sarcoma: Case Reports and Literature Review of Treatment Options in the Era of Targeted Therapy. ( 27164526 )
2016
38
Primary alveolar soft part sarcoma of uterine corpus: a case report with immunohistochemical, ultrastructural study and review of literature. ( 26837430 )
2016
39
Primary Intracranial Alveolar Soft-Part Sarcoma: Report of Two Cases and a Review ofA theA Literature. ( 26862023 )
2016
40
Metastatic Alveolar Soft Part Sarcoma Responsive to Pazopanib after Progression through Sunitinib and Bevacizumab: Two Cases. ( 27920695 )
2016
41
Prognostic factors in alveolar soft part sarcoma: A SEER analysis. ( 26804150 )
2016
42
Modeling Alveolar Soft Part Sarcoma Unveils Novel Mechanisms of Metastasis. ( 27979841 )
2016
43
Alveolar soft part sarcoma presenting as a breast metastasis in a patient with a history of thyroid cancer: a case report. ( 26464747 )
2015
44
Biologic Activity of Autologous, Granulocyte-Macrophage Colony Stimulating Factor Secreting Alveolar Soft Parts Sarcoma and Clear Cell Sarcoma Vaccines. ( 25805798 )
2015
45
Clinical presentation and CT/MRI findings of alveolar soft part sarcoma: a retrospective single-center analysis of 14 cases. ( 26231949 )
2015
46
Validation and utilization of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinoma and alveolar soft part sarcoma. ( 26415891 )
2015
47
Nasal obstruction and epistaxis. Nasal alveolar soft part sarcoma. ( 25742629 )
2015
48
Recurrent Alveolar Soft Part Sarcoma on Bone Scintigraphy. ( 26447387 )
2015
49
Alveolar soft part sarcoma: Clinicopathological analysis and imaging results. ( 26722241 )
2015
50
Alveolar soft part sarcoma of lung: report of a unique case with emphasis on diagnostic utility of molecular genetic analysis for TFE3 gene rearrangement and immunohistochemistry for TFE3 antigen expression. ( 26369552 )
2015

Variations for Alveolar Soft-Part Sarcoma

Cosmic variations for Alveolar Soft-Part Sarcoma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10667 TP53 soft tissue,liver,sarcoma,NS c.646G>A p.V216M 19
2 COSM44190 TP53 soft tissue,liver,sarcoma,NS c.359A>T p.K120M 19
3 COSM520 KRAS soft tissue,lung,sarcoma,NS c.35G>T p.G12V 19
4 COSM487 HRAS soft tissue,neck,sarcoma,NS c.37G>A p.G13S 19

Expression for Alveolar Soft-Part Sarcoma

Search GEO for disease gene expression data for Alveolar Soft-Part Sarcoma.

Pathways for Alveolar Soft-Part Sarcoma

Pathways related to Alveolar Soft-Part Sarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.46 MET TCF3 VIM
2 11.18 ASPSCR1 MET TCF3 TFE3
3 11.02 MYOD1 TCF3 TFE3

GO Terms for Alveolar Soft-Part Sarcoma

Biological processes related to Alveolar Soft-Part Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of myoblast differentiation GO:0045663 9.37 MYF6 MYOD1
2 positive regulation of myoblast fusion GO:1901741 9.32 MYF6 MYOD1
3 intermediate filament organization GO:0045109 9.26 DES VIM
4 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYF6 MYOD1
5 muscle cell fate commitment GO:0042693 8.96 MYF6 MYOD1
6 positive regulation of muscle cell differentiation GO:0051149 8.8 MYF6 MYOD1 TCF3

Molecular functions related to Alveolar Soft-Part Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.46 MYF6 MYOD1 TCF3 TFE3
2 protein dimerization activity GO:0046983 9.26 MYF6 MYOD1 TCF3 TFE3
3 E-box binding GO:0070888 8.8 MYF6 MYOD1 TCF3

Sources for Alveolar Soft-Part Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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