MCID: ALZ034
MIFTS: 100

Alzheimer Disease malady

Genetic diseases, Rare diseases, Mental diseases, Neuronal diseases categories

Summaries for Alzheimer Disease

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OMIM:45 Alzheimer disease is the most common form of progressive dementia in the elderly. It is a neurodegenerative disorder... (104300) more...

MalaCards based summary: Alzheimer Disease, also known as alzheimer's disease, is related to dementia and vascular dementia, and has symptoms including autosomal dominant inheritance, dementia and parkinsonism. An important gene associated with Alzheimer Disease is APP (amyloid beta (A4) precursor protein), and among its related pathways are Hemostasis and Alzheimers Disease Pathway. The drugs selegiline and selegiline hydrochloride and the compounds serine and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are homeostasis/metabolism and immune system.

Disease Ontology:9 A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. it is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

NIH Rare Diseases:41 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

MedlinePlus:32 Alzheimer's disease (ad) is the most common form of dementia among older people. dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. ad begins slowly. it first involves the parts of the brain that control thought, memory and language. people with ad may have trouble remembering things that happened recently or names of people they know. a related problem, mild cognitive impairment (mci), causes more memory problems than normal for people of the same age. many, but not all, people with mci will develop ad. in ad, over time, symptoms get worse. people may not recognize family members or have trouble speaking, reading or writing. they may forget how to brush their teeth or comb their hair. later on, they may become anxious or aggressive, or wander away from home. eventually, they need total care. this can cause great stress for family members who must care for them. ad usually begins after age 60. the risk goes up as you get older. your risk is also higher if a family member has had the disease. no treatment can stop the disease. however, some drugs may help keep symptoms from getting worse for a limited time. nih: national institute on aging

CDC:3 Although scientists are learning more every day, right now, they still do not know what causes Alzheimer’s disease.

NINDS:42 Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.

Genetics Home Reference:21 Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.

Wikipedia:63 Alzheimer\'s disease (AD), also known as Alzheimer disease, or just Alzheimer\'s, accounts for 60% to... more...

GeneReviews summary for alzheimer

Aliases & Classifications for Alzheimer Disease

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Alzheimer Disease, Aliases & Descriptions:

Name: Alzheimer Disease 45 9 19 41 21 30
Alzheimer's Disease 30 9 63 20 21 42 32 3 60
Familial Alzheimer Disease 63 41 21 60
Alzheimer Disease 8 45 10 60
Alzheimers Disease 11 43 22
Ad 9 63 21
Primary Senile Degenerative Dementia 63 21
Alzheimer Disease 1, Familial 45 10
Presenile and Senile Dementia 63 21
Alzheimer Disease-10 45 10
Alzheimer Disease 6 45 10
Alzheimer Disease-5 45 20
Sdat 63 21
Alzheimer Disease, Pathogenesis, Association with 45
Dementia Due to Alzheimer's Disease 60
Alzheimer's Disease Pathway Kegg 60
 
Dat - Dementia Alzheimer's Type 63
Alzheimer Disease 9, Late Onset 45
Alzheimer Disease 6, Late-Onset 60
Alzheimer Disease, Late-Onset 45
Alzheimer Disease Familial 41
Alzheimer-Type Dementia 21
Alzheimer Disease 10 60
Alzheimer Sclerosis 21
Alzheimer Disease 5 60
Alzheimers Dementia 9
Alzheimer Syndrome 21
Alzheimer Dementia 21
Medullar Disease 41
Dat 21
Fad 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases, Neuronal diseases


External Ids:

OMIM45 104300
Disease Ontology9 DOID:10652
ICD9CM27 331.0

Related Diseases for Alzheimer Disease

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Diseases in the Alzheimer Disease family:

Alzheimer Disease 17 Alzheimer Disease 12
Alzheimer Disease 18 Alzheimer Disease 16
Alzheimer Disease-4 Alzheimer Disease, Type 3
Alzheimer Disease-2 Alzheimer Disease 19, Late Onset
Alzheimer Disease Type 1 Alzheimer Disease Risk Factor
Early-Onset Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 470)
idRelated DiseaseScoreTop Affiliating Genes
1dementia32.3BLMH, APOE, APP, PSEN1, PSEN2
2vascular dementia32.0APOE, APP, PSEN1
3alzheimer disease-232.0APOE, APP, PSEN1, PSEN2, PLAU, NOS3
4alzheimer disease type 131.9PSEN2, PSEN1, APP
5cerebral amyloid angiopathy31.8PSEN1, APP, APOE
6down syndrome31.8PSEN2, PSEN1, APP, APOE
7cerebrovascular disease31.5APOE, APP, ACE
8amyloidosis31.4APOE, APP, PSEN1, PSEN2
9tauopathy31.3PSEN1, APP
10coronary artery disease31.2APOE, ACE, HFE, NOS3
11pick disease31.2APOE, APP, PSEN1
12prion disease31.1PSEN2, PSEN1, APP, APOE
13inclusion body myositis31.1APP
14huntington disease31.0PSEN2, PSEN1, APP
15dementia, frontotemporal30.9APOE, APP, PSEN1, PSEN2
16supranuclear palsy, progressive30.9APP, APOE
17atherosclerosis30.8APOE, MPO, SORL1, ACE, PLAU, NOS3
18parkinson disease, late-onset30.8APOE, APP, PSEN1, MT-ND1
19myocardial infarction30.7APOE, ACE, HFE, NOS3
20proteinuria30.7MPO, ACE, NOS3
21vascular disease30.6APOE, PSEN1, ACE, NOS3
22dementia, lewy body30.6APOE, APP
23creutzfeldt-jakob disease30.4APP, APOE
24hyperlipidemia type 310.8
25neuronitis10.8
26cerebritis10.7
27hereditary cerebral amyloid angiopathy10.6APP
28binswanger's disease10.6APP, APOE
29hemorrhage, intracerebral10.6APP, APOE
30microvascular complications of diabetes 310.6NOS3, HFE, ACE, APOE
31microvascular complications of diabetes 710.6HFE
32teratocarcinoma10.6PLAU, PSEN1, APP
33astrocytoma10.6APP, PSEN1, PSEN2, PLAU
34stroke, ischemic10.6APOE, PSEN1, ACE, NOS3
35diabetes mellitus, insulin-dependent10.6APOE, MT-ND1, ACE, HFE, NOS3
36diabetes mellitus, noninsulin-dependent10.6NOS3, ACE, MT-ND1, APOE
37nephrotic syndrome10.6A2M, ACE, APOE
38hypercholesterolemia, familial10.6NOS3, ACE, APOE
39primary hyperoxaluria10.6APOE, ACE, HFE, NOS3
40alzheimer disease, type 310.6
41congenital heart disease10.5NOS3, ACE, MPO
42porphyria cutanea tarda10.5HFE
43noonan syndrome 110.5HFE, ACE, MT-ND1
44amyotrophic lateral sclerosis 110.5PSEN1, APP
45alzheimer disease-410.5
46hypertension, essential10.4APOE, ACE, NOS3
47early-onset autosomal dominant alzheimer disease10.4
48spastic paraparesis10.3
49spasticity10.3
50blindness10.3

Graphical network of the top 20 diseases related to Alzheimer Disease:



Diseases related to alzheimer disease

Symptoms for Alzheimer Disease

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Symptoms by clinical synopsis from OMIM:

104300

Clinical features from OMIM:

104300

HPO human phenotypes related to Alzheimer Disease:

(show all 12)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 dementia HP:0000726
3 parkinsonism HP:0001300
4 heterogeneous HP:0001425
5 neurofibrillary tangles HP:0002185
6 long-tract signs HP:0002423
7 alzheimer disease HP:0002511
8 late onset HP:0003584
9 personality changes HP:0000751
10 cerebral cortical atrophy HP:0002120
11 neurological speech impairment HP:0002167
12 memory impairment HP:0002354

Drugs & Therapeutics for Alzheimer Disease

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Drug clinical trials:

Search ClinicalTrials for Alzheimer Disease

Search NIH Clinical Center for Alzheimer Disease

Inferred drug relations via UMLS60/NDF-RT39:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alzheimer Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alzheimer Disease:
NEUROSTEM
Embryonic/Adult Cultured Cells Related to Alzheimer Disease:
Umbilical cord blood-derived mesenchymal stem/progenitor cells , PMIDs: 23293711, 22015609

Genetic Tests for Alzheimer Disease

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Genetic tests related to Alzheimer Disease:

id Genetic test Affiliating Genes
1 Alzheimer Disease20
2 Alzheimer Disease Type 520 AD5
3 Alzheimer's Disease22

Anatomical Context for Alzheimer Disease

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MalaCards organs/tissues related to Alzheimer Disease:

31
Liver, Brain, Lung, Cortex, Endothelial, Prostate, Skeletal muscle, Testes, T cells, Kidney, Thyroid, Myeloid, B cells, Skin, Smooth muscle, Pons, Temporal lobe, Cerebellum, Spinal cord, Fetal brain, Prefrontal cortex, Amygdala

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alzheimer Disease:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
3 BrainHippocampus  Affected by disease

Animal Models for Alzheimer Disease or affiliated genes

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MGI Mouse Phenotypes related to Alzheimer Disease:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9NOS3, APOE, APP, MPO, SORL1, PSEN1
2MP:000538710.9ACE, BLMH, APOE, APP, MPO, PSEN1
3MP:001076810.9NOS3, MPO, PLAU, ACE, PSEN2, PSEN1
4MP:000538510.9BLMH, APOE, MPO, SORL1, PSEN1, PSEN2
5MP:000537810.8APOE, HFE, NOS3, BLMH, APBB2, PSEN1
6MP:000539510.8SORL1, APP, PSEN1, NOS3, APOE
7MP:000536910.8PLAU, APOE, APP, MPO, SORL1, PSEN1
8MP:000538410.7ACE, HFE, PLAU, PSEN2, NOS3, PSEN1
9MP:000537110.7HFE, NOS3, BLMH, APOE, PSEN1, PSEN2
10MP:000363110.7PSEN1, SORL1, PSEN2, APOE, PLAU, APBB2
11MP:000539710.6APOE, MPO, HFE, PSEN1, PSEN2, PLAU
12MP:000537910.6APOE, NOS3, PSEN1, ACE, PLAU, PSEN2
13MP:000538610.5HFE, NOS3, ACE, PSEN2, PSEN1, APP
14MP:000538110.3HFE, NOS3, PLAU, PSEN2, APOE, PSEN1

Publications for Alzheimer Disease

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Articles related to Alzheimer Disease:

(show top 50)    (show all 1200)
idTitleAuthorsYear
1
Levels of soluble apolipoprotein E/amyloid-I^ (AI^) complex are reduced and oligomeric AI^ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. (23293020)
2013
2
Risk of incident stroke in patients with Alzheimer disease or vascular dementia. (23902701)
2013
3
Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the PSEN1 gene. (22882713)
2013
4
Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. (23048024)
2012
5
Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3I^ (GSK3I^) activity: novel mechanism for Pin1 to protect against Alzheimer disease. (22184106)
2012
6
Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease. (22190428)
2012
7
Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease. (21228296)
2011
8
Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population. (20625269)
2010
9
Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: evidence for Abeta(25-35). (19751725)
2010
10
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi. (20448481)
2010
11
Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients. (20160457)
2010
12
Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. (18931004)
2009
13
Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease. (18379441)
2008
14
Oligomeric beta-amyloid(1-42) induces the expression of Alzheimer disease-relevant proteins in cholinergic SN56.B5.G4 cells as revealed by proteomic analysis. (18325718)
2008
15
Expression and phosphorylation of protein kinase C isoforms in Abeta(1-42) activated T lymphocytes from Alzheimers disease. (18336728)
2008
16
Heritability of magnetic resonance imaging (MRI) traits in Alzheimer disease cases and their siblings in the MIRAGE study. (17545732)
2007
17
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. (17505559)
2007
18
epsilon-Glycation, APP and Abeta in ageing and Alzheimer disease: a hypothesis. (16442744)
2006
19
The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease. (16652347)
2006
20
Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease. (16195223)
2006
21
Ferric cycle activity and Alzheimer disease. (16181119)
2005
22
An African American family with early-onset Alzheimer disease and an APP (T714I) mutation. (15668448)
2005
23
Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease. (16027741)
2005
24
The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease. (15835262)
2005
25
Abnormalities of peptide metabolism in Alzheimer disease. (16181081)
2004
26
Prion protein codon 129 polymorphism and risk of Alzheimer disease. (15277640)
2004
27
A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. (15534188)
2004
28
Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model. (15229191)
2004
29
DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. (12890786)
2003
30
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. (12783912)
2003
31
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (12364720)
2002
32
Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains. (11849755)
2002
33
Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease. (12433268)
2002
34
The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset. (12095653)
2002
35
The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease. (11559314)
2001
36
Alzheimer disease: mouse models pave the way for therapeutic opportunities. (10681074)
2000
37
Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. (10439473)
1999
38
Germline mutational analysis of presenilin 1 and APP genes in Jewish-Israeli individuals with familial or early-onset Alzheimer disease using denaturing gradient gel electrophoresis (DGGE). (9781063)
1998
39
Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease. (9536099)
1998
40
Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease. (9341576)
1997
41
Aging, metabolism, and Alzheimer disease: review and hypotheses. (9000448)
1997
42
Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease. (9148245)
1997
43
Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls. (8813351)
1996
44
Selegiline in treatment of behavioral and cognitive symptoms of Alzheimer disease. (8998375)
1996
45
Synaptotagmin, a synaptic vesicle protein, is present in human cerebrospinal fluid: a new biochemical marker for synaptic pathology in Alzheimer disease? (8962603)
1996
46
Apolipoprotein E and Alzheimer disease. (7761390)
1995
47
Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: a potential diagnostic biochemical marker. (1361232)
1992
48
Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. (1652752)
1991
49
Neurofibrillary tangles of the Indiana kindred of Gerstmann-StrAoussler-Scheinker disease share antigenic determinants with those of Alzheimer disease. (2176119)
1990
50
Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease. (1977892)
1990

Variations for Alzheimer Disease

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UniProtKB/Swiss-Prot genetic disease variations for Alzheimer Disease:

62 (show all 13)
id Symbol AA change Variation ID SNP ID
1APPp.Ala692GlyVAR_000016
2APPp.Ala713ThrVAR_000019
3APPp.Ile716ValVAR_000020
4APPp.Val717IleVAR_000021
5APPp.Val717GlyVAR_000022
6APPp.Val717PheVAR_000023
7APPp.Val715MetVAR_010108
8APPp.Leu723ProVAR_010109
9APPp.Glu693GlyVAR_014215
10APPp.Thr714IleVAR_014218
11APPp.Val717LeuVAR_014219
12APPp.Thr714AlaVAR_032277
13APPp.Asp678AsnVAR_044424

Clinvar genetic disease variations for Alzheimer Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1APPNM_000484.3(APP): c.2149G> A (p.Val717Ile)single nucleotide variantPathogenicrs63750264GRCh37Chr 21, 27264096: 27264096
2APPNM_000484.3(APP): c.2075C> G (p.Ala692Gly)single nucleotide variantPathogenicrs63750671GRCh37Chr 21, 27264170: 27264170
3APPNM_000484.3(APP): c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu)indelPathogenicrs281865161GRCh37Chr 21, 27269938: 27269939
4APPNM_000484.3(APP): c.2078A> G (p.Glu693Gly)single nucleotide variantPathogenicrs63751039GRCh37Chr 21, 27264167: 27264167
5APPNM_000484.3(APP): c.2018C> T (p.Ala673Val)single nucleotide variantPathogenicrs193922916GRCh37Chr 21, 27269931: 27269931
6HFENM_000410.3(HFE): c.845G> A (p.Cys282Tyr)single nucleotide variantPathogenic, confers sensitivity, risk factorrs1800562GRCh37Chr 6, 26093141: 26093141
7MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Alzheimer Disease

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LifeMap Discovery
Genes differentially expressed in tissues of Alzheimer Disease patients vs. healthy controls: 30 (show all 68)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1FOSFBJ murine osteosarcoma viral oncogene homologLiver-6.750.000
2KCNN2potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2Liver-6.110.000
3FOSBFBJ murine osteosarcoma viral oncogene homolog BLiver-5.080.000
4CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 2Liver-4.910.000
5NR4A2nuclear receptor subfamily 4, group A, member 2Liver-4.850.000
6GNMTglycine N-methyltransferaseLiver-4.500.000
7PCOLCE2procollagen C-endopeptidase enhancer 2Liver-4.480.000
8CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 19Liver-4.450.000
9ORM1orosomucoid 1Lung-4.190.014
10MT1Mmetallothionein 1MLiver-4.070.000
11PPP1R1Aprotein phosphatase 1, regulatory (inhibitor) subunit 1ALiver-3.910.000
12DUSP1dual specificity phosphatase 1Liver-3.890.000
13LOC100133131uncharacterized LOC100133131Blood+3.830.000
14LGSNlengsin, lens protein with glutamine synthetase domainLiver-3.780.000
15SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1Liver-3.770.000
16AC074289.1uncharacterized LOC100507006Brain+3.730.000
17SLC17A8solute carrier family 17 (vesicular glutamate transporter), member 8Blood+3.710.001
18AZU1azurocidin 1Blood+3.700.024
19CLEC4MC-type lectin domain family 4, member MLiver-3.690.000
20CNDP1carnosine dipeptidase 1 (metallopeptidase M20 family)Liver-3.650.000
21GPR88G protein-coupled receptor 88Liver-3.640.000
22GADD45Ggrowth arrest and DNA-damage-inducible, gammaLiver-3.590.000
23CXCL3chemokine (C-X-C motif) ligand 3Blood+3.590.004
24BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1Liver-3.560.000
25ARPP21cAMP-regulated phosphoprotein, 21kDaBlood+3.550.004
26KITLGKIT ligandBlood+3.530.001
27OATornithine aminotransferaseLiver-3.470.000
28EPB41L4Berythrocyte membrane protein band 4.1 like 4BLiver-3.470.000
29PZPpregnancy-zone proteinLiver-3.450.000
30NAMPTnicotinamide phosphoribosyltransferaseLiver-3.450.000
31PDE1Cphosphodiesterase 1C, calmodulin-dependent 70kDaBlood+3.370.016
32IDO2indoleamine 2,3-dioxygenase 2Liver-3.360.000
33MMEmembrane metallo-endopeptidaseLiver-3.340.000
34SDSserine dehydrataseLiver-3.330.016
35AKR1D1aldo-keto reductase family 1, member D1Liver-3.290.000
36MT1Gmetallothionein 1GBrain+3.290.000
37ALAS2aminolevulinate, delta-, synthase 2Blood+3.280.010
38HAO2hydroxyacid oxidase 2 (long chain)Liver-3.280.000
39SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6DBlood+3.250.020
40RGS1regulator of G-protein signaling 1Liver-3.240.000
41SORL1sortilin-related receptor, L(DLR class) A repeats containingLiver-3.240.000
42SRD5A2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)Liver-3.220.000
43LPAlipoprotein, Lp(a)Liver-3.220.001
44CD5LCD5 molecule-likeLiver-3.200.001
45SLC4A1solute carrier family 4 (anion exchanger), member 1 (Diego blood group)Blood+3.200.001
46FOSBFBJ murine osteosarcoma viral oncogene homolog BLung+3.190.008
47RPS27ribosomal protein S27Liver-3.190.000
48B4GALT1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1Liver-3.180.000
49TNS1tensin 1Blood+3.180.002
50ZNF425zinc finger protein 425Blood+3.170.006
51RBPMS2RNA binding protein with multiple splicing 2Blood+3.160.012
52SIK1salt-inducible kinase 1Liver-3.160.000
53SSTR1somatostatin receptor 1Liver-3.150.000
54FAM170Bfamily with sequence similarity 170, member BBlood+3.150.000
55EGR1early growth response 1Liver-3.120.000
56CSRNP1cysteine-serine-rich nuclear protein 1Liver-3.120.000
57CYP1A1cytochrome P450, family 1, subfamily A, polypeptide 1Liver-3.120.000
58GADD45Bgrowth arrest and DNA-damage-inducible, betaLiver-3.110.000
59GNG13guanine nucleotide binding protein (G protein), gamma 13Blood+3.090.004
60IL1RAPinterleukin 1 receptor accessory proteinLiver-3.090.000
61AGAP11ankyrin repeat and GTPase domain Arf GTPase activating protein 11Blood+3.060.009
62PDK4pyruvate dehydrogenase kinase, isozyme 4Liver-3.060.000
63FREM1FRAS1 related extracellular matrix 1Blood+3.040.001
64SLC35D3solute carrier family 35, member D3Blood+3.040.048
65CFHR3complement factor H-related 3Liver-3.040.000
66FSTfollistatinLiver-3.040.000
67SLCO1B3solute carrier organic anion transporter family, member 1B3Liver-3.020.002
68SLC16A10solute carrier family 16 (aromatic amino acid transporter), member 10Liver-3.010.000

Search GEO for disease gene expression data for Alzheimer Disease.

Pathways for genes affiliated with Alzheimer Disease

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Pathways related to Alzheimer Disease according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.6APP, PLAU, A2M, NOS3
210.6A2M, PSEN2, PSEN1, APP, APOE
310.5APOE, APP, ACE, A2M
4
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
10.5PSEN1, PSEN2, PLAU, NOS3
510.5APP, PSEN1, PSEN2, ACE
610.5PSEN2, PSEN1, APP, APOE
7
Show member pathways
Alzheimers Disease36
10.5PSEN2, PSEN1, APP, APOE
8
Show member pathways
Delta-Notch Signaling Pathway36
Notch Signaling Pathway36
10.5APP, PSEN1, PSEN2
910.5PSEN2, PSEN1, APP
10
Show member pathways
10.5NOS3, ACE
1110.5PSEN2, PSEN1

Compounds for genes affiliated with Alzheimer Disease

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Compounds related to Alzheimer Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1serine4311.1PLAU, MPO, APP, NOS3, PSEN2, MT-ND1
2h2o24311.0APP, NOS3, PLAU, PSEN2, PSEN1, MPO
3cholesterol43 28 24 1214.0HFE, ACE, PSEN2, PSEN1, APOE, APP
4valine4311.0APOE, APP, MT-ND1, PSEN2, PSEN1, MPO
5aspirin43 49 28 2414.0NOS3, PLAU, ACE, APOE, APP
6aspartate4311.0PSEN2, PLAU, APOE, APP, PSEN1, HFE
7kininogen4311.0ACE, MPO, PLAU, APP
8acetylcholine43 49 28 24 1215.0NOS3, ACE, MPO, APP, APOE
9vegf4311.0MPO, PSEN2, PLAU, NOS3, APOE, APP
10sodium dodecylsulfate4311.0PLAU, NOS3, APOE, APP
11bleomycin43 1212.0BLMH, PSEN1, NOS3, APOE
124-hydroxynonenal43 2412.0APP, MPO, PSEN1, APOE
13aebsf4311.0PLAU, NOS3, APP
14actinomycin d4311.0APP, APOE, NOS3, PLAU, PSEN2
15atorvastatin43 49 28 24 1215.0PLAU, ACE, NOS3, APOE
16lactacystin4311.0APOE, APP, PSEN1, PSEN2
17choline43 24 1212.9NOS3, PSEN2, PSEN1, APP
18glutamate4310.9NOS3, PSEN2, PSEN1, APOE, PLAU, APP
19ab-424310.9PSEN2, APP
20alanine4310.9HFE, APOE, PSEN1, MT-ND1, PLAU, APP
21thapsigargin43 5911.9PLAU, APP, PSEN1, NOS3
22folate4310.9NOS3, APOE, PSEN1, APP
23prostacyclin4310.9APOE, ACE, NOS3, PLAU
24lactate4310.9PLAU, MT-ND1, PSEN2, MPO, BLMH
25s-1824310.9PSEN2, PSEN1
26creatinine4310.9APP, ACE, PLAU, MPO, APOE
27l-685,4585910.9PSEN1, PSEN2
28begacestat5910.9PSEN2, PSEN1
29dapt5910.9PSEN1, PSEN2
30heparin43 28 24 1213.9A2M, APP, MPO, PLAU, APOE
31mrk 5605910.9PSEN1, PSEN2
32jlk 65910.9PSEN2, PSEN1
33celiprolol4310.9ACE, NOS3
34raloxifene43 49 28 1213.8NOS3, PSEN2, PLAU
35xanthine43 2411.8MPO, NOS3, PLAU
36thioflavine s4310.8APOE, APP
37beta blocking agents4910.8NOS3, ACE
38retinoic acid43 2411.8NOS3, APP, PLAU, MPO, PSEN2, PSEN1
39metrifonate4310.8APP, APOE
40oxypurinol4310.8NOS3, MPO
41cysteine4310.8PLAU, PSEN1, HFE, BLMH, APP, APOE
42dihydralazine4310.8ACE, MPO
43fluvastatin43 49 28 1213.7NOS3, ACE, APOE
44vitamin b124310.7MPO, PSEN1, APOE
4524s-hydroxy-cholesterol4310.6APP, APOE
46peroxynitrite4310.6NOS3, PSEN1, MPO
47ascorbic acid43 2411.5APOE, MPO, HFE, NOS3
48mechlorethamine4310.5PLAU, MPO
49indomethacin43 28 59 1213.4APOE, MPO, PLAU, NOS3
50nebivolol43 1211.2ACE, NOS3

GO Terms for genes affiliated with Alzheimer Disease

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Cellular components related to Alzheimer Disease according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:007006210.8BLMH, APOE, APP, MPO, SORL1, ACE
2ciliary rootletGO:003525310.8PSEN2, PSEN1, APP
3dendritic shaftGO:004319810.8PSEN2, PSEN1, APP
4neuromuscular junctionGO:003159410.7APP, PSEN1, PSEN2
5integral component of plasma membraneGO:000588710.7HLA-H, APP, SORL1, PSEN1, PSEN2, HFE
6neuronal cell bodyGO:004302510.7APOE, SORL1, PSEN1, PSEN2
7growth coneGO:003042610.6APBB2, PSEN1, PSEN2
8MHC class I protein complexGO:004261210.6HFE, HLA-H
9Golgi apparatusGO:000579410.6APOE, APP, SORL1, PSEN1, PSEN2
10axonGO:003042410.5PSEN2, PSEN1, APP
11low-density lipoprotein particleGO:003436210.4SORL1, APOE
12cell surfaceGO:000998610.2APP, PSEN1, PSEN2, PLAU

Biological processes related to Alzheimer Disease according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1regulation of smooth muscle cell migrationGO:001491010.9PLAU, ACE, SORL1
2cholesterol metabolic processGO:000820310.9SORL1, APP, APOE
3smooth endoplasmic reticulum calcium ion homeostasisGO:005156310.9PSEN1, APP
4positive regulation of coagulationGO:005082010.9PSEN2, PSEN1
5regulation of epidermal growth factor-activated receptor activityGO:000717610.9PSEN2, APP
6extracellular matrix organizationGO:003019810.9A2M, PSEN1, APP, APBB2
7myeloid leukocyte differentiationGO:000257310.9PSEN1, PSEN2
8response to oxidative stressGO:000697910.8APP, MPO, PSEN1
9amyloid precursor protein catabolic processGO:004298710.8PSEN1, PSEN2
10negative regulation of platelet activationGO:001054410.8NOS3, APOE
11endoplasmic reticulum calcium ion homeostasisGO:003246910.8PSEN1, PSEN2
12beta-amyloid metabolic processGO:005043510.8PSEN2, PSEN1
13antigen processing and presentation of peptide antigen via MHC class IGO:000247410.8HFE, BLMH, HLA-H
14anagenGO:004264010.8PSEN1, PSEN2
15low-density lipoprotein particle remodelingGO:003437410.8APOE, MPO
16dorsal/ventral neural tube patterningGO:002190410.8PSEN1, PSEN2
17brain morphogenesisGO:004885410.8PSEN1, PSEN2
18hematopoietic progenitor cell differentiationGO:000224410.7PSEN1, PSEN2
19Notch signaling pathwayGO:000721910.7PSEN2, PSEN1, APP
20cell fate specificationGO:000170810.7PSEN1, PSEN2
21nitric oxide mediated signal transductionGO:000726310.7APOE, NOS3
22regulation of protein bindingGO:004339310.7PSEN1, APP
23T cell activation involved in immune responseGO:000228610.6PSEN2, PSEN1
24negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:0190204210.6NOS3, PSEN2
25blood coagulationGO:000759610.6NOS3, A2M, PLAU, APP
26membrane protein ectodomain proteolysisGO:000650910.5PSEN1, PSEN2
27positive regulation of T cell mediated cytotoxicityGO:000191610.4HLA-H, HFE
28Notch receptor processingGO:000722010.2PSEN2, PSEN1

Molecular functions related to Alzheimer Disease according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:000551510.8BLMH, APOE, APBB2, APP, SORL1, PSEN1
2endopeptidase activityGO:000417510.7ACE, PSEN2, PSEN1
3carboxypeptidase activityGO:000418010.6ACE, BLMH
4heparin bindingGO:000820110.5APOE, APP, MPO
5peptide antigen bindingGO:004260510.5HFE, HLA-H
6aspartic-type endopeptidase activityGO:000419010.4PSEN2, PSEN1
7beta-amyloid bindingGO:000154010.2APBB2, APOE

Products for genes affiliated with Alzheimer Disease

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Sources for Alzheimer Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
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39NDF-RT
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43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet