Alzheimer Disease malady
Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases
50OMIM, 33LifeMap Discovery®, 11Disease Ontology, 69Wikipedia, 22GeneReviews, 46NIH Rare Diseases, 23GeneTests, 24Genetics Home Reference, 47NINDS, 13DISEASES, 68UniProtKB/Swiss-Prot, 25GTR, 12diseasecard, 48Novoseek, 36MedlinePlus, 2CDC, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 43NCIt, 35MedGen, 60SNOMED-CT, 62The Human Phenotype Ontology
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Aliases & Descriptions for Alzheimer Disease:
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases, Neuronal diseases
OMIM:50 Alzheimer disease is the most common form of progressive dementia in the elderly. It is a neurodegenerative disorder... (104300) more...
MalaCards based summary: Alzheimer Disease, also known as alzheimer's disease, is related to alzheimer disease-4 and pick disease, and has symptoms including back pain, back pain and headache. An important gene associated with Alzheimer Disease is APP (Amyloid Beta Precursor Protein), and among its related pathways are Neuroscience and Alzheimers Disease Pathway. The drugs galantamine and selegiline have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are immune system and hematopoietic system.
Disease Ontology:11 A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. it is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.
NIH Rare Diseases:46 Alzheimer disease (ad) is a degenerative disease of the brain that causes gradual loss of memory, judgment, and the ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic cases of alzheimer disease begin after age 65, and the risk of developing this condition increases as a person gets older. ad can be subdivided into two groups based on the age of onset: (1) early-onset (1%-6% of the cases) which start in people younger than 60- 65 years of age (2) late-onset, which starts in people older than 65 years old. in about 25% of cases, ad is familial (2 or more people in a family have ad). for more information, please visit gard's familial alzheimer disease web page. last updated: 11/2/2015
UniProtKB/Swiss-Prot:68 Alzheimer disease: Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C- terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. Alzheimer disease 1: A familial early-onset form of Alzheimer disease. It can be associated with cerebral amyloid angiopathy. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
MedlinePlus:36 Alzheimer's disease (ad) is the most common form of dementia among older people. dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. ad begins slowly. it first involves the parts of the brain that control thought, memory and language. people with ad may have trouble remembering things that happened recently or names of people they know. a related problem, mild cognitive impairment (mci), causes more memory problems than normal for people of the same age. many, but not all, people with mci will develop ad. in ad, over time, symptoms get worse. people may not recognize family members. they may have trouble speaking, reading or writing. they may forget how to brush their teeth or comb their hair. later on, they may become anxious or aggressive, or wander away from home. eventually, they need total care. this can cause great stress for family members who must care for them. ad usually begins after age 60. the risk goes up as you get older. your risk is also higher if a family member has had the disease. no treatment can stop the disease. however, some drugs may help keep symptoms from getting worse for a limited time. nih: national institute on aging
CDC:2 Although scientists are learning more every day, right now, they still do not know what causes Alzheimer’s disease.
NINDS:47 Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.
Genetics Home Reference:24 Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.
Wikipedia:69 Alzheimer\'s disease (AD), also known as just Alzheimer\'s, is a chronic neurodegenerative disease that... more...
GeneReviews summary for NBK1161
HPO human phenotypes related to Alzheimer Disease:(show all 10)
UMLS symptoms related to Alzheimer Disease:back pain, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, equilibration disorder, sleeplessness, personality change
Drugs for Alzheimer Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 311)
Interventional clinical trials:(show top 50) (show all 1995)
Search NIH Clinical Center for Alzheimer Disease
Inferred drug relations via UMLS66/NDF-RT44:Show with subtypes
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alzheimer Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alzheimer Disease:
Embryonic/Adult Cultured Cells Related to Alzheimer Disease:
MalaCards organs/tissues related to Alzheimer Disease:34
Brain, Testes, Cortex, Endothelial, Prostate, Eye, Skeletal muscle
Data from LifeMap, the Embryonic Development and Stem Cells Database
Cells/anatomical compartments in embryo or adult related to Alzheimer Disease:
MGI Mouse Phenotypes related to Alzheimer Disease:39 (show all 13)
Articles related to Alzheimer Disease:(show top 50) (show all 1366)
UniProtKB/Swiss-Prot genetic disease variations for Alzheimer Disease:68 (show all 13)
Clinvar genetic disease variations for Alzheimer Disease:5
Copy number variations for Alzheimer Disease from CNVD:6 (show all 34)
Search GEO for disease gene expression data for Alzheimer Disease.
Pathways related to Alzheimer Disease according to KEGG:32
Pathways related to Alzheimer Disease according to GeneCards Suite gene sharing:
Cellular components related to Alzheimer Disease according to GeneCards Suite gene sharing:
Biological processes related to Alzheimer Disease according to GeneCards Suite gene sharing:(show all 21)
Molecular functions related to Alzheimer Disease according to GeneCards Suite gene sharing:(show all 7)
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet