Alzheimer Disease 12

Categories: Neuronal diseases, Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Alzheimer Disease 12

MalaCards integrated aliases for Alzheimer Disease 12:

Name: Alzheimer Disease 12 54 12 13 69
Alzheimer Disease Familial 12 12
Alzheimer's Disease 12 12
Ad12 12


External Ids:

OMIM 54 611073
Disease Ontology 12 DOID:0110045
ICD10 33 G30

Summaries for Alzheimer Disease 12

Disease Ontology : 12 An Alzheimer's disease that is characterized by an associated with variation in the region 8p12-q22.

MalaCards based summary : Alzheimer Disease 12, is also known as alzheimer disease familial 12. An important gene associated with Alzheimer Disease 12 is AD12 (Alzheimer Disease 12). The drugs Donepezil and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone.

Description from OMIM: 611073

Symptoms & Phenotypes for Alzheimer Disease 12

Clinical features from OMIM:


Drugs & Therapeutics for Alzheimer Disease 12

Drugs for Alzheimer Disease 12 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 333)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Donepezil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 120014-06-4 3152
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-28-2 5757
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 3 71-58-9
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3 57-83-0 5994
Rivastigmine Approved, Investigational Phase 4,Phase 3,Phase 2 123441-03-2 77991
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
Citalopram Approved Phase 4 59729-33-8 2771
Methylphenidate Approved, Investigational Phase 4,Phase 1,Phase 2 113-45-1 4158
Galantamine Approved Phase 4,Phase 3,Phase 2 357-70-0 9651
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2 13422-51-0 11953898 5460373 44475014
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
Pravastatin Approved Phase 4 81093-37-0 54687
Simvastatin Approved Phase 4 79902-63-9 54454
Warfarin Approved Phase 4,Phase 1 81-81-2 6691 54678486
Dextromethorphan Approved Phase 4,Phase 3,Phase 2,Phase 1 125-71-3 5360696 5362449
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
Quinidine Approved Phase 4,Phase 3,Phase 2 56-54-2 441074
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 68-19-9 44176380
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
Choline Approved, Nutraceutical Phase 4 62-49-7 305
23 Tandospirone Investigational Phase 4 87760-53-0
24 Antiparkinson Agents Phase 4,Phase 3,Phase 2
25 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Cholinesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
29 Excitatory Amino Acids Phase 4,Phase 3,Phase 2,Phase 1
30 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Nootropic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
33 Contraceptive Agents Phase 4,Phase 2,Phase 3,Phase 1
34 Contraceptive Agents, Male Phase 4,Phase 2,Phase 3
35 Estradiol 17 beta-cypionate Phase 4,Phase 2,Phase 3,Phase 1
36 Estradiol 3-benzoate Phase 4,Phase 2,Phase 3,Phase 1
37 Estradiol valerate Phase 4,Phase 2,Phase 3,Phase 1 979-32-8
38 Estrogens Phase 4,Phase 2,Phase 3
39 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
40 Hormones Phase 4,Phase 2,Phase 3,Phase 1
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
Medroxyprogesterone Phase 4,Phase 2,Phase 3 520-85-4 10631
43 Phytoestrogens Phase 4
44 Polyestradiol phosphate Phase 4,Phase 2,Phase 3,Phase 1
45 Progestins Phase 4,Phase 2,Phase 3
46 Neuroprotective Agents Phase 4,Phase 3,Phase 2
47 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Vitamins Phase 4,Phase 3,Phase 1,Phase 2
50 Anesthetics Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 431)

id Name Status NCT ID Phase Drugs
1 Donepezil and Memantine in Moderate to Severe Alzheimer's Disease Unknown status NCT00866060 Phase 4 Memantine;Donepezil;Placebo donepezil;Placebo memantine
2 Memantine for Agitation in Dementia Unknown status NCT00371059 Phase 4 Memantine;Placebo
3 Validation of DaTscan for Detection of Parkinson Disease Related Disorders Unknown status NCT02138682 Phase 4 l-123 Ioflupane
4 Multi-centre Clinical Trial on Hormone Replacement Treatment in China Unknown status NCT01698164 Phase 4 estradiol plus MPA;Ximingting Tablet;estradiol plus progesterone
5 Preventive Treatment of Tacrolimus Ointment in Children With Atopic Dermatitis Completed NCT01745159 Phase 4 tacrolimus
6 A 12 Week, Multicenter, Open Label Evaluation of Caregiver Preference, Safety and Tolerability of Exelon® Patch (Rivastigmine Transdermal) in Patients With Alzheimer's Disease Completed NCT01047579 Phase 4 Rivastigmine transdermal
7 Escitalopram for the Treatment of Depression in Alzheimer's Disease Completed NCT01841125 Phase 4 escitalopram;Placebo
8 Effect of Memantine on Functional Communication in Patients With Alzheimer's Disease Completed NCT00469456 Phase 4 Memantine;placebo
9 EARTH 413: A Study of Aricept in Hispanic Patients With Mild to Moderate Alzheimer's Disease (AD) Completed NCT00230568 Phase 4 Aricept
10 Delaying the Progression of Driving Impairment in Individuals With Mild Alzheimer's Disease Completed NCT00476008 Phase 4 Memantine;Placebo
11 16w Interventional Study on Titration and Dose/Efficacy Assessment of Exelon in Chinese Alzheimer's Disease Patients Completed NCT01948791 Phase 4 ENA713
12 Convenience, Tolerability, and Safety of Change in the Administration of Rivastigmine From Capsules to a Transdermal Patch in Patients With Mild to Moderate Alzheimer's Disease Completed NCT00549601 Phase 4 Rivastigmine patch (4.6 mg/day switch to 9.5 mg/day);Rivastigmine patch (9.5 mg/day);Rivastigmine capsules (6 mg to 12 mg/day)
13 The Effectiveness And Safety Of Donepezil Hydrochloride (E2020) In Subjects With Mild To Severe Alzheimer's Disease Residing In An Assisted Living Facility Completed NCT00571064 Phase 4 Donepezil HCl
14 Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study Completed NCT00495820 Phase 4 Methylphenidate
15 Rivastigmine Monotherapy and Combination Therapy With Memantine in Patients With Moderately Severe Alzheimer's Disease Who Failed to Benefit From Previous Cholinesterase Inhibitor Treatment Completed NCT00234637 Phase 4 Rivastigmine, memantine
16 Hippocampus Study: Comparative Effect of Donepezil 10mg/d and Placebo on Clinical and Radiological Markers Completed NCT00403520 Phase 4 Experimental 1;Placebo Comparator
17 Vitamin B12 Supplement to Prevent Cognitive Decline Completed NCT02457507 Phase 4
18 The Efficacy of Galantamine Treatment on Attention in Patients With Alzheimer's Disease Completed NCT01054976 Phase 4 Galantamine
19 The Efficacy of a Combination Regimen in Patients With Mild to Moderate Probable Alzheimer's Disease Completed NCT01921972 Phase 4 Galantamine CR;Memantine;Placebo
20 Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease Completed NCT00933608 Phase 4 memantine;Placebo
21 Neural Correlates In Mild Alzheimer's Disease Completed NCT00477659 Phase 4 donepezil HCl (Aricept)
22 Clinical Effectiveness of 10 cm^2 Rivastigmine Patch in Patients With Alzheimer's Disease Completed NCT00561392 Phase 4 Rivastigmine 5 and 10 cm^2 patch
23 Neptune Krill Oil (NKO™) in Early Stage Alzheimer's Disease (MNEMOSYNE) Completed NCT00867828 Phase 4
24 The Dementia Study in Northern Norway Completed NCT00443014 Phase 4
25 Alzheimer's Disease Reminiscence Quality of Life Completed NCT01295957 Phase 4
26 Olfactory Deficits in MCI as Predictor of Improved Cognition on Donepezil Completed NCT01845636 Phase 4 Donepezil;Atropine
27 Do HMG CoA Reductase Inhibitors Affect Abeta Levels? Completed NCT00303277 Phase 4 simvastatin;pravastatin
28 The Effects of the Rivastigmine Patch on Parkinson's Disease With Memory and/or Thinking Problems Completed NCT00988117 Phase 4 Rivastigmine Patch 9.5 cm2
29 Effectiveness of Florbetapir (18F) PET Imaging in Changing Patient Management and the Relationship Between Scan Status and Cognitive Decline Completed NCT01703702 Phase 4 florbetapir (18F)
30 Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44 Completed NCT00948766 Phase 4 Rivastigmine 4.6 mg/24 h (5 cm^2);Rivastigmine 9.5 mg/24 h (10 cm^2);Rivastigmine 13.3 mg/24 h (15 cm^2);Placebo
31 A Study of Memantine Hydrochloride (Namenda®) for Cognitive and Behavioral Impairment in Adults With Autism Spectrum Disorders Completed NCT01333865 Phase 4 Memantine
32 A Clinical Trial to Evaluate the Safety and Efficacy of 20 ml Cerebrolysin in Patients With Vascular Dementia Completed NCT00947531 Phase 4 Cerebrolysin;0.9% Saline Solution
33 A Study of EGb 761® (Tanakan®) in Dementia of Alzheimer Type Onset in Patients Suffering From Memory Complaints Completed NCT00276510 Phase 4 EGb 761® (Tanakan®)
34 Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder Completed NCT00741598 Phase 4 Galantamine-ER;Galantamine placebo
35 Galantamine Effects in Patients With Metabolic Syndrome Completed NCT02283242 Phase 4 Galantamine;Placebo (for galantamine)
36 The Efficacy of Gliatiline® on Post-stroke Patients With Vascular Cognitive Impairment no Dementia Completed NCT01363648 Phase 4 choline alfoscerate;placebo (for choline alphoscerate)
37 The Effect of Anticholinesterase Drugs on Sleep in Alzheimer's Disease Patients Completed NCT00480870 Phase 4 donepezil;Placebo
38 Impact of Anticoagulation Therapy on the Cognitive Decline and Dementia in Patients With Non-Valvular Atrial Fibrillation Recruiting NCT03061006 Phase 4 Dabigatran Etexilate;Warfarin
39 Nuedexta in the Treatment of Pseudobulbar Affect in Patients With Alzheimer's Disease Active, not recruiting NCT01832350 Phase 4 Nuedexta (20/10)
40 A Based on PEEG and PET Study of Anxiolytic Treatment to Improve Cognitive Function in Patients With Alzheimer Disease Not yet recruiting NCT03151382 Phase 4 Tandospirone Citrate;Donepezil Hydrochloride
41 The CIRCADIAN Study: Evaluation of Modulating Effect of Galantamine on Circadian Rhythm in Patients With Mild to Moderate Alzheimer's Disease Terminated NCT01181921 Phase 4 Galantamine
42 Functional Brain Imaging of Medication Treatment Response in Mild Alzheimer's Disease Patients Terminated NCT00369603 Phase 4 Razadyne ER;Aricept
43 Optimisation of Antipsychotic Drug Use in Older People Terminated NCT01454453 Phase 4 Patients- dose titration
44 Observational Study Of Donepezil In Routine Clinical Practice Terminated NCT00843115 Phase 4
45 Memantine and Antipsychotics Use Terminated NCT00649220 Phase 4 Memantine
46 Evaluating The Impact Of Donepezil Hydrochloride (Aricept) On Behavioral And Psychological Symptoms In Patients With Severe Alzheimer's Disease Withdrawn NCT00711204 Phase 4 Donepezil Hydrochloride (Aricept)
47 A Pilot Study of Inflammatory Markers in Alzheimer's Disease Unknown status NCT00715858 Phase 3 doxycycline;rifampin;placebo
48 Donepezil Treatment of Psychotic Symptoms in Dementia Patients Unknown status NCT00190021 Phase 3 donepezil
49 Open-Label Extension Study of 23 mg Donepezil SR in Patients With Moderate to Severe Alzheimer's Disease Completed NCT00566501 Phase 3 23 mg SR in Study 326;10 mg IR in Study 326
50 VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study) Completed NCT00056225 Phase 3 Folate;Vitamin B6;Vitamin B12

Search NIH Clinical Center for Alzheimer Disease 12

Genetic Tests for Alzheimer Disease 12

Anatomical Context for Alzheimer Disease 12

MalaCards organs/tissues related to Alzheimer Disease 12:

Brain, Testes, Bone, Breast, Skin, Hypothalamus

Publications for Alzheimer Disease 12

Variations for Alzheimer Disease 12

Expression for Alzheimer Disease 12

Search GEO for disease gene expression data for Alzheimer Disease 12.

Pathways for Alzheimer Disease 12

GO Terms for Alzheimer Disease 12

Sources for Alzheimer Disease 12

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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