MCID: ALZ037
MIFTS: 45

Alzheimer Disease-2 malady

Genetic diseases, Rare diseases, Mental diseases, Neuronal diseases categories

Aliases & Classifications for Alzheimer Disease-2

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Aliases & Descriptions for Alzheimer Disease-2:

Name: Alzheimer Disease-2 46 9
Alzheimer Disease Type 2 64 42 20 22
Late Onset Familial Alzheimer Disease 42 20
Late Onset Alzheimer Disease 42 44
Alzheimer Disease 2 46 61
Senile Dementia 64 61
Alzheimer Disease Associated with Apoe E4 42
 
Late-Onset Familial Alzheimer Disease 64
Alzheimer Disease, Late Onset 61
Late-Onset Alzheimer Disease 64
Alzheimer's Disease 61
Lofad 42
Ad2 42


Classifications:



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OMIM46 104310

Summaries for Alzheimer Disease-2

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NIH Rare Diseases:42 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

MalaCards based summary: Alzheimer Disease-2, also known as alzheimer disease type 2, is related to alzheimer disease and dementia, and has symptoms including dementia, parkinsonism and neurofibrillary tangles. An important gene associated with Alzheimer Disease-2 is APOE (apolipoprotein E), and among its related pathways are Alzheimer's disease and A-beta Uptake and Degradation. The drugs galantamine and selegiline and the compounds thioflavine s and metrifonate have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotype other.

Description from OMIM:46 104310

Related Diseases for Alzheimer Disease-2

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Diseases in the Alzheimer Disease family:

Alzheimer Disease 17 Alzheimer Disease 12
Alzheimer Disease 18 Alzheimer Disease 16
Alzheimer Disease-4 Alzheimer Disease, Type 3
alzheimer disease-2 Alzheimer Disease 19, Late Onset
Alzheimer Disease Type 1 Alzheimer Disease Risk Factor
Early-Onset Autosomal Dominant Alzheimer Disease

Diseases related to Alzheimer Disease-2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer disease31.7APOE, APP
2dementia30.7APOE, APP
3dementia, lewy body30.5APOE, APP
4hereditary cerebral amyloid angiopathy10.4APP
5inclusion body myositis10.4APP
6neuronitis10.4
7alzheimer disease 19, late onset10.3
8hyperlipidemia type 310.3
9hydrocephalus10.3
10communicating hydrocephalus10.3
11cerebral atrophy10.3
12parkinson disease, late-onset10.2APOE
13coronary artery disease10.2
14microcephaly10.2
15cerebritis10.2
16artery disease10.2
17posterior cortical atrophy10.2
18alzheimer disease mitochondrial10.2
19amyotrophic lateral sclerosis 110.2APP
20schizophrenia10.1
21hematologic cancer10.1
22capgras syndrome10.1
23arteriosclerosis10.1
24cerebral arteriosclerosis10.1
25blindness10.1
26binswanger's disease10.1APOE, APP
27hemorrhage, intracerebral10.1APOE, APP
28cerebral amyloid angiopathy10.1APP, APOE
29supranuclear palsy, progressive10.1APOE, APP
30vascular dementia10.1APOE, APP
31creutzfeldt-jakob disease10.1APOE, APP
32pick disease10.1APP, APOE
33cerebrovascular disease10.1APOE, APP
34dementia, frontotemporal10.1APP, APOE
35amyloidosis10.0APOE, APP
36prion disease10.0APOE, APP
37down syndrome10.0APOE, APP
38diabetes mellitus, insulin-dependent9.8MT-ND1, APOE
39diabetes mellitus, noninsulin-dependent9.7APOE, MT-ND1

Graphical network of the top 20 diseases related to Alzheimer Disease-2:



Diseases related to alzheimer disease-2

Symptoms for Alzheimer Disease-2

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Symptoms by clinical synopsis from OMIM:

104310

Clinical features from OMIM:

104310

HPO human phenotypes related to Alzheimer Disease-2:

(show all 6)
id Description Frequency HPO Source Accession
1 dementia HP:0000726
2 parkinsonism HP:0001300
3 neurofibrillary tangles HP:0002185
4 long-tract signs HP:0002423
5 alzheimer disease HP:0002511
6 late onset HP:0003584

Drugs & Therapeutics for Alzheimer Disease-2

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Genetic Tests for Alzheimer Disease-2

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Genetic tests related to Alzheimer Disease-2:

id Genetic test Affiliating Genes
1 Late-Onset Familial Alzheimer Disease20
2 Alzheimer Disease Type 220 APOE
3 Alzheimer Disease, Type 222

Anatomical Context for Alzheimer Disease-2

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MalaCards organs/tissues related to Alzheimer Disease-2:

31
Brain

Animal Models for Alzheimer Disease-2 or affiliated genes

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MGI Mouse Phenotypes related to Alzheimer Disease-2:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.3APP, APOE

Publications for Alzheimer Disease-2

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Variations for Alzheimer Disease-2

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Clinvar genetic disease variations for Alzheimer Disease-2:

5
id Gene Variation Type Significance SNP ID Assembly Location
1APPNM_000484.3(APP): c.2149G> A (p.Val717Ile)single nucleotide variantPathogenicrs63750264GRCh37Chr 21, 27264096: 27264096
2APPNM_000484.3(APP): c.2075C> G (p.Ala692Gly)single nucleotide variantPathogenicrs63750671GRCh37Chr 21, 27264170: 27264170
3APPNM_000484.3(APP): c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu)indelPathogenicrs281865161GRCh37Chr 21, 27269938: 27269939
4APPNM_000484.3(APP): c.2078A> G (p.Glu693Gly)single nucleotide variantPathogenicrs63751039GRCh37Chr 21, 27264167: 27264167
5APPNM_000484.3(APP): c.2018C> T (p.Ala673Val)single nucleotide variantPathogenicrs193922916GRCh37Chr 21, 27269931: 27269931
6HFENM_000410.3(HFE): c.845G> A (p.Cys282Tyr)single nucleotide variantPathogenic, confers sensitivity, risk factorrs1800562GRCh37Chr 6, 26093141: 26093141
7MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Alzheimer Disease-2

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Search GEO for disease gene expression data for Alzheimer Disease-2.

Pathways for genes affiliated with Alzheimer Disease-2

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Pathways related to Alzheimer Disease-2 according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Alzheimers Disease36
9.3APP, APOE
29.3APP, APOE
39.3APP, APOE
49.3APP, APOE
59.3APOE, APP

Compounds for genes affiliated with Alzheimer Disease-2

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Compounds related to Alzheimer Disease-2 according to GeneCards Suite gene sharing:

(show all 28)
idCompoundScoreTop Affiliating Genes
1thioflavine s449.7APOE, APP
2metrifonate449.7APOE, APP
324s-hydroxy-cholesterol449.7APOE, APP
4thioflavin t449.7APP, APOE
5tacrine44 1110.7APOE, APP
6donepezil44 50 24 1112.7APOE, APP
7galantamine44 50 1111.7APP, APOE
8formate449.7APP, APOE
9ibuprofen44 28 50 24 1113.6APP, APOE
104-hydroxynonenal44 2410.6APOE, APP
11chloroquine44 1 50 28 1113.6APP, APOE
12lactacystin449.6APOE, APP
13lovastatin44 50 60 28 1113.6APP, APOE
14sodium dodecylsulfate449.6APP, APOE
15simvastatin44 50 60 28 24 1114.6APP, APOE
16folate449.5APP, APOE
17nicotine44 28 50 1112.5APP, APOE
18isoflurane50 44 1111.5APP, MT-ND1
19vitamin a44 24 1111.4APOE, APP
20aspirin44 50 28 2412.4APOE, APP
21FAD249.4MT-ND1, APP
22nmda44 2810.3APOE, APP
23cyclosporin a44 28 6011.3APOE, APP
24acetylcholine44 50 28 24 1113.2APOE, APP
25actinomycin d449.0APOE, APP
26valine448.9APOE, MT-ND1, APP
27alanine448.8MT-ND1, APP, APOE
28serine448.7MT-ND1, APOE, APP

GO Terms for genes affiliated with Alzheimer Disease-2

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Biological processes related to Alzheimer Disease-2 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cholesterol metabolic processGO:00082039.3APP, APOE

Molecular functions related to Alzheimer Disease-2 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.3APP, APOE

Sources for Alzheimer Disease-2

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet