AD1
MCID: ALZ002
MIFTS: 32

Alzheimer Disease Type 1 (AD1) malady

Ear diseases, Genetic diseases categories

Summaries for Alzheimer Disease Type 1

About this section
Sources:
42NIH Rare Diseases, 19GeneReviews, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

MalaCards: Alzheimer Disease Type 1, also known as early-onset familial alzheimer disease, is related to frontotemporal dementia and dementia. An important gene associated with Alzheimer Disease Type 1 is PSEN2 (presenilin 2 (Alzheimer disease 4)), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Disease. The compounds ab-42 and lactacystin have been mentioned in the context of this disorder. Affiliated tissues include brain.

GeneReviews summary for alzheimer-early

Aliases & Classifications for Alzheimer Disease Type 1

About this section
Sources:
63Wikipedia, 42NIH Rare Diseases, 60UMLS, 19GeneReviews, 20GeneTests, 22GTR
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Ear diseases


Aliases & Descriptions:

alzheimer disease type 1 63 42 60
early-onset familial alzheimer disease 63 19 20
alzheimer disease 1 42 20 22
early-onset familial form of alzheimer disease 42
eofad 19
ad1 42


Related Diseases for Alzheimer Disease Type 1

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of diseases related to Alzheimer Disease Type 1:



Diseases related to alzheimer disease type 1

Clinical Features for Alzheimer Disease Type 1

About this section

Drugs & Therapeutics for Alzheimer Disease Type 1

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Alzheimer Disease Type 1

Drug clinical trials:

Search ClinicalTrials for Alzheimer Disease Type 1

Search NIH Clinical Center for Alzheimer Disease Type 1

Search CenterWatch for Alzheimer Disease Type 1

Genetic Tests for Alzheimer Disease Type 1

About this section
Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Alzheimer Disease Type 1:

id Genetic test Affiliating Genes
1 Early-Onset Familial Alzheimer Disease20 PSEN2
2 Alzheimer Disease Type 120 APP
3 Alzheimer Disease, Type 122

Anatomical Context for Alzheimer Disease Type 1

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Alzheimer Disease Type 1:

32
Brain

Animal Models for Alzheimer Disease Type 1 or affiliated genes

About this section

Publications for Alzheimer Disease Type 1

About this section
Sources:
50PubMed
See all sources

Articles related to Alzheimer Disease Type 1:

idTitleAuthorsYear
1
Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. (16574645)
2006
2
Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease. (9576554)
1998

Genetic Variations for Alzheimer Disease Type 1

About this section

Expression for genes affiliated with Alzheimer Disease Type 1

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alzheimer Disease Type 1

Search GEO for disease gene expression data for Alzheimer Disease Type 1.

Pathways for genes affiliated with Alzheimer Disease Type 1

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
See all sources

Compounds for genes affiliated with Alzheimer Disease Type 1

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Alzheimer Disease Type 1 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ab-42449.4PSEN2, APP
2lactacystin449.3PSEN2, APP
3choline44 11 2411.3APP, PSEN2
4curcumin449.3PSEN2, APP
5valine449.2PSEN2, APP
6paclitaxel44 49 1111.2APP, PSEN2
7actinomycin d449.1PSEN2, APP
8cholesterol44 28 11 2412.1PSEN2, APP
9aspartate449.0PSEN2, APP
10h2o2448.8PSEN2, APP

GO Terms for genes affiliated with Alzheimer Disease Type 1

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Alzheimer Disease Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:0352539.3PSEN2, APP
2dendritic shaftGO:0431989.2PSEN2, APP
3neuromuscular junctionGO:0315949.2PSEN2, APP
4axonGO:0304249.1APP, PSEN2
5Golgi apparatusGO:0057949.1PSEN2, APP
6cell surfaceGO:0099869.0PSEN2, APP
7perinuclear region of cytoplasmGO:0484718.8PSEN2, APP

Biological processes related to Alzheimer Disease Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epidermal growth factor-activated receptor activityGO:0071769.1PSEN2, APP
2Notch signaling pathwayGO:0072199.1PSEN2, APP
3regulation of protein bindingGO:0433939.0PSEN2, APP
4forebrain developmentGO:0309008.8PSEN2, APP

Products for genes affiliated with Alzheimer Disease Type 1

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alzheimer Disease Type 1

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet