AD1
MCID: ALZ002
MIFTS: 23

Alzheimer Disease Type 1 (AD1) malady

Genetic diseases, Rare diseases, Mental diseases, Neuronal diseases categories

Summaries for Alzheimer Disease Type 1

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Sources:
44NIH Rare Diseases, 20GeneReviews, 34MalaCards
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NIH Rare Diseases:44 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

MalaCards: Alzheimer Disease Type 1, also known as early-onset familial alzheimer disease, is related to hyperlipidemia type 3 and frontotemporal dementia. An important gene associated with Alzheimer Disease Type 1 is PSEN2 (presenilin 2). Affiliated tissues include brain.

GeneReviews summary for alzheimer-early

Aliases & Classifications for Alzheimer Disease Type 1

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Sources:
66Wikipedia, 44NIH Rare Diseases, 63UMLS, 20GeneReviews, 21GeneTests, 23GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

alzheimer disease type 1 66 44 63
early-onset familial alzheimer disease 66 20 21
alzheimer disease 1 44 21 23
early-onset familial form of alzheimer disease 44
eofad 20
ad1 44


Related Diseases for Alzheimer Disease Type 1

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18GeneCards, 19GeneDecks
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Graphical network of diseases related to Alzheimer Disease Type 1:



Diseases related to alzheimer disease type 1

Symptoms for Alzheimer Disease Type 1

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Drugs & Therapeutics for Alzheimer Disease Type 1

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Alzheimer Disease Type 1

Drug clinical trials:

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Search NIH Clinical Center for Alzheimer Disease Type 1

Search CenterWatch for Alzheimer Disease Type 1

Genetic Tests for Alzheimer Disease Type 1

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21GeneTests, 23GTR
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Genetic tests related to Alzheimer Disease Type 1:

id Genetic test Affiliating Genes
1 Early-Onset Familial Alzheimer Disease21 PSEN2
2 Alzheimer Disease Type 121 APP
3 Alzheimer Disease, Type 123

Anatomical Context for Alzheimer Disease Type 1

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34MalaCards
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MalaCards organs/tissues related to Alzheimer Disease Type 1:

34
Brain

Animal Models for Alzheimer Disease Type 1 or affiliated genes

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Publications for Alzheimer Disease Type 1

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Variations for Alzheimer Disease Type 1

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Sources:
1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Alzheimer Disease Type 1:

1
id Gene Name Type Significance SNP ID Assembly Location
1APPNM_000484.3(APP): c.2149G> A (p.Val717Ile)single nucleotide variantPathogenicrs63750264GRCh37Chr 21, 27264096: 27264096
2APPNM_000484.3(APP): c.2075C> G (p.Ala692Gly)single nucleotide variantPathogenicrs63750671GRCh37Chr 21, 27264170: 27264170
3APPNM_000484.3(APP): c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu)indelPathogenicrs281865161GRCh37Chr 21, 27269938: 27269939
4APPNM_000484.3(APP): c.2078A> G (p.Glu693Gly)single nucleotide variantPathogenicrs63751039GRCh37Chr 21, 27264167: 27264167

Expression for genes affiliated with Alzheimer Disease Type 1

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alzheimer Disease Type 1

Search GEO for disease gene expression data for Alzheimer Disease Type 1.

Pathways for genes affiliated with Alzheimer Disease Type 1

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Compounds for genes affiliated with Alzheimer Disease Type 1

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GO Terms for genes affiliated with Alzheimer Disease Type 1

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Products for genes affiliated with Alzheimer Disease Type 1

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alzheimer Disease Type 1

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet