AD1
MCID: ALZ002
MIFTS: 29

Alzheimer Disease Type 1 (AD1) malady

Ear, Genetic categories

Summaries for Alzheimer Disease Type 1

Sources:
43NIH Rare Diseases, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

MalaCards: Alzheimer Disease Type 1, also known as early-onset familial alzheimer disease, is related to frontotemporal dementia and alzheimer disease type 2. An important gene associated with Alzheimer Disease Type 1 is PSEN2 (presenilin 2 (Alzheimer disease 4)), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Disease. The compounds ab-42 and lactacystin have been mentioned in the context of this disorder. Affiliated tissues include brain.

GeneReviews summary for alzheimer-early

Aliases & Classifications for Alzheimer Disease Type 1

Sources:
64Wikipedia, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Ear


Aliases & Descriptions:

alzheimer disease type 1 64 43 61
early-onset familial alzheimer disease 64 19 20
alzheimer disease 1 43 20 22
early-onset familial form of alzheimer disease 43
eofad 19
ad1 43


Related Diseases for Alzheimer Disease Type 1

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Alzheimer Disease Type 1:



Diseases related to alzheimer disease type 1

Clinical Features for Alzheimer Disease Type 1

Drugs & Therapeutics for Alzheimer Disease Type 1

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Alzheimer Disease Type 1

Sources:
20GeneTests, 22GTR
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Genetic tests related to Alzheimer Disease Type 1:

id Genetic test Affiliating Genes
1 Early-onset Familial Alzheimer Disease20 PSEN2
2 Alzheimer Disease Type 120 APP
3 Alzheimer Disease, Type 122

Anatomical Context for Alzheimer Disease Type 1

Sources:
33MalaCards
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MalaCards organs/tissues related to Alzheimer Disease Type 1:

33
Brain

Animal Models for Alzheimer Disease Type 1 or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Alzheimer Disease Type 1

Sources:
51PubMed
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Articles related to Alzheimer Disease Type 1:

idTitleAuthorsYear
1
The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1. (23867133)
2013
2
Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis. (19756307)
2009
3
Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2. (12898287)
2003
4
Role of type 10 17beta-hydroxysteroid dehydrogenase in the pathogenesis of Alzheimer's disease. (11403151)
2001

Genetic Variations for Alzheimer Disease Type 1

Expression for genes affiliated with Alzheimer Disease Type 1

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alzheimer Disease Type 1

Search GEO for disease gene expression data for Alzheimer Disease Type 1.

Pathways for genes affiliated with Alzheimer Disease Type 1

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 53R&D Systems
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Compounds for genes affiliated with Alzheimer Disease Type 1

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
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Compounds related to Alzheimer Disease Type 1 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ab-42459.4PSEN2, APP
2lactacystin459.3PSEN2, APP
3choline45 11 2411.3APP, PSEN2
4curcumin459.3PSEN2, APP
5valine459.2PSEN2, APP
6paclitaxel45 50 1111.2APP, PSEN2
7actinomycin d459.1PSEN2, APP
8cholesterol45 29 11 2412.1PSEN2, APP
9aspartate459.0PSEN2, APP
10h2o2458.8PSEN2, APP

GO Terms for genes affiliated with Alzheimer Disease Type 1

Sources:
16Gene Ontology
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Cellular components related to Alzheimer Disease Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:0352539.3PSEN2, APP
2dendritic shaftGO:0431989.2PSEN2, APP
3neuromuscular junctionGO:0315949.2PSEN2, APP
4axonGO:0304249.1APP, PSEN2
5Golgi apparatusGO:0057949.1PSEN2, APP
6cell surfaceGO:0099869.0PSEN2, APP
7perinuclear region of cytoplasmGO:0484718.8PSEN2, APP

Biological processes related to Alzheimer Disease Type 1 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of epidermal growth factor-activated receptor activityGO:0071769.1PSEN2, APP
2Notch signaling pathwayGO:0072199.1PSEN2, APP
3regulation of protein bindingGO:0433939.0PSEN2, APP
4forebrain developmentGO:0309008.8PSEN2, APP

Products for genes affiliated with Alzheimer Disease Type 1

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alzheimer Disease Type 1

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet