AD
MCID: ALZ001
MIFTS: 93

Alzheimer's Disease (AD) malady

Neuronal, Genetic categories

Summaries for Alzheimer's Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 44NINDS, 21Genetics Home Reference, 46Novus Biologicals, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Alzheimer's disease (ad) is the most common form of dementia among older people. dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. ad begins slowly. it first involves the parts of the brain that control thought, memory and language. people with ad may have trouble remembering things that happened recently or names of people they know. a related problem, mild cognitive impairment (mci), causes more memory problems than normal for people of the same age. many, but not all, people with mci will develop ad. in ad, over time, symptoms get worse. people may not recognize family members or have trouble speaking, reading or writing. they may forget how to brush their teeth or comb their hair. later on, they may become anxious or aggressive, or wander away from home. eventually, they need total care. this can cause great stress for family members who must care for them. ad usually begins after age 60. the risk goes up as you get older. your risk is also higher if a family member has had the disease. no treatment can stop the disease. however, some drugs may help keep symptoms from getting worse for a limited time. nih: national institute on aging

MalaCards: Alzheimer's Disease, also known as alzheimer disease, is related to vascular dementia and alzheimer disease type 1. An important gene associated with Alzheimer's Disease is A2M (alpha-2-macroglobulin), and among its related pathways are Neuroscience and Signaling by GPCR. The drugs galantamine and selegiline and the compounds cholesterol and lipid have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are mortality/aging and behavior/neurological.

Disease Ontology:8 A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. it is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

NIH Rare Diseases:43 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

CDC:3 Alzheimer’s disease is the most common form of dementia among older adults. Alzheimer’s disease involves parts of the brain that control thought, memory, and language and can seriously affect a person’s ability to carry out daily activities. Although scientists are learning more every day, right now, they still do not know what causes Alzheimer’s disease.

NINDS:44 Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.

Genetics Home Reference:21 Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.

Novus Biologicals:46 Alzheimer's Disease (AD) is the most common form of dementia that affects 5.3 million Americans. AD causes the damage and destruction of nerves in the brain. Hallmark abnormalities include deposits of beta-amyloid (plaques) and twisted strands of tau (tangles). Beta-amyloid peptide, a protein derived from amyloid precursor protein (APP), aggregates into a beta-pleated sheet configuration which is neurotoxic and forms the core of neuritic plaques. These abnormalities disrupt cellular communication, cause damage via oxidative metabolism, initiate abnormal accumulation of cytoskeletal proteins and result in cell death. Genes identified as causing susceptibility to Alzheimer's disease do not singly cause the disease state, but when combined with other epigenetic and environmental factors can lead to the condition.

Wikipedia:64 Alzheimer\'s disease (AD), also known in medical literature as Alzheimer disease, is the most common... more...

Description from OMIM:47 104310,606889,607822,104300

GeneReviews summary for alzheimer

Aliases & Classifications for Alzheimer's Disease

Sources:
19GeneReviews, 61UMLS, 8Disease Ontology, 64Wikipedia, 21Genetics Home Reference, 44NINDS, 34MedlinePlus, 31LifeMap Discovery™, 43NIH Rare Diseases, 20GeneTests, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Neuronal


Aliases & Descriptions:

alzheimer's disease 8 64 21 44 34 31 61
alzheimer disease 19 43 20 22 21 47
familial alzheimer disease 64 43 21
ad 8 64 21
primary senile degenerative dementia 64 21
presenile and senile dementia 64 21
alzheimers disease 10 45
alstrom syndrome 19 61
sdat 64 21
dementia in alzheimer's disease, unspecified 8
dementia of the alzheimer's type 8
dat - dementia alzheimer's type 64
dementia in alzheimer's disease 8
alzheimer disease, familial 61
alzheimer disease familial 43
alzheimer-type dementia 21
alzheimer sclerosis 21
alzheimers dementia 8
alzheimer syndrome 21
alzheimer dementia 21
fad 43
dat 21


Related Diseases for Alzheimer's Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Alzheimer's Disease family:

alzheimer disease type 1 alzheimer disease type 2
alzheimer disease type 3 alzheimer disease type 4
alzheimer's disease without neurofibrillary tangles alzheimer disease type 5
alzheimer disease-13 alzheimer disease-14
alzheimer disease-15 alzheimer disease 17
alzheimer disease-10 alzheimer disease 12
alzheimer disease-11 alzheimer disease-7
alzheimer disease 6 alzheimer disease, type 3, with spastic paraparesis and unusual plaques
alzheimer disease, type 3, with spastic paraparesis and apraxia alzheimer disease 18
alzheimer disease 9, late onset alzheimer disease 8
alzheimer disease 1, familial alzheimer disease 16

Diseases related to Alzheimer's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 443)
idRelated DiseaseScoreTop Affiliating Genes
1vascular dementia30.6APOE
2alzheimer disease type 130.5PSEN1, APP, PSEN2
3amyloidosis30.4APBB1, APOE, APP, PSEN1, PSEN2
4progressive supranuclear palsy30.3APOE
5hypercholesterolemia30.3ACE, APOE
6amyotrophic lateral sclerosis30.2APP, CASP3, PSEN1, CHAT
7pick's disease30.2PSEN1, CHAT, APP, APOE
8vascular disease30.2CASP3
9hepatitis c30.2HFE
10acute myocardial infarction30.1ACE
11frontotemporal dementia30.1APP, APOE, PSEN1, PSEN2
12brain disease30.1CHAT, APP, PSEN1
13alzheimer disease type 230.0PSEN1, APOE, APP, GSK3B, PSEN2
14memory impairment30.0APP, APOE, CDK5R1, CHAT, PSEN1
15insulin resistance30.0HFE, ACE, GSK3B
16coronary heart disease30.0HFE, APOE, ACE
17atherosclerosis30.0MPO, ACE, APOE
18colorectal cancer30.0CASP3, CASP2
19cadasil29.9CHAT, APOE, ACE, PSEN1
20down syndrome29.9APP, APOE, PSEN1, PSEN2, CHAT
21parkinson's disease29.7CHAT, CDK5R1, CASP3, APP, APOE, PSEN1
22cerebral amyloid angiopathy29.7APOE, PSEN1, APP
23hemochromatosis29.6HFE, HLA-H
24hidradenitis suppurativa29.6NCSTN, PSENEN
25inclusion body myositis29.6APP
26acute pancreatitis29.6MPO
27lewy body dementia29.6APOE
28cystic fibrosis29.6MPO
29alstrom syndrome10.8
30hyperlipidemia type 310.8
31alstr�m syndrome10.6
32alzheimer disease mitochondrial10.5
33alström syndrome10.4
34fetal akinesia deformation sequence10.4
35pica disease10.3
36normal pressure hydrocephalus10.3
37al amyloidosis10.3
38apraxia10.2
39vascular cancer10.2
40amyloidosis cerebral10.2
41alzheimer disease-1410.2
42alzheimer disease 610.2
43n syndrome10.2
44tardive dyskinesia10.2
45atopic dermatitis10.2
46lateral sclerosis10.2
47hereditary amyloidosis10.2
48primary progressive aphasia10.2
49corticobasal degeneration10.2
50semantic dementia10.2

Graphical network of the top 20 diseases related to Alzheimer's Disease:



Diseases related to alzheimer's disease

Clinical Features for Alzheimer's Disease

Sources:
47OMIM
See all sources

Clinical features from OMIM:

104310,606889,607822,104300

Drugs & Therapeutics for Alzheimer's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alzheimer's Disease

Drug clinical trials:

Search ClinicalTrials for Alzheimer's Disease

Search NIH Clinical Center for Alzheimer's Disease

Search CenterWatch for Alzheimer's Disease

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Alzheimer's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alzheimer's Disease:
NEUROSTEM
Embryonic/Adult Cultured Cells Related to Alzheimer's Disease:
Umbilical cord blood-derived mesenchymal stem/progenitor cells , PMIDs: 23293711, 22015609

Genetic Tests for Alzheimer's Disease

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Alzheimer's Disease:

id Genetic test Affiliating Genes
1 Alzheimer Disease20
2 Alzheimer's Disease22

Anatomical Context for Alzheimer's Disease

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Alzheimer's Disease:

33
Skin, Liver, Spinal cord, Brain, Whole blood, Cortex, Cerebellum, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Thyroid, Breast, Placenta, Prostate, Monocytes, Dentritic cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Prefrontal cortex, Cingulate cortex, Parietal lobe, Temporal lobe, Occipital lobe, Olfactory bulb, Thalamus, Hypothalamus, Subthalamic nucleus, Caudate nucleus, Amygdala, Pons, Fetal liver, Fetal thyroid, Adrenal cortex, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alzheimer's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
3 BrainHippocampus  Affected by disease

Animal Models for Alzheimer's Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Alzheimer's Disease

Sources:
51PubMed
See all sources

Articles related to Alzheimer's Disease:

(show top 50)    (show all 3475)
idTitleAuthorsYear
1
Systematic review of the effects of exercise on activities of daily living in people with Alzheimer's disease. (24367955)
2014
2
Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes. (22580620)
2012
3
SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population. (22353753)
2012
4
Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. (22272811)
2012
5
DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease. (22678883)
2012
6
Breakpoint sequence analysis of an AI^PP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy. (22008262)
2012
7
Association studies of 19 candidate SNPs with sporadic Alzheimer's disease in the North Chinese Han population. (22167654)
2012
8
Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. (22179327)
2012
9
Ameliorative effects of telmisartan on the inflammatory response and impaired spatial memory in a rat model of Alzheimer's disease incorporating additional cerebrovascular disease factors. (23207766)
2012
10
The I^-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease. (21181298)
2011
11
NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease. (20658994)
2010
12
Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation. (20427671)
2010
13
Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid clearance. (21504118)
2010
14
The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease. (19589055)
2009
15
Effect of a short- and long-term treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer's disease. (18996078)
2009
16
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. (18802446)
2008
17
Practical issues in stem cell therapy for Alzheimer's disease. (17908039)
2007
18
Structure of Alzheimer's disease amyloid precursor protein copper- binding domain at atomic resolution. (17909280)
2007
19
The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. (17498878)
2007
20
Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling. (16257224)
2006
21
Prospective memory and apolipoprotein E in healthy aging and early stage Alzheimer's disease. (17100508)
2006
22
Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes. (15949941)
2005
23
The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations. (16127101)
2005
24
Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. (16300681)
2005
25
Alzheimer's disease: role of size and location of white matter changes in determining cognitive deficits. (16192726)
2005
26
Novel insertional presenilin 1 mutation causing Alzheimer disease with spastic paraparesis. (15159497)
2004
27
Prominent behavioural and psychiatric symptoms in early-onset Alzheimer's disease in a sib pair with the presenilin-1 gene R269G mutation. (15205973)
2004
28
An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer's disease. (15211644)
2004
29
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. (15075440)
2004
30
DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. (12890786)
2003
31
Nerve growth factor: structure, function and therapeutic implications for Alzheimer's disease. (14529363)
2003
32
Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology. (12566568)
2003
33
Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. (14676050)
2003
34
Association analysis for the genetic variants of the NMDA receptor subunit 2b and Alzheimer's disease. (11844890)
2002
35
Asymmetric myoclonic parietal syndrome in a patient with Alzheimer's disease mimicking corticobasal degeneration. (11940412)
2002
36
Cathepsin D polymorphism in Italian sporadic and familial Alzheimer's disease. (12147324)
2002
37
Factors predicting success in picture naming in Alzheimer's disease and primary progressive aphasia. (11527323)
2001
38
It all sticks together--the APP-related family of proteins and Alzheimer's disease. (10578233)
1999
39
Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. (9916793)
1999
40
Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent. (10528114)
1999
41
Identification of septins in neurofibrillary tangles in Alzheimer's disease. (9811347)
1998
42
Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. (9665462)
1998
43
Vasopressin and bradykinin regulate secretory processing of the amyloid protein precursor of Alzheimer's disease. (9566621)
1998
44
Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein. (9055862)
1997
45
Alzheimer's disease neurofibrillary tangles contain mitosis-specific phosphoepitopes. (8931473)
1996
46
The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial. The Donepezil Study Group. (8915035)
1996
47
Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau. (7830071)
1995
48
Differential incorporation of processes derived from different classes of neurons into senile plaques in Alzheimer's disease. (8256587)
1993
49
Mutation of the gene for the human lysosomal serine protease cathepsin G is not the cause of aberrant APP processing in familial Alzheimer disease. (8515885)
1993
50
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. (3257719)
1988

Genetic Variations for Alzheimer's Disease

Expression for genes affiliated with Alzheimer's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alzheimer's Disease

Search GEO for disease gene expression data for Alzheimer's Disease.

Pathways for genes affiliated with Alzheimer's Disease

Sources:
4Cell Signaling Technology, 54Reactome, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems, 12EMD Millipore, 56SinoBiological, 60Tocris Bioscience
See all sources

Pathways related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.8GSK3B, APP, APOE, APBA2, APBB1, PSEN1
2
Hide members
12.3CASP3, CASP2, APP, APOE, PSENEN, PSEN2
3
Hide members
12.3APP, APBB1, PSEN1, PSENEN, PSEN2, NCSTN
412.1APP, APOE, PSEN1, PSEN2, A2M, CDK5R1
512.1CASP3, CASP2, APP, PSEN1, PSEN2, NCSTN
611.9APP, PSEN1, PSENEN, PSEN2, NCSTN, ACE
7
Hide members
11.9APP, PSEN1, PSENEN, PSEN2, NCSTN, GSK3B
811.9GSK3B, NCSTN, PSEN2, PSENEN, APOE, APP
9
Hide members
11.9GSK3B, NCSTN, PSEN2, PSEN1, CASP3, COL25A1
1011.6PSEN1, PSENEN, PSEN2, NCSTN, GSK3B
1111.6GSK3B, CDK5R1, APBB1, APOE, APP
1211.6NCSTN, PSENEN, PSEN1, APP, CASP3
13
Hide members
11.6CASP3, PSEN1, PSEN2, CDK5R1, GSK3B
14
Hide members
11.6NCSTN, PSEN2, PSENEN, CASP2, CASP3
15
Hide members
11.6CASP3, CASP2, PSENEN, PSEN2, NCSTN
1611.4APP, APOE, A2M, ACE
1711.4NCSTN, PSEN2, PSENEN, PSEN1
1811.4PSEN1, PSENEN, PSEN2, NCSTN
19
Hide members
11.4PSEN1, PSENEN, PSEN2, NCSTN
2011.4GSK3B, NCSTN, PSENEN, PSEN1
21
Hide members
11.4PSENEN, PSEN2, NCSTN, GSK3B
22
Hide members
11.4CASP3, CASP2, APP, GSK3B
2311.2PSEN1, PSENEN, PSEN2
2411.2NCSTN, PSENEN, PSEN1
25
Hide members
11.2NCSTN, PSEN2, PSENEN
26
Hide members
11.2NCSTN, PSEN2, PSENEN
27
Hide members
11.2PSENEN, PSEN2, NCSTN
28
Hide members
11.2PSENEN, PSEN2, NCSTN
29
Apoptosis and survival Caspase cascade
Hide members
11.2APP, CASP2, CASP3
3011.2CASP3, CDK5R1, GSK3B
31
Hide members
10.9PSENEN, NCSTN
3210.9CASP2, CASP3

Compounds for genes affiliated with Alzheimer's Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1cholesterol45 29 11 2416.2A2M, NCSTN, CASP2, APP, PSEN1, PSENEN
2lipid4513.2APOE, CASP2, APP, PSEN1, PSENEN, NCSTN
3serine4513.2APOE, PSEN2, A2M, PSEN1, APP, CASP2
4retinoic acid45 2413.8CASP2, CASP3, APP, PSEN1, PSEN2, MPO
5cysteine4512.7HFE, CASP3, CASP2, APP, APOE, PSEN1
64-hydroxynonenal45 2413.6APP, PSEN1, MPO, CHAT, CASP3, CASP2
7lactacystin4512.3PSENEN, PSEN2, APOE, PSEN1, APP, CASP3
8potassium45 11 2414.3CASP2, GSK3B, CHAT, PSEN2, PSEN1, ACE
9aspartate4512.3PSEN2, PSEN1, CHAT, APOE, HFE, APP
10testosterone45 60 11 2415.3CASP2, APP, APOE, CHAT, GSK3B, HFE
11oligonucleotide4512.2CDK5R1, CHAT, PSEN2, HFE, CASP2, PSEN1
12nitric oxide45 11 2414.2CASP2, MPO, PSEN1, CHAT, ACE, PSEN2
13alanine4512.1GSK3B, PSEN1, CHAT, HFE, APOE, APP
14valine4512.1MPO, PSEN1, APOE, APP, PSEN2
15butyrate4512.0MPO, CASP3, CASP2, CHAT, APP
16acetylcholine45 50 29 11 2416.0APOE, APP, MPO, CHAT, ACE
17glycogen45 2413.0CDK5R1, CHAT, GSK3B, PSEN1, APBB1
18paraffin4512.0CASP2, APOE, PSEN2, MPO, CHAT
19lactate4511.9BLMH, MPO, PSEN2, CHAT, CASP3
20glutamate4511.9PSEN2, PSEN1, CHAT, APP, CDK5R1
21h2o24511.8PSEN2, PSEN1, MPO, CASP2
22choline45 11 2413.8APP, PSEN1, PSEN2, CHAT
23sterol4511.8CASP2, APOE, PSENEN, PSEN1
24dapt6011.6PSEN2, PSEN1, PSENEN
25l-685,4586011.6PSEN2, PSENEN, PSEN1
26jlk 66011.6PSENEN, PSEN2, PSEN1
27begacestat6011.6PSENEN, PSEN2, PSEN1
28mrk 5606011.6PSEN2, PSENEN, PSEN1
29donepezil45 11 2413.6APOE, APP, CHAT
306-hydroxydopamine4511.5CHAT, APP, CASP3
31kininogen4511.4APP, ACE, MPO
32vitamin b124511.4MPO, APOE, PSEN1
33malondialdehyde4511.4PSEN1, CHAT, MPO
34ab-424511.3APP, PSEN2
35s-1824511.3PSEN2, PSEN1
36daunorubicin45 50 1113.3MPO, CASP3, CASP2
37Indirubin-3'-Monoxime1111.3CDK5R1, GSK3B
38thioflavine s4511.3APP, APOE
39peroxynitrite4511.3CASP2, PSEN1, MPO
40huperzine a4511.3APP, CHAT
41Human Serum Albumin1111.3APOE, MPO
42dihydralazine4511.3MPO, ACE
43metrifonate4511.3APOE, APP
4424s-hydroxy-cholesterol4511.2APP, APOE
45polyadenosine diphosphate ribose4511.1CASP3, CASP2
46ascorbic acid45 2412.1CASP2, APOE, HFE, MPO
47propentofylline4511.0APP, CHAT
48physostigmine45 1111.9APP, CHAT
49bleomycin45 1111.9BLMH, APOE
50cycloheximide4510.8PSEN1, PSEN2

GO Terms for genes affiliated with Alzheimer's Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588613.7APBA2, APOE, APP, CASP3, COL25A1, APBB1
2cytosolGO:00582912.5CASP3, CASP2, APP, PSEN2, A2M, CHAT
3integral to plasma membraneGO:00588712.4COL25A1, APP, PSEN1, PSENEN, PSEN2, HLA-H
4neuronal cell bodyGO:04302512.1APOE, PSEN1, PSEN2, CHAT, CDK5R1, GSK3B
5perinuclear region of cytoplasmGO:04847111.9APP, PSEN1, PSEN2, HFE, CDK5R1, GSK3B
6growth coneGO:03042611.9GSK3B, CDK5R1, PSEN2, PSEN1, APBB1
7Golgi apparatusGO:00579411.9APP, APOE, PSEN1, PSENEN, PSEN2, NCSTN
8axonGO:03042411.8APP, PSEN1, PSEN2, CHAT, CDK5R1
9dendritic shaftGO:04319811.7APP, PSEN1, PSEN2, GSK3B
10neuromuscular junctionGO:03159411.6APP, PSEN1, PSEN2, CDK5R1
11ciliary rootletGO:03525311.4PSEN2, PSEN1, APP
12MHC class I protein complexGO:04261210.9HFE, HLA-H
13dendritic spineGO:04319710.9GSK3B, CDK5R1, APP

Biological processes related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of apoptotic processGO:04306512.5CASP3, CASP2, APBB1, PSEN1, PSENEN, PSEN2
2protein processingGO:01648512.3NCSTN, PSEN2, PSENEN, PSEN1, CASP2, CASP3
3neurotrophin TRK receptor signaling pathwayGO:04801112.2CASP3, CASP2, PSENEN, PSEN2, NCSTN, GSK3B
4apoptotic signaling pathwayGO:09719012.0CASP3, CASP2, PSENEN, PSEN2, NCSTN
5Notch signaling pathwayGO:00721912.0NCSTN, PSEN2, PSENEN, PSEN1, APP
6proteolysisGO:00650811.9CASP3, CASP2, NCSTN, BLMH, ACE
7negative regulation of apoptotic processGO:04306611.9CASP3, PSEN1, PSEN2, MPO, GSK3B
8amyloid precursor protein catabolic processGO:04298711.8PSEN1, PSENEN, PSEN2, NCSTN
9Notch receptor processingGO:00722011.8PSEN1, PSENEN, PSEN2, NCSTN
10membrane protein ectodomain proteolysisGO:00650911.8NCSTN, PSEN2, PSENEN, PSEN1
11positive regulation of catalytic activityGO:04308511.8PSEN1, PSENEN, PSEN2, NCSTN
12beta-amyloid metabolic processGO:05043511.5PSEN1, PSEN2, NCSTN
13membrane protein intracellular domain proteolysisGO:03129311.5NCSTN, PSEN2, PSENEN
14regulation of protein bindingGO:04339311.5APP, PSEN1, PSEN2
15neuron apoptotic processGO:05140211.5CASP3, APP, PSEN1
16positive regulation of neuron apoptotic processGO:04352511.5CDK5R1, CASP2, CASP3
17response to oxidative stressGO:00697911.3APP, PSEN1, MPO
18positive regulation of coagulationGO:05082011.3PSEN2, PSEN1
19smooth endoplasmic reticulum calcium ion homeostasisGO:05156311.3PSEN1, APP
20myeloid leukocyte differentiationGO:00257311.3PSEN2, PSEN1
21regulation of epidermal growth factor-activated receptor activityGO:00717611.2APP, PSEN2
22T cell activation involved in immune responseGO:00228611.2PSEN1, PSEN2
23endoplasmic reticulum calcium ion homeostasisGO:03246911.2PSEN2, PSEN1
24ionotropic glutamate receptor signaling pathwayGO:03523511.2CDK5R1, APP
25neuron migrationGO:00176411.2CDK5R1, PSEN1, APBB1
26epithelial cell proliferationGO:05067311.2NCSTN, PSEN1
27regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328111.1CASP3, CASP2
28anagenGO:04264011.1PSEN1, PSEN2
29low-density lipoprotein particle remodelingGO:03437411.1APOE, MPO
30antigen processing and presentation of peptide antigen via MHC class IGO:00247411.1HLA-H, HFE, BLMH
31regulation of neuronal synaptic plasticityGO:04816811.0GSK3B, APOE
32brain morphogenesisGO:04885410.9PSEN2, PSEN1
33dorsal/ventral neural tube patterningGO:02190410.6PSEN2, PSEN1

Molecular functions related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.3PSEN1, APBB1, APBA2, APOE, APP, CASP2
2beta-amyloid bindingGO:00154011.6APBB1, APBA2, APOE, COL25A1
3endopeptidase activityGO:00417511.5PSEN1, PSEN2, NCSTN, ACE
4heparin bindingGO:00820111.4COL25A1, APP, APOE, MPO
5cysteine-type endopeptidase activityGO:00419711.1BLMH, CASP2, CASP3
6carboxypeptidase activityGO:00418010.9ACE, BLMH
7tau protein bindingGO:04815610.6GSK3B, APOE

Products for genes affiliated with Alzheimer's Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alzheimer's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet