AD
MCID: ALZ001
MIFTS: 103

Alzheimer's Disease (AD) malady

Neuronal diseases, Genetic diseases categories

Summaries for Alzheimer's Disease

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 43NINDS, 45Novus Biologicals, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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MedlinePlus:33 Alzheimer's disease (ad) is the most common form of dementia among older people. dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. ad begins slowly. it first involves the parts of the brain that control thought, memory and language. people with ad may have trouble remembering things that happened recently or names of people they know. a related problem, mild cognitive impairment (mci), causes more memory problems than normal for people of the same age. many, but not all, people with mci will develop ad. in ad, over time, symptoms get worse. people may not recognize family members or have trouble speaking, reading or writing. they may forget how to brush their teeth or comb their hair. later on, they may become anxious or aggressive, or wander away from home. eventually, they need total care. this can cause great stress for family members who must care for them. ad usually begins after age 60. the risk goes up as you get older. your risk is also higher if a family member has had the disease. no treatment can stop the disease. however, some drugs may help keep symptoms from getting worse for a limited time. nih: national institute on aging

MalaCards: Alzheimer's Disease, also known as alzheimer disease, is related to dementia and vascular dementia. An important gene associated with Alzheimer's Disease is A2M (alpha-2-macroglobulin), and among its related pathways are Neuroscience and Signaling by GPCR. The drugs galantamine and selegiline and the compounds cholesterol and lipid have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are mortality/aging and behavior/neurological.

Disease Ontology:8 A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. it is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

Genetics Home Reference:21 Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.

NIH Rare Diseases:42 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

CDC:3 Alzheimer’s disease is the most common form of dementia among older adults. Alzheimer’s disease involves parts of the brain that control thought, memory, and language and can seriously affect a person’s ability to carry out daily activities. Although scientists are learning more every day, right now, they still do not know what causes Alzheimer’s disease.

NINDS:43 Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.

Novus Biologicals:45 Alzheimer's Disease (AD) is the most common form of dementia that affects 5.3 million Americans. AD causes the damage and destruction of nerves in the brain. Hallmark abnormalities include deposits of beta-amyloid (plaques) and twisted strands of tau (tangles). Beta-amyloid peptide, a protein derived from amyloid precursor protein (APP), aggregates into a beta-pleated sheet configuration which is neurotoxic and forms the core of neuritic plaques. These abnormalities disrupt cellular communication, cause damage via oxidative metabolism, initiate abnormal accumulation of cytoskeletal proteins and result in cell death. Genes identified as causing susceptibility to Alzheimer's disease do not singly cause the disease state, but when combined with other epigenetic and environmental factors can lead to the condition.

Wikipedia:63 Alzheimer\'s disease (AD), also known in medical literature as Alzheimer disease, is the most common... more...

Description from OMIM:46 104310,606889,607822,104300

GeneReviews summary for alzheimer

Aliases & Classifications for Alzheimer's Disease

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Sources:
8Disease Ontology, 63Wikipedia, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

alzheimer's disease 8 63 21 43 33 30 60
alzheimer disease 19 42 20 22 21 46
familial alzheimer disease 63 42 21
ad 8 63 21
primary senile degenerative dementia 63 21
presenile and senile dementia 63 21
alzheimers disease 10 44
sdat 63 21
dementia in alzheimer's disease, unspecified 8
dementia of the alzheimer's type 8
dat - dementia alzheimer's type 63
dementia in alzheimer's disease 8
alzheimer disease, familial 60
alzheimer disease familial 42
alzheimer-type dementia 21
alzheimers dementia 8
alzheimer sclerosis 21
alzheimer syndrome 21
alzheimer dementia 21
alstrom syndrome 60
dat 21
fad 42


Related Diseases for Alzheimer's Disease

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Alzheimer's Disease family:

Alzheimer Disease Type 1 Alzheimer Disease Type 2
Alzheimer Disease Type 3 Alzheimer Disease Type 4
Alzheimer Disease Type 5 Alzheimer Disease-13
Alzheimer Disease-14 Alzheimer Disease-15
Alzheimer Disease 17 Alzheimer Disease-10
Alzheimer Disease 12 Alzheimer Disease-11
Alzheimer Disease-7 Alzheimer Disease 6
Alzheimer Disease 18 Alzheimer Disease 9, Late Onset
Alzheimer Disease 8 Alzheimer Disease 1, Familial
Alzheimer Disease 16

Diseases related to Alzheimer's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 486)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.2PSENEN, PSEN1, GSK3B, BLMH, APP, CHAT
2vascular dementia30.6APOE
3alzheimer disease type 130.5PSEN1, APP, PSEN2
4hypertension30.4APOE, ACE
5diabetes mellitus30.4CASP3, HFE, ACE, APOE
6obesity30.4HFE, APOE
7amyloidosis30.4APBB1, APOE, APP, PSEN1, PSEN2
8amyotrophic lateral sclerosis30.4APP, CASP3, PSEN1, CHAT
9leukemia30.3CASP3, CDK5R1, CHAT, HFE, MPO, CASP2
10progressive supranuclear palsy30.3APOE
11breast cancer30.2CASP2, CASP3, PSEN2, CDK5R1
12hepatitis30.2HFE
13myocardial infarction30.1ACE, APOE, HFE
14vascular disease30.1CASP3
15schizophrenia30.0PSEN1, CHAT, GSK3B
16pancreatitis30.0MPO
17pick's disease30.0PSEN1, CHAT, APP, APOE
18frontotemporal dementia30.0APP, APOE, PSEN1, PSEN2
19acute myocardial infarction30.0ACE
20brain disease30.0CHAT, APP, PSEN1
21alzheimer disease type 230.0PSEN1, APOE, APP, GSK3B, PSEN2
22atherosclerosis29.9MPO, ACE, APOE
23colorectal cancer29.9CASP3, CASP2
24peritonitis29.9MPO
25lung cancer29.9APP
26cadasil29.8CHAT, APOE, ACE, PSEN1
27ischemia29.8CDK5R1, MPO, CHAT, CASP2, CASP3, PSEN1
28prostate cancer29.8CASP2, GSK3B, HFE, CASP3
29hepatocellular carcinoma29.8PSEN2, HFE, CASP3
30multiple sclerosis29.8APOE
31myeloma29.8CASP3
32hepatitis c29.8HFE
33hepatitis b29.8HFE
34parkinson's disease29.6CHAT, CDK5R1, CASP3, APP, APOE, PSEN1
35down syndrome29.6APP, APOE, PSEN1, PSEN2, CHAT
36cerebral amyloid angiopathy29.6APOE, PSEN1, APP
37prion disease29.6PSEN1, PSEN2, APP
38neuroblastoma29.6PSENEN, CHAT
39hemochromatosis29.6HFE, HLA-H
40hidradenitis suppurativa29.6NCSTN, PSENEN
41myositis29.6PSEN1, APP
42age related macular degeneration29.6APOE
43inclusion body myositis29.6APP
44acute pancreatitis29.6MPO
45lewy body dementia29.6APOE
46cystic fibrosis29.6MPO
47dilated cardiomyopathy29.6ACE
48alstrom syndrome10.8
49hyperlipidemia type 310.7
50fetal akinesia deformation sequence10.3

Graphical network of the top 20 diseases related to Alzheimer's Disease:



Diseases related to alzheimer's disease

Clinical Features for Alzheimer's Disease

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

104310,606889,607822,104300

Drugs & Therapeutics for Alzheimer's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alzheimer's Disease

Drug clinical trials:

Search ClinicalTrials for Alzheimer's Disease

Search NIH Clinical Center for Alzheimer's Disease

Search CenterWatch for Alzheimer's Disease

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Alzheimer's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alzheimer's Disease:
NEUROSTEM
Embryonic/Adult Cultured Cells Related to Alzheimer's Disease:
Umbilical cord blood-derived mesenchymal stem/progenitor cells , PMIDs: 23293711, 22015609

Genetic Tests for Alzheimer's Disease

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20GeneTests, 22GTR
See all sources

Genetic tests related to Alzheimer's Disease:

id Genetic test Affiliating Genes
1 Alzheimer Disease20
2 Alzheimer's Disease22

Anatomical Context for Alzheimer's Disease

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Alzheimer's Disease:

32
Brain, Cortex, Testes, Endothelial, Temporal lobe, Amygdala, Liver, Monocytes, Cerebellum, Heart, T cells, Prefrontal cortex, Skin, Hypothalamus, Eye, Thyroid, Smooth muscle, Thalamus, Occipital lobe, Placenta, Breast, Retina, Caudate nucleus, Olfactory bulb, Cingulate cortex, Spinal cord, Kidney, Adrenal gland, Adrenal cortex, Myeloid, Pituitary, Pineal, Prostate, Subthalamic nucleus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alzheimer's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
3 BrainHippocampus  Affected by disease

Animal Models for Alzheimer's Disease or affiliated genes

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36MGI
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Publications for Alzheimer's Disease

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50PubMed
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Articles related to Alzheimer's Disease:

(show top 50)    (show all 6770)
idTitleAuthorsYear
1
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. (24252572)
2013
2
Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42. (24380241)
2013
3
TREM2 variants in Alzheimer's disease. (23150934)
2013
4
Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients. (23153928)
2013
5
A polymorphic microsatellite repeat within the ECE-1c promoter is involved in transcriptional start site determination, human evolution, and Alzheimer's disease. (23175834)
2012
6
The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease. (22879628)
2012
7
Linkage to the 8p21.1 region Including the CLU gene in age at onset stratified alzheimer's disease families. (20930273)
2011
8
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain. (21062360)
2011
9
Posterior cortical atrophy: evidence for discrete syndromes of early-onset Alzheimer's disease. (21831859)
2011
10
Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease. (19897004)
2010
11
S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10. (19159013)
2009
12
Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. (18363936)
2008
13
APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway. (18416843)
2008
14
Genetic association between SORL1 polymorphisms and Alzheimer's disease in a Japanese population. (18685254)
2008
15
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells. (18422760)
2008
16
Aluminium blunts the proliferative response and increases apoptosis of cultured human cells: putative relationship to Alzheimer's disease. (18084647)
2007
17
Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism. (18045146)
2007
18
Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study. (17457030)
2007
19
Cognitive impairment in Alzheimer's disease is modified by APOE genotype. (17596691)
2007
20
Phospholipase D1 is associated with amyloid precursor protein in Alzheimer's disease. (16797788)
2007
21
Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease. (17267522)
2007
22
Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease. (16650578)
2006
23
Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects. (16551433)
2006
24
Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial. (16866904)
2006
25
Acetylcholinesterase inhibitors for the treatment of dementia in Alzheimer's disease: do we need new inhibitors? (16262564)
2005
26
Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population. (15389771)
2004
27
The beta-amyloid cascade hypothesis: a sequence of events leading to neurodegeneration in Alzheimer's disease]. (15565529)
2004
28
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. (14970312)
2004
29
Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain. (15610181)
2004
30
No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease. (15082191)
2004
31
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. (12641733)
2003
32
The efficacy of galantamine in the treatment of Alzheimer's disease: comparison of patients previously treated with acetylcholinesterase inhibitors to patients with no prior exposure. (12673604)
2003
33
APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: implications for late-onset Alzheimer's disease. (12169205)
2002
34
Contrasting species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. (11784781)
2002
35
Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. (11278424)
2001
36
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E. (10841982)
2000
37
Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease. (11016543)
2000
38
Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination? (10854108)
2000
39
The pharmacology of donepezil: a new treatment of Alzheimer's disease. (11249555)
1999
40
Proteins with frameshift mutations in Alzheimer's disease; cause or effect?]. (9749295)
1998
41
Identification of a novel mutation (Leu282Arg) of the human presenilin 1 gene in Alzheimer's disease. (9502232)
1998
42
The neuropsychological pattern of corticobasal degeneration: comparison with progressive supranuclear palsy and Alzheimer's disease. (7644044)
1995
43
The SEC receptor: a possible link between neonatal hepatitis in alpha 1-antitrypsin deficiency and Alzheimer's disease. (7808820)
1994
44
Regional brain activity of free radical defense enzymes in autopsy samples from patients with Alzheimer's disease and from nondemented controls. (8050854)
1994
45
Neurotrophic strategies for treating Alzheimer's disease: lessons from basic neurobiology and animal models. (8239298)
1993
46
Low cerebrospinal-fluid concentrations of soluble amyloid beta-protein precursor in hereditary Alzheimer's disease. (1354785)
1992
47
Ubiquitin expression in globose tangles in the locus coeruleus in brains of patients with Alzheimer's and Parkinson's diseases. (1321968)
1992
48
Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease. (1628221)
1992
49
Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence. (1791986)
1991
50
Retrograde amnesia in patients with Alzheimer's disease or Huntington's disease. (2967441)
1988

Genetic Variations for Alzheimer's Disease

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Alzheimer's Disease:

62 (show all 13)
id Symbol AA change Variation ID SNP ID
1APPp.Ala692GlyVAR_000016
2APPp.Ala713ThrVAR_000019
3APPp.Ile716ValVAR_000020
4APPp.Val717IleVAR_000021
5APPp.Val717GlyVAR_000022
6APPp.Val717PheVAR_000023
7APPp.Val715MetVAR_010108
8APPp.Leu723ProVAR_010109
9APPp.Glu693GlyVAR_014215
10APPp.Thr714IleVAR_014218
11APPp.Val717LeuVAR_014219
12APPp.Thr714AlaVAR_032277
13APPp.Asp678AsnVAR_044424

Expression for genes affiliated with Alzheimer's Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alzheimer's Disease

Search GEO for disease gene expression data for Alzheimer's Disease.

Pathways for genes affiliated with Alzheimer's Disease

About this section
Sources:
4Cell Signaling Technology, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 12EMD Millipore, 55SinoBiological, 59Tocris Bioscience
See all sources

Pathways related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.8APBA2, APOE, APP, PSEN1, PSENEN, PSEN2
2
Hide members
12.3NCSTN, APOE, APP, A2M, PSEN2, PSENEN
3
Hide members
12.3PSENEN, NCSTN, PSEN2, PSEN1, APBB1, APP
412.1PSEN1, APP, APOE, PSEN2, A2M, CDK5R1
512.1CASP3, PSEN2, GSK3B, NCSTN, PSEN1, APP
611.9ACE, PSENEN, NCSTN, PSEN2, PSEN1, APP
7
Hide members
11.9PSENEN, APP, PSEN1, GSK3B, NCSTN, PSEN2
811.9PSENEN, APOE, PSEN2, NCSTN, GSK3B, APP
9
Hide members
11.9PSEN1, COL25A1, GSK3B, NCSTN, PSEN2, CASP3
1011.6PSEN1, PSENEN, PSEN2, NCSTN, GSK3B
1111.6GSK3B, CDK5R1, APBB1, APOE, APP
1211.6NCSTN, PSEN1, PSENEN, APP, CASP3
13
Hide members
11.6PSEN2, GSK3B, PSEN1, CASP3, CDK5R1
14
Hide members
11.6PSENEN, CASP3, NCSTN, CASP2, PSEN2
15
Hide members
11.6CASP3, NCSTN, PSEN2, PSENEN, CASP2
1611.4ACE, A2M, APOE, APP
1711.4PSEN2, PSENEN, PSEN1, NCSTN
18
Hide members
11.4NCSTN, PSEN1, PSEN2, PSENEN
1911.4PSEN1, PSENEN, PSEN2, NCSTN
2011.4GSK3B, PSEN1, PSENEN, NCSTN
21
Hide members
11.4GSK3B, NCSTN, PSEN2, PSENEN
22
Hide members
11.4CASP3, CASP2, APP, GSK3B
2311.2PSEN2, PSENEN, PSEN1
2411.2PSENEN, NCSTN, PSEN1
25
Hide members
11.2NCSTN, PSENEN, PSEN2
26
Hide members
11.2PSEN2, NCSTN, PSENEN
27
Hide members
11.2PSENEN, PSEN2, NCSTN
28
Hide members
11.2PSENEN, PSEN2, NCSTN
29
Apoptosis and survival Caspase cascade
Hide members
11.2CASP3, APP, CASP2
3011.2GSK3B, CDK5R1, CASP3
31
Hide members
10.9PSENEN, NCSTN
3210.9CASP3, CASP2

Compounds for genes affiliated with Alzheimer's Disease

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
See all sources

Compounds related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1cholesterol44 28 11 2416.2A2M, NCSTN, CASP2, APP, PSEN1, PSENEN
2lipid4413.2APOE, CASP2, APP, PSEN1, PSENEN, NCSTN
3serine4413.2APOE, PSEN2, A2M, PSEN1, APP, CASP2
4retinoic acid44 2413.8CASP2, CASP3, APP, PSEN1, PSEN2, MPO
5cysteine4412.7HFE, CASP3, CASP2, APP, APOE, PSEN1
64-hydroxynonenal44 2413.6APP, PSEN1, MPO, CHAT, CASP3, CASP2
7lactacystin4412.3PSENEN, PSEN2, APOE, PSEN1, APP, CASP3
8potassium44 11 2414.3CASP2, GSK3B, CHAT, PSEN2, PSEN1, ACE
9aspartate4412.3PSEN2, PSEN1, CHAT, APOE, HFE, APP
10testosterone44 59 11 2415.3CASP2, APP, APOE, CHAT, GSK3B, HFE
11oligonucleotide4412.2CDK5R1, CHAT, PSEN2, HFE, CASP2, PSEN1
12nitric oxide44 11 2414.2CASP2, MPO, PSEN1, CHAT, ACE, PSEN2
13alanine4412.1GSK3B, PSEN1, CHAT, HFE, APOE, APP
14valine4412.1MPO, PSEN1, APOE, APP, PSEN2
15butyrate4412.0MPO, CASP3, CASP2, CHAT, APP
16acetylcholine44 49 28 11 2416.0APOE, APP, MPO, CHAT, ACE
17glycogen44 2413.0CDK5R1, CHAT, GSK3B, PSEN1, APBB1
18paraffin4412.0CASP2, APOE, PSEN2, MPO, CHAT
19lactate4411.9BLMH, MPO, PSEN2, CHAT, CASP3
20glutamate4411.9PSEN2, PSEN1, CHAT, APP, CDK5R1
21h2o24411.8PSEN2, PSEN1, MPO, CASP2
22choline44 11 2413.8APP, PSEN1, PSEN2, CHAT
23sterol4411.8CASP2, APOE, PSENEN, PSEN1
24dapt5911.6PSEN2, PSEN1, PSENEN
25l-685,4585911.6PSEN2, PSENEN, PSEN1
26jlk 65911.6PSENEN, PSEN2, PSEN1
27begacestat5911.6PSENEN, PSEN2, PSEN1
28mrk 5605911.6PSEN2, PSENEN, PSEN1
29donepezil44 11 2413.6APOE, APP, CHAT
306-hydroxydopamine4411.5CHAT, APP, CASP3
31kininogen4411.4APP, ACE, MPO
32vitamin b124411.4MPO, APOE, PSEN1
33malondialdehyde4411.4PSEN1, CHAT, MPO
34ab-424411.3APP, PSEN2
35s-1824411.3PSEN2, PSEN1
36daunorubicin44 49 1113.3MPO, CASP3, CASP2
37Indirubin-3'-Monoxime1111.3CDK5R1, GSK3B
38thioflavine s4411.3APP, APOE
39peroxynitrite4411.3CASP2, PSEN1, MPO
40huperzine a4411.3APP, CHAT
41Human Serum Albumin1111.3APOE, MPO
42dihydralazine4411.3MPO, ACE
43metrifonate4411.3APOE, APP
4424s-hydroxy-cholesterol4411.2APP, APOE
45polyadenosine diphosphate ribose4411.1CASP3, CASP2
46ascorbic acid44 2412.1CASP2, APOE, HFE, MPO
47propentofylline4411.0APP, CHAT
48physostigmine44 1111.9APP, CHAT
49bleomycin44 1111.9BLMH, APOE
50cycloheximide4410.8PSEN1, PSEN2

GO Terms for genes affiliated with Alzheimer's Disease

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Sources:
16Gene Ontology
See all sources

Cellular components related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588613.7COL25A1, HFE, CASP3, APP, APOE, GSK3B
2cytosolGO:00582912.5APP, CASP2, PSEN2, CASP3, CHAT, BLMH
3integral to plasma membraneGO:00588712.4NCSTN, HFE, HLA-H, PSEN2, PSENEN, PSEN1
4neuronal cell bodyGO:04302512.1CDK5R1, CHAT, PSEN2, PSEN1, APOE, GSK3B
5perinuclear region of cytoplasmGO:04847111.9GSK3B, CDK5R1, HFE, PSEN2, PSEN1, APP
6growth coneGO:03042611.9GSK3B, PSEN1, APBB1, CDK5R1, PSEN2
7Golgi apparatusGO:00579411.9NCSTN, PSENEN, PSEN2, APOE, APP, PSEN1
8axonGO:03042411.8APP, PSEN1, PSEN2, CHAT, CDK5R1
9dendritic shaftGO:04319811.7APP, PSEN1, PSEN2, GSK3B
10neuromuscular junctionGO:03159411.6APP, PSEN2, CDK5R1, PSEN1
11ciliary rootletGO:03525311.4PSEN2, APP, PSEN1
12MHC class I protein complexGO:04261210.9HFE, HLA-H
13dendritic spineGO:04319710.9APP, CDK5R1, GSK3B

Biological processes related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of apoptotic processGO:04306512.5CASP3, NCSTN, CASP2, APBB1, PSEN1, PSENEN
2protein processingGO:01648512.3CASP3, NCSTN, PSEN1, PSEN2, PSENEN, CASP2
3neurotrophin TRK receptor signaling pathwayGO:04801112.2CASP3, PSENEN, PSEN2, NCSTN, GSK3B, CASP2
4apoptotic signaling pathwayGO:09719012.0CASP2, PSENEN, PSEN2, NCSTN, CASP3
5Notch signaling pathwayGO:00721912.0PSEN1, APP, PSENEN, NCSTN, PSEN2
6proteolysisGO:00650811.9CASP2, ACE, CASP3, BLMH, NCSTN
7negative regulation of apoptotic processGO:04306611.9PSEN1, GSK3B, MPO, PSEN2, CASP3
8amyloid precursor protein catabolic processGO:04298711.8PSEN2, NCSTN, PSENEN, PSEN1
9Notch receptor processingGO:00722011.8PSEN1, PSENEN, NCSTN, PSEN2
10membrane protein ectodomain proteolysisGO:00650911.8PSEN1, PSENEN, PSEN2, NCSTN
11positive regulation of catalytic activityGO:04308511.8PSENEN, PSEN1, PSEN2, NCSTN
12beta-amyloid metabolic processGO:05043511.5PSEN2, NCSTN, PSEN1
13membrane protein intracellular domain proteolysisGO:03129311.5PSENEN, PSEN2, NCSTN
14regulation of protein bindingGO:04339311.5PSEN2, PSEN1, APP
15neuron apoptotic processGO:05140211.5CASP3, APP, PSEN1
16positive regulation of neuron apoptotic processGO:04352511.5CASP3, CDK5R1, CASP2
17response to oxidative stressGO:00697911.3MPO, APP, PSEN1
18smooth endoplasmic reticulum calcium ion homeostasisGO:05156311.3APP, PSEN1
19positive regulation of coagulationGO:05082011.3PSEN2, PSEN1
20myeloid leukocyte differentiationGO:00257311.3PSEN1, PSEN2
21regulation of epidermal growth factor-activated receptor activityGO:00717611.2PSEN2, APP
22T cell activation involved in immune responseGO:00228611.2PSEN1, PSEN2
23endoplasmic reticulum calcium ion homeostasisGO:03246911.2PSEN2, PSEN1
24ionotropic glutamate receptor signaling pathwayGO:03523511.2APP, CDK5R1
25neuron migrationGO:00176411.2APBB1, PSEN1, CDK5R1
26epithelial cell proliferationGO:05067311.2PSEN1, NCSTN
27regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328111.1CASP2, CASP3
28anagenGO:04264011.1PSEN2, PSEN1
29low-density lipoprotein particle remodelingGO:03437411.1MPO, APOE
30antigen processing and presentation of peptide antigen via MHC class IGO:00247411.1BLMH, HFE, HLA-H
31regulation of neuronal synaptic plasticityGO:04816811.0APOE, GSK3B
32brain morphogenesisGO:04885410.9PSEN1, PSEN2
33dorsal/ventral neural tube patterningGO:02190410.6PSEN1, PSEN2

Molecular functions related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551514.3PSEN2, PSENEN, PSEN1, APBB1, APBA2, APOE
2beta-amyloid bindingGO:00154011.6APBB1, APBA2, APOE, COL25A1
3endopeptidase activityGO:00417511.5PSEN1, PSEN2, NCSTN, ACE
4heparin bindingGO:00820111.4APOE, MPO, COL25A1, APP
5cysteine-type endopeptidase activityGO:00419711.1BLMH, CASP3, CASP2
6carboxypeptidase activityGO:00418010.9ACE, BLMH
7tau protein bindingGO:04815610.6GSK3B, APOE

Products for genes affiliated with Alzheimer's Disease

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Sources for Alzheimer's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet