AD
MCID: ALZ001
MIFTS: 100

Alzheimer's Disease (AD) malady

Genetic diseases, Rare diseases, Mental diseases, Neuronal diseases categories
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Summaries for Alzheimer's Disease

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MedlinePlus:33 Alzheimer's disease (ad) is the most common form of dementia among older people. dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. ad begins slowly. it first involves the parts of the brain that control thought, memory and language. people with ad may have trouble remembering things that happened recently or names of people they know. a related problem, mild cognitive impairment (mci), causes more memory problems than normal for people of the same age. many, but not all, people with mci will develop ad. in ad, over time, symptoms get worse. people may not recognize family members or have trouble speaking, reading or writing. they may forget how to brush their teeth or comb their hair. later on, they may become anxious or aggressive, or wander away from home. eventually, they need total care. this can cause great stress for family members who must care for them. ad usually begins after age 60. the risk goes up as you get older. your risk is also higher if a family member has had the disease. no treatment can stop the disease. however, some drugs may help keep symptoms from getting worse for a limited time. nih: national institute on aging

MalaCards based summary: Alzheimer's Disease, also known as alzheimer disease, is related to dementia and alzheimer disease type 1. An important gene associated with Alzheimer's Disease is A2M (alpha-2-macroglobulin), and among its related pathways are Alzheimers Disease Pathway and A-beta Plaque Formation and APP Metabolism. The drugs galantamine and selegiline and the compounds cholesterol and serine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A dementia and a tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. it is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

Genetics Home Reference:21 Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.

NIH Rare Diseases:42 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

CDC:3 Although scientists are learning more every day, right now, they still do not know what causes AlzheimerÔÇÖs disease.

NINDS:43 Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.

Novus Biologicals:45 Alzheimer's Disease (AD) is the most common form of dementia that affects 5.3 million Americans. AD causes the damage and destruction of nerves in the brain. Hallmark abnormalities include deposits of beta-amyloid (plaques) and twisted strands of tau (tangles). Beta-amyloid peptide, a protein derived from amyloid precursor protein (APP), aggregates into a beta-pleated sheet configuration which is neurotoxic and forms the core of neuritic plaques. These abnormalities disrupt cellular communication, cause damage via oxidative metabolism, initiate abnormal accumulation of cytoskeletal proteins and result in cell death. Genes identified as causing susceptibility to Alzheimer's disease do not singly cause the disease state, but when combined with other epigenetic and environmental factors can lead to the condition.

Wikipedia:65 Alzheimer\'s disease (AD), also known as Alzheimer disease, is the most common form of dementia. There... more...

Descriptions from OMIM:46 605526, 104310, 607116, 611154, 607822 611152, 606187, 104300, 606889, 300756, 615080, 611155, 608907, 609636, 609790, 611073, 602096 more

GeneReviews summary for alzheimer

Aliases & Classifications for Alzheimer's Disease

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Alzheimer's Disease, Aliases & Descriptions:

Name: Alzheimer's Disease 30 8 65 21 43 33 62
Alzheimer Disease 8 19 42 20 22 21 46
Primary Senile Degenerative Dementia 65 21 62
Familial Alzheimer Disease 65 42 21
Ad 8 65 21
Presenile and Senile Dementia 65 21
Alzheimers Dementia 8 62
Alzheimer Sclerosis 21 62
Alzheimers Disease 10 44
Alzheimer Syndrome 21 62
Sdat 65 21
 
Dementia of the Alzheimer's Type 8
Dementia in Alzheimer's Disease 8
Dat - Dementia Alzheimer's Type 65
Alzheimer Disease, Familial 62
Alzheimer Disease Familial 42
Dementia, Alzheimer Type 62
Alzheimer-Type Dementia 21
Alzheimer Dementia 21
Fad 42
Dat 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases, Neuronal diseases


Related Diseases for Alzheimer's Disease

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Diseases in the Alzheimer's Disease family:

Alzheimer Disease Type 1 Alzheimer Disease Type 2
Alzheimer Disease Type 3 Alzheimer Disease Type 4
Alzheimer Disease Type 5 Alzheimer Disease-13
Alzheimer Disease-14 Alzheimer Disease-15
Alzheimer Disease 17 Alzheimer Disease-10
Alzheimer Disease 12 Alzheimer Disease-11
Alzheimer Disease-7 Alzheimer Disease 6
Alzheimer Disease 18 Alzheimer Disease 9, Late Onset
Alzheimer Disease 19, Late Onset Alzheimer Disease 8
Alzheimer Disease 1, Familial Alzheimer Disease 16

Diseases related to Alzheimer's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1dementia32.3APOE, APP, BLMH, GSK3B, PSEN2, PSEN1
2alzheimer disease type 131.9PSEN2, PSEN1, APP
3vascular dementia31.6PSEN1, APP, APOE
4amyloidosis31.4APOE, CTSD, PSEN2, PSEN1, APP
5frontotemporal dementia31.2APOE, PSEN1, APP, PSEN2
6alzheimer disease 631.1AD6
7progressive supranuclear palsy31.1APOE, APP
8alzheimer disease type 231.1CTSD, GSK3B, PSEN2, PSEN1, APP, APOE
9pick's disease31.1PSEN1, APP, APOE
10memory impairment31.0APOE, APP, PSEN1
11bipolar disorder30.9PSEN2, GSK3B
12cerebrovascular disease30.9APOE, APP, ACE
13prion disease30.7APP, PSEN2, PSEN1
14down syndrome30.7APP, PSEN2, PSEN1, APOE
15tauopathy30.6PSEN1, APP
16parkinson's disease30.6GSK3B, PSEN1, APP, APOE
17cerebral amyloid angiopathy30.6APP
18amyotrophic lateral sclerosis type 1430.6APP, PSEN1
19age related macular degeneration30.6APOE, CTSD
20inclusion body myositis30.6APP
21diabetic nephropathy30.5APOE, HFE, ACE
22lewy body dementia30.5APOE, APP
23vascular disease30.4APOE, PSEN1, ACE
24creutzfeldt-jakob disease30.4APOE, APP
25hyperlipidemia type 310.8
26hemorrhage, intracerebral10.7PSEN1, PSEN2, APP, APOE
27amyloid tumor10.7APOE, APP, PSEN2, PSEN1
28binswanger's disease10.6APP, APOE
29stroke, hemorrhagic10.6APOE, APP
30microvascular complications of diabetes 710.6HFE
31huntington's disease10.6APP, PSEN2, PSEN1
32nephrotic syndrome10.6APOE, ACE, A2M
33porphyria cutanea tarda10.5HFE
34coronary artery anomaly10.5HFE, ACE, APOE
35alzheimer disease type 310.5
36alzheimer disease type 410.5
37hypertension10.4
38diabetes mellitus10.3
39obesity10.3
40spastic paraparesis10.3
41blindness10.3
42dermatitis10.3
43hydrocephalus10.3
44normal pressure hydrocephalus10.3
45atopic dermatitis10.3
46leukemia10.2
47cerebritis10.2
48breast cancer10.2
49hypercholesterolemia10.2
50immunodeficiency 27b, mycobacteriosis, ad10.2

Graphical network of the top 20 diseases related to Alzheimer's Disease:



Diseases related to alzheimer's disease

Symptoms for Alzheimer's Disease

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Drugs & Therapeutics for Alzheimer's Disease

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Drug clinical trials:

Search ClinicalTrials for Alzheimer's Disease

Search NIH Clinical Center for Alzheimer's Disease

Inferred drug relations via UMLS62/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Alzheimer's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alzheimer's Disease:
NEUROSTEM
Embryonic/Adult Cultured Cells Related to Alzheimer's Disease:
Umbilical cord blood-derived mesenchymal stem/progenitor cells , PMIDs: 23293711, 22015609

Genetic Tests for Alzheimer's Disease

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Genetic tests related to Alzheimer's Disease:

id Genetic test Affiliating Genes
1 Alzheimer Disease20
2 Alzheimer's Disease22

Anatomical Context for Alzheimer's Disease

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MalaCards organs/tissues related to Alzheimer's Disease:

32
Brain, Cortex, Testes, Endothelial, Temporal lobe, Monocytes, Amygdala, Liver, Cerebellum, Heart, Skin, T cells, Prefrontal cortex, Hypothalamus, Neutrophil, Smooth muscle, Thyroid, Eye, Retina, Breast, Placenta, Myeloid, Occipital lobe, Olfactory bulb, Thalamus, Caudate nucleus, Spinal cord, Kidney, Adrenal gland, Prostate, B cells, Cingulate cortex, Subthalamic nucleus, Adrenal cortex, Pineal, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alzheimer's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
3 BrainHippocampus  Affected by disease

Animal Models for Alzheimer's Disease or affiliated genes

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MGI Mouse Phenotypes related to Alzheimer's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0HFE, CTSD, GSK3B, BLMH, ACE, PSEN2
2MP:000537610.9GSK3B, PSEN2, HFE, ACE, PSEN1, MPO
3MP:000538610.9HFE, GSK3B, CTSD, PSEN1, ACE, PSEN2
4MP:001076810.9BLMH, GSK3B, CTSD, APOE, APP, PSEN1
5MP:000537810.8PSEN2, HFE, PSEN1, CTSD, GSK3B, ACE
6MP:000538110.6APOE, PSEN1, PSEN2, HFE, GSK3B, CTSD
7MP:000537910.6APOE, PSEN1, PSEN2, ACE, GSK3B, CTSD
8MP:000537110.5PSEN1, PSEN2, HFE, BLMH, APOE
9MP:000538510.4APOE, BLMH, PSEN1, PSEN2, ACE, GSK3B

Publications for Alzheimer's Disease

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Articles related to Alzheimer's Disease:

(show top 50)    (show all 6838)
idTitleAuthorsYear
1
Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI), and Alzheimer's disease (AD). (24902808)
2014
2
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. (24252572)
2013
3
The APOE E94/E94 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. (23652625)
2013
4
Screening of microRNAs associated with Alzheimer's disease using oxidative stress cell model and different strains of senescence accelerated mice. (24423585)
2013
5
AI^38 in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models. (24305500)
2013
6
No diagnostic value of plasma clusterin in Alzheimer's disease. (23209684)
2012
7
Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. (22349685)
2012
8
Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes. (22580620)
2012
9
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
10
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. (22926141)
2012
11
Apolipoprotein E I/4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis. (21124030)
2011
12
Cerebrospinal fluid profile of amyloid I^42 (AI^42), hTau and ubiquitin in North Indian Alzheimer's disease patients. (20599474)
2011
13
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
14
Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment. (19836440)
2010
15
Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease. (19897004)
2010
16
Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex. (21034788)
2010
17
Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. (20025970)
2010
18
Efficient processing of Alzheimer's disease amyloid-Beta peptides by neuroectodermally converted mesenchymal stem cells. (19469700)
2010
19
Clinical features of rapidly progressive Alzheimer's disease. (20453509)
2010
20
Critical evaluation of self-rated quality of life in mild cognitive impairment and Alzheimer's disease--further evidence for the impact of anosognosia and global cognitive impairment. (19262958)
2009
21
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. (19374444)
2009
22
An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. (19016491)
2009
23
Impact of rivastigmine on caregiver burden associated with Alzheimer's disease in both informal care and nursing home settings. (18582146)
2008
24
Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. (18363936)
2008
25
Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet? (18327642)
2008
26
Reduced insulin-induced phosphatidylinositol-3-kinase activation in peripheral blood mononuclear leucocytes from patients with Alzheimer's disease. (17986027)
2007
27
Fas antigen and sporadic Alzheimer's disease in Southern Italy: evaluation of two polymorphisms in the TNFRSF6 gene. (17406980)
2007
28
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease. (17426120)
2007
29
Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. (18057561)
2007
30
Cognitive changes in the preclinical phase of familial Alzheimer's disease. (17852592)
2007
31
A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease. (17240059)
2007
32
Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of AD. (15895300)
2006
33
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
34
The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients. (16445950)
2006
35
Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease. (16990077)
2006
36
Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer's disease brain. (15721223)
2005
37
A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. (14746899)
2004
38
HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease. (12967056)
2003
39
Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study. (12946561)
2003
40
Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease. (12424753)
2003
41
Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. (12218659)
2002
42
Negative symptoms, depression and Alzheimer's disease. (11994894)
2002
43
Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain. (10672313)
2000
44
Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease. (9886083)
1999
45
Unraveling the molecular pathway of Alzheimer's disease: research about presenilins gathers momentum. (9154244)
1996
46
Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative. (7485228)
1995
47
Heterogeneity of tau proteins in Alzheimer's disease. Evidence for increased expression of an isoform and preferential distribution of a phosphorylated isoform in neurites. (7679548)
1993
48
Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. (8497185)
1993
49
Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease. (1915258)
1991
50
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. (1944558)
1991

Variations for Alzheimer's Disease

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UniProtKB/Swiss-Prot genetic disease variations for Alzheimer's Disease:

64 (show all 13)
id Symbol AA change Variation ID SNP ID
1APPp.Ala692GlyVAR_000016
2APPp.Ala713ThrVAR_000019
3APPp.Ile716ValVAR_000020
4APPp.Val717IleVAR_000021
5APPp.Val717GlyVAR_000022
6APPp.Val717PheVAR_000023
7APPp.Val715MetVAR_010108
8APPp.Leu723ProVAR_010109
9APPp.Glu693GlyVAR_014215
10APPp.Thr714IleVAR_014218
11APPp.Val717LeuVAR_014219
12APPp.Thr714AlaVAR_032277
13APPp.Asp678AsnVAR_044424

Clinvar genetic disease variations for Alzheimer's Disease:

6
id Gene Name Type Significance SNP ID Assembly Location
1APPNM_000484.3(APP): c.2149G> A (p.Val717Ile)single nucleotide variantPathogenicrs63750264GRCh37Chr 21, 27264096: 27264096
2APPNM_000484.3(APP): c.2075C> G (p.Ala692Gly)single nucleotide variantPathogenicrs63750671GRCh37Chr 21, 27264170: 27264170
3APPNM_000484.3(APP): c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu)indelPathogenicrs281865161GRCh37Chr 21, 27269938: 27269939
4APPNM_000484.3(APP): c.2078A> G (p.Glu693Gly)single nucleotide variantPathogenicrs63751039GRCh37Chr 21, 27264167: 27264167
5APPNM_000484.3(APP): c.2018C> T (p.Ala673Val)single nucleotide variantPathogenicrs193922916GRCh37Chr 21, 27269931: 27269931
6HFENM_000410.3(HFE): c.845G> A (p.Cys282Tyr)single nucleotide variantPathogenic, confers sensitivity, risk factorrs1800562GRCh37Chr 6, 26093141: 26093141
7MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Alzheimer's Disease

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Expression patterns in normal tissues for genes affiliated with Alzheimer's Disease

Search GEO for disease gene expression data for Alzheimer's Disease.

Pathways for genes affiliated with Alzheimer's Disease

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Pathways related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6GSK3B, A2M, PSEN2, APP, APOE, PSEN1
210.6PSEN1, APP, PSEN2, ACE, CTSD
3
Show member pathways
Alzheimers Disease37
10.6APOE, PSEN1, PSEN2, GSK3B, APP
410.6PSEN1, GSK3B, PSEN2, APOE, APP
510.6A2M, ACE, APP, APOE
6
Show member pathways
10.6CTSD, COL25A1, PSEN1, A2M
710.6APP, PSEN1, GSK3B, PSEN2
8
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
10.6GSK3B, APP, PSEN2, PSEN1
9
Show member pathways
10.6PSEN1, PSEN2, PLD3, GSK3B
1010.6GSK3B, APP, APOE
1110.6PSEN2, GSK3B, PSEN1
1210.6CTSD, PSEN2, GSK3B
13
Show member pathways
Vitamin B12 Metabolism37
10.5MPO, APOE
1410.5PSEN2, PSEN1

Compounds for genes affiliated with Alzheimer's Disease

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Compounds related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1cholesterol44 28 24 1114.2A2M, APP, APOE, PSEN2, ACE, HFE
2serine4411.1APOE, APP, MPO, CTSD, PSEN2, A2M
3valine4411.1PSEN2, PSEN1, MPO, APOE, APP, CTSD
4aspartate4411.1APOE, APP, PSEN1, PSEN2, HFE, CTSD
5h2o24411.1APOE, APP, MPO, PSEN1, PSEN2, CTSD
6alanine4411.0APOE, APP, HFE, PSEN1, CTSD, GSK3B
7bleomycin44 1112.0PSEN1, APOE, BLMH, CTSD
84-hydroxynonenal44 2412.0APOE, APP, MPO, PSEN1
9lactacystin4411.0PSEN2, PSEN1, APP, APOE
10cysteine4411.0APP, BLMH, APOE, PSEN1, HFE, CTSD
11creatinine4411.0APOE, APP, MPO, ACE, CTSD
12heparin44 28 24 1114.0CTSD, A2M, MPO, APP, APOE
13choline44 24 1113.0PSEN2, APP, PSEN1, PLD3
14cysteamine44 24 1113.0MPO, APOE, CTSD
15testosterone44 61 24 1114.0HFE, APOE, CTSD, APP, GSK3B
16s-1824411.0PSEN1, PSEN2
17ab-424411.0PSEN2, APP
18lipid4411.0HFE, GSK3B, APOE, APP, PSEN1, ACE
19l-685,4586111.0PSEN1, PSEN2
20dapt6110.9PSEN1, PSEN2
21ascorbic acid44 2411.9MPO, HFE, CTSD, APOE
22begacestat6110.9PSEN2, PSEN1
23kininogen4410.9MPO, ACE, APP
24jlk 66110.9PSEN2, PSEN1
25mrk 5606110.9PSEN1, PSEN2
26acetylcholine44 50 28 24 1114.9ACE, APOE, APP, MPO
27vitamin b124410.9PSEN1, MPO, APOE
28thioflavine s4410.9APP, APOE
29dihydralazine4410.9MPO, ACE
30metrifonate4410.9APP, APOE
31vegf4410.9CTSD, APOE, APP, MPO, PSEN2
32chloroquine44 2 50 28 1114.9APP, CTSD, APOE
3324s-hydroxy-cholesterol4410.9APP, APOE
34thioflavin t4410.9APP, APOE
35biotin44 24 1112.9PSEN1, APOE, PSEN2
36tacrine44 1111.9APOE, APP
37potassium44 24 1112.8PSEN1, PSEN2, GSK3B, ACE
38nitric oxide44 24 1112.8PSEN1, CTSD, PSEN2, MPO, ACE
39methionine sulfoxide44 24 1112.8MPO, APP
40paraffin4410.8APOE, CTSD, PSEN2, MPO
41donepezil44 50 24 1113.8APOE, APP
42sele4410.8APOE, ACE
43glutamate4410.8APOE, PSEN1, PSEN2, CTSD, APP
44sodium azide4410.7MPO, APP
45glutamine4410.7CTSD, PSEN1, APP, APOE
46thermolysin4410.6CTSD, A2M
47lysine4410.6PSEN1, PSEN2, A2M, CTSD
48hydralazine44 50 1112.5MPO, ACE
49thiorphan44 28 1112.4ACE, APP
50lactate4410.3PSEN2, BLMH, CTSD, MPO

GO Terms for genes affiliated with Alzheimer's Disease

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Cellular components related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:07006210.9APOE, BLMH, APP, MPO, ACE, PLD3
2dendritic shaftGO:04319810.8PSEN1, PSEN2, GSK3B, APP
3ciliary rootletGO:03525310.8PSEN2, PSEN1, APP
4perinuclear region of cytoplasmGO:04847110.8GSK3B, APP, PSEN1, PSEN2, HFE
5neuromuscular junctionGO:03159410.8PSEN1, APP, PSEN2
6integral component of plasma membraneGO:00588710.8HLA-H, COL25A1, HFE, APP, PSEN1, PSEN2
7neuronal cell bodyGO:04302510.7APOE, PSEN1, PSEN2, GSK3B
8growth coneGO:03042610.6PSEN1, PSEN2, GSK3B
9axonGO:03042410.6APP, PSEN1, PSEN2
10extracellular regionGO:00557610.5A2M, COL25A1, ACE, APP, CTSD, APOE
11MHC class I protein complexGO:04261210.5HLA-H, HFE
12membrane raftGO:04512110.3PSEN1, PSEN2, GSK3B

Biological processes related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.0APP, PSEN1, COL25A1, A2M, CTSD
2extracellular matrix disassemblyGO:02261711.0CTSD, A2M, COL25A1, PSEN1
3positive regulation of coagulationGO:05082010.9PSEN2, PSEN1
4smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.9PSEN1, APP
5myeloid leukocyte differentiationGO:00257310.9PSEN2, PSEN1
6response to oxidative stressGO:00697910.9APP, MPO, PSEN1
7regulation of epidermal growth factor-activated receptor activityGO:00717610.9APP, PSEN2
8endoplasmic reticulum calcium ion homeostasisGO:03246910.9PSEN2, PSEN1
9amyloid precursor protein catabolic processGO:04298710.9PSEN2, PSEN1
10antigen processing and presentation of peptide antigen via MHC class IGO:00247410.9HLA-H, BLMH, HFE
11beta-amyloid metabolic processGO:05043510.9PSEN2, PSEN1
12low-density lipoprotein particle remodelingGO:03437410.8MPO, APOE
13anagenGO:04264010.8PSEN2, PSEN1
14negative regulation of protein complex assemblyGO:03133310.8GSK3B, PSEN2
15regulation of neuronal synaptic plasticityGO:04816810.8GSK3B, APOE
16dorsal/ventral neural tube patterningGO:02190410.8PSEN1, PSEN2
17brain morphogenesisGO:04885410.8PSEN1, PSEN2
18hematopoietic progenitor cell differentiationGO:00224410.8PSEN1, PSEN2
19Notch signaling pathwayGO:00721910.7APP, PSEN1, PSEN2
20cell fate specificationGO:00170810.7PSEN1, PSEN2
21regulation of protein bindingGO:04339310.7PSEN1, APP
22T cell activation involved in immune responseGO:00228610.6PSEN2, PSEN1
23membrane protein ectodomain proteolysisGO:00650910.6PSEN1, PSEN2
24positive regulation of T cell mediated cytotoxicityGO:00191610.5HLA-H, HFE
25protein processingGO:01648510.5PSEN2, PSEN1
26Notch receptor processingGO:00722010.4PSEN2, PSEN1
27autophagic vacuole assemblyGO:00004510.2CTSD, PSEN1

Molecular functions related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8BLMH, APOE, APP, PSEN1, PSEN2, ACE
2aspartic-type endopeptidase activityGO:00419010.7CTSD, PSEN2, PSEN1
3endopeptidase activityGO:00417510.7ACE, PSEN2, PSEN1
4heparin bindingGO:00820110.7APOE, APP, MPO, COL25A1
5tau protein bindingGO:04815610.6GSK3B, APOE
6peptide antigen bindingGO:04260510.5HFE, HLA-H
7carboxypeptidase activityGO:00418010.4BLMH, ACE
8beta-amyloid bindingGO:00154010.2COL25A1, APOE

Products for genes affiliated with Alzheimer's Disease

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Sources for Alzheimer's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet