AD
MCID: ALZ001
MIFTS: 97

Alzheimer's Disease (AD) malady

Genetic diseases, Rare diseases, Mental diseases, Neuronal diseases categories

Summaries for Alzheimer's Disease

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Sources:
9Disease Ontology, 22Genetics Home Reference, 44NIH Rare Diseases, 35MedlinePlus, 4CDC, 45NINDS, 47Novus Biologicals, 66Wikipedia, 48OMIM, 20GeneReviews, 34MalaCards
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MedlinePlus:35 Alzheimer's disease (ad) is the most common form of dementia among older people. dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. ad begins slowly. it first involves the parts of the brain that control thought, memory and language. people with ad may have trouble remembering things that happened recently or names of people they know. a related problem, mild cognitive impairment (mci), causes more memory problems than normal for people of the same age. many, but not all, people with mci will develop ad. in ad, over time, symptoms get worse. people may not recognize family members or have trouble speaking, reading or writing. they may forget how to brush their teeth or comb their hair. later on, they may become anxious or aggressive, or wander away from home. eventually, they need total care. this can cause great stress for family members who must care for them. ad usually begins after age 60. the risk goes up as you get older. your risk is also higher if a family member has had the disease. no treatment can stop the disease. however, some drugs may help keep symptoms from getting worse for a limited time. nih: national institute on aging

MalaCards: Alzheimer's Disease, also known as alzheimer disease, is related to dementia and alzheimer disease type 2. An important gene associated with Alzheimer's Disease is A2M (alpha-2-macroglobulin), and among its related pathways are Alzheimers Disease Pathway and A-beta Plaque Formation and APP Metabolism. The drugs galantamine and selegiline and the compounds cholesterol and serine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are immune system and behavior/neurological.

Disease Ontology:9 A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. it is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

Genetics Home Reference:22 Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.

NIH Rare Diseases:44 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

CDC:4 Alzheimer’s disease is the most common form of dementia among older adults. Alzheimer’s disease involves parts of the brain that control thought, memory, and language and can seriously affect a person’s ability to carry out daily activities. Although scientists are learning more every day, right now, they still do not know what causes Alzheimer’s disease.

NINDS:45 Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.

Novus Biologicals:47 Alzheimer's Disease (AD) is the most common form of dementia that affects 5.3 million Americans. AD causes the damage and destruction of nerves in the brain. Hallmark abnormalities include deposits of beta-amyloid (plaques) and twisted strands of tau (tangles). Beta-amyloid peptide, a protein derived from amyloid precursor protein (APP), aggregates into a beta-pleated sheet configuration which is neurotoxic and forms the core of neuritic plaques. These abnormalities disrupt cellular communication, cause damage via oxidative metabolism, initiate abnormal accumulation of cytoskeletal proteins and result in cell death. Genes identified as causing susceptibility to Alzheimer's disease do not singly cause the disease state, but when combined with other epigenetic and environmental factors can lead to the condition.

Wikipedia:66 Alzheimer\'s disease (AD), also known in medical literature as Alzheimer disease, is the most common... more...

Description from OMIM:48 611152, 609790, 300756, 611154, 608907 609636, 607822, 104310, 602096, 607116, 611155, 104300, 606187, 605526, 615080, 606889, 611073 more

GeneReviews summary for alzheimer

Aliases & Classifications for Alzheimer's Disease

About this section
Sources:
9Disease Ontology, 66Wikipedia, 22Genetics Home Reference, 45NINDS, 35MedlinePlus, 32LifeMap Discovery™, 63UMLS, 20GeneReviews, 44NIH Rare Diseases, 21GeneTests, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

alzheimer's disease 9 66 22 45 35 32 63
alzheimer disease 9 20 44 21 23 22 48
familial alzheimer disease 66 44 22
ad 9 66 22
primary senile degenerative dementia 66 22
presenile and senile dementia 66 22
alzheimers disease 11 46
sdat 66 22
dementia of the alzheimer's type 9
dat - dementia alzheimer's type 66
dementia in alzheimer's disease 9
alzheimer disease, familial 63
alzheimer disease familial 44
alzheimer-type dementia 22
alzheimers dementia 9
alzheimer sclerosis 22
alzheimer dementia 22
alzheimer syndrome 22
alstrom syndrome 63
dat 22
fad 44


Related Diseases for Alzheimer's Disease

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Alzheimer's Disease family:

Alzheimer Disease Type 1 Alzheimer Disease Type 2
Alzheimer Disease Type 3 Alzheimer Disease Type 4
Alzheimer Disease Type 5 Alzheimer Disease-13
Alzheimer Disease-14 Alzheimer Disease-15
Alzheimer Disease 17 Alzheimer Disease-10
Alzheimer Disease 12 Alzheimer Disease-11
Alzheimer Disease-7 Alzheimer Disease 6
Alzheimer Disease 18 Alzheimer Disease 9, Late Onset
Alzheimer Disease 19, Late Onset Alzheimer Disease 8
Alzheimer Disease 1, Familial Alzheimer Disease 16

Diseases related to Alzheimer's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 471)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.5BLMH, APOE, APP, PSEN1, PSEN2, GSK3B
2alzheimer disease type 231.3APOE, APP, PSEN1, PSEN2, GSK3B, CTSD
3alzheimer disease type 131.0PSEN2, PSEN1, APP
4cerebral amyloid angiopathy31.0PSEN1, APP, APOE
5down syndrome31.0PSEN2, PSEN1, APP, APOE
6vascular dementia30.8APOE, APP, PSEN1
7tauopathy30.7PSEN1, APP
8cerebrovascular disease30.7APOE, APP, ACE
9amyloidosis30.6APOE, APP, PSEN1, PSEN2, CTSD
10lewy body dementia30.5APOE, APP
11memory impairment30.5APOE, APP, PSEN1
12amyotrophic lateral sclerosis30.5PSEN1, APP
13progressive supranuclear palsy30.5APOE, APP
14alzheimer disease 630.4AD6
15inclusion body myositis30.4APP
16coronary artery disease30.4HFE, ACE, APOE
17frontotemporal dementia30.4APOE, APP, PSEN1, PSEN2
18pick's disease30.3APOE, APP, PSEN1
19prion disease30.3APP, PSEN1, PSEN2
20bipolar disorder30.2GSK3B, PSEN2
21parkinson's disease30.0APOE, APP, PSEN1, GSK3B
22age related macular degeneration30.0APOE, CTSD
23creutzfeldt-jakob disease30.0APOE, APP
24diabetic nephropathy29.9APOE, ACE, HFE
25vascular disease29.8ACE, PSEN1, APOE
26hyperlipidemia type 310.8
27cerebritis10.7
28alzheimer disease type 310.5
29alzheimer disease type 410.4
30spastic paraparesis10.3
31spasticity10.3
32blindness10.3
33dermatitis10.3
34atopic dermatitis10.2
35leukemia10.2
36hypercholesterolemia10.2
37tardive dyskinesia10.2
38breast cancer10.2
39normal pressure hydrocephalus10.2
40apraxia10.2
41hydrocephalus10.2
42multiple sclerosis10.2
43cerebral atrophy10.2
44adenocarcinoma10.2
45hepatitis10.2
46melanoma10.2
47autosomal dominant hyper ige syndrome10.2
48cushing's syndrome10.2
49lactic acidosis10.2
50mitochondrial encephalomyopathy10.2

Graphical network of the top 20 diseases related to Alzheimer's Disease:



Diseases related to alzheimer's disease

Symptoms for Alzheimer's Disease

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48OMIM
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Drugs & Therapeutics for Alzheimer's Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discovery™, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alzheimer's Disease

Drug clinical trials:

Search ClinicalTrials for Alzheimer's Disease

Search NIH Clinical Center for Alzheimer's Disease

Search CenterWatch for Alzheimer's Disease

Inferred drug relations via UMLS63/NDF-RT42:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Alzheimer's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alzheimer's Disease:
NEUROSTEM
Embryonic/Adult Cultured Cells Related to Alzheimer's Disease:
Umbilical cord blood-derived mesenchymal stem/progenitor cells , PMIDs: 23293711, 22015609

Genetic Tests for Alzheimer's Disease

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21GeneTests, 23GTR
See all sources

Genetic tests related to Alzheimer's Disease:

id Genetic test Affiliating Genes
1 Alzheimer Disease21
2 Alzheimer's Disease23

Anatomical Context for Alzheimer's Disease

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Sources:
32LifeMap Discovery™, 34MalaCards
See all sources

MalaCards organs/tissues related to Alzheimer's Disease:

34
Brain, Cortex, Testes, Temporal lobe, Endothelial, Amygdala, Monocytes, Liver, Cerebellum, Heart, Prefrontal cortex, T cells, Skin, Hypothalamus, Smooth muscle, Thyroid, Eye, Thalamus, Occipital lobe, Breast, Placenta, Retina, Adrenal cortex, Cingulate cortex, Caudate nucleus, Olfactory bulb, Pituitary, Pineal, Prostate, Adrenal gland, Myeloid, Kidney, Spinal cord, Subthalamic nucleus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alzheimer's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
3 BrainHippocampus  Affected by disease

Animal Models for Alzheimer's Disease or affiliated genes

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Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Alzheimer's Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.9CTSD, BLMH, APOE, APP, MPO, PSEN1
2MP:000538610.9BLMH, APOE, APP, PSEN1, PSEN2, ACE
3MP:000537610.9BLMH, APOE, APP, MPO, PSEN1, PSEN2
4MP:001076810.8MPO, APP, APOE, BLMH, PSEN1, PSEN2
5MP:000537810.7BLMH, APOE, APP, PSEN1, PSEN2, ACE
6MP:000538110.6APOE, PSEN1, PSEN2, HFE, GSK3B, CTSD
7MP:000537910.6CTSD, GSK3B, ACE, PSEN2, PSEN1, APOE
8MP:000537110.5BLMH, APOE, PSEN1, PSEN2, HFE
9MP:000538510.3BLMH, APOE, MPO, PSEN1, PSEN2, ACE

Publications for Alzheimer's Disease

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Sources:
53PubMed
See all sources

Articles related to Alzheimer's Disease:

(show top 50)    (show all 6623)
idTitleAuthorsYear
1
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. (24252572)
2013
2
Screening of microRNAs associated with Alzheimer's disease using oxidative stress cell model and different strains of senescence accelerated mice. (24423585)
2013
3
AI^38 in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models. (24305500)
2013
4
No diagnostic value of plasma clusterin in Alzheimer's disease. (23209684)
2012
5
Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. (22349685)
2012
6
Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes. (22580620)
2012
7
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
8
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. (22926141)
2012
9
Apolipoprotein E I/4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis. (21124030)
2011
10
Cerebrospinal fluid profile of amyloid I^42 (AI^42), hTau and ubiquitin in North Indian Alzheimer's disease patients. (20599474)
2011
11
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
12
Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment. (19836440)
2010
13
Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease. (19897004)
2010
14
Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex. (21034788)
2010
15
Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. (20025970)
2010
16
Efficient processing of Alzheimer's disease amyloid-Beta peptides by neuroectodermally converted mesenchymal stem cells. (19469700)
2010
17
Clinical features of rapidly progressive Alzheimer's disease. (20453509)
2010
18
Critical evaluation of self-rated quality of life in mild cognitive impairment and Alzheimer's disease--further evidence for the impact of anosognosia and global cognitive impairment. (19262958)
2009
19
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. (19374444)
2009
20
An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. (19016491)
2009
21
Impact of rivastigmine on caregiver burden associated with Alzheimer's disease in both informal care and nursing home settings. (18582146)
2008
22
Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. (18363936)
2008
23
Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet? (18327642)
2008
24
Reduced insulin-induced phosphatidylinositol-3-kinase activation in peripheral blood mononuclear leucocytes from patients with Alzheimer's disease. (17986027)
2007
25
Fas antigen and sporadic Alzheimer's disease in Southern Italy: evaluation of two polymorphisms in the TNFRSF6 gene. (17406980)
2007
26
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease. (17426120)
2007
27
Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. (18057561)
2007
28
Cognitive changes in the preclinical phase of familial Alzheimer's disease. (17852592)
2007
29
A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease. (17240059)
2007
30
Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of AD. (15895300)
2006
31
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
32
The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients. (16445950)
2006
33
Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease. (16990077)
2006
34
Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer's disease brain. (15721223)
2005
35
A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. (14746899)
2004
36
HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease. (12967056)
2003
37
Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study. (12946561)
2003
38
Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease. (12424753)
2003
39
Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. (12218659)
2002
40
Negative symptoms, depression and Alzheimer's disease. (11994894)
2002
41
Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain. (10672313)
2000
42
Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease. (9886083)
1999
43
Unraveling the molecular pathway of Alzheimer's disease: research about presenilins gathers momentum. (9154244)
1996
44
Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative. (7485228)
1995
45
Preservation of kappa 1 opioid receptor recognition site density and regulation by G-proteins in the temporal cortex of patients with Alzheimer's disease. (7746504)
1995
46
Heterogeneity of tau proteins in Alzheimer's disease. Evidence for increased expression of an isoform and preferential distribution of a phosphorylated isoform in neurites. (7679548)
1993
47
Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. (8497185)
1993
48
The role of perivascular and microglial cells in fibrillogenesis of beta-amyloid and PrP protein in Alzheimer's disease and scrapie. (1455056)
1992
49
Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease. (1915258)
1991
50
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. (1944558)
1991

Variations for Alzheimer's Disease

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Alzheimer's Disease:

65 (show all 13)
id Symbol AA change Variation ID SNP ID
1APPp.Ala692GlyVAR_000016
2APPp.Ala713ThrVAR_000019
3APPp.Ile716ValVAR_000020
4APPp.Val717IleVAR_000021
5APPp.Val717GlyVAR_000022
6APPp.Val717PheVAR_000023
7APPp.Val715MetVAR_010108
8APPp.Leu723ProVAR_010109
9APPp.Glu693GlyVAR_014215
10APPp.Thr714IleVAR_014218
11APPp.Val717LeuVAR_014219
12APPp.Thr714AlaVAR_032277
13APPp.Asp678AsnVAR_044424

Clinvar genetic disease variations for Alzheimer's Disease:

1 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1APPNM_000484.3(APP): c.2149G> A (p.Val717Ile)single nucleotide variantPathogenicrs63750264GRCh37Chr 21, 27264096: 27264096
2APPNM_000484.3(APP): c.2075C> G (p.Ala692Gly)single nucleotide variantPathogenicrs63750671GRCh37Chr 21, 27264170: 27264170
3APPNM_000484.3(APP): c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu)indelPathogenicrs281865161GRCh37Chr 21, 27269938: 27269939
4APPNM_000484.3(APP): c.2078A> G (p.Glu693Gly)single nucleotide variantPathogenicrs63751039GRCh37Chr 21, 27264167: 27264167
5APPNM_000484.3(APP): c.2018C> T (p.Ala673Val)single nucleotide variantPathogenicrs193922916GRCh37Chr 21, 27269931: 27269931
6ALMS1NM_015120.4(ALMS1): c.8383C> T (p.Gln2795Ter)single nucleotide variantPathogenicrs193919338GRCh37Chr 2, 73717466: 73717466
7ALMS1NM_015120.4(ALMS1): c.10775delC (p.Thr3592Lysfs)deletionPathogenicrs387906312GRCh37Chr 2, 73799776: 73799776
8ALMS1NM_015120.4(ALMS1): c.2141_2142delCT (p.Ser714Tyrfs)deletionPathogenicrs387906313GRCh37Chr 2, 73675792: 73675793
9ALMS1NM_015120.4(ALMS1): c.10992G> A (p.Trp3664Ter)single nucleotide variantPathogenicrs193919339GRCh37Chr 2, 73799993: 73799993
10ALMS1NM_015120.4(ALMS1): c.10945G> T (p.Glu3649Ter)single nucleotide variantPathogenicrs397514576GRCh37Chr 2, 73799946: 73799946
11ALMS1NM_015120.4(ALMS1): c.8164C> T (p.Arg2722Ter)single nucleotide variantPathogenicrs193919340GRCh37Chr 2, 73717247: 73717247
12HFENM_000410.3(HFE): c.845G> A (p.Cys282Tyr)single nucleotide variantBenign, Pathogenic, association, confers sensitivity, risk factorrs1800562GRCh37Chr 6, 26093141: 26093141
13MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Alzheimer's Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alzheimer's Disease

Search GEO for disease gene expression data for Alzheimer's Disease.

Pathways for genes affiliated with Alzheimer's Disease

About this section
Sources:
51PathCards, 54QIAGEN, 55R&D Systems, 5Cell Signaling Technology, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 62Tocris Bioscience
See all sources

Pathways related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6GSK3B, A2M, PSEN2, PSEN1, APP, APOE
210.6APP, PSEN1, PSEN2, ACE, CTSD
310.6APOE, APP, PSEN1, PSEN2, GSK3B
4
Show member pathways
Alzheimers Disease39
10.6GSK3B, PSEN2, PSEN1, APP, APOE
510.6APOE, APP, ACE, A2M
6
Show member pathways
10.6PSEN1, COL25A1, A2M, CTSD
7
Show member pathways
Delta-Notch Signaling Pathway39
Notch Signaling Pathway39
10.6APP, PSEN1, PSEN2, GSK3B
810.6GSK3B, PSEN2, PSEN1, APP
9
Show member pathways
10.6PSEN1, PSEN2, PLD3, GSK3B
1010.5GSK3B, PSEN2, PSEN1
1110.5GSK3B, APP, APOE
1210.5PSEN2, GSK3B, CTSD
13
Show member pathways
Vitamin B12 Metabolism39
10.5MPO, APOE
1410.5PSEN2, PSEN1

Compounds for genes affiliated with Alzheimer's Disease

About this section
Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 3BitterDB
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Compounds related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1cholesterol46 30 25 1214.1APOE, APP, PSEN1, PSEN2, ACE, HFE
2serine4611.1APOE, APP, MPO, PSEN1, PSEN2, A2M
3valine4611.1CTSD, APOE, APP, MPO, PSEN1, PSEN2
4aspartate4611.1APOE, APP, PSEN1, PSEN2, HFE, CTSD
5h2o24611.0APOE, APP, MPO, PSEN1, PSEN2, CTSD
6bleomycin46 1212.0BLMH, APOE, PSEN1, CTSD
7alanine4611.0APOE, APP, PSEN1, HFE, GSK3B, CTSD
84-hydroxynonenal46 2512.0APOE, APP, MPO, PSEN1
9lactacystin4611.0APOE, APP, PSEN1, PSEN2
10creatinine4611.0APOE, APP, MPO, ACE, CTSD
11heparin46 30 25 1214.0APOE, APP, MPO, A2M, CTSD
12cysteine4611.0BLMH, APOE, APP, PSEN1, HFE, CTSD
13choline46 25 1213.0APP, PSEN1, PSEN2, PLD3
14cysteamine46 25 1213.0CTSD, MPO, APOE
15ab-424611.0APP, PSEN2
16s-1824610.9PSEN1, PSEN2
17mrk 5606210.9PSEN1, PSEN2
18jlk 66210.9PSEN1, PSEN2
19testosterone46 62 25 1213.9APOE, APP, HFE, GSK3B, CTSD
20begacestat6210.9PSEN1, PSEN2
21l-685,4586210.9PSEN1, PSEN2
22dapt6210.9PSEN1, PSEN2
23kininogen4610.9APP, MPO, ACE
24lipid4610.9APOE, APP, PSEN1, ACE, HFE, GSK3B
25ascorbic acid46 2511.9CTSD, HFE, MPO, APOE
26thioflavine s4610.9APP, APOE
27vitamin b124610.9PSEN1, MPO, APOE
28dihydralazine4610.9ACE, MPO
29metrifonate4610.9APP, APOE
30acetylcholine46 52 30 25 1214.9ACE, MPO, APP, APOE
31chloroquine46 3 52 30 1214.9APOE, APP, CTSD
3224s-hydroxy-cholesterol4610.9APOE, APP
33vegf4610.9APOE, APP, MPO, PSEN2, CTSD
34thioflavin t4610.8APOE, APP
35biotin46 25 1212.8PSEN2, PSEN1, APOE
36tacrine46 1211.8APP, APOE
37potassium46 25 1212.8PSEN1, PSEN2, ACE, GSK3B
38methionine sulfoxide46 25 1212.8MPO, APP
39nitric oxide46 25 1212.8MPO, PSEN1, PSEN2, ACE, CTSD
40donepezil46 52 25 1213.8APP, APOE
41paraffin4610.8APOE, MPO, PSEN2, CTSD
42sele4610.8ACE, APOE
43glutamate4610.7APOE, APP, PSEN1, PSEN2, CTSD
44sodium azide4610.7MPO, APP
45glutamine4610.7APOE, APP, PSEN1, CTSD
46thermolysin4610.6CTSD, A2M
47lysine4610.6PSEN1, PSEN2, A2M, CTSD
48hydralazine46 52 1212.5ACE, MPO
49thiorphan46 30 1212.4ACE, APP
50lactate4610.3BLMH, MPO, PSEN2, CTSD

GO Terms for genes affiliated with Alzheimer's Disease

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Sources:
17Gene Ontology
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Cellular components related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:07006210.9BLMH, APOE, APP, MPO, ACE, PLD3
2dendritic shaftGO:04319810.8GSK3B, PSEN2, PSEN1, APP
3ciliary rootletGO:03525310.8APP, PSEN1, PSEN2
4perinuclear region of cytoplasmGO:04847110.8APP, PSEN1, PSEN2, HFE, GSK3B
5neuromuscular junctionGO:03159410.7PSEN2, PSEN1, APP
6integral component of plasma membraneGO:00588710.7HLA-H, APP, PSEN1, PSEN2, COL25A1, HFE
7neuronal cell bodyGO:04302510.7APOE, PSEN1, PSEN2, GSK3B
8growth coneGO:03042610.6GSK3B, PSEN2, PSEN1
9axonGO:03042410.5PSEN2, PSEN1, APP
10MHC class I protein complexGO:04261210.5HLA-H, HFE
11extracellular regionGO:00557610.5APOE, APP, ACE, COL25A1, A2M, CTSD
12membrane raftGO:04512110.2GSK3B, PSEN2, PSEN1

Biological processes related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.0APP, PSEN1, COL25A1, A2M, CTSD
2extracellular matrix disassemblyGO:02261710.9CTSD, A2M, COL25A1, PSEN1
3positive regulation of coagulationGO:05082010.9PSEN2, PSEN1
4smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.9PSEN1, APP
5myeloid leukocyte differentiationGO:00257310.9PSEN2, PSEN1
6regulation of epidermal growth factor-activated receptor activityGO:00717610.9APP, PSEN2
7response to oxidative stressGO:00697910.9APP, MPO, PSEN1
8endoplasmic reticulum calcium ion homeostasisGO:03246910.9PSEN2, PSEN1
9amyloid precursor protein catabolic processGO:04298710.9PSEN2, PSEN1
10beta-amyloid metabolic processGO:05043510.8PSEN2, PSEN1
11antigen processing and presentation of peptide antigen via MHC class IGO:00247410.8HLA-H, BLMH, HFE
12low-density lipoprotein particle remodelingGO:03437410.8MPO, APOE
13anagenGO:04264010.8PSEN2, PSEN1
14negative regulation of protein complex assemblyGO:03133310.8GSK3B, PSEN2
15regulation of neuronal synaptic plasticityGO:04816810.8GSK3B, APOE
16dorsal/ventral neural tube patterningGO:02190410.8PSEN1, PSEN2
17brain morphogenesisGO:04885410.8PSEN1, PSEN2
18hematopoietic progenitor cell differentiationGO:00224410.7PSEN1, PSEN2
19cell fate specificationGO:00170810.7PSEN1, PSEN2
20Notch signaling pathwayGO:00721910.7APP, PSEN1, PSEN2
21regulation of protein bindingGO:04339310.7PSEN1, APP
22T cell activation involved in immune responseGO:00228610.6PSEN2, PSEN1
23membrane protein ectodomain proteolysisGO:00650910.6PSEN1, PSEN2
24positive regulation of T cell mediated cytotoxicityGO:00191610.5HLA-H, HFE
25protein processingGO:01648510.5PSEN2, PSEN1
26Notch receptor processingGO:00722010.4PSEN2, PSEN1
27autophagic vacuole assemblyGO:00004510.2CTSD, PSEN1

Molecular functions related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.7BLMH, APOE, APP, PSEN1, PSEN2, ACE
2aspartic-type endopeptidase activityGO:00419010.7CTSD, PSEN2, PSEN1
3endopeptidase activityGO:00417510.7ACE, PSEN2, PSEN1
4heparin bindingGO:00820110.7APOE, APP, MPO, COL25A1
5tau protein bindingGO:04815610.6GSK3B, APOE
6peptide antigen bindingGO:04260510.5HFE, HLA-H
7carboxypeptidase activityGO:00418010.4BLMH, ACE
8beta-amyloid bindingGO:00154010.2COL25A1, APOE

Products for genes affiliated with Alzheimer's Disease

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Sources for Alzheimer's Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet