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MCID: ALZ001
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Alzheimer's Disease malady |
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20 drugs, 1854 genes, 38 tissues, 1049 related diseases, 29 phenotypes, 5592 articles, clinical trials, genetic tests.
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Sources: 6Disease Ontology, 23MedlinePlus, 2CDC, 15GeneReviews, 17Genetics Home Reference, 44Wikipedia, 33OMIM, 22MalaCards See all sources Export this MalaCard |
MedlinePlus: Alzheimer's disease (ad) is the most common form of dementia among older people. dementia is a brain disorder that seriously affects a person's ability to carry out daily activities.
ad begins slowly. it first involves the parts of the brain that control thought, memory and language. people with ad may have trouble remembering things that happened recently or names of people they know. a related problem, mild cognitive impairment (mci), causes more memory problems than normal for people of the same age. many, but not all, people with mci will develop ad.
in ad, over time, symptoms get worse. people may not recognize family members or have trouble speaking, reading or writing. they may forget how to brush their teeth or comb their hair. later on, they may become anxious or aggressive, or wander away from home. eventually, they need total care. this can cause great stress for family members who must care for them.
ad usually begins after age 60. the risk goes up as you get older. your risk is also higher if a family member has had the disease.
no treatment can stop the disease. however, some drugs may help keep symptoms from getting worse for a limited time.
nih: national institute on aging23
MalaCards: Alzheimer's Disease, also known as alzheimer disease, is related to neuronitis and carcinoma. An important gene associated with Alzheimer's Disease is APP (amyloid beta (A4) precursor protein), and among its related pathways are Antioxidant Action of Vitamin-C and MAPK Family Pathway. The drugs citalopram hydrobromide and galantamine hydrobromide and the compounds serine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are homeostasis/metabolism and mortality/aging. Disease Ontology: A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. it is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.6 CDC: Alzheimer’s disease is the most common form of dementia among older adults. Alzheimer’s disease involves parts of the brain that control thought, memory, and language and can seriously affect a person’s ability to carry out daily activities. Although scientists are learning more every day, right now, they still do not know what causes Alzheimer’s disease. 2 NINDS: Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.31 Genetics Home Reference: Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.17 Wikipedia: Alzheimer\'s disease (AD), also known in medical literature as Alzheimer disease, is the most common...44 more... OMIM: 104300 GeneReviews summary for alzheimer |
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Sources: 2CDC, 6Disease Ontology, 44Wikipedia, 17Genetics Home Reference, 31NINDS, 23MedlinePlus, 43UMLS, 7diseasecard, 15GeneReviews, 16GeneTests, 33OMIM, 8DISEASES, 32Novoseek , 27NCIt, 40SNOMED-CT, 24MeSH, 19ICD9CM See all sources |
Aliases & Descriptions:
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Sources: 33OMIM See all sources |
Clinical features from OMIM: 104300
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for alzheimer's disease Drug clinical trials:Search ClinicalTrials for alzheimer's disease Search NIH Clinical Center for alzheimer's disease Search CenterWatch for alzheimer's disease Inferred drug relations via UMLS/NDF-RT:43 28 citalopram, citalopram hydrobromide, divalproex, divalproex sodium, donepezil, donepezil hydrochloride, galantamine, galantamine hydrobromide, prochlorperazine, prochlorperazine edisylate, prochlorperazine maleate, risperidone, rivastigmine, rivastigmine tartrate, selegiline, selegiline hydrochloride, tacrine, tacrine hydrochloride, valproate sodium, valproic acidCell-based therapeutics: The database of embryonic development, stem cell research and regenerative medicine Stem-Cell-Based therapeutic approaches for alzheimer's disease:
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Sources: 16GeneTests See all sources |
Genetic tests related to alzheimer's disease:
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Sources: 21LifeMap Discovery™, 22MalaCards See all sources |
MalaCards organs/tissues related to alzheimer's disease:22Whole blood, Brain, Cortex, Cerebellum, Retina, Spinal cord, Heart, Smooth muscle, Skeletal muscle, Liver, Thyroid, Adrenal gland, Breast, Skin, Placenta, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Prefrontal cortex, Cingulate cortex, Parietal lobe, Temporal lobe, Occipital lobe, Olfactory bulb, Hypothalamus, Caudate nucleus, Amygdala, Pons, Fetal liver, Fetal thyroid, Pancreatic islet, Adrenal cortex, Pineal The database of embryonic development, stem cell research and regenerative medicine Embryonic and adult cells/anatomical compartments related to alzheimer's disease:
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Brain -> |
Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to alzheimer's disease:25 (show all 29)
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Sources: 35PubMed See all sources |
Articles related to alzheimer's disease:(show top 50) (show all 5592)
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Sources: 1BioGPS See all sources |
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Sources: 36QIAGEN, 20KEGG, 3Cell Signaling Technology, 37R&D Systems, 10EMD Millipore, 41Thomson Reuters, 34PharmGKB See all sources |
Pathways related to alzheimer's disease according to GeneDecks:(show top 50) (show all 300)
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Sources: 32Novoseek , 18HMDB, 9DrugBank, 42Tocris Bioscience, 34PharmGKB See all sources |
Compounds related to alzheimer's disease according to GeneDecks:(show top 50) (show all 511)
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Sources: 12Gene Ontology See all sources |
Cellular components related to alzheimer's disease according to GeneDecks:(show all 24)
Biological processes related to alzheimer's disease according to GeneDecks:(show top 50) (show all 71)
Molecular functions related to alzheimer's disease according to GeneDecks:(show all 13)
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