AD
MCID: ALZ001
MIFTS: 98

Alzheimer's Disease (AD) malady

Genetic diseases, Rare diseases, Mental diseases, Neuronal diseases categories

Summaries for Alzheimer's Disease

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MedlinePlus:33 Alzheimer's disease (ad) is the most common form of dementia among older people. dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. ad begins slowly. it first involves the parts of the brain that control thought, memory and language. people with ad may have trouble remembering things that happened recently or names of people they know. a related problem, mild cognitive impairment (mci), causes more memory problems than normal for people of the same age. many, but not all, people with mci will develop ad. in ad, over time, symptoms get worse. people may not recognize family members or have trouble speaking, reading or writing. they may forget how to brush their teeth or comb their hair. later on, they may become anxious or aggressive, or wander away from home. eventually, they need total care. this can cause great stress for family members who must care for them. ad usually begins after age 60. the risk goes up as you get older. your risk is also higher if a family member has had the disease. no treatment can stop the disease. however, some drugs may help keep symptoms from getting worse for a limited time. nih: national institute on aging

MalaCards based summary: Alzheimer's Disease, also known as alzheimer disease, is related to dementia and alzheimer disease type 1. An important gene associated with Alzheimer's Disease is A2M (alpha-2-macroglobulin), and among its related pathways are Alzheimers Disease Pathway and A-beta Plaque Formation and APP Metabolism. The drugs galantamine and selegiline and the compounds cholesterol and serine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:9 A dementia and a tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. it is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

Genetics Home Reference:22 Alzheimer disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.

NIH Rare Diseases:42 Alzheimer disease is a degenerative disease of the brain that causes gradual loss of memory, judgment, and ability to function socially. alzheimer disease currently affects about 5 million people. about 75 percent of alzheimer disease cases are classified as sporadic, which means they occur in people with no history of the disorder in their family. although the cause of these cases is unknown, genetic changes are likely to play a role. virtually all sporadic alzheimer disease begins after age 65, and the risk of developing this condition increases as a person gets older. the remaining cases of alzheimer disease are familial, which means they are found in multiple members of a family. familial alzheimer disease can be divided into early-onset disease (symptoms begin before age 65) and late-onset disease (symptoms begin after age 65). last updated: 7/2/2013

CDC:4 Although scientists are learning more every day, right now, they still do not know what causes AlzheimerÔÇÖs disease.

NINDS:43 Alzheimer's disease (AD) is an age-related, non-reversible brain disorder that develops over a period of years. Initially, people experience memory loss and confusion, which may be mistaken for the kinds of memory changes that are sometimes associated with normal aging. However, the symptoms of AD gradually lead to behavior and personality changes, a decline in cognitive abilities such as decision-making and language skills, and problems recognizing family and friends. AD ultimately leads to a severe loss of mental function. These losses are related to the worsening breakdown of the connections between certain neurons in the brain and their eventual death. AD is one of a group of disorders called that are characterized by cognitive and behavioral problems. It is the most common cause of dementia among people age 65 and older.

Novus Biologicals:45 Alzheimer's Disease (AD) is the most common form of dementia that affects 5.3 million Americans. AD causes the damage and destruction of nerves in the brain. Hallmark abnormalities include deposits of beta-amyloid (plaques) and twisted strands of tau (tangles). Beta-amyloid peptide, a protein derived from amyloid precursor protein (APP), aggregates into a beta-pleated sheet configuration which is neurotoxic and forms the core of neuritic plaques. These abnormalities disrupt cellular communication, cause damage via oxidative metabolism, initiate abnormal accumulation of cytoskeletal proteins and result in cell death. Genes identified as causing susceptibility to Alzheimer's disease do not singly cause the disease state, but when combined with other epigenetic and environmental factors can lead to the condition.

Wikipedia:64 Alzheimer\'s disease (AD), also known as Alzheimer disease, is the most common form of dementia. There... more...

Descriptions from OMIM:46 605526, 104310, 607116, 611154, 607822 611152, 606187, 104300, 606889, 300756, 615080, 611155, 608907, 609636, 609790, 611073, 602096 more

GeneReviews summary for alzheimer

Aliases & Classifications for Alzheimer's Disease

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Alzheimer's Disease, Aliases & Descriptions:

Name: Alzheimer's Disease 31 9 64 22 43 33 61
Alzheimer Disease 9 20 42 21 23 22 46
Primary Senile Degenerative Dementia 64 22 61
Familial Alzheimer Disease 64 42 22
Ad 9 64 22
Presenile and Senile Dementia 64 22
Alzheimers Dementia 9 61
Alzheimer Sclerosis 22 61
Alzheimers Disease 11 44
Alzheimer Syndrome 22 61
Sdat 64 22
 
Dementia of the Alzheimer's Type 9
Dementia in Alzheimer's Disease 9
Dat - Dementia Alzheimer's Type 64
Alzheimer Disease, Familial 61
Alzheimer Disease Familial 42
Dementia, Alzheimer Type 61
Alzheimer-Type Dementia 22
Alzheimer Dementia 22
Fad 42
Dat 22


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases, Neuronal diseases


Related Diseases for Alzheimer's Disease

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Diseases in the Alzheimer's Disease family:

Alzheimer Disease Type 1 Alzheimer Disease Type 2
Alzheimer Disease Type 3 Alzheimer Disease Type 4
Alzheimer Disease Type 5 Alzheimer Disease-13
Alzheimer Disease-14 Alzheimer Disease-15
Alzheimer Disease 17 Alzheimer Disease-10
Alzheimer Disease 12 Alzheimer Disease-11
Alzheimer Disease-7 Alzheimer Disease 6
Alzheimer Disease 18 Alzheimer Disease 9, Late Onset
Alzheimer Disease 19, Late Onset Alzheimer Disease 8
Alzheimer Disease 1, Familial Alzheimer Disease 16

Diseases related to Alzheimer's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 496)
idRelated DiseaseScoreTop Affiliating Genes
1dementia32.3APOE, APP, BLMH, GSK3B, PSEN2, PSEN1
2alzheimer disease type 131.9PSEN2, PSEN1, APP
3vascular dementia31.6PSEN1, APP, APOE
4amyloidosis31.4APOE, CTSD, PSEN2, PSEN1, APP
5frontotemporal dementia31.2APOE, PSEN1, APP, PSEN2
6alzheimer disease 631.1AD6
7progressive supranuclear palsy31.1APOE, APP
8alzheimer disease type 231.1CTSD, GSK3B, PSEN2, PSEN1, APP, APOE
9pick's disease31.1PSEN1, APP, APOE
10memory impairment31.0APOE, APP, PSEN1
11bipolar disorder30.9PSEN2, GSK3B
12cerebrovascular disease30.9APOE, APP, ACE
13prion disease30.7APP, PSEN2, PSEN1
14down syndrome30.7APP, PSEN2, PSEN1, APOE
15tauopathy30.6PSEN1, APP
16parkinson's disease30.6GSK3B, PSEN1, APP, APOE
17cerebral amyloid angiopathy30.6APP
18amyotrophic lateral sclerosis type 1430.6APP, PSEN1
19age related macular degeneration30.6APOE, CTSD
20inclusion body myositis30.6APP
21diabetic nephropathy30.5APOE, HFE, ACE
22lewy body dementia30.5APOE, APP
23vascular disease30.4APOE, PSEN1, ACE
24creutzfeldt-jakob disease30.4APOE, APP
25hyperlipidemia type 310.8
26hemorrhage, intracerebral10.7PSEN1, PSEN2, APP, APOE
27amyloid tumor10.7APOE, APP, PSEN2, PSEN1
28binswanger's disease10.6APP, APOE
29stroke, hemorrhagic10.6APOE, APP
30microvascular complications of diabetes 710.6HFE
31huntington's disease10.6APP, PSEN2, PSEN1
32nephrotic syndrome10.6APOE, ACE, A2M
33porphyria cutanea tarda10.5HFE
34coronary artery anomaly10.5HFE, ACE, APOE
35alzheimer disease type 310.5
36alzheimer disease type 410.5
37hypertension10.4
38diabetes mellitus10.3
39obesity10.3
40spastic paraparesis10.3
41blindness10.3
42dermatitis10.3
43hydrocephalus10.3
44normal pressure hydrocephalus10.3
45atopic dermatitis10.3
46leukemia10.2
47cerebritis10.2
48breast cancer10.2
49hypercholesterolemia10.2
50immunodeficiency 27b, mycobacteriosis, ad10.2

Graphical network of the top 20 diseases related to Alzheimer's Disease:



Diseases related to alzheimer's disease

Symptoms for Alzheimer's Disease

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Drugs & Therapeutics for Alzheimer's Disease

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Drug clinical trials:

Search ClinicalTrials for Alzheimer's Disease

Search NIH Clinical Center for Alzheimer's Disease

Inferred drug relations via UMLS61/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Alzheimer's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alzheimer's Disease:
NEUROSTEM
Embryonic/Adult Cultured Cells Related to Alzheimer's Disease:
Umbilical cord blood-derived mesenchymal stem/progenitor cells , PMIDs: 23293711, 22015609

Genetic Tests for Alzheimer's Disease

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Genetic tests related to Alzheimer's Disease:

id Genetic test Affiliating Genes
1 Alzheimer Disease21
2 Alzheimer's Disease23

Anatomical Context for Alzheimer's Disease

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MalaCards organs/tissues related to Alzheimer's Disease:

32
Brain, Cortex, Testes, Endothelial, Temporal lobe, Monocytes, Amygdala, Liver, Cerebellum, Heart, Skin, T cells, Prefrontal cortex, Hypothalamus, Neutrophil, Smooth muscle, Thyroid, Eye, Retina, Breast, Placenta, Myeloid, Occipital lobe, Olfactory bulb, Thalamus, Caudate nucleus, Spinal cord, Kidney, Adrenal gland, Prostate, B cells, Cingulate cortex, Subthalamic nucleus, Adrenal cortex, Pineal, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alzheimer's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
2 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
3 BrainHippocampus  Affected by disease

Animal Models for Alzheimer's Disease or affiliated genes

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MGI Mouse Phenotypes related to Alzheimer's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0CTSD, BLMH, APOE, APP, MPO, PSEN1
2MP:000537610.9BLMH, APOE, APP, MPO, PSEN1, PSEN2
3MP:000538610.9BLMH, APOE, APP, PSEN1, PSEN2, ACE
4MP:001076810.9MPO, APP, APOE, BLMH, PSEN1, PSEN2
5MP:000537810.8BLMH, APOE, APP, PSEN1, PSEN2, ACE
6MP:000538110.6APOE, PSEN1, PSEN2, HFE, GSK3B, CTSD
7MP:000537910.6CTSD, GSK3B, ACE, PSEN2, PSEN1, APOE
8MP:000537110.5BLMH, APOE, PSEN1, PSEN2, HFE
9MP:000538510.4BLMH, APOE, MPO, PSEN1, PSEN2, ACE

Publications for Alzheimer's Disease

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Articles related to Alzheimer's Disease:

(show top 50)    (show all 6838)
idTitleAuthorsYear
1
Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI), and Alzheimer's disease (AD). (24902808)
2014
2
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. (24252572)
2013
3
The APOE E94/E94 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. (23652625)
2013
4
Screening of microRNAs associated with Alzheimer's disease using oxidative stress cell model and different strains of senescence accelerated mice. (24423585)
2013
5
AI^38 in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models. (24305500)
2013
6
No diagnostic value of plasma clusterin in Alzheimer's disease. (23209684)
2012
7
Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. (22349685)
2012
8
Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes. (22580620)
2012
9
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
10
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. (22926141)
2012
11
Apolipoprotein E I/4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis. (21124030)
2011
12
Cerebrospinal fluid profile of amyloid I^42 (AI^42), hTau and ubiquitin in North Indian Alzheimer's disease patients. (20599474)
2011
13
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
14
Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment. (19836440)
2010
15
Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease. (19897004)
2010
16
Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex. (21034788)
2010
17
Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. (20025970)
2010
18
Efficient processing of Alzheimer's disease amyloid-Beta peptides by neuroectodermally converted mesenchymal stem cells. (19469700)
2010
19
Clinical features of rapidly progressive Alzheimer's disease. (20453509)
2010
20
Critical evaluation of self-rated quality of life in mild cognitive impairment and Alzheimer's disease--further evidence for the impact of anosognosia and global cognitive impairment. (19262958)
2009
21
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. (19374444)
2009
22
An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. (19016491)
2009
23
Impact of rivastigmine on caregiver burden associated with Alzheimer's disease in both informal care and nursing home settings. (18582146)
2008
24
Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. (18363936)
2008
25
Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet? (18327642)
2008
26
Reduced insulin-induced phosphatidylinositol-3-kinase activation in peripheral blood mononuclear leucocytes from patients with Alzheimer's disease. (17986027)
2007
27
Fas antigen and sporadic Alzheimer's disease in Southern Italy: evaluation of two polymorphisms in the TNFRSF6 gene. (17406980)
2007
28
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease. (17426120)
2007
29
Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. (18057561)
2007
30
Cognitive changes in the preclinical phase of familial Alzheimer's disease. (17852592)
2007
31
A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease. (17240059)
2007
32
Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of AD. (15895300)
2006
33
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
34
The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients. (16445950)
2006
35
Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease. (16990077)
2006
36
Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer's disease brain. (15721223)
2005
37
A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. (14746899)
2004
38
HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease. (12967056)
2003
39
Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study. (12946561)
2003
40
Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease. (12424753)
2003
41
Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. (12218659)
2002
42
Negative symptoms, depression and Alzheimer's disease. (11994894)
2002
43
Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain. (10672313)
2000
44
Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease. (9886083)
1999
45
Unraveling the molecular pathway of Alzheimer's disease: research about presenilins gathers momentum. (9154244)
1996
46
Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative. (7485228)
1995
47
Heterogeneity of tau proteins in Alzheimer's disease. Evidence for increased expression of an isoform and preferential distribution of a phosphorylated isoform in neurites. (7679548)
1993
48
Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. (8497185)
1993
49
Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease. (1915258)
1991
50
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. (1944558)
1991

Variations for Alzheimer's Disease

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UniProtKB/Swiss-Prot genetic disease variations for Alzheimer's Disease:

63 (show all 13)
id Symbol AA change Variation ID SNP ID
1APPp.Ala692GlyVAR_000016
2APPp.Ala713ThrVAR_000019
3APPp.Ile716ValVAR_000020
4APPp.Val717IleVAR_000021
5APPp.Val717GlyVAR_000022
6APPp.Val717PheVAR_000023
7APPp.Val715MetVAR_010108
8APPp.Leu723ProVAR_010109
9APPp.Glu693GlyVAR_014215
10APPp.Thr714IleVAR_014218
11APPp.Val717LeuVAR_014219
12APPp.Thr714AlaVAR_032277
13APPp.Asp678AsnVAR_044424

Clinvar genetic disease variations for Alzheimer's Disease:

7
id Gene Name Type Significance SNP ID Assembly Location
1APPNM_000484.3(APP): c.2149G> A (p.Val717Ile)single nucleotide variantPathogenicrs63750264GRCh37Chr 21, 27264096: 27264096
2APPNM_000484.3(APP): c.2075C> G (p.Ala692Gly)single nucleotide variantPathogenicrs63750671GRCh37Chr 21, 27264170: 27264170
3APPNM_000484.3(APP): c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu)indelPathogenicrs281865161GRCh37Chr 21, 27269938: 27269939
4APPNM_000484.3(APP): c.2078A> G (p.Glu693Gly)single nucleotide variantPathogenicrs63751039GRCh37Chr 21, 27264167: 27264167
5APPNM_000484.3(APP): c.2018C> T (p.Ala673Val)single nucleotide variantPathogenicrs193922916GRCh37Chr 21, 27269931: 27269931
6HFENM_000410.3(HFE): c.845G> A (p.Cys282Tyr)single nucleotide variantPathogenic, confers sensitivity, risk factorrs1800562GRCh37Chr 6, 26093141: 26093141
7MT-ND1m.3397A> Gsingle nucleotide variantPathogenicrs199476120GRCh37Chr MT, 3397: 3397

Expression for genes affiliated with Alzheimer's Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Alzheimer's Disease patients vs. healthy controls: 31 (show all 376)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1MICAL2microtubule associated monooxygenase, calponin and LIM domain containing 2Brain-7.640.000
2DYNC1I1dynein, cytoplasmic 1, intermediate chain 1Brain-7.380.000
3RPH3Arabphilin 3A homolog (mouse)Brain-7.380.000
4ATP2B1ATPase, Ca++ transporting, plasma membrane 1Brain-7.160.000
5ELMOD1ELMO/CED-12 domain containing 1Brain-7.160.000
6NELL2NEL-like 2 (chicken)Brain-7.160.000
7RASGRF1Ras protein-specific guanine nucleotide-releasing factor 1Brain-7.160.000
8CAMKK2calcium/calmodulin-dependent protein kinase kinase 2, betaBrain-6.970.000
9ICAM5intercellular adhesion molecule 5, telencephalinBrain-6.970.000
10PAK1p21 protein (Cdc42/Rac)-activated kinase 1Brain-6.970.000
11PDE2Aphosphodiesterase 2A, cGMP-stimulatedBrain-6.970.000
12PI4KAphosphatidylinositol 4-kinase, catalytic, alphaBrain-6.800.000
13PREPLprolyl endopeptidase-likeBrain-6.800.000
14SLIT1slit homolog 1 (Drosophila)Brain-6.800.000
15WBSCR17Williams-Beuren syndrome chromosome region 17Brain-6.800.000
16CLSTN3calsyntenin 3Brain-6.640.000
17GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2ABrain-6.510.000
18GUCY1B3guanylate cyclase 1, soluble, beta 3Brain-6.510.000
19CAMK1Gcalcium/calmodulin-dependent protein kinase IGBrain-6.380.000
20KCNIP4Kv channel interacting protein 4Brain-6.380.000
21SLC23A2solute carrier family 23 (ascorbic acid transporter), member 2Brain-6.380.000
22ANKS1Bankyrin repeat and sterile alpha motif domain containing 1BBrain-6.160.000
23FARSBphenylalanyl-tRNA synthetase, beta subunitBrain-6.160.000
24PTPLAD1protein tyrosine phosphatase-like A domain containing 1Brain-6.160.000
25ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptideBrain-6.060.000
26FAM120Bfamily with sequence similarity 120BBrain-6.060.000
27ITFG1integrin alpha FG-GAP repeat containing 1Brain-6.060.000
28PRDM8PR domain containing 8Brain-6.060.000
29EGFEM1PEGF-like and EMI domain containing 1, pseudogeneBlood-4.440.000
30ZMYND11zinc finger, MYND-type containing 11Blood-4.320.000
31FFAR4free fatty acid receptor 4Blood-4.180.000
32PAQR9progestin and adipoQ receptor family member IXBlood-3.920.000
33EDNRBendothelin receptor type BBlood-3.920.002
34LOC100133131uncharacterized LOC100133131Blood+3.830.000
35KIAA1462KIAA1462Blood-3.760.000
36AC074289.1uncharacterized LOC100507006Brain+3.730.000
37SLC17A8solute carrier family 17 (vesicular glutamate transporter), member 8Blood+3.710.001
38AZU1azurocidin 1Blood+3.700.024
39TATtyrosine aminotransferaseBlood-3.700.004
40LOC100130642uncharacterized LOC100130642Blood-3.620.001
41GPRC5BG protein-coupled receptor, class C, group 5, member BBlood-3.590.005
42CXCL3chemokine (C-X-C motif) ligand 3Blood+3.590.004
43ARPP21cAMP-regulated phosphoprotein, 21kDaBlood+3.550.004
44KCNK1potassium channel, subfamily K, member 1Blood-3.550.003
45KITLGKIT ligandBlood+3.530.001
46DNMBPdynamin binding proteinBlood-3.490.002
47TAAR1trace amine associated receptor 1Blood-3.490.021
48ARL10ADP-ribosylation factor-like 10Blood-3.470.000
49LMBRD2LMBR1 domain containing 2Blood-3.430.002
50LAMB4laminin, beta 4Blood-3.430.001
51RHOJras homolog family member JBlood-3.410.007
52AKR1D1aldo-keto reductase family 1, member D1Blood-3.370.019
53FBXO4F-box protein 4Blood-3.370.002
54PDE1Cphosphodiesterase 1C, calmodulin-dependent 70kDaBlood+3.370.016
55AGAP1ArfGAP with GTPase domain, ankyrin repeat and PH domain 1Blood-3.360.039
56CES1P1carboxylesterase 1 pseudogene 1Blood-3.340.003
57EMP1epithelial membrane protein 1Blood-3.310.031
58PCDH7protocadherin 7Blood-3.300.001
59MT1Gmetallothionein 1GBrain+3.290.000
60ALAS2aminolevulinate, delta-, synthase 2Blood+3.280.010
61SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6DBlood+3.250.020
62ZAR1zygote arrest 1Blood-3.240.023
63TMEM259transmembrane protein 259Blood-3.230.047
64PARM1prostate androgen-regulated mucin-like protein 1Blood-3.220.042
65EMP2epithelial membrane protein 2Blood-3.220.001
66PREX2phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2Blood-3.210.032
67DNHD1dynein heavy chain domain 1Blood-3.210.026
68ST7-AS2ST7 antisense RNA 2Blood-3.200.033
69SLC4A1solute carrier family 4 (anion exchanger), member 1 (Diego blood group)Blood+3.200.001
70B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Blood-3.200.037
71TNS1tensin 1Blood+3.180.002
72ZNF425zinc finger protein 425Blood+3.170.006
73HLA-DOAmajor histocompatibility complex, class II, DO alphaBlood-3.160.001
74RBPMS2RNA binding protein with multiple splicing 2Blood+3.160.012
75DNAH6dynein, axonemal, heavy chain 6Blood-3.150.011
76FAM170Bfamily with sequence similarity 170, member BBlood+3.150.000
77RGL3ral guanine nucleotide dissociation stimulator-like 3Blood-3.120.025
78PLCE1phospholipase C, epsilon 1Blood-3.120.001
79FAM83Cfamily with sequence similarity 83, member CBlood-3.100.048
80MICALL2MICAL-like 2Blood-3.100.023
81CAPRIN2caprin family member 2Blood-3.100.000
82GNG13guanine nucleotide binding protein (G protein), gamma 13Blood+3.090.004
83COX11cytochrome c oxidase assembly homolog 11 (yeast)Blood-3.080.009
84ADAM22ADAM metallopeptidase domain 22Blood-3.080.019
85UNC80unc-80 homolog (C. elegans)Blood-3.070.007
86INTS1integrator complex subunit 1Blood-3.070.009
87AGAP11ankyrin repeat and GTPase domain Arf GTPase activating protein 11Blood+3.060.009
88NT5E5'-nucleotidase, ecto (CD73)Blood-3.050.048
89FREM1FRAS1 related extracellular matrix 1Blood+3.040.001
90IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)Blood-3.040.019
91SLC35D3solute carrier family 35, member D3Blood+3.040.048
92LOC100506082uncharacterized LOC100506082Blood-3.030.006
93TNXBtenascin XBBlood-3.020.012
94IL17Ainterleukin 17ABlood-3.010.005
95CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 5Blood-3.010.040
96IQUBIQ motif and ubiquitin domain containingBlood-3.010.026
97COL4A5collagen, type IV, alpha 5Blood-3.010.002
98CSPG4chondroitin sulfate proteoglycan 4Blood-3.000.024
99ALDOBaldolase B, fructose-bisphosphateBlood-2.970.047
100ASCL1achaete-scute family bHLH transcription factor 1Blood+2.970.008
101S100A4S100 calcium binding protein A4Brain+2.960.000
102MEP1Ameprin A, alpha (PABA peptide hydrolase)Blood+2.960.005
103MTMR1myotubularin related protein 1Blood-2.960.001
104EFCAB13EF-hand calcium binding domain 13Blood-2.960.034
105CASD1CAS1 domain containing 1Blood-2.950.019
106TMCO5Btransmembrane and coiled-coil domains 5B, pseudogeneBlood+2.950.022
107RTP3receptor (chemosensory) transporter protein 3Blood+2.950.001
108DIRC1disrupted in renal carcinoma 1Blood+2.950.021
109IQCA1IQ motif containing with AAA domain 1Blood-2.940.045
110SMAD5-AS1SMAD5 antisense RNA 1Blood+2.940.003
111SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Blood-2.930.002
112LOC339240keratin 17 pseudogeneBlood+2.920.001
113VPS33Avacuolar protein sorting 33 homolog A (S. cerevisiae)Blood+2.910.001
114PDE4Aphosphodiesterase 4A, cAMP-specificBlood-2.900.003
115FLJ90680FLJ90680 proteinBlood-2.900.001
116SORBS2sorbin and SH3 domain containing 2Blood+2.890.009
117DESdesminBrain+2.890.000
118ZNF135zinc finger protein 135Blood+2.890.008
119SULT1E1sulfotransferase family 1E, estrogen-preferring, member 1Blood-2.890.012
120SPANXA2-OT1SPANXA2 overlapping transcript 1 (non-protein coding)Blood-2.880.011
121PPP1R14Bprotein phosphatase 1, regulatory (inhibitor) subunit 14BBlood-2.880.004
122GSTA3glutathione S-transferase alpha 3Blood-2.880.013
123CYMPchymosin pseudogeneBlood-2.870.001
124LOC100287808uncharacterized LOC100287808Blood-2.870.008
125ADAMTSL1ADAMTS-like 1Blood+2.870.042
126FZD10frizzled class receptor 10Blood+2.850.011
127SLC30A7solute carrier family 30 (zinc transporter), member 7Blood-2.850.008
128DLEU7deleted in lymphocytic leukemia, 7Blood-2.850.004
129LAYNlayilinBlood-2.830.007
130FAM64Afamily with sequence similarity 64, member ABlood-2.830.026
131AHNAKAHNAK nucleoproteinBlood+2.830.001
132TPD52L1tumor protein D52-like 1Blood-2.810.003
133GAREMLGRB2 associated, regulator of MAPK1-likeBlood+2.810.042
134LOC283788FSHD region gene 1 pseudogeneBlood-2.800.021
135CDH8cadherin 8, type 2Blood+2.800.023
136CXADRcoxsackie virus and adenovirus receptorBlood-2.790.035
137CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1Blood-2.790.001
138MYO7Bmyosin VIIBBlood-2.780.022
139C1orf220chromosome 1 open reading frame 220Blood-2.780.038
140KCNE4potassium voltage-gated channel, Isk-related family, member 4Blood+2.770.017
141ZNF233zinc finger protein 233Blood-2.770.005
142SPON1spondin 1, extracellular matrix proteinBlood-2.770.011
143KRT19P2keratin 19 pseudogene 2Blood-2.760.038
144PMEPA1prostate transmembrane protein, androgen induced 1Blood-2.760.047
145GJA10gap junction protein, alpha 10, 62kDaBlood+2.760.003
146MCAMmelanoma cell adhesion moleculeBlood+2.760.000
147SOX9SRY (sex determining region Y)-box 9Blood+2.750.034
148TCF20transcription factor 20 (AR1)Blood+2.750.016
149SMIM7small integral membrane protein 7Brain+2.730.000
150ZNF81zinc finger protein 81Blood-2.730.009
151APOA2apolipoprotein A-IIBlood-2.730.042
152CHRM3cholinergic receptor, muscarinic 3Blood+2.720.044
153TMEM217transmembrane protein 217Blood-2.720.005
154ZNF519zinc finger protein 519Blood-2.720.014
155MAN1A2mannosidase, alpha, class 1A, member 2Blood-2.710.032
156PCSK2proprotein convertase subtilisin/kexin type 2Blood-2.710.028
157NELL1NEL-like 1 (chicken)Blood-2.710.037
158ABCC11ATP-binding cassette, sub-family C (CFTR/MRP), member 11Blood+2.700.002
159TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)Blood-2.700.009
160TONSLtonsoku-like, DNA repair proteinBlood-2.700.012
161DSELdermatan sulfate epimerase-likeBlood+2.700.006
162SRRM5serine/arginine repetitive matrix 5Blood-2.690.009
163ITIH3inter-alpha-trypsin inhibitor heavy chain 3Blood+2.690.011
164PWRN1Prader-Willi region non-protein coding RNA 1Blood-2.690.014
165FAM201Afamily with sequence similarity 201, member ABlood+2.680.037
166MTPAPmitochondrial poly(A) polymeraseBrain+2.680.000
167BTG4B-cell translocation gene 4Blood+2.670.017
168ZNF44zinc finger protein 44Blood+2.670.000
169INADLInaD-like (Drosophila)Blood-2.640.038
170SLC6A8solute carrier family 6 (neurotransmitter transporter), member 8Blood+2.640.007
171SPRR2Bsmall proline-rich protein 2BBlood+2.630.038
172TRIOtrio Rho guanine nucleotide exchange factorBlood+2.600.013
173SPINK13serine peptidase inhibitor, Kazal type 13 (putative)Blood+2.600.013
174ALDH4A1aldehyde dehydrogenase 4 family, member A1Blood+2.600.006
175IL22RA2interleukin 22 receptor, alpha 2Blood+2.590.012
176ROPN1Brhophilin associated tail protein 1BBlood+2.590.039
177LOC283485uncharacterized LOC283485Blood+2.590.008
178LRRTM1leucine rich repeat transmembrane neuronal 1Blood-2.590.030
179ZIC5Zic family member 5Blood-2.590.012
180MYH3myosin, heavy chain 3, skeletal muscle, embryonicBlood+2.580.002
181FAM161Afamily with sequence similarity 161, member ABlood-2.570.041
182CRNNcornulinBlood-2.570.012
183WNT5Awingless-type MMTV integration site family, member 5ABlood-2.570.022
184PGM5phosphoglucomutase 5Blood-2.550.001
185TNP2transition protein 2 (during histone to protamine replacement)Blood-2.550.046
186TMPRSS5transmembrane protease, serine 5Blood-2.540.001
187CCKARcholecystokinin A receptorBlood-2.530.022
188DAZAP2DAZ associated protein 2Blood+2.530.008
189CRISP1cysteine-rich secretory protein 1Blood-2.530.012
190LRP12low density lipoprotein receptor-related protein 12Blood+2.530.020
191VWA3Avon Willebrand factor A domain containing 3ABlood-2.530.039
192GUSBP4glucuronidase, beta pseudogene 4Blood-2.520.040
193ACVR1Bactivin A receptor, type IBBlood-2.520.022
194LINC00521long intergenic non-protein coding RNA 521Blood-2.510.039
195AMFRautocrine motility factor receptor, E3 ubiquitin protein ligaseBlood-2.510.025
196VWDEvon Willebrand factor D and EGF domainsBlood+2.500.008
197MAP2K7mitogen-activated protein kinase kinase 7Blood+2.500.002
198CETN1centrin, EF-hand protein, 1Blood-2.500.018
199CCNYcyclin YBlood-2.500.025
200NDST4N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4Blood-2.490.030
201EFCAB6EF-hand calcium binding domain 6Blood-2.480.034
202CDKN2Dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)Blood-2.470.018
203COL10A1collagen, type X, alpha 1Blood-2.470.018
204NKAPP1NFKB activating protein pseudogene 1Blood-2.470.012
205SLC44A1solute carrier family 44 (choline transporter), member 1Blood-2.470.038
206MAGEA4melanoma antigen family A, 4Blood-2.470.003
207MAP1Bmicrotubule-associated protein 1BBlood-2.470.005
208TBX5T-box 5Blood+2.470.010
209CNTN4contactin 4Blood-2.460.047
210CRHR1corticotropin releasing hormone receptor 1Blood+2.460.023
211LACE1lactation elevated 1Blood-2.460.027
212TTC28-AS1TTC28 antisense RNA 1Blood+2.460.001
213SLC2A12solute carrier family 2 (facilitated glucose transporter), member 12Blood-2.450.048
214M1APmeiosis 1 associated proteinBlood-2.440.012
215ARR3arrestin 3, retinal (X-arrestin)Blood-2.440.013
216TMC6transmembrane channel-like 6Blood-2.440.007
217GPR161G protein-coupled receptor 161Blood+2.430.005
218MUC3Bmucin 3B, cell surface associatedBlood-2.430.019
219CSRP2cysteine and glycine-rich protein 2Blood-2.430.006
220CDC42BPACDC42 binding protein kinase alpha (DMPK-like)Blood+2.430.035
221RASEFRAS and EF-hand domain containingBlood-2.420.018
222ZNF264zinc finger protein 264Blood-2.410.030
223GRIP2glutamate receptor interacting protein 2Blood+2.410.019
224TM4SF20transmembrane 4 L six family member 20Blood-2.410.002
225CALCRLcalcitonin receptor-likeBlood+2.410.027
226CACNA1Bcalcium channel, voltage-dependent, N type, alpha 1B subunitBlood-2.400.008
227LOC152225uncharacterized LOC152225Blood+2.400.040
228TTC18tetratricopeptide repeat domain 18Blood+2.400.036
229RIPPLY1ripply transcriptional repressor 1Blood-2.400.042
230LOC730101uncharacterized LOC730101Blood-2.390.016
231VSTM4V-set and transmembrane domain containing 4Blood-2.390.043
232SPATA9spermatogenesis associated 9Blood-2.380.038
233PER2period circadian clock 2Blood-2.370.035
234CYP2A13cytochrome P450, family 2, subfamily A, polypeptide 13Blood+2.370.027
235CEP70centrosomal protein 70kDaBlood-2.360.026
236RBM43RNA binding motif protein 43Blood+2.360.001
237ZNF595zinc finger protein 595Blood-2.360.036
238DENND5BDENN/MADD domain containing 5BBlood-2.350.031
239TPM1tropomyosin 1 (alpha)Blood+2.350.004
240NTNG1netrin G1Blood+2.330.011
241GIPC3GIPC PDZ domain containing family, member 3Blood-2.320.005
242FOXP3forkhead box P3Blood-2.320.026
243HIF3Ahypoxia inducible factor 3, alpha subunitBlood+2.320.001
244HGDhomogentisate 1,2-dioxygenaseBlood+2.320.036
245SLNsarcolipinBlood-2.320.042
246C21orf58chromosome 21 open reading frame 58Blood+2.320.014
247CXCL11chemokine (C-X-C motif) ligand 11Blood+2.320.033
248KIAA1549KIAA1549Blood-2.320.029
249PANX2pannexin 2Blood+2.320.042
250VEPH1ventricular zone expressed PH domain-containing 1Blood+2.310.046
251GPR144G protein-coupled receptor 144Blood+2.310.007
252JUNjun proto-oncogeneBlood-2.310.021
253TBC1D16TBC1 domain family, member 16Blood-2.310.015
254C2CD2LC2CD2-likeBlood-2.310.006
255RGSL1regulator of G-protein signaling like 1Blood-2.310.042
256VWA1von Willebrand factor A domain containing 1Blood-2.300.041
257PDE6Bphosphodiesterase 6B, cGMP-specific, rod, betaBlood-2.290.044
258DOCK6dedicator of cytokinesis 6Blood+2.290.017
259IGHimmunoglobulin heavy locusBlood+2.290.002
260NME3NME/NM23 nucleoside diphosphate kinase 3Brain+2.280.000
261MAATS1MYCBP-associated, testis expressed 1Blood+2.280.005
262CROCCP2ciliary rootlet coiled-coil, rootletin pseudogene 2Blood-2.280.043
263COL5A1collagen, type V, alpha 1Blood+2.280.029
264NOX1NADPH oxidase 1Blood-2.280.024
265ATAT1alpha tubulin acetyltransferase 1Blood+2.270.048
266POU3F2POU class 3 homeobox 2Blood-2.270.014
267RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic)Blood+2.260.050
268OPALINoligodendrocytic myelin paranodal and inner loop proteinBlood-2.250.049
269EPS8L2EPS8-like 2Blood-2.250.021
270PDE9Aphosphodiesterase 9ABlood+2.250.044
271SOBPsine oculis binding protein homolog (Drosophila)Blood+2.250.036
272LIMK1LIM domain kinase 1Blood-2.240.031
273ADCY10adenylate cyclase 10 (soluble)Blood-2.240.007
274IFNW1interferon, omega 1Blood+2.240.007
275GPR137G protein-coupled receptor 137Blood+2.230.049
276TXNRD3thioredoxin reductase 3Blood-2.230.044
277LOC100128198uncharacterized LOC100128198Blood+2.220.043
278POLNpolymerase (DNA directed) nuBlood+2.220.017
279PDE4Dphosphodiesterase 4D, cAMP-specificBlood-2.220.047
280C16orf71chromosome 16 open reading frame 71Blood+2.220.047
281KIF1Ckinesin family member 1CBrain+2.210.000
282PER4period circadian clock 3 pseudogeneBlood-2.200.018
283ATXN7L1ataxin 7-like 1Blood-2.200.013
284PLEKHB1pleckstrin homology domain containing, family B (evectins) member 1Blood-2.200.010
285FOXI1forkhead box I1Blood-2.190.028
286CRMP1collapsin response mediator protein 1Blood+2.190.027
287REG3Gregenerating islet-derived 3 gammaBlood-2.190.047
288LINC00612long intergenic non-protein coding RNA 612Blood-2.190.040
289PDIA2protein disulfide isomerase family A, member 2Blood+2.180.032
290CABP2calcium binding protein 2Blood-2.180.030
291ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)Blood-2.180.005
292ZNF462zinc finger protein 462Blood+2.170.037
293SERTAD4SERTA domain containing 4Blood-2.170.004
294PPEF1protein phosphatase, EF-hand calcium binding domain 1Blood+2.170.033
295PPARGC1Bperoxisome proliferator-activated receptor gamma, coactivator 1 betaBlood-2.160.033
296LOC154872putative uncharacterized protein LOC154872Blood-2.160.027
297PHKG1phosphorylase kinase, gamma 1 (muscle)Blood-2.160.043
298AKT2v-akt murine thymoma viral oncogene homolog 2Blood+2.150.046
299SYN2synapsin IIBlood+2.150.024
300ZNF709zinc finger protein 709Blood-2.140.037
301RCBTB2regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2Blood-2.140.008
302CLCN7chloride channel, voltage-sensitive 7Blood+2.130.036
303MAGOHBmago-nashi homolog B (Drosophila)Blood-2.120.049
304RPL35Aribosomal protein L35aBlood+2.120.032
305PDLIM3PDZ and LIM domain 3Blood+2.100.046
306C9orf116chromosome 9 open reading frame 116Blood-2.100.036
307MAP4K4mitogen-activated protein kinase kinase kinase kinase 4Brain+2.090.000
308ANKUB1ankyrin repeat and ubiquitin domain containing 1Blood+2.080.013
309SPATA45spermatogenesis associated 45Blood-2.070.017
310FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)Blood-2.070.041
311FOXO3forkhead box O3Blood+2.070.007
312IGFBP2insulin-like growth factor binding protein 2, 36kDaBlood-2.070.008
313ITGA11integrin, alpha 11Blood-2.070.015
314MAGI1membrane associated guanylate kinase, WW and PDZ domain containing 1Blood-2.050.031
315KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1Blood+2.050.017
316CEP152centrosomal protein 152kDaBlood-2.050.005
317C1orf101chromosome 1 open reading frame 101Blood+2.050.036
318LAMA4laminin, alpha 4Blood-2.050.036
319GPR158G protein-coupled receptor 158Blood+2.040.043
320FGF14fibroblast growth factor 14Blood+2.040.032
321FITM2fat storage-inducing transmembrane protein 2Blood+2.040.035
322CENPAcentromere protein ABlood-2.040.038
323NRP2neuropilin 2Blood+2.030.020
324BTN1A1butyrophilin, subfamily 1, member A1Blood-2.030.008
325P2RX6purinergic receptor P2X, ligand-gated ion channel, 6Blood-2.030.021
326TEAD4TEA domain family member 4Blood+2.020.046
327FLRT3fibronectin leucine rich transmembrane protein 3Blood-2.020.029
328ZNF214zinc finger protein 214Blood-2.010.042
329DYNC1H1dynein, cytoplasmic 1, heavy chain 1Blood-1.990.033
330NUB1negative regulator of ubiquitin-like proteins 1Blood-1.980.028
331PIEZO2piezo-type mechanosensitive ion channel component 2Blood-1.980.037
332SH3TC2SH3 domain and tetratricopeptide repeats 2Blood+1.980.019
333BDH23-hydroxybutyrate dehydrogenase, type 2Blood-1.970.017
334DGCR8DGCR8 microprocessor complex subunitBlood+1.960.034
335TGFB3transforming growth factor, beta 3Brain+1.960.000
336LZTS3leucine zipper, putative tumor suppressor family member 3Blood-1.950.034
337MARVELD3MARVEL domain containing 3Blood+1.950.034
338OPRD1opioid receptor, delta 1Blood+1.950.016
339CYP11B1cytochrome P450, family 11, subfamily B, polypeptide 1Blood+1.940.048
340CSMD2CUB and Sushi multiple domains 2Blood-1.920.044
341PAGE5P antigen family, member 5 (prostate associated)Blood+1.890.035
342FXYD1FXYD domain containing ion transport regulator 1Blood-1.890.016
343RNASE7ribonuclease, RNase A family, 7Blood+1.890.018
344BIRC5baculoviral IAP repeat containing 5Blood+1.880.035
345CADM3cell adhesion molecule 3Blood+1.870.032
346CARScysteinyl-tRNA synthetaseBlood+1.870.034
347MYL4myosin, light chain 4, alkali; atrial, embryonicBlood+1.860.026
348FOXO4forkhead box O4Brain+1.850.000
349HIC1hypermethylated in cancer 1Blood+1.840.025
350BTNL9butyrophilin-like 9Blood+1.800.030
351TNFRSF25tumor necrosis factor receptor superfamily, member 25Brain+1.800.000
352CDRT1CMT1A duplicated region transcript 1Blood-1.800.021
353EXOSC2exosome component 2Blood-1.770.034
354MTURNmaturin, neural progenitor differentiation regulator homolog (Xenopus)Brain+1.760.000
355GMPRguanosine monophosphate reductaseBrain+1.750.000
356SLC2A1solute carrier family 2 (facilitated glucose transporter), member 1Blood+1.750.023
357CDH23cadherin-related 23Brain+1.730.000
358RFC4replication factor C (activator 1) 4, 37kDaBrain+1.730.000
359RCVRNrecoverinBlood+1.730.018
360HNRNPMheterogeneous nuclear ribonucleoprotein MBlood-1.720.046
361GSX2GS homeobox 2Blood+1.710.047
362TRMT1tRNA methyltransferase 1 homolog (S. cerevisiae)Brain+1.690.000
363RAB13RAB13, member RAS oncogene familyBrain+1.680.000
364RPL10ribosomal protein L10Blood-1.660.019
365ZNF460zinc finger protein 460Blood-1.650.037
366CATSPER2cation channel, sperm associated 2Brain+1.630.000
367MACROD1MACRO domain containing 1Brain+1.630.000
368SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Brain+1.630.000
369ZNF692zinc finger protein 692Brain+1.620.000
370SNRNP70small nuclear ribonucleoprotein 70kDa (U1)Brain+1.560.000
371S100A6S100 calcium binding protein A6Brain+1.530.000
372SNORD60small nucleolar RNA, C/D box 60Brain+1.520.000
373MYL9myosin, light chain 9, regulatoryBrain+1.480.000
374DDX46DEAD (Asp-Glu-Ala-Asp) box polypeptide 46Brain+1.450.000
375SHKBP1SH3KBP1 binding protein 1Brain+1.440.000
376NOVA1neuro-oncological ventral antigen 1Brain+1.430.000

Expression patterns in normal tissues for genes affiliated with Alzheimer's Disease

Search GEO for disease gene expression data for Alzheimer's Disease.

Pathways for genes affiliated with Alzheimer's Disease

About this section

Pathways related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6GSK3B, A2M, PSEN2, PSEN1, APP, APOE
210.6APP, PSEN1, PSEN2, ACE, CTSD
310.6APOE, APP, PSEN1, PSEN2, GSK3B
4
Show member pathways
Alzheimers Disease37
10.6GSK3B, PSEN2, PSEN1, APP, APOE
510.6APOE, APP, ACE, A2M
6
Show member pathways
10.6PSEN1, COL25A1, A2M, CTSD
7
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
10.6APP, PSEN1, PSEN2, GSK3B
810.6GSK3B, PSEN2, PSEN1, APP
9
Show member pathways
10.6PSEN1, PSEN2, PLD3, GSK3B
1010.6GSK3B, APP, APOE
1110.6GSK3B, PSEN2, PSEN1
1210.6PSEN2, GSK3B, CTSD
13
Show member pathways
Vitamin B12 Metabolism37
10.5MPO, APOE
1410.5PSEN2, PSEN1

Compounds for genes affiliated with Alzheimer's Disease

About this section

Compounds related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1cholesterol44 29 25 1214.2A2M, APP, APOE, PSEN2, ACE, HFE
2serine4411.1APOE, APP, MPO, CTSD, PSEN2, A2M
3valine4411.1PSEN2, PSEN1, MPO, APOE, APP, CTSD
4aspartate4411.1APOE, APP, PSEN1, PSEN2, HFE, CTSD
5h2o24411.1APOE, APP, MPO, PSEN1, PSEN2, CTSD
6alanine4411.0APOE, APP, HFE, PSEN1, CTSD, GSK3B
7bleomycin44 1212.0PSEN1, APOE, BLMH, CTSD
84-hydroxynonenal44 2512.0APOE, APP, MPO, PSEN1
9lactacystin4411.0PSEN2, PSEN1, APP, APOE
10cysteine4411.0APP, BLMH, APOE, PSEN1, HFE, CTSD
11creatinine4411.0APOE, APP, MPO, ACE, CTSD
12heparin44 29 25 1214.0CTSD, A2M, MPO, APP, APOE
13choline44 25 1213.0PSEN2, APP, PSEN1, PLD3
14cysteamine44 25 1213.0MPO, APOE, CTSD
15testosterone44 60 25 1214.0HFE, APOE, CTSD, APP, GSK3B
16s-1824411.0PSEN1, PSEN2
17ab-424411.0PSEN2, APP
18lipid4411.0HFE, GSK3B, APOE, APP, PSEN1, ACE
19l-685,4586011.0PSEN1, PSEN2
20dapt6010.9PSEN1, PSEN2
21ascorbic acid44 2511.9MPO, HFE, CTSD, APOE
22begacestat6010.9PSEN2, PSEN1
23kininogen4410.9MPO, ACE, APP
24jlk 66010.9PSEN2, PSEN1
25mrk 5606010.9PSEN1, PSEN2
26acetylcholine44 50 29 25 1214.9ACE, APOE, APP, MPO
27vitamin b124410.9PSEN1, MPO, APOE
28thioflavine s4410.9APP, APOE
29dihydralazine4410.9MPO, ACE
30metrifonate4410.9APP, APOE
31vegf4410.9CTSD, APOE, APP, MPO, PSEN2
32chloroquine44 3 50 29 1214.9APP, CTSD, APOE
3324s-hydroxy-cholesterol4410.9APP, APOE
34thioflavin t4410.9APP, APOE
35biotin44 25 1212.9PSEN1, APOE, PSEN2
36tacrine44 1211.9APOE, APP
37potassium44 25 1212.8PSEN1, PSEN2, GSK3B, ACE
38nitric oxide44 25 1212.8PSEN1, CTSD, PSEN2, MPO, ACE
39methionine sulfoxide44 25 1212.8MPO, APP
40paraffin4410.8APOE, CTSD, PSEN2, MPO
41donepezil44 50 25 1213.8APOE, APP
42sele4410.8APOE, ACE
43glutamate4410.8APOE, PSEN1, PSEN2, CTSD, APP
44sodium azide4410.7MPO, APP
45glutamine4410.7CTSD, PSEN1, APP, APOE
46thermolysin4410.6CTSD, A2M
47lysine4410.6PSEN1, PSEN2, A2M, CTSD
48hydralazine44 50 1212.5MPO, ACE
49thiorphan44 29 1212.4ACE, APP
50lactate4410.3PSEN2, BLMH, CTSD, MPO

GO Terms for genes affiliated with Alzheimer's Disease

About this section

Cellular components related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:07006210.9BLMH, APOE, APP, MPO, ACE, PLD3
2dendritic shaftGO:04319810.8GSK3B, PSEN2, PSEN1, APP
3ciliary rootletGO:03525310.8APP, PSEN1, PSEN2
4perinuclear region of cytoplasmGO:04847110.8APP, PSEN1, PSEN2, HFE, GSK3B
5neuromuscular junctionGO:03159410.8PSEN2, PSEN1, APP
6integral component of plasma membraneGO:00588710.8HLA-H, APP, PSEN1, PSEN2, COL25A1, HFE
7neuronal cell bodyGO:04302510.7APOE, PSEN1, PSEN2, GSK3B
8growth coneGO:03042610.6GSK3B, PSEN2, PSEN1
9axonGO:03042410.6PSEN2, PSEN1, APP
10extracellular regionGO:00557610.5APOE, APP, ACE, COL25A1, A2M, CTSD
11MHC class I protein complexGO:04261210.5HLA-H, HFE
12membrane raftGO:04512110.3GSK3B, PSEN2, PSEN1

Biological processes related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.0APP, PSEN1, COL25A1, A2M, CTSD
2extracellular matrix disassemblyGO:02261711.0CTSD, A2M, COL25A1, PSEN1
3positive regulation of coagulationGO:05082010.9PSEN2, PSEN1
4smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.9PSEN1, APP
5myeloid leukocyte differentiationGO:00257310.9PSEN2, PSEN1
6response to oxidative stressGO:00697910.9APP, MPO, PSEN1
7regulation of epidermal growth factor-activated receptor activityGO:00717610.9APP, PSEN2
8endoplasmic reticulum calcium ion homeostasisGO:03246910.9PSEN2, PSEN1
9amyloid precursor protein catabolic processGO:04298710.9PSEN2, PSEN1
10antigen processing and presentation of peptide antigen via MHC class IGO:00247410.9HLA-H, BLMH, HFE
11beta-amyloid metabolic processGO:05043510.9PSEN2, PSEN1
12low-density lipoprotein particle remodelingGO:03437410.8MPO, APOE
13anagenGO:04264010.8PSEN2, PSEN1
14negative regulation of protein complex assemblyGO:03133310.8GSK3B, PSEN2
15regulation of neuronal synaptic plasticityGO:04816810.8GSK3B, APOE
16dorsal/ventral neural tube patterningGO:02190410.8PSEN1, PSEN2
17brain morphogenesisGO:04885410.8PSEN1, PSEN2
18hematopoietic progenitor cell differentiationGO:00224410.8PSEN1, PSEN2
19Notch signaling pathwayGO:00721910.7APP, PSEN1, PSEN2
20cell fate specificationGO:00170810.7PSEN1, PSEN2
21regulation of protein bindingGO:04339310.7PSEN1, APP
22T cell activation involved in immune responseGO:00228610.6PSEN2, PSEN1
23membrane protein ectodomain proteolysisGO:00650910.6PSEN1, PSEN2
24positive regulation of T cell mediated cytotoxicityGO:00191610.5HLA-H, HFE
25protein processingGO:01648510.5PSEN2, PSEN1
26Notch receptor processingGO:00722010.4PSEN2, PSEN1
27autophagic vacuole assemblyGO:00004510.2CTSD, PSEN1

Molecular functions related to Alzheimer's Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8BLMH, APOE, APP, PSEN1, PSEN2, ACE
2aspartic-type endopeptidase activityGO:00419010.7CTSD, PSEN2, PSEN1
3endopeptidase activityGO:00417510.7ACE, PSEN2, PSEN1
4heparin bindingGO:00820110.7APOE, APP, MPO, COL25A1
5tau protein bindingGO:04815610.6GSK3B, APOE
6peptide antigen bindingGO:04260510.5HFE, HLA-H
7carboxypeptidase activityGO:00418010.4BLMH, ACE
8beta-amyloid bindingGO:00154010.2COL25A1, APOE

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