MCID: AMR003
MIFTS: 38

Amaurosis Fugax malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Amaurosis Fugax

Aliases & Descriptions for Amaurosis Fugax:

Name: Amaurosis Fugax 50 29
Transient Monocular Blindness 50

Classifications:



External Ids:

ICD10 33 G45.3

Summaries for Amaurosis Fugax

MalaCards based summary : Amaurosis Fugax, also known as transient monocular blindness, is related to transient cerebral ischemia and mini stroke. An important gene associated with Amaurosis Fugax is F5 (Coagulation Factor V), and among its related pathways/superpathways are Degradation of the extracellular matrix and Adhesion. The drugs Mannitol and diuretics have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and prostate, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 71 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

Related Diseases for Amaurosis Fugax

Diseases related to Amaurosis Fugax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
id Related Disease Score Top Affiliating Genes
1 transient cerebral ischemia 11.4
2 mini stroke 11.1
3 retinitis 10.4
4 cerebritis 10.2
5 stt3a-cdg and stt3b-cdg 10.2 F5 SERPINE1
6 neuroaxonal dystrophy 10.2 F5 SERPINE1
7 inherited blood coagulation disease 10.1 F5 SERPINE1
8 microphthalmia, isolated, with coloboma 10 10.1 F5 SERPINE1
9 czech dysplasia 10.1 F5 SERPINE1
10 carotid artery disease 10.1
11 artery disease 10.1
12 mental retardation hypotonia skin hyperpigmentation 10.1 F5 SERPINE1
13 brill-zinsser disease 10.1 F5 SERPINE1
14 retinal artery occlusion 10.1
15 lupus erythematosus 10.1
16 thrombophilia 10.1
17 headache 10.1
18 exophthalmic ophthalmoplegia 10.1 F5 MMP9
19 leukoplakia of vagina 10.1 MMP8 MMP9
20 renal oncocytoma 10.1 MMP8 MMP9
21 burns 10.1 MMP8 MMP9
22 infancy electroclinical syndrome 10.1 MMP8 MMP9
23 maxillary sinus cholesteatoma 10.0 MMP8 MMP9
24 multiple familial trichoepithelioma 10.0 F5 MTHFR
25 vascular erectile tumor 10.0 F5 MTHFR
26 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.0 F5 MTHFR
27 lung cancer 10.0 F5 MTHFR
28 hypertrichosis 10.0 F5 MTHFR
29 stenosis of lacrimal sac 10.0 MMP8 MMP9
30 left-right axis malformations 10.0 F5 MTHFR
31 myosclerosis, congenital 10.0 F5 MTHFR
32 photosensitive epilepsy 10.0 F5 MTHFR
33 optic nerve neoplasm 10.0 MMP8 MMP9
34 cryptosporidiosis 10.0 F5 MTHFR
35 angular blepharoconjunctivitis 10.0 F5 MTHFR
36 houlston ironton temple syndrome 10.0 F5 MTHFR
37 unilateral hypoactive labyrinth 10.0 MMP8 MMP9
38 blepharoconjunctivitis 10.0 F5 MTHFR
39 gastrointestinal defects and immunodeficiency syndrome 10.0 F5 MTHFR
40 villous adenoma 10.0 F5 MTHFR
41 neutropenia 10.0 MTHFR SERPINE1
42 ophthalmia neonatorum 10.0 F5 MTHFR
43 vaginal discharge 10.0 F5 MTHFR
44 alcoholic gastritis 10.0 F5 MTHFR
45 vascular dementia 10.0 MMP8 MMP9
46 thrombophilia due to activated protein c resistance 10.0 F5 MTHFR
47 glutathionuria 10.0 MTHFR SERPINE1
48 spinal multifocal clear cell meningioma 10.0 F5 MTHFR
49 arcus senilis 10.0 MTHFR SERPINE1
50 endotheliitis 10.0

Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to Amaurosis Fugax

Symptoms & Phenotypes for Amaurosis Fugax

MGI Mouse Phenotypes related to Amaurosis Fugax:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 F5 MMP8 MMP9 MTHFR SERPINE1
2 integument MP:0010771 8.92 F5 MMP9 MTHFR SERPINE1

Drugs & Therapeutics for Amaurosis Fugax

Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
2 diuretics Phase 2
3 Natriuretic Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02) Recruiting NCT01645306 Phase 2
2 Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy Completed NCT01445613
3 Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT) Completed NCT00402740
4 Reproducibility Study of Transcranial Doppler Recruiting NCT03050567

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

Genetic tests related to Amaurosis Fugax:

id Genetic test Affiliating Genes
1 Amaurosis Fugax 29

Anatomical Context for Amaurosis Fugax

MalaCards organs/tissues related to Amaurosis Fugax:

39
Eye, Endothelial, Prostate, Pituitary

Publications for Amaurosis Fugax

Articles related to Amaurosis Fugax:

(show top 50) (show all 192)
id Title Authors Year
1
Amaurosis fugax associated with congenital vascular defect. ( 27445507 )
2016
2
Amaurosis fugax - delay between symptoms and surgery by specialty. ( 27895459 )
2016
3
Amaurosis fugax: risk factors and prevalence of significant carotid stenosis. ( 27826182 )
2016
4
IMAGES IN CLINICAL MEDICINE. Amaurosis Fugax Caused by a Branch Retinal Artery Embolus. ( 26605943 )
2015
5
Amaurosis Fugax Captured During Fluorescein Angiography. ( 26049618 )
2015
6
Amaurosis Fugax, Anterior Ischemic Optic Neuropathy and Cilioretinal Artery Occlusion Secondary to Giant Cell Arteritis. ( 26234004 )
2015
7
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. ( 25613128 )
2015
8
Vasospastic Amaurosis Fugax Diagnosed by Cerebral Angiography. ( 26283520 )
2015
9
A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax. ( 26438683 )
2015
10
Headache and amaurosis fugax in an obese woman. ( 26627820 )
2015
11
Recurrent amaurosis fugax and hemichorea: limb-shaking TIA. ( 25617405 )
2015
12
Young patient with headache and amaurosis fugax. ( 24193794 )
2014
13
A traveling "spot sign" in recurrent amaurosis fugax and central retinal artery occlusion. ( 24957310 )
2014
14
Amaurosis fugax caused by neurocysticercosis. ( 24632665 )
2014
15
AMAUROSIS FUGAX IN OCULAR VASCULAR OCCLUSIVE DISORDERS: Prevalence and Pathogeneses. ( 23632956 )
2014
16
ECG of the Month: Amaurosis Fugax in a 45-Year-Old Woman. ( 25075509 )
2014
17
Takayasu retinopathy presenting as amaurosis fugax in a young patient. ( 25390509 )
2013
18
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. ( 23568216 )
2013
19
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. ( 23365782 )
2013
20
Serial carotid MRI identifies rupture of a vulnerable plaque resulting in amaurosis fugax. ( 23509049 )
2013
21
Does amaurosis fugax after retrobulbar injection need any treatment? ( 23595404 )
2013
22
Cervical rib resulting in amaurosis fugax and stroke. ( 24035686 )
2013
23
An unusual case of amaurosis fugax due to papillary fibroelastoma of cor triatriatum. ( 21831902 )
2012
24
Recurrent amaurosis fugax in a patient after stanford type a dissection depending on blood pressure and haemoglobin level. ( 23198268 )
2012
25
Patent foramen ovale presenting with amaurosis fugax. ( 23472288 )
2012
26
Don't forget amaurosis fugax. ( 21690157 )
2011
27
Sleep-induced amaurosis fugax. ( 21723066 )
2011
28
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. ( 21302720 )
2010
29
Monocular amaurosis fugax as the heralding symptom of vasovagal syncope. ( 20434591 )
2010
30
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. ( 20934672 )
2010
31
Diagnosing amaurosis fugax with emergency ultrasound. ( 20015107 )
2010
32
Amaurosis fugax caused by hereditary thrombophilia due to mutation of gene. ( 19507653 )
2009
33
Optic neuritis presenting with amaurosis fugax. ( 19727900 )
2009
34
From amaurosis fugax to asymptomatic bithalamic infarct. ( 19252800 )
2009
35
Time to carotid endarterectomy. Don't forget amaurosis fugax. ( 19564188 )
2009
36
Common carotid artery stenosis and amaurosis fugax. ( 18190813 )
2008
37
Novel mouse model of monocular amaurosis fugax. ( 17975099 )
2007
38
Amaurosis fugax caused by retinal artery vasospasm. Case illustration. ( 17542546 )
2007
39
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. ( 17456620 )
2007
40
Amaurosis fugax secondary to imaging methods of MRI scan. ( 17178375 )
2007
41
Recurrent anterior chamber hemorrhage from an intraocular lens simulating amaurosis fugax. ( 17662452 )
2007
42
Endoscopic epinephrine injection induced amaurosis fugax. ( 16911707 )
2006
43
Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients. ( 16376194 )
2005
44
Amaurosis fugax: associations with heritable thrombophilia. ( 16015408 )
2005
45
Do complaints of amaurosis fugax and blurred vision after transcatheter device closure of atrial septal defect indicate microemboli to retinal vessels? ( 15788050 )
2005
46
Do complaints of amaurosis fugax and blurred vision after transcatheter device closure of atrial septal defect indicate microemboli to retinal vessels? ( 16137504 )
2005
47
Ventricular tachycardia and amaurosis fugax following inadvertent left ventricular pacing. ( 15771935 )
2005
48
A case of frequently recurring amaurosis fugax with atherothrombotic ophthalmic artery occlusion. ( 14718711 )
2004
49
Ulcerated aortic atheromatous plaque causing amaurosis fugax. ( 12677290 )
2003
50
Use of orbital color Doppler imaging for detecting internal carotid artery stenosis in patients with amaurosis fugax. ( 12782164 )
2003

Variations for Amaurosis Fugax

Expression for Amaurosis Fugax

Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for Amaurosis Fugax

Pathways related to Amaurosis Fugax according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 MMP8 MMP9 SERPINE1
2 11.3 MMP9 SERPINE1
3
Show member pathways
11.15 MMP8 MMP9
4 10.41 MMP9 SERPINE1

GO Terms for Amaurosis Fugax

Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 F5 MMP8 MMP9 SERPINE1
2 platelet alpha granule lumen GO:0031093 9.26 F5 SERPINE1
3 tertiary granule lumen GO:1904724 8.96 MMP8 MMP9
4 extracellular matrix GO:0031012 8.8 MMP8 MMP9 SERPINE1

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.54 F5 MMP8 MMP9
2 platelet degranulation GO:0002576 9.32 F5 SERPINE1
3 extracellular matrix disassembly GO:0022617 9.26 MMP8 MMP9
4 collagen catabolic process GO:0030574 9.16 MMP8 MMP9
5 blood circulation GO:0008015 8.96 F5 MTHFR
6 endodermal cell differentiation GO:0035987 8.62 MMP8 MMP9

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.96 MMP8 MMP9
2 serine-type endopeptidase activity GO:0004252 8.8 F5 MMP8 MMP9

Sources for Amaurosis Fugax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....