MCID: AMR003
MIFTS: 38

Amaurosis Fugax malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Amaurosis Fugax

About this section

Aliases & Descriptions for Amaurosis Fugax:

Name: Amaurosis Fugax 46 25
 
Transient Monocular Blindness 46

Classifications:



External Ids:

ICD1028 G45.3

Summaries for Amaurosis Fugax

About this section
Wikipedia:69 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

MalaCards based summary: Amaurosis Fugax, also known as transient monocular blindness, is related to thrombophilia and transient cerebral ischemia. An important gene associated with Amaurosis Fugax is F5 (Coagulation Factor V), and among its related pathways are Matrix Metalloproteinases and Complement and coagulation cascades. Affiliated tissues include eye, endothelial and pituitary, and related mouse phenotypes are integument and homeostasis/metabolism.

Related Diseases for Amaurosis Fugax

About this section

Diseases related to Amaurosis Fugax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia30.7F5, MTHFR
2transient cerebral ischemia10.7
3retinitis10.5
4michels caskey syndrome10.3F5, MTHFR
5subcortical arteriosclerotic encephalopathy10.3F5, MTHFR
6acute zonal occult outer retinopathy10.3F5, MTHFR
7thyroid hyalinizing trabecular adenoma10.3F5, MTHFR
8cerebritis10.3
9pregnancy loss, recurrent 110.3F5, MTHFR
10homocystinuria due to defect in methylation cbl g10.3F5, MTHFR
11left-right axis malformations10.3F5, MTHFR
12primary pigmented nodular adrenocortical disease10.3F5, MTHFR
13budd-chiari syndrome10.3F5, MTHFR
14hepatocellular adenoma10.3F5, MTHFR
15urinary bladder cancer10.3F5, MTHFR
16angular blepharoconjunctivitis10.3F5, MTHFR
17pseudohermaphroditism10.3F5, MTHFR
18noma10.3F5, MTHFR
19artery disease10.3
20carotid artery disease10.3
21joint disorders10.3F5, MTHFR
22lip carcinoma in situ10.3F5, MTHFR
23spastic paraplegia 3a10.2F5, MTHFR
24thrombocytopenia with elevated serum iga and renal disease10.2F5, MTHFR
25schizencephaly10.2F5, MTHFR
26choroid necrotic melanoma10.2F5, MTHFR
27retinal artery occlusion10.2
28lupus erythematosus10.2
29headache10.2
30mini stroke10.2
31borderline glaucoma10.2F5, MTHFR
32inflammatory liposarcoma10.1MMP8, MMP9
33photokeratitis10.1F5, MTHFR
34systemic lupus erythematosus10.1
35arteriovenous fistula10.1
36atherosclerosis10.1
37arteriovenous malformation10.1
38central retinal artery occlusion10.1
39carotid artery occlusion10.1
40vasculitis10.1
41neuropathy10.1
42endotheliitis10.1
43chorioretinitis10.1MMP8, MMP9
44frontal sinus cancer10.1F5, MTHFR
45iritis10.1MMP9, MTHFR
46charcot-marie-tooth disease10.1F5, MTHFR
47integumentary system cancer10.1MMP8, MMP9
48neonatal period electroclinical syndrome10.1MMP8, MMP9
49oral lichen planus10.0MMP9, MTHFR
50nervous system cancer10.0MMP8, MMP9

Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to amaurosis fugax

Symptoms for Amaurosis Fugax

About this section

Drugs & Therapeutics for Amaurosis Fugax

About this section

Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MannitolPhase 225769-65-8453, 6251
Synonyms:
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
(L)-Mannitol
1,2,3,4,5,6-Hexanehexol
123897-58-5
133-43-7
15719_ALDRICH
15719_RIEDEL
33440_RIEDEL
33440_SIGMA
36413-61-3
4-01-00-02841 (Beilstein Handbook Reference)
5149-40-6
63559_FLUKA
63559_SIGMA
63560_FLUKA
63565_FLUKA
63565_SIGMA
69-65-8
75398-80-0
85085-15-0
87-78-5
AB1002081
AC-12776
AC1L1M49
AC1Q28E5
AI3-19511
AR-1J3861
Ambap69-65-8
BRN 1721898
C00392
C6H14O6
CCRIS 369
CHEBI:16899
CHEMBL689
CID6251
Cordycepate
Cordycepic acid
D-(-)-Mannitol
D-Mannitol
D-Mannitol (JP15)
D-mannite
D-mannitol
D00062
D008353
DL-Mannitol
Diosmol
ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D
EINECS 200-711-8
EINECS 201-770-2
Fraxinine
HSDB 714
Hexahydroxyhexane
Hexanhexol
Invenex
Isotol
LS-1588
LS-89250
M0044
M1902_SIGMA
M4125_SIAL
M8429_SIAL
M9546_SIAL
M9647_SIAL
MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
 
MANNITOL 25%
MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
MLS001335977
MLS001335978
MTL
Manicol
Manitol
Maniton S
Maniton-S
Manna Sugar
Manna sugar
Mannazucker
Mannidex
Mannidex 16700
Mannigen
Mannistol
Mannit
Mannit p
Mannite
Mannitol
Mannitol (USP)
Mannitol (VAN)
Mannitol 10%
Mannitol 10% In Plastic Container
Mannitol 15%
Mannitol 15% In Plastic Container
Mannitol 20%
Mannitol 20% In Plastic Container
Mannitol 5%
Mannitol 5% In Plastic Container
Mannitol [USAN]
Mannitolum
Mannogem 2080
Marine Crystal
Marine crystal
MolPort-003-927-039
Mushroom sugar
NCGC00164246-01
NCI-C50362
NSC 407017
NSC 9256
OSMITROL 10% IN WATER IN PLASTIC CONTAINER
OSMITROL 15% IN WATER IN PLASTIC CONTAINER
OSMITROL 20% IN WATER IN PLASTIC CONTAINER
OSMITROL 5% IN WATER IN PLASTIC CONTAINER
Osmitrol
Osmitrol (TN)
Osmitrol 10% In Water
Osmitrol 15% In Water
Osmitrol 20% In Water
Osmitrol 5% In Water
Osmofundin
Osmosal
Resectisol
Resectisol In Plastic Container
SDM No. 35
SMR000857324
SORBITOL-MANNITOL IN PLASTIC CONTAINER
Sorbitol-Mannitol
TL806434
UNII-3OWL53L36A
ZINC02041302
bmse000099
cpd without stereochemical designation
e 421
e-421
e421
manita
mannitol
2diureticsPhase 21338

Interventional clinical trials:

idNameStatusNCT IDPhase
1Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)RecruitingNCT01645306Phase 2
2Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid EndarterectomyCompletedNCT01445613
3Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT)CompletedNCT00402740

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

About this section

Genetic tests related to Amaurosis Fugax:

id Genetic test Affiliating Genes
1 Amaurosis Fugax25

Anatomical Context for Amaurosis Fugax

About this section

MalaCards organs/tissues related to Amaurosis Fugax:

34
Eye, Endothelial, Pituitary, Prostate

Animal Models for Amaurosis Fugax or affiliated genes

About this section

MGI Mouse Phenotypes related to Amaurosis Fugax:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3F5, MMP9, MTHFR, SERPINE1
2MP:00053767.5F5, MMP8, MMP9, MTHFR, SERPINE1

Publications for Amaurosis Fugax

About this section

Articles related to Amaurosis Fugax:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Amaurosis fugax associated with congenital vascular defect. (27445507)
2016
2
A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax. (26438683)
2015
3
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. (25613128)
2015
4
Amaurosis fugax caused by neurocysticercosis. (24632665)
2014
5
A traveling "spot sign" in recurrent amaurosis fugax and central retinal artery occlusion. (24957310)
2014
6
Young patient with headache and amaurosis fugax. (24193794)
2014
7
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. (23568216)
2013
8
Does amaurosis fugax after retrobulbar injection need any treatment? (23595404)
2013
9
Patent foramen ovale presenting with amaurosis fugax. (23472288)
2012
10
Sleep-induced amaurosis fugax. (21723066)
2011
11
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. (21302720)
2010
12
From amaurosis fugax to asymptomatic bithalamic infarct. (19252800)
2009
13
Amaurosis fugax secondary to imaging methods of MRI scan. (17178375)
2007
14
Do complaints of amaurosis fugax and blurred vision after transcatheter device closure of atrial septal defect indicate microemboli to retinal vessels? (16137504)
2005
15
Exercise-induced vasospastic amaurosis fugax. (11831932)
2002
16
Wegener's granulomatosis presenting with amaurosis fugax. (12194103)
2002
17
Light-induced amaurosis fugax. (11336956)
2001
18
Vertigo and amaurosis fugax secondary to Takayasu's arteritis. (11459913)
2001
19
Clinical and pathophysiological features of amaurosis fugax in Japanese stroke patients. (10732827)
2000
20
The prognosis of amaurosis fugax and hemispheric transient ischemic attacks. (10396657)
1999
21
Vasospastic amaurosis fugax. (10565534)
1999
22
Takayasu arteritis presenting as amaurosis fugax in a man. (9517701)
1998
23
Amaurosis fugax on standing and angle-closure glaucoma with clomipramine. (8618496)
1996
24
Vasospastic amaurosis fugax in a patient with overlap collagenosis treated with nimodipine. (7746345)
1995
25
Amaurosis fugax as a symptom of carotid artery stenosis. Its relationship with ulcerated plaque. (8120072)
1994
26
Jaw claudication and amaurosis fugax secondary to atheromatous disease of the carotid arteries. (8019808)
1994
27
Amaurosis fugax: prognosis and the role of acetylsalicylic acid. (7922849)
1994
28
Amaurosis fugax. (8259182)
1994
29
Carotid endarterectomy and its alternatives in managing amaurosis fugax. (1743894)
1991
30
The natural history of amaurosis fugax with minor degrees of internal carotid artery stenosis. (2297474)
1990
31
Current management of amaurosis fugax. The Amaurosis Fugax Study Group. (2406992)
1990
32
Dynamic amaurosis fugax secondary to compression of vertebral artery. (3044227)
1988
33
Amaurosis fugax and thrombocythemia. (3683889)
1987
34
Carotid endarterectomy for amaurosis fugax without angiography. (3526933)
1986
35
Reversible monocular cataract simulating amaurosis fugax. (4037603)
1985
36
Mortality and stroke after amaurosis fugax. (4045484)
1985
37
Peripheral arterial occlusion and amaurosis fugax as the first manifestation of polycythemia vera. A case report. (6697006)
1984
38
Radiation induced amaurosis fugax. (6707454)
1984
39
Dual isotope carotid scintigraphy in patients with amaurosis fugax attacks. (6437824)
1984
40
Amaurosis fugax. A unselected material. (6637419)
1983
41
Malposition of a transvenous cardiac electrode associated with amaurosis fugax. (6188115)
1983
42
Bilateral and simultaneous amaurosis fugax. (7097020)
1982
43
Amaurosis fugax. (6122063)
1982
44
Evidence of silent cerebral embolism in patients with amaurosis fugax. (915508)
1977
45
Amaurosis fugax. (847787)
1977
46
Carotid artery surgery and intermittent monocular blindness (amaurosis fugax). (4501615)
1972
47
Effect of drugs that suppress platelet surface interaction on incidence of amaurosis fugax and transient cerebral ishcemia. (4601078)
1972
48
Effect of aspirin in amaurosis fugax. (4106235)
1971
49
Amaurosis fugax: a specific type of transient loss of vision. (13398129)
1957
50
Amaurosis fugax et amaurosis fulminans. (14818501)
1951

Variations for Amaurosis Fugax

About this section

Expression for genes affiliated with Amaurosis Fugax

About this section
Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for genes affiliated with Amaurosis Fugax

About this section

GO Terms for genes affiliated with Amaurosis Fugax

About this section

Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.8F5, SERPINE1
2extracellular spaceGO:00056158.1F5, MMP8, MMP9, SERPINE1
3extracellular regionGO:00055767.8F5, MMP8, MMP9, SERPINE1

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endodermal cell differentiationGO:00359879.7MMP8, MMP9
2blood circulationGO:00080159.5F5, MTHFR
3platelet degranulationGO:00025769.4F5, SERPINE1
4collagen catabolic processGO:00305749.3MMP8, MMP9
5extracellular matrix disassemblyGO:00226179.0MMP8, MMP9

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.7MMP8, MMP9
2serine-type endopeptidase activityGO:00042528.9F5, MMP8, MMP9

Sources for Amaurosis Fugax

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet