MCID: AMR003
MIFTS: 37

Amaurosis Fugax

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Amaurosis Fugax

MalaCards integrated aliases for Amaurosis Fugax:

Name: Amaurosis Fugax 50 29
Transient Monocular Blindness 50

Classifications:



External Ids:

ICD10 33 G45.3

Summaries for Amaurosis Fugax

MalaCards based summary : Amaurosis Fugax, also known as transient monocular blindness, is related to neuropathy and syncope. An important gene associated with Amaurosis Fugax is F5 (Coagulation Factor V), and among its related pathways/superpathways are Degradation of the extracellular matrix and Adhesion. The drugs Mannitol and diuretics have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and pituitary, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 72 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

Related Diseases for Amaurosis Fugax

Diseases related to Amaurosis Fugax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
id Related Disease Score Top Affiliating Genes
1 neuropathy 29.9 MMP8 MMP9
2 syncope 29.8 F5 MTHFR
3 transient cerebral ischemia 11.4
4 mini stroke 11.1
5 retinitis 10.4
6 stoll alembik finck syndrome 10.4 F5 SERPINE1
7 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.3 F5 SERPINE1
8 mental retardation dysmorphism hypogonadism diabetes 10.3 F5 SERPINE1
9 neuroaxonal dystrophy 10.3 F5 SERPINE1
10 stickler sydrome, type i, nonsyndromic ocular 10.3 F5 SERPINE1
11 inherited blood coagulation disease 10.3 F5 SERPINE1
12 cerebritis 10.2
13 brill-zinsser disease 10.2 F5 SERPINE1
14 lower clivus meningioma 10.2 MMP8 MMP9
15 artery disease 10.1
16 carotid artery disease 10.1
17 pityriasis rosea 10.1 MMP8 MMP9
18 exophthalmic ophthalmoplegia 10.1 F5 MMP9
19 thrombophilia 10.1
20 retinal artery occlusion 10.1
21 lupus erythematosus 10.1
22 headache 10.1
23 burn scar 10.1 MMP8 MMP9
24 pulmonary sarcoidosis 10.1 MMP8 MMP9
25 multicentric osteolysis nephropathy 10.1 F5 MTHFR
26 hodgkin's lymphoma, mixed cellularity 10.1 MMP8 MMP9
27 glossopharyngeal nerve disease 10.1 MMP8 MMP9
28 superior limbic keratoconjunctivitis 10.0 F5 MTHFR
29 follicular adenoma 10.0 F5 MTHFR
30 pregnancy loss, recurrent 1 10.0 F5 MTHFR
31 hiv-1 10.0 F5 MTHFR
32 primary pigmented nodular adrenocortical disease 10.0 F5 MTHFR
33 neonatal period electroclinical syndrome 10.0 MMP8 MMP9
34 femoral neuropathy 10.0 F5 MTHFR
35 cryptosporidiosis 10.0 F5 MTHFR
36 homologous wasting disease 10.0 F5 MTHFR
37 angular blepharoconjunctivitis 10.0 F5 MTHFR
38 sheehan syndrome 10.0 MMP8 MMP9
39 hepatocellular adenoma 10.0 F5 MTHFR
40 systemic lupus erythematosus 10.0
41 arteriovenous fistula 10.0
42 atherosclerosis 10.0
43 arteriovenous malformation 10.0
44 carotid stenosis 10.0
45 central retinal artery occlusion 10.0
46 carotid artery occlusion 10.0
47 vasculitis 10.0
48 endotheliitis 10.0
49 germ cell and embryonal cancer 10.0 MMP8 MMP9
50 ulcerative stomatitis 10.0 F5 MTHFR

Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to Amaurosis Fugax

Symptoms & Phenotypes for Amaurosis Fugax

MGI Mouse Phenotypes related to Amaurosis Fugax:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 F5 MMP8 MMP9 MTHFR SERPINE1
2 integument MP:0010771 8.92 F5 MMP9 MTHFR SERPINE1

Drugs & Therapeutics for Amaurosis Fugax

Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
2 diuretics Phase 2
3 Natriuretic Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02) Recruiting NCT01645306 Phase 2 Revacept;Placebo
2 Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy Completed NCT01445613
3 Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT) Completed NCT00402740
4 Reproducibility Study of Transcranial Doppler Recruiting NCT03050567

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

Genetic tests related to Amaurosis Fugax:

id Genetic test Affiliating Genes
1 Amaurosis Fugax 29

Anatomical Context for Amaurosis Fugax

MalaCards organs/tissues related to Amaurosis Fugax:

39
Eye, Endothelial, Pituitary, Prostate

Publications for Amaurosis Fugax

Articles related to Amaurosis Fugax:

(show top 50) (show all 193)
id Title Authors Year
1
Lights Out: an Unusual Case of Amaurosis Fugax. ( 28917646 )
2017
2
Amaurosis fugax - delay between symptoms and surgery by specialty. ( 27895459 )
2016
3
Amaurosis fugax associated with congenital vascular defect. ( 27445507 )
2016
4
Amaurosis fugax: risk factors and prevalence of significant carotid stenosis. ( 27826182 )
2016
5
Amaurosis Fugax Captured During Fluorescein Angiography. ( 26049618 )
2015
6
Amaurosis Fugax, Anterior Ischemic Optic Neuropathy and Cilioretinal Artery Occlusion Secondary to Giant Cell Arteritis. ( 26234004 )
2015
7
Recurrent amaurosis fugax and hemichorea: limb-shaking TIA. ( 25617405 )
2015
8
Vasospastic Amaurosis Fugax Diagnosed by Cerebral Angiography. ( 26283520 )
2015
9
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. ( 25613128 )
2015
10
A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax. ( 26438683 )
2015
11
IMAGES IN CLINICAL MEDICINE. Amaurosis Fugax Caused by a Branch Retinal Artery Embolus. ( 26605943 )
2015
12
Headache and amaurosis fugax in an obese woman. ( 26627820 )
2015
13
Young patient with headache and amaurosis fugax. ( 24193794 )
2014
14
A traveling "spot sign" in recurrent amaurosis fugax and central retinal artery occlusion. ( 24957310 )
2014
15
ECG of the Month: Amaurosis Fugax in a 45-Year-Old Woman. ( 25075509 )
2014
16
AMAUROSIS FUGAX IN OCULAR VASCULAR OCCLUSIVE DISORDERS: Prevalence and Pathogeneses. ( 23632956 )
2014
17
Amaurosis fugax caused by neurocysticercosis. ( 24632665 )
2014
18
Takayasu retinopathy presenting as amaurosis fugax in a young patient. ( 25390509 )
2013
19
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. ( 23365782 )
2013
20
Cervical rib resulting in amaurosis fugax and stroke. ( 24035686 )
2013
21
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. ( 23568216 )
2013
22
Does amaurosis fugax after retrobulbar injection need any treatment? ( 23595404 )
2013
23
Serial carotid MRI identifies rupture of a vulnerable plaque resulting in amaurosis fugax. ( 23509049 )
2013
24
Patent foramen ovale presenting with amaurosis fugax. ( 23472288 )
2012
25
An unusual case of amaurosis fugax due to papillary fibroelastoma of cor triatriatum. ( 21831902 )
2012
26
Recurrent amaurosis fugax in a patient after stanford type a dissection depending on blood pressure and haemoglobin level. ( 23198268 )
2012
27
Sleep-induced amaurosis fugax. ( 21723066 )
2011
28
Don't forget amaurosis fugax. ( 21690157 )
2011
29
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. ( 21302720 )
2010
30
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. ( 20934672 )
2010
31
Monocular amaurosis fugax as the heralding symptom of vasovagal syncope. ( 20434591 )
2010
32
Diagnosing amaurosis fugax with emergency ultrasound. ( 20015107 )
2010
33
Time to carotid endarterectomy. Don't forget amaurosis fugax. ( 19564188 )
2009
34
Optic neuritis presenting with amaurosis fugax. ( 19727900 )
2009
35
Amaurosis fugax caused by hereditary thrombophilia due to mutation of gene. ( 19507653 )
2009
36
From amaurosis fugax to asymptomatic bithalamic infarct. ( 19252800 )
2009
37
Common carotid artery stenosis and amaurosis fugax. ( 18190813 )
2008
38
Amaurosis fugax secondary to imaging methods of MRI scan. ( 17178375 )
2007
39
Novel mouse model of monocular amaurosis fugax. ( 17975099 )
2007
40
Recurrent anterior chamber hemorrhage from an intraocular lens simulating amaurosis fugax. ( 17662452 )
2007
41
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. ( 17456620 )
2007
42
Amaurosis fugax caused by retinal artery vasospasm. Case illustration. ( 17542546 )
2007
43
Endoscopic epinephrine injection induced amaurosis fugax. ( 16911707 )
2006
44
Amaurosis fugax: associations with heritable thrombophilia. ( 16015408 )
2005
45
Do complaints of amaurosis fugax and blurred vision after transcatheter device closure of atrial septal defect indicate microemboli to retinal vessels? ( 15788050 )
2005
46
Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients. ( 16376194 )
2005
47
Do complaints of amaurosis fugax and blurred vision after transcatheter device closure of atrial septal defect indicate microemboli to retinal vessels? ( 16137504 )
2005
48
Ventricular tachycardia and amaurosis fugax following inadvertent left ventricular pacing. ( 15771935 )
2005
49
A case of frequently recurring amaurosis fugax with atherothrombotic ophthalmic artery occlusion. ( 14718711 )
2004
50
Vasospastic amaurosis fugax. ( 12531936 )
2003

Variations for Amaurosis Fugax

Expression for Amaurosis Fugax

Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for Amaurosis Fugax

Pathways related to Amaurosis Fugax according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 MMP8 MMP9 SERPINE1
2 11.3 MMP9 SERPINE1
3
Show member pathways
11.15 MMP8 MMP9
4 10.41 MMP9 SERPINE1

GO Terms for Amaurosis Fugax

Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 F5 MMP8 MMP9 SERPINE1
2 platelet alpha granule lumen GO:0031093 9.16 F5 SERPINE1
3 tertiary granule lumen GO:1904724 8.96 MMP8 MMP9
4 extracellular matrix GO:0031012 8.8 MMP8 MMP9 SERPINE1

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.32 F5 SERPINE1
2 extracellular matrix disassembly GO:0022617 9.26 MMP8 MMP9
3 collagen catabolic process GO:0030574 9.16 MMP8 MMP9
4 blood circulation GO:0008015 8.96 F5 MTHFR
5 endodermal cell differentiation GO:0035987 8.62 MMP8 MMP9

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.62 MMP8 MMP9

Sources for Amaurosis Fugax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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