MCID: AMR003
MIFTS: 28

Amaurosis Fugax malady

Neuronal diseases category

Summaries for Amaurosis Fugax

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63Wikipedia, 32MalaCards
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Wikipedia:63 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

MalaCards: Amaurosis Fugax, also known as transient monocular blindness, is related to lupus erythematosus and migraine. An important gene associated with Amaurosis Fugax is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Cell adhesion ECM remodeling and Complement and coagulation cascades. The compounds warfarin and coumarins have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Amaurosis Fugax

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42NIH Rare Diseases, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

amaurosis fugax 42
transient monocular blindness 42


External Ids:

ICD1025 G45.3

Related Diseases for Amaurosis Fugax

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to amaurosis fugax

Clinical Features for Amaurosis Fugax

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Drugs & Therapeutics for Amaurosis Fugax

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Amaurosis Fugax

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Anatomical Context for Amaurosis Fugax

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32MalaCards
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MalaCards organs/tissues related to Amaurosis Fugax:

32
Eye

Animal Models for Amaurosis Fugax or affiliated genes

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Publications for Amaurosis Fugax

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Genetic Variations for Amaurosis Fugax

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Expression for genes affiliated with Amaurosis Fugax

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amaurosis Fugax

Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for genes affiliated with Amaurosis Fugax

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Sources:
12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with Amaurosis Fugax

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Amaurosis Fugax according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.4APOH
2coumarins4410.3APOH
3serine4410.0MMP8
4cacl2449.8F5, MMP8
5kaolin449.8APOH, F5
6batroxobin449.7F5, SERPINE1
7ancrod449.7SERPINE1, F5
8Drotrecogin alfa119.7SERPINE1, F5
911-dehydrothromboxane b2449.7APOH, SERPINE1
10phosphatidylethanolamine44 1110.7F5, APOH
11tibolone449.7F5, SERPINE1
12cyproteroneacetate449.6SERPINE1, F5
13desmopressin44 59 28 1112.6SERPINE1, F5
148-isoprostane449.6APOH, SERPINE1
15hirudin449.6SERPINE1, F5
16heparin44 28 11 2412.6APOH, MTHFR
17mycophenolate mofetil44 49 1111.6F5, SERPINE1
18deoxyribonucleic acid449.5APOH, F5
19protamine449.5F5, SERPINE1
205-methyltetrahydrofolate44 1110.5F5, MTHFR
21dextran sulfate449.5APOH, F5
22cystathionine449.5MTHFR, F5
23raloxifene44 28 49 1112.5F5, SERPINE1
24vitamin b6449.4MTHFR, F5
25p00001449.3SERPINE1, MTHFR
26kininogen449.2APOH, F5, SERPINE1
27pge1449.2F5, SERPINE1, APOH
28endotoxin449.2SERPINE1, F5, APOH
29prostacyclin449.2SERPINE1, F5, APOH
30lactate449.2APOH, F5, MMP8
31malondialdehyde449.1F5, APOH
32cyclophosphamide44 49 1111.1APOH, MTHFR, F5
33vitamin b12449.0APOH, F5, MTHFR
34betacarotene449.0APOH, MTHFR
35folate449.0APOH, F5, MTHFR
36metformin44 49 1110.9MTHFR, F5, SERPINE1
37methotrexate44 49 1110.9MTHFR, APOH, SERPINE1
38progesterone44 59 28 11 2412.8SERPINE1, MMP8, APOH, F5
39vegf448.7SERPINE1, MMP8, F5, APOH
40nitric oxide44 11 2410.7SERPINE1, APOH, F5, MMP8
41p002448.6F5, MMP8, MTHFR, APOH
42testosterone44 59 11 2411.5F5, MTHFR, SERPINE1
43uric acid44 249.4F5, APOH, SERPINE1, MTHFR
44homocysteine44 249.4SERPINE1, APOH, F5, MTHFR
45aspirin44 49 28 2411.4MTHFR, APOH, SERPINE1, F5
46creatinine448.4SERPINE1, F5, MTHFR, APOH
47cholesterol44 28 11 2411.4SERPINE1, MTHFR, F5, APOH
48retinoic acid44 249.4F5, SERPINE1, MTHFR, MMP8
49estrogen448.3APOH, F5, SERPINE1, MTHFR
50fibrinogen448.0MTHFR, SERPINE1, MMP8, APOH, F5

GO Terms for genes affiliated with Amaurosis Fugax

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16Gene Ontology
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Cellular components related to Amaurosis Fugax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3SERPINE1, F5
2extracellular spaceGO:0056158.1SERPINE1, MMP8, F5, APOH

Biological processes related to Amaurosis Fugax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.4SERPINE1, APOH
2positive regulation of blood coagulationGO:0301949.3SERPINE1, APOH
3platelet degranulationGO:0025769.3SERPINE1, F5
4negative regulation of blood coagulationGO:0301959.2APOH, SERPINE1
5blood circulationGO:0080158.8MTHFR, F5

Products for genes affiliated with Amaurosis Fugax

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amaurosis Fugax

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet