MCID: AMR003
MIFTS: 30

Amaurosis Fugax malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Amaurosis Fugax

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Aliases & Descriptions for Amaurosis Fugax:

Name: Amaurosis Fugax 45
 
Transient Monocular Blindness 45


Classifications:



External Ids:

ICD1027 G45.3

Summaries for Amaurosis Fugax

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Wikipedia:68 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

MalaCards based summary: Amaurosis Fugax, also known as transient monocular blindness, is related to retinitis and artery disease. An important gene associated with Amaurosis Fugax is F5 (Coagulation Factor V (Proaccelerin, Labile Factor)), and among its related pathways are Matrix Metalloproteinases and Adhesion. Affiliated tissues include eye, endothelial and pituitary, and related mouse phenotype integument.

Related Diseases for Amaurosis Fugax

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Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to amaurosis fugax

Symptoms for Amaurosis Fugax

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Drugs & Therapeutics for Amaurosis Fugax

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Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mannitolapproved, investigationalPhase 222069-65-8453, 6251
Synonyms:
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
(L)-Mannitol
1,2,3,4,5,6-Hexanehexol
123897-58-5
133-43-7
15719_ALDRICH
15719_RIEDEL
33440_RIEDEL
33440_SIGMA
36413-61-3
4-01-00-02841 (Beilstein Handbook Reference)
5149-40-6
63559_FLUKA
63559_SIGMA
63560_FLUKA
63565_FLUKA
63565_SIGMA
69-65-8
75398-80-0
85085-15-0
87-78-5
AB1002081
AC-12776
AC1L1M49
AC1Q28E5
AI3-19511
AR-1J3861
Ambap69-65-8
BRN 1721898
C00392
C6H14O6
CCRIS 369
CHEBI:16899
CHEMBL689
CID6251
Cordycepate
Cordycepic acid
D-(-)-Mannitol
D-Mannitol
D-Mannitol (JP15)
D-mannite
D-mannitol
D00062
D008353
DL-Mannitol
Diosmol
ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D
EINECS 200-711-8
EINECS 201-770-2
Fraxinine
HSDB 714
Hexahydroxyhexane
Hexanhexol
Invenex
Isotol
LS-1588
LS-89250
M0044
M1902_SIGMA
M4125_SIAL
M8429_SIAL
M9546_SIAL
M9647_SIAL
MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
 
MANNITOL 25%
MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
MLS001335977
MLS001335978
MTL
Manicol
Manitol
Maniton S
Maniton-S
Manna Sugar
Manna sugar
Mannazucker
Mannidex
Mannidex 16700
Mannigen
Mannistol
Mannit
Mannit p
Mannite
Mannitol
Mannitol (USP)
Mannitol (VAN)
Mannitol 10%
Mannitol 10% In Plastic Container
Mannitol 15%
Mannitol 15% In Plastic Container
Mannitol 20%
Mannitol 20% In Plastic Container
Mannitol 5%
Mannitol 5% In Plastic Container
Mannitol [USAN]
Mannitolum
Mannogem 2080
Marine Crystal
Marine crystal
MolPort-003-927-039
Mushroom sugar
NCGC00164246-01
NCI-C50362
NSC 407017
NSC 9256
OSMITROL 10% IN WATER IN PLASTIC CONTAINER
OSMITROL 15% IN WATER IN PLASTIC CONTAINER
OSMITROL 20% IN WATER IN PLASTIC CONTAINER
OSMITROL 5% IN WATER IN PLASTIC CONTAINER
Osmitrol
Osmitrol (TN)
Osmitrol 10% In Water
Osmitrol 15% In Water
Osmitrol 20% In Water
Osmitrol 5% In Water
Osmofundin
Osmosal
Resectisol
Resectisol In Plastic Container
SDM No. 35
SMR000857324
SORBITOL-MANNITOL IN PLASTIC CONTAINER
Sorbitol-Mannitol
TL806434
UNII-3OWL53L36A
ZINC02041302
bmse000099
cpd without stereochemical designation
e 421
e-421
e421
manita
mannitol

Interventional clinical trials:

idNameStatusNCT IDPhase
1Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)RecruitingNCT01645306Phase 2
2Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT)CompletedNCT00402740
3Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid EndarterectomyActive, not recruitingNCT01445613

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Genetic Tests for Amaurosis Fugax

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Anatomical Context for Amaurosis Fugax

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MalaCards organs/tissues related to Amaurosis Fugax:

33
Eye, Endothelial, Pituitary, Prostate

Animal Models for Amaurosis Fugax or affiliated genes

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MGI Mouse Phenotypes related to Amaurosis Fugax:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1F5, MMP9, MTHFR, SERPINE1

Publications for Amaurosis Fugax

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Articles related to Amaurosis Fugax:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Recurrent amaurosis fugax and hemichorea: limb-shaking TIA. (25617405)
2015
2
A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax. (26438683)
2015
3
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. (25613128)
2015
4
Amaurosis fugax caused by neurocysticercosis. (24632665)
2014
5
Cervical rib resulting in amaurosis fugax and stroke. (24035686)
2013
6
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. (23568216)
2013
7
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. (23365782)
2013
8
Does amaurosis fugax after retrobulbar injection need any treatment? (23595404)
2013
9
Patent foramen ovale presenting with amaurosis fugax. (23472288)
2012
10
Sleep-induced amaurosis fugax. (21723066)
2011
11
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. (21302720)
2010
12
Diagnosing amaurosis fugax with emergency ultrasound. (20015107)
2010
13
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. (20934672)
2010
14
Novel mouse model of monocular amaurosis fugax. (17975099)
2007
15
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. (17456620)
2007
16
Exercise-induced vasospastic amaurosis fugax. (11831932)
2002
17
Wegener's granulomatosis presenting with amaurosis fugax. (12194103)
2002
18
Light-induced amaurosis fugax. (11336956)
2001
19
Amaurosis fugax and stenosis of the ophthalmic artery--a case report. (11668383)
2001
20
Vertigo and amaurosis fugax secondary to Takayasu's arteritis. (11459913)
2001
21
The prognosis of amaurosis fugax and hemispheric transient ischemic attacks. (10396657)
1999
22
Takayasu arteritis presenting as amaurosis fugax in a man. (9517701)
1998
23
Amaurosis fugax as a symptom of carotid artery stenosis. Its relationship with ulcerated plaque. (8120072)
1994
24
Jaw claudication and amaurosis fugax secondary to atheromatous disease of the carotid arteries. (8019808)
1994
25
Amaurosis fugax: prognosis and the role of acetylsalicylic acid. (7922849)
1994
26
Brief report: treatment of vasospastic amaurosis fugax with calcium-channel blockers. (8326973)
1993
27
Amaurosis fugax in young people. (1477040)
1992
28
Recurrent attacks of amaurosis fugax treated with calcium channel blocker. (1952830)
1991
29
Carotid endarterectomy and its alternatives in managing amaurosis fugax. (1743894)
1991
30
Amaurosis fugax in a young woman. (1972478)
1990
31
Amaurosis fugax and antiphospholipid antibodies. (1975351)
1990
32
Dynamic amaurosis fugax secondary to compression of vertebral artery. (3044227)
1988
33
Amaurosis fugax in teenagers. A migraine variant. (3344721)
1988
34
Amaurosis fugax in a patient with systemic lupus erythematosus and antiphospholipid antibodies. (3427847)
1987
35
Amaurosis fugax and thrombocythemia. (3683889)
1987
36
Postprandial transient painful amaurosis fugax. (3746361)
1986
37
Amaurosis fugax and retinal vasculitis associated with methamphetamine inhalation. (2934418)
1985
38
Reversible monocular cataract simulating amaurosis fugax. (4037603)
1985
39
Peripheral arterial occlusion and amaurosis fugax as the first manifestation of polycythemia vera. A case report. (6697006)
1984
40
Doppler ultrasound as an adjunct for the investigation of amaurosis fugax. (6385357)
1983
41
Amaurosis fugax for a long duration. (6222083)
1983
42
Amaurosis fugax. (6812749)
1982
43
Demonstration of pathological circulating endothelial cells in patients with amaurosis fugax. (6946628)
1980
44
Peripapillary staphyloma and amaurosis fugax. (900730)
1977
45
Evidence of silent cerebral embolism in patients with amaurosis fugax. (915508)
1977
46
Effect of aspirin in amaurosis fugax. (4108964)
1972
47
Carotid artery surgery and intermittent monocular blindness (amaurosis fugax). (4501615)
1972
48
Effect of aspirin in amaurosis fugax. (4106235)
1971
49
The natural history of monocular amaurosis fugax. (5782087)
1969
50
Amaurosis fugax: a specific type of transient loss of vision. (13398129)
1957

Variations for Amaurosis Fugax

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Expression for genes affiliated with Amaurosis Fugax

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Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for genes affiliated with Amaurosis Fugax

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Pathways related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3MMP8, MMP9
29.3MMP9, SERPINE1
39.3MMP9, SERPINE1
4
Show member pathways
9.1MTHFR, SERPINE1
5
Show member pathways
8.8MMP8, MMP9, SERPINE1

GO Terms for genes affiliated with Amaurosis Fugax

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Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.1F5, SERPINE1
2extracellular matrixGO:00310128.7MMP8, MMP9, SERPINE1
3extracellular spaceGO:00056158.4F5, MMP8, MMP9, SERPINE1
4extracellular regionGO:00055768.1F5, MMP8, MMP9, SERPINE1

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:000257610.0F5, SERPINE1
2endodermal cell differentiationGO:00359879.8MMP8, MMP9
3blood circulationGO:00080159.5F5, MTHFR
4extracellular matrix disassemblyGO:00226179.3MMP8, MMP9
5collagen catabolic processGO:00305749.0MMP8, MMP9
6extracellular matrix organizationGO:00301988.8MMP8, MMP9, SERPINE1

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.4MMP8, MMP9
2metallopeptidase activityGO:00082379.3MMP8, MMP9

Sources for Amaurosis Fugax

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet