MCID: AMR003
MIFTS: 40

Amaurosis Fugax malady

Rare diseases, Neuronal diseases categories

Summaries for Amaurosis Fugax

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66Wikipedia, 34MalaCards
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Wikipedia:66 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

MalaCards: Amaurosis Fugax, also known as transient monocular blindness, is related to lupus erythematosus and retinal artery occlusion. An important gene associated with Amaurosis Fugax is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Cell adhesion ECM remodeling and Formation of Fibrin Clot (Clotting Cascade). The compounds kaolin and cacl2 have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and prostate.

Aliases & Classifications for Amaurosis Fugax

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44NIH Rare Diseases, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

amaurosis fugax 44
transient monocular blindness 44


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ICD1026 G45.3

Related Diseases for Amaurosis Fugax

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to amaurosis fugax

Symptoms for Amaurosis Fugax

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Drugs & Therapeutics for Amaurosis Fugax

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Amaurosis Fugax

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Anatomical Context for Amaurosis Fugax

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34MalaCards
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MalaCards organs/tissues related to Amaurosis Fugax:

34
Eye, Endothelial, Prostate, Pituitary

Animal Models for Amaurosis Fugax or affiliated genes

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Publications for Amaurosis Fugax

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53PubMed
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Articles related to Amaurosis Fugax:

(show top 50)    (show all 176)
idTitleAuthorsYear
1
Cervical rib resulting in amaurosis fugax and stroke. (24035686)
2013
2
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. (23568216)
2013
3
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. (23365782)
2013
4
Does amaurosis fugax after retrobulbar injection need any treatment? (23595404)
2013
5
Patent foramen ovale presenting with amaurosis fugax. (23472288)
2012
6
Sleep-induced amaurosis fugax. (21723066)
2011
7
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. (21302720)
2010
8
Diagnosing amaurosis fugax with emergency ultrasound. (20015107)
2010
9
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. (20934672)
2010
10
Novel mouse model of monocular amaurosis fugax. (17975099)
2007
11
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. (17456620)
2007
12
Exercise-induced vasospastic amaurosis fugax. (11831932)
2002
13
Wegener's granulomatosis presenting with amaurosis fugax. (12194103)
2002
14
Light-induced amaurosis fugax. (11336956)
2001
15
Amaurosis fugax and stenosis of the ophthalmic artery--a case report. (11668383)
2001
16
Vertigo and amaurosis fugax secondary to Takayasu's arteritis. (11459913)
2001
17
Clinical and pathophysiological features of amaurosis fugax in Japanese stroke patients. (10732827)
2000
18
The prognosis of amaurosis fugax and hemispheric transient ischemic attacks. (10396657)
1999
19
Takayasu arteritis presenting as amaurosis fugax in a man. (9517701)
1998
20
Amaurosis fugax as a symptom of carotid artery stenosis. Its relationship with ulcerated plaque. (8120072)
1994
21
Jaw claudication and amaurosis fugax secondary to atheromatous disease of the carotid arteries. (8019808)
1994
22
Amaurosis fugax: prognosis and the role of acetylsalicylic acid. (7922849)
1994
23
Brief report: treatment of vasospastic amaurosis fugax with calcium-channel blockers. (8326973)
1993
24
Amaurosis fugax in young adults. (8343483)
1993
25
Amaurosis fugax in young people. (1477040)
1992
26
Recurrent attacks of amaurosis fugax treated with calcium channel blocker. (1952830)
1991
27
Carotid endarterectomy and its alternatives in managing amaurosis fugax. (1743894)
1991
28
Amaurosis fugax in a young woman. (1972478)
1990
29
Amaurosis fugax and antiphospholipid antibodies. (1975351)
1990
30
Dynamic amaurosis fugax secondary to compression of vertebral artery. (3044227)
1988
31
Amaurosis fugax in teenagers. A migraine variant. (3344721)
1988
32
Amaurosis fugax in a patient with systemic lupus erythematosus and antiphospholipid antibodies. (3427847)
1987
33
Amaurosis fugax and thrombocythemia. (3683889)
1987
34
Protein C deficiency: a cause of amaurosis fugax? (3559620)
1987
35
Postprandial transient painful amaurosis fugax. (3746361)
1986
36
Amaurosis fugax and retinal vasculitis associated with methamphetamine inhalation. (2934418)
1985
37
Reversible monocular cataract simulating amaurosis fugax. (4037603)
1985
38
Mortality and stroke after amaurosis fugax. (4045484)
1985
39
Peripheral arterial occlusion and amaurosis fugax as the first manifestation of polycythemia vera. A case report. (6697006)
1984
40
Doppler ultrasound as an adjunct for the investigation of amaurosis fugax. (6385357)
1983
41
Amaurosis fugax for a long duration. (6222083)
1983
42
Amaurosis fugax. (6812749)
1982
43
Demonstration of pathological circulating endothelial cells in patients with amaurosis fugax. (6946628)
1980
44
Peripapillary staphyloma and amaurosis fugax. (900730)
1977
45
Evidence of silent cerebral embolism in patients with amaurosis fugax. (915508)
1977
46
Effect of aspirin in amaurosis fugax. (4108964)
1972
47
Carotid artery surgery and intermittent monocular blindness (amaurosis fugax). (4501615)
1972
48
Effect of aspirin in amaurosis fugax. (4106235)
1971
49
The natural history of monocular amaurosis fugax. (5782087)
1969
50
Amaurosis fugax: a specific type of transient loss of vision. (13398129)
1957

Variations for Amaurosis Fugax

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Expression for genes affiliated with Amaurosis Fugax

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amaurosis Fugax

Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for genes affiliated with Amaurosis Fugax

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Sources:
51PathCards, 61Thomson Reuters, 13EMD Millipore, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems, 31KEGG
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Pathways related to Amaurosis Fugax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2MMP8, SERPINE1
2
Show member pathways
9.1F5, SERPINE1
3
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.1F5, SERPINE1
4
Show member pathways
9.1F5, SERPINE1
5
Show member pathways
thioredoxin pathway39
9.0SERPINE1, MTHFR

Compounds for genes affiliated with Amaurosis Fugax

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB
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Compounds related to Amaurosis Fugax according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1kaolin469.8APOH, F5
2cacl2469.8MMP8, F5
3coumarins469.8F5, APOH
4cardiolipin46 1210.7F5, APOH
55-methyltetrahydrofolate46 1210.7MTHFR, F5
6cystathionine469.7F5, MTHFR
7phosphatidylethanolamine46 1210.6APOH, F5
8vitamin b6469.6F5, MTHFR
9batroxobin469.5F5, SERPINE1
10ancrod469.5SERPINE1, F5
1111-dehydrothromboxane b2469.5SERPINE1, APOH
12tibolone469.5F5, SERPINE1
13cyproteroneacetate469.5F5, SERPINE1
14deoxyribonucleic acid469.4F5, APOH
15desmopressin46 62 30 1212.4SERPINE1, F5
16malondialdehyde469.4F5, APOH
178-isoprostane469.4SERPINE1, APOH
18hirudin469.4F5, SERPINE1
19p00001469.3MTHFR, SERPINE1
20dextran sulfate469.3F5, APOH
21protamine469.3F5, SERPINE1
22warfarin46 52 25 1212.2APOH, MTHFR, F5
23mycophenolate mofetil46 52 1211.2F5, SERPINE1
24vitamin b12469.2APOH, MTHFR, F5
25lactate469.2F5, MMP8, APOH
26raloxifene46 52 30 1212.2SERPINE1, F5
27folate469.2F5, MTHFR, APOH
28kininogen469.0F5, SERPINE1, APOH
29pge1469.0F5, SERPINE1, APOH
30betacarotene469.0MTHFR, APOH
31endotoxin469.0F5, SERPINE1, APOH
32prostacyclin469.0F5, SERPINE1, APOH
33metformin46 52 1210.9SERPINE1, MTHFR, F5
34methotrexate52 46 1210.9APOH, SERPINE1, MTHFR
35p002468.8F5, MTHFR, MMP8, APOH
36aspartate468.7F5, MTHFR, SERPINE1
37progesterone46 30 62 25 1212.6F5, MMP8, SERPINE1, APOH
38vegf468.6APOH, SERPINE1, MMP8, F5
39nitric oxide46 25 1210.5APOH, SERPINE1, MMP8, F5
40uric acid46 259.4APOH, SERPINE1, MTHFR, F5
41homocysteine46 259.4APOH, SERPINE1, MTHFR, F5
42cyclophosphamide46 52 1210.4APOH, SERPINE1, MTHFR, F5
43aspirin46 52 30 2511.4F5, MTHFR, SERPINE1, APOH
44creatinine468.4APOH, SERPINE1, MTHFR, F5
45heparin46 30 25 1211.4APOH, SERPINE1, MTHFR, F5
46retinoic acid46 259.4F5, MTHFR, MMP8, SERPINE1
47cholesterol46 30 25 1211.4APOH, SERPINE1, MTHFR, F5
48estrogen468.3APOH, SERPINE1, MTHFR, F5
49serine468.3SERPINE1, MMP8, MTHFR, F5
50fibrinogen468.0F5, MTHFR, MMP8, SERPINE1, APOH

GO Terms for genes affiliated with Amaurosis Fugax

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17Gene Ontology
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Cellular components related to Amaurosis Fugax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1SERPINE1, APOH
2platelet alpha granule lumenGO:0310938.8F5, SERPINE1
3extracellular spaceGO:0056158.1F5, MMP8, SERPINE1, APOH

Biological processes related to Amaurosis Fugax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.2SERPINE1, APOH
2positive regulation of blood coagulationGO:0301949.1SERPINE1, APOH
3platelet degranulationGO:0025769.1F5, SERPINE1
4negative regulation of blood coagulationGO:0301959.0APOH, SERPINE1
5blood circulationGO:0080159.0F5, MTHFR

Molecular functions related to Amaurosis Fugax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.5F5, MMP8

Products for genes affiliated with Amaurosis Fugax

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amaurosis Fugax

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet