MCID: AMR003
MIFTS: 41

Amaurosis Fugax malady

Rare diseases, Neuronal diseases categories
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Summaries for Amaurosis Fugax

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Wikipedia:65 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

MalaCards based summary: Amaurosis Fugax, also known as transient monocular blindness, is related to retinal artery occlusion and patent foramen ovale. An important gene associated with Amaurosis Fugax is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Cell adhesion ECM remodeling and Formation of Fibrin Clot (Clotting Cascade). The compounds kaolin and cacl2 have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and prostate.

Aliases & Classifications for Amaurosis Fugax

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Amaurosis Fugax, Aliases & Descriptions:

Name: Amaurosis Fugax 42
 
Transient Monocular Blindness 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

ICD1025 G45.3

Related Diseases for Amaurosis Fugax

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Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to amaurosis fugax

Symptoms for Amaurosis Fugax

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Drugs & Therapeutics for Amaurosis Fugax

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Drug clinical trials:

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Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

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Anatomical Context for Amaurosis Fugax

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MalaCards organs/tissues related to Amaurosis Fugax:

32
Eye, Endothelial, Prostate, Pituitary

Animal Models for Amaurosis Fugax or affiliated genes

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Publications for Amaurosis Fugax

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Articles related to Amaurosis Fugax:

(show top 50)    (show all 178)
idTitleAuthorsYear
1
Amaurosis fugax caused by neurocysticercosis. (24632665)
2014
2
Cervical rib resulting in amaurosis fugax and stroke. (24035686)
2013
3
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. (23568216)
2013
4
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. (23365782)
2013
5
Does amaurosis fugax after retrobulbar injection need any treatment? (23595404)
2013
6
Patent foramen ovale presenting with amaurosis fugax. (23472288)
2012
7
Sleep-induced amaurosis fugax. (21723066)
2011
8
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. (21302720)
2010
9
Diagnosing amaurosis fugax with emergency ultrasound. (20015107)
2010
10
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. (20934672)
2010
11
Novel mouse model of monocular amaurosis fugax. (17975099)
2007
12
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. (17456620)
2007
13
Exercise-induced vasospastic amaurosis fugax. (11831932)
2002
14
Wegener's granulomatosis presenting with amaurosis fugax. (12194103)
2002
15
Light-induced amaurosis fugax. (11336956)
2001
16
Amaurosis fugax and stenosis of the ophthalmic artery--a case report. (11668383)
2001
17
Vertigo and amaurosis fugax secondary to Takayasu's arteritis. (11459913)
2001
18
Clinical and pathophysiological features of amaurosis fugax in Japanese stroke patients. (10732827)
2000
19
The prognosis of amaurosis fugax and hemispheric transient ischemic attacks. (10396657)
1999
20
Takayasu arteritis presenting as amaurosis fugax in a man. (9517701)
1998
21
Amaurosis fugax as a symptom of carotid artery stenosis. Its relationship with ulcerated plaque. (8120072)
1994
22
Jaw claudication and amaurosis fugax secondary to atheromatous disease of the carotid arteries. (8019808)
1994
23
Amaurosis fugax: prognosis and the role of acetylsalicylic acid. (7922849)
1994
24
Brief report: treatment of vasospastic amaurosis fugax with calcium-channel blockers. (8326973)
1993
25
Amaurosis fugax in young adults. (8343483)
1993
26
Amaurosis fugax in young people. (1477040)
1992
27
Carotid endarterectomy and its alternatives in managing amaurosis fugax. (1743894)
1991
28
Amaurosis fugax in a young woman. (1972478)
1990
29
Amaurosis fugax and antiphospholipid antibodies. (1975351)
1990
30
Dynamic amaurosis fugax secondary to compression of vertebral artery. (3044227)
1988
31
Amaurosis fugax in teenagers. A migraine variant. (3344721)
1988
32
Amaurosis fugax in a patient with systemic lupus erythematosus and antiphospholipid antibodies. (3427847)
1987
33
Amaurosis fugax and thrombocythemia. (3683889)
1987
34
Protein C deficiency: a cause of amaurosis fugax? (3559620)
1987
35
Postprandial transient painful amaurosis fugax. (3746361)
1986
36
Amaurosis fugax and retinal vasculitis associated with methamphetamine inhalation. (2934418)
1985
37
Reversible monocular cataract simulating amaurosis fugax. (4037603)
1985
38
Mortality and stroke after amaurosis fugax. (4045484)
1985
39
Peripheral arterial occlusion and amaurosis fugax as the first manifestation of polycythemia vera. A case report. (6697006)
1984
40
Doppler ultrasound as an adjunct for the investigation of amaurosis fugax. (6385357)
1983
41
Amaurosis fugax for a long duration. (6222083)
1983
42
Amaurosis fugax. (6812749)
1982
43
Demonstration of pathological circulating endothelial cells in patients with amaurosis fugax. (6946628)
1980
44
Peripapillary staphyloma and amaurosis fugax. (900730)
1977
45
Evidence of silent cerebral embolism in patients with amaurosis fugax. (915508)
1977
46
Effect of aspirin in amaurosis fugax. (4108964)
1972
47
Carotid artery surgery and intermittent monocular blindness (amaurosis fugax). (4501615)
1972
48
Effect of aspirin in amaurosis fugax. (4106235)
1971
49
The natural history of monocular amaurosis fugax. (5782087)
1969
50
Amaurosis fugax: a specific type of transient loss of vision. (13398129)
1957

Variations for Amaurosis Fugax

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Expression for genes affiliated with Amaurosis Fugax

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Expression patterns in normal tissues for genes affiliated with Amaurosis Fugax

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Pathways for genes affiliated with Amaurosis Fugax

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Pathways related to Amaurosis Fugax according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2MMP8, SERPINE1
2
Show member pathways
9.1F5, SERPINE1
3
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.1F5, SERPINE1
4
Show member pathways
9.1F5, SERPINE1
5
Show member pathways
thioredoxin pathway37
9.0SERPINE1, MTHFR

Compounds for genes affiliated with Amaurosis Fugax

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Compounds related to Amaurosis Fugax according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1kaolin449.8APOH, F5
2cacl2449.8MMP8, F5
3coumarins449.8F5, APOH
4cardiolipin44 1110.7F5, APOH
55-methyltetrahydrofolate44 1110.7MTHFR, F5
6cystathionine449.7F5, MTHFR
7phosphatidylethanolamine44 1110.6APOH, F5
8vitamin b6449.6F5, MTHFR
9batroxobin449.5F5, SERPINE1
10ancrod449.5SERPINE1, F5
1111-dehydrothromboxane b2449.5SERPINE1, APOH
12tibolone449.5F5, SERPINE1
13cyproteroneacetate449.5F5, SERPINE1
14deoxyribonucleic acid449.4F5, APOH
15desmopressin44 61 28 1112.4SERPINE1, F5
16malondialdehyde449.4F5, APOH
178-isoprostane449.4SERPINE1, APOH
18hirudin449.4F5, SERPINE1
19p00001449.3MTHFR, SERPINE1
20dextran sulfate449.3F5, APOH
21protamine449.3F5, SERPINE1
22warfarin44 50 24 1112.2APOH, MTHFR, F5
23mycophenolate mofetil44 50 1111.2F5, SERPINE1
24vitamin b12449.2APOH, MTHFR, F5
25lactate449.2F5, MMP8, APOH
26raloxifene44 50 28 1112.2SERPINE1, F5
27folate449.2F5, MTHFR, APOH
28kininogen449.0F5, SERPINE1, APOH
29pge1449.0F5, SERPINE1, APOH
30betacarotene449.0MTHFR, APOH
31endotoxin449.0F5, SERPINE1, APOH
32prostacyclin449.0F5, SERPINE1, APOH
33metformin44 50 1110.9SERPINE1, MTHFR, F5
34methotrexate50 44 1110.9APOH, SERPINE1, MTHFR
35p002448.8F5, MTHFR, MMP8, APOH
36aspartate448.7F5, MTHFR, SERPINE1
37progesterone44 28 61 24 1112.6F5, MMP8, SERPINE1, APOH
38vegf448.6APOH, SERPINE1, MMP8, F5
39nitric oxide44 24 1110.5APOH, SERPINE1, MMP8, F5
40uric acid44 249.4APOH, SERPINE1, MTHFR, F5
41homocysteine44 249.4APOH, SERPINE1, MTHFR, F5
42cyclophosphamide44 50 1110.4APOH, SERPINE1, MTHFR, F5
43aspirin44 50 28 2411.4F5, MTHFR, SERPINE1, APOH
44creatinine448.4APOH, SERPINE1, MTHFR, F5
45heparin44 28 24 1111.4APOH, SERPINE1, MTHFR, F5
46retinoic acid44 249.4F5, MTHFR, MMP8, SERPINE1
47cholesterol44 28 24 1111.4APOH, SERPINE1, MTHFR, F5
48estrogen448.3APOH, SERPINE1, MTHFR, F5
49serine448.3SERPINE1, MMP8, MTHFR, F5
50fibrinogen448.0F5, MTHFR, MMP8, SERPINE1, APOH

GO Terms for genes affiliated with Amaurosis Fugax

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Cellular components related to Amaurosis Fugax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.1SERPINE1, APOH
2platelet alpha granule lumenGO:0310938.8F5, SERPINE1
3extracellular spaceGO:0056158.1F5, MMP8, SERPINE1, APOH

Biological processes related to Amaurosis Fugax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.2SERPINE1, APOH
2positive regulation of blood coagulationGO:0301949.1SERPINE1, APOH
3platelet degranulationGO:0025769.1F5, SERPINE1
4negative regulation of blood coagulationGO:0301959.0APOH, SERPINE1
5blood circulationGO:0080159.0F5, MTHFR

Molecular functions related to Amaurosis Fugax according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.5F5, MMP8

Products for genes affiliated with Amaurosis Fugax

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Sources for Amaurosis Fugax

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet