MCID: AMR003
MIFTS: 35

Amaurosis Fugax malady

Rare diseases, Neuronal diseases categories

Summaries for Amaurosis Fugax

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Wikipedia:63 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

MalaCards based summary: Amaurosis Fugax, also known as transient monocular blindness, is related to retinal artery occlusion and sneddon syndrome. An important gene associated with Amaurosis Fugax is MMP8 (matrix metallopeptidase 8 (neutrophil collagenase)), and among its related pathways are Cell adhesion ECM remodeling and Formation of Fibrin Clot (Clotting Cascade). The compounds kaolin and cacl2 have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and prostate.

Aliases & Classifications for Amaurosis Fugax

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Amaurosis Fugax, Aliases & Descriptions:

Name: Amaurosis Fugax 41
 
Transient Monocular Blindness 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

ICD1025 G45.3

Related Diseases for Amaurosis Fugax

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Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to amaurosis fugax

Symptoms for Amaurosis Fugax

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Drugs & Therapeutics for Amaurosis Fugax

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Drug clinical trials:

Search ClinicalTrials for Amaurosis Fugax

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

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Anatomical Context for Amaurosis Fugax

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MalaCards organs/tissues related to Amaurosis Fugax:

31
Eye, Endothelial, Prostate, Pituitary

Animal Models for Amaurosis Fugax or affiliated genes

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Publications for Amaurosis Fugax

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Articles related to Amaurosis Fugax:

(show top 50)    (show all 182)
idTitleAuthorsYear
1
Recurrent amaurosis fugax and hemichorea: limb-shaking TIA. (25617405)
2015
2
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. (25613128)
2015
3
Amaurosis fugax caused by neurocysticercosis. (24632665)
2014
4
Cervical rib resulting in amaurosis fugax and stroke. (24035686)
2013
5
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. (23568216)
2013
6
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. (23365782)
2013
7
Does amaurosis fugax after retrobulbar injection need any treatment? (23595404)
2013
8
Patent foramen ovale presenting with amaurosis fugax. (23472288)
2012
9
Sleep-induced amaurosis fugax. (21723066)
2011
10
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. (21302720)
2010
11
Diagnosing amaurosis fugax with emergency ultrasound. (20015107)
2010
12
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. (20934672)
2010
13
Novel mouse model of monocular amaurosis fugax. (17975099)
2007
14
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. (17456620)
2007
15
Exercise-induced vasospastic amaurosis fugax. (11831932)
2002
16
Wegener's granulomatosis presenting with amaurosis fugax. (12194103)
2002
17
Light-induced amaurosis fugax. (11336956)
2001
18
Amaurosis fugax and stenosis of the ophthalmic artery--a case report. (11668383)
2001
19
Vertigo and amaurosis fugax secondary to Takayasu's arteritis. (11459913)
2001
20
Clinical and pathophysiological features of amaurosis fugax in Japanese stroke patients. (10732827)
2000
21
The prognosis of amaurosis fugax and hemispheric transient ischemic attacks. (10396657)
1999
22
Takayasu arteritis presenting as amaurosis fugax in a man. (9517701)
1998
23
Amaurosis fugax as a symptom of carotid artery stenosis. Its relationship with ulcerated plaque. (8120072)
1994
24
Jaw claudication and amaurosis fugax secondary to atheromatous disease of the carotid arteries. (8019808)
1994
25
Amaurosis fugax: prognosis and the role of acetylsalicylic acid. (7922849)
1994
26
Brief report: treatment of vasospastic amaurosis fugax with calcium-channel blockers. (8326973)
1993
27
Amaurosis fugax in young adults. (8343483)
1993
28
Amaurosis fugax in young people. (1477040)
1992
29
Recurrent attacks of amaurosis fugax treated with calcium channel blocker. (1952830)
1991
30
Carotid endarterectomy and its alternatives in managing amaurosis fugax. (1743894)
1991
31
Amaurosis fugax in a young woman. (1972478)
1990
32
Amaurosis fugax and antiphospholipid antibodies. (1975351)
1990
33
Dynamic amaurosis fugax secondary to compression of vertebral artery. (3044227)
1988
34
Amaurosis fugax in teenagers. A migraine variant. (3344721)
1988
35
Amaurosis fugax in a patient with systemic lupus erythematosus and antiphospholipid antibodies. (3427847)
1987
36
Amaurosis fugax and thrombocythemia. (3683889)
1987
37
Postprandial transient painful amaurosis fugax. (3746361)
1986
38
Amaurosis fugax and retinal vasculitis associated with methamphetamine inhalation. (2934418)
1985
39
Reversible monocular cataract simulating amaurosis fugax. (4037603)
1985
40
Peripheral arterial occlusion and amaurosis fugax as the first manifestation of polycythemia vera. A case report. (6697006)
1984
41
Amaurosis fugax for a long duration. (6222083)
1983
42
Amaurosis fugax. (6812749)
1982
43
Demonstration of pathological circulating endothelial cells in patients with amaurosis fugax. (6946628)
1980
44
Peripapillary staphyloma and amaurosis fugax. (900730)
1977
45
Evidence of silent cerebral embolism in patients with amaurosis fugax. (915508)
1977
46
Effect of aspirin in amaurosis fugax. (4108964)
1972
47
Carotid artery surgery and intermittent monocular blindness (amaurosis fugax). (4501615)
1972
48
Effect of aspirin in amaurosis fugax. (4106235)
1971
49
The natural history of monocular amaurosis fugax. (5782087)
1969
50
Amaurosis fugax: a specific type of transient loss of vision. (13398129)
1957

Variations for Amaurosis Fugax

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Expression for genes affiliated with Amaurosis Fugax

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Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for genes affiliated with Amaurosis Fugax

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Pathways related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Metalloproteases in connective tissue degradation
9.2MMP8, SERPINE1
2
Show member pathways
9.1F5, SERPINE1
3
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.1F5, SERPINE1
4
Show member pathways
9.1F5, SERPINE1
5
Show member pathways
thioredoxin pathway36
9.0SERPINE1, MTHFR

Compounds for genes affiliated with Amaurosis Fugax

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Compounds related to Amaurosis Fugax according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1kaolin439.8APOH, F5
2cacl2439.8MMP8, F5
3coumarins439.8F5, APOH
4cardiolipin43 1210.7F5, APOH
55-methyltetrahydrofolate43 1210.7MTHFR, F5
6cystathionine439.7F5, MTHFR
7phosphatidylethanolamine43 1210.6APOH, F5
8vitamin b6439.6F5, MTHFR
9batroxobin439.5F5, SERPINE1
10ancrod439.5SERPINE1, F5
1111-dehydrothromboxane b2439.5SERPINE1, APOH
12tibolone439.5F5, SERPINE1
13cyproteroneacetate439.5F5, SERPINE1
14deoxyribonucleic acid439.4F5, APOH
15desmopressin43 59 28 1212.4SERPINE1, F5
16malondialdehyde439.4F5, APOH
178-isoprostane439.4SERPINE1, APOH
18hirudin439.4F5, SERPINE1
19p00001439.3MTHFR, SERPINE1
20dextran sulfate439.3F5, APOH
21protamine439.3F5, SERPINE1
22warfarin43 49 24 1212.2APOH, MTHFR, F5
23mycophenolate mofetil43 49 1211.2F5, SERPINE1
24vitamin b12439.2APOH, MTHFR, F5
25lactate439.2F5, MMP8, APOH
26raloxifene43 49 28 1212.2SERPINE1, F5
27folate439.2F5, MTHFR, APOH
28kininogen439.0F5, SERPINE1, APOH
29pge1439.0F5, SERPINE1, APOH
30betacarotene439.0MTHFR, APOH
31endotoxin439.0F5, SERPINE1, APOH
32prostacyclin439.0F5, SERPINE1, APOH
33metformin43 49 1210.9SERPINE1, MTHFR, F5
34methotrexate49 43 1210.9APOH, SERPINE1, MTHFR
35p002438.8F5, MTHFR, MMP8, APOH
36aspartate438.7F5, MTHFR, SERPINE1
37progesterone43 28 59 24 1212.6F5, MMP8, SERPINE1, APOH
38vegf438.6APOH, SERPINE1, MMP8, F5
39nitric oxide43 24 1210.5APOH, SERPINE1, MMP8, F5
40uric acid43 249.4APOH, SERPINE1, MTHFR, F5
41homocysteine43 249.4APOH, SERPINE1, MTHFR, F5
42cyclophosphamide43 49 1210.4APOH, SERPINE1, MTHFR, F5
43aspirin43 49 28 2411.4F5, MTHFR, SERPINE1, APOH
44creatinine438.4APOH, SERPINE1, MTHFR, F5
45heparin43 28 24 1211.4APOH, SERPINE1, MTHFR, F5
46retinoic acid43 249.4F5, MTHFR, MMP8, SERPINE1
47cholesterol43 28 24 1211.4APOH, SERPINE1, MTHFR, F5
48estrogen438.3APOH, SERPINE1, MTHFR, F5
49serine438.3SERPINE1, MMP8, MTHFR, F5
50fibrinogen438.0F5, MTHFR, MMP8, SERPINE1, APOH

GO Terms for genes affiliated with Amaurosis Fugax

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Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.1SERPINE1, APOH
2platelet alpha granule lumenGO:00310938.8F5, SERPINE1
3extracellular spaceGO:00056158.1F5, MMP8, SERPINE1, APOH

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:00519189.2SERPINE1, APOH
2positive regulation of blood coagulationGO:00301949.1SERPINE1, APOH
3platelet degranulationGO:00025769.1F5, SERPINE1
4negative regulation of blood coagulationGO:00301959.0APOH, SERPINE1
5blood circulationGO:00080159.0F5, MTHFR

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.5F5, MMP8

Products for genes affiliated with Amaurosis Fugax

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Sources for Amaurosis Fugax

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet