MCID: AMR003
MIFTS: 38

Amaurosis Fugax malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Amaurosis Fugax

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Aliases & Descriptions for Amaurosis Fugax:

Name: Amaurosis Fugax 48 27
 
Transient Monocular Blindness 48

Classifications:



External Ids:

ICD1030 G45.3

Summaries for Amaurosis Fugax

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Wikipedia:71 Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a... more...

MalaCards based summary: Amaurosis Fugax, also known as transient monocular blindness, is related to thrombophilia and transient cerebral ischemia. An important gene associated with Amaurosis Fugax is F5 (Coagulation Factor V), and among its related pathways are Complement and coagulation cascades and Matrix Metalloproteinases. Affiliated tissues include eye, endothelial and pituitary, and related mouse phenotypes are homeostasis/metabolism and integument.

Related Diseases for Amaurosis Fugax

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Diseases related to Amaurosis Fugax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia30.1F5, MTHFR
2transient cerebral ischemia11.4
3mini stroke11.1
4retinitis10.4
5collagenous colitis10.3F5, SERPINE1
6west nile fever10.2F5, SERPINE1
7retinal dystrophy, iris coloboma, and comedogenic acne syndrome10.2F5, SERPINE1
8cerebritis10.2
9artery disease10.1
10carotid artery disease10.1
11jumping frenchmen of maine10.1F5, SERPINE1
12inflammatory liposarcoma10.1MMP8, MMP9
13retinal artery occlusion10.1
14lupus erythematosus10.1
15headache10.1
16chorioretinitis10.1MMP8, MMP9
17integumentary system cancer10.0MMP8, MMP9
18intestinal variant cervical mucinous adenocarcinoma10.0MMP9, SERPINE1
19neonatal period electroclinical syndrome10.0MMP8, MMP9
20michels caskey syndrome10.0F5, MTHFR
21subcortical arteriosclerotic encephalopathy10.0F5, MTHFR
22nervous system cancer10.0MMP8, MMP9
23acute zonal occult outer retinopathy10.0F5, MTHFR
24thyroid hyalinizing trabecular adenoma10.0F5, MTHFR
25systemic lupus erythematosus10.0
26arteriovenous fistula10.0
27atherosclerosis10.0
28arteriovenous malformation10.0
29carotid stenosis10.0
30central retinal artery occlusion10.0
31carotid artery occlusion10.0
32vasculitis10.0
33neuropathy10.0
34endotheliitis10.0
35pregnancy loss, recurrent 110.0F5, MTHFR
36homocystinuria due to defect in methylation cbl g10.0F5, MTHFR
37left-right axis malformations10.0F5, MTHFR
38primary pigmented nodular adrenocortical disease10.0F5, MTHFR
39glossopharyngeal nerve neoplasm10.0MMP8, MMP9
40budd-chiari syndrome10.0F5, MTHFR
41hepatocellular adenoma10.0F5, MTHFR
42angular blepharoconjunctivitis10.0F5, MTHFR
43pseudohermaphroditism10.0F5, MTHFR
44noma10.0F5, MTHFR
45perrault syndrome10.0MMP9, SERPINE1
46neuromyelitis optica10.0MTHFR, SERPINE1
47joint disorders9.9F5, MTHFR
48lip carcinoma in situ9.9F5, MTHFR
49hypertensive heart disease9.9MTHFR, SERPINE1
50spastic paraplegia 3a9.9F5, MTHFR

Graphical network of the top 20 diseases related to Amaurosis Fugax:



Diseases related to amaurosis fugax

Symptoms & Phenotypes for Amaurosis Fugax

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MGI Mouse Phenotypes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.3F5, MMP8, MMP9, MTHFR, SERPINE1
2MP:00107718.1F5, MMP9, MTHFR, SERPINE1

Drugs & Therapeutics for Amaurosis Fugax

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Drugs for Amaurosis Fugax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mannitolapproved, investigationalPhase 226869-65-8453, 6251
Synonyms:
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
(L)-Mannitol
1,2,3,4,5,6-Hexanehexol
123897-58-5
133-43-7
15719_ALDRICH
15719_RIEDEL
33440_RIEDEL
33440_SIGMA
36413-61-3
4-01-00-02841 (Beilstein Handbook Reference)
5149-40-6
63559_FLUKA
63559_SIGMA
63560_FLUKA
63565_FLUKA
63565_SIGMA
69-65-8
75398-80-0
85085-15-0
87-78-5
AB1002081
AC-12776
AC1L1M49
AC1Q28E5
AI3-19511
AR-1J3861
Ambap69-65-8
BRN 1721898
C00392
C6H14O6
CCRIS 369
CHEBI:16899
CHEMBL689
CID6251
Cordycepate
Cordycepic acid
D-(-)-Mannitol
D-Mannitol
D-Mannitol (JP15)
D-mannite
D-mannitol
D00062
D008353
DL-Mannitol
Diosmol
ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D
EINECS 200-711-8
EINECS 201-770-2
Fraxinine
HSDB 714
Hexahydroxyhexane
Hexanhexol
Invenex
Isotol
LS-1588
LS-89250
M0044
M1902_SIGMA
M4125_SIAL
M8429_SIAL
M9546_SIAL
M9647_SIAL
MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
 
MANNITOL 25%
MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
MLS001335977
MLS001335978
MTL
Manicol
Manitol
Maniton S
Maniton-S
Manna Sugar
Manna sugar
Mannazucker
Mannidex
Mannidex 16700
Mannigen
Mannistol
Mannit
Mannit p
Mannite
Mannitol
Mannitol (USP)
Mannitol (VAN)
Mannitol 10%
Mannitol 10% In Plastic Container
Mannitol 15%
Mannitol 15% In Plastic Container
Mannitol 20%
Mannitol 20% In Plastic Container
Mannitol 5%
Mannitol 5% In Plastic Container
Mannitol [USAN]
Mannitolum
Mannogem 2080
Marine Crystal
Marine crystal
MolPort-003-927-039
Mushroom sugar
NCGC00164246-01
NCI-C50362
NSC 407017
NSC 9256
OSMITROL 10% IN WATER IN PLASTIC CONTAINER
OSMITROL 15% IN WATER IN PLASTIC CONTAINER
OSMITROL 20% IN WATER IN PLASTIC CONTAINER
OSMITROL 5% IN WATER IN PLASTIC CONTAINER
Osmitrol
Osmitrol (TN)
Osmitrol 10% In Water
Osmitrol 15% In Water
Osmitrol 20% In Water
Osmitrol 5% In Water
Osmofundin
Osmosal
Resectisol
Resectisol In Plastic Container
SDM No. 35
SMR000857324
SORBITOL-MANNITOL IN PLASTIC CONTAINER
Sorbitol-Mannitol
TL806434
UNII-3OWL53L36A
ZINC02041302
bmse000099
cpd without stereochemical designation
e 421
e-421
e421
manita
mannitol
2Natriuretic AgentsPhase 21645
3diureticsPhase 21372

Interventional clinical trials:

idNameStatusNCT IDPhase
1Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)RecruitingNCT01645306Phase 2
2Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid EndarterectomyCompletedNCT01445613
3Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT)CompletedNCT00402740

Search NIH Clinical Center for Amaurosis Fugax

Genetic Tests for Amaurosis Fugax

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Genetic tests related to Amaurosis Fugax:

id Genetic test Affiliating Genes
1 Amaurosis Fugax27

Anatomical Context for Amaurosis Fugax

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MalaCards organs/tissues related to Amaurosis Fugax:

36
Eye, Endothelial, Pituitary, Prostate

Publications for Amaurosis Fugax

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Articles related to Amaurosis Fugax:

(show top 50)    (show all 192)
idTitleAuthorsYear
1
Amaurosis fugax - delay between symptoms and surgery by specialty. (27895459)
2016
2
Amaurosis fugax associated with congenital vascular defect. (27445507)
2016
3
Amaurosis fugax: risk factors and prevalence of significant carotid stenosis. (27826182)
2016
4
A fatal case of primary cardiac chondrosarcoma presenting with amaurosis fugax. (26438683)
2015
5
Increased intraocular pressure after vitreoretinal surgery as a cause of ipsilateral amaurosis fugax upon rising to a standing position. (25613128)
2015
6
Amaurosis Fugax, Anterior Ischemic Optic Neuropathy and Cilioretinal Artery Occlusion Secondary to Giant Cell Arteritis. (26234004)
2015
7
Headache and amaurosis fugax in an obese woman. (26627820)
2015
8
Recurrent amaurosis fugax and hemichorea: limb-shaking TIA. (25617405)
2015
9
IMAGES IN CLINICAL MEDICINE. Amaurosis Fugax Caused by a Branch Retinal Artery Embolus. (26605943)
2015
10
Amaurosis Fugax Captured During Fluorescein Angiography. (26049618)
2015
11
Vasospastic Amaurosis Fugax Diagnosed by Cerebral Angiography. (26283520)
2015
12
Amaurosis fugax caused by neurocysticercosis. (24632665)
2014
13
A traveling "spot sign" in recurrent amaurosis fugax and central retinal artery occlusion. (24957310)
2014
14
Young patient with headache and amaurosis fugax. (24193794)
2014
15
AMAUROSIS FUGAX IN OCULAR VASCULAR OCCLUSIVE DISORDERS: Prevalence and Pathogeneses. (23632956)
2014
16
ECG of the Month: Amaurosis Fugax in a 45-Year-Old Woman. (25075509)
2014
17
Light-induced amaurosis fugax due to severe distal internal carotid artery stenosis: in view of managing ocular ischemic syndrome. (23568216)
2013
18
Does amaurosis fugax after retrobulbar injection need any treatment? (23595404)
2013
19
Cervical rib resulting in amaurosis fugax and stroke. (24035686)
2013
20
Detection of unstable carotid plaque by tissue Doppler imaging and contrast-enhanced ultrasound in a patient with recurrent amaurosis fugax. (23365782)
2013
21
Serial carotid MRI identifies rupture of a vulnerable plaque resulting in amaurosis fugax. (23509049)
2013
22
Takayasu retinopathy presenting as amaurosis fugax in a young patient. (25390509)
2013
23
Patent foramen ovale presenting with amaurosis fugax. (23472288)
2012
24
An unusual case of amaurosis fugax due to papillary fibroelastoma of cor triatriatum. (21831902)
2012
25
Recurrent amaurosis fugax in a patient after stanford type a dissection depending on blood pressure and haemoglobin level. (23198268)
2012
26
Sleep-induced amaurosis fugax. (21723066)
2011
27
Don't forget amaurosis fugax. (21690157)
2011
28
Amaurosis fugax is in the first place, during attack, medical emergency for ophthalmologist's practice. (21302720)
2010
29
Diagnosing amaurosis fugax with emergency ultrasound. (20015107)
2010
30
Retinal artery embolization from a calcified bicuspid aortic valve causing amaurosis fugax. (20934672)
2010
31
Monocular amaurosis fugax as the heralding symptom of vasovagal syncope. (20434591)
2010
32
From amaurosis fugax to asymptomatic bithalamic infarct. (19252800)
2009
33
Amaurosis fugax caused by hereditary thrombophilia due to mutation of gene. (19507653)
2009
34
Time to carotid endarterectomy. Don't forget amaurosis fugax. (19564188)
2009
35
Optic neuritis presenting with amaurosis fugax. (19727900)
2009
36
Common carotid artery stenosis and amaurosis fugax. (18190813)
2008
37
Amaurosis fugax secondary to imaging methods of MRI scan. (17178375)
2007
38
Amaurosis fugax caused by retinal artery vasospasm. Case illustration. (17542546)
2007
39
Novel mouse model of monocular amaurosis fugax. (17975099)
2007
40
Amaurosis fugax caused by heritable thrombophilia-hypofibrinolysis in cases without carotid atherosclerosis: thromboprophylaxis prevents subsequent transient monocular partial blindness. (17456620)
2007
41
Recurrent anterior chamber hemorrhage from an intraocular lens simulating amaurosis fugax. (17662452)
2007
42
Endoscopic epinephrine injection induced amaurosis fugax. (16911707)
2006
43
Do complaints of amaurosis fugax and blurred vision after transcatheter device closure of atrial septal defect indicate microemboli to retinal vessels? (16137504)
2005
44
Do complaints of amaurosis fugax and blurred vision after transcatheter device closure of atrial septal defect indicate microemboli to retinal vessels? (15788050)
2005
45
Amaurosis fugax: associations with heritable thrombophilia. (16015408)
2005
46
Ventricular tachycardia and amaurosis fugax following inadvertent left ventricular pacing. (15771935)
2005
47
Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients. (16376194)
2005
48
A case of frequently recurring amaurosis fugax with atherothrombotic ophthalmic artery occlusion. (14718711)
2004
49
Vasospastic amaurosis fugax. (12531936)
2003
50
Diabetic retinopathy with repeated amaurosis fugax caused by orthostatic hypotension. (14597053)
2003

Variations for Amaurosis Fugax

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Expression for genes affiliated with Amaurosis Fugax

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Search GEO for disease gene expression data for Amaurosis Fugax.

Pathways for genes affiliated with Amaurosis Fugax

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GO Terms for genes affiliated with Amaurosis Fugax

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Cellular components related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.5F5, SERPINE1
2extracellular regionGO:00055769.1F5, MMP8, MMP9, SERPINE1
3extracellular spaceGO:00056158.8F5, MMP8, MMP9, SERPINE1

Biological processes related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.9MMP8, MMP9
2endodermal cell differentiationGO:00359879.9MMP8, MMP9
3extracellular matrix disassemblyGO:00226179.9MMP8, MMP9
4blood circulationGO:00080159.8F5, MTHFR
5platelet degranulationGO:00025769.5F5, SERPINE1

Molecular functions related to Amaurosis Fugax according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.9MMP8, MMP9
2serine-type endopeptidase activityGO:00042528.9F5, MMP8, MMP9

Sources for Amaurosis Fugax

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet