MCID: AMB002
MIFTS: 46

Amblyopia malady

Summaries for Amblyopia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Amblyopia is an eye disorder characterized by an impaired vision in an eye that otherwise appears... more...

MalaCards: Amblyopia, also known as amblyopia, unspecified, is related to suppression amblyopia and hyperopia. An important gene associated with Amblyopia is SIX3 (SIX homeobox 3), and among its related pathways are Hypothetical Network for Drug Addiction and Glutamic acid signaling. The compounds l-glutamic acid and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and retina, and related mouse phenotypes are behavior/neurological and vision/eye.

Aliases & Classifications for Amblyopia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM
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Aliases & Descriptions:

amblyopia 8 10 61
amblyopia, unspecified 8
unspecified amblyopia 8


External Ids:

Disease Ontology8 DOID:10376
MeSH35 D000550
ICD9CM27 368.00

Related Diseases for Amblyopia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amblyopia:



Diseases related to amblyopia

Clinical Features for Amblyopia

Drugs & Therapeutics for Amblyopia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Amblyopia

Drug clinical trials:

Search ClinicalTrials for Amblyopia

Search NIH Clinical Center for Amblyopia

Search CenterWatch for Amblyopia

Genetic Tests for Amblyopia

Anatomical Context for Amblyopia

Sources:
33MalaCards
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MalaCards organs/tissues related to Amblyopia:

33
Brain, Cortex, Retina, Small intestine, Fetal brain, Temporal lobe, Occipital lobe, Pituitary

Animal Models for Amblyopia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Amblyopia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.0ROBO3, SIRPA, GPR17, GRM6, GRM1, GRIN1
2MP:00053918.8FBXO7, LDLR, SIX3, AXL, DPT, GRM6
3MP:00036318.5PHOX2A, PRSS56, GRIN1, GRM1, GRM6, AXL

Publications for Amblyopia

Sources:
51PubMed
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Articles related to Amblyopia:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Amblyopia Treatment Strategies and New Drug Therapies. (24410693)
2014
2
Retinal nerve fibre layer thickness and macular thickness in patients with esotropic amblyopia. (23421941)
2013
3
Part-time vs. full-time occlusion for amblyopia: evidence for part-time patching. (24260802)
2013
4
The effects of spatial offset, temporal offset and image speed on sensitivity to global motion in human amblyopia. (23628451)
2013
5
Amblyopia secondary to iris cyst. (24365400)
2013
6
The outcome of combining home based and clinic based amblyopia therapy among preschool children. (23749015)
2013
7
Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia. (24195034)
2013
8
"Binocular Vision Amblyopia"; Photoscreening Devices, Accommodation (Convergence) following Myopic PRK and Atropine for Amblyopia...or Epigenetic Myopia. (23521037)
2013
9
A comparison between the amblyopic eye and normal fellow eye ocular architecture in children with hyperopic anisometropic amblyopia. (23273939)
2013
10
Effectiveness of screening for amblyopia and other eye disorders in a prospective birth cohort study. (24009090)
2013
11
Grey and white matter changes in children with monocular amblyopia: voxel-based morphometry and diffusion tensor imaging study. (23343654)
2013
12
Clinical translation of recommendations from randomized clinical trials on patching regimen for amblyopia. (23395531)
2013
13
"Binocular Vision "Dysfunction"; A Primary Factor for Amblyopia; Goodbye Leonard, Thanks; AAPOS Boston; It's OK; Paternal Epigenetics; Myopia. (23822911)
2013
14
Optical treatment of strabismic and combined strabismic-anisometropic amblyopia. (21959371)
2012
15
A prospective pilot study of treatment outcomes for amblyopia associated with myopic anisometropia. (22232365)
2012
16
Screening for amblyopia risk factors in pre-verbal children using the Plusoptix photoscreener: a cross-sectional population-based study. (21515564)
2012
17
The effect of anisometropic amblyopia on retrobulbar blood flow parameters. Anisometropic amblyopia and retrobulbar blood flow. (22552580)
2012
18
Occlusion dose monitor available for electronic recording of compliance in patch wearing for amblyopia. (22390334)
2012
19
Pharmacological enhancement of treatment for amblyopia. (22536029)
2012
20
Temporal synchrony deficits in amblyopia. (23139268)
2012
21
Can human amblyopia be treated in adulthood? (21870913)
2011
22
The perceptual consequences of interocular suppression in amblyopia. (22025565)
2011
23
High prevalence of amblyopia risk factors in preverbal children with nasolacrimal duct obstruction. (21907117)
2011
24
Can perceptual learning be used to treat amblyopia beyond the critical period of visual development? (21981034)
2011
25
Simultaneous pattern visual evoked potential and pattern electroretinogram in strabismic and anisometropic amblyopia. (22946015)
2011
26
Macular and peripapillary retinal nerve fibre layer thickness in adults with amblyopia. (21995986)
2011
27
Amblyopia and real-world visuomotor tasks. (21870915)
2011
28
Unilateral amblyopia: Optical coherence tomography findings. (23960955)
2011
29
The role of suppression in amblyopia. (21447685)
2011
30
Impaired visual decision-making in individuals with amblyopia. (22147222)
2011
31
Refractory reverse amblyopia with atropine penalization. (21120053)
2010
32
Study of the wavefront aberrations in children with amblyopia. (20819602)
2010
33
An audit of the outcome of amblyopia treatment: a retrospective analysis of 322 children. (19955200)
2010
34
Bilateral uneven cataracts in children: amblyopia management by sequential intraocular lens implantation. (19247388)
2009
35
Amblyopia. (21726480)
2009
36
Fixation preference and visual acuity testing in a population-based cohort of preschool children with amblyopia risk factors. (18962921)
2009
37
Pupillography of automated swinging flashlight test in amblyopia. (19668431)
2008
38
Interventions for unilateral refractive amblyopia. (18843683)
2008
39
Relationship between anisometropia, patient age, and the development of amblyopia. (16815261)
2006
40
Screening for amblyopia in preverbal children: improved grading criteria for hyperopia. (11581024)
2001
41
Is it mandatory to treat amblyopia prior to surgery in esotropia? (11167282)
2001
42
Neuronal correlates of amblyopia in the visual cortex of macaque monkeys with experimental strabismus and anisometropia, by L. Kiorpes, D. Kiper, L. O'Keefe, J. Cavanaugh, and A. Movshon. J neuroscience 18:6411-24, 1998. (11033044)
2000
43
Amblyopia and the monofixation syndrome. (550915)
1979
44
Hereditary quadriplegia and amblyopia in the Irish Setter. (4803922)
1973
45
Relationship between degree of anisometropia and depth of amblyopia. (5929144)
1966
46
A follow-up study of suppression amblyopia in children previously subjected to hypnotherapy. (13914230)
1961
47
Symposium: the nonsurgical treatment of strabismus. The management of suppression amblyopia. (13712369)
1961
48
Relief of amblyopia in pituitary apoplexy by prompt surgical intervention. (13271127)
1955
49
Cortical potential changes in suppression amblyopia. (14894604)
1952
50
A case of color-blindness in a railroad employee due to tobacco amblyopia, failing to be recognized by any of the wool tests but immediately detected by lamp. (16691963)
1902

Genetic Variations for Amblyopia

Expression for genes affiliated with Amblyopia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amblyopia

Search GEO for disease gene expression data for Amblyopia.

Pathways for genes affiliated with Amblyopia

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems
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Pathways related to Amblyopia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1GRM1, GRIN1
210.0GRM6, GRM1, GRIN1
3
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10.0GRM6, GRM1, GRIN1

Compounds for genes affiliated with Amblyopia

Sources:
29IUPHAR, 11DrugBank, 24HMDB, 45Novoseek
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Compounds related to Amblyopia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1l-glutamic acid29 11 2412.1GRM6, GRM1, GRIN1
2alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4510.0GRIN1, GRM1
3kainate45 2911.0GRM6, GRM1, GRIN1
4nmda45 2910.9GRIN1, GRM1, GRM6, LDLR
5glutamate459.6LDLR, GRM6, GRM1, GRIN1, CSAD
6nitric oxide45 11 2410.9CSAD, GRIN1, GRM1, SIRPA, CPD

GO Terms for genes affiliated with Amblyopia

Sources:
16Gene Ontology
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Cellular components related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.4LDLR, GPR17, AXL, GRM6, GRM1, GRIN1

Biological processes related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of respiratory gaseous exchangeGO:04357610.1GRIN1, PHOX2A

Molecular functions related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate receptor activityGO:00806610.2GRM6, GRM1

Products for genes affiliated with Amblyopia

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  • Lysates
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Sources for Amblyopia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet