MCID: AMB002
MIFTS: 46

Amblyopia malady

Summaries for Amblyopia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Amblyopia (also called \"lazy eye\") is an eye disorder characterized by an impaired (reduced) vision in... more...

MalaCards: Amblyopia, also known as amblyopia, unspecified, is related to suppression amblyopia and refractive error. An important gene associated with Amblyopia is SIX3 (SIX homeobox 3), and among its related pathways are Hypothetical Network for Drug Addiction and Glutamic acid signaling. The compounds l-glutamic acid and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex, and related mouse phenotypes are behavior/neurological and vision/eye.

Aliases & Classifications for Amblyopia

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

amblyopia 8 10 60
amblyopia, unspecified 8
unspecified amblyopia 8


External Ids:

Disease Ontology8 DOID:10376
MeSH34 D000550
ICD9CM27 368.00

Related Diseases for Amblyopia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amblyopia:



Diseases related to amblyopia

Clinical Features for Amblyopia

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Drugs & Therapeutics for Amblyopia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Amblyopia

Search CenterWatch for Amblyopia

Genetic Tests for Amblyopia

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Anatomical Context for Amblyopia

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32MalaCards
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MalaCards organs/tissues related to Amblyopia:

32
Eye, Testes, Cortex, Brain, Retina, Occipital lobe, Pituitary

Animal Models for Amblyopia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Amblyopia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.0GRIN1, GRM1, GRM6, GPR17, SIRPA, ROBO3
2MP:00053918.8LDLR, FBXO7, PRSS56, GRIN1, GRM1, GRM6
3MP:00036318.5PHOX2A, PRSS56, GRIN1, GRM1, GRM6, AXL

Publications for Amblyopia

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50PubMed
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Articles related to Amblyopia:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Combined optical and atropine treatment of children with residual amblyopia after atropine penalization. (23429575)
2013
2
L-dopa methyl ester attenuates amblyopia-induced neuronal injury in visual cortex of amblyopic cat. (23774688)
2013
3
Global processing of orientation in amblyopia. (23462430)
2013
4
Transcranial direct current stimulation enhances recovery of stereopsis in adults with amblyopia. (23857313)
2013
5
Impact of Cylinder Axis on the Treatment for Astigmatic Amblyopia. (24384526)
2013
6
Repetitive visual stimulation enhances recovery from severe amblyopia. (23685763)
2013
7
Association between accommodative amplitudes and amblyopia. (23713938)
2013
8
Two-year follow-up of a randomized trial of spectacles alone or combined with Bangerter filters for treating anisometropic amblyopia. (21883985)
2013
9
Risk Factors for Amblyopia in the Vision in Preschoolers Study. (24140117)
2013
10
Echelette optical low-pass filter as a Bangerter filter for diagnosis and treatment of amblyopia and diplopia. (24323161)
2013
11
How the visual cortex handles stimulus noise: insights from amblyopia. (23818947)
2013
12
Frequent Evaluation To Improve Compliance In Patients Treated With Occlusion For Amblyopia: A Randomized controlled Trial. (22989342)
2012
13
A limited role for suppression in the central field of individuals with strabismic amblyopia. (22649494)
2012
14
A novel apparatus for interocular interaction evaluation in children with and without anisometropic amblyopia. (22681574)
2012
15
Tobacco-alcohol amblyopia: Nonexistent entity. (23766586)
2012
16
Compliance to patching in the treatment of amblyopia. (23961010)
2012
17
Low-level laser therapy improves visual acuity in adolescent and adult patients with amblyopia. (22235969)
2012
18
Unilateral optic nerve sheath meningocele presented with amblyopia. (21800781)
2011
19
The pattern of learned visual improvements in adult amblyopia. (21810976)
2011
20
Acupuncture for amblyopia: study design considerations. (21911685)
2011
21
Amblyopia and strabismus in Iranian schoolchildren, Mashhad. (22107119)
2011
22
Restoration of binocular vision in amblyopia. (21870914)
2011
23
LASIK correction of vision in adults with unilateral amblyopia. (20415286)
2011
24
Prevalence of amblyopia and strabismus in young singaporean chinese children. (20207979)
2010
25
Anisometropic amblyopia: axial length versus corneal curvature in children with severe refractive imbalance. (21035064)
2010
26
The global shape detection deficit in strabismic amblyopia: Contribution of local orientation and position. (20510268)
2010
27
Effect and sustainability of part-time occlusion therapy for patients with anisometropic amblyopia aged > or =8 years. (20530177)
2010
28
Scale-dependent loss of global form perception in strabismic amblyopia. (21047757)
2010
29
A randomized trial comparing Bangerter filters and patching for the treatment of moderate amblyopia in children. (20163869)
2010
30
Evaluating the burden of amblyopia treatment from the parent and child's perspective. (21035063)
2010
31
The base-to-base induced-tropia prism test for detection of amblyopia: a pilot study. (21168071)
2010
32
Amblyopia after unilateral infantile cataract extraction after six weeks of age. (20027402)
2009
33
Bilateral abnormalities of optic nerve size and eye shape in unilateral amblyopia. (19573859)
2009
34
Amblyopia treatment: 1998 versus 2004. (19213272)
2009
35
Treatment of severe amblyopia with atropine: Results from 2 randomized clinical trials. (20640038)
2009
36
Electronic monitoring of occlusion treatment for amblyopia in patients aged 7 to 16 years. (19415317)
2009
37
Thickness of the retinal nerve fiber layer in amblyopia. (19932805)
2009
38
Different corrections of hypermetropic errors in the successful treatment of hypermetropic amblyopia in children 3 to 7 years of age. (18930448)
2009
39
Learning to identify near-threshold luminance-defined and contrast-defined letters in observers with amblyopia. (18824189)
2008
40
Retinal area and optic disc rim area in amblyopic, fellow, and normal hyperopic eyes: a hypothesis for decreased acuity in amblyopia. (18801577)
2008
41
Long-term visual function and relative amblyopia in posterior persistent hyperplastic primary vitreous (PHPV). (16760119)
2006
42
The relationship between anisometropia, patient age, and the development of amblyopia. (17057809)
2005
43
Retinal nerve fiber analysis in subjects with hyperopia and anisometropic amblyopia. (15828869)
2005
44
Isoametropic amblyopia due to high hyperopia in children. (15314589)
2004
45
Visual acuity and color vision deficiency in amblyopia. (10744210)
2000
46
Untreated essential infantile esotropia: factors affecting the development of amblyopia. (9683932)
1998
47
Effectiveness of occlusion therapy in ametropic amblyopia. (9924395)
1998
48
The association of strabismus, amblyopia, and refractive errors in spasmus nutans. (9022113)
1997
49
Anisometropia and amblyopia in straight eyes. (4789112)
1973
50
Exanoptic and suppression amblyopia. (14037734)
1962

Genetic Variations for Amblyopia

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Expression for genes affiliated with Amblyopia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amblyopia

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Pathways for genes affiliated with Amblyopia

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37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
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Pathways related to Amblyopia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1GRM1, GRIN1
210.0GRM6, GRM1, GRIN1
3
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10.0GRM6, GRM1, GRIN1

Compounds for genes affiliated with Amblyopia

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28IUPHAR, 11DrugBank, 24HMDB, 44Novoseek
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Compounds related to Amblyopia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1l-glutamic acid28 11 2412.1GRM6, GRM1, GRIN1
2alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4410.0GRIN1, GRM1
3kainate44 2811.0GRM6, GRM1, GRIN1
4nmda44 2810.9GRIN1, GRM1, GRM6, LDLR
5glutamate449.6LDLR, GRM6, GRM1, GRIN1, CSAD
6nitric oxide44 11 2410.9CSAD, GRIN1, GRM1, SIRPA, CPD

GO Terms for genes affiliated with Amblyopia

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16Gene Ontology
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Cellular components related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.4LDLR, GPR17, AXL, GRM6, GRM1, GRIN1

Biological processes related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of respiratory gaseous exchangeGO:04357610.1GRIN1, PHOX2A

Molecular functions related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate receptor activityGO:00806610.2GRM6, GRM1

Products for genes affiliated with Amblyopia

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Sources for Amblyopia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet