MCID: AMB002
MIFTS: 46

Amblyopia malady

Summaries for Amblyopia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Amblyopia (also called \"lazy eye\") is an eye disorder characterized by an impaired (reduced) vision in... more...

MalaCards: Amblyopia, also known as amblyopia, unspecified, is related to suppression amblyopia and refractive error. An important gene associated with Amblyopia is SIX3 (SIX homeobox 3), and among its related pathways are Hypothetical Network for Drug Addiction and Glutamic acid signaling. The compounds l-glutamic acid and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex, and related mouse phenotypes are behavior/neurological and vision/eye.

Aliases & Classifications for Amblyopia

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

amblyopia 8 10 60
amblyopia, unspecified 8
unspecified amblyopia 8


External Ids:

Disease Ontology8 DOID:10376
MeSH34 D000550
ICD9CM27 368.00

Related Diseases for Amblyopia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amblyopia:



Diseases related to amblyopia

Clinical Features for Amblyopia

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Drugs & Therapeutics for Amblyopia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Amblyopia

Drug clinical trials:

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Search NIH Clinical Center for Amblyopia

Search CenterWatch for Amblyopia

Genetic Tests for Amblyopia

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Anatomical Context for Amblyopia

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32MalaCards
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MalaCards organs/tissues related to Amblyopia:

32
Eye, Testes, Cortex, Brain, Retina, Occipital lobe, Pituitary

Animal Models for Amblyopia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Amblyopia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.0ROBO3, SIRPA, GPR17, GRM6, GRM1, GRIN1
2MP:00053918.8FBXO7, LDLR, SIX3, AXL, DPT, GRM6
3MP:00036318.5PHOX2A, PRSS56, GRIN1, GRM1, GRM6, AXL

Publications for Amblyopia

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50PubMed
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Articles related to Amblyopia:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Performance of Four New Photoscreeners on Pediatric Patients With High Risk Amblyopia. (24369683)
2014
2
Outcome of conventional treatment for adult amblyopia. (24158452)
2014
3
Functional Amblyopia and Deficient Binocular Vision as Initial Clinical Features in Duane's Syndrome. (24063511)
2013
4
Effects of atropine on the accommodative system: parameters to consider in its use for penalization treatment of amblyopia. (23521035)
2013
5
Visual evoked potential importance in the complex mechanism of amblyopia. (23417145)
2013
6
Delayed resolution of eyelid swelling in preseptal cellulitis in a child: beware of causing occlusion amblyopia. (23476010)
2013
7
Factors predicting recurrence in successfully treated cases of anisometropic amblyopia. (24343594)
2013
8
Amblyopia: out of the dark, into the light. (23473559)
2013
9
The effects of blur and eccentric viewing on adult acuity for pediatric tests: implications for amblyopia detection. (24071956)
2013
10
Incidence of strabismus and amblyopia in preverbal children previously diagnosed with pseudoesotropia. (24141760)
2013
11
Amblyopia risk factors in infants with congenital nasolacrimal duct obstruction. (23851753)
2013
12
Advances in amblyopia: what have we learned from PEDIG trials? (23382445)
2013
13
Structural and functional comparison of the persistent and resolved amblyopia. (24343574)
2013
14
Altered functional connectivity of the primary visual cortex in subjects with amblyopia. (23844297)
2013
15
Prevalence of amblyopia and refractive errors in an unscreened population of children. (23069721)
2012
16
The effect of sensory uncertainty due to amblyopia (lazy eye) on the planning and execution of visually-guided 3D reaching movements. (22363549)
2012
17
Learning to identify near-acuity letters, either with or without flankers, results in improved letter size and spacing limits in adults with amblyopia. (22558234)
2012
18
Unilateral myelinated nerve fibers associated with ipsilateral myopia and amblyopia. (24132692)
2012
19
A retrospective study of treatment efficacy of 65 children with ametroic amblyopia. (22678871)
2012
20
Abruptly developed large esotropia after full time occlusion therapy in anisometropic amblyopia. (23166882)
2012
21
General health-related quality of life in preschool children with strabismus or amblyopia. (20884059)
2011
22
Sociocultural and psychological determinants in migrants for noncompliance with occlusion therapy for amblyopia. (21399941)
2011
23
Bilateral hypermetropia, myelinated retinal nerve fibers, and amblyopia. (21572738)
2011
24
Adjunctive effect of acupuncture to refractive correction on anisometropic amblyopia: one-year results of a randomized crossover trial. (21459451)
2011
25
Training in contrast detection improves motion perception of sinewave gratings in amblyopia. (21693615)
2011
26
Photorefractive keratectomy in treatment of refractive amblyopia in the adult population. (22108111)
2011
27
Visual acuity after laser in situ keratomileusis to correct high astigmatism in adults with meridional amblyopia. (21851919)
2011
28
Charlie Brown, amblyopia, and me: A (not so short) personal history of the past forty years of diagnosing and treating amblyopia. (21061887)
2010
29
Multifocal visual evoked potentials in amblyopia due to anisometropia. (20714361)
2010
30
Randomized controlled trial of patching vs acupuncture for anisometropic amblyopia in children aged 7 to 12 years. (21149771)
2010
31
Comparing a traditional single optotype visual acuity test with a computer-based visual acuity test for childhood amblyopia vision screening: a pilot study. (20648081)
2010
32
Independent and reciprocal accommodation in anisometropic amblyopia. (20863728)
2010
33
An evaluation of the Amblyopia and Strabismus Questionnaire using Rasch analysis. (20053981)
2010
34
Anterior chamber phakic intraocular lens implantation in children to treat severe anisometropic myopia and amblyopia: 3-year clinical results. (20692559)
2010
35
The clinical profile of amblyopia in children younger than 3 years of age. (21168072)
2010
36
Cortical mechanisms of normal and abnormal processing in the visual system, Part 1. Spatial vision, amblyopia, hyperacuity, modal assumptions: a review. (19564674)
2009
37
Experiences with the elimination of amblyopia and the restoration of binocular vision in squinters, part III. (20001514)
2009
38
Pharmacological plus optical penalization treatment for amblyopia: results of a randomized trial. (19139333)
2009
39
The prevalence of anisometropia aniso-astigmatism and amblyopia in neurofibromatosis type 1. (19396797)
2009
40
Evaluation of central, steady, maintained fixation grading for predicting inter-eye visual acuity difference to diagnose and treat amblyopia in strabismic patients. (19574695)
2009
41
Changes in visual function following optical treatment of astigmatism-related amblyopia. (18261760)
2008
42
Restoration of underdeveloped cortical functions: evidence from treatment of adult amblyopia. (18997316)
2008
43
The age-dependent effect of anisometropia magnitude on anisometropic amblyopia severity. (18155938)
2008
44
The clinical effectiveness and cost-effectiveness of screening programmes for amblyopia and strabismus in children up to the age of 4-5 years: a systematic review and economic evaluation. (18513466)
2008
45
Relationship between anisometropia, amblyopia, and binocularity. (10524781)
1999
46
Does experimentally-induced amblyopia cause hyperopia in monkeys? (7610589)
1995
47
Eight cases of congenital achromatopsia with amblyopia in two pedigrees from Northern Sweden. (316638)
1979
48
Aniseikonia due to strabismic amblyopia. (5057867)
1972
49
The practical management of suppression amblyopia. (5089862)
1971
50
Anisometropia and amblyopia in Duane's syndrome. (5441354)
1970

Genetic Variations for Amblyopia

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Expression for genes affiliated with Amblyopia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amblyopia

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Pathways for genes affiliated with Amblyopia

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37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
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Pathways related to Amblyopia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1GRM1, GRIN1
210.0GRM6, GRM1, GRIN1
3
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10.0GRM6, GRM1, GRIN1

Compounds for genes affiliated with Amblyopia

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28IUPHAR, 11DrugBank, 24HMDB, 44Novoseek
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Compounds related to Amblyopia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1l-glutamic acid28 11 2412.1GRIN1, GRM1, GRM6
2alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid4410.0GRM1, GRIN1
3kainate44 2811.0GRIN1, GRM1, GRM6
4nmda44 2810.9LDLR, GRM6, GRM1, GRIN1
5glutamate449.6GRM6, GRM1, GRIN1, CSAD, LDLR
6nitric oxide44 11 2410.9CSAD, GRIN1, GRM1, SIRPA, CPD

GO Terms for genes affiliated with Amblyopia

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16Gene Ontology
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Cellular components related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.4LDLR, GPR17, AXL, GRM6, GRM1, GRIN1

Biological processes related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of respiratory gaseous exchangeGO:04357610.1GRIN1, PHOX2A

Molecular functions related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate receptor activityGO:00806610.2GRM6, GRM1

Products for genes affiliated with Amblyopia

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Sources for Amblyopia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet