Aliases & Classifications for Amblyopia

Aliases & Descriptions for Amblyopia:

Name: Amblyopia 12 29 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10376
ICD10 33 H53.00
ICD9CM 35 368.00
MeSH 42 D000550
NCIt 47 C118764
UMLS 69 C0002418

Summaries for Amblyopia

MedlinePlus : 41 amblyopia, or "lazy eye," is the most common cause of visual impairment in children. it happens when an eye fails to work properly with the brain. the eye may look normal, but the brain favors the other eye. in some cases, it can affect both eyes. causes include strabismus - a disorder in which the two eyes don't line up in the same direction refractive error in an eye - when one eye cannot focus as well as the other, because of a problem with its shape. this includes nearsightedness, farsightedness, and astigmatism. cataract - a clouding in the lens of the eye it can be hard to diagnose amblyopia. it is often found during a routine vision exam. treatment for amblyopia forces the child to use the eye with weaker vision. there are two common ways to do this. one is to have the child wear a patch over the good eye for several hours each day, over a number of weeks to months. the other is with eye drops that temporarily blur vision. each day, the child gets a drop of a drug called atropine in the stronger eye. it is also sometimes necessary to treat the underlying cause. this could include glasses or surgery. nih: national eye institute

MalaCards based summary : Amblyopia is related to disuse amblyopia and ametropic amblyopia, and has symptoms including other specified visual disturbances, photophobia and blurred vision. An important gene associated with Amblyopia is GRIN1 (Glutamate Ionotropic Receptor NMDA Type Subunit 1). The drugs Atropine and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are growth/size/body region and nervous system

Wikipedia : 71 Amblyopia, also called lazy eye, is a disorder of sight due to the eye and brain not working well... more...

Related Diseases for Amblyopia

Diseases related to Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
id Related Disease Score Top Affiliating Genes
1 disuse amblyopia 32.2 CYCS DPT GRIN1 HNMT OPTN SIRPA
2 ametropic amblyopia 12.2
3 suppression amblyopia 12.1
4 esotropia 11.2
5 strabismus 11.1
6 astigmatism 11.0
7 duane retraction syndrome 2 10.8
8 microphthalmia, isolated 6 10.8
9 cerulean cataract 10.8
10 isolated duane retraction syndrome 10.7
11 cataract 41 10.7
12 mental retardation, anterior maxillary protrusion, and strabismus 10.7
13 duane retraction syndrome 1 10.7
14 aniridia 10.7
15 fibrosis of extraocular muscles, congenital, 1 10.7
16 duane retraction syndrome 10.7
17 albinism 10.7
18 cognitive impairment with or without cerebellar ataxia 10.7
19 corneal dystrophy, congenital stromal 10.7
20 fibrosis of extraocular muscles, congenital, 3a 10.7
21 duane syndrome type 2 10.7
22 hypomelanotic disorder 10.7
23 isolated ectopia lentis 10.7
24 bornholm eye disease 10.7
25 paralytic squint 10.7
26 anisometropia 10.4
27 prolymphocytic leukemia 10.3 CHN1 DPT
28 tubulointerstitial nephritis with uveitis 10.2 CHN1 TUBB3
29 retinitis 10.2
30 multiple cranial nerve palsy 10.2 MFRP OPTN
31 febrile seizures, familial, 1 10.2 CHN1 TUBB3
32 acute inferoposterior infarction 10.2 MT-ND4 OPTN
33 deep keratitis 10.2 CHN1 OPTN
34 refractive error 10.2
35 ulcerative blepharitis 10.2 MT-ND4 TUBB3
36 endometriosis of ovary 10.2 CHN1 PHOX2A
37 femoral vein thrombophlebitis 10.2 CHN1 DSE OPTN
38 peters anomaly 10.1 OPTN PAX6
39 alopecia areata 10.1 CHN1 PHOX2A TUBB3
40 lingual-facial-buccal dyskinesia 10.1 CHN1 TUBB3
41 total third-nerve palsy 10.1 CHN1 PHOX2A TUBB3
42 joubert syndrome 6 10.1 CHN1 OPTN PAX6
43 mental retardation, autosomal dominant 7 10.1 CHN1 PHOX2A TUBB3
44 myopia 10.1
45 chronic lacrimal gland enlargement 10.1 CHN1 PHOX2A TUBB3
46 urinary bladder villous adenoma 10.1 CHN1 PHOX2A TUBB3
47 fanconi anemia, complementation group d1 10.1 PHOX2A TUBB3
48 allergic contact dermatitis of eyelid 10.1 MFRP MT-ND4 OPTN
49 oliver syndrome 10.1 CHN1 PAX6 TUBB3
50 secondary hypertrophic osteoarthropathy 10.1 CHN1 DPT PLXNA2

Graphical network of the top 20 diseases related to Amblyopia:



Diseases related to Amblyopia

Symptoms & Phenotypes for Amblyopia

UMLS symptoms related to Amblyopia:


other specified visual disturbances, photophobia, blurred vision, visual disturbance

MGI Mouse Phenotypes related to Amblyopia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 PAX6 PHOX2A PLXNA2 SIRPA CHN1 CYCS
2 nervous system MP:0003631 9.28 CHN1 CYCS GRIN1 MFRP PAX6 PHOX2A

Drugs & Therapeutics for Amblyopia

Drugs for Amblyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atropine Approved, Vet_approved Phase 4,Phase 3 5908-99-6, 51-55-8 174174
2
Donepezil Approved Phase 4,Phase 1 120014-06-4 3152
3 Muscarinic Antagonists Phase 4,Phase 3
4 Cholinergic Agents Phase 4,Phase 3,Phase 1
5 Adjuvants, Anesthesia Phase 4,Phase 3
6 Mydriatics Phase 4,Phase 3,Phase 2,Early Phase 1
7 Cholinergic Antagonists Phase 4,Phase 3
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Anesthetics Phase 4,Phase 3
10 Parasympatholytics Phase 4,Phase 3
11 Peripheral Nervous System Agents Phase 4,Phase 3
12 Anti-Arrhythmia Agents Phase 4,Phase 3
13 Anti-Asthmatic Agents Phase 4,Phase 3
14 Respiratory System Agents Phase 4,Phase 3
15 Autonomic Agents Phase 4,Phase 3
16 Bronchodilator Agents Phase 4,Phase 3
17 Cholinesterase Inhibitors Phase 4,Phase 1
18 Nootropic Agents Phase 4,Phase 1
19
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
20
Levodopa Approved Phase 3,Phase 2 59-92-7 6047
21
Carbidopa Approved Phase 3,Phase 2 28860-95-9 34359 38101
22 Dopamine Agents Phase 3,Phase 2
23 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3,Phase 2
24 Antiparkinson Agents Phase 3,Phase 2
25 Central Nervous System Stimulants Phase 1, Phase 2
26
Methamphetamine Approved, Illicit 537-46-2 10836
27
Melphalan Approved 148-82-3 4053 460612
28
Mechlorethamine Approved 51-75-2 4033
29
Ephedrine Approved 299-42-3 9294
30
Pseudoephedrine Approved 90-82-4 7028
31
Glucosamine Approved, Nutraceutical 3416-24-8 439213
32 Adrenergic Agents
33 Curare
34 Neurotransmitter Uptake Inhibitors
35 Dopamine Uptake Inhibitors
36 Anti-Inflammatory Agents
37 Glucuronyl glucosamine glycan sulfate
38 Hypoglycemic Agents
39 Hypolipidemic Agents
40 Fibrinolytic Agents
41 Anticoagulants
42 Lipid Regulating Agents
43 Antimetabolites
44 Alkylating Agents
45 Nitrogen Mustard Compounds
46 Immunosuppressive Agents
47 Antineoplastic Agents, Alkylating
48 Nasal Decongestants
49 Tetrahydrozoline
50 Ophthalmic Solutions

Interventional clinical trials:

(show top 50) (show all 88)
id Name Status NCT ID Phase
1 Trial Comparing Daily Atropine Versus Weekend Atropine Completed NCT00094614 Phase 4
2 Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human Adults Recruiting NCT03109314 Phase 4
3 Vision In Preschoolers Study (VIP Study) Unknown status NCT00038753 Phase 3
4 Levodopa for the Treatment of Residual Amblyopia Completed NCT01190813 Phase 3
5 Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Completed NCT00000170 Phase 3
6 Increasing Patching for Amblyopia in Children 3 to < 8 Years Old Completed NCT00945100 Phase 3
7 Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old Completed NCT00944710 Phase 3
8 Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds Completed NCT00315328 Phase 3
9 Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye for Amblyopia in Children 3 to <7 Years Old Completed NCT00315302 Phase 3
10 Full-time Bangerter Filters Versus Part-time Daily Patching for Moderate Amblyopia in Children Completed NCT00525174 Phase 3
11 An Evaluation of Treatment of Amblyopia in Children 7 To <18 Years Old Completed NCT00094692 Phase 3
12 Bilateral Refractive Amblyopia Treatment Study Completed NCT00305955 Phase 3
13 Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00315198 Phase 3
14 Electronic Recording of Compliance With Occlusion Therapy for Amblyopia Completed NCT00131729 Phase 3
15 Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia Completed NCT00094744 Phase 3
16 Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia Completed NCT00094679 Phase 3
17 Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children Completed NCT00091923 Phase 3
18 Amblyopia (Lazy Eye) Treatment Study Completed NCT00001864 Phase 3
19 Anisometropia Amblyopia Improved by Perceptual Learning and Patching Completed NCT00498641 Phase 3
20 Evaluation of VisionQuest 20/20, a Visual Acuity Testing Software Completed NCT00366756 Phase 3
21 Combined Patching-Atropine for Residual Amblyopia Terminated NCT00506675 Phase 3
22 Trial Comparing Patching With Active Vision Therapy to Patching With Control Vision Therapy as Treatment for Amblyopia Terminated NCT00587171 Phase 3
23 Effectiveness of Telescopic Magnification in the Treatment of Amblyopia Completed NCT00970554 Phase 1, Phase 2
24 Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia Completed NCT00789672 Phase 2
25 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
26 I-BiT - Evaluation of a Novel Binocular Treatment System (I-BiTTM) in Children With Amblyopia Completed NCT01702727 Phase 2
27 Comparison of Photorefraction With Cycloautorefraction and Cycloretinoscopy at Emam Hosein Medical Centre in 2008-2009 Completed NCT00815581 Phase 1, Phase 2
28 An Active Approach to Treat Amblyopia: Perceptual Learning and Video Games Recruiting NCT01115283 Phase 1, Phase 2
29 Caffeine in Amblyopia Study Withdrawn NCT02594358 Phase 1, Phase 2
30 Patching for Lazy Eye: Trial to Evaluate Daily Patching Amounts Completed NCT00274664 Phase 1
31 Visual Cortex Stimulation in Patients With Amblyopia Completed NCT00097162 Phase 1
32 Monovision for the Treatment of Diplopia Completed NCT01426672 Phase 1
33 Treatment of Residual Amblyopia With Donepezil Recruiting NCT01584076 Phase 1
34 Dichoptic Virtual Reality Therapy for Amblyopia in Adults Terminated NCT02246556 Phase 1
35 Vision Screening for the Detection of Amblyopia Unknown status NCT01430247
36 Determining the Efficacy of Full-time Occlusion Therapy in Severe Amblyopia at Different Ages Unknown status NCT02113709
37 Disinvestment Study of Population-Based Vision Screening in Children Unknown status NCT01675193
38 New Pediatric Patching Method to Improve Compliance Unknown status NCT02236351
39 Towards Worldwide Comparability of Visual Acuity Assessment Unknown status NCT01312662
40 Observational Study of Optical Correction for Strabismic Amblyopia in Children 3 to <7 Years Old Completed NCT00669539
41 An Active Approach to Treat Amblyopia: Video Game Play Completed NCT01223716
42 Thickness of Retinal Layers in Amblyopia Completed NCT01179763
43 Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner Completed NCT01726842
44 Multimodal Physician Intervention to Detect Amblyopia Completed NCT01109459
45 Efficacy of Over-glasses Patch Treatment for Amblyopia in Children : OPTA Study Completed NCT03080285
46 Study of Binocular Computer Activities for Treatment of Amblyopia Completed NCT02200211
47 Binocular Treatment of Amblyopia Before and After Strabismus Surgery Completed NCT01791946
48 Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner Completed NCT01832883
49 Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner Completed NCT01706991
50 Evaluation of a Smartphone Application, GoCheckKids™ as a Photo Screening Tool in a Pediatric Population Completed NCT03119675

Search NIH Clinical Center for Amblyopia

Genetic Tests for Amblyopia

Genetic tests related to Amblyopia:

id Genetic test Affiliating Genes
1 Amblyopia 29

Anatomical Context for Amblyopia

MalaCards organs/tissues related to Amblyopia:

39
Eye, Brain, Testes, Cortex, Retina, Pituitary, Occipital Lobe

Publications for Amblyopia

Articles related to Amblyopia:

(show top 50) (show all 722)
id Title Authors Year
1
Neuroplasticity and amblyopia: vision at the balance point. ( 28002122 )
2017
2
Amblyopia Prevention Screening Program in Northwest Iran (Ardabil). ( 27076883 )
2016
3
A Case of Coats Disease and Concurrent Anisometropic Amblyopia. ( 28090595 )
2016
4
The role of Interactive Binocular Treatment system in amblyopia therapy. ( 27830207 )
2016
5
Correction: Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images. ( 27977804 )
2016
6
Fixation Characteristics of Severe Amblyopia Subtypes: Which One is Worse? ( 27191734 )
2016
7
Resolution of anisometropic amblyopia in a 48-year-old with refractive correction alone. ( 27621030 )
2016
8
Perceived Visual Distortions in Juvenile Amblyopes During/Following Routine Amblyopia Treatment. ( 27494346 )
2016
9
Nasolacrimal duct obstruction: Does it really increase the risk of amblyopia in children? ( 27609160 )
2016
10
Prevalence and pattern of amblyopia among primary school pupils in Kosofe town, Lagos state, Nigeria. ( 28000640 )
2016
11
Advantages, limitations, and diagnostic accuracy of photoscreeners in early detection of amblyopia: a review. ( 27555744 )
2016
12
Binocular iPad Game vs Patching for Treatment of Amblyopia in Children: A Randomized Clinical Trial. ( 27832248 )
2016
13
Evaluation of the retinal ganglion cell and choroidal thickness in young Turkish adults with hyperopic anisometropic amblyopia. ( 27255460 )
2016
14
Television Video Games in the Treatment of Amblyopia in Children Aged 4-7 Years. ( 27929727 )
2016
15
Concurrent Investigation of Global Motion and Form Processing in Amblyopia: An Equivalent Noise Approach. ( 27654428 )
2016
16
Amblyopia update: new treatments. ( 27152486 )
2016
17
Binocular Treatment of Amblyopia in Children: Teething Problems on the Path to Clinical Practice. ( 27812701 )
2016
18
"Refractive Errors and Amblyopia in the UCLA Preschool Vision Program; First Year Results". ( 27640004 )
2016
19
Randomised controlled trial of video clips and interactive games to improve vision in children with amblyopia using the I-BiT system. ( 26951772 )
2016
20
New Treatments for Amblyopia-To Patch or Play? ( 27832261 )
2016
21
Paediatric Eye Services: How Much of the Workload Is Amblyopia-Related? ( 27485937 )
2016
22
In vivo optical imaging of amblyopia: Digital subtraction autofluorescence and split-spectrum amplitude-decorrelation angiography. ( 27075555 )
2016
23
Effect of a Binocular iPad Game vs Part-time Patching in Children Aged 5 to 12 Years With Amblyopia: A Randomized Clinical Trial. ( 27812703 )
2016
24
The Initiation of Smooth Pursuit is Delayed in Anisometropic Amblyopia. ( 27070109 )
2016
25
Amblyopia Associated with Congenital Facial Nerve Paralysis. ( 27003874 )
2016
26
Amblyopia: neural basis and therapeutic approaches. ( 27982220 )
2016
27
Analysis of association between type of amblyopia and gender at a tertiary care hospital in Karachi. ( 27183933 )
2016
28
Patient-reported utilities in bilateral visual impairment from amblyopia and age-related macular degeneration. ( 27184381 )
2016
29
"Combined Occlusion and Atropine Therapy" Versus "Augmented Part-Time Patching" in Children with Refractory/Residual Amblyopia: A Pilot Study. ( 27162453 )
2016
30
Visual outcomes after spectacles treatment in children with bilateral high refractive amblyopia. ( 27426739 )
2016
31
Strabismus and Near Point of Convergence and Amblyopia in 4-6 Year-Old Children. ( 27485705 )
2016
32
Visual outcomes after cataract surgery in adults with presumed amblyopia and anisomyopia. ( 27213984 )
2016
33
Imitating the effect of amblyopia on VEP-based acuity estimates. ( 27864655 )
2016
34
Longitudinal Development of Refractive Error in Children With Accommodative Esotropia: Onset, Amblyopia, and Anisometropia. ( 27116548 )
2016
35
Phakic posterior chamber intraocular lens for unilateral high myopic amblyopia in Chinese pediatric patients. ( 28003981 )
2016
36
Risk factors for treatment failure and recurrence of anisometropic amblyopia. ( 27620472 )
2016
37
A pilot randomized clinical trial of intermittent occlusion therapy liquid crystal glasses versus traditional patching for treatment of moderate unilateral amblyopia. ( 27418249 )
2016
38
Fixation preference test: reliability for the detection of amblyopia in patients with strabismus and interexaminer agreement. ( 27933481 )
2016
39
A Meta-Analysis for Association of Maternal Smoking with Childhood Refractive Error and Amblyopia. ( 27247800 )
2016
40
Deficient Binocular Combination of Second-Order Stimuli in Amblyopia. ( 27050880 )
2016
41
Unilateral phthiriasis palpebrarum infestation in a child during occlusion therapy for amblyopia: Case report. ( 26949367 )
2016
42
Crowded letter and crowded picture logMAR acuity in children with amblyopia: a quantitative comparison. ( 27388249 )
2016
43
Properties of new diffusion filters for treatment of amblyopia with accurate occlusive effects. ( 27067873 )
2016
44
Socioeconomic status and utilization of amblyopia services at a tertiary pediatric hospital in Canada. ( 27938957 )
2016
45
Profile of Amblyopia in School going (5-15 years) Children at State Level Referral Hospital in Uttarakhand. ( 28050460 )
2016
46
Amblyopic-related frontal changes in an orientation discrimination task: a research of P3a event-related potentials in anisometropic amblyopia. ( 27895445 )
2016
47
Implementation of an Educational Cartoon ("the Patchbook") and Other Compliance-Enhancing Measures by Orthoptists in Occlusion Treatment of Amblyopia. ( 27486016 )
2016
48
Global motion perception in children with amblyopia as a function of spatial and temporal stimulus parameters. ( 27426263 )
2016
49
Childhood amblyopia: current management and new trends. ( 27543498 )
2016
50
Correlation of the measurements of optical coherence tomography and diffuse tension imaging of optic pathways in amblyopia. ( 27068828 )
2016

Variations for Amblyopia

Expression for Amblyopia

Search GEO for disease gene expression data for Amblyopia.

Pathways for Amblyopia

GO Terms for Amblyopia

Biological processes related to Amblyopia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 respiratory gaseous exchange GO:0007585 9.26 GRIN1 HNMT
2 regulation of axonogenesis GO:0050770 9.16 CHN1 GRIN1
3 eye photoreceptor cell development GO:0042462 8.96 MFRP PAX6
4 regulation of respiratory gaseous exchange GO:0043576 8.62 GRIN1 PHOX2A

Sources for Amblyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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