MCID: AMB002
MIFTS: 49

Amblyopia malady

Eye diseases category
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Summaries for Amblyopia

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Amblyopia, or "lazy eye," is the most common cause of visual impairment in children. it happens when an eye fails to work properly with the brain. the eye may look normal, but the brain favors the other eye. in some cases, it can affect both eyes. causes include strabismus - a disorder in which the two eyes don't line up in the same direction refractive error in an eye - when one eye cannot focus as well as the other, because of a problem with its shape. this includes nearsightedness, farsightedness, and astigmatism. cataract - a clouding in the lens of the eye it can be hard to diagnose amblyopia. it is often found during a routine vision exam. treatment for amblyopia forces the child to use the eye with weaker vision. there are two common ways to do this. one is to have the child wear a patch over the good eye for several hours each day, over a number of weeks to months. the other is with eye drops that temporarily blur vision. each day, the child gets a drop of a drug called atropine in the stronger eye. it is also sometimes necessary to treat the underlying cause. this could include glasses or surgery. nih: national eye institute

MalaCards: Amblyopia, also known as amblyopia, unspecified, is related to anisometropia and suppression amblyopia. An important gene associated with Amblyopia is GRM6 (glutamate receptor, metabotropic 6), and among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone and Taste transduction. The compounds alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and l-glutamic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are nervous system and vision/eye.

Wikipedia:65 Amblyopia (also called lazy eye) is a disorder of sight. It involves decreased vision in an eye that... more...

Aliases & Classifications for Amblyopia

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Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

amblyopia 8 10 34 62
amblyopia, unspecified 8
unspecified amblyopia 8


External Ids:

Disease Ontology8 DOID:10376
MeSH35 D000550
ICD9CM27 368.00

Related Diseases for Amblyopia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amblyopia:



Diseases related to amblyopia

Symptoms for Amblyopia

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Drugs & Therapeutics for Amblyopia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Amblyopia

Search NIH Clinical Center for Amblyopia

Genetic Tests for Amblyopia

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Anatomical Context for Amblyopia

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33MalaCards
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MalaCards organs/tissues related to Amblyopia:

33
Eye, Brain, Testes, Cortex, Retina, Occipital lobe, Pituitary

Animal Models for Amblyopia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Amblyopia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4GRIN1, GRM6, GRM1, ROBO3, PTCH1, GPR17
2MP:00053918.3GRIN1, GRM6, GRM1, DPT, PTCH1
3MP:00053868.1GPR17, PTCH1, ROBO3, GRM1, GRM6, GRIN1

Publications for Amblyopia

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52PubMed
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Articles related to Amblyopia:

(show top 50)    (show all 585)
idTitleAuthorsYear
1
Prevalence, causes and associations of amblyopia in year 1 students in Central China : The Anyang childhood eye study (ACES). (24202959)
2014
2
Retinal nerve fibre layer thickness and macular thickness in patients with esotropic amblyopia. (23421941)
2013
3
A push-pull treatment for strengthening the 'lazy eye' in amblyopia. (23618663)
2013
4
Functional Amblyopia and Deficient Binocular Vision as Initial Clinical Features in Duane's Syndrome. (24063511)
2013
5
A case of amblyopia with contralateral optic nerve hypoplasia. (23331175)
2013
6
Interocular effect during visual acuity measurement with and without amblyopia. (23713923)
2013
7
Effects of atropine on the accommodative system: parameters to consider in its use for penalization treatment of amblyopia. (23521035)
2013
8
Combined optical and atropine treatment of children with residual amblyopia after atropine penalization. (23429575)
2013
9
Treatment for amblyopia after surgery for cataract and vitreoretina in pediatric ocular trauma. (24396958)
2013
10
Identifying potential themes for the Child Amblyopia Treatment Questionnaire. (23628756)
2013
11
Part-time vs. full-time occlusion for amblyopia: evidence for part-time patching. (24260802)
2013
12
Visual functions in amblyopia as determinants of response to treatment. (24102644)
2013
13
Optical treatment of strabismic and combined strabismic-anisometropic amblyopia. (21959371)
2012
14
Visual acuity, crowding, and stereo-vision are linked in children with and without amblyopia. (23074213)
2012
15
Biometric relationships of ocular components in esotropic amblyopia. (22552416)
2012
16
Amblyopia refractive risk factors. (22656894)
2012
17
Effects of l-dopa methyl ester on visual cortex injury induced by amblyopia and its underlying mechanism. (22206838)
2012
18
Frequent Evaluation To Improve Compliance In Patients Treated With Occlusion For Amblyopia: A Randomized controlled Trial. (22989342)
2012
19
Characterization of bangerter filter effect in mild and moderate amblyopia associated with strabismus. (22989340)
2012
20
Effects of anisometropic amblyopia on visuomotor behavior, part 2: visually guided reaching. (21051723)
2011
21
Interocular suppression in strabismic amblyopia results in an attenuated and delayed hemodynamic response function in early visual cortex. (22186274)
2011
22
Unilateral optic nerve sheath meningocele presented with amblyopia. (21800781)
2011
23
Clinical aspects of different types of amblyopia. (21991794)
2011
24
Effects of speed, age, and amblyopia on the perception of motion-defined form. (21911002)
2011
25
Can human amblyopia be treated in adulthood? (21870913)
2011
26
Acupuncture and amblyopia. (21746993)
2011
27
Randomised controlled trial of intermittent photic stimulation for treating amblyopia in older children and adults. (21158885)
2011
28
Idiopathic amblyopia: a diagnosis of exclusion. A report of 3 patients. (21524600)
2011
29
Electrophysiological detection of delayed postretinal neural conduction in human amblyopia. (20463312)
2010
30
Refractory reverse amblyopia with atropine penalization. (21120053)
2010
31
Laterality of amblyopia. (20451898)
2010
32
Foveal function in children treated for amblyopia. (19183413)
2010
33
Charlie Brown, amblyopia, and me: A (not so short) personal history of the past forty years of diagnosing and treating amblyopia. (21061887)
2010
34
Multifocal visual evoked potentials in amblyopia due to anisometropia. (20714361)
2010
35
Selectivity as well as sensitivity loss characterizes the cortical spatial frequency deficit in amblyopia. (19507159)
2009
36
Amblyopia after unilateral infantile cataract extraction after six weeks of age. (20027402)
2009
37
Bilateral uneven cataracts in children: amblyopia management by sequential intraocular lens implantation. (19247388)
2009
38
Cortical mechanisms of normal and abnormal processing in the visual system, Part 1. Spatial vision, amblyopia, hyperacuity, modal assumptions: a review. (19564674)
2009
39
Macular Abnormality Observed by Optical Coherence Tomography in Children with Amblyopia Failing to Achieve Normal Visual Acuity After Long-Term Treatment. (19873949)
2009
40
Long-term efficacy of excimer laser in situ keratomileusis in the management of children with high anisometropic amblyopia. (19493395)
2009
41
Amblyopia masks the scale invariance of normal central vision. (19271892)
2009
42
Pupillography of relative afferent pupillary defects in amblyopia associated with peripapillary myelinated nerve fibers and myopia. (18825905)
2008
43
A pilot study of anisometropic amblyopia improved in adults and children by perceptual learning: an alternative treatment to patching. (18761479)
2008
44
Relationship between anisometropia, patient age, and the development of amblyopia. (17056388)
2006
45
Delayed internal ophthalmoplegia and amblyopia following chickenpox. (16691403)
2006
46
Long-term visual function and relative amblyopia in posterior persistent hyperplastic primary vitreous (PHPV). (16760119)
2006
47
The relationship between anisometropia, patient age, and the development of amblyopia. (17057809)
2005
48
Ametropic amblyopia. (21314500)
1993
49
The practical management of suppression amblyopia. (5089862)
1971
50
The role of orthoptics in amblyopia and abnormal retinal correspondence. (5155083)
1971

Variations for Amblyopia

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Expression for genes affiliated with Amblyopia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amblyopia

Search GEO for disease gene expression data for Amblyopia.

Pathways for genes affiliated with Amblyopia

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 60Thomson Reuters, 53QIAGEN, 12EMD Millipore, 54R&D Systems
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Pathways related to Amblyopia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GRM6, GRM1
2
Show member pathways
9.9GRM1, GRM6
3
Show member pathways
9.9GRIN1, GRM1
4
Show member pathways
9.9GRIN1, GRM1
59.9GRIN1, GRM1
6
Show member pathways
9.6GRM1, GRM6, GRIN1
7
Show member pathways
9.6GRIN1, GRM6, GRM1
8
Show member pathways
9.6GRIN1, GRM6, GRM1
9
Show member pathways
8.7GPR17, PTCH1, GRM1, GRM6, GRIN1

Compounds for genes affiliated with Amblyopia

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Amblyopia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid459.8GRM1, GRIN1
2l-glutamic acid29 24 1111.7GRIN1, GRM6, GRM1
3kainate45 2910.6GRIN1, GRM6, GRM1
4nmda45 2910.6GRIN1, GRM6, GRM1
5glutamate458.8GRIN1, GRM6, GRM1, CSAD

GO Terms for genes affiliated with Amblyopia

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16Gene Ontology
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Cellular components related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.5GRIN1, GRM6, GRM1
2postsynaptic densityGO:0140699.5GRIN1, GRM1, PTCH1
3integral component of plasma membraneGO:0058878.8GPR17, GRM1, GRM6, GRIN1
4plasma membraneGO:0058868.1GRIN1, GRM6, GRM1, SECTM1, PTCH1, GPR17

Biological processes related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:0076269.9GRM6, GRM1
2sensory perception of painGO:0192339.8GRIN1, GRM1
3synaptic transmissionGO:0072689.3GRIN1, GRM6, GRM1

Molecular functions related to Amblyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate receptor activityGO:0080669.9GRM6, GRM1

Products for genes affiliated with Amblyopia

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  • Antibodies
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Sources for Amblyopia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet