Aliases & Classifications for Amblyopia

MalaCards integrated aliases for Amblyopia:

Name: Amblyopia 12 72 28 40 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10376
ICD10 32 H53.00
ICD9CM 34 368.00
MeSH 41 D000550
NCIt 46 C118764
UMLS 69 C0002418

Summaries for Amblyopia

MedlinePlus : 40 Amblyopia, or "lazy eye," is the most common cause of visual impairment in children. It happens when an eye fails to work properly with the brain. The eye may look normal, but the brain favors the other eye. In some cases, it can affect both eyes. Causes include Strabismus - a disorder in which the two eyes don't line up in the same direction Refractive error in an eye - when one eye cannot focus as well as the other, because of a problem with its shape. This includes nearsightedness, farsightedness, and astigmatism. Cataract - a clouding in the lens of the eye It can be hard to diagnose amblyopia. It is often found during a routine vision exam. Treatment for amblyopia forces the child to use the eye with weaker vision. There are two common ways to do this. One is to have the child wear a patch over the good eye for several hours each day, over a number of weeks to months. The other is with eye drops that temporarily blur vision. Each day, the child gets a drop of a drug called atropine in the stronger eye. It is also sometimes necessary to treat the underlying cause. This could include glasses or surgery. NIH: National Eye Institute

MalaCards based summary : Amblyopia is related to ametropic amblyopia and disuse amblyopia, and has symptoms including visual disturbance, photophobia and other specified visual disturbances. An important gene associated with Amblyopia is CHN1 (Chimerin 1), and among its related pathways/superpathways is Neuroscience. The drugs Atropine and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are hearing/vestibular/ear and nervous system

Wikipedia : 72 Amblyopia, also called lazy eye, is a disorder of sight due to the eye and brain not working well... more...

Related Diseases for Amblyopia

Diseases related to Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 ametropic amblyopia 33.9 CHN1 DPT
2 disuse amblyopia 33.4 CHN1 DPT
3 strabismus 32.4 CHN1 SOBP TUBB3
4 duane retraction syndrome 2 32.0 CHN1 MAFB
5 esotropia 32.0 CHN1 OPTN SOBP TUBB3
6 duane syndrome type 2 31.8 CHN1 MAFB
7 congenital ptosis 30.6 CHN1 TUBB3
8 exotropia 30.4 CHN1 TUBB3
9 hypertropia 30.0 CHN1 TUBB3
10 anisometropia 29.8 CHN1 DPT DSE OPTN
11 optic nerve disease 29.3 MFRP MT-ND4 OPTN
12 suppression amblyopia 12.2
13 mental and growth retardation with amblyopia 11.9
14 astigmatism 11.1
15 duane retraction syndrome 1 10.9
16 microphthalmia, isolated 6 10.9
17 cerulean cataract 10.9
18 aniridia 1 10.8
19 aniridia and absent patella 10.8
20 cataract 41 10.8
21 fibrosis of extraocular muscles, congenital, 1 10.8
22 hemifacial hyperplasia with strabismus 10.8
23 albinism, oculocutaneous, type ii 10.8
24 albinism, oculocutaneous, type iii 10.8
25 bornholm eye disease 10.8
26 fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement 10.8
27 corneal dystrophy, congenital stromal 10.8
28 mental retardation, anterior maxillary protrusion, and strabismus 10.8
29 cognitive impairment with or without cerebellar ataxia 10.8
30 duane retraction syndrome 3 with or without deafness 10.8
31 aniridia 2 10.8
32 ocular albinism 10.8
33 hypomelanotic disorder 10.8
34 isolated ectopia lentis 10.8
35 morning glory syndrome 10.8
36 isolated duane retraction syndrome 10.8
37 marcus gunn phenomenon 10.5 CHN1 TUBB3
38 aging 10.4
39 deafness, autosomal dominant 28 10.4 CHN1 TUBB3
40 poland syndrome 10.3 CHN1 TUBB3
41 retinitis 10.3
42 refractive error 10.3
43 paralytic squint 10.3 CHN1 TUBB3
44 duane retraction syndrome 10.3 CHN1 MAFB TUBB3
45 tukel syndrome 10.3 CHN1 TUBB3
46 theileriasis 10.3 MAFB SIRPA
47 acute closed-angle glaucoma 10.2 MFRP OPTN
48 ocular motility disease 10.2 CHN1 TUBB3
49 myopia 10.2
50 hypotropia 10.2 CHN1 OPTN TUBB3

Graphical network of the top 20 diseases related to Amblyopia:



Diseases related to Amblyopia

Symptoms & Phenotypes for Amblyopia

UMLS symptoms related to Amblyopia:


visual disturbance, photophobia, other specified visual disturbances

MGI Mouse Phenotypes related to Amblyopia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.35 GRIN1 MAFB SCN8A SIRPA SOBP
2 nervous system MP:0003631 9.23 CHN1 GRIN1 MAFB MFRP PRSS56 SCN8A

Drugs & Therapeutics for Amblyopia

Drugs for Amblyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atropine Approved, Vet_approved Phase 4,Phase 3 5908-99-6, 51-55-8 174174
2
Donepezil Approved Phase 4,Phase 1 120014-06-4 3152
3 Adjuvants, Anesthesia Phase 4,Phase 3
4 Anesthetics Phase 4,Phase 3
5 Anti-Arrhythmia Agents Phase 4,Phase 3
6 Anti-Asthmatic Agents Phase 4,Phase 3
7 Autonomic Agents Phase 4,Phase 3
8 Bronchodilator Agents Phase 4,Phase 3
9 Cholinergic Agents Phase 4,Phase 3,Phase 1
10 Cholinergic Antagonists Phase 4,Phase 3
11 Muscarinic Antagonists Phase 4,Phase 3
12 Mydriatics Phase 4,Phase 3,Phase 2,Early Phase 1
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Parasympatholytics Phase 4,Phase 3
15 Peripheral Nervous System Agents Phase 4,Phase 3
16 Respiratory System Agents Phase 4,Phase 3
17 Cholinesterase Inhibitors Phase 4,Phase 1
18 Nootropic Agents Phase 4,Phase 1
19
Carbidopa Approved Phase 3,Phase 2 28860-95-9 38101 34359
20
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
21
Levodopa Approved Phase 3,Phase 2 59-92-7 6047
22 Antiparkinson Agents Phase 3,Phase 2
23 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3,Phase 2
24 Dopamine Agents Phase 3,Phase 2
25 Central Nervous System Stimulants Phase 1, Phase 2
26 Omega 3 Fatty Acid Nutraceutical Phase 1, Phase 2
27
Calcium Carbonate Approved, Investigational 471-34-1
28
Methamphetamine Approved, Illicit 537-46-2 10836
29
Mechlorethamine Approved, Investigational 51-75-2 4033
30
Melphalan Approved 148-82-3 460612 4053
31
Ephedrine Approved 299-42-3 9294
32
Pseudoephedrine Approved 90-82-4 7028
33 Tomato Approved, Nutraceutical
34
Glucosamine Approved, Investigational, Nutraceutical 3416-24-8 439213
35 Adrenergic Agents
36 Dopamine Uptake Inhibitors
37 Neurotransmitter Uptake Inhibitors
38 Curare
39 Anti-Inflammatory Agents
40 Anticoagulants
41 Antimetabolites
42 Fibrinolytic Agents
43 Glucuronyl glucosamine glycan sulfate
44 Hypoglycemic Agents
45 Hypolipidemic Agents
46 Lipid Regulating Agents
47 Alkylating Agents
48 Immunosuppressive Agents
49 Nitrogen Mustard Compounds
50 Antihypertensive Agents

Interventional clinical trials:

(show top 50) (show all 97)

# Name Status NCT ID Phase Drugs
1 Trial Comparing Daily Atropine Versus Weekend Atropine Completed NCT00094614 Phase 4 Atropine
2 Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia Recruiting NCT03109314 Phase 4 Donepezil
3 Vision In Preschoolers Study (VIP Study) Unknown status NCT00038753 Phase 3
4 Levodopa for the Treatment of Residual Amblyopia Completed NCT01190813 Phase 3 Levodopa/Carbidopa;Placebo
5 Increasing Patching for Amblyopia in Children 3 to < 8 Years Old Completed NCT00945100 Phase 3
6 Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old Completed NCT00944710 Phase 3 Atropine;Atropine
7 Full-time Bangerter Filters Versus Part-time Daily Patching for Moderate Amblyopia in Children Completed NCT00525174 Phase 3
8 Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds Completed NCT00315328 Phase 3 Atropine
9 Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye for Amblyopia in Children 3 to <7 Years Old Completed NCT00315302 Phase 3 Atropine
10 Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Completed NCT00000170 Phase 3 Atropine
11 Bilateral Refractive Amblyopia Treatment Study Completed NCT00305955 Phase 3
12 An Evaluation of Treatment of Amblyopia in Children 7 To <18 Years Old Completed NCT00094692 Phase 3 atropine
13 Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old Completed NCT00315198 Phase 3
14 Electronic Recording of Compliance With Occlusion Therapy for Amblyopia Completed NCT00131729 Phase 3
15 Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia Completed NCT00094744 Phase 3
16 Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia Completed NCT00094679 Phase 3
17 Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children Completed NCT00091923 Phase 3
18 Amblyopia (Lazy Eye) Treatment Study Completed NCT00001864 Phase 3 Atropine
19 Anisometropia Amblyopia Improved by Perceptual Learning and Patching Completed NCT00498641 Phase 3
20 Evaluation of VisionQuest 20/20, a Visual Acuity Testing Software Completed NCT00366756 Phase 3
21 Combined Patching-Atropine for Residual Amblyopia Terminated NCT00506675 Phase 3 Atropine;Atropine
22 Trial Comparing Patching With Active Vision Therapy to Patching With Control Vision Therapy as Treatment for Amblyopia Terminated NCT00587171 Phase 3
23 Effectiveness of Telescopic Magnification in the Treatment of Amblyopia Completed NCT00970554 Phase 1, Phase 2
24 Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia Completed NCT00789672 Phase 2 levodopa/carbidopa;levodopa/carbidopa
25 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
26 I-BiT - Evaluation of a Novel Binocular Treatment System (I-BiTTM) in Children With Amblyopia Completed NCT01702727 Phase 2
27 Comparison of Photorefraction With Cycloautorefraction and Cycloretinoscopy at Emam Hosein Medical Centre in 2008-2009 Completed NCT00815581 Phase 1, Phase 2
28 An Active Approach to Treat Amblyopia: Perceptual Learning and Video Games Recruiting NCT01115283 Phase 1, Phase 2
29 Docosahexaenoic Acid (DHA) Supplementation in Amblyopia Not yet recruiting NCT03402789 Phase 1, Phase 2 Docosahexaenoic Acid;Placebo Oral Tablet
30 Caffeine in Amblyopia Study Withdrawn NCT02594358 Phase 1, Phase 2 Caffeine
31 Patching for Lazy Eye: Trial to Evaluate Daily Patching Amounts Completed NCT00274664 Phase 1
32 Visual Cortex Stimulation in Patients With Amblyopia Completed NCT00097162 Phase 1
33 Monovision for the Treatment of Diplopia Completed NCT01426672 Phase 1
34 Treatment of Residual Amblyopia With Donepezil Recruiting NCT01584076 Phase 1 Donepezil
35 Dichoptic Virtual Reality Therapy for Amblyopia in Adults Terminated NCT02246556 Phase 1
36 Vision Screening for the Detection of Amblyopia Unknown status NCT01430247
37 Determining the Efficacy of Full-time Occlusion Therapy in Severe Amblyopia at Different Ages Unknown status NCT02113709
38 New Pediatric Patching Method to Improve Compliance Unknown status NCT02236351
39 Towards Worldwide Comparability of Visual Acuity Assessment Unknown status NCT01312662
40 Standard Amblyopia Therapy in Adult Amblyopes Completed NCT03341780
41 Observational Study of Optical Correction for Strabismic Amblyopia in Children 3 to <7 Years Old Completed NCT00669539
42 An Active Approach to Treat Amblyopia: Video Game Play Completed NCT01223716
43 Efficacy of Over-glasses Patch Treatment for Amblyopia in Children : OPTA Study Completed NCT03080285
44 Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner Completed NCT01726842
45 Thickness of Retinal Layers in Amblyopia Completed NCT01179763
46 Study of Binocular Computer Activities for Treatment of Amblyopia Completed NCT02200211
47 Assessment of Device for Treatment of Amblyopia Completed NCT02003235
48 Multimodal Physician Intervention to Detect Amblyopia Completed NCT01109459
49 Binocular Treatment of Amblyopia Before and After Strabismus Surgery Completed NCT01791946
50 Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner Completed NCT01832883

Search NIH Clinical Center for Amblyopia

Genetic Tests for Amblyopia

Genetic tests related to Amblyopia:

# Genetic test Affiliating Genes
1 Amblyopia 28

Anatomical Context for Amblyopia

MalaCards organs/tissues related to Amblyopia:

38
Eye, Brain, Testes, Cortex, Retina, Pituitary, Occipital Lobe

Publications for Amblyopia

Articles related to Amblyopia:

(show top 50) (show all 769)
# Title Authors Year
1
Effectiveness of a Binocular Video Game vs Placebo Video Game for Improving Visual Functions in Older Children, Teenagers, and Adults With Amblyopia: A Randomized Clinical Trial. ( 29302694 )
2018
2
Treatment of amblyopia: Part 2. ( 29436888 )
2018
3
Retinothalamic White Matter Abnormalities in Amblyopia. ( 29450539 )
2018
4
Temporal Ventriloquism Reveals Intact Audiovisual Temporal Integration in Amblyopia. ( 29392305 )
2018
5
Effectiveness of the GoCheck Kids Vision Screener in Detecting Amblyopia Risk Factors. ( 29305313 )
2018
6
Evaluation of the Effects of the Occlu-Pad for the Management of Anisometropic Amblyopia in Children. ( 29451999 )
2018
7
Optimal Audiovisual Integration in the Ventriloquism Effect But Pervasive Deficits in Unisensory Spatial Localization in Amblyopia. ( 29332124 )
2018
8
Optical treatment of amblyopia in older children and adults is essential prior to enrolment in a clinical trial. ( 29356022 )
2018
9
Smartphone Applications for Amblyopia Treatment: A Review of Current Apps and Professional Involvement. ( 29346038 )
2018
10
Lessons From Recent Randomized Clinical Trials of Binocular Treatment for Amblyopia. ( 29302679 )
2018
11
Optical treatment of amblyopia: a systematic review and meta-analysis. ( 29392811 )
2018
12
Comparison of the Thickness and Volume of the Macula and Fovea in Patients with Anisometropic Amblyopia Prior to and after Occlusion Therapy. ( 29376222 )
2018
13
Straatsma syndrome: Satisfactory amblyopia treatment. Report of two cases. ( 29398227 )
2018
14
Two cortical deficits underlie amblyopia: A multifocal fMRI analysis. ( 28943411 )
2017
15
V4B implantable collamer lens versus Intacs corneal rings to manage anisometropic myopic amblyopia in children. ( 28774525 )
2017
16
Pediatric ophthalmology and childhood reading difficulties: Amblyopia and slow reading. ( 28870794 )
2017
17
Analysis of Macular and Retinal Nerve Fiber Layer Thickness in Children with Refractory Amblyopia after Femtosecond Laser-assisted Laser In situ Keratomileusis: A Retrospective Study. ( 28875960 )
2017
18
Spectral-Domain Optical Coherence Tomographic Angiography in Children With Amblyopia. ( 28910439 )
2017
19
Comparison of quantitative measurement of foveal avascular zone and macular vessel density in eyes of children with amblyopia and healthy controls: an optical coherence tomography angiography study. ( 29288839 )
2017
20
Donepezil Does Not Enhance Perceptual Learning in Adults with Amblyopia: A Pilot Study. ( 28824369 )
2017
21
Amblyopia due to intermediate uveitis as the presenting symptom of Crohn's disease in a 6-year-old boy. ( 29102673 )
2017
22
Advances in Amblyopia Treatment: Paradigm Shifts and Future Directions. ( 28885251 )
2017
23
Re: Nutritional optic neuropathy instead of tobacco-alcohol amblyopia. ( 29217037 )
2017
24
Prevalence of amblyopia and its association with refraction in Chinese preschool children aged 36-48 months. ( 28848024 )
2017
25
Refractive error change and vision improvement in moderate to severe hyperopic amblyopia after spectacle correction: Restarting the emmetropization process? ( 28423020 )
2017
26
Observations on the relationship between anisometropia, amblyopia and strabismus. ( 28404522 )
2017
27
Occlusion dose monitoring in amblyopia therapy: status, insights, and future directions. ( 28890077 )
2017
28
CAN Optical Coherence Tomography redefine amblyopia? ( 29450380 )
2017
29
Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography. ( 28915835 )
2017
30
Is the 15a88 Base in Prism Test Reliable for Detection of Amblyopia in Anisometropic Patients? ( 28771067 )
2017
31
The Use of Electronic Devices for the Treatment of Amblyopia. ( 28820929 )
2017
32
Changes in macular parameters in different types of amblyopia: optical coherence tomography study. ( 28831240 )
2017
33
Assessment of an Advanced Vision Screener in the Detection of Amblyopia in the Nebraska Pediatric Population. ( 29257184 )
2017
34
Changes in choroidal blood flow and choroidal thickness after treatment in two cases of pediatric anisohypermetropic amblyopia. ( 29260115 )
2017
35
Treatment of Amblyopia: Part 1. ( 29281565 )
2017
36
Neuroplasticity and amblyopia: vision at the balance point. ( 28002122 )
2017
37
Effect of optical correction on subfoveal choroidal thickness in children with anisohypermetropic amblyopia. ( 29261750 )
2017
38
Nutritional optic neuropathy instead of tobacco-alcohol amblyopia. ( 28985817 )
2017
39
A complete investigation of monocular and binocular functions in clinically treated amblyopia. ( 28878318 )
2017
40
Stereopsis and fusion in anisometropia according to the presence of amblyopia. ( 28889226 )
2017
41
Latent binocular function in amblyopia. ( 28842260 )
2017
42
Diplopia Following Short Treatment for Moderate Amblyopia. ( 28937884 )
2017
43
Editorial: translation of the 1955 monograph by Alfred Bangerter on the treatment of amblyopia. ( 29281567 )
2017
44
Amblyopia and strabismus: trends in prevalence and risk factors among young adults in Israel. ( 28814414 )
2017
45
Myelinated retinal nerve fibre, myopia, and amblyopia syndrome. ( 28774533 )
2017
46
Perceptual learning improves contrast sensitivity, visual acuity, and foveal crowding in amblyopia. ( 28800339 )
2017
47
A pilot randomized clinical trial of intermittent occlusion therapy liquid crystal glasses versus traditional patching for treatment of moderate unilateral amblyopia. ( 27418249 )
2016
48
The role of Interactive Binocular Treatment system in amblyopia therapy. ( 27830207 )
2016
49
Treatment of Amblyopia Using Personalized Dosing Strategies: Statistical Modelling and Clinical Implementation. ( 27929726 )
2016
50
A Case of Coats Disease and Concurrent Anisometropic Amblyopia. ( 28090595 )
2016

Variations for Amblyopia

Expression for Amblyopia

Search GEO for disease gene expression data for Amblyopia.

Pathways for Amblyopia

Pathways related to Amblyopia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.55 FBXO7 GRIN1 OPTN SCN8A TUBB3

GO Terms for Amblyopia

Biological processes related to Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory gaseous exchange GO:0007585 8.96 GRIN1 MAFB
2 regulation of axonogenesis GO:0050770 8.62 CHN1 GRIN1

Sources for Amblyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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