MCID: AML001
MIFTS: 42

Amelanotic Melanoma

Categories: Skin diseases, Cancer diseases

Aliases & Classifications for Amelanotic Melanoma

MalaCards integrated aliases for Amelanotic Melanoma:

Name: Amelanotic Melanoma 12 14
Melanoma, Amelanotic 41 69
Amelanotic Skin Melanoma 69
Melanoma Amelanotic 51

Classifications:



External Ids:

Disease Ontology 12 DOID:4359
MeSH 41 D018328
NCIt 46 C3802
SNOMED-CT 64 70594002
UMLS 69 C0206735

Summaries for Amelanotic Melanoma

MalaCards based summary : Amelanotic Melanoma, also known as melanoma, amelanotic, is related to melanoma and oculocutaneous albinism. An important gene associated with Amelanotic Melanoma is TYR (Tyrosinase), and among its related pathways/superpathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Detoxification of Reactive Oxygen Species. Affiliated tissues include skin, brain and lung, and related phenotypes are behavior/neurological and cellular

Wikipedia : 72 Amelanotic melanoma is a type of skin cancer in which the cells do not make melanin. They can be pink,... more...

Related Diseases for Amelanotic Melanoma

Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 melanoma 30.5 BRAF KIT S100B TYR TYRP1
2 oculocutaneous albinism 30.2 TYR TYRP1
3 vitiligo-associated multiple autoimmune disease susceptibility 1 30.0 CAT TYR TYRP1
4 albinism 29.9 TYR TYRP1
5 skin amelanotic melanoma 12.1
6 malignant spindle cell melanoma 10.3 KIT TYR
7 breast angiosarcoma 10.3 KIT TYR
8 reticular perineurioma 10.3 KIT S100B
9 vulvar melanoma 10.3 KIT TYR
10 mixed type thymoma 10.3 KIT S100B
11 aggressive digital papillary adenocarcinoma 10.3 KIT S100B
12 malignant skin fibrous histiocytoma 10.3 KIT TYR
13 malignant dermis tumor 10.3 KIT TYR
14 tyrosinase-like 10.3 TYR TYRP1
15 perineurioma 10.3 KIT S100B
16 central nervous system melanocytic neoplasm 10.3 KIT TYR
17 embryonal sarcoma 10.3 KIT S100B
18 gonadoblastoma 10.3 CAT KIT
19 polymorphous low-grade adenocarcinoma 10.3 KIT S100B
20 angiomyolipoma 10.2 KIT TYR
21 myopericytoma 10.2 BRAF S100B
22 syringocystadenoma papilliferum 10.2 BRAF S100B
23 hermansky-pudlak syndrome 3 10.2 TYR TYRP1
24 juvenile xanthogranuloma 10.2 BRAF S100B
25 acral lentiginous melanoma 10.2 BRAF KIT
26 mucosal melanoma 10.2 BRAF KIT
27 integumentary system cancer 10.2 KIT TYR
28 neurilemmoma 10.2 KIT S100B
29 histiocytic sarcoma 10.1 BRAF S100B
30 chediak-higashi syndrome 10.1 TYR TYRP1
31 neurofibroma 10.1 KIT S100B
32 ganglioglioma 10.1 BRAF S100B
33 dyschromatosis symmetrica hereditaria 10.1 TYR TYRP1
34 functioning pituitary adenoma 10.1 DRD2 S100B
35 traumatic brain injury 10.1 DRD2 S100B
36 clear cell sarcoma 10.1 KIT S100B
37 choroiditis 10.0
38 adenocarcinoma 10.0
39 pyogenic granuloma 10.0
40 prolactin producing pituitary tumor 10.0 DRD2 TYRP1
41 brain injury 10.0 DRD2 S100B
42 melanoma, uveal 10.0 BRAF S100B TYR
43 dowling-degos disease 1 10.0 KIT TYR TYRP1
44 lentigines 10.0 BRAF KIT TYR
45 waardenburg's syndrome 10.0 KIT TYR TYRP1
46 langerhans cell histiocytosis 10.0 BRAF S100B
47 melanoma metastasis 10.0
48 endotheliitis 10.0
49 bladder transitional cell papilloma 10.0 CYCS PARP1
50 valproate embryopathy 9.9 CAT PARP1

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to Amelanotic Melanoma

Symptoms & Phenotypes for Amelanotic Melanoma

MGI Mouse Phenotypes related to Amelanotic Melanoma:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 S100B TYR TYRP1 PARP1 DRD2 BRAF
2 cellular MP:0005384 10.14 TYR TYRP1 PARP1 DRD2 BRAF KIT
3 homeostasis/metabolism MP:0005376 10.08 TYRP1 S100B TYR PARP1 DRD2 BRAF
4 growth/size/body region MP:0005378 10.05 PARP1 TYRP1 TYR DRD2 BRAF KIT
5 mortality/aging MP:0010768 10.03 TYRP1 TYR PARP1 DRD2 BRAF KIT
6 integument MP:0010771 10 S100B TYR TYRP1 DRD2 BRAF KIT
7 craniofacial MP:0005382 9.92 TYRP1 TYR BRAF KIT CYCS
8 nervous system MP:0003631 9.91 PARP1 TYRP1 TYR DRD2 BRAF KIT
9 hearing/vestibular/ear MP:0005377 9.89 TYRP1 TYR PARP1 BRAF KIT
10 neoplasm MP:0002006 9.88 TYR TYRP1 DRD2 BRAF KIT CAT
11 pigmentation MP:0001186 9.72 TYR TYRP1 DRD2 BRAF KIT
12 renal/urinary system MP:0005367 9.65 PARP1 TYR DRD2 BRAF KIT
13 reproductive system MP:0005389 9.63 PARP1 TYRP1 TYR DRD2 BRAF KIT
14 skeleton MP:0005390 9.43 TYRP1 TYR DRD2 BRAF KIT CYCS
15 vision/eye MP:0005391 9.02 PARP1 TYRP1 TYR BRAF KIT

Drugs & Therapeutics for Amelanotic Melanoma

Search Clinical Trials , NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: melanoma, amelanotic

Genetic Tests for Amelanotic Melanoma

Anatomical Context for Amelanotic Melanoma

MalaCards organs/tissues related to Amelanotic Melanoma:

38
Skin, Brain, Lung, Colon, Testes, Endothelial, Breast

Publications for Amelanotic Melanoma

Articles related to Amelanotic Melanoma:

(show top 50) (show all 253)
# Title Authors Year
1
Noninvasive Gene Expression Testing in Amelanotic Melanoma. ( 29238803 )
2018
2
Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach. ( 28976625 )
2018
3
Congenital amelanotic melanoma in a crossbred heifer calf. ( 28423984 )
2017
4
Primary cutaneous amelanotic melanoma and gastrointestinal stromal tumor in synchronous evolution. ( 29166513 )
2017
5
Participation of Tumor-Associated Myeloid Cells in Progression of Amelanotic Melanoma (RMM Tumor Line) in F344 Rats, with Particular Reference to MHC Class II- and CD163-Expressing Cells. ( 28623530 )
2017
6
Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma. ( 28746718 )
2017
7
An Elusive Amelanotic Melanoma and Review of Dermoscopic Findings. ( 29141067 )
2017
8
Amelanotic Melanoma Arising in Filarial Leg: A Report of a Rare Case. ( 28273977 )
2017
9
Amelanotic melanoma in a child, the importance of suspecting the disease. ( 28636079 )
2017
10
Proteasome inhibitors against amelanotic melanoma. ( 28281027 )
2017
11
Amelanotic melanoma in oculocutaneous albinism: a genetic, dermoscopic and reflectance confocal microscopy study. ( 28555837 )
2017
12
A first reported case of metastatic anorectal amelanotic melanoma with a marked response to anti-PD-1 antibody nivolumab: A case report. ( 28171845 )
2017
13
Unexpected amelanotic melanoma simulators. ( 28106946 )
2017
14
Amelanotic Melanoma in the Vicinity of Acquired Melanocytic Nevi and not Arising from Agminated Melanocytic Nevi: Masquerading as Pyogenic Granuloma. ( 26955141 )
2016
15
Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma. ( 27064601 )
2016
16
Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expression in vivo and in vitro. ( 26949998 )
2016
17
Amelanotic melanoma in the bone marrow. ( 28092878 )
2016
18
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Reversion or promotion of malignancy by inducing melanogenesis or metastasis. ( 27206672 )
2016
19
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated. ( 27206673 )
2016
20
Polarized light dermoscopy to aid in the diagnosis of new pink lesions in an amelanotic melanoma survivor. ( 26568348 )
2015
21
Amelanotic Melanoma Presenting with Plasmacytoid Morphology and BRAF V600 Mutation. ( 26266008 )
2015
22
Amelanotic melanoma mimicking an atypical fibrohistiocytic lesion. ( 25993406 )
2015
23
Amelanotic Melanoma Arising within Conjunctival Melanocytic Intraepithelial Neoplasia Sine Pigmento. ( 26498081 )
2015
24
Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. ( 25500029 )
2015
25
EFFECTS OF ZINGIBER OFFICINALE ROSCOE FRESH EXTRACT ON AMELANOTIC MELANOMA AND NORMAL SKIN FIBROBLASTS. ( 26204672 )
2015
26
Amelanotic melanoma in albinism: the power of dermatoscopy. ( 26290313 )
2015
27
Metastatic amelanotic melanoma with occult primary masquerading as sarcoma. ( 25859510 )
2015
28
BILATERALLY SYMMETRICAL ORAL AMELANOTIC MELANOMA IN A BOA CONSTRICTOR (BOA CONSTRICTOR CONSTRICTOR). ( 26352976 )
2015
29
Intracranial amelanotic melanoma: a case report with literature review. ( 25963017 )
2015
30
Parotid metastasis of an amelanotic melanoma of the scalp: The great masquerader. ( 26348327 )
2015
31
Primary central nervous system amelanotic melanoma in a Hispanic male: Case report. ( 25031666 )
2014
32
Amelanotic melanoma: a case with chr 9 monosomy. ( 24965431 )
2014
33
Oral amelanotic melanoma of the maxilla. ( 25628704 )
2014
34
Amelanotic melanoma mimicking cutaneous epitheliomas. ( 24629365 )
2014
35
Comparative analysis of pathology and boronophenylalanine uptake in experimental orthotopic and heterotopic amelanotic melanoma. ( 24915302 )
2014
36
Amelanotic melanoma masquerading as a pyogenic granuloma: caution warranted. ( 24914083 )
2014
37
Primary amelanotic melanoma of the nasal cavity: a case report. ( 24452896 )
2014
38
A novel BRAF mutation in association with primary amelanotic melanoma with oral metastases. ( 24393566 )
2014
39
Amelanotic melanoma masquerading as a superficial small round cell tumor: a diagnostic challenge. ( 25484414 )
2014
40
Hyporeflective pagetoid cells: A new clue for amelanotic melanoma diagnosis by reflectance confocal microscopy. ( 24329036 )
2013
41
Subungual acrolentiginous amelanotic melanoma treated with amputation of the distal and middle phalanges. ( 23591855 )
2013
42
Proximal atypical lentigo as a clue to amelanotic melanoma: a novel warning sign in the evaluation of monodactylous onychodystrophy. ( 23647618 )
2013
43
Characteristics and survival of patients with invasive amelanotic melanoma in the USA. ( 23883947 )
2013
44
Amelanotic melanoma masquerading as a granular cell lesion. ( 23533832 )
2013
45
The PDT activity of free and pegylated pheophorbide a against an amelanotic melanoma transplanted in C57/BL6 mice. ( 22688292 )
2013
46
Diagnostic usefulness of findings in Doppler sonography for amelanotic melanoma. ( 23802993 )
2013
47
Reflectance confocal microscopy in the diagnosis of partially and completely amelanotic melanoma: report on seven cases. ( 22324783 )
2013
48
BRAF and KIT somatic mutations are present in amelanotic melanoma. ( 23938765 )
2013
49
Amelanotic melanoma mimicking keratoacanthoma: the diagnostic role of dermoscopy. ( 23113565 )
2013
50
Primary amelanotic melanoma of the rectum mimicking adenocarcinoma. ( 23919101 )
2013

Variations for Amelanotic Melanoma

Expression for Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for Amelanotic Melanoma

GO Terms for Amelanotic Melanoma

Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 8.62 TYR TYRP1

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.78 CAT CYCS TYR TYRP1
2 response to UV GO:0009411 9.54 CAT TYR
3 response to cAMP GO:0051591 9.52 BRAF TYR
4 thymus development GO:0048538 9.51 BRAF TYR
5 cellular response to oxidative stress GO:0034599 9.5 CAT CYCS PARP1
6 long-term synaptic potentiation GO:0060291 9.49 BRAF S100B
7 response to radiation GO:0009314 9.46 CAT KIT
8 response to cadmium ion GO:0046686 9.43 CAT KIT
9 melanocyte differentiation GO:0030318 9.4 KIT TYRP1
10 melanin biosynthetic process GO:0042438 9.37 TYR TYRP1
11 visual learning GO:0008542 9.33 BRAF DRD2 KIT
12 myeloid progenitor cell differentiation GO:0002318 9.26 BRAF KIT
13 response to inactivity GO:0014854 8.96 CAT DRD2
14 pigmentation GO:0043473 8.92 DRD2 KIT TYR TYRP1

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.56 BRAF CAT CYCS KIT PARP1 S100B
2 protein heterodimerization activity GO:0046982 9.46 BRAF DRD2 TYR TYRP1
3 protein homodimerization activity GO:0042803 9.1 CAT DRD2 KIT S100B TYR TYRP1

Sources for Amelanotic Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....