Aliases & Classifications for Amelanotic Melanoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH
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Amelanotic Melanoma, Aliases & Descriptions:

Name: Amelanotic Melanoma 9
Melanoma, Amelanotic 60
 
Melanoma Amelanotic 43


External Ids:

Disease Ontology9 DOID:4359
NCIt38 C3802
SNOMED-CT55 70594002
MeSH33 D018328

Summaries for Amelanotic Melanoma

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Wikipedia:63 Amelanotic melanoma is a type of skin cancer in which the cells do not make melanin. They can be... more...

MalaCards based summary: Amelanotic Melanoma, also known as melanoma, amelanotic, is related to oculocutaneous albinism and albinism. An important gene associated with Amelanotic Melanoma is CTSG (cathepsin G), and among its related pathways are Matrix Metalloproteinases and Basal cell carcinoma. The drugs cisplatin and cisplatin pwdr and the compounds kojic acid and mp-11 have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are tumorigenesis and pigmentation.

Related Diseases for Amelanotic Melanoma

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Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1oculocutaneous albinism31.2TYRP1, TYR
2albinism31.1DCT, TYR, TYRP1
3adenocarcinoma30.2TFPI2, TYR, PARP1, ANXA5
4sarcoma30.1S100B, S100A1, CYCS, TYR
5melanoma29.9S100A1, DRD2, ANXA5, PARP1, DCT, CYCS
6lentigo maligna melanoma10.5
7rosai-dorfman disease10.5S100B
8glomus tumor10.4S100A1
9choroiditis10.4
10skin amelanotic melanoma10.4
11chediak-higashi syndrome10.4CTSG, TYR
12waardenburg's syndrome10.3TYRP1, TYR
13ocular albinism10.3TYR, TYRP1
14hermansky-pudlak syndrome10.3TYR, TYRP1
15melanoma metastasis10.3
16pyogenic granuloma10.3
17endotheliitis10.3
18juvenile xanthogranuloma10.3S100B, TYR
19langerhans-cell histiocytosis10.3S100A1, S100B
20cutaneous fibrous histiocytoma10.3S100B, S100A1
21angiomyolipoma10.3TYR, S100A1
22syringoma10.3S100A1, S100B
23myoepithelioma10.3S100A1, S100B
24granular cell tumor10.3S100A1, S100B
25dermatofibrosarcoma protuberans10.3S100A1, S100B
26hemangiopericytoma10.3S100A1, S100B
27malignant mixed mullerian tumor10.2S100A1, S100B
28chordoma10.2S100A1, S100B
29smooth muscle tumor10.2S100A1, S100B
30vitiligo-associated multiple autoimmune disease susceptibility 110.2TYRP1, TYR, DCT
31malignant peripheral nerve sheath tumor10.2S100A1, S100B
32hypothyroidism10.2DCT, TYR, TYRP1
33graves' disease10.2TYRP1, TYR, DCT
34neurofibroma10.2S100A1, S100B
35malignant fibroxanthoma10.2S100A1, S100B
36pleomorphic adenoma10.2S100A1, S100B
37salivary gland adenoid cystic carcinoma10.2S100B, S100A1
38paraganglioma10.2S100A1, S100B
39rothmund-thomson syndrome10.2
40malaria10.2
41burn scar10.2
42burns10.2
43diabetic foot ulcers10.2
44hepatitis10.2
45lichen planus10.2
46nodular hidradenoma10.2
47vulvar melanoma10.2
48lymphosarcoma10.2
49duodenitis10.2
50dysplastic nevus syndrome10.2

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to amelanotic melanoma

Symptoms for Amelanotic Melanoma

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Drugs & Therapeutics for Amelanotic Melanoma

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Drug clinical trials:

Search ClinicalTrials for Amelanotic Melanoma

Search NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Amelanotic Melanoma

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Anatomical Context for Amelanotic Melanoma

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MalaCards organs/tissues related to Amelanotic Melanoma:

31
Skin, Brain, Lung, Colon, Breast, Testes, Endothelial, Eye, Bone, Placenta, Cervix, Tongue

Animal Models for Amelanotic Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Amelanotic Melanoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1CTSG, DRD2, TYR, TYRP1
2MP:00011868.9TYRP1, TYR, DCT, DRD2
3MP:00028738.3TYR, ANXA5, S100A1, S100B, CTSG
4MP:00053868.2TYRP1, TYR, CYCS, DRD2, S100A1, S100B
5MP:00053878.1TYR, CYCS, PARP1, ANXA5, DRD2, CTSG
6MP:00107718.1S100B, DRD2, PARP1, DCT, TYR, TYRP1
7MP:00036317.8TYRP1, TYR, CYCS, DCT, PARP1, DRD2

Publications for Amelanotic Melanoma

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Articles related to Amelanotic Melanoma:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Comparative analysis of pathology and boronophenylalanine uptake in experimental orthotopic and heterotopic amelanotic melanoma. (24915302)
2014
2
Amelanotic melanoma mimicking cutaneous epitheliomas. (24629365)
2014
3
Amelanotic melanoma masquerading as a granular cell lesion. (23533832)
2013
4
Characteristics and survival of patients with invasive amelanotic melanoma in the USA. (23883947)
2013
5
Hyporeflective pagetoid cells: A new clue for amelanotic melanoma diagnosis by reflectance confocal microscopy. (24329036)
2013
6
Vaginal fistula in a patient with relapsed ovarian cancer and amelanotic melanoma. (22593454)
2012
7
Conjunctival amelanotic melanoma--a case report. (22220456)
2011
8
Cytoplasmic immunoreactivity for Ki67 in an invasive amelanotic melanoma--foe or faux pas? (21062343)
2011
9
In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. (20404232)
2010
10
Amelanotic melanoma presenting as contact dermatitis. (20956099)
2010
11
Nodular amelanotic melanoma. (20445300)
2010
12
Malignant amelanotic melanoma of the pleura without primary skin lesion:an autopsy case report. (20035295)
2009
13
Massive cardiac invasion by amelanotic melanoma with obstructive clinical features. (18372490)
2008
14
Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association. (18711275)
2008
15
Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. (19040575)
2008
16
The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. (17312383)
2007
17
Mitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells. (17203890)
2007
18
Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. (16584089)
2006
19
Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study. (16443072)
2006
20
Primary treatment of choroidal amelanotic melanoma with photodynamic therapy--comment. (16970777)
2006
21
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene. (16585201)
2006
22
Immunophenotyping of amelanotic melanoma. A case report. (17053850)
2006
23
The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis. (16314746)
2005
24
Amelanotic melanoma in a child with oculocutaneous albinism. (12825234)
2003
25
Duodenal metastatic amelanotic melanoma. (12838234)
2003
26
Progressive appearance of pigmentation in amelanotic melanoma lesions. (12100494)
2002
27
Complete remission of Bomirski Ab amelanotic melanoma in hamsters treated with the angiogenesis inhibitor TNP-470. (12458330)
2002
28
Tissue distribution and penetration of 5-ALA induced fluorescence in an amelanotic melanoma after topical application. (11299790)
2001
29
Subungual amelanotic melanoma. (10826092)
2000
30
Neurocutaneous melanosis presenting with intracranial amelanotic melanoma. (10219411)
1999
31
Irradiation of amelanotic melanoma cells with 532 nm high peak power pulsed laser radiation in the presence of the photothermal sensitizer Cu(II)-hematoporphyrin: a new approach to cell photoinactivation. (10378011)
1999
32
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. (9877098)
1998
33
Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections. (9720502)
1998
34
Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an amelanotic melanoma in vivo. (9301046)
1997
35
Visualization of uveal amelanotic melanoma with technetium-99m(V) dimercaptosuccinic acid. (9212896)
1997
36
Amelanotic melanoma and hypercalcaemia. (8958374)
1996
37
An epithelioid cell type of amelanotic melanoma of the pinna in a Fischer-344 rat: a case report. (8992617)
1996
38
Amelanotic melanoma. (7632069)
1995
39
Diagnostic ophthalmology. Amelanotic melanoma in an 8-year-old cat. (7585441)
1995
40
Analyses of mixed melanogenesis in tyrosinase cDNA-transfected human amelanotic melanoma cells. (8245515)
1993
41
Amelanotic melanoma presenting as inflammatory plaques. (1401291)
1992
42
The biphasic nature of a human amelanotic melanoma tumour line HT-18. (3151541)
1988
43
Ultrastructural aspects of melanization of hamster Ab amelanotic melanoma in primary cell culture. (2433873)
1986
44
Diagnostic electron microscopy for amelanotic melanoma: correlation of patient biopsy, soft agar assay, and xenograft. (6620008)
1983
45
Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells. (6343885)
1983
46
An amelanotic melanoma transformed into melanotic melanoma with development of vitiligo. (7037894)
1981
47
Comparison of the antigenicity of melanotic and amelanotic melanoma cells after the release of surface glycoproteins by trypsin. (7192976)
1980
48
Junctions of endoplasmic reticulum and virus like intranuclear inclusions and virus like intranuclear inclusions in amelanotic melanoma metastatic to the jejunum. (7414714)
1980
49
Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse). (686981)
1978
50
A clinicopathologic study of amelanotic melanoma. (5086000)
1972

Variations for Amelanotic Melanoma

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Expression for genes affiliated with Amelanotic Melanoma

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Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for genes affiliated with Amelanotic Melanoma

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Pathways related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CTSG, TFPI2
2
Show member pathways
9.2DCT, TYR, TYRP1
3
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
9.2DCT, TYR, TYRP1
49.2ANXA5, S100A1, S100B

Compounds for genes affiliated with Amelanotic Melanoma

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Compounds related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1kojic acid4310.2TYR, TYRP1
2mp-114310.0CYCS, DRD2
3prodigiosin439.9CYCS, PARP1
45,6-Dihydroxyindole-2-carboxylic acid249.9DCT, TYRP1
5myriocin439.9CYCS, PARP1
6alpha-methyl-p-tyrosine439.8TYR, DRD2
7l-dopachrome43 2410.8DCT, TYR
85,6-dihydroxyindole43 2410.8DCT, TYR
9dhica439.7DCT, TYR, TYRP1
10arbutin2 4310.7TYR, TYRP1, DCT
11dopaquinone43 2410.7TYR, TYRP1, DCT
12eumelanin439.7TYRP1, TYR, DCT
13dopachrome439.7DCT, TYRP1, TYR
14hmba439.6TYRP1, DCT, TYR
15sanguinarine439.6PARP1, CYCS, ANXA5
16antimycin a439.6PARP1, CYCS, ANXA5
17betulinic acid43 2810.6ANXA5, PARP1, CYCS
18manumycin439.6PARP1, CYCS, ANXA5
19calpeptin43 5910.5ANXA5, PARP1, CYCS
20s-nitroso-n-acetylpenicillamine439.5CYCS, PARP1, ANXA5
21dutp439.5CYCS, PARP1, ANXA5
22trifluoperazine43 28 49 1212.5CYCS, DRD2, S100A1
23n-(4-hydroxyphenyl)retinamide439.5CYCS, ANXA5, PARP1
24roscovitine439.4ANXA5, PARP1, CYCS
25flavopiridol43 1210.4PARP1, ANXA5, CYCS
26c2ceramide439.3TYR, PARP1, ANXA5, CYCS
27copper43 2410.3S100B, DCT, TYRP1, TYR
283-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.3CYCS, ANXA5, S100B, PARP1
29resveratrol43 59 24 1212.2PARP1, CYCS, TYR, ANXA5
30bortezomib43 49 1211.2ANXA5, PARP1, CYCS
31quercetin43 59 24 1212.2PARP1, CYCS, ANXA5, TYR
32levodopa43 1210.2DRD2, TYRP1, TYR, DCT
33etoposide43 49 59 1212.1ANXA5, CYCS, PARP1, S100B
34sb 20358043 5910.1TYR, CYCS, PARP1, ANXA5
35pdtc439.1CYCS, PARP1, ANXA5
36phospholipid439.0S100A1, CTSG, S100B, ANXA5
37phosphatidylserine43 28 1211.0ANXA5, CYCS, PARP1, S100A1
38ascorbic acid43 2410.0ANXA5, S100B, DRD2, CYCS, TYR
39paclitaxel43 49 1210.9PARP1, ANXA5, S100B, CYCS, TYR
40cycloheximide438.9ANXA5, TYR, CYCS, PARP1, CTSG
41ly294002438.9ANXA5, TYR, CYCS, PARP1
42doxorubicin43 49 1210.9CYCS, PARP1, TYR, ANXA5
43adenylate438.8S100B, TYRP1, DRD2, DCT, TYR
44h2o2438.7CTSG, ANXA5, CYCS, TYR, TYRP1, PARP1
45vegf438.6DRD2, TYR, ANXA5, S100B, PARP1
46cisplatin43 49 59 1211.2DRD2, TYR, CYCS, ANXA5, PARP1, DCT
47oxygen43 249.0S100B, CYCS, TYRP1, TYR, DCT, PARP1
48serine437.7CTSG, S100B, TFPI2, TYRP1, TYR, CYCS
49cysteine437.6PARP1, DCT, S100A1, CYCS, TYR, S100B
50retinoic acid43 248.5DCT, TYR, CYCS, PARP1, ANXA5, S100A1

GO Terms for genes affiliated with Amelanotic Melanoma

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Cellular components related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1melanosomeGO:00424709.2DCT, TYR, TYRP1
2melanosome membraneGO:00331628.9DCT, TYR, TYRP1

Biological processes related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of neuroblast proliferationGO:00020529.4DRD2, DCT
2melanin biosynthetic process from tyrosineGO:00065839.2DCT, TYR

Molecular functions related to Amelanotic Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:00483069.6S100B, S100A1
2S100 protein bindingGO:00445489.5S100A1, S100B
3copper ion bindingGO:00055079.2DCT, TYR, TYRP1
4protein homodimerization activityGO:00428038.6S100B, S100A1, DRD2, TYR, TYRP1
5identical protein bindingGO:00428028.3S100B, S100A1, DRD2, PARP1

Products for genes affiliated with Amelanotic Melanoma

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Sources for Amelanotic Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet