MCID: AML001
MIFTS: 50

Amelanotic Melanoma malady

Summaries for Amelanotic Melanoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Amelanotic melanoma is a type of skin cancer in which the cells do not make melanin. They can be... more...

MalaCards: Amelanotic Melanoma, also known as melanoma, amelanotic, is related to melanoma and albinism. An important gene associated with Amelanotic Melanoma is TYR (tyrosinase), and among its related pathways are Phenylalanine metabolism and Basal cell carcinoma. The drugs cisplatin and cisplatin pwdr and the compounds kojic acid and mp-11 have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are pigmentation and immune system.

Aliases & Classifications for Amelanotic Melanoma

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

amelanotic melanoma 8
melanoma, amelanotic 60
melanoma amelanotic 44


External Ids:

Disease Ontology8 DOID:4359
NCIt39 C3802
SNOMED-CT56 70594002
MeSH34 D018328

Related Diseases for Amelanotic Melanoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to amelanotic melanoma

Clinical Features for Amelanotic Melanoma

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Drugs & Therapeutics for Amelanotic Melanoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Amelanotic Melanoma

Drug clinical trials:

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Search NIH Clinical Center for Amelanotic Melanoma

Search CenterWatch for Amelanotic Melanoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Amelanotic Melanoma

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Anatomical Context for Amelanotic Melanoma

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32MalaCards
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MalaCards organs/tissues related to Amelanotic Melanoma:

32
Skin, Brain, Lung, Colon, Endothelial, Breast, Testes, Cervix, Placenta, Eye, Bone, Tongue

Animal Models for Amelanotic Melanoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Amelanotic Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.7DCT
2MP:00053877.8PARP1, SLC4A1, CYCS, TYR, ANXA5, DRD2
3MP:00107717.6PARP1, SLC4A1, TYRP1, TYR, DCT, DRD2

Publications for Amelanotic Melanoma

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50PubMed
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Articles related to Amelanotic Melanoma:

(show top 50)    (show all 244)
idTitleAuthorsYear
1
A novel BRAF mutation in association with primary amelanotic melanoma with oral metastases. (24393566)
2014
2
Primary amelanotic melanoma of the rectum mimicking adenocarcinoma. (23919101)
2013
3
Nodular amelanotic melanoma. (20445300)
2010
4
Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. (20398822)
2010
5
Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. (19525876)
2009
6
Malignant amelanotic melanoma developing from an intradermal naevus in a patient with oculocutaneous albinism. (19486065)
2009
7
Anorectal amelanotic melanoma. (17944970)
2008
8
Primary amelanotic melanoma of the vagina. (18787356)
2008
9
A cystic amelanotic melanoma metastasis to the brain: case report. (18726049)
2008
10
C-kit positive amelanotic melanoma of the oesophagus: a potential diagnostic pitfall. (18604743)
2008
11
The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. (17312383)
2007
12
Case report: amelanotic melanoma located on the lower extremity. (18092703)
2007
13
Dermoscopic vascular patterns in nodular "pure" amelanotic melanoma. (17438200)
2007
14
Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice. (17987514)
2007
15
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene. (16585201)
2006
16
Immunophenotyping of amelanotic melanoma. A case report. (17053850)
2006
17
The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis. (16314746)
2005
18
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. (16087843)
2005
19
Multiple skin metastases of amelanotic melanoma originating from the sinonasal mucosa. (16396817)
2005
20
Amelanotic melanoma in a child with oculocutaneous albinism. (12825234)
2003
21
Progressive appearance of pigmentation in amelanotic melanoma lesions. (12100494)
2002
22
Amelanotic subungual melanoma mimicking pyogenic granuloma in the hand. (12363192)
2002
23
Recurrent lentigo maligna as amelanotic lentigo maligna melanoma. (12428849)
2002
24
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase. (11775059)
2001
25
Irradiation of amelanotic melanoma cells with 532 nm high peak power pulsed laser radiation in the presence of the photothermal sensitizer Cu(II)-hematoporphyrin: a new approach to cell photoinactivation. (10378011)
1999
26
Amelanotic lentigo maligna melanoma: a unique case presentation. (10469082)
1999
27
Amelanotic lentigo maligna and amelanotic lentigo maligna melanoma: a report of three cases mimicking intraepidermal squamous carcinoma. (9731974)
1998
28
Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential. (8145526)
1994
29
Amelanotic metastatic melanoma in a patient with oculocutaneous albinism. (8491890)
1993
30
Plasmodium falciparum: the effect of pH and Ca2+ concentration on the in vitro cytoadherence of infected erythrocytes to amelanotic melanoma cells. (1915750)
1991
31
Cytomorphology of metastatic melanoma--use of S-100 protein in the diagnosis of amelanotic melanoma. (1782361)
1991
32
Amelanotic melanoma metastatic to the epiglottis. (1919354)
1991
33
Amelanotic lentigo maligna melanoma: a unique case and review of the literature. (2666033)
1989
34
L-tyrosine, L-dopa, and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma cells. (2497448)
1989
35
Axillary sweat gland carcinoma versus amelanotic malignant melanoma. (4089996)
1985
36
Some properties of Bomirski Ab amelanotic melanoma cells, which underwent spontaneous melanization in primary cell culture. Growth kinetics, cell morphology, melanin content and tumorigenicity. (3972882)
1985
37
Arrest and extravasation of B16 amelanotic melanoma in murine lungs. A light and electron microscopic study. (4046557)
1985
38
Lack of effect of in vivo prostacyclin on the development of pulmonary metastases in mice following intravenous injection of CT26 colon carcinoma, Lewis lung carcinoma, or B16 amelanotic melanoma cells. (6378376)
1984
39
Immunohistochemical and histochemical tools in the diagnosis of amelanotic melanoma. (6365305)
1984
40
Amelanotic melanoma presenting as Bowen's disease. (6630703)
1983
41
Recurrent amelanotic lentigo maligna melanoma: a case report. (6640933)
1983
42
Studies on amelanotic melanoma with the fluorescence method (Falck and Hillarp) and biochemical analysis of 5-S-cysteinyldopa in the tissues. (6419680)
1983
43
Noncontact detection of experimental amelanotic ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine. (6915722)
1981
44
Comparison of the antigenicity of melanotic and amelanotic melanoma cells after the release of surface glycoproteins by trypsin. (7192976)
1980
45
Amelanotic melanoma (tapioca melanoma) of the iris. (532814)
1979
46
Amelanotic melanoma. (1197756)
1975
47
Four types of cellular fine structure associated with human amelanotic melanoma. (4779129)
1973
48
A clinicopathologic study of amelanotic melanoma. (5086000)
1972
49
Amelanotic melanoma; case report. (13295183)
1956
50
The cytology of the typical and the amelanotic melanoma. (18862171)
1948

Genetic Variations for Amelanotic Melanoma

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Expression for genes affiliated with Amelanotic Melanoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amelanotic Melanoma

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Pathways for genes affiliated with Amelanotic Melanoma

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29KEGG, 4Cell Signaling Technology
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Pathways related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4TYRP1, TYR, DCT
2
Hide members
9.4TYRP1, TYR, DCT
38.9ANXA5, S100A1, S100B

Compounds for genes affiliated with Amelanotic Melanoma

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44Novoseek, 24HMDB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB
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Compounds related to Amelanotic Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1kojic acid4410.2TYRP1, TYR
2mp-114410.1DRD2, CYCS
3l-dopachrome44 2411.0DCT, TYR
4prodigiosin4410.0PARP1, CYCS
5alpha-methyl-p-tyrosine4410.0DRD2, TYR
6myriocin449.9CYCS, PARP1
75,6-dihydroxyindole44 2410.9TYR, DCT
8dhica449.8DCT, TYR, TYRP1
9arbutin2 4410.8TYRP1, TYR, DCT
10dopaquinone44 2410.8TYRP1, TYR, DCT
11eumelanin449.8TYRP1, DCT, TYR
12dopachrome449.8TYRP1, DCT, TYR
13hmba449.8TYR, DCT, TYRP1
14cycloheximide449.6TYR, PARP1, CTSG
15sanguinarine449.6CYCS, PARP1, ANXA5
16antimycin a449.6CYCS, PARP1, ANXA5
17betulinic acid44 2810.6ANXA5, CYCS, PARP1
18manumycin449.6ANXA5, CYCS, PARP1
19calpeptin44 5910.6PARP1, CYCS, ANXA5
20s-nitroso-n-acetylpenicillamine449.5PARP1, CYCS, ANXA5
21dutp449.5ANXA5, PARP1, CYCS
22n-(4-hydroxyphenyl)retinamide449.5ANXA5, PARP1, CYCS
23copper44 2410.4TYRP1, TYR, DCT, S100B
24levodopa44 1110.4TYRP1, TYR, DCT, DRD2
25roscovitine449.4PARP1, ANXA5, CYCS
26c2ceramide449.4CYCS, TYR, ANXA5, PARP1
273-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.3CYCS, S100B, ANXA5, PARP1
28resveratrol44 59 11 2412.3PARP1, ANXA5, CYCS, TYR
29quercetin44 59 11 2412.3ANXA5, TYR, CYCS, PARP1
30trifluoperazine44 28 1111.3DRD2, CYCS, S100A1
31flavopiridol44 1110.3PARP1, CYCS, ANXA5
32pdtc449.2ANXA5, CYCS, PARP1
33ascorbic acid44 2410.2TYR, ANXA5, DRD2, S100B, CYCS
34peroxynitrite449.1SLC4A1, CYCS, PARP1
35paclitaxel44 49 1111.0PARP1, S100B, ANXA5, CYCS, TYR
36lactate449.0S100B, SLC4A1, CYCS, ANXA5, CTSG
37etoposide44 49 59 1112.0ANXA5, CYCS, PARP1, S100B
38hydrogen44 2410.0S100B, S100A1, CTSG, SLC4A1
39adenylate449.0S100B, DRD2, DCT, TYR, TYRP1
40sb 20358044 599.9PARP1, ANXA5, CYCS, TYR
41bortezomib44 119.9ANXA5, CYCS, PARP1
42h2o2448.7ANXA5, PARP1, CYCS, TYRP1, CTSG, TYR
43phosphatidylserine44 28 1110.7S100A1, ANXA5, PARP1, CYCS
44phospholipid448.6S100B, S100A1, CTSG, ANXA5, SLC4A1
45cisplatin44 49 59 1111.5TYR, PARP1, ANXA5, CYCS, DRD2, DCT
46atp44 289.4S100B, SLC4A1, PARP1, CYCS, CTSG, ANXA5
47oxygen44 249.2CYCS, S100B, PARP1, ANXA5, TYR, DCT
48tyrosine447.6TYRP1, S100A1, DCT, ANXA5, TYR, SLC4A1
49retinoic acid44 248.5CTSG, PARP1, CYCS, TYR, ANXA5, DCT
50cysteine447.1CTSG, S100B, S100A1, DCT, TYR, TYRP1

GO Terms for genes affiliated with Amelanotic Melanoma

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16Gene Ontology
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Cellular components related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosomeGO:0424709.4TYRP1, TYR, DCT
2melanosome membraneGO:0331629.1TYRP1, TYR, DCT

Biological processes related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of neuroblast proliferationGO:0020529.6DCT, DRD2
2melanin biosynthetic process from tyrosineGO:0065839.4TYR, DCT

Molecular functions related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.4TYRP1, TYR, DCT
2S100 protein bindingGO:0445489.1S100A1, S100B
3identical protein bindingGO:0428028.5PARP1, DRD2, S100A1, S100B
4protein homodimerization activityGO:0428038.2S100B, S100A1, TYR, TYRP1, SLC4A1

Products for genes affiliated with Amelanotic Melanoma

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Sources for Amelanotic Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet