MCID: AML001
MIFTS: 53

Amelanotic Melanoma malady

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Summaries for Amelanotic Melanoma

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Wikipedia:65 Amelanotic melanoma is a type of skin cancer in which the cells do not make melanin. They can be... more...

MalaCards based summary: Amelanotic Melanoma, also known as melanoma, amelanotic, is related to oculocutaneous albinism and albinism. An important gene associated with Amelanotic Melanoma is CTSG (cathepsin G), and among its related pathways are Matrix Metalloproteinases and Basal cell carcinoma. The drugs cisplatin and cisplatin pwdr and the compounds kojic acid and mp-11 have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are tumorigenesis and pigmentation.

Aliases & Classifications for Amelanotic Melanoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Amelanotic Melanoma, Aliases & Descriptions:

Name: Amelanotic Melanoma 8
Melanoma, Amelanotic 62
 
Melanoma Amelanotic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4359
NCIt39 C3802
SNOMED-CT57 70594002
MeSH34 D018328

Related Diseases for Amelanotic Melanoma

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Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1oculocutaneous albinism31.2TYR, TYRP1
2albinism31.1DCT, TYR, TYRP1
3vitiligo30.8DCT, TYRP1, TYR
4adenocarcinoma30.2ANXA5, PARP1, TFPI2, TYR
5melanoma29.9CYCS, DRD2, DCT, PARP1, ANXA5, S100B
6lentigo maligna melanoma10.5
7rosai-dorfman disease10.5S100B
8choroiditis10.4
9chediak-higashi syndrome10.4CTSG, TYR
10waardenburg's syndrome10.3TYRP1, TYR
11ocular albinism10.3TYR, TYRP1
12hermansky-pudlak syndrome10.3TYRP1, TYR
13juvenile xanthogranuloma10.3S100B, TYR
14melanoma metastasis10.3
15skin amelanotic melanoma10.3
16pyogenic granuloma10.3
17endotheliitis10.3
18langerhans-cell histiocytosis10.3S100A1, S100B
19cutaneous fibrous histiocytoma10.3S100A1, S100B
20angiomyolipoma10.3S100A1, TYR
21syringoma10.3S100A1, S100B
22myoepithelioma10.3S100A1, S100B
23dermatofibrosarcoma protuberans10.3S100B, S100A1
24granular cell tumor10.3S100A1, S100B
25hemangiopericytoma10.3S100A1, S100B
26malignant mixed mullerian tumor10.3S100B, S100A1
27chordoma10.2S100A1, S100B
28smooth muscle tumor10.2S100B, S100A1
29malignant peripheral nerve sheath tumor10.2S100A1, S100B
30hypothyroidism10.2DCT, TYRP1, TYR
31graves' disease10.2DCT, TYR, TYRP1
32pleomorphic adenoma10.2S100B, S100A1
33malignant fibroxanthoma10.2S100B, S100A1
34neurofibroma10.2S100A1, S100B
35salivary gland adenoid cystic carcinoma10.2S100B, S100A1
36gastrointestinal stromal tumor10.2S100B, S100A1
37burn scar10.2
38burns10.2
39diabetic foot ulcers10.2
40hepatitis10.2
41malaria10.2
42lichen planus10.2
43rothmund-thomson syndrome10.2
44nodular hidradenoma10.2
45vulvar melanoma10.2
46plasmodium falciparum malaria10.2
47dysplastic nevus syndrome10.2
48xeroderma pigmentosum10.2
49lymphosarcoma10.2
50duodenitis10.2

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to amelanotic melanoma

Symptoms for Amelanotic Melanoma

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Drugs & Therapeutics for Amelanotic Melanoma

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Drug clinical trials:

Search ClinicalTrials for Amelanotic Melanoma

Search NIH Clinical Center for Amelanotic Melanoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Amelanotic Melanoma

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Anatomical Context for Amelanotic Melanoma

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MalaCards organs/tissues related to Amelanotic Melanoma:

32
Skin, Brain, Lung, Colon, Breast, Testes, Endothelial, Eye, Bone, Placenta, Cervix, Tongue

Animal Models for Amelanotic Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Amelanotic Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1CTSG, DRD2, TYR, TYRP1
2MP:00011868.9TYRP1, TYR, DCT, DRD2
3MP:00028738.3TYR, ANXA5, S100A1, S100B, CTSG
4MP:00053868.2TYRP1, TYR, CYCS, DRD2, S100A1, S100B
5MP:00053878.1TYR, CYCS, PARP1, ANXA5, DRD2, CTSG
6MP:00107718.1S100B, DRD2, PARP1, DCT, TYR, TYRP1
7MP:00036317.8TYRP1, TYR, CYCS, DCT, PARP1, DRD2

Publications for Amelanotic Melanoma

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Articles related to Amelanotic Melanoma:

(show top 50)    (show all 215)
idTitleAuthorsYear
1
Comparative analysis of pathology and boronophenylalanine uptake in experimental orthotopic and heterotopic amelanotic melanoma. (24915302)
2014
2
Amelanotic melanoma mimicking cutaneous epitheliomas. (24629365)
2014
3
Amelanotic melanoma masquerading as a granular cell lesion. (23533832)
2013
4
Characteristics and survival of patients with invasive amelanotic melanoma in the USA. (23883947)
2013
5
Hyporeflective pagetoid cells: A new clue for amelanotic melanoma diagnosis by reflectance confocal microscopy. (24329036)
2013
6
Conjunctival amelanotic melanoma--a case report. (22220456)
2011
7
Cytoplasmic immunoreactivity for Ki67 in an invasive amelanotic melanoma--foe or faux pas? (21062343)
2011
8
In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. (20404232)
2010
9
Amelanotic melanoma presenting as contact dermatitis. (20956099)
2010
10
Nodular amelanotic melanoma. (20445300)
2010
11
Malignant amelanotic melanoma of the pleura without primary skin lesion:an autopsy case report. (20035295)
2009
12
Massive cardiac invasion by amelanotic melanoma with obstructive clinical features. (18372490)
2008
13
Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association. (18711275)
2008
14
Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. (19040575)
2008
15
The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. (17312383)
2007
16
Mitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells. (17203890)
2007
17
Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. (16584089)
2006
18
Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study. (16443072)
2006
19
Primary treatment of choroidal amelanotic melanoma with photodynamic therapy--comment. (16970777)
2006
20
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene. (16585201)
2006
21
Immunophenotyping of amelanotic melanoma. A case report. (17053850)
2006
22
Polymorphous vascular patterns in dermoscopy as a sign of malignant skin tumors. A case of an amelanotic melanoma and a porocarcinoma. (15604548)
2005
23
The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis. (16314746)
2005
24
Amelanotic melanoma in a child with oculocutaneous albinism. (12825234)
2003
25
Duodenal metastatic amelanotic melanoma. (12838234)
2003
26
Progressive appearance of pigmentation in amelanotic melanoma lesions. (12100494)
2002
27
Complete remission of Bomirski Ab amelanotic melanoma in hamsters treated with the angiogenesis inhibitor TNP-470. (12458330)
2002
28
Tissue distribution and penetration of 5-ALA induced fluorescence in an amelanotic melanoma after topical application. (11299790)
2001
29
Subungual amelanotic melanoma. (10826092)
2000
30
Neurocutaneous melanosis presenting with intracranial amelanotic melanoma. (10219411)
1999
31
Irradiation of amelanotic melanoma cells with 532 nm high peak power pulsed laser radiation in the presence of the photothermal sensitizer Cu(II)-hematoporphyrin: a new approach to cell photoinactivation. (10378011)
1999
32
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. (9877098)
1998
33
Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections. (9720502)
1998
34
Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an amelanotic melanoma in vivo. (9301046)
1997
35
Visualization of uveal amelanotic melanoma with technetium-99m(V) dimercaptosuccinic acid. (9212896)
1997
36
Amelanotic melanoma and hypercalcaemia. (8958374)
1996
37
An epithelioid cell type of amelanotic melanoma of the pinna in a Fischer-344 rat: a case report. (8992617)
1996
38
Amelanotic melanoma. (7632069)
1995
39
Diagnostic ophthalmology. Amelanotic melanoma in an 8-year-old cat. (7585441)
1995
40
Analyses of mixed melanogenesis in tyrosinase cDNA-transfected human amelanotic melanoma cells. (8245515)
1993
41
Amelanotic melanoma presenting as inflammatory plaques. (1401291)
1992
42
A primary amelanotic melanoma of the vagina diagnosed by immunocytochemistry. (2568292)
1989
43
The biphasic nature of a human amelanotic melanoma tumour line HT-18. (3151541)
1988
44
Ultrastructural aspects of melanization of hamster Ab amelanotic melanoma in primary cell culture. (2433873)
1986
45
Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells. (6343885)
1983
46
An amelanotic melanoma transformed into melanotic melanoma with development of vitiligo. (7037894)
1981
47
Comparison of the antigenicity of melanotic and amelanotic melanoma cells after the release of surface glycoproteins by trypsin. (7192976)
1980
48
Junctions of endoplasmic reticulum and virus like intranuclear inclusions and virus like intranuclear inclusions in amelanotic melanoma metastatic to the jejunum. (7414714)
1980
49
Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse). (686981)
1978
50
A clinicopathologic study of amelanotic melanoma. (5086000)
1972

Variations for Amelanotic Melanoma

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Expression for genes affiliated with Amelanotic Melanoma

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Expression patterns in normal tissues for genes affiliated with Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for genes affiliated with Amelanotic Melanoma

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Pathways related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CTSG, TFPI2
2
Show member pathways
9.2TYR, DCT, TYRP1
3
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.2DCT, TYR, TYRP1
49.2S100A1, S100B, ANXA5

Compounds for genes affiliated with Amelanotic Melanoma

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Compounds related to Amelanotic Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1kojic acid4410.2TYR, TYRP1
2mp-114410.0CYCS, DRD2
3prodigiosin449.9CYCS, PARP1
45,6-Dihydroxyindole-2-carboxylic acid249.9DCT, TYRP1
5myriocin449.9CYCS, PARP1
6alpha-methyl-p-tyrosine449.8TYR, DRD2
7l-dopachrome44 2410.8DCT, TYR
85,6-dihydroxyindole44 2410.8DCT, TYR
9dhica449.7DCT, TYR, TYRP1
10arbutin2 4410.7TYR, TYRP1, DCT
11dopaquinone44 2410.7TYR, TYRP1, DCT
12eumelanin449.7TYRP1, TYR, DCT
13dopachrome449.7DCT, TYRP1, TYR
14hmba449.6TYRP1, DCT, TYR
15sanguinarine449.6PARP1, CYCS, ANXA5
16antimycin a449.6PARP1, CYCS, ANXA5
17betulinic acid44 2810.6ANXA5, PARP1, CYCS
18manumycin449.6PARP1, CYCS, ANXA5
19calpeptin44 6110.5ANXA5, PARP1, CYCS
20s-nitroso-n-acetylpenicillamine449.5CYCS, PARP1, ANXA5
21dutp449.5CYCS, PARP1, ANXA5
22trifluoperazine44 28 50 1112.5CYCS, DRD2, S100A1
23n-(4-hydroxyphenyl)retinamide449.5CYCS, ANXA5, PARP1
24roscovitine449.4ANXA5, PARP1, CYCS
25flavopiridol44 1110.4PARP1, ANXA5, CYCS
26c2ceramide449.3TYR, PARP1, ANXA5, CYCS
27copper44 2410.3S100B, DCT, TYRP1, TYR
283-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.3CYCS, ANXA5, S100B, PARP1
29resveratrol44 61 24 1112.2PARP1, CYCS, TYR, ANXA5
30bortezomib44 50 1111.2ANXA5, PARP1, CYCS
31quercetin44 61 24 1112.2PARP1, CYCS, ANXA5, TYR
32levodopa44 1110.2DRD2, TYRP1, TYR, DCT
33etoposide44 50 61 1112.1ANXA5, CYCS, PARP1, S100B
34sb 20358044 6110.1TYR, CYCS, PARP1, ANXA5
35pdtc449.1CYCS, PARP1, ANXA5
36phospholipid449.0S100A1, CTSG, S100B, ANXA5
37phosphatidylserine44 28 1111.0ANXA5, CYCS, PARP1, S100A1
38ascorbic acid44 2410.0ANXA5, S100B, DRD2, CYCS, TYR
39paclitaxel44 50 1110.9PARP1, ANXA5, S100B, CYCS, TYR
40cycloheximide448.9ANXA5, TYR, CYCS, PARP1, CTSG
41ly294002448.9ANXA5, TYR, CYCS, PARP1
42doxorubicin44 50 1110.9CYCS, PARP1, TYR, ANXA5
43adenylate448.8S100B, TYRP1, DRD2, DCT, TYR
44h2o2448.7CTSG, ANXA5, CYCS, TYR, TYRP1, PARP1
45vegf448.6DRD2, TYR, ANXA5, S100B, PARP1
46cisplatin44 50 61 1111.2DRD2, TYR, CYCS, ANXA5, PARP1, DCT
47oxygen44 249.0S100B, CYCS, TYRP1, TYR, DCT, PARP1
48serine447.7CTSG, S100B, TFPI2, TYRP1, TYR, CYCS
49cysteine447.6PARP1, DCT, S100A1, CYCS, TYR, S100B
50retinoic acid44 248.5DCT, TYR, CYCS, PARP1, ANXA5, S100A1

GO Terms for genes affiliated with Amelanotic Melanoma

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Cellular components related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosomeGO:0424709.2DCT, TYR, TYRP1
2melanosome membraneGO:0331628.9DCT, TYR, TYRP1

Biological processes related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of neuroblast proliferationGO:0020529.4DRD2, DCT
2melanin biosynthetic process from tyrosineGO:0065839.2DCT, TYR

Molecular functions related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:0483069.6S100B, S100A1
2S100 protein bindingGO:0445489.5S100A1, S100B
3copper ion bindingGO:0055079.2DCT, TYR, TYRP1
4protein homodimerization activityGO:0428038.6S100B, S100A1, DRD2, TYR, TYRP1
5identical protein bindingGO:0428028.3S100B, S100A1, DRD2, PARP1

Products for genes affiliated with Amelanotic Melanoma

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Sources for Amelanotic Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet