MCID: AML001
MIFTS: 53

Amelanotic Melanoma malady

Cancer diseases category

Summaries for Amelanotic Melanoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Amelanotic melanoma is a type of skin cancer in which the cells do not make melanin. They can be... more...

MalaCards: Amelanotic Melanoma, also known as melanoma, amelanotic, is related to melanoma and albinism. An important gene associated with Amelanotic Melanoma is CTSG (cathepsin G), and among its related pathways are Matrix Metalloproteinases and Basal cell carcinoma. The drugs cisplatin and cisplatin pwdr and the compounds kojic acid and mp-11 have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are tumorigenesis and pigmentation.

Aliases & Classifications for Amelanotic Melanoma

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9Disease Ontology, 46Novoseek, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

amelanotic melanoma 9
melanoma, amelanotic 63
melanoma amelanotic 46


External Ids:

Disease Ontology9 DOID:4359
NCIt41 C3802
SNOMED-CT59 70594002
MeSH36 D018328

Related Diseases for Amelanotic Melanoma

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18GeneCards, 19GeneDecks
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Diseases related to Amelanotic Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.5CYCS, DRD2, DCT, PARP1, ANXA5, S100B
2albinism30.8DCT, TYR, TYRP1
3oculocutaneous albinism30.8TYR, TYRP1
4vitiligo30.5DCT, TYRP1, TYR
5adenocarcinoma30.5ANXA5, PARP1, TFPI2, TYR
6ovarian cancer30.0TYR, PARP1, ANXA5, DRD2, CYCS
7lentigo maligna melanoma10.5
8choroiditis10.4
9skin amelanotic melanoma10.3
10endotheliitis10.3
11diabetic foot ulcers10.1
12burn scar10.1
13burns10.1
14rothmund-thomson syndrome10.1
15lichen planus10.1
16nodular hidradenoma10.1
17vulvar melanoma10.1
18lymphosarcoma10.1
19duodenitis10.1
20dysplastic nevus syndrome10.1
21xeroderma pigmentosum10.1
22plasmodium falciparum malaria10.1
23cervicitis10.1
24colon adenocarcinoma10.1
25contact dermatitis10.1
26cystic teratoma10.1
27dermatitis10.1
28giant cell tumor10.1
29hepatitis10.1
30hidradenoma10.1
31keratoacanthoma10.1
32liposarcoma10.1
33malaria10.1
34ophthalmoplegia10.1
35papilloma10.1
36vaginitis10.1
37neurocutaneous melanosis10.1
38ocular melanoma10.1
39pyogenic granuloma10.1
40teratoma10.1
41rosai-dorfman disease10.1S100B
42glomus tumor10.1S100A1
43chediak-higashi syndrome10.1CTSG, TYR
44waardenburg's syndrome10.1TYRP1, TYR
45ocular albinism10.1TYR, TYRP1
46hermansky-pudlak syndrome10.1TYRP1, TYR
47juvenile xanthogranuloma10.1S100B, TYR
48langerhans-cell histiocytosis10.1S100A1, S100B
49cutaneous fibrous histiocytoma10.1S100A1, S100B
50angiomyolipoma10.1S100A1, TYR

Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to amelanotic melanoma

Symptoms for Amelanotic Melanoma

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Drugs & Therapeutics for Amelanotic Melanoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Amelanotic Melanoma

Drug clinical trials:

Search ClinicalTrials for Amelanotic Melanoma

Search NIH Clinical Center for Amelanotic Melanoma

Search CenterWatch for Amelanotic Melanoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Amelanotic Melanoma

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Anatomical Context for Amelanotic Melanoma

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34MalaCards
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MalaCards organs/tissues related to Amelanotic Melanoma:

34
Skin, Brain, Lung, Colon, Endothelial, Breast, Testes, Eye, Bone, Placenta, Tongue, Cervix

Animal Models for Amelanotic Melanoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Amelanotic Melanoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1TYRP1, DRD2, CTSG, TYR
2MP:00011868.9TYRP1, DRD2, DCT, TYR
3MP:00028738.3S100B, S100A1, ANXA5, CTSG, TYR
4MP:00053868.2DRD2, TYR, CYCS, S100A1, S100B, TYRP1
5MP:00053878.1CYCS, TYR, PARP1, ANXA5, DRD2, CTSG
6MP:00107718.1TYR, TYRP1, DCT, PARP1, S100B, DRD2
7MP:00036317.8TYRP1, TYR, CYCS, DCT, PARP1, DRD2

Publications for Amelanotic Melanoma

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53PubMed
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Articles related to Amelanotic Melanoma:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Amelanotic melanoma masquerading as a granular cell lesion. (23533832)
2013
2
Characteristics and survival of patients with invasive amelanotic melanoma in the USA. (23883947)
2013
3
Hyporeflective pagetoid cells: A new clue for amelanotic melanoma diagnosis by reflectance confocal microscopy. (24329036)
2013
4
Vaginal fistula in a patient with relapsed ovarian cancer and amelanotic melanoma. (22593454)
2012
5
Conjunctival amelanotic melanoma--a case report. (22220456)
2011
6
Cytoplasmic immunoreactivity for Ki67 in an invasive amelanotic melanoma--foe or faux pas? (21062343)
2011
7
In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. (20404232)
2010
8
Amelanotic melanoma presenting as contact dermatitis. (20956099)
2010
9
Nodular amelanotic melanoma. (20445300)
2010
10
True amelanotic melanoma: the great masquerader. (19713163)
2010
11
Malignant amelanotic melanoma of the pleura without primary skin lesion:an autopsy case report. (20035295)
2009
12
Massive cardiac invasion by amelanotic melanoma with obstructive clinical features. (18372490)
2008
13
Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association. (18711275)
2008
14
Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. (19040575)
2008
15
The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. (17312383)
2007
16
Mitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells. (17203890)
2007
17
Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. (16584089)
2006
18
Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study. (16443072)
2006
19
Primary treatment of choroidal amelanotic melanoma with photodynamic therapy--comment. (16970777)
2006
20
Immunophenotyping of amelanotic melanoma. A case report. (17053850)
2006
21
Polymorphous vascular patterns in dermoscopy as a sign of malignant skin tumors. A case of an amelanotic melanoma and a porocarcinoma. (15604548)
2005
22
The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis. (16314746)
2005
23
Amelanotic melanoma in a child with oculocutaneous albinism. (12825234)
2003
24
Duodenal metastatic amelanotic melanoma. (12838234)
2003
25
Progressive appearance of pigmentation in amelanotic melanoma lesions. (12100494)
2002
26
Complete remission of Bomirski Ab amelanotic melanoma in hamsters treated with the angiogenesis inhibitor TNP-470. (12458330)
2002
27
Tissue distribution and penetration of 5-ALA induced fluorescence in an amelanotic melanoma after topical application. (11299790)
2001
28
Subungual amelanotic melanoma. (10826092)
2000
29
Neurocutaneous melanosis presenting with intracranial amelanotic melanoma. (10219411)
1999
30
Irradiation of amelanotic melanoma cells with 532 nm high peak power pulsed laser radiation in the presence of the photothermal sensitizer Cu(II)-hematoporphyrin: a new approach to cell photoinactivation. (10378011)
1999
31
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. (9877098)
1998
32
Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections. (9720502)
1998
33
Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an amelanotic melanoma in vivo. (9301046)
1997
34
Visualization of uveal amelanotic melanoma with technetium-99m(V) dimercaptosuccinic acid. (9212896)
1997
35
Amelanotic melanoma and hypercalcaemia. (8958374)
1996
36
An epithelioid cell type of amelanotic melanoma of the pinna in a Fischer-344 rat: a case report. (8992617)
1996
37
Amelanotic melanoma. (7632069)
1995
38
Diagnostic ophthalmology. Amelanotic melanoma in an 8-year-old cat. (7585441)
1995
39
Analyses of mixed melanogenesis in tyrosinase cDNA-transfected human amelanotic melanoma cells. (8245515)
1993
40
Amelanotic melanoma presenting as inflammatory plaques. (1401291)
1992
41
A primary amelanotic melanoma of the vagina diagnosed by immunocytochemistry. (2568292)
1989
42
The biphasic nature of a human amelanotic melanoma tumour line HT-18. (3151541)
1988
43
Ultrastructural aspects of melanization of hamster Ab amelanotic melanoma in primary cell culture. (2433873)
1986
44
Diagnostic electron microscopy for amelanotic melanoma: correlation of patient biopsy, soft agar assay, and xenograft. (6620008)
1983
45
Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells. (6343885)
1983
46
An amelanotic melanoma transformed into melanotic melanoma with development of vitiligo. (7037894)
1981
47
Comparison of the antigenicity of melanotic and amelanotic melanoma cells after the release of surface glycoproteins by trypsin. (7192976)
1980
48
Junctions of endoplasmic reticulum and virus like intranuclear inclusions and virus like intranuclear inclusions in amelanotic melanoma metastatic to the jejunum. (7414714)
1980
49
Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse). (686981)
1978
50
A clinicopathologic study of amelanotic melanoma. (5086000)
1972

Variations for Amelanotic Melanoma

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Expression for genes affiliated with Amelanotic Melanoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amelanotic Melanoma

Search GEO for disease gene expression data for Amelanotic Melanoma.

Pathways for genes affiliated with Amelanotic Melanoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 31KEGG, 5Cell Signaling Technology
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Pathways related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CTSG, TFPI2
2
Show member pathways
9.2TYR, DCT, TYRP1
3
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.2DCT, TYR, TYRP1
49.2S100A1, S100B, ANXA5

Compounds for genes affiliated with Amelanotic Melanoma

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46Novoseek, 25HMDB, 3BitterDB, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 12DrugBank
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Compounds related to Amelanotic Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1kojic acid4610.2TYR, TYRP1
2mp-114610.0CYCS, DRD2
3prodigiosin469.9CYCS, PARP1
45,6-Dihydroxyindole-2-carboxylic acid259.9DCT, TYRP1
5myriocin469.9CYCS, PARP1
6alpha-methyl-p-tyrosine469.8TYR, DRD2
7l-dopachrome46 2510.8DCT, TYR
85,6-dihydroxyindole46 2510.8DCT, TYR
9dhica469.7DCT, TYR, TYRP1
10arbutin3 4610.7TYR, TYRP1, DCT
11dopaquinone46 2510.7TYR, TYRP1, DCT
12eumelanin469.7TYRP1, TYR, DCT
13dopachrome469.7DCT, TYRP1, TYR
14hmba469.6TYRP1, DCT, TYR
15sanguinarine469.6PARP1, CYCS, ANXA5
16antimycin a469.6PARP1, CYCS, ANXA5
17betulinic acid46 3010.6ANXA5, PARP1, CYCS
18manumycin469.6PARP1, CYCS, ANXA5
19calpeptin46 6210.5ANXA5, PARP1, CYCS
20s-nitroso-n-acetylpenicillamine469.5CYCS, PARP1, ANXA5
21dutp469.5CYCS, PARP1, ANXA5
22trifluoperazine46 30 52 1212.5CYCS, DRD2, S100A1
23n-(4-hydroxyphenyl)retinamide469.5CYCS, ANXA5, PARP1
24roscovitine469.4ANXA5, PARP1, CYCS
25flavopiridol46 1210.4PARP1, ANXA5, CYCS
26c2ceramide469.3TYR, PARP1, ANXA5, CYCS
27copper46 2510.3S100B, DCT, TYRP1, TYR
283-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.3CYCS, ANXA5, S100B, PARP1
29resveratrol46 62 25 1212.2PARP1, CYCS, TYR, ANXA5
30bortezomib46 52 1211.2ANXA5, PARP1, CYCS
31quercetin46 62 25 1212.2PARP1, CYCS, ANXA5, TYR
32levodopa46 1210.2DRD2, TYRP1, TYR, DCT
33etoposide46 52 62 1212.1ANXA5, CYCS, PARP1, S100B
34sb 20358046 6210.1TYR, CYCS, PARP1, ANXA5
35pdtc469.1CYCS, PARP1, ANXA5
36phospholipid469.0S100A1, CTSG, S100B, ANXA5
37phosphatidylserine46 30 1211.0ANXA5, CYCS, PARP1, S100A1
38ascorbic acid46 2510.0ANXA5, S100B, DRD2, CYCS, TYR
39paclitaxel46 52 1210.9PARP1, ANXA5, S100B, CYCS, TYR
40cycloheximide468.9ANXA5, TYR, CYCS, PARP1, CTSG
41ly294002468.9ANXA5, TYR, CYCS, PARP1
42doxorubicin46 52 1210.9CYCS, PARP1, TYR, ANXA5
43adenylate468.8S100B, TYRP1, DRD2, DCT, TYR
44h2o2468.7CTSG, ANXA5, CYCS, TYR, TYRP1, PARP1
45vegf468.6DRD2, TYR, ANXA5, S100B, PARP1
46cisplatin46 52 62 1211.2DRD2, TYR, CYCS, ANXA5, PARP1, DCT
47oxygen46 259.0S100B, CYCS, TYRP1, TYR, DCT, PARP1
48serine467.7CTSG, S100B, TFPI2, TYRP1, TYR, CYCS
49cysteine467.6PARP1, DCT, S100A1, CYCS, TYR, S100B
50retinoic acid46 258.5DCT, TYR, CYCS, PARP1, ANXA5, S100A1

GO Terms for genes affiliated with Amelanotic Melanoma

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17Gene Ontology
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Cellular components related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosomeGO:0424709.2DCT, TYR, TYRP1
2melanosome membraneGO:0331628.9DCT, TYR, TYRP1

Biological processes related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of neuroblast proliferationGO:0020529.4DRD2, DCT
2melanin biosynthetic process from tyrosineGO:0065839.2DCT, TYR

Molecular functions related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:0483069.6S100B, S100A1
2S100 protein bindingGO:0445489.5S100A1, S100B
3copper ion bindingGO:0055079.2DCT, TYR, TYRP1
4protein homodimerization activityGO:0428038.6S100A1, TYRP1, TYR, DRD2, S100B
5identical protein bindingGO:0428028.3PARP1, S100B, S100A1, DRD2

Products for genes affiliated with Amelanotic Melanoma

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Sources for Amelanotic Melanoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet