MCID: AML001
MIFTS: 50

Amelanotic Melanoma malady

Summaries for Amelanotic Melanoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Amelanotic melanoma is a type of skin cancer in which the cells do not make melanin. They can be... more...

MalaCards: Amelanotic Melanoma, also known as melanoma, amelanotic, is related to melanoma and albinism. An important gene associated with Amelanotic Melanoma is TYR (tyrosinase), and among its related pathways are Phenylalanine metabolism and Basal cell carcinoma. The drugs cisplatin and cisplatin pwdr and the compounds kojic acid and mp-11 have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and brain, and related mouse phenotypes are pigmentation and immune system.

Aliases & Classifications for Amelanotic Melanoma

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

amelanotic melanoma 8
melanoma, amelanotic 60
melanoma amelanotic 44


External Ids:

Disease Ontology8 DOID:4359
NCIt39 C3802
SNOMED-CT56 70594002
MeSH34 D018328

Related Diseases for Amelanotic Melanoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amelanotic Melanoma:



Diseases related to amelanotic melanoma

Clinical Features for Amelanotic Melanoma

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Drugs & Therapeutics for Amelanotic Melanoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Amelanotic Melanoma

Drug clinical trials:

Search ClinicalTrials for Amelanotic Melanoma

Search NIH Clinical Center for Amelanotic Melanoma

Search CenterWatch for Amelanotic Melanoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Amelanotic Melanoma

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Anatomical Context for Amelanotic Melanoma

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32MalaCards
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MalaCards organs/tissues related to Amelanotic Melanoma:

32
Skin, Lung, Brain, Colon, Endothelial, Breast, Testes, Eye, Tongue, Bone, Placenta, Cervix

Animal Models for Amelanotic Melanoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Amelanotic Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.7DCT
2MP:00053877.8PARP1, SLC4A1, CYCS, TYR, ANXA5, DRD2
3MP:00107717.6PARP1, SLC4A1, TYRP1, TYR, DCT, DRD2

Publications for Amelanotic Melanoma

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50PubMed
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Articles related to Amelanotic Melanoma:

(show top 50)    (show all 244)
idTitleAuthorsYear
1
BRAF and KIT somatic mutations are present in amelanotic melanoma. (23938765)
2013
2
Oral malignant melanoma detected after resection of amelanotic pulmonary metastasis. (24189568)
2013
3
Diffuse Gastroduodenal Metastasis from Cutaneous Malignant Melanoma Presenting as Amelanotic "Volcano-Like" Ulcers. (23775060)
2013
4
Vaginal fistula in a patient with relapsed ovarian cancer and amelanotic melanoma. (22593454)
2012
5
Conjunctival amelanotic melanoma--a case report. (22220456)
2011
6
Metastatic amelanotic melanoma of larynx-hypopharynx. (21493402)
2011
7
Amelanotic melanoma presenting as contact dermatitis. (20956099)
2010
8
True amelanotic melanoma: the great masquerader. (19713163)
2010
9
Malignant amelanotic melanoma of the pleura without primary skin lesion:an autopsy case report. (20035295)
2009
10
Amelanotic malignant melanoma of the esophagus: report of two cases with immunohistochemical and molecular genetic study of KIT and PDGFRA. (19496203)
2009
11
Effusion cytomorphology and immunocytochemistry of malignant melanoma: five cases of melanotic melanoma and one case of amelanotic melanoma. (19301358)
2009
12
Amelanotic melanoma presenting with cervical lymphadenopathy. (21686931)
2009
13
Metastasis of amelanotic melanoma of unknown origin in the parotid gland. (19167137)
2009
14
Rhinophymatous amelanotic melanoma. (17569401)
2007
15
Primary treatment of choroidal amelanotic melanoma with photodynamic therapy--comment. (16970777)
2006
16
Bilateral diffuse melanocytic proliferation associated with ovarian carcinoma and metastatic malignant amelanotic melanoma. (17011873)
2006
17
Choroidal amelanotic melanoma in a patient with oculocutaneous albinism. (16391642)
2005
18
Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma. (16112378)
2005
19
Experimental photodynamic therapy with MESO-tetrakisphenylporphyrin (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice. (12494481)
2003
20
A rare case of intracranial metastatic amelanotic melanoma with cyst. (12835304)
2003
21
Testing your diagnostic skills. Case no. 1. Amelanotic melanoma. (12929504)
2003
22
Metastatic amelanotic melanoma. (12385549)
2002
23
Effect of boron neutron capture therapy for melanotic and amelanotic melanoma transplanted into mouse brain. (11837459)
2002
24
Amelanotic melanoma masquerading as an ingrown toenail. (12015412)
2002
25
Tissue distribution and penetration of 5-ALA induced fluorescence in an amelanotic melanoma after topical application. (11299790)
2001
26
Activation of melanogenesis by vacuolar type H(+)-ATPase inhibitors in amelanotic, tyrosinase positive human and mouse melanoma cells. (10922469)
2000
27
Neurocutaneous melanosis presenting with intracranial amelanotic melanoma. (10219411)
1999
28
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. (9877098)
1998
29
Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections. (9720502)
1998
30
Cytodiagnosis of metastatic amelanotic melanomas by fine-needle aspiration biopsy: adjunctival value of immunocytochemistry and electron microscopy. (9570211)
1998
31
Amelanotic lentigo maligna melanoma of the face: a case report and review of the literature. (9499607)
1997
32
Photodynamic eradication of amelanotic melanoma of the hamster with fast acting photosensitizers. (8567124)
1996
33
Amelanotic melanoma. (7632069)
1995
34
Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster. (8286189)
1994
35
In vivo kinetics and spectra of 5-aminolaevulinic acid-induced fluorescence in an amelanotic melanoma of the hamster. (7947087)
1994
36
Amelanotic melanoma of the oral cavity. (8410206)
1993
37
Protein-kinase-C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization. (1379995)
1992
38
Primary intracranial amelanotic melanoma--report of an autopsy case. (1726225)
1991
39
Subungual amelanotic melanoma: a diagnostic pitfall. (2362886)
1990
40
A primary amelanotic melanoma of the vagina diagnosed by immunocytochemistry. (2568292)
1989
41
The biphasic nature of a human amelanotic melanoma tumour line HT-18. (3151541)
1988
42
Monoclonal antibody against human tyrosinase and reactive with melanotic and amelanotic melanoma cells. (3127479)
1988
43
Ultrastructural aspects of melanization of hamster Ab amelanotic melanoma in primary cell culture. (2433873)
1986
44
Cytologic diagnosis of amelanotic melanoma. (3859154)
1985
45
Uptake of 123I-5-iodo-2-thiouracil, a possible radiopharmaceutical for noninvasive detection of ocular melanoma, in melanotic and amelanotic melanomas in hamsters. (4088550)
1985
46
Effect of antiplatelet antibody on the development of pulmonary metastases following injection of CT26 colon adenocarcinoma, Lewis lung carcinoma, and B16 amelanotic melanoma tumor cells into mice. (6744304)
1984
47
Capillary blood flow in the amelanotic melanoma of the hamster after isovolemic hemodilution. (6487763)
1984
48
Amelanotic lentigo maligna melanoma manifesting as a dermatitislike plaque. (6847222)
1983
49
Malignant amelanotic melanoma--a rare tumor. (6955465)
1982
50
Possible primary amelanotic melanoma of the oral cavity. (6945405)
1981

Genetic Variations for Amelanotic Melanoma

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Expression for genes affiliated with Amelanotic Melanoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amelanotic Melanoma

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Pathways for genes affiliated with Amelanotic Melanoma

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29KEGG, 4Cell Signaling Technology
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Pathways related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.4TYRP1, TYR, DCT
2
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9.4TYRP1, TYR, DCT
38.9ANXA5, S100A1, S100B

Compounds for genes affiliated with Amelanotic Melanoma

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44Novoseek, 24HMDB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB
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Compounds related to Amelanotic Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1kojic acid4410.2TYR, TYRP1
2mp-114410.1DRD2, CYCS
3l-dopachrome44 2411.0DCT, TYR
4alpha-methyl-p-tyrosine4410.0TYR, DRD2
5prodigiosin4410.0CYCS, PARP1
6myriocin449.9CYCS, PARP1
75,6-dihydroxyindole44 2410.9TYR, DCT
8dhica449.8DCT, TYR, TYRP1
9arbutin2 4410.8TYRP1, TYR, DCT
10dopaquinone44 2410.8DCT, TYR, TYRP1
11eumelanin449.8TYRP1, TYR, DCT
12dopachrome449.8TYRP1, TYR, DCT
13hmba449.8DCT, TYR, TYRP1
14cycloheximide449.6CTSG, TYR, PARP1
15sanguinarine449.6PARP1, CYCS, ANXA5
16antimycin a449.6ANXA5, CYCS, PARP1
17betulinic acid44 2810.6PARP1, CYCS, ANXA5
18manumycin449.6ANXA5, CYCS, PARP1
19calpeptin44 5910.6PARP1, CYCS, ANXA5
20s-nitroso-n-acetylpenicillamine449.5ANXA5, CYCS, PARP1
21dutp449.5PARP1, CYCS, ANXA5
22n-(4-hydroxyphenyl)retinamide449.5PARP1, CYCS, ANXA5
23copper44 2410.4TYRP1, TYR, DCT, S100B
24levodopa44 1110.4DRD2, DCT, TYR, TYRP1
25roscovitine449.4PARP1, CYCS, ANXA5
26c2ceramide449.4ANXA5, TYR, CYCS, PARP1
273-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.3S100B, ANXA5, CYCS, PARP1
28resveratrol44 59 11 2412.3PARP1, CYCS, TYR, ANXA5
29quercetin44 59 11 2412.3ANXA5, TYR, CYCS, PARP1
30trifluoperazine44 28 1111.3CYCS, DRD2, S100A1
31flavopiridol44 1110.3PARP1, CYCS, ANXA5
32pdtc449.2PARP1, CYCS, ANXA5
33ascorbic acid44 2410.2S100B, DRD2, ANXA5, TYR, CYCS
34peroxynitrite449.1PARP1, SLC4A1, CYCS
35paclitaxel44 49 1111.0S100B, ANXA5, TYR, CYCS, PARP1
36lactate449.0S100B, CTSG, ANXA5, CYCS, SLC4A1
37etoposide44 49 59 1112.0S100B, ANXA5, CYCS, PARP1
38hydrogen44 2410.0S100B, S100A1, CTSG, SLC4A1
39adenylate449.0S100B, DRD2, DCT, TYR, TYRP1
40sb 20358044 599.9ANXA5, TYR, CYCS, PARP1
41bortezomib44 119.9ANXA5, CYCS, PARP1
42h2o2448.7CTSG, ANXA5, TYR, TYRP1, CYCS, PARP1
43phosphatidylserine44 28 1110.7S100A1, ANXA5, CYCS, PARP1
44phospholipid448.6S100B, S100A1, CTSG, ANXA5, SLC4A1
45cisplatin44 49 59 1111.5DRD2, DCT, ANXA5, TYR, CYCS, PARP1
46atp44 289.4S100B, CTSG, ANXA5, CYCS, SLC4A1, PARP1
47oxygen44 249.2S100B, DCT, ANXA5, TYR, TYRP1, CYCS
48tyrosine447.6S100B, S100A1, DCT, ANXA5, TYR, TYRP1
49retinoic acid44 248.5S100B, S100A1, CTSG, DCT, ANXA5, TYR
50cysteine447.1PARP1, S100B, S100A1, CTSG, DCT, TYR

GO Terms for genes affiliated with Amelanotic Melanoma

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16Gene Ontology
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Cellular components related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosomeGO:0424709.4TYRP1, TYR, DCT
2melanosome membraneGO:0331629.1TYRP1, TYR, DCT

Biological processes related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of neuroblast proliferationGO:0020529.6DCT, DRD2
2melanin biosynthetic process from tyrosineGO:0065839.4TYR, DCT

Molecular functions related to Amelanotic Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.4TYRP1, TYR, DCT
2S100 protein bindingGO:0445489.1S100A1, S100B
3identical protein bindingGO:0428028.5PARP1, DRD2, S100A1, S100B
4protein homodimerization activityGO:0428038.2S100B, S100A1, TYR, TYRP1, SLC4A1

Products for genes affiliated with Amelanotic Melanoma

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Sources for Amelanotic Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet