MCID: AML004
MIFTS: 27

Ameloblastic Carcinoma malady

Cancer diseases category

Summaries for Ameloblastic Carcinoma

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Ameloblastic carcinoma is a rare oral cancer that commonly develops towards the back of the lower or upper jaw. the cancer can develop spontaneously or arise from a preexisting ameloblastoma.  a common early symptom is swelling. the underlying cause of the cancer is not well understood.  last updated: 10/19/2011

MalaCards: Ameloblastic Carcinoma is related to spindle cell carcinoma and papillary carcinoma. An important gene associated with Ameloblastic Carcinoma is MUC1 (mucin 1, cell surface associated), and among its related pathways are TP53 network and DNA Damage. The compounds mucicarmine and acetone have been mentioned in the context of this disorder. Related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Ameloblastic Carcinoma

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Sources:
42NIH Rare Diseases, 48Orphanet, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
ameloblastic carcinoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

ameloblastic carcinoma 42 48 60


Related Diseases for Ameloblastic Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ameloblastic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1spindle cell carcinoma30.5TP63, MUC1
2papillary carcinoma30.1MUC1, MKI67, TP63
3hypercalcemia10.1
4cervical cancer10.0CDKN2A
5keratoacanthoma10.0MKI67
6oral cancer10.0CDKN2A
7leukoplakia10.0MKI67
8laryngeal benign neoplasm10.0MKI67
9osteosarcoma10.0CDKN2A
10angiosarcoma10.0MUC1
11chordoma10.0MUC1
12benign meningioma10.0MKI67
13eccrine porocarcinoma10.0MUC1
14leiomyoma10.0MKI67
15cholangiocarcinoma10.0MUC1
16leukemia10.0CDKN2A
17smooth muscle tumor10.0MKI67
18chondrosarcoma10.0MUC1
19colon cancer10.0CDKN2A
20esophageal cancer10.0CDKN2A
21actinic keratosis10.0TP63
22neurofibroma10.0MUC1
23rhabdoid tumor10.0MUC1
24endometrial carcinoma10.0CDKN2A, MKI67
25cervical intraepithelial neoplasia10.0CDKN2A, MKI67
26retinoblastoma10.0MKI67, CDKN2A
27hepatocellular carcinoma10.0CDKN2A, MKI67
28pancreatic cancer10.0CDKN2A, MUC1
29ependymoma10.0MKI67, MUC1
30ovarian cancer10.0MUC1, CDKN2A
31meningioma10.0MUC1, MKI67
32barrett's esophagus10.0CDKN2A, MKI67
33malignant peripheral nerve sheath tumor10.0MUC1, CDKN2A
34bladder carcinoma10.0CDKN2A, MKI67
35malignant fibroxanthoma10.0MKI67, MUC1
36synovial sarcoma10.0MUC1, MKI67
37papilloma10.0CDKN2A, TP63
38oral leukoplakia10.0MKI67, TP63
39phyllode tumor10.0MKI67, TP63
40benign mesothelioma10.0CDKN2A, MUC1
41anaplastic astrocytoma10.0CDKN2A, MKI67
42prostate cancer10.0MKI67, TP63
43leiomyosarcoma10.0MUC1, TP63
44breast fibroadenoma10.0MKI67, TP63
45tubular adenocarcinoma10.0MUC1, TP63
46adenosquamous carcinoma10.0TP63, MUC1
47pleomorphic adenoma10.0TP63, MUC1
48thymus cancer10.0TP63, MUC1
49neuroendocrine carcinoma10.0TP63, MUC1
50oxyphilic adenoma10.0MUC1, TP63

Graphical network of the top 20 diseases related to Ameloblastic Carcinoma:



Diseases related to ameloblastic carcinoma

Clinical Features for Ameloblastic Carcinoma

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Drugs & Therapeutics for Ameloblastic Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Ameloblastic Carcinoma

Drug clinical trials:

Search ClinicalTrials for Ameloblastic Carcinoma

Search NIH Clinical Center for Ameloblastic Carcinoma

Search CenterWatch for Ameloblastic Carcinoma

Genetic Tests for Ameloblastic Carcinoma

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Anatomical Context for Ameloblastic Carcinoma

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Animal Models for Ameloblastic Carcinoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Ameloblastic Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.9CDKN2A
2MP:00053799.6CDKN2A
3MP:00020068.0SDC1, TP63, CDKN2A, MUC1

Publications for Ameloblastic Carcinoma

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Genetic Variations for Ameloblastic Carcinoma

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Expression for genes affiliated with Ameloblastic Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ameloblastic Carcinoma

Search GEO for disease gene expression data for Ameloblastic Carcinoma.

Pathways for genes affiliated with Ameloblastic Carcinoma

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Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TP63, CDKN2A
2
Hide members
8.8TP63, CDKN2A, MKI67

Compounds for genes affiliated with Ameloblastic Carcinoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1mucicarmine449.8MUC1, TP63
2acetone449.8MUC1, MKI67
3b 723449.8TP63, MUC1
4p005449.6TP63, MKI67
5crcs449.6CDKN2A, MUC1
6p00001449.6MKI67, CDKN2A
7methanol44 2410.5CDKN2A, MKI67
8irinotecan44 49 1111.4MKI67, CDKN2A
9mitomycin c449.4MKI67, TP63
10silver449.4MKI67, CDKN2A
11mifepristone44 59 28 1112.4MUC1, MKI67
12steroid449.3CDKN2A, MKI67
13biotin44 11 2411.2CDKN2A, MUC1, MKI67
14folate449.2CDKN2A, MUC1, MKI67
15methotrexate44 49 1111.2MKI67, MUC1, CDKN2A
165fluorouracil449.2CDKN2A, MKI67, MUC1
17thymidine44 2410.1MUC1, MKI67, TP63
18purine44 2410.1CDKN2A, MUC1
19doxorubicin44 49 1111.0MKI67, CDKN2A, TP63
20hematoxylin448.7MKI67, MUC1, CDKN2A, TP63
21paraffin448.7TP63, CDKN2A, MUC1, MKI67
22cisplatin44 49 59 1111.7CDKN2A, TP63, MKI67, MUC1
23progesterone44 59 28 11 2412.7TP63, CDKN2A, MKI67, MUC1
24testosterone44 59 11 2411.7MKI67, MUC1, CDKN2A, TP63
25vegf448.7CDKN2A, MKI67, MUC1, TP63
26retinoic acid44 249.6MUC1, CDKN2A, MKI67, TP63

GO Terms for genes affiliated with Ameloblastic Carcinoma

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Sources:
16Gene Ontology
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Cellular components related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.5TP63, MUC1
2Golgi lumenGO:0057968.9SDC1, MUC1
3cytoplasmGO:0057377.4SDC1, TP63, CDKN2A, MUC1, MKI67

Biological processes related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5TP63, MUC1

Molecular functions related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020398.9TP63, CDKN2A, MUC1

Products for genes affiliated with Ameloblastic Carcinoma

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  • Antibodies
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  • Antibodies

Sources for Ameloblastic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet