MCID: AML004
MIFTS: 41

Ameloblastic Carcinoma malady

Rare diseases, Cancer diseases, Oral diseases categories
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Summaries for Ameloblastic Carcinoma

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NIH Rare Diseases:42 Ameloblastic carcinoma is a rare oral cancer that commonly develops towards the back of the lower or upper jaw. the cancer can develop spontaneously or arise from a preexisting ameloblastoma.  a common early symptom is swelling. the underlying cause of the cancer is not well understood.  last updated: 10/19/2011

MalaCards based summary: Ameloblastic Carcinoma is related to ameloblastoma and leukoplakia. An important gene associated with Ameloblastic Carcinoma is MKI67 (marker of proliferation Ki-67), and among its related pathways are TP53 network and Apoptosis. The compounds acetone and mifepristone have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle and lung, and related mouse phenotypes are taste/olfaction and vision/eye.

Aliases & Classifications for Ameloblastic Carcinoma

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 63UMLS via Orphanet
See all sources

Ameloblastic Carcinoma, Aliases & Descriptions:

Name: Ameloblastic Carcinoma 42 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Oral diseases


Characteristics (Orphanet epidemiological data):

48
ameloblastic carcinoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


External Ids:

UMLS via Orphanet63 C1314678

Related Diseases for Ameloblastic Carcinoma

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Diseases related to Ameloblastic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1ameloblastoma10.7
2leukoplakia10.4MKI67
3eccrine porocarcinoma10.4MUC1
4actinic keratosis10.3TP63
5malignant fibroxanthoma10.2MKI67, MUC1
6ependymoma10.2MUC1, MKI67
7synovial sarcoma10.2MKI67, MUC1
8cervical intraepithelial neoplasia10.2CDKN2A, MKI67
9lung cancer10.1MUC1, CDKN2A
10hypercalcemia10.1
11barrett's esophagus10.1MKI67, CDKN2A
12malignant peripheral nerve sheath tumor10.1CDKN2A, MUC1
13grade iii astrocytoma10.1CDKN2A, MKI67
14oligodendroglioma10.1MKI67, CDKN2A
15carcinoid syndrome10.1MUC1, MKI67
16bladder carcinoma10.1MKI67, CDKN2A
17oral leukoplakia10.1MKI67, TP63
18phyllode tumor10.1TP63, MKI67
19multiple myeloma10.1SDC1, CDKN2A
20malignant mesothelioma10.1CDKN2A, MUC1
21breast fibroadenoma10.1MKI67, TP63
22spindle cell carcinoma10.1MUC1, TP63
23thymus cancer10.1TP63, MUC1
24tubular adenocarcinoma10.0TP63, MUC1
25adenosquamous carcinoma10.0MUC1, TP63
26meningioma10.0MKI67, MUC1
27pleomorphic adenoma10.0TP63, MUC1
28papilloma10.0CDKN2A, TP63
29neuroendocrine carcinoma10.0TP63, MUC1
30oxyphilic adenoma10.0TP63, MUC1
31leiomyosarcoma10.0MUC1, TP63
32basal cell carcinoma10.0MKI67, TP63
33transitional cell carcinoma10.0MKI67, TP63
34stomach cancer9.9MKI67, MUC1, CDKN2A
35mucoepidermoid carcinoma9.9MKI67, TP63, MUC1
36salivary gland adenoid cystic carcinoma9.9MKI67, TP63, MUC1
37papillary carcinoma9.9MUC1, TP63, MKI67
38non-small cell lung carcinoma9.9CDKN2A, TP63
39burkitt's lymphoma9.9CDKN2A, MUC1, MKI67
40sarcoma9.9MUC1, TP63, MKI67
41cervical squamous cell carcinoma9.8CDKN2A, TP63, MKI67
42squamous cell carcinoma of the head and neck9.8CDKN2A, TP63
43laryngeal squamous cell carcinoma9.8CDKN2A, TP63, MKI67
44endometrial carcinoma9.8CDKN2A, MUC1, TP63
45lung adenocarcinoma9.8CDKN2A, MUC1, TP63
46lung small cell carcinoma9.8CDKN2A, MUC1, TP63
47breast cancer9.8MKI67, TP63, MUC1
48cervical cancer9.7CDKN2A, TP63
49adenoma9.6MKI67, TP63, MUC1, CDKN2A
50tongue squamous cell carcinoma9.6CDKN2A, MUC1, TP63, MKI67

Graphical network of the top 20 diseases related to Ameloblastic Carcinoma:



Diseases related to ameloblastic carcinoma

Symptoms for Ameloblastic Carcinoma

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Drugs & Therapeutics for Ameloblastic Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Ameloblastic Carcinoma

Search NIH Clinical Center for Ameloblastic Carcinoma

Genetic Tests for Ameloblastic Carcinoma

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Anatomical Context for Ameloblastic Carcinoma

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MalaCards organs/tissues related to Ameloblastic Carcinoma:

32
Smooth muscle, Lung

Animal Models for Ameloblastic Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Ameloblastic Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3MAPK8IP2, TP63
2MP:00053918.4CDKN2A, MAPK8IP2, MUC1, TP63
3MP:00020068.2SDC1, TP63, MUC1, CDKN2A
4MP:00107718.0CDKN2A, MUC1, TP63, SDC1
5MP:00053897.7SDC1, TP63, MAPK8IP2, CDKN2A
6MP:00053797.7CDKN2A, MAPK8IP2, MUC1, TP63, SDC1
7MP:00053767.5SDC1, TP63, MUC1, MAPK8IP2, CDKN2A

Publications for Ameloblastic Carcinoma

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Articles related to Ameloblastic Carcinoma:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Ameloblastic carcinoma: A clinicopathologic dilemma - Report of two cases with total review of literature from 1984 to 2012. (24987603)
2014
2
Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature. (25013517)
2014
3
Usefulness of (11)C-methionine positron emission tomography for detecting intracranial ameloblastic carcinoma: A case report. (25202358)
2014
4
A rare case of ameloblastic carcinoma. (25255357)
2014
5
Ameloblastic carcinoma: A case series. (25210376)
2014
6
Large ameloblastic carcinoma: A rare case with management. (24379872)
2013
7
Treatment strategy of a huge ameloblastic carcinoma. (23348302)
2013
8
The variability and complexity of ameloblastoma: carcinoma ex ameloblastoma or primary ameloblastic carcinoma. (22920533)
2013
9
Ameloblastic carcinoma, secondary type, of the mandible: a case report. (23099227)
2013
10
Ameloblastic carcinoma in a young patient. (24184061)
2013
11
Ameloblastic carcinoma of the mandible with clear cell changes: a case report. (23713037)
2013
12
Alpha smooth muscle actin expression in a case of ameloblastic carcinoma: a case report. (24422027)
2013
13
Ameloblastic carcinoma of the maxilla: A case report. (23205126)
2012
14
Ameloblastic carcinoma, primary type: case report, immunohistochemical analysis and literature review. (22493395)
2012
15
Ameloblastic carcinoma of maxilla. (23251064)
2012
16
Manifestation of an ameloblastic carcinoma ten years after follicular cyst enucleation in the mandibular ramus. (21741264)
2012
17
Ameloblastic carcinoma of the maxilla with extension into the ethmoidal air cells and close proximity to the anterior skull base: a rare case presentation. (23997861)
2012
18
Ameloblastic carcinoma: a case report with radiological features of computed tomography and magnetic resonance imaging and positron emission tomography. (21458329)
2011
19
Ameloblastic carcinoma: rare localization of a rare neoplasm. (22134276)
2011
20
Fine-needle aspiration biopsy of ameloblastic carcinoma of the mandible: a case report. (21915525)
2011
21
Carbon ion therapy for ameloblastic carcinoma. (21294917)
2011
22
Cytopathologic features of secondary peripheral ameloblastic carcinoma: a case report. (20607684)
2011
23
Ameloblastic carcinoma: Secondary dedifferentiated carcinoma of the mandible: Report of a rare entity with a brief review. (22529581)
2011
24
Ameloblastic carcinoma: a rare entity. (22701023)
2011
25
Ameloblastic carcinoma. (22190836)
2010
26
Ameloblastic carcinoma: a multicenter Nigerian study. (20538397)
2010
27
Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma. (19150605)
2009
28
New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. (19674470)
2009
29
Ameloblastic carcinoma: an analysis of 6 cases with review of the literature. (19800270)
2009
30
Maxillary ameloblastic carcinoma in a child. (16652346)
2008
31
Ameloblastic carcinoma of the maxilla: case report and review of the literature. (17942338)
2007
32
Ameloblastic carcinoma: an analysis of 14 cases. (17448710)
2007
33
Maxillary ameloblastic carcinoma in an Alaskan Malamute. (17197628)
2007
34
Ameloblastic carcinoma containing melanocyte and melanin pigment in the mandible: a case report and review of the literature. (16202083)
2005
35
Ameloblastic carcinoma: case report and literature review. (14653932)
2003
36
Spindle-cell ameloblastic carcinoma: A case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses. (12469140)
2003
37
Papilliferous keratoameloblastoma of mandible: a papillary ameloblastic carcinoma: report of a case with a 6-year follow-up and review of the literature. (12075410)
2002
38
Ameloblastic carcinoma. A case report with review of literature. (11987664)
2001
39
Ameloblastic carcinoma of the maxilla: a report of 3 cases. (9702634)
1998
40
Ameloblastic carcinoma of the maxilla. (7499939)
1995
41
Ameloblastic carcinoma: report of two cases. (1527663)
1992
42
Ameloblastic carcinoma: case report and review. (1725187)
1991
43
Ameloblastic carcinoma of the maxilla metastatic to the mandible. Case report. (2212021)
1990
44
Ameloblastic carcinoma. (2713320)
1989
45
Peripheral ameloblastic carcinoma: a case report of a rare neoplasm. (2716084)
1989
46
A case of ameloblastic carcinoma with pulmonary metastases. (3203092)
1988
47
Ameloblastic carcinoma: a clinicopathologic study and assessment of eight cases. (3313152)
1987
48
Ameloblastic carcinoma of the maxilla. A case report. (3467002)
1986
49
Basement membrane defect in ameloblastic carcinoma: a case study. (3459830)
1986
50
Malignant ameloblastoma or ameloblastic carcinoma. (6366686)
1984

Variations for Ameloblastic Carcinoma

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Expression for genes affiliated with Ameloblastic Carcinoma

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Expression patterns in normal tissues for genes affiliated with Ameloblastic Carcinoma

Search GEO for disease gene expression data for Ameloblastic Carcinoma.

Pathways for genes affiliated with Ameloblastic Carcinoma

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Pathways related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3CDKN2A, TP63
2
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.3CDKN2A, TP63
3
Show member pathways
8.9CDKN2A, TP63, MKI67

Compounds for genes affiliated with Ameloblastic Carcinoma

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Compounds related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1acetone4410.0MUC1, MKI67
2mifepristone44 28 61 1112.9MUC1, MKI67
3p00001449.9MKI67, CDKN2A
4methanol44 2410.9CDKN2A, MKI67
5silver449.9CDKN2A, MKI67
6irinotecan44 50 1111.9CDKN2A, MKI67
7crcs449.9MUC1, CDKN2A
8thymidylate449.8CDKN2A, MKI67
9purine44 2410.8CDKN2A, MUC1
10p005449.8TP63, MKI67
11vincristine44 50 1111.8MKI67, CDKN2A
12mucicarmine449.8TP63, MUC1
13b 723449.8TP63, MUC1
14mitomycin c449.7TP63, MKI67
15cytarabine44 50 1111.7CDKN2A, MUC1
16p003449.7MKI67, TP63
17adriamycin449.6MUC1, CDKN2A
18gold449.6CDKN2A, MUC1
19biotin44 24 1111.5MKI67, MUC1, CDKN2A
20carbohydrates449.5MKI67, MUC1
21bromodeoxyuridine449.5TP63, MKI67
22folate449.5CDKN2A, MUC1, MKI67
23agarose449.5MUC1, CDKN2A
24methotrexate50 44 1111.5CDKN2A, MUC1, MKI67
255fluorouracil449.5CDKN2A, MUC1, MKI67
26thymidine44 2410.3MKI67, TP63, MUC1
27nitric oxide44 24 1111.3CDKN2A, MUC1, MKI67
28formaldehyde44 2410.3MUC1, MKI67
29doxorubicin44 50 1111.3CDKN2A, TP63, MKI67
30threonine449.3MKI67, MUC1, CDKN2A
31steroid449.3MKI67, TP63, CDKN2A
32arginine449.2CDKN2A, TP63, MKI67
33oxygen44 2410.1CDKN2A, MUC1, MKI67
34hematoxylin448.9CDKN2A, MUC1, TP63, MKI67
35paraffin448.9MKI67, TP63, MUC1, CDKN2A
36cisplatin44 50 61 1111.9CDKN2A, MUC1, TP63, MKI67
37progesterone44 28 61 24 1112.9CDKN2A, MUC1, TP63, MKI67
38testosterone44 61 24 1111.9MKI67, TP63, MUC1, CDKN2A
39vegf448.9MKI67, TP63, MUC1, CDKN2A
40estrogen448.9CDKN2A, MUC1, TP63, MKI67
41retinoic acid44 249.9MKI67, TP63, MUC1, CDKN2A
42calcium44 50 24 1111.6CDKN2A, MUC1, TP63, MKI67

GO Terms for genes affiliated with Ameloblastic Carcinoma

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Cellular components related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.4MUC1, TP63
2Golgi lumenGO:0057968.9MUC1, SDC1
3cytoplasmGO:0057377.0CDKN2A, MKI67, SDC1, TP63, MUC1, MAPK8IP2

Biological processes related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4MUC1, TP63

Molecular functions related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080229.2SDC1, MKI67
2p53 bindingGO:0020398.8CDKN2A, MUC1, TP63
3protein bindingGO:0055156.8MKI67, SDC1, TP63, MUC1, MAPK8IP2, CDKN2A

Products for genes affiliated with Ameloblastic Carcinoma

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  • Antibodies
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Sources for Ameloblastic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet