MCID: AML004
MIFTS: 41

Ameloblastic Carcinoma malady

Rare diseases, Cancer diseases, Oral diseases categories
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Summaries for Ameloblastic Carcinoma

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Ameloblastic carcinoma is a rare oral cancer that commonly develops towards the back of the lower or upper jaw. the cancer can develop spontaneously or arise from a preexisting ameloblastoma.  a common early symptom is swelling. the underlying cause of the cancer is not well understood.  last updated: 10/19/2011

MalaCards: Ameloblastic Carcinoma is related to hypercalcemia and leukoplakia. An important gene associated with Ameloblastic Carcinoma is MKI67 (marker of proliferation Ki-67), and among its related pathways are TP53 network and Apoptosis. The compounds acetone and mifepristone have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle and lung, and related mouse phenotypes are taste/olfaction and vision/eye.

Aliases & Classifications for Ameloblastic Carcinoma

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Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Oral diseases


Characteristics (Orphanet epidemiological data):

49
ameloblastic carcinoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

ameloblastic carcinoma 43 49 62


External Ids:

UMLS via Orphanet63 C1314678

Related Diseases for Ameloblastic Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ameloblastic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1hypercalcemia10.1
2leukoplakia10.1MKI67
3eccrine porocarcinoma10.1MUC1
4actinic keratosis10.1TP63
5malignant fibroxanthoma10.0MKI67, MUC1
6ependymoma10.0MKI67, MUC1
7synovial sarcoma10.0MUC1, MKI67
8cervical intraepithelial neoplasia10.0MKI67, CDKN2A
9lung cancer10.0MUC1, CDKN2A
10barrett's esophagus10.0MKI67, CDKN2A
11malignant peripheral nerve sheath tumor10.0MUC1, CDKN2A
12anaplastic astrocytoma10.0MKI67, CDKN2A
13oligodendroglioma10.0CDKN2A, MKI67
14carcinoid syndrome10.0MKI67, MUC1
15bladder carcinoma10.0CDKN2A, MKI67
16oral leukoplakia10.0TP63, MKI67
17phyllode tumor10.0MKI67, TP63
18multiple myeloma10.0CDKN2A, SDC1
19benign mesothelioma10.0MUC1, CDKN2A
20breast fibroadenoma10.0MKI67, TP63
21spindle cell carcinoma10.0TP63, MUC1
22thymus cancer10.0MUC1, TP63
23tubular adenocarcinoma10.0TP63, MUC1
24adenosquamous carcinoma10.0TP63, MUC1
25meningioma10.0MUC1, MKI67
26pleomorphic adenoma10.0MUC1, TP63
27papilloma10.0CDKN2A, TP63
28oxyphilic adenoma10.0TP63, MUC1
29neuroendocrine carcinoma10.0MUC1, TP63
30leiomyosarcoma10.0MUC1, TP63
31basal cell carcinoma10.0MKI67, TP63
32transitional cell carcinoma10.0TP63, MKI67
33stomach cancer10.0CDKN2A, MUC1, MKI67
34mucoepidermoid carcinoma10.0MKI67, TP63, MUC1
35adenoid cystic carcinoma10.0MUC1, TP63, MKI67
36papillary carcinoma10.0MUC1, MKI67, TP63
37non-small cell lung carcinoma10.0TP63, CDKN2A
38burkitt's lymphoma10.0MKI67, MUC1, CDKN2A
39sarcoma10.0MUC1, MKI67, TP63
40cervical squamous cell carcinoma10.0MKI67, TP63, CDKN2A
41squamous cell carcinoma of the head and neck10.0CDKN2A, TP63
42laryngeal squamous cell carcinoma10.0MKI67, TP63, CDKN2A
43endometrial carcinoma10.0CDKN2A, TP63, MUC1
44malignant mesothelioma10.0MUC1, CDKN2A, TP63
45lung adenocarcinoma9.9CDKN2A, MUC1, TP63
46lung small cell carcinoma9.9TP63, MUC1, CDKN2A
47breast cancer9.9TP63, MKI67, MUC1
48cervical cancer9.9TP63, CDKN2A
49adenoma9.9CDKN2A, MUC1, TP63, MKI67
50tongue squamous cell carcinoma9.9CDKN2A, TP63, MKI67, MUC1

Graphical network of the top 20 diseases related to Ameloblastic Carcinoma:



Diseases related to ameloblastic carcinoma

Symptoms for Ameloblastic Carcinoma

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Drugs & Therapeutics for Ameloblastic Carcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Ameloblastic Carcinoma

Search NIH Clinical Center for Ameloblastic Carcinoma

Genetic Tests for Ameloblastic Carcinoma

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Anatomical Context for Ameloblastic Carcinoma

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Sources:
33MalaCards
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MalaCards organs/tissues related to Ameloblastic Carcinoma:

33
Smooth muscle, Lung

Animal Models for Ameloblastic Carcinoma or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Ameloblastic Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3MAPK8IP2, TP63
2MP:00053918.4CDKN2A, MAPK8IP2, MUC1, TP63
3MP:00020068.2SDC1, TP63, MUC1, CDKN2A
4MP:00107718.0CDKN2A, MUC1, TP63, SDC1
5MP:00053897.7SDC1, TP63, MAPK8IP2, CDKN2A
6MP:00053797.7CDKN2A, MAPK8IP2, MUC1, TP63, SDC1
7MP:00053767.5SDC1, TP63, MUC1, MAPK8IP2, CDKN2A

Publications for Ameloblastic Carcinoma

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Sources:
52PubMed
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Articles related to Ameloblastic Carcinoma:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Large ameloblastic carcinoma: A rare case with management. (24379872)
2013
2
Treatment strategy of a huge ameloblastic carcinoma. (23348302)
2013
3
The variability and complexity of ameloblastoma: carcinoma ex ameloblastoma or primary ameloblastic carcinoma. (22920533)
2013
4
Ameloblastic carcinoma, secondary type, of the mandible: a case report. (23099227)
2013
5
Ameloblastic carcinoma in a young patient. (24184061)
2013
6
Ameloblastic carcinoma of the mandible with clear cell changes: a case report. (23713037)
2013
7
Alpha smooth muscle actin expression in a case of ameloblastic carcinoma: a case report. (24422027)
2013
8
Ameloblastic carcinoma of the maxilla: A case report. (23205126)
2012
9
Ameloblastic carcinoma, primary type: case report, immunohistochemical analysis and literature review. (22493395)
2012
10
Ameloblastic carcinoma of maxilla. (23251064)
2012
11
Manifestation of an ameloblastic carcinoma ten years after follicular cyst enucleation in the mandibular ramus. (21741264)
2012
12
Comparative evaluation of expression of proliferating cell nuclear antigen in variants of ameloblastoma and ameloblastic carcinoma. (22842243)
2012
13
Ameloblastic carcinoma: a case report with radiological features of computed tomography and magnetic resonance imaging and positron emission tomography. (21458329)
2011
14
Ameloblastic carcinoma: rare localization of a rare neoplasm. (22134276)
2011
15
Fine-needle aspiration biopsy of ameloblastic carcinoma of the mandible: a case report. (21915525)
2011
16
Carbon ion therapy for ameloblastic carcinoma. (21294917)
2011
17
Cytopathologic features of secondary peripheral ameloblastic carcinoma: a case report. (20607684)
2011
18
Ameloblastic carcinoma: Secondary dedifferentiated carcinoma of the mandible: Report of a rare entity with a brief review. (22529581)
2011
19
Ameloblastic carcinoma: a rare entity. (22701023)
2011
20
Comparative immunohistochemical study of ameloblastoma and ameloblastic carcinoma. (22014999)
2011
21
Ameloblastic carcinoma. (22190836)
2010
22
Ameloblastic carcinoma: a multicenter Nigerian study. (20538397)
2010
23
Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma. (19150605)
2009
24
New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. (19674470)
2009
25
Ameloblastic carcinoma: an analysis of 6 cases with review of the literature. (19800270)
2009
26
Maxillary ameloblastic carcinoma in a child. (16652346)
2008
27
Ameloblastic carcinoma of the maxilla: case report and review of the literature. (17942338)
2007
28
Ameloblastic carcinoma: an analysis of 14 cases. (17448710)
2007
29
Maxillary ameloblastic carcinoma in an Alaskan Malamute. (17197628)
2007
30
Fine-needle aspiration cytology of pulmonary ameloblastic carcinoma of mandibular origin. (16470855)
2006
31
Ameloblastic carcinoma containing melanocyte and melanin pigment in the mandible: a case report and review of the literature. (16202083)
2005
32
Expression profiling of ameloblastic carcinoma. (15167247)
2004
33
Ameloblastic carcinoma: case report and literature review. (14653932)
2003
34
Spindle-cell ameloblastic carcinoma: A case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses. (12469140)
2003
35
Papilliferous keratoameloblastoma of mandible: a papillary ameloblastic carcinoma: report of a case with a 6-year follow-up and review of the literature. (12075410)
2002
36
Ameloblastic carcinoma. A case report with review of literature. (11987664)
2001
37
Ameloblastic carcinoma of the maxilla: a report of 3 cases. (9702634)
1998
38
Fine-needle aspiration cytology of ameloblastic carcinoma of the maxilla: a rare tumor. (8732656)
1996
39
Ameloblastic carcinoma of the maxilla. (7499939)
1995
40
DNA ploidy of ameloblastoma and ameloblastic carcinoma of the jaws. Analysis by image and flow cytometry. (8239934)
1993
41
Ameloblastic carcinoma: report of two cases. (1527663)
1992
42
Ameloblastic carcinoma: case report and review. (1725187)
1991
43
Ameloblastic carcinoma of the maxilla metastatic to the mandible. Case report. (2212021)
1990
44
Ameloblastic carcinoma. (2713320)
1989
45
Peripheral ameloblastic carcinoma: a case report of a rare neoplasm. (2716084)
1989
46
A case of ameloblastic carcinoma with pulmonary metastases. (3203092)
1988
47
Ameloblastic carcinoma: a clinicopathologic study and assessment of eight cases. (3313152)
1987
48
Ameloblastic carcinoma of the maxilla. A case report. (3467002)
1986
49
Basement membrane defect in ameloblastic carcinoma: a case study. (3459830)
1986
50
Malignant ameloblastoma or ameloblastic carcinoma. (6366686)
1984

Variations for Ameloblastic Carcinoma

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Expression for genes affiliated with Ameloblastic Carcinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ameloblastic Carcinoma

Search GEO for disease gene expression data for Ameloblastic Carcinoma.

Pathways for genes affiliated with Ameloblastic Carcinoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology
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Pathways related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3CDKN2A, TP63
2
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.3CDKN2A, TP63
3
Show member pathways
8.9CDKN2A, TP63, MKI67

Compounds for genes affiliated with Ameloblastic Carcinoma

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 24HMDB, 51PharmGKB
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Compounds related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1acetone4510.0MUC1, MKI67
2mifepristone45 29 61 1112.9MUC1, MKI67
3p00001459.9MKI67, CDKN2A
4methanol45 2410.9CDKN2A, MKI67
5silver459.9CDKN2A, MKI67
6irinotecan45 51 1111.9CDKN2A, MKI67
7crcs459.9MUC1, CDKN2A
8thymidylate459.8CDKN2A, MKI67
9purine45 2410.8CDKN2A, MUC1
10p005459.8TP63, MKI67
11vincristine45 51 1111.8MKI67, CDKN2A
12mucicarmine459.8TP63, MUC1
13b 723459.8TP63, MUC1
14mitomycin c459.7TP63, MKI67
15cytarabine45 51 1111.7CDKN2A, MUC1
16p003459.7MKI67, TP63
17adriamycin459.6MUC1, CDKN2A
18gold459.6CDKN2A, MUC1
19biotin45 24 1111.5MKI67, MUC1, CDKN2A
20carbohydrates459.5MKI67, MUC1
21bromodeoxyuridine459.5TP63, MKI67
22folate459.5CDKN2A, MUC1, MKI67
23agarose459.5MUC1, CDKN2A
24methotrexate51 45 1111.5CDKN2A, MUC1, MKI67
255fluorouracil459.5CDKN2A, MUC1, MKI67
26thymidine45 2410.3MKI67, TP63, MUC1
27nitric oxide45 24 1111.3CDKN2A, MUC1, MKI67
28formaldehyde45 2410.3MUC1, MKI67
29doxorubicin45 51 1111.3CDKN2A, TP63, MKI67
30threonine459.3MKI67, MUC1, CDKN2A
31steroid459.3MKI67, TP63, CDKN2A
32arginine459.2CDKN2A, TP63, MKI67
33oxygen45 2410.1CDKN2A, MUC1, MKI67
34hematoxylin458.9CDKN2A, MUC1, TP63, MKI67
35paraffin458.9MKI67, TP63, MUC1, CDKN2A
36cisplatin45 51 61 1111.9CDKN2A, MUC1, TP63, MKI67
37progesterone45 29 61 24 1112.9CDKN2A, MUC1, TP63, MKI67
38testosterone45 61 24 1111.9MKI67, TP63, MUC1, CDKN2A
39vegf458.9MKI67, TP63, MUC1, CDKN2A
40estrogen458.9CDKN2A, MUC1, TP63, MKI67
41retinoic acid45 249.9MKI67, TP63, MUC1, CDKN2A
42calcium45 51 24 1111.6CDKN2A, MUC1, TP63, MKI67

GO Terms for genes affiliated with Ameloblastic Carcinoma

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Sources:
16Gene Ontology
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Cellular components related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.4MUC1, TP63
2Golgi lumenGO:0057968.9MUC1, SDC1
3cytoplasmGO:0057377.0CDKN2A, MKI67, SDC1, TP63, MUC1, MAPK8IP2

Biological processes related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4MUC1, TP63

Molecular functions related to Ameloblastic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080229.2SDC1, MKI67
2p53 bindingGO:0020398.8CDKN2A, MUC1, TP63
3protein bindingGO:0055156.8MKI67, SDC1, TP63, MUC1, MAPK8IP2, CDKN2A

Products for genes affiliated with Ameloblastic Carcinoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Ameloblastic Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet