Amenorrhea malady

Wikipedia: Amenorrhoea (BE), amenorrhea (AmE), or amenorrhœa, is the absence of a menstrual period in a woman of...⁴⁴ more...

MalaCards: Amenorrhea, also known as amenorrhea nos (finding), is related to eating disorder and sertoli-leydig cell tumor. An important gene associated with Amenorrhea is POF1B (premature ovarian failure, 1B), and among its related pathways are Development_Role of Activin A in cell differentiation and proliferation and Development Role of Activin A in cell differentiation and proliferation. The drugs hydroxyprogesterone and medroxyprogesterone acetate and the compounds glucose and 25-hydroxyvitamin d have been mentioned in the context of this disorder. Affiliated tissues include cortex, thyroid and ovary, and related mouse phenotypes are hematopoietic system and integument.

Aliases & Descriptions:

amenorrhea 6 8 43 amenorrhea nos (finding) 6 absence of menstruation 6 amenorrhea (finding) 6

amenorrhoea nos 6 amenorrhoea 6 amenia 6

Diseases related to amenorrhea by text searches and GeneDecks gene sharing:

(show top 50)    (show all 528)

id	Related Disease	Score	Top Affiliating Genes
1	eating disorder	28.9	LEP, GHRL, PYY, CRH, LSL, NPY
2	sertoli-leydig cell tumor	28.9	FSHR, ALPP, CYP17A1, CYP19A1, SRY, NR5A1
3	premature ovarian failure	28.7	BMP15, LGR6, FSHR, FOXL2, FMR1, IGFBP3
4	complete androgen insensitivity syndrome	28.2	CGA, AR, CYP19A1
5	androgen insensitivity syndrome	28.2	AR, CYP19A1
6	gonadoblastoma	27.8	FOXL2, ALPP, SRY, WT1, SLC25A10
7	gonadal dysgenesis	27.2	BRD2, BMP15, BGLAP, FSHR, GNRH1, SRY
8	mayer-rokitansky-kuster-hauser syndrome	26.9	FSHR, FOXL2, FMR1, APOB, GHR, CYP17A1
9	leydig cell tumor	26.7	BRD2, LHCGR, CGA, FSHR, INSR, ALPP
10	sleep disorder	25.9	LEP, INS, LSL, PRL, NPPB, NPY
11	delayed puberty	25.5	LHCGR, LEP, CGA, FSHB, FSHR, IGFBP3
12	acanthosis nigricans	24.7	LEP, INS, INSR, IGF1, GH1, SHBG
13	acne	23.8	BGLAP, LEP, AR, INS, IGFBP3, IGF1
14	diabetes insipidus	23.5	CGA, INS, IGF1, GNRH1, CALCA, TRH
15	polycystic ovary syndrome	23.5	LHCGR, LEP, CGA, FSHR, AR, INS
16	was-related disorders	23.4	LEP, FMR1, INS, APOA1, APOB, IGF1
17	multiple sclerosis	23.0	LEP, FOXO3, INS, APOA1, APOB, IGFBP3
18	hyperprolactinemia	22.9	BRD2, BGLAP, CGA, INS, IGFBP3, IGF1
19	short stature	22.2	BGLAP, LEP, FMR1, AR, INS, IGFBP3
20	anorexia nervosa	21.5	BGLAP, LEP, INS, INSR, IGFBP3, IGF1
21	infertility	20.4	BRD2, BMP15, LHB, LHCGR, LGR6, LEP
22	hyperandrogenism	20.4	BRD2, LHCGR, LEP, CGA, FSHR, AR
23	blindness	19.7	BGLAP, LEP, CGA, FSHB, AR, INS
24	hypogonadism	19.0	BRD2, BGLAP, LHB, LHCGR, LGR6, LEP
25	rheumatoid arthritis	18.5	BRD2, BGLAP, LEP, FOXO3, AR, INS
26	arthritis	18.3	BRD2, BGLAP, LEP, FOXO3, AR, INS
27	insulin resistance	16.9	BGLAP, LEP, CGA, CD3E, FOXO3, AR
28	breast cancer	15.7	BRD2, BMP15, BGLAP, LHCGR, LEP, CGA
29	thyroiditis	15.7	BGLAP, LHCGR, LGR6, LEP, CGA, FSHB
30	precocious puberty, male	13.9	LHCGR, FSHR, CYP19A1
31	ovarian dysgenesis	13.8	BMP15, LHCGR, FSHR, PSMC3IP
32	46,xy disorder of sex development and 46,xy complete gonadal dysgenesis	13.8	SRY, NR5A1, WNT4
33	leydig cell adenoma	13.8	LHCGR, CGA, GNRH1
34	premature ejaculation	13.7	LEP, CYP19A1, LSL, PRL
35	androgen insensitivity syndrome, partial	13.7	AR, CYP19A1, SHBG
36	male breast cancer	13.7	AR, CYP17A1, CYP19A1, SHFM1, PRL
37	primary ciliary dyskinesia	13.7	BMP15, CGA, CYP19A1
38	anorchia	13.7	CGA, SRY, NR5A1
39	swyer syndrome	13.7	SRY, NR5A1, SHBG
40	adrenal carcinoma	13.7	LEP, CYP17A1, CRH
41	testotoxicosis	13.7	LHCGR, CYP19A1
42	testicular disease	13.7	BRD2, GNRH1, SHBG, PRL
43	penis paget's disease	13.7	BRD2, SHBG, PRL
44	bulimia nervosa	13.7	LEP, PYY, LSL
45	androgenetic alopecia	13.7	AR, CYP19A1, SHBG
46	y chromosome infertility	13.7	CGA, FSHB, FSHR, AR, GNRH1, PRL
47	ovarian cyst	13.6	CGA, GNRH1, CYP19A1
48	nutritional deficiency disease	13.6	LEP, GHRL, TTR
49	sexual disorder	13.6	BRD2, SHBG, PRL
50	46, xy disorders of sex development	13.6	AR, SRY, NR5A1, WT1, WNT4

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bromocriptine, bromocriptine mesylate, gonadorelin, gonadorelin acetate, gonadorelin hydrochloride, hydroxyprogesterone, hydroxyprogesterone caproate, medroxyprogesterone, medroxyprogesterone acetate, norelgestromin, norethynodrel, norgestimate, progesterone, progesterone pwdr [va product]

MalaCards organs/tissues related to amenorrhea:

²²

MGI Mouse Phenotypes related to amenorrhea:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.1	WNT4, FOXO3, CD3E, FSHR
2	integument phenotype	MP:0010771	8.4	OXT, PRL, POMC, WNT4, GAL, PLOD1
3	endocrine/exocrine gland phenotype	MP:0005379	8.3	LHCGR, WT1, PSMC3IP, WNT4, AFP, GAL
4	liver/biliary system phenotype	MP:0005370	8.1	GHR, CYP19A1, PRL, POR, GH1, APOB
5	reproductive system phenotype	MP:0005389	7.9	BMP15, LHB, LHCGR, LEP, CGA, FSHB
6	mortality/aging	MP:0010768	7.7	CYP17A1, SRY, NR5A1, PLOD1, OXT, POR
7	immune system phenotype	MP:0005387	7.6	CRH, WT1, PRL, POMC, WNT4, ADIPOQ
8	normal phenotype	MP:0002873	7.1	CYP19A1, NR5A1, CRH, WT1, POF1B, NPY
9	growth/size phenotype	MP:0005378	6.3	NR5A1, CYP19A1, PYY, TNFRSF11B, TRH, CRH
10	homeostasis/metabolism phenotype	MP:0005376	INF	BRD2, , APOA1, APOB, IGFBP3, IGF1
11	nervous system phenotype	MP:0003631	INF	CYP19A1, NR5A1, CRH, PRL, POR, POMC
12	cellular phenotype	MP:0005384	INF	GNRH1, TNFRSF11B, CYP19A1, NR5A1, CRH, WT1
13	behavior/neurological phenotype	MP:0005386	INF	CYP19A1, NR5A1, PLOD1, OXT, PRL, POR
14	adipose tissue phenotype	MP:0005375	INF	GHR, GHRL, PYY, CYP19A1, POMC, NPY
15	renal/urinary system phenotype	MP:0005367	INF	WT1, OXT, POR, NPPA, WNT4, GHR
16	cardiovascular system phenotype	MP:0005385	INF	CYP19A1, NR5A1, PLOD1, WT1, OXT, POR

Articles related to amenorrhea:

(show top 50)    (show all 81)

id	Title	Authors	Year	Affiliating Genes
1	Effects of oral contraceptives on natriuretic peptide levels in women with hypothalamic amenorrhea: a pilot study. (21620395)	Lin E.... Miller K.K.	2011	NPPB
2	Follicle stimulating hormone receptor gene variants i n women with primary and secondary amenorrhea. (20237833)	Achrekar S.K.... Mahale S.D.	2010	FSHR
3	A new FSHbeta mutation in a 29-year-old woman with pr imary amenorrhea and isolated FSH deficiency: functional characterization and o varian response to human recombinant FSH. (19966036)	Kottler M.L.... Young J.	2010	FSHB
4	Steroidogenic factor-1 (SF-1) gene mutation as a freq uent cause of primary amenorrhea in 46,XY female adolescents with low testoster one concentration. (20302644)	Philibert P.... Sultan C.	2010	NR5A1, WT1, SRY
5	Elevated PYY is associated with energy deficiency and indices of subclinical disordered eating in exercising women with hypothalamic amenorrhea. (18929607)	Scheid J.L.... De Souza M.J.	2009	PYY
6	Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. (19129711)	Arnhold I.J.... Latronico A.C.	2009	LHCGR, LHB
7	Peptide YY in adolescent athletes with amenorrhea, eu menorrheic athletes and non-athletic controls. (19344792)	Russell M.... Misra M.	2009	LEP, ADIPOQ, GHRL
8	Functional hypothalamic amenorrhea: current view on neuroendocrine aberrations. (18224538)	Meczekalski B.... Genazzani A.R.	2008	NPY, CRH
9	Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea. (17959613)	Gallardo T.D.... Castrillon D.H.	2008	FOXO3
10	Acylated ghrelin and leptin in adolescent athletes with amenorrhea, eumenorrheic athletes and controls: a cross-sectional study. (18331605)	Christo K.... Misra M.	2008	LEP, GHRL
11	Elevated ghrelin level in women of normal weight with amenorrhea is related to disordered eating. (18001718)	Schneider L.F.... Warren M.P.	2008	GHRL
12	A novel mutation in exon8 of the follicle-stimulating hormone receptor in a woman with primary amenorrhea. (19172541)	Nakamura Y.... Sugino N.	2008	FSHR
13	LH/FSH ratio: a better marker of secondary amenorrhea in patients from eastern Nepal. (18092428)	Lamsal M.... Sridhar M.G.	2007	PRL
14	Functional hypothalamic amenorrhea is associated with elevated ghrelin and disordered eating. (17074331)	Schneider L.F.... Warren M.P.	2006	GHRL
15	Amenorrhea after weight recover in anorexia nervosa: role of body composition and endocrine abnormalities. (16801735)	Jacoangeli F.... Bollea M.R.	2006	PRL
16	Resumption of menses with initiation of letrozole aft er five years of amenorrhea on tamoxifen: caution needed when using tamoxifen f ollowed by aromatase inhibitors. (16537187)	Hargis J.B.... Nakajima S.T.	2006	CYP19A1
17	Effects of an oral contraceptive (norgestimate/ethinyl estradiol) on bone mineral density in women with hypothalamic amenorrhea and osteopenia: an open-label extension of a double-blind, placebo-controlled study. (16102557)	Warren M.P.... Friedman A.J.	2005	BGLAP
18	Serum leptin and lactational amenorrhea in well-nourished and undernourished lactating women. (15820811)	Tennekoon K.H.... Karunanayake E.H.	2005	LEP
19	Recombinant human leptin in women with hypothalamic amenorrhea. (15342807)	Welt C.K.... Mantzoros C.S.	2004	IGFBP3, POMC, LEP
20	Effects of a triphasic combination oral contraceptive containing norgestimate/ethinyl estradiol on biochemical markers of bone metabolism in young women with osteopenia secondary to hypothalamic amenorrhea. (12915650)	Grinspoon S.K.... Warren M.P.	2003	TNFRSF11B
21	Bone turnover markers during lactation, postpartum amenorrhea and resumption of menses. (12730783)	Holmberg-Marttila D.... SievAonen H.	2003	BGLAP
22	Molecular breakpoint analysis and relevance of variable mosaicism in a woman with short stature, primary amenorrhea, unilateral gonadoblastoma, and a 46,X,del(Y)(q11)/45,X karyotype. (12239720)	Kotzot D.... Froster U.G.	2002	SRY
23	Exercise-associated amenorrhea: are altered leptin le vels an early warning sign? (20086494)	Warren M.P.... Bronson E.M.	2002	LEP
24	Effects of cyproheptadine clorhydrate, a serotonin receptor antagonist, on endocrine parameters in weight-loss related amenorrhea. (11560101)	Genazzani A.D.... Petraglia F.	2001	IGF1
25	Increased adrenal steroid secretion in response to CRF in women with hypothalamic amenorrhea. (11595505)	Genazzani A.D.... Genazzani A.R.	2001	CRH
26	A longitudinal study of disturbances of the hypothalamic-pituitary-adrenal axis in women with progestin-negative functional hypothalamic amenorrhea. (11591409)	Kondoh Y.... Hirahara F.	2001	CRH
27	Hypothalamic amenorrhea with normal body weight: ACTH, allopregnanolone and cortisol responses to corticotropin-releasing hormone test. (10700723)	Meczekalski B.... Genazzani A.R.	2000	CRH
28	The evaluation of galanin, gonadotropin and estradiol levels in girls with simple weight loss due to amenorrhea (10462976)	Meczekalski B.... Halerz-Nowakowska B.	1999	NPY, GAL
29	Functional hypothalamic amenorrhea: hypoleptinemia and disordered eating. (10084564)	Warren M.P.... Ramos R.H.	1999	LEP
30	Assessment of hypothalamic-pituitary function by hormonal pulsatility, gonadotropin-releasing hormone and thyrotropin-releasing hormone testing in women with euprolactinemic secondary amenorrhea. (9838765)	Lin K.C.... Jong S.B.	1998	PRL, GNRH1, TRH
31	Nutritional and endocrine-metabolic aberrations in women with functional hypothalamic amenorrhea. (9435412)	Laughlin G.A.... Yen S.S.	1998	GHR
32	Characterization of pulsatile secretion of gonadotropin and prolactin in women with normal menstrual cycle, secondary amenorrhea and polycystic ovary syndrome (PCOS). (9542361)	Lin K.C.... Lee J.N.	1998	PRL
33	Treatment of hyperprolactinemic amenorrhea with cabe rgoline (9674185)	Fideleff H.L.... Sinai I.	1997	PRL
34	Lower bone density (osteopenia) in adolescent girls with oligomenorrhea and secondary amenorrhea (9411343)	Csermely T.... SzabA^ I.	1997	PRL
35	Leptin in anorexia nervosa and amenorrhea. (9246658)	Licinio J.	1997	LEP
36	Disorder of 17 beta-hydroxysteroid dehydrogenase as the cause of hypergonadotropic hypogonadism in 2 siblings with primary amenorrhea (8991848)	Wieacker P.... Muhlendahl K.E.	1996	HSD17B13
37	An inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46,XX female. (8923827)	Toledo S.P.... Kremer H Themmen A.P.	1996	CGA
38	Nocturnal melatonin and luteinizing hormone rhythms in women with hyperprolactinemic amenorrhea. (8815190)	Luboshitzky R.... Lavie P.	1996	PRL
39	Cortisol levels alter the response to metoclopramide in patients with hypothalamic amenorrhea. (7793305)	Mendes M.C.... Silva de SA! M.F.	1995	GNRH1
40	Hyperprolactinemic amenorrhea:treatment with cabergo line versus bromocriptine. Results of a national multicenter randomized double- blind study (7784413)	Pascal-Vigneron V.... Leclere J.	1995	PRL
41	Evaluation of beta-endorphin levels and gonadotropin, prolactin, cortisol and estradiol in serum of girls with secondary amenorrhea associated with weight loss (8682346)	Meczekalski B.... Warenik-Szymankiewicz A.	1995	PRL
42	Amenorrhea in anorexia nervosa. Neuroendocrine control of hypothalamic dysfunction. (7920581)	Golden N.H.... Shenker I.R.	1994	PRL
43	Menstrual-associated sleep disorder: an unusual hyper somniac variant associated with both menstruation and amenorrhea with a possibl e link to prolactin and metoclopramide. (8378689)	Bamford C.R.	1993	PRL
44	Lactational amenorrhea. (8449188)	McNeilly A.S.	1993	PRL
45	Sertoli-Leydig cell tumor of the ovary: a rare cause of amenorrhea. (1565381)	Larsen W.G.... Frieder R.	1992	AFP
46	Ten-year follow-up of patients with secondary amenorrhea and normal prolactin. (2048615)	Davajan V.... Anderson D.J.	1991	PRL
47	The role of endogenous opiates in athletic amenorrhea . (1900478)	Samuels M.H.... Robbins R.	1991	PRL
48	Hypothalamo-hypophyseal amenorrhea. I. The clinical and laboratory manifestations (2127582)	Espinosa de los Monteros Mena A.... Karchmer S.	1990	PRL
49	The effect of peroral lynestrenol on serum lipids and lipoproteins in therapeutic amenorrhea of mentally retarded women. (2346078)	Huovinen K.... Vesterinen H.	1990	APOA1, APOB
50	The efficacy of lisuride in the treatment of hyperpro lactinemic amenorrhea. (2351912)	Rojanasakul A.... Chailurkit L.O.	1990	PRL

Genes related to amenorrhea according to GeneCards:

(show top 50)    (show all 65)

id	Symbol	Description	Score	GeneCards Section Context
1	POF1B	premature ovarian failure, 1B	11.0	Summaries
2	POR	P450 (cytochrome) oxidoreductase	11.0	Summaries
3	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
4	FSHR	follicle stimulating hormone receptor	11.0	Publications
5	PRL	prolactin	11.0	Publications
6	FSHB	follicle stimulating hormone, beta polypeptide	11.0	Publications
7	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.0	Publications
8	SRY	sex determining region Y	11.0	Publications
9	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0	Publications
10	LGR6	leucine-rich repeat containing G protein-coupled receptor 6	11.0
11	LEP	leptin	11.0	Publications
12	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0
13	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
14	AR	androgen receptor	11.0
15	RFPL4A	ret finger protein-like 4A	11.0
16	NOBOX	NOBOX oogenesis homeobox	11.0	Publications
17	BMP15	bone morphogenetic protein 15	11.0
18	LHB	luteinizing hormone beta polypeptide	11.0	Publications
19	FIGLA	folliculogenesis specific basic helix-loop-helix	11.0
20	PSMC3IP	PSMC3 interacting protein	11.0
21	FOXL2	forkhead box L2	11.0
22	GBP4	guanylate binding protein 4	11.0
23	HSD17B1	hydroxysteroid (17-beta) dehydrogenase 1	11.0
24	FAM105A	family with sequence similarity 105, member A	11.0	Disorders
25	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	11.0	Publications
26	WNT4	wingless-type MMTV integration site family, member 4	11.0	Publications
27	BAZ2A	bromodomain adjacent to zinc finger domain, 2A	11.0
28	SHFM1	split hand/foot malformation (ectrodactyly) type 1	11.0
29	SLC25A10	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	11.0
30	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	11.0
31	PYY	peptide YY	11.0	Publications
32	CRH	corticotropin releasing hormone	11.0	Publications
33	SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	11.0
34	TRH	thyrotropin-releasing hormone	11.0	Publications
35	FMR1	fragile X mental retardation 1	11.0
36	FOXO3	forkhead box O3	11.0	Publications
37	GAL	galanin prepropeptide	11.0	Publications
38	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
39	NPY	neuropeptide Y	11.0	Publications
40	SHBG	sex hormone-binding globulin	11.0	Publications
41	PLOD1	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	11.0
42	LSL	Leptin, serum levels of	11.0	Publications
43	FER1L6	fer-1-like 6 (C. elegans)	11.0
44	BRD2	bromodomain containing 2	11.0
45	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
46	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
47	ALPP	alkaline phosphatase, placental	11.0	Publications
48	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
49	AFP	alpha-fetoprotein	11.0	Publications
50	TTR	transthyretin	11.0	Publications

Pathways related to amenorrhea according to GeneDecks:

(show all 14)

id	Pathway	Score	Top Affiliating Genes
1	Development_Role of Activin A in cell differentiation and proliferation41	10.3	NR5A1, FSHR, FSHB, CGA, LHCGR, LHB
2	Development Role of Activin A in cell differentiation and proliferation10	10.3	NR5A1, FSHR, FSHB, CGA, LHCGR, LHB
3	Estrogen Metabolism Pathway34	10.2	CYP19A1, SULT2A1, HSD17B1
4	G alpha (s) signalling events38	9.9	POMC, FSHB, CGA, LHB
5	Neuroactive ligand-receptor interaction20	9.2	PRL, GHR, GH1, FSHR, FSHB, CGA
6	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.7	BGLAP, CYP19A1, TNFRSF11B, CALCA, IGF1, AR
7	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.7	CYP19A1, TNFRSF11B, CALCA, IGF1, AR, CGA
8	Selected targets of GCR-alpha10	INF	GHR, , INS, FSHB, CGA, LEP
9	eIF2 Pathway36	INF	GH1, GNRH1, IGF1, , INS, LHB
10	Transcription Receptor-mediated HIF regulation10	INF	IGF1, IGFBP3, , INS
11	JAK-STAT Pathway36	INF	PRL, GHR, GH1, GNRH1, IGF1,
12	mTOR Pathway36	INF	GH1, GNRH1, IGF1, , INS, LHB
13	Transcription_Receptor-mediated HIF regulation41	INF	IGF1, IGFBP3, , INS
14	Nanog in Mammalian ESC Pluripotency36	INF	LHB, , IGF1, GNRH1, GH1, WNT4

Compounds related to amenorrhea according to GeneDecks:

(show top 50)    (show all 361)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.7	TRH
2	25-hydroxyvitamin d32	9.9	ADIPOQ, TNFRSF11B, ALPP, LEP, BGLAP
3	bromocriptine32 9 9	11.8	GAL, POMC, PRL, TRH, GH1, GNRH1
4	17-hydroxyprogesterone32 18	10.5	ADIPOQ, POMC, POR, PRL, SHBG, CRH
5	pge232	9.1	ADIPOQ, NPPB, OXT, CRH, NR5A1, CYP19A1
6	naloxone32 34 9 9	12.1	GAL, POMC, PRL, OXT, CRH, TRH
7	tibolone32	9.0	LSL, SHBG, CYP19A1, CALCA, HSD17B13, GNRH1
8	ascorbic acid32 18	9.6	AR, CGA, BGLAP, IGFBP3, ALPP, HSD17B13
9	nifedipine32 9 9	10.5	GHRL, GH1, GNRH1, ALPP, APOA1, LEP
10	leuprolide acetate32	8.5	FSHB, CGA, LHCGR, IGF1, GNRH1, GH1
11	buserelin32 9 9	10.5	LHCGR, PRL, OXT, CYP19A1, CALCA, GNRH1
12	oxandrolone32 9 9	10.3	TTR, SHBG, GHRL, GH1, IGF1, IGFBP3
13	aspartate32	8.1	POMC, LHCGR, OXT, SHBG, PLOD1, CRH
14	acipimox32	8.0	LEP, INS, APOA1, APOB, ADIPOQ, LSL
15	deoxypyridinoline32	7.8	CALCA, ALPP, IGF1, IGFBP3, BGLAP, GH1
16	estradiol32 9 18 9	10.8	AFP, POMC, PRL, OXT, SHBG, CRH
17	hexarelin32	7.7	PRL, OXT, CRH, GHRL, GHR, GH1
18	progesterone32 42 9 18 9	11.5	GNRH1, AR, FSHR, FSHB, CGA, LHCGR
19	estrone32 9 18 9	10.3	GH1, HSD17B13, HSD17B1, GNRH1, IGF1, IGFBP3
20	ribonucleic acid32	7.2	FSHR, FSHB, CGA, LHCGR, IGFBP3, POMC
21	forskolin32 42 9 9	10.1	GHRL, GH1, CALCA, FMR1, CGA, LHCGR
22	adenylate32	6.9	FSHR, FSHB, CGA, LGR6, LHCGR, AR
23	triiodothyronine32	6.7	LSL, SHBG, SULT2A1, TNFRSF11B, TRH, GHRL
24	dhea32	6.7	GAL, ADIPOQ, IGF1, IGFBP3, INS, AR
25	clonidine32 9 9	8.5	GAL, BGLAP, LEP, CGA, NPY, POMC
26	dehydroepiandrosterone sulfate32	6.2	GHR, GH1, HSD17B13, GNRH1, IGF1, IGFBP3
27	gnrh32	6.0	GAL, NPY, POMC, LSL, SHBG, CRH
28	tamoxifen32 34 9 9	9.0	PRL, LSL, SHBG, CYP19A1, CYP17A1, SULT2A1
29	lactate32	6.0	CALCA, HSD17B13, GNRH1, ALPP, IGFBP3, APOB
30	norepinephrine32 9 18 9	8.9	SHBG, LEP, CRH, PYY, TRH, GHRL
31	androstenedione32 18	6.7	LEP, CYP19A1, CYP17A1, GHR, GH1, HSD17B13
32	cholesterol32 9 18 9	8.6	HSD17B13, ALPP, IGF1, IGFBP3, APOB, APOA1
33	acth32	5.1	NPPA, POMC, PRL, OXT, LSL, SHBG
34	creatinine32	4.9	LEP, CRH, TNFRSF11B, GHRL, GHR, GH1
35	testosterone32 9 18 9	INF	WNT4, NPPB, POR, PRL, OXT, TTR
36	dihydrotestosterone32 9 18 9	INF	ADIPOQ, , AR, CGA, LEP, BGLAP
37	thyroxine32 18	INF	AFP, ADIPOQ, CALCA, GNRH1, ALPP, IGF1
38	progestin32	INF	PRL, OXT, SHBG, CYP19A1, CYP17A1, HSD17B13
39	dexamethasone32 42 34 9 9	INF	GAL, AFP, ADIPOQ, NPPB, POMC, POR
40	serine32	INF	WT1, PLOD1, CRH, NR5A1, SRY, CYP17A1
41	arginine32	INF	POR, PRL, OXT, TTR, LSL, SHBG
42	vitamin d32	INF	CALCA, ALPP, IGF1, IGFBP3, , AR
43	epinephrine32 9 18 9	INF	GAL, AFP, NPY, NPPB, NPPA, POMC
44	dopamine32 9 18 9	INF	GAL, ADIPOQ, NPPA, OXT, CRH, SULT2A1
45	alanine32	INF	FOXO3, FOXL2, FSHR, CGA, LHCGR, BGLAP
46	metformin32 34 9 9	INF	ADIPOQ, POMC, LSL, SHBG, CYP19A1, CYP17A1
47	c-peptide32	INF	GAL, ADIPOQ, LSL, SHBG, GHRL, GHR
48	clomiphene citrate32	INF	AFP, PRL, SHBG, CRH, CYP19A1, GH1
49	estrogen32	INF	NPPA, POMC, POR, PRL, OXT, TTR
50	glutamate32	INF	AR, FMR1, LEP, LHCGR, INS,

Cellular components related to amenorrhea according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	8.6	POMC, OXT, TRH, GHRL, APOA1, INS
2	extracellular space	GO:005615	3.7	AFP, GNRH1, IGF1, IGFBP3, APOB, APOA1
3	extracellular region	GO:005576	2.8	GAL, ADIPOQ, NPY, NPPB, HSD17B13, GNRH1

Biological processes related to amenorrhea according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	ovarian follicle development	GO:001541	10.5	NOBOX, FOXL2, FSHB, LHCGR, BMP15
2	positive regulation of male gonad development	GO:2000020	10.5	WT1, NR5A1, SRY
3	cellular response to gonadotropin stimulus	GO:071371	10.5	WT1, CYP17A1, LHCGR
4	adult feeding behavior	GO:008343	10.4	NPY, GHRL, LEP
5	positive regulation of steroid hormone biosynthetic process	GO:090031	10.4	POR, CYP17A1
6	eating behavior	GO:042755	10.3	OXT, PYY, TRH, LEP
7	sex differentiation	GO:007548	10.3	AR, CYP17A1, SRY
8	gonad development	GO:008406	10.3	CGA, FSHR, WT1
9	female gamete generation	GO:007292	10.2	DIAPH2, FSHR, FSHB, BMP15
10	male gonad development	GO:008584	10.2	WNT4, WT1, NR5A1, CYP19A1, AR, FSHR
11	peptide hormone processing	GO:016486	10.1	LHB, CGA, FSHB, POMC
12	positive regulation of cortisol secretion	GO:051464	10.1	CRH, GHRL
13	response to insulin stimulus	GO:032868	10.0	GAL, NPPA, AR, LEP
14	female pregnancy	GO:007565	10.0	NPPA, PRL, OXT, CRH, GNRH1, FSHB
15	adrenal gland development	GO:030325	10.0	APOA1, WNT4, WT1, CRH, NR5A1, CYP19A1
16	negative regulation of circadian sleep/wake cycle, REM sleep	GO:042322	9.9	CRH, GHRL
17	hormone-mediated signaling pathway	GO:009755	9.9	TRH, GHRL, GHR, LHCGR
18	response to estrogen stimulus	GO:043627	9.9	GAL, TNFRSF11B, GHRL, BGLAP
19	feeding behavior	GO:007631	9.8	GAL, NPY, CRH, PYY, CALCA
20	prostate gland growth	GO:060736	9.8	CYP19A1, IGF1, AR
21	response to drug	GO:042493	9.8	GAL, NPPB, POR, CYP19A1, CYP17A1, TNFRSF11B
22	negative regulation of blood pressure	GO:045776	9.7	CALCA, OXT, NPY, ADIPOQ
23	glucose metabolic process	GO:006006	9.6	ADIPOQ, SLC25A10, GHRL, INS, LEP
24	negative regulation of apoptotic process	GO:043066	9.5	WNT4, POR, WT1, GHRL, INS, AR
25	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.3	GH1, IGF1, IGFBP3, AR
26	regulation of blood pressure	GO:008217	9.3	NPPB, NPPA, POMC, CALCA, LEP
27	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	8.9	IGF1, GH1, GHR
28	cell-cell signaling	GO:007267	8.7	WNT4, POMC, NR5A1, PYY, TRH, CALCA
29	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.2	ADIPOQ, GHR, GH1, IGF1, INS, CD3E
30	positive regulation of glucose import	GO:046326	INF	ADIPOQ, IGF1, , INS
31	positive regulation of glycolysis	GO:045821	INF	IGF1, , INS
32	response to estradiol stimulus	GO:032355	INF	, GH1, GHR, CYP19A1, OXT
33	response to glucocorticoid stimulus	GO:051384	INF	BGLAP, , GHR, OXT, ADIPOQ
34	G-protein coupled receptor signaling pathway	GO:007186	INF	PYY, GHRL, APOA1, , INS, CD3E
35	response to ethanol	GO:045471	INF	ADIPOQ, TRH, GNRH1, , BGLAP
36	positive regulation of MAPK cascade	GO:043410	INF	IGF1, IGFBP3, , INS, AR, LEP
37	positive regulation of glycogen biosynthetic process	GO:045725	INF	INS, , IGF1

Molecular functions related to amenorrhea according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	9.8	GAL, NPY, CRH, PYY, TRH
2	peptide hormone receptor binding	GO:051428	9.5	NPPB, NPPA, LEP
3	receptor binding	GO:005102	7.7	ADIPOQ, NPY, NPPB, NPPA, POMC, CRH
4	hormone activity	GO:005179	6.2	LHB, ADIPOQ, NPPB, NPPA, POMC, PRL
5	insulin-like growth factor receptor binding	GO:005159	INF	INS, , IGF1