Aliases & Classifications for Amenorrhea

Aliases & Descriptions for Amenorrhea:

Name: Amenorrhea 12 29 42 14 69
Absence of Menstruation 12
Amenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13938
ICD10 33 N91.2
ICD9CM 35 626.0
MeSH 42 D000568
NCIt 47 C61443
UMLS 69 C0002453

Summaries for Amenorrhea

MalaCards based summary : Amenorrhea, also known as absence of menstruation, is related to leydig cell hypoplasia with pseudohermaphroditism and diabetes mellitus, insulin-resistant, with acanthosis nigricans, and has symptoms including ovulation bleeding An important gene associated with Amenorrhea is PRL (Prolactin), and among its related pathways/superpathways are Peptide ligand-binding receptors and DAG and IP3 signaling. The drugs Metformin and Cyproterone Acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and pituitary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 71 Amenorrhoea (BE), amenorrhea (AmE), or amenorrhœa, is the absence of a menstrual period in a woman of... more...

Related Diseases for Amenorrhea

Diseases related to Amenorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
id Related Disease Score Top Affiliating Genes
1 leydig cell hypoplasia with pseudohermaphroditism 31.5 FSHR LHCGR
2 diabetes mellitus, insulin-resistant, with acanthosis nigricans 30.9 GNRH1 NR5A1 SHBG
3 endometriosis 29.7 GNRH1 PRL
4 adrenal adenoma 29.4 LEP POMC SHBG
5 ahumada del castillo syndrome 11.1
6 premature ovarian failure 11.1
7 anorexia nervosa 11.0
8 polycystic ovary syndrome 11.0
9 perrault syndrome 10.9
10 aromatase deficiency 10.9
11 ovarian dysgenesis 2 10.8
12 satoyoshi syndrome 10.8
13 leukoencephalopathy with vanishing white matter 10.7
14 premature ovarian failure 8 10.7
15 hypogonadotropic hypogonadism 23 with or without anosmia 10.7
16 premature ovarian failure 9 10.7
17 premature ovarian failure 10 10.7
18 ovarian dysgenesis 1 10.7
19 premature ovarian failure 1 10.7
20 perrault syndrome 2 10.7
21 mullerian aplasia and hyperandrogenism 10.6
22 ovarian dysgenesis 4 10.6
23 premature ovarian failure 5 10.6
24 premature ovarian failure 7 10.6
25 autoimmune oophoritis 10.6
26 perrault syndrome 5 10.6
27 premature ovarian failure 2b 10.6
28 premature ovarian failure 6 10.6
29 hypogonadotropic hypogonadism 24 without anosmia 10.6
30 kallmann syndrome 10.6
31 perrault syndrome 4 10.6
32 pituitary adenoma, prolactin-secreting 10.6
33 blepharophimosis, epicanthus inversus, and ptosis, type 1 10.6
34 premature ovarian failure 3 10.6
35 ovarian dysgenesis 3 10.6
36 hypoplastic thumb mullerian aplasia 10.6
37 perrault syndrome 3 10.6
38 breast cancer 10.2
39 parathyroid adenoma 10.2 PRL SRY
40 abdominal aortic aneurysm 10.2 PRL SRY
41 diverticulitis 10.2 GNRH1 PRL
42 gershoni-baruch syndrome 10.2 PRL TRH
43 retroperitoneal sarcoma 10.1 GNRH1 PRL SHBG
44 gastric teratoma 10.1 PRL SRY
45 antisynthetase syndrome 10.1 NR5A1 SRY
46 papillary craniopharyngioma 10.1 GNRH1 PRL TRH
47 hypoglycemic coma 10.1 CRH GNRH1 TRH
48 edict syndrome 10.1 LEP PRL SHBG
49 acute thyroiditis 10.1 FSHR LHCGR PRL SHBG
50 cleft lip palate-tetraphocomelia 10.1 LEP POMC

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to Amenorrhea

Symptoms & Phenotypes for Amenorrhea

UMLS symptoms related to Amenorrhea:


ovulation bleeding

MGI Mouse Phenotypes related to Amenorrhea:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.17 POMC PRL TRH WNT4 BMP15 CRH
2 homeostasis/metabolism MP:0005376 10 LEP LHB LHCGR NR5A1 POMC PRL
3 integument MP:0010771 9.7 CRH FSHR GNRH1 LEP POMC PRL
4 nervous system MP:0003631 9.65 CRH FSHR GNRH1 LEP NOBOX NR5A1
5 reproductive system MP:0005389 9.36 BMP15 FSHB FSHR GNRH1 LEP LHB

Drugs & Therapeutics for Amenorrhea

Drugs for Amenorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 216)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
3
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757 53477783
4
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3,Phase 1 57-63-6 5991
5
Cyclophosphamide Approved, Investigational Phase 4,Phase 3 50-18-0, 6055-19-2 2907
6
Doxorubicin Approved, Investigational Phase 4,Phase 3 23214-92-8 31703
7
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
8
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2 797-63-7, 17489-40-6 13109
9
Leuprolide Approved, Investigational Phase 4,Phase 2 53714-56-0 3911 657181
10
Copper Approved Phase 4 15158-11-9, 7440-50-8 27099
11
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
12
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 71-58-9
13
Calcium carbonate Approved Phase 4,Phase 3 471-34-1
14
Menthol Approved Phase 4 2216-51-5 16666
15
Desogestrel Approved Phase 4,Phase 3 54024-22-5 40973
16
Tibolone Approved Phase 4 5630-53-5
17
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
19
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
20
Enclomiphene Investigational Phase 4,Phase 3,Phase 2 15690-57-0
21
Doxil Approved June 1999 Phase 4,Phase 3 31703
22 Clomiphene Phase 4,Phase 3,Phase 2
23 Hypoglycemic Agents Phase 4,Early Phase 1
24 Zuclomiphene Phase 4,Phase 3,Phase 2
25 Androgen Antagonists Phase 4,Phase 2
26 Androgens Phase 4,Phase 2
27 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Contraceptive Agents, Male Phase 4,Phase 2,Phase 3
29
Cyproterone Phase 4 2098-66-0 5284537
30 Estradiol 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1
31 Estradiol 3-benzoate Phase 4,Phase 3,Phase 2,Phase 1
32 Estradiol valerate Phase 4,Phase 3,Phase 2,Phase 1 979-32-8
33 Estrogens Phase 4,Phase 3,Phase 2,Phase 1
34 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
35 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
37 Polyestradiol phosphate Phase 4,Phase 3,Phase 2,Phase 1
38 Alkylating Agents Phase 4,Phase 3
39 Anti-Bacterial Agents Phase 4,Phase 3
40 Antibiotics, Antitubercular Phase 4,Phase 3
41 Antineoplastic Agents, Alkylating Phase 4,Phase 3
42 Antirheumatic Agents Phase 4,Phase 3,Phase 1
43 Immunosuppressive Agents Phase 4,Phase 3
44 Topoisomerase Inhibitors Phase 4,Phase 3
45 Micronutrients Phase 4,Phase 3
46 Trace Elements Phase 4,Phase 3
47 Vitamin B Complex Phase 4,Phase 3
48 Vitamins Phase 4,Phase 3
49 insulin Phase 4,Phase 2,Early Phase 1
50 Insulin, Globin Zinc Phase 4,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 202)
id Name Status NCT ID Phase
1 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4
2 CavatermTM vs TCRE in Women With DUB Unknown status NCT00549159 Phase 4
3 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4
4 Pharmacogenetics as a Predictor of Toxicity in Pre-Menopausal Women Receiving Doxorubicin and Cyclophosphamide in Early Breast Cancer Unknown status NCT00352872 Phase 4
5 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
6 Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients Completed NCT01206153 Phase 4
7 Safety and Efficacy of PROMETRIUM® Capsules in Induction of Secretory Conversion Completed NCT00160199 Phase 4
8 Endometrial Ablation With Non-hysteroscopic Methods Completed NCT01173965 Phase 4
9 Acceptability and Continuation Rate of Implanon in a Brazilian Public Sector Completed NCT01392157 Phase 4
10 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4
11 Effect of Hormone Replacement Therapy on Lupus Activity Completed NCT00392093 Phase 4
12 Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS) Recruiting NCT02500147 Phase 4
13 A Study to Compare the Menstrual Bleeding Profile Among Jaydess® and Copper Intrauterine Device (IUD) Users. COLIBRI STUDY (Copper and Levonorgestrel IUD Barcelona Research Initiative). Recruiting NCT02957292 Phase 4
14 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Recruiting NCT02904070 Phase 4
15 Contraceptive Pill and Hormonal Vaginal Ring in Women With Polycystic Ovary Syndrome Recruiting NCT01588873 Phase 4
16 Evaluation of 4th Generation Bipolar Radiofrequency Endometrial Ablation Device Active, not recruiting NCT02449304 Phase 4
17 Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Active, not recruiting NCT01463202 Phase 4
18 Psychological Impact of Amenorrhea in Women With Endometriosis Not yet recruiting NCT02393482 Phase 4
19 Tenofovir As Prevention Of Hepatitis b Mother-to-child Transmission Not yet recruiting NCT02937779 Phase 4
20 The Luveris In Vitro Fertilization Trial Terminated NCT00889512 Phase 4
21 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
22 Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study Unknown status NCT00746148 Phase 3
23 Reflexology's Effect on Polycystic Ovary Syndrome (PCOS) Unknown status NCT00744510 Phase 3
24 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed NCT01185782 Phase 3
25 PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata Completed NCT01629563 Phase 3
26 A Study to Evaluate of the Safety and Effectiveness of Asoprisnil in Treating Women With Uterine Fibroids Completed NCT00152256 Phase 3
27 Uterine Balloon Treatment for Heavy Period Bleeding. Completed NCT00215618 Phase 3
28 Evaluation Of Pessaries In Twin Pregnancies With A Short Cervix (25 mm) Between 20-28 WG (EPEGE) Completed NCT00502190 Phase 3
29 Endometrial Safety Study Completed NCT00522873 Phase 3
30 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3
31 Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer Completed NCT00427245 Phase 3
32 Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes Completed NCT00003782 Phase 3
33 The Effects of Tualang Honey on Postmenopausal Women Completed NCT01300676 Phase 2, Phase 3
34 Effects of Anorexia Nervosa on Bone Mass in Adolescents Completed NCT00088153 Phase 2, Phase 3
35 Endometrial Safety Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination Completed NCT00160316 Phase 3
36 Study of Safety and Efficacy of an Oral Contraceptive Completed NCT00391807 Phase 3
37 Vasomotoric Symptoms Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination Completed NCT00251082 Phase 3
38 Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis Completed NCT00808132 Phase 3
39 Postoperative Use of Zoledronic Acid in Breast Cancer Patients After Neoadjuvant Chemotherapy Completed NCT00512993 Phase 3
40 Comparison of Two Combination Chemotherapy Regimens in Treating Women With Breast Cancer Completed NCT00087178 Phase 3
41 Safety of Treatment of Uterine Fibroids With Asoprisnil Completed NCT00156208 Phase 3
42 A Study to Evaluate the Safety and Effectiveness of Asoprisnil in the Treatment of Uterine Fibroids Completed NCT00160381 Phase 3
43 Study to Evaluate the Safety of Asoprisnil in the Treatment of Uterine Fibroids Completed NCT00156195 Phase 3
44 Study of Asoprisnil in the Treatment of Uterine Fibroids. Completed NCT00156156 Phase 3
45 Treatment of Uterine Fibroids With Asoprisnil(J867) Completed NCT00152269 Phase 3
46 Risedronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy for Primary Breast Cancer Completed NCT00054418 Phase 3
47 The Effect of Post Ablation Medroxyprogesterone Acetate on Endometrial Amenorrhea Rates Recruiting NCT02449161 Phase 3
48 LutrePulse Hypogonadotropic Hypogonadism Recruiting NCT01976728 Phase 3
49 Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes Recruiting NCT00946192 Phase 3
50 HexafluOride, a Contrast Agent for Placenta Echo-angiography Recruiting NCT02884297 Phase 3

Search NIH Clinical Center for Amenorrhea

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: amenorrhea

Genetic Tests for Amenorrhea

Genetic tests related to Amenorrhea:

id Genetic test Affiliating Genes
1 Amenorrhea 29

Anatomical Context for Amenorrhea

MalaCards organs/tissues related to Amenorrhea:

39
Breast, Bone, Pituitary, Ovary, Testes, Endothelial, Thyroid

Publications for Amenorrhea

Articles related to Amenorrhea:

(show top 50) (show all 656)
id Title Authors Year
1
Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency. ( 28485330 )
2017
2
Serum kisspeptin concentrations are negatively correlated with body mass index in adolescents with anorexia nervosa and amenorrhea. ( 28500826 )
2017
3
Persistent amenorrhea and decreased DHEAS to cortisol ratio after recovery from anorexia nervosa. ( 27910716 )
2016
4
Novel homozygous nonsense mutations in the luteinizing hormone receptor (LHCGR) gene associated with 46,XY primary amenorrhea. ( 27016457 )
2016
5
Constrictive Pericarditis and Primary Amenorrhea with Syndactyly in an Iranian Female: Mulibrey Nanism Syndrome. ( 28496510 )
2016
6
Risk of chemotherapy-induced amenorrhea in patients with breast cancer: a systematic review and meta-analysis. ( 27105082 )
2016
7
Association of Thyroid Profile and Prolactin Level in Patient with Secondary Amenorrhea. ( 27904425 )
2016
8
Primary amenorrhea after bone marrow transplantation and adjuvant chemotherapy misdiagnosed as disorder of sex development: A case report. ( 27858857 )
2016
9
Amenorrhea in the Female Athlete: What to Do and When to Worry. ( 27031318 )
2016
10
Feature of amenorrhea in postoperative tamoxifen users with breast cancer. ( 27894163 )
2016
11
Short-term estriol administration modulates hypothalamo-pituitary function in patients with functional hypothalamic amenorrhea (FHA). ( 26634769 )
2016
12
Anti-Mullerian hormone levels do not predict response to pulsatile GnRH in women with hypothalamic amenorrhea. ( 26984343 )
2016
13
The physiology of functional hypothalamic amenorrhea associated with energy deficiency in exercising women and in women with anorexia nervosa. ( 26953710 )
2016
14
Pathogenic Features of Dysuria in Young Women with Secondary Amenorrhea Caused by Body Weight Loss. ( 27909963 )
2016
15
Comparison between pulsatile GnRH therapy and gonadotropins for ovulation induction in women with both functional hypothalamic amenorrhea and polycystic ovarian morphology. ( 27258574 )
2016
16
Effect of Temporary Ovarian Suppression on Chemotherapy-Induced Amenorrhea, Pregnancy, and Outcome. ( 27228206 )
2016
17
Spontaneous intermittent MRI changes of a pituitary stalk lesion causing diabetes insipidus and amenorrhea. ( 27655292 )
2016
18
Patients with secondary amenorrhea due to tuberculosis endometritis towards the induced anti-tuberculosis drug category 1. ( 27642459 )
2016
19
Embryonic testicular regression syndrome presenting as primary amenorrhea: a case report and review of disorders of sexual development. ( 27079915 )
2016
20
Low Resting Metabolic Rate in Exercise-Associated Amenorrhea is not Due to a Reduced Proportion of Energetically Expensive Tissue Compartments: 3858 Board #297 June 4, 9: 30 AM - 11: 00 AM. ( 27584532 )
2016
21
Laparoscopic Gonadectomy and Hernia Repair for Complete Androgen Insensitivity Syndrome (CAIS): A Rare Cause of Primary Amenorrhea. ( 27298532 )
2016
22
Does polycystic ovarian morphology influence the response to treatment with pulsatile GnRH in functional hypothalamic amenorrhea? ( 27129705 )
2016
23
Continuous amenorrhea may be insufficient to stop the progression of colorectal endometriosis. ( 27130533 )
2016
24
Case of a woman with acromegaly whose presenting complaint was prolonged post-partum amenorrhea. ( 27436485 )
2016
25
Prognostic Effects of Adjuvant Chemotherapy-Induced Amenorrhea and Subsequent Resumption of Menstruation for Premenopausal Breast Cancer Patients. ( 27057900 )
2016
26
Increased anti-Mullerian hormone levels and ovarian size in a subgroup of women with functional hypothalamic amenorrhea: further identification of the link between polycystic ovary syndrome and functional hypothalamic amenorrhea. ( 26767792 )
2016
27
Menses resumption after cancer treatment-induced amenorrhea occurs early or not at all. ( 26658130 )
2016
28
Disordered eating, amenorrhea, and substance use and misuse among professional ballet dancers: Preliminary analysis. ( 27044716 )
2016
29
SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study. ( 27234217 )
2016
30
Low resting metabolic rate in exercise-associated amenorrhea is not due to a reduced proportion of highly active metabolic tissue compartments. ( 27382033 )
2016
31
Association of baseline bleeding pattern on amenorrhea with levonorgestrel intrauterine system use. ( 27364099 )
2016
32
Tectal glioma presenting with clinical triad of obesity, amenorrhea and central cord syndrome with radiological pentad of hydrocephalus, empty sella, suprapineal diverticula, Chiari and syrinx. ( 27757566 )
2016
33
Progestin-Induced Amenorrhea May Not Prevent the Progression of Colorectal Endometriosis. ( 27329546 )
2016
34
Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome. ( 27089404 )
2016
35
Hormone Use for Therapeutic Amenorrhea and Contraception During Hematopoietic Cell Transplantation. ( 26348182 )
2015
36
Age, anti-mA1llerian hormone, antral follicles count to predict amenorrhea or oligomenorrhea after chemotherapy with cyclophosphamide. ( 26667243 )
2015
37
Chemotherapy-related amenorrhea after adjuvant paclitaxel-trastuzumab (APT trial). ( 25981899 )
2015
38
Neuroendocrine causes of amenorrhea--an update. ( 25581597 )
2015
39
Calcified Suprasellar Xanthogranuloma Presenting with Primary Amenorrhea in a 17-Year-Old Girl: Case Report and Literature Review. ( 25916181 )
2015
40
Amenorrhea after Endoscopic Third Ventriculostomy for a Failed Shunt in Spina Bifida: Case Report and Review of the Literature. ( 26550836 )
2015
41
Prognostic impact of chemotherapy-induced amenorrhea on premenopausal breast cancer: a meta-analysis of the literature. ( 25783467 )
2015
42
Prognostic Value of Chemotherapy-Induced Amenorrhea in Breast Cancer: a Meta-Analysis. ( 26320476 )
2015
43
[ROLE OF LEPTIN IN THE FORMATION OF SECONDARY AMENORRHEA IN ADOLESCENT GIRLS]. ( 27089723 )
2015
44
Hyperandrogenism in female athletes with functional hypothalamic amenorrhea: a distinct phenotype. ( 25610004 )
2015
45
Transition from the Lactational Amenorrhea Method to other modern family planning methods in rural Bangladesh: Barrier analysis and implications for behavior change communication program intervention design. ( 25710895 )
2015
46
A rare case of primary amenorrhea with two etiologies, hypothalamic amenorrhea, transverse vaginal septum, and no hematocolpos. ( 25785213 )
2015
47
Hot flashes and night sweats A^ amenorrhea A^ positive home pregnancy test A^ Dx? ( 26546959 )
2015
48
Primary amenorrhea with bilateral endometriotic cysts. ( 26008666 )
2015
49
Diurnal Variation of Plasma Brain-Derived Neurotrophic Factor Levels in Women with Functional Hypothalamic Amenorrhea. ( 25791538 )
2015
50
Chemotherapy-Related Amenorrhea and Menopause in Young Chinese Breast Cancer Patients: Analysis on Incidence, Risk Factors and Serum Hormone Profiles. ( 26485568 )
2015

Variations for Amenorrhea

Expression for Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for Amenorrhea

Pathways related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 CRH FSHB FSHR GNRH1 LEP LHB
2
Show member pathways
12.85 FSHB FSHR LHB LHCGR NR5A1 POMC
3
Show member pathways
12.23 LEP LHB LHCGR PRL
4
Show member pathways
11.97 FSHB LEP LHB POMC
5 11.8 CRH FSHB FSHR LHB LHCGR POMC
6 11.05 FSHR LHCGR NR5A1
7 11.05 BMP15 FSHB FSHR LHB LHCGR
8
Show member pathways
10.97 LEP POMC TRH
9 10.87 FSHB FSHR
10 10.75 GNRH1 SHBG
11 10.28 CRH POMC
12 10.14 FSHB FSHR GNRH1 LHB LHCGR

GO Terms for Amenorrhea

Cellular components related to Amenorrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 BMP15 CRH FSHB GNRH1 LEP LHB
2 extracellular region GO:0005576 9.36 BMP15 CRH FSHB GNRH1 LEP LHB
3 secretory granule GO:0030141 9.33 POMC PRL TRH

Biological processes related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.85 FSHB GNRH1 LHB NR5A1 POMC TRH
2 response to organic cyclic compound GO:0014070 9.8 GNRH1 PRL TRH
3 response to ethanol GO:0045471 9.72 CRH GNRH1 LEP PRL TRH
4 female gonad development GO:0008585 9.69 FSHR NR5A1 WNT4
5 peptide hormone processing GO:0016486 9.67 FSHB LHB POMC
6 female gamete generation GO:0007292 9.65 BMP15 FSHB FSHR
7 male gonad development GO:0008584 9.65 FSHR LHB LHCGR NR5A1 WNT4
8 sex differentiation GO:0007548 9.63 SRY WNT4
9 adrenal gland development GO:0030325 9.63 CRH NR5A1 WNT4
10 positive regulation of JAK-STAT cascade GO:0046427 9.62 LEP PRL
11 response to corticosterone GO:0051412 9.62 CRH TRH
12 positive regulation of adenylate cyclase activity GO:0045762 9.61 FSHR LHCGR
13 male sex determination GO:0030238 9.61 GNRH1 SRY
14 regulation of osteoclast differentiation GO:0045670 9.61 FSHB FSHR LHCGR
15 parturition GO:0007567 9.6 CRH PRL
16 ovulation cycle GO:0042698 9.59 GNRH1 PRL
17 regulation of steroid biosynthetic process GO:0050810 9.58 LEP NR5A1
18 positive regulation of male gonad development GO:2000020 9.58 NR5A1 SRY
19 hormone metabolic process GO:0042445 9.58 LEP NR5A1 WNT4
20 Sertoli cell proliferation GO:0060011 9.57 FSHB FSHR
21 progesterone biosynthetic process GO:0006701 9.56 FSHB LHB
22 negative regulation of glucagon secretion GO:0070093 9.54 CRH LEP
23 primary ovarian follicle growth GO:0001545 9.52 FSHR LHCGR
24 female pregnancy GO:0007565 9.35 CRH FSHB GNRH1 LEP PRL
25 follicle-stimulating hormone signaling pathway GO:0042699 9.33 FSHB FSHR LHCGR
26 hormone-mediated signaling pathway GO:0009755 9.1 FSHB FSHR LHB LHCGR NR5A1 TRH
27 signal transduction GO:0007165 10.2 CRH FSHB FSHR GNRH1 LEP LHB

Molecular functions related to Amenorrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.55 CRH LEP LHB POMC WNT4
2 G-protein coupled peptide receptor activity GO:0008528 9.32 FSHR LHCGR
3 protein-hormone receptor activity GO:0016500 9.26 FSHR LHCGR
4 hormone activity GO:0005179 9.23 CRH FSHB GNRH1 LEP LHB POMC
5 follicle-stimulating hormone receptor activity GO:0004963 8.96 FSHR LHCGR

Sources for Amenorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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