MCID: AMN001
MIFTS: 63

Amenorrhea malady

Summaries for Amenorrhea

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64Wikipedia, 33MalaCards
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Wikipedia:64 Amenorrhoea (BE), amenorrhea (AmE), or amenorrhœa, is the absence of a menstrual period in a woman of... more...

MalaCards: Amenorrhea, also known as absence of menstruation, is related to anorexia nervosa and anovulation. An important gene associated with Amenorrhea is POF1B (premature ovarian failure, 1B), and among its related pathways are Endogenous sterols and FSH signaling pathway. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds estrogen and leuprolide acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Amenorrhea

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
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Aliases & Descriptions:

amenorrhea 8 10 61
absence of menstruation 8
amenorrhoea nos 8
amenorrhea nos 8
amenorrhoea 8
amenia 8


External Ids:

Disease Ontology8 DOID:13938
MeSH35 D000568
ICD9CM27 626.0
NCIt40 C61443

Related Diseases for Amenorrhea

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Amenorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa30.7CRH, PRL, LEP
2anovulation30.4GNRH1, PRL, FSHR, LEP, CYP19A1
3hyperprolactinemia30.4PRL, CRH, GNRH1
4polycystic ovary syndrome30.4FSHB, FSHR, LEP, CYP17A1, CYP19A1, POR
5adenoma30.2LHCGR, GNRH1, CRH, PRL, NR5A1, POR
6systemic lupus erythematosus30.2PRL
7adrenal adenoma30.2CRH, CYP19A1, CYP17A1
8infertility30.2GNRH1, LHCGR, BMP15, AR, PRL, LGR6
9diabetes insipidus30.1PRL
10premature ovarian failure30.1LGR6, FSHR, PRL, BMP15, GNRH1
11uterine fibroid30.1GNRH1
12hyperandrogenism30.1CYP19A1, PRL, CRH, AR, GNRH1, LHCGR
13turner syndrome30.0GNRH1
14androgen insensitivity syndrome30.0SRY, AR
15insulin resistance30.0LEP, CYP17A1
16congenital adrenal hyperplasia30.0NR5A1, POR
17sertoli cell tumor30.0CYP19A1, AR
18short stature29.9GNRH1, PRL, CYP19A1, LEP, SRY
19pituitary apoplexy29.9GNRH1, PRL
20swyer syndrome29.7SRY
21hypogonadism, hypergonadotropic29.7FSHR, CYP19A1, PRL
22growth hormone deficiency29.7LEP, PRL, CRH
23adenocarcinoma29.7AR, NR5A1, FSHR
24complete androgen insensitivity syndrome29.7AR, CYP19A1
25acth-secreting pituitary adenoma29.7PRL, CRH
26precocious puberty29.7LHCGR, GNRH1, PRL, CYP19A1, LEP, FSHR
27hypoglycemia29.7GNRH1, CRH, PRL
28cushing's syndrome29.7LHCGR, GNRH1, CRH, PRL, POR, CYP17A1
29prolactinoma29.7GNRH1, PRL, NR5A1
30aromatase deficiency29.7CYP19A1
31osteoporosis10.3
32asherman's syndrome10.2
33satoyoshi syndrome10.1
34vaginal atresia10.1
35brain disease10.1
36acanthosis nigricans10.1
37empty sella syndrome10.1
38ahumada del castillo syndrome10.1
39forbes albright syndrome10.1
40ovarian dysgenesis 110.1
41neurosarcoidosis10.1
42hypogonadotropism10.0PRL, GNRH1
43hermaphroditism10.0SRY
44gonadal dysgenesis10.0SRY, NR5A1
45prostatic hypertrophy10.0AR, GNRH1
46mccune albright syndrome10.0GNRH1
47endogenous depression10.0CRH
48diabetes mellitus10.0LEP
49irritable bowel syndrome10.0CRH
50cytochrome p450 oxidoreductase deficiency10.0POR

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to amenorrhea

Clinical Features for Amenorrhea

Drugs & Therapeutics for Amenorrhea

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Amenorrhea

Anatomical Context for Amenorrhea

Sources:
33MalaCards
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MalaCards organs/tissues related to Amenorrhea:

33
Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Liver, Thyroid, Breast, Ovary, Uterus, Cervix, Myeloid, T cells, B cells, Endothelial, Adrenal cortex, Pituitary, Uterus corpus

Animal Models for Amenorrhea or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Amenorrhea

Sources:
51PubMed
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Articles related to Amenorrhea:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Metformin, oral contraceptives or both to manage oligo-amenorrhea in adolescents with polycystic ovary syndrome? A clinical review. (24405081)
2014
2
Chemotherapy-induced amenorrhea: a prospective study of brain activation changes and neurocognitive correlates. (23793983)
2013
3
Diagnostic pitfalls in the evaluation and management of amenorrhea in adolescents. (23947083)
2013
4
A Novel Nonsense Mutation in Exon 1 of HSD17B3 Gene in an Egyptian 46,XY Adult Female Presenting with Primary Amenorrhea. (23796702)
2013
5
Bilateral ectopic hypoplastic uteri attached to bilateral pelvic sidewalls in a 21-year-old patient with primary amenorrhea: the first published report. (24288635)
2013
6
The risk of amenorrhea is related to chemotherapy-induced leucopenia in breast cancer patients receiving epirubicin and taxane based chemotherapy. (22615953)
2012
7
Balanced autosomal translocation and double Robertsonian translocation in cases of primary amenorrhea in an Indian population. (22153613)
2012
8
17I+-hydroxlyase/17, 20-lyase deficiency in three siblings with primary amenorrhea and absence of secondary sexual development. (22841373)
2012
9
Incidence of chemotherapy-induced amenorrhea in premenopausal patients with breast cancer following adjuvant anthracycline and taxane. (21394515)
2011
10
Extended-use oral contraceptives and medically induced amenorrhea: attitudes, knowledge and prescribing habits of physicians. (21920194)
2011
11
Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B-producing thecoma and insights into the influence of inhibin B on LH. (20334861)
2010
12
"Persistence" improves the 60-day amenorrhea marker of entry to late-stage menopausal transition for women aged 40 to 44 years. (19713872)
2010
13
Analysis of chemotherapy-induced amenorrhea rates by three different anthracycline and taxane containing regimens for early breast cancer. (18506620)
2009
14
Determinants of recovery from amenorrhea in premenopausal breast cancer patients receiving adjuvant chemotherapy in the taxane era. (19339872)
2009
15
Should amenorrhea be a diagnostic criterion for anorexia nervosa? (19621464)
2009
16
Do estroprogestinic hormones protect against chemotherapy-induced amenorrhea in multiple sclerosis? (19030003)
2009
17
An unusual cause of primary amenorrhea. (18354032)
2008
18
Galactorrhea and amenorrhea in burn patients. (18403124)
2008
19
Primary amenorrhea in a young adult with sickle cell disease: a case report and brief literature review on adolescent reproductive health and sickle cell disease. (19064232)
2008
20
Secondary amenorrhea resulting from traumatic separation of the cervix from the uterine corpus. (17666653)
2007
21
Primary amenorrhea in non-identical twins: an improbable cause. (18082858)
2007
22
LH/FSH ratio: a better marker of secondary amenorrhea in patients from eastern Nepal. (18092428)
2007
23
Differentials of post-partum amenorrhea: a survival analysis. (18094740)
2007
24
Resumption of menses with initiation of letrozole after five years of amenorrhea on tamoxifen: caution needed when using tamoxifen followed by aromatase inhibitors. (16537187)
2006
25
Secondary amenorrhea. (16510552)
2006
26
Obesity may decrease the amenorrhea associated with chemotherapy in premenopausal breast cancer patients. (15668293)
2005
27
Recombinant human leptin in women with hypothalamic amenorrhea. (15564554)
2004
28
Body fat, leptin, and hypothalamic amenorrhea. (15342803)
2004
29
Treatment of secondary amenorrhea with abdomen acupuncture. (15119172)
2004
30
Current evaluation of amenorrhea. (15363691)
2004
31
Frequency of primary amenorrhea due to chromosomal aberration. (15233883)
2004
32
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
33
A review of the female athlete triad (amenorrhea, osteoporosis and disordered eating). (12467202)
2002
34
Diagnostic role of inhibin B in resistant ovary syndrome associated with secondary amenorrhea. (12477534)
2002
35
Increased adrenal steroid secretion in response to CRF in women with hypothalamic amenorrhea. (11595505)
2001
36
Ovulation induction with pulsatile gonadotropin-releasing hormone (GnRH) or gonadotropins in a case of hypothalamic amenorrhea and diabetes insipidus. (11826765)
2001
37
Hypothalamic amenorrhea. The effects of environmental stresses on the reproductive system: a central effect of the central nervous system. (11571933)
2001
38
Factors underlying changes in bone mineral during postpartum amenorrhea and lactation. (11069190)
2000
39
Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea. (10372709)
1999
40
Thalidomide induces amenorrhea in patients with lupus disease. (9870886)
1998
41
Continuous hormone replacement therapy for menopause combining nomegestrol acetate and gel, patch, or oral estrogen: a comparison of amenorrhea rates. (9829442)
1998
42
Unraveling the mystery of chronic amenorrhea. (9644450)
1998
43
Recommendations for exogenous estrogen to prevent glucocorticoid-induced osteoporosis in premenopausal women with oligo- or amenorrhea: comment on the American College of Rheumatology recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. (9259444)
1997
44
Clinical syndromes of secondary amenorrhea. (9238274)
1997
45
Bone mineral metabolism in diet-induced amenorrhea. (9238275)
1997
46
An inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46,XX female. (8923827)
1996
47
Recurrent generalized lichen nitidus associated with amenorrhea. (7915471)
1994
48
Amenorrhea and chronic anovulation. Finding and addressing the underlying cause. (1495882)
1992
49
Endocrine dynamics during pulsatile GnRH administration in patients with hypothalamic amenorrhea and polycystic ovarian disease. (2658471)
1989
50
Primary intrasellar germinoma in a woman presenting with secondary amenorrhea and hyperprolactinemia. (6483157)
1984

Genetic Variations for Amenorrhea

Expression for genes affiliated with Amenorrhea

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for genes affiliated with Amenorrhea

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
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Compounds for genes affiliated with Amenorrhea

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB
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Compounds related to Amenorrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8NR5A1, POR, LGR6
2leuprolide acetate4510.7GNRH1, FSHB, PRL, LHCGR, CYP19A1
3buserelin45 29 1112.7CYP19A1, FSHB, LHCGR, GNRH1, PRL
4danazol45 11 2412.7CYP19A1, GNRH1, AR, PRL
5cyproteroneacetate4510.7GNRH1, AR, CYP19A1, PRL
6clomiphene citrate4510.7CRH, FSHB, GNRH1, PRL, CYP19A1
7flutamide45 60 1112.7CYP19A1, PRL, AR, GNRH1, LHCGR
8letrozole45 50 60 1113.7LEP, CYP17A1, CYP19A1, AR
917-hydroxyprogesterone45 2411.6CYP19A1, POR, CYP17A1, GNRH1, CRH, PRL
10diethylstilbestrol45 29 1112.6POR, CYP17A1, CYP19A1, GNRH1, AR, NR5A1
11steroidal4510.6GNRH1, CYP17A1, CYP19A1, AR
123beta-hydroxysteroid4510.6POR, AR, LHCGR, CYP19A1, CYP17A1, NR5A1
13acth 1-244510.6CYP17A1, PRL, CRH
14progestin4510.6AR, PRL, LHCGR, CYP17A1, CYP19A1, GNRH1
15mifepristone45 60 29 1113.6CYP19A1, AR, GNRH1, PRL, CRH
16corticosterone45 60 2412.6NR5A1, PRL, CYP17A1, LEP, CRH, LHCGR
17dihydrotestosterone45 29 11 2413.6LEP, GNRH1, AR, PRL, POR, CYP17A1
18estrone45 29 11 2413.6PRL, AR, GNRH1, NR5A1, CYP19A1, CYP17A1
19naloxone45 50 29 1113.6LEP, PRL, CRH, GNRH1
20nifedipine45 50 29 1113.6CYP17A1, POR, LEP, CRH, GNRH1
21epinephrine45 11 2412.6GNRH1, AR, CRH, LEP, PRL, POR
22dehydroepiandrosterone sulfate4510.6GNRH1, LEP, CYP17A1, CYP19A1, NR5A1, PRL
23estradiol benzoate4510.6GNRH1, PRL, CYP19A1
24dhea4510.6CYP17A1, NR5A1, CYP19A1, POR, LEP, PRL
25acth4510.6GNRH1, CRH, PRL, NR5A1, CYP17A1, FSHB
26tamoxifen45 50 29 1113.6AR, GNRH1, CYP19A1, PRL, CYP17A1, LEP
27cocaine45 1111.5AR, CRH, GNRH1, LEP, PRL
28citalopram50 45 11 2413.5CRH, PRL, CYP19A1, LEP
29ribonucleic acid4510.5PRL, FSHB, CYP17A1, NR5A1, CRH, GNRH1
30ptx14510.5FSHB, NR5A1, GNRH1
31androstenedione45 2411.5CYP17A1, LEP, FSHR, CRH, CYP19A1, POR
32ketoconazole45 29 11 2413.5CRH, CYP17A1, AR, CYP19A1
3317beta-hydroxysteroid4510.5CYP17A1, CYP19A1, AR, NR5A1
34leuprolide45 60 29 1113.5PRL, AR, GNRH1
35vitamin d4510.5AR, NR5A1, POR, CYP19A1, CYP17A1, CRH
36adenylate4510.5CRH, FSHR, NR5A1, FSHB, LGR6, AR
37dexamethasone45 50 29 1113.5CYP17A1, GNRH1, AR, CRH, LEP, CYP19A1
38nilutamide45 60 29 1113.5GNRH1, POR, AR
39arginine4510.5GNRH1, LEP, CYP19A1, CYP17A1, POR, AR
40estradiol45 11 2412.4SRY, FSHB, FSHR, CYP17A1, CYP19A1, NR5A1
4111 deoxycortisol4510.4CRH, PRL, CYP17A1
42progesterone45 60 29 11 2414.4PRL, AR, BMP15, CRH, GNRH1, LHCGR
43goserelin45 29 1112.4CYP19A1, GNRH1, LHCGR
44serine4510.3LGR6, LHCGR, AR, CRH, POR, SRY
45gnrh4510.3LEP, FSHR, FSHB, AR, CYP17A1, CYP19A1
46steroid4510.3SRY, LHCGR, GNRH1, FSHB, FSHR, LEP
47testosterone45 60 11 2413.3FSHR, LEP, CYP17A1, CYP19A1, POR, NR5A1
48prostaglandin f2alpha4510.3LHCGR, GNRH1, LGR6, CRH
49cysteine4510.2SRY, LEP, CRH, FSHR
50metformin45 50 1112.0GNRH1, CYP19A1, LEP, CYP17A1

GO Terms for genes affiliated with Amenorrhea

Sources:
16Gene Ontology
See all sources

Biological processes related to Amenorrhea according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of steroid hormone biosynthetic processGO:09003110.7CYP17A1, POR
2follicle-stimulating hormone signaling pathwayGO:04269910.7FSHR, FSHB
3negative regulation of glucagon secretionGO:07009310.7LEP, CRH
4female gamete generationGO:00729210.7BMP15, FSHR, FSHB
5regulation of steroid biosynthetic processGO:05081010.7LEP, NR5A1
6positive regulation of male gonad developmentGO:200002010.7SRY, NR5A1
7adrenal gland developmentGO:03032510.7CYP17A1, NR5A1, CRH
8prostate gland growthGO:06073610.6AR, CYP19A1
9progesterone biosynthetic processGO:00670110.6LHB, FSHB
10ovarian follicle developmentGO:00154110.6NOBOX, FSHB, BMP15, LHCGR
11ovulation cycleGO:04269810.6PRL, GNRH1
12female pregnancyGO:00756510.6GNRH1, CRH, PRL, LEP, FSHB
13glucocorticoid biosynthetic processGO:00670410.6CYP17A1, CRH
14parturitionGO:00756710.6CRH, PRL
15male gonad developmentGO:00858410.6SRY, FSHR, NR5A1, AR, LHCGR, LHB
16cellular response to gonadotropin stimulusGO:07137110.5CYP17A1, LHCGR
17response to ethanolGO:04547110.5GNRH1, CRH, PRL
18cell-cell signalingGO:00726710.5NR5A1, AR, GNRH1, LHB
19hormone metabolic processGO:04244510.4NR5A1, LEP
20peptide hormone processingGO:01648610.4FSHB, LHB
21response to drugGO:04249310.4CYP17A1, POR, PRL, CRH
22sex differentiationGO:00754810.3CYP17A1, AR
23sterol metabolic processGO:01612510.1CYP17A1, CYP19A1

Molecular functions related to Amenorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.2FSHB, LEP, PRL, CRH, GNRH1, LHB

Products for genes affiliated with Amenorrhea

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Sources for Amenorrhea

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet