MCID: AMN001
MIFTS: 63

Amenorrhea malady

Summaries for Amenorrhea

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63Wikipedia, 32MalaCards
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Wikipedia:63 Amenorrhoea (BE), amenorrhea (AmE), or amenorrhœa, is the absence of a menstrual period in a woman of... more...

MalaCards: Amenorrhea, also known as absence of menstruation, is related to breast cancer and anorexia nervosa. An important gene associated with Amenorrhea is POF1B (premature ovarian failure, 1B), and among its related pathways are Endogenous sterols and FSH signaling pathway. The drugs bromocriptine and hydroxyprogesterone and the compounds estrogen and leuprolide acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and pituitary, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Amenorrhea

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

amenorrhea 8 10 60
absence of menstruation 8
amenorrhoea nos 8
amenorrhea nos 8
amenorrhoea 8
amenia 8


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Disease Ontology8 DOID:13938
MeSH34 D000568
ICD9CM27 626.0
NCIt39 C61443

Related Diseases for Amenorrhea

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17GeneCards, 18GeneDecks
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Diseases related to Amenorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.8LHCGR, GNRH1, AR, PRL, NR5A1, POR
2anorexia nervosa30.7CRH, PRL, LEP
3eating disorder30.6LEP
4anovulation30.4GNRH1, PRL, FSHR, LEP, CYP19A1
5hyperprolactinemia30.3PRL, CRH, GNRH1
6hyperandrogenism30.3CYP19A1, PRL, CRH, AR, GNRH1, LHCGR
7polycystic ovary syndrome30.3FSHB, FSHR, LEP, CYP17A1, CYP19A1, POR
8gonadal dysgenesis30.3SRY, NR5A1
9hypogonadotropism30.2PRL, GNRH1
10ovarian disease30.2FSHR, PRL, GNRH1
11adenoma30.2LHCGR, GNRH1, CRH, PRL, NR5A1, POR
12infertility30.2GNRH1, LHCGR, BMP15, AR, PRL, LGR6
13systemic lupus erythematosus30.1PRL
14hypothalamic disease30.1PRL, CRH, GNRH1
15adrenal adenoma30.1CRH, CYP19A1, CYP17A1
16diabetes insipidus30.0PRL
17premature ovarian failure30.0LGR6, FSHR, PRL, BMP15, GNRH1
18uterine fibroid30.0GNRH1
19turner syndrome29.9GNRH1
20endogenous depression29.9CRH
21androgen insensitivity syndrome29.9SRY, AR
22congenital adrenal hyperplasia29.9NR5A1, POR
23sertoli cell tumor29.9CYP19A1, AR
24leydig cell tumor29.9LHCGR, GNRH1, NR5A1, CYP19A1, CYP17A1
25hypothyroidism29.9GNRH1, PRL, LEP, FSHR
26pituitary apoplexy29.9GNRH1, PRL
27obesity29.9AR, CRH, NR5A1, LEP, FSHR
28ovarian cancer29.9LHCGR, GNRH1, AR, POR, CYP19A1, CYP17A1
29hypogonadism29.9LGR6, FSHB, FSHR, LEP, CYP19A1, NR5A1
30hermaphroditism29.7SRY
31diabetes mellitus29.7LEP
32leiomyoma29.7CYP17A1, CYP19A1, GNRH1
33adenocarcinoma29.7AR, NR5A1, FSHR
34hypopituitarism29.7LEP, PRL, CRH, GNRH1
35sexual disorder29.7PRL, GNRH1
36hypertension29.7LEP, CYP17A1, CRH
37hyperthyroidism29.7FSHR, LEP, PRL
38acth-secreting pituitary adenoma29.7PRL, CRH
39hypoglycemia29.7GNRH1, CRH, PRL
40cushing's syndrome29.7LHCGR, GNRH1, CRH, PRL, POR, CYP17A1
41pituitary adenoma29.7GNRH1, CRH, PRL, NR5A1, LEP, FSHR
42prolactinoma29.7GNRH1, PRL, NR5A1
43aromatase deficiency29.7CYP19A1
44osteoporosis10.3
45calloso-genital dysplasia10.2
46lupus erythematosus10.1
47satoyoshi syndrome10.1
48brain disease10.1
49acanthosis nigricans10.0
50empty sella syndrome10.0

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to amenorrhea

Clinical Features for Amenorrhea

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Drugs & Therapeutics for Amenorrhea

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Amenorrhea

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Anatomical Context for Amenorrhea

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32MalaCards
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MalaCards organs/tissues related to Amenorrhea:

32
Breast, Bone, Pituitary, Ovary, Testes, Endothelial, Uterus, Thyroid, Spinal cord, Cortex, Brain, Liver, Cervix, Myeloid, Heart, Adrenal cortex

Animal Models for Amenorrhea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Amenorrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2GNRH1, AR, CRH, PRL, CYP19A1, LEP
2MP:000537010.2GNRH1, AR, PRL, POR, CYP19A1, LEP
3MP:000538610.2LHCGR, AR, CRH, PRL, NR5A1, POR
4MP:000287310.2LGR6, CYP19A1, POF1B, NR5A1, CRH, AR
5MP:000538410.2AR, GNRH1, LHCGR, LHB, CRH, NR5A1
6MP:000537610.1LHB, LHCGR, GNRH1, AR, CRH, PRL
7MP:000538910.0SRY, LHB, LHCGR, GNRH1, PSMC3IP, BMP15
8MP:000363110.0GNRH1, AR, CRH, PRL, NR5A1, POR
9MP:000537910.0AR, BMP15, PSMC3IP, GNRH1, LHCGR, LHB
10MP:000537510.0LHCGR, AR, CYP19A1, LEP, FSHR

Publications for Amenorrhea

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50PubMed
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Articles related to Amenorrhea:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Frequency and the type of chromosomal abnormalities in patients with primary amenorrhea in northeast of iran. (24250944)
2013
2
Prevalence of chromosomal abnormalities in Sri Lankan women with primary amenorrhea. (23279116)
2013
3
Hypothalamic amenorrhea in a Camurati-Engelmann disease--a case report. (23368730)
2013
4
Hyperprolactinemia and hyperandrogenism in an adolescent girl presenting with primary amenorrhea. (23182426)
2013
5
Incidence and predictors of ovarian function recovery (OFR) in breast cancer (BC) patients with chemotherapy-induced amenorrhea (CIA) who switched from tamoxifen to exemestane. (23108951)
2013
6
5-alpha-reductase 2 deficiency in a woman with primary amenorrhea. (24383016)
2013
7
Chromosomal abnormality in patients with secondary amenorrhea. (22424042)
2012
8
Cytogenetic investigation of patients with primary amenorrhea. (22754234)
2012
9
Chromosomal abnormalities and hormonal disorders of primary amenorrhea patients in Egypt. (23162293)
2012
10
Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea. (20414046)
2011
11
A genetic basis for functional hypothalamic amenorrhea. (21247312)
2011
12
Clinical practice. Functional hypothalamic amenorrhea. (20660404)
2010
13
Secondary amenorrhea attributed to occlusion of microperforate transverse vaginal septum. (20188359)
2010
14
Serum levels of tryptophan, 5-hydroxytryptophan and serotonin in patients affected with different forms of amenorrhea. (22084589)
2010
15
Amenorrhea from breast cancer therapy--not a matter of dose. (21121855)
2010
16
Secondary amenorrhea with low serum luteinizing hormone and follicle-stimulating hormone caused by an inhibin A- and inhibin B-producing granulosa cell tumor. (19346197)
2009
17
Primary amenorrhea revealing an occult progesterone-secreting ovarian tumor. (18304537)
2008
18
A 12Mb deletion at 7q33-q35 associated with autism spectrum disorders and primary amenorrhea. (18675947)
2008
19
Amenorrhea and resumption of menstruation after uterine artery embolization for fibroids. (18768179)
2008
20
Relationship between adolescent amenorrhea and climacteric osteoporosis. (17161926)
2007
21
Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea. (17284620)
2007
22
Retrospective reporting of the duration of post-partum amenorrhea: a survival analysis. (18603900)
2006
23
Chemotherapy for acute myeloid leukemias with cytosine arabinoside, daunorubicin, etoposide, and mitoxantrone may cause permanent oligoasthenozoospermia or amenorrhea in middle-aged patients. (16151584)
2005
24
Amenorrhea in female athletes is associated with endothelial dysfunction and unfavorable lipid profile. (15572426)
2005
25
Osteoporosis and amenorrhea in a young patient with von Hippel-Lindau disease. (15658149)
2005
26
The genetics, diagnosis and treatment of amenorrhea. (15531861)
2004
27
Incidence of chemotherapy-induced amenorrhea depending on the timing of treatment by menstrual cycle phase in women with early breast cancer. (15205200)
2004
28
Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. (12749436)
2003
29
Persistent osteopenia in ballet dancers with amenorrhea and delayed menarche despite hormone therapy: a longitudinal study. (12909505)
2003
30
Permanent amenorrhea associated with endometrial atrophy after uterine artery embolization for symptomatic uterine fibroids. (12524076)
2003
31
Intervillous and spiral artery flows in normal pregnancies between 5 and 10 weeks of amenorrhea using color Doppler ultrasonography. (11914569)
2002
32
Infant feeding and lactational amenorrhea in Sagamu, Nigeria. (12484341)
2002
33
Gonadotropin-releasing hormone for infertility in women with primary hypothalamic amenorrhea. Toward a more-interventional approach. (11209627)
2001
34
Pivagabine decreases stress-related hormone secretion in women with hypothalamic amenorrhea. (11021769)
2000
35
Hypothalamic amenorrhea with normal body weight: ACTH, allopregnanolone and cortisol responses to corticotropin-releasing hormone test. (10700723)
2000
36
Identification of allelic variants in the follicle-stimulating hormone receptor genes of females with or without hypergonadotropic amenorrhea. (9696229)
1998
37
Gynecology case challenge--persistent amenorrhea postpartum. (9732094)
1998
38
The World Health Organization Multinational Study of Breast-feeding and Lactational Amenorrhea. I. Description of infant feeding patterns and of the return of menses. World Health Organization Task Force on Methods for the Natural Regulation of Fertility. (9757873)
1998
39
The World Health Organization Multinational Study of Breast-feeding and Lactational Amenorrhea. II. Factors associated with the length of amenorrhea. World Health Organization Task Force on Methods for the Natural Regulation of Fertility. (9757874)
1998
40
Multicenter study of the Lactational Amenorrhea Method (LAM): I. Efficacy, duration, and implications for clinical application. (9262927)
1997
41
Secondary amenorrhea leading to osteoporosis: incidence and prevention. (9172234)
1997
42
Endocrine causes of amenorrhea. (9384139)
1997
43
Effects of exercise and amenorrhea on bone mineral density in teenage runners. (7627272)
1995
44
Neurosarcoidosis presenting as secondary amenorrhea in a teenager. (8241204)
1993
45
Lactational amenorrhea. (8449188)
1993
46
Lymphocytic hypophysitis in a patient with amenorrhea and hyperprolactinemia. A case report. (3701721)
1986
47
Pulsatile luteinizing hormone patterns in the follicular phase of the menstrual cycle, polycystic ovarian disease (PCOD) and non-PCOD secondary amenorrhea. (3932449)
1985
48
Primary amenorrhea associated with hirsutism, acanthosis nigricans, dermoid cysts of the ovaries and a new type of insulin resistance. (686026)
1978
49
Amenorrhea: symptom of endogenous depression. (4509130)
1972
50
TREATMENT OF AMENORRHEA AND OF ANOVULATION WITH HUMAN MENOPAUSAL AND CHORIONIC GONADOTROPINS. (14268491)
1965

Genetic Variations for Amenorrhea

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Expression for genes affiliated with Amenorrhea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for genes affiliated with Amenorrhea

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Amenorrhea

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Amenorrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8NR5A1, POR, LGR6
2leuprolide acetate4410.7GNRH1, FSHB, PRL, LHCGR, CYP19A1
3buserelin44 28 1112.7CYP19A1, FSHB, LHCGR, GNRH1, PRL
4danazol44 11 2412.7CYP19A1, GNRH1, AR, PRL
5cyproteroneacetate4410.7GNRH1, AR, CYP19A1, PRL
6clomiphene citrate4410.7CRH, FSHB, GNRH1, PRL, CYP19A1
7flutamide44 59 1112.7CYP19A1, PRL, AR, GNRH1, LHCGR
8letrozole44 49 59 1113.7LEP, CYP17A1, CYP19A1, AR
917-hydroxyprogesterone44 2411.6CYP19A1, POR, CYP17A1, GNRH1, CRH, PRL
10diethylstilbestrol44 28 1112.6POR, CYP17A1, CYP19A1, GNRH1, AR, NR5A1
11steroidal4410.6GNRH1, CYP17A1, CYP19A1, AR
123beta-hydroxysteroid4410.6POR, AR, LHCGR, CYP19A1, CYP17A1, NR5A1
13acth 1-244410.6CYP17A1, PRL, CRH
14progestin4410.6AR, PRL, LHCGR, CYP17A1, CYP19A1, GNRH1
15mifepristone44 59 28 1113.6CYP19A1, AR, GNRH1, PRL, CRH
16corticosterone44 59 2412.6NR5A1, PRL, CYP17A1, LEP, CRH, LHCGR
17dihydrotestosterone44 28 11 2413.6LEP, GNRH1, AR, PRL, POR, CYP17A1
18estrone44 28 11 2413.6PRL, AR, GNRH1, NR5A1, CYP19A1, CYP17A1
19naloxone44 49 28 1113.6LEP, PRL, CRH, GNRH1
20nifedipine44 49 28 1113.6CYP17A1, POR, LEP, CRH, GNRH1
21epinephrine44 11 2412.6GNRH1, AR, CRH, LEP, PRL, POR
22dehydroepiandrosterone sulfate4410.6GNRH1, LEP, CYP17A1, CYP19A1, NR5A1, PRL
23estradiol benzoate4410.6GNRH1, PRL, CYP19A1
24dhea4410.6CYP17A1, NR5A1, CYP19A1, POR, LEP, PRL
25acth4410.6GNRH1, CRH, PRL, NR5A1, CYP17A1, FSHB
26tamoxifen44 49 28 1113.6AR, GNRH1, CYP19A1, PRL, CYP17A1, LEP
27cocaine44 1111.5AR, CRH, GNRH1, LEP, PRL
28citalopram49 44 11 2413.5CRH, PRL, CYP19A1, LEP
29ribonucleic acid4410.5PRL, FSHB, CYP17A1, NR5A1, CRH, GNRH1
30ptx14410.5FSHB, NR5A1, GNRH1
31androstenedione44 2411.5CYP17A1, LEP, FSHR, CRH, CYP19A1, POR
32ketoconazole44 28 11 2413.5CRH, CYP17A1, AR, CYP19A1
3317beta-hydroxysteroid4410.5CYP17A1, CYP19A1, AR, NR5A1
34leuprolide44 59 28 1113.5PRL, AR, GNRH1
35vitamin d4410.5AR, NR5A1, POR, CYP19A1, CYP17A1, CRH
36adenylate4410.5CRH, FSHR, NR5A1, FSHB, LGR6, AR
37dexamethasone44 49 28 1113.5CYP17A1, GNRH1, AR, CRH, LEP, CYP19A1
38nilutamide44 59 28 1113.5GNRH1, POR, AR
39arginine4410.5GNRH1, LEP, CYP19A1, CYP17A1, POR, AR
40estradiol44 11 2412.4SRY, FSHB, FSHR, CYP17A1, CYP19A1, NR5A1
4111 deoxycortisol4410.4CRH, PRL, CYP17A1
42progesterone44 59 28 11 2414.4PRL, AR, BMP15, CRH, GNRH1, LHCGR
43goserelin44 28 1112.4CYP19A1, GNRH1, LHCGR
44serine4410.3LGR6, LHCGR, AR, CRH, POR, SRY
45gnrh4410.3LEP, FSHR, FSHB, AR, CYP17A1, CYP19A1
46steroid4410.3SRY, LHCGR, GNRH1, FSHB, FSHR, LEP
47testosterone44 59 11 2413.3FSHR, LEP, CYP17A1, CYP19A1, POR, NR5A1
48prostaglandin f2alpha4410.3LHCGR, GNRH1, LGR6, CRH
49cysteine4410.2SRY, LEP, CRH, FSHR
50metformin44 49 1112.0GNRH1, CYP19A1, LEP, CYP17A1

GO Terms for genes affiliated with Amenorrhea

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16Gene Ontology
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Biological processes related to Amenorrhea according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of steroid hormone biosynthetic processGO:09003110.7CYP17A1, POR
2follicle-stimulating hormone signaling pathwayGO:04269910.7FSHR, FSHB
3negative regulation of glucagon secretionGO:07009310.7LEP, CRH
4female gamete generationGO:00729210.7BMP15, FSHR, FSHB
5regulation of steroid biosynthetic processGO:05081010.7LEP, NR5A1
6positive regulation of male gonad developmentGO:200002010.7SRY, NR5A1
7adrenal gland developmentGO:03032510.7CYP17A1, NR5A1, CRH
8prostate gland growthGO:06073610.6AR, CYP19A1
9progesterone biosynthetic processGO:00670110.6LHB, FSHB
10ovarian follicle developmentGO:00154110.6NOBOX, FSHB, BMP15, LHCGR
11ovulation cycleGO:04269810.6PRL, GNRH1
12female pregnancyGO:00756510.6GNRH1, CRH, PRL, LEP, FSHB
13glucocorticoid biosynthetic processGO:00670410.6CYP17A1, CRH
14parturitionGO:00756710.6CRH, PRL
15male gonad developmentGO:00858410.6SRY, FSHR, NR5A1, AR, LHCGR, LHB
16cellular response to gonadotropin stimulusGO:07137110.5CYP17A1, LHCGR
17response to ethanolGO:04547110.5GNRH1, CRH, PRL
18cell-cell signalingGO:00726710.5NR5A1, AR, GNRH1, LHB
19hormone metabolic processGO:04244510.4NR5A1, LEP
20peptide hormone processingGO:01648610.4FSHB, LHB
21response to drugGO:04249310.4CYP17A1, POR, PRL, CRH
22sex differentiationGO:00754810.3CYP17A1, AR
23sterol metabolic processGO:01612510.1CYP17A1, CYP19A1

Molecular functions related to Amenorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.2FSHB, LEP, PRL, CRH, GNRH1, LHB

Products for genes affiliated with Amenorrhea

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Sources for Amenorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet