Summaries for Amenorrhea

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Wikipedia:63 Amenorrhoea (BE), amenorrhea (AmE), or amenorrh?a, is the absence of a menstrual period in a woman of... more...

MalaCards based summary: Amenorrhea, also known as absence of menstruation, is related to cushing's syndrome and oligomenorrhea. An important gene associated with Amenorrhea is POF1B (premature ovarian failure, 1B), and among its related pathways are Ovarian Infertility Genes and Transcription CREM signaling in testis. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds nilutamide and estradiol benzoate have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and pituitary, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Amenorrhea

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Amenorrhea, Aliases & Descriptions:

Name: Amenorrhea 9 11 60
Absence of Menstruation 9
Amenorrhoea Nos 9
 
Amenorrhea Nos 9
Amenorrhoea 9
Amenia 9


External Ids:

Disease Ontology9 DOID:13938
ICD9CM27 626.0
NCIt38 C61443
MeSH33 D000568

Related Diseases for Amenorrhea

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Diseases related to Amenorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome30.7PRL
2oligomenorrhea30.7GNRH1, PRL
3turner syndrome30.7GNRH1
4hypogonadotropism30.7GNRH1, PRL
5hyperprolactinemia30.6PRL, GNRH1
6anovulation30.6PRL, FSHR, GNRH1
7premature ovarian failure30.6FSHR, PRL
8ovarian disease30.4PRL, FSHR, GNRH1
9pituitary apoplexy30.3GNRH1, PRL
10hypothalamic disease30.3GNRH1, PRL
11breast cancer30.3LHCGR, PRL, POR, GNRH1
12hyperandrogenism30.2FSHR, PRL, GNRH1, LHCGR
13swyer syndrome30.2SRY
14leydig cell tumor30.1LHCGR, GNRH1
15polycystic ovary syndrome30.1FSHR, PRL, GNRH1, LHCGR
16hypopituitarism30.0PRL, GNRH1
17hypothyroidism30.0PRL, FSHR, GNRH1
18prolactinoma29.9GNRH1, PRL
19hypoglycemia29.9PRL, GNRH1
20congenital adrenal hyperplasia29.9GNRH1, POR, SRY
21hyperthyroidism29.8FSHR, PRL
22precocious puberty29.5GNRH1, FSHR, PRL, LHCGR
23pituitary tumors29.4GNRH1, FSHB, FSHR, PRL
24adenoma29.4GNRH1, LHCGR, FSHR, FSHB, PRL, POR
25hypogonadism29.3FSHB, GNRH1, LHCGR, PRL, FSHR
26infertility29.1PRL, FSHB, SRY, LHCGR, GNRH1, FSHR
27anorexia nervosa10.5
28mccune-albright syndrome, somatic, mosaic10.4GNRH1
29prostatic hypertrophy10.4GNRH1
30osteoporosis10.3
31eating disorder10.3
32penile disease10.3GNRH1, PRL
33sexual disorder10.2PRL, GNRH1
34gonadal dysgenesis10.2
35diabetes insipidus, neurohypophyseal10.2PRL, GNRH1
36varicocele10.2PRL, GNRH1
37calloso-genital dysplasia10.2
38pituitary gland disease10.2GNRH1, PRL
39perrault syndrome10.2
40vaginitis10.2
41blindness10.2
42gonadal disease10.2FSHR, GNRH1
43penis agenesis10.2GNRH1, LHCGR
44testotoxicosis10.2FSHR, LHCGR
45leiomyomatosis10.2GNRH1, LHCGR
46systemic lupus erythematosus10.2
47frasier syndrome10.2
48adrenal adenoma10.2
49lupus erythematosus10.2
5046,xx testicular disorder of sex development10.2

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to amenorrhea

Symptoms for Amenorrhea

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Drugs & Therapeutics for Amenorrhea

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Genetic Tests for Amenorrhea

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Anatomical Context for Amenorrhea

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MalaCards organs/tissues related to Amenorrhea:

31
Breast, Bone, Pituitary, Ovary, Testes, Endothelial, Spinal cord, Thyroid, Uterus, Brain, Cortex, Heart, Liver, Cervix, Myeloid, Adrenal cortex

Animal Models for Amenorrhea or affiliated genes

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MGI Mouse Phenotypes related to Amenorrhea:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6FSHR, FSHB, PRL, POR, GNRH1, LHCGR
2MP:00053796.8LHCGR, GNRH1, PRL, FSHB, FSHR, SRY
3MP:00053896.6SRY, LHCGR, GNRH1, POR, PRL, FSHB

Publications for Amenorrhea

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Articles related to Amenorrhea:

(show top 50)    (show all 595)
idTitleAuthorsYear
1
Prognostic impact of chemotherapy-induced amenorrhea on premenopausal breast cancer: a meta-analysis of the literature. (25783467)
2015
2
A rare case of primary amenorrhea with two etiologies, hypothalamic amenorrhea, transverse vaginal septum, and no hematocolpos. (25785213)
2015
3
Transition from the Lactational Amenorrhea Method to other modern family planning methods in rural Bangladesh: Barrier analysis and implications for behavior change communication program intervention design. (25710895)
2015
4
Functional hypothalamic amenorrhea and its influence on women's health. (25201001)
2014
5
Emergency contraceptive pills as a backup for lactational amenorrhea method (LAM) of contraception: a randomized controlled trial. (22935323)
2013
6
Using an algorithmic approach to secondary amenorrhea: Avoiding diagnostic error. (23588065)
2013
7
Frequency and the type of chromosomal abnormalities in patients with primary amenorrhea in northeast of iran. (24250944)
2013
8
Amenorrhea in women treated with thalidomide: report of two cases and literature review. (22161965)
2013
9
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. (22353374)
2012
10
Incidence of chemotherapy-induced amenorrhea in premenopausal patients with breast cancer following adjuvant anthracycline and taxane. (21394515)
2011
11
Taxane-based regimens as a risk factor for chemotherapy-induced amenorrhea. (21037487)
2011
12
Unexplained amenorrhea in a patient taking methotrexate for the treatment of rheumatoid arthritis. (19916871)
2010
13
Amenorrhea and "man hands". (20303484)
2010
14
Influence of ghrelin and adipocytokines on bone mineral density in adolescent female athletes with amenorrhea and eumenorrheic athletes. (20956863)
2010
15
Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B-producing thecoma and insights into the influence of inhibin B on LH. (20334861)
2010
16
Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea. (20237833)
2010
17
Clinical practice. Functional hypothalamic amenorrhea. (20660404)
2010
18
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. (19129711)
2009
19
Bone Health and Falls: Fracture Risk in Breast Cancer Survivors With Chemotherapy-Induced Amenorrhea. (19596649)
2009
20
Secondary amenorrhea with low serum luteinizing hormone and follicle-stimulating hormone caused by an inhibin A- and inhibin B-producing granulosa cell tumor. (19346197)
2009
21
Absence of endometrium as a cause of primary amenorrhea. (17531232)
2008
22
Stress-associated or functional hypothalamic amenorrhea in the adolescent. (18574223)
2008
23
Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and Muellerian duct abnormalities: a French collaborative study. (18182450)
2008
24
Functional hypothalamic amenorrhea: current view on neuroendocrine aberrations. (18224538)
2008
25
Secondary amenorrhea resulting from traumatic separation of the cervix from the uterine corpus. (17666653)
2007
26
Serum anti-mA1llerian hormone levels in women with secondary amenorrhea. (16616745)
2006
27
Current evaluation of amenorrhea. (17055812)
2006
28
Primary amenorrhea. Varied etiology. (16155669)
2005
29
Chemotherapy for acute myeloid leukemias with cytosine arabinoside, daunorubicin, etoposide, and mitoxantrone may cause permanent oligoasthenozoospermia or amenorrhea in middle-aged patients. (16151584)
2005
30
Secondary amenorrhea after Hodgkin's lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: a report from the German Hodgkin's Lymphoma Study Group. (16234521)
2005
31
Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. (12749436)
2003
32
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
33
A complex mosaicism 45,X/46,X,del(Xq)/46,X,idic(Xq) in a patient with secondary amenorrhea. (12381444)
2002
34
A review of the female athlete triad (amenorrhea, osteoporosis and disordered eating). (12467202)
2002
35
Meeting the needs of young women with secondary amenorrhea and spontaneous premature ovarian failure. (11978278)
2002
36
Breastfeeding, amenorrhea and contraceptive practice among postpartum women in Zibo, China. (12428929)
2002
37
Lactational amenorrhea/anovulation and some of their determinants: a comparison of well-nourished and undernourished women. (11476779)
2001
38
A longitudinal study of disturbances of the hypothalamic-pituitary-adrenal axis in women with progestin-negative functional hypothalamic amenorrhea. (11591409)
2001
39
Understanding the female athlete triad: eating disorders, amenorrhea, and osteoporosis. (10544368)
1999
40
Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea. (9768680)
1998
41
Identification of allelic variants in the follicle-stimulating hormone receptor genes of females with or without hypergonadotropic amenorrhea. (9696229)
1998
42
Evaluation and management of amenorrhea. (9413300)
1997
43
Clinical syndromes of primary amenorrhea. (9238273)
1997
44
An inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46,XX female. (8923827)
1996
45
Hypothalamic amenorrhea: evidence for a central derangement of hypothalamic-pituitary-adrenal cortex axis activity. (8384575)
1993
46
Lynestrenol induced therapeutic amenorrhea: effects of dose reduction on serum sex-hormones and lipids. (1317638)
1992
47
Ten-year follow-up of patients with secondary amenorrhea and normal prolactin. (2048615)
1991
48
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 22-1988. A 13-year-old girl with secondary amenorrhea, obesity, acanthosis nigricans, and hirsutism. (3367952)
1988
49
Amenorrhea associated with carotenemia. (6876328)
1983
50
46, XY gonadal dysgenesis with secondary amenorrhea, virilization, and bilateral gonadoblastomas. (572994)
1979

Variations for Amenorrhea

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Expression for genes affiliated with Amenorrhea

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Search GEO for disease gene expression data for Amenorrhea.

Pathways for genes affiliated with Amenorrhea

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Pathways related to Amenorrhea according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4FSHR, LHCGR
29.3FSHR, FSHB
39.3FSHB, FSHR
4
Show member pathways
8.8FSHR, FSHB, LHCGR
58.8FSHR, FSHB, LHCGR
68.8FSHR, FSHB, LHCGR
78.4GNRH1, FSHR, FSHB, LHCGR
8
Show member pathways
7.9FSHB, PRL, GNRH1, FSHR, LHCGR
9
Show member pathways
7.9FSHR, GNRH1, LHCGR, PRL, FSHB

Compounds for genes affiliated with Amenorrhea

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Compounds related to Amenorrhea according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1nilutamide43 59 28 1213.0POR, GNRH1
2estradiol benzoate4310.0GNRH1, PRL
3leuprolide43 59 28 1213.0PRL, GNRH1
4mhpg4310.0PRL, GNRH1
5toremifene43 1210.9GNRH1, PRL
6naltrexone43 28 49 1212.9GNRH1, PRL
7danazol43 24 1211.9GNRH1, PRL
8metoclopramide43 49 1211.9GNRH1, PRL
9cabergoline43 28 1211.9GNRH1, PRL
10diethylstilbestrol43 28 1211.9POR, GNRH1
11cyproteroneacetate439.9GNRH1, PRL
12goserelin43 28 1211.9LHCGR, GNRH1
13bromocriptine43 28 1211.9PRL, GNRH1
14cetrorelix43 28 1211.8LHCGR, GNRH1
15fmpp439.8LHCGR, FSHR
16naloxone43 28 49 1212.8GNRH1, PRL
17ganirelix43 2810.8GNRH1, FSHB
18ptx1439.8GNRH1, FSHB
19dehydroepiandrosterone sulfate439.8PRL, GNRH1
20erythromycin43 2 49 1212.8POR, GNRH1
213beta-hydroxysteroid439.8LHCGR, POR
22dhea439.7POR, PRL
23octreotide43 59 28 1212.7GNRH1, PRL
2417-hydroxyprogesterone43 2410.7GNRH1, POR, PRL
25estrone43 28 24 1212.6GNRH1, POR, PRL
26epinephrine43 24 1211.5GNRH1, POR, PRL
27flutamide43 59 1211.5LHCGR, GNRH1, PRL
28prostaglandin f2alpha439.5LHCGR, GNRH1
29progestin439.5LHCGR, GNRH1, PRL
30clomiphene citrate439.4GNRH1, PRL, FSHB
31opiate439.3GNRH1, PRL
32androstenedione43 2410.2POR, GNRH1, PRL, FSHR
33arginine439.0LHCGR, POR, GNRH1, PRL
34guanine43 24 1210.9SRY, LHCGR, FSHR
35deoxyribonucleic acid438.9FSHB, FSHR, SRY
36buserelin43 28 1210.9FSHB, PRL, GNRH1, LHCGR
37leuprolide acetate438.9FSHB, PRL, GNRH1, LHCGR
38acth438.9FSHB, PRL, GNRH1, LHCGR
39dihydrotestosterone43 28 24 1211.8GNRH1, POR, PRL, SRY
40adenylate438.7GNRH1, FSHR, FSHB, LHCGR
41leucine438.5LHCGR, FSHR, SRY
42gnrh438.4FSHR, FSHB, PRL, GNRH1, LHCGR
43ribonucleic acid438.4LHCGR, FSHB, PRL, GNRH1, FSHR
44progesterone43 28 59 24 1212.4FSHR, FSHB, PRL, GNRH1, LHCGR
45alanine438.2FSHR, LHCGR, SRY, GNRH1, POR
46cysteine438.0POR, SRY, LHCGR, FSHB, FSHR
47estrogen438.0FSHB, LHCGR, GNRH1, POR, PRL, FSHR
48estradiol43 24 129.6PRL, FSHB, LHCGR, SRY, GNRH1, FSHR
49testosterone43 59 24 1210.2PRL, LHCGR, GNRH1, POR, FSHB, FSHR
50steroid437.2PRL, SRY, FSHR, LHCGR, GNRH1, FSHB

GO Terms for genes affiliated with Amenorrhea

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Biological processes related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1Sertoli cell proliferationGO:00600119.5FSHR, FSHB
2uterus developmentGO:00600659.4LHCGR, FSHR
3male gonad developmentGO:00085849.4LHCGR, FSHR
4regulation of osteoclast differentiationGO:00456709.4FSHR, FSHB
5female gamete generationGO:00072929.2FSHB, FSHR
6phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.1FSHR, LHCGR
7female pregnancyGO:00075659.1PRL, FSHB, GNRH1

Molecular functions related to Amenorrhea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.0FSHB, PRL, GNRH1

Products for genes affiliated with Amenorrhea

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Sources for Amenorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet