Aliases & Classifications for Amenorrhea

MalaCards integrated aliases for Amenorrhea:

Name: Amenorrhea 12 72 28 41 14 69
Absence of Menstruation 12
Amenia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13938
ICD10 32 N91.2
ICD9CM 34 626.0
MeSH 41 D000568
NCIt 46 C61443
UMLS 69 C0002453

Summaries for Amenorrhea

MalaCards based summary : Amenorrhea, also known as absence of menstruation, is related to hypogonadotropic hypogonadism 23 without anosmia and pituitary adenoma, prolactin-secreting, and has symptoms including menometrorrhagia and ovulation bleeding. An important gene associated with Amenorrhea is FSHR (Follicle Stimulating Hormone Receptor), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Calcium Carbonate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and bone, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Wikipedia : 72 Amenorrhoea is the absence of a menstrual period in a woman of reproductive age. Physiological states of... more...

Related Diseases for Amenorrhea

Diseases related to Amenorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropic hypogonadism 23 without anosmia 31.7 GNRH1 LHB
2 pituitary adenoma, prolactin-secreting 31.1 POMC PRL TRH
3 bulimia nervosa 2 31.1 CRH LEP POMC PRL
4 polycystic ovary syndrome 31.1 FSHR GNRH1 LEP PRL SHBG
5 premature ovarian failure 1 30.5 BMP15 FSHR GNRH1 NOBOX NR5A1 POF1B
6 hypogonadotropism 30.3 GNRH1 PRL
7 gonadal dysgenesis 29.6 BMP15 FSHR NR5A1 SRY
8 diabetes insipidus 29.5 CRH POMC PRL
9 hypogonadism 29.5 FSHB GNRH1 LHB LHCGR
10 endogenous depression 29.3 CRH GNRH1 TRH
11 craniopharyngioma 29.3 GNRH1 PRL TRH
12 androgen insensitivity syndrome 29.3 NR5A1 SHBG SRY
13 pituitary apoplexy 29.2 GNRH1 POMC PRL
14 hypothyroidism 29.2 LEP PRL SHBG TRH
15 acromegaly 29.2 POMC PRL TRH
16 46 xy gonadal dysgenesis 29.1 NR5A1 SHBG SRY WNT4
17 hyperprolactinemia 29.1 GNRH1 POMC PRL TRH
18 hermaphroditism 29.1 SHBG SRY WNT4
19 infertility 29.0 FSHB FSHR GNRH1 LHB LHCGR NR5A1
20 diabetes insipidus, neurohypophyseal 29.0 GNRH1 POMC PRL
21 lipoid congenital adrenal hyperplasia 28.9 NR5A1 POMC SRY
22 hyperthyroidism 28.9 LEP PRL SHBG TRH
23 empty sella syndrome 28.8 GNRH1 POMC PRL TRH
24 hyperandrogenism 28.8 GNRH1 POMC PRL SHBG WNT4
25 anovulation 28.8 BMP15 FSHB FSHR GNRH1 LEP PRL
26 ovarian disease 28.8 BMP15 FSHR GNRH1 NOBOX POF1B PRL
27 hypoadrenalism 28.7 CRH POMC SHBG
28 hypopituitarism 28.6 CRH GNRH1 POMC PRL
29 sex differentiation disease 27.5 GNRH1 LHCGR POMC PRL SHBG SRY
30 amenorrhea-galactorrhea syndrome 12.1
31 ahumada del castillo syndrome 11.2
32 aromatase deficiency 11.2
33 frasier syndrome 11.0
34 hypogonadotropic hypogonadism 24 without anosmia 11.0
35 perrault syndrome 11.0
36 ovarian dysgenesis 2 10.9
37 ovarian dysgenesis 1 10.9
38 leydig cell hypoplasia, type i 10.9
39 satoyoshi syndrome 10.9
40 leukoencephalopathy with vanishing white matter 10.9
41 premature ovarian failure 10 10.9
42 perrault syndrome 2 10.9
43 premature ovarian failure 8 10.9
44 premature ovarian failure 9 10.9
45 premature ovarian failure 11 10.9
46 blepharophimosis, ptosis, and epicanthus inversus 10.7
47 mullerian aplasia and hyperandrogenism 10.7
48 gapo syndrome 10.7
49 premature ovarian failure 2a 10.7
50 premature ovarian failure 2b 10.7

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to Amenorrhea

Symptoms & Phenotypes for Amenorrhea

UMLS symptoms related to Amenorrhea:


menometrorrhagia, ovulation bleeding

MGI Mouse Phenotypes related to Amenorrhea:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.17 BMP15 CRH FSHB FSHR GNRH1 LEP
2 growth/size/body region MP:0005378 9.96 LHCGR NOBOX NR5A1 POMC TRH CRH
3 homeostasis/metabolism MP:0005376 9.9 CRH FSHB FSHR GNRH1 LEP LHB
4 nervous system MP:0003631 9.7 CRH FSHR GNRH1 LEP LHCGR NOBOX
5 reproductive system MP:0005389 9.36 PRL WNT4 BMP15 FSHB FSHR GNRH1

Drugs & Therapeutics for Amenorrhea

Drugs for Amenorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 217)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4,Phase 3 471-34-1
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
3
Leuprolide Approved, Investigational Phase 4,Phase 2 53714-56-0 657181 3911
4
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2 797-63-7, 17489-40-6 13109
5
Tibolone Approved, Investigational Phase 4 5630-53-5
6
Metformin Approved Phase 4 657-24-9 4091 14219
7
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
8
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3,Phase 1 57-63-6 5991
9
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
10
Copper Approved, Investigational Phase 4,Phase 1 7440-50-8 27099
11
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
12
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 71-58-9
13
Menthol Approved Phase 4 2216-51-5 16666
14
Desogestrel Approved Phase 4,Phase 3 54024-22-5 40973
15
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
16
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
18
Enclomiphene Investigational Phase 4,Phase 3,Phase 2 15690-57-0
19 Anabolic Agents Phase 4,Phase 2
20 Androgen Antagonists Phase 4,Phase 2
21 Androgens Phase 4,Phase 2
22 Antacids Phase 4,Phase 3
23 Antihypertensive Agents Phase 4
24 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
25 Anti-Ulcer Agents Phase 4,Phase 3
26 Bone Density Conservation Agents Phase 4,Phase 3
27 Calcium, Dietary Phase 4,Phase 3,Phase 2
28 Contraceptive Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Estradiol 17 beta-cypionate Phase 4,Phase 3,Phase 2,Phase 1
30 Estradiol 3-benzoate Phase 4,Phase 3,Phase 2,Phase 1
31 Estradiol valerate Phase 4,Phase 3,Phase 2,Phase 1 979-32-8
32 Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2
33 Estrogens Phase 4,Phase 3,Phase 2,Phase 1
34 Fertility Agents Phase 4,Phase 3,Phase 2
35 Gastrointestinal Agents Phase 4,Phase 3
36 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
37 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
39 Micronutrients Phase 4,Phase 3,Phase 1
40 Polyestradiol phosphate Phase 4,Phase 3,Phase 2,Phase 1
41 Trace Elements Phase 4,Phase 3,Phase 1
42 Vitamins Phase 4,Phase 3
43 Clomiphene Phase 4,Phase 3,Phase 2
44 Hypoglycemic Agents Phase 4,Early Phase 1
45 Zuclomiphene Phase 4,Phase 3,Phase 2
46 Contraceptive Agents, Male Phase 4,Phase 2,Phase 3
47
Cyproterone Phase 4 2098-66-0 5284537
48 Vitamin B Complex Phase 4,Phase 3
49 insulin Phase 4,Phase 2,Early Phase 1
50 Insulin, Globin Zinc Phase 4,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 221)

# Name Status NCT ID Phase Drugs
1 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
2 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4 Metformin and FSHr
3 CavatermTM vs TCRE in Women With DUB Unknown status NCT00549159 Phase 4
4 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4 Ethinyl Estradiol + Cyproterone acetate
5 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
6 Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients Completed NCT01206153 Phase 4 metformin
7 Safety and Efficacy of PROMETRIUM® Capsules in Induction of Secretory Conversion Completed NCT00160199 Phase 4 PROMETRIUM® 300 mg;PROMETRIUM® 400 mg
8 Endometrial Ablation With Non-hysteroscopic Methods Completed NCT01173965 Phase 4
9 Acceptability and Continuation Rate of Implanon in a Brazilian Public Sector Completed NCT01392157 Phase 4
10 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
11 Effect of Hormone Replacement Therapy on Lupus Activity Completed NCT00392093 Phase 4 Conjugated equine estrogens 0.625 mg/d + MPA 5 mg/d/10d
12 Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Completed NCT01463202 Phase 4 Depot medroxyprogesterone acetate;Depot medroxyprogesterone acetate
13 Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS) Recruiting NCT02500147 Phase 4 Metformin;Placebo
14 "Stair Step Study" Recruiting NCT03309176 Phase 4 Medroxyprogesterone Acetate 10 MG
15 A Study to Compare the Menstrual Bleeding Profile Among Jaydess® and Copper Intrauterine Device (IUD) Users. COLIBRI STUDY (Copper and Levonorgestrel IUD Barcelona Research Initiative). Recruiting NCT02957292 Phase 4 Levonorgestrel (13,5 mg) intrauterine device
16 Tenofovir As Prevention Of Hepatitis b Mother-to-child Transmission Recruiting NCT02937779 Phase 4 Tenofovir disoproxil fumarate
17 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Recruiting NCT02904070 Phase 4
18 Contraceptive Pill and Hormonal Vaginal Ring in Women With Polycystic Ovary Syndrome Recruiting NCT01588873 Phase 4 oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
19 Evaluation of 4th Generation Bipolar Radiofrequency Endometrial Ablation Device Active, not recruiting NCT02449304 Phase 4
20 The Luveris In Vitro Fertilization Trial Terminated NCT00889512 Phase 4 Luveris fixed dose;Luveris increasing dose
21 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
22 Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study Unknown status NCT00746148 Phase 3
23 Reflexology's Effect on Polycystic Ovary Syndrome (PCOS) Unknown status NCT00744510 Phase 3
24 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed NCT01185782 Phase 3 Gonalef® (Follitropin alfa);Purified pituitary gonadotropin (Fertinorm-P®)
25 PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata Completed NCT01629563 Phase 3 PGL4001 5 mg;PGL4001 10 mg
26 A Study to Evaluate of the Safety and Effectiveness of Asoprisnil in Treating Women With Uterine Fibroids Completed NCT00152256 Phase 3 Asoprisnil;Asoprisnil;Placebo
27 Uterine Balloon Treatment for Heavy Period Bleeding. Completed NCT00215618 Phase 3
28 Evaluation Of Pessaries In Twin Pregnancies With A Short Cervix (25 mm) Between 20-28 WG (EPEGE) Completed NCT00502190 Phase 3
29 Endometrial Safety Study Completed NCT00522873 Phase 3 0.25mg DRSP / 0.5mg E2 (BAY86-4891);0.5mg NETA / 1.0mg E2 (Activella)
30 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
31 Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer Completed NCT00427245 Phase 3 cyclophosphamide;goserelin acetate
32 Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes Completed NCT00003782 Phase 3 cyclophosphamide;docetaxel;doxorubicin
33 The Effects of Tualang Honey on Postmenopausal Women Completed NCT01300676 Phase 2, Phase 3 Tualang honey
34 Effects of Anorexia Nervosa on Bone Mass in Adolescents Completed NCT00088153 Phase 2, Phase 3 Physiologic Estrogen/progesterone
35 Endometrial Safety Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination Completed NCT00160316 Phase 3 0.5 Mg Estradiol and 2.5 Mg Dydrogesterone
36 Maintenance Treatment With Capecitabine Versus Observation in Breast Cancer Patients Completed NCT00130533 Phase 3 Capecitabine
37 Study of Safety and Efficacy of an Oral Contraceptive Completed NCT00391807 Phase 3 Norethindrone acetate/ethinyl estradiol
38 Vasomotoric Symptoms Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination Completed NCT00251082 Phase 3 continuous combined estradiol and dydrogesterone;continuous combined estradiol and dydrogesterone;Placebo
39 Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis Completed NCT00808132 Phase 3 bazedoxifene 20 mg/ conjugated estrogens 0.45 mg;bazedoxifene 20 mg/ conjugated estrogens 0.625 mg;bazedoxifene 20 mg;conjugated estrogens 0.45 mg/ medroxyprogesterone acetate 1.5 mg;Placebo
40 Postoperative Use of Zoledronic Acid in Breast Cancer Patients After Neoadjuvant Chemotherapy Completed NCT00512993 Phase 3 Zoledronic acid
41 Comparison of Two Combination Chemotherapy Regimens in Treating Women With Breast Cancer Completed NCT00087178 Phase 3 cyclophosphamide;adriamycin;epirubicin;fluorouracil
42 Safety of Treatment of Uterine Fibroids With Asoprisnil Completed NCT00156208 Phase 3 Asoprisnil;Asoprisnil
43 A Study to Evaluate the Safety and Effectiveness of Asoprisnil in the Treatment of Uterine Fibroids Completed NCT00160381 Phase 3 Asoprisnil;Asoprisnil;Placebo
44 Study to Evaluate the Safety of Asoprisnil in the Treatment of Uterine Fibroids Completed NCT00156195 Phase 3 Asoprisnil;Asoprisnil
45 Study of Asoprisnil in the Treatment of Uterine Fibroids. Completed NCT00156156 Phase 3 Asoprisnil;Asoprisnil
46 Treatment of Uterine Fibroids With Asoprisnil(J867) Completed NCT00152269 Phase 3 Asoprisnil;Asoprisnil;Placebo
47 Risedronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy for Primary Breast Cancer Completed NCT00054418 Phase 3 risedronate sodium
48 The Effect of Post Ablation Medroxyprogesterone Acetate on Endometrial Amenorrhea Rates Recruiting NCT02449161 Phase 3 MPA;placebo
49 Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes Recruiting NCT00946192 Phase 3 Transdermal 17Beta-estradiol, progesterone;Ethinyl Estradiol + Desogestrel
50 Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 3) Recruiting NCT03400943 Phase 3 Vilaprisan (BAY1002670);Placebo

Search NIH Clinical Center for Amenorrhea

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: amenorrhea

Genetic Tests for Amenorrhea

Genetic tests related to Amenorrhea:

# Genetic test Affiliating Genes
1 Amenorrhea 28

Anatomical Context for Amenorrhea

MalaCards organs/tissues related to Amenorrhea:

38
Breast, Ovary, Bone, Pituitary, Testes, Brain, Monocytes

Publications for Amenorrhea

Articles related to Amenorrhea:

(show top 50) (show all 710)
# Title Authors Year
1
A novel de novo autosomal translocation 46, XX, t (5; 8) in a female with primary amenorrhea. ( 29306565 )
2018
2
Cytogenetic analysis of patients with primary amenorrhea in Eastern India. ( 29022424 )
2018
3
Risk of ovarian function recovery should be considered when switching from treatment with adjuvant tamoxifen to aromatase inhibitor therapy in women with chemotherapy-induced amenorrhea. ( 29155450 )
2018
4
Heightened cortisol response to exercise challenge in women with functional hypothalamic amenorrhea. ( 29170001 )
2018
5
Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea. ( 29403550 )
2018
6
Knowledge and Opinions of Postpartum Mothers About the Lactational Amenorrhea Method: The Turkish Experience. ( 29131679 )
2018
7
Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline. ( 28368518 )
2017
8
Cytochrome P450 Oxidoreductase Deficiency: Novel Cause of Ambiguity with Primary Amenorrhea. ( 28459039 )
2017
9
Bone metabolism in anorexia nervosa and hypothalamic amenorrhea. ( 29107598 )
2017
10
Features of polycystic ovary syndrome (PCOS) in women with functional hypothalamic amenorrhea (FHA) may be reversible with recovery of menstrual function. ( 29073797 )
2017
11
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
12
Predictors of menstruation restoration during metformin administration for treatment of antipsychotic drug-induced amenorrhea: A post hoc analysis. ( 28292552 )
2017
13
Secondary amenorrhea: Diagnostic approach and treatment considerations. ( 28832422 )
2017
14
Partial Hydatiform Mole Associated With a Pregnancy at 22 Weeks of Amenorrhea. ( 28286033 )
2017
15
Amenorrhea rates and predictors during 1 year of levonorgestrel 52 mg intrauterine system use. ( 29038072 )
2017
16
Induction and Maintenance of Amenorrhea in Transmasculine and Nonbinary Adolescents. ( 29142910 )
2017
17
Nomenclature of primary amenorrhea: A proposal document of the Japan Society of Obstetrics and Gynecology committee for the redefinition of primary amenorrhea. ( 28833893 )
2017
18
Risperidone-Induced Amenorrhea in Floridly Psychotic Female. ( 29152440 )
2017
19
Primary Amenorrhea and Endometriosis Secondary to an Unusual MA1llerian Anomaly. ( 28461177 )
2017
20
Spectrum of MRI Appearance of Mayer-Rokitansky-Kuster-Hauser (MRKH) Syndrome in Primary Amenorrhea Patients. ( 28893003 )
2017
21
Amenorrhea, Secondary ( 28613709 )
2017
22
Modulatory effects of l-carnitine plus l-acetyl-carnitine on neuroendocrine control of hypothalamic functions in functional hypothalamic amenorrhea (FHA). ( 28573875 )
2017
23
A Case of Primary Amenorrhea with Swyer Syndrome. ( 29430160 )
2017
24
Serum kisspeptin concentrations are negatively correlated with body mass index in adolescents with anorexia nervosa and amenorrhea. ( 28500826 )
2017
25
Balanced Reciprocal Translocation t(X;1) in a Girl with Tall Stature and Primary Amenorrhea. ( 28360449 )
2017
26
Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea. ( 29264460 )
2017
27
The induction of ovulation by pulsatile administration of GnRH: an appropriate method in hypothalamic amenorrhea. ( 28277105 )
2017
28
Plasma kisspeptin levels in lactational amenorrhea. ( 28490208 )
2017
29
Utility of complete blood count parameters to detect premature ovarian insufficiency in cases with oligomenorrhea/amenorrhea. ( 29243847 )
2017
30
Hypothalamic Amenorrhea and the Long-Term Health Consequences. ( 28658709 )
2017
31
Higher prevalence of clinical cardiovascular comorbidities in postmenopausal women with self-reported premenopausal hirsutism and/or oligo-amenorrhea. ( 28959377 )
2017
32
Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency. ( 28485330 )
2017
33
Amenorrhea after chemoembolization and suction curettage of caesarean scar pregnancy. ( 29303219 )
2017
34
Amenorrhea during thalidomide treatment: An unusual cause of ovarian failure? ( 28396134 )
2017
35
Presentation of Placental Site Trophoblastic Tumor with Amenorrhea. ( 28401076 )
2017
36
Treatments to Prevent Bone Loss in Functional Hypothalamic Amenorrhea: A Systematic Review and Meta-Analysis. ( 29264505 )
2017
37
Short-term estriol administration modulates hypothalamo-pituitary function in patients with functional hypothalamic amenorrhea (FHA). ( 26634769 )
2016
38
Prognostic Effects of Adjuvant Chemotherapy-Induced Amenorrhea and Subsequent Resumption of Menstruation for Premenopausal Breast Cancer Patients. ( 27057900 )
2016
39
Primary amenorrhea after bone marrow transplantation and adjuvant chemotherapy misdiagnosed as disorder of sex development: A case report. ( 27858857 )
2016
40
Risk of chemotherapy-induced amenorrhea in patients with breast cancer: a systematic review and meta-analysis. ( 27105082 )
2016
41
Patients with secondary amenorrhea due to tuberculosis endometritis towards the induced anti-tuberculosis drug category 1. ( 27642459 )
2016
42
Progestin-Induced Amenorrhea May Not Prevent the Progression of Colorectal Endometriosis. ( 27329546 )
2016
43
Increased anti-Mullerian hormone levels and ovarian size in a subgroup of women with functional hypothalamic amenorrhea: further identification of the link between polycystic ovary syndrome and functional hypothalamic amenorrhea. ( 26767792 )
2016
44
Menses resumption after cancer treatment-induced amenorrhea occurs early or not at all. ( 26658130 )
2016
45
Pathogenic Features of Dysuria in Young Women with Secondary Amenorrhea Caused by Body Weight Loss. ( 27909963 )
2016
46
The physiology of functional hypothalamic amenorrhea associated with energy deficiency in exercising women and in women with anorexia nervosa. ( 26953710 )
2016
47
Spontaneous intermittent MRI changes of a pituitary stalk lesion causing diabetes insipidus and amenorrhea. ( 27655292 )
2016
48
Novel homozygous nonsense mutations in the luteinizing hormone receptor (LHCGR) gene associated with 46,XY primary amenorrhea. ( 27016457 )
2016
49
Does polycystic ovarian morphology influence the response to treatment with pulsatile GnRH in functional hypothalamic amenorrhea? ( 27129705 )
2016
50
Anti-Mullerian hormone levels do not predict response to pulsatile GnRH in women with hypothalamic amenorrhea. ( 26984343 )
2016

Variations for Amenorrhea

Expression for Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for Amenorrhea

Pathways related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 CRH FSHB FSHR GNRH1 LEP LHB
2
Show member pathways
13.26 CRH FSHB FSHR GNRH1 LEP LHB
3
Show member pathways
12.85 FSHB FSHR LHB LHCGR NR5A1 POMC
4
Show member pathways
12.23 LEP LHB LHCGR PRL
5
Show member pathways
11.97 FSHB LEP LHB POMC
6 11.8 CRH FSHB FSHR LHB LHCGR POMC
7 11.05 FSHR LHCGR NR5A1
8 11.05 BMP15 FSHB FSHR LHB LHCGR
9
Show member pathways
10.97 LEP POMC TRH
10 10.89 FSHB FSHR
11 10.75 GNRH1 SHBG
12 10.28 CRH POMC
13 10.14 FSHB FSHR GNRH1 LHB LHCGR

GO Terms for Amenorrhea

Cellular components related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 BMP15 CRH FSHB GNRH1 LEP LHB
2 extracellular region GO:0005576 9.36 BMP15 CRH FSHB GNRH1 LEP LHB

Biological processes related to Amenorrhea according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.85 FSHB GNRH1 LHB NR5A1 POMC TRH
2 response to ethanol GO:0045471 9.84 CRH GNRH1 LEP TRH
3 male gonad development GO:0008584 9.72 FSHR LHB LHCGR NR5A1 WNT4
4 female gonad development GO:0008585 9.7 FSHR NR5A1 WNT4
5 peptide hormone processing GO:0016486 9.67 FSHB LHB POMC
6 female gamete generation GO:0007292 9.65 BMP15 FSHB FSHR
7 sex differentiation GO:0007548 9.63 SRY WNT4
8 positive regulation of JAK-STAT cascade GO:0046427 9.63 LEP PRL
9 adrenal gland development GO:0030325 9.63 CRH NR5A1 WNT4
10 response to corticosterone GO:0051412 9.62 CRH TRH
11 positive regulation of cAMP-mediated signaling GO:0043950 9.62 CRH LHCGR
12 positive regulation of adenylate cyclase activity GO:0045762 9.61 FSHR LHCGR
13 male sex determination GO:0030238 9.61 GNRH1 SRY
14 regulation of osteoclast differentiation GO:0045670 9.61 FSHB FSHR LHCGR
15 regulation of receptor activity GO:0010469 9.61 BMP15 FSHB GNRH1 LEP LHB POMC
16 positive regulation of male gonad development GO:2000020 9.6 NR5A1 SRY
17 regulation of steroid biosynthetic process GO:0050810 9.59 LEP NR5A1
18 Sertoli cell proliferation GO:0060011 9.58 FSHB FSHR
19 progesterone biosynthetic process GO:0006701 9.58 FSHB LHB
20 hormone metabolic process GO:0042445 9.58 LEP NR5A1 WNT4
21 primary ovarian follicle growth GO:0001545 9.56 FSHR LHCGR
22 negative regulation of glucagon secretion GO:0070093 9.55 CRH LEP
23 female pregnancy GO:0007565 9.55 CRH FSHB GNRH1 LEP PRL
24 follicle-stimulating hormone signaling pathway GO:0042699 9.43 FSHB FSHR LHCGR
25 hormone-mediated signaling pathway GO:0009755 9.1 FSHB FSHR LHB LHCGR NR5A1 TRH
26 signal transduction GO:0007165 10.22 CRH FSHB FSHR GNRH1 LEP LHB
27 G-protein coupled receptor signaling pathway GO:0007186 10.11 CRH FSHB FSHR GNRH1 LHB LHCGR

Molecular functions related to Amenorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.55 CRH LEP LHB POMC WNT4
2 G-protein coupled peptide receptor activity GO:0008528 9.32 FSHR LHCGR
3 protein-hormone receptor activity GO:0016500 9.26 FSHR LHCGR
4 hormone activity GO:0005179 9.23 CRH FSHB GNRH1 LEP LHB POMC
5 follicle-stimulating hormone receptor activity GO:0004963 8.96 FSHR LHCGR

Sources for Amenorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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