MCID: AMN001
MIFTS: 57

Amenorrhea malady

Reproductive diseases category

Summaries for Amenorrhea

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66Wikipedia, 34MalaCards
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Wikipedia:66 Amenorrhoea (BE), amenorrhea (AmE), or amenorrh?a, is the absence of a menstrual period in a woman of... more...

MalaCards: Amenorrhea, also known as absence of menstruation, is related to breast cancer and anovulation. An important gene associated with Amenorrhea is POF1B (premature ovarian failure, 1B), and among its related pathways are Ovarian Infertility Genes and Transcription CREM signaling in testis. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds nilutamide and estradiol benzoate have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and pituitary, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Amenorrhea

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9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

amenorrhea 9 11 63
absence of menstruation 9
amenorrhoea nos 9
amenorrhea nos 9
amenorrhoea 9
amenia 9


External Ids:

Disease Ontology9 DOID:13938
NCIt41 C61443
MeSH36 D000568
ICD9CM28 626.0

Related Diseases for Amenorrhea

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18GeneCards, 19GeneDecks
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Diseases related to Amenorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.7LHCGR, GNRH1, POR, PRL
2anovulation30.5GNRH1, PRL, FSHR
3hyperprolactinemia30.5GNRH1, PRL
4hypogonadotropism30.4GNRH1, PRL
5polycystic ovary syndrome30.3FSHR, PRL, GNRH1, LHCGR
6hyperandrogenism30.3FSHR, PRL, GNRH1, LHCGR
7ovarian disease30.3GNRH1, PRL, FSHR
8premature ovarian failure30.1FSHR, POF1B, GNRH1
9turner syndrome30.1GNRH1
10pituitary apoplexy30.1GNRH1, PRL
11adenoma30.1LHCGR, GNRH1, POR, PRL, FSHB, FSHR
12hypothalamic disease30.0GNRH1, PRL
13leydig cell tumor30.0GNRH1, LHCGR
14infertility30.0LHCGR, GNRH1, PRL, FSHB, FSHR, SRY
15hypothyroidism30.0GNRH1, PRL, FSHR
16congenital adrenal hyperplasia30.0GNRH1, POR, SRY
17short stature30.0GNRH1, PRL, SRY
18cushing's syndrome29.9PRL
19swyer syndrome29.9SRY
20hypogonadism29.8LHCGR, GNRH1, PRL, FSHB, FSHR
21hypopituitarism29.8GNRH1, PRL
22prolactinoma29.8PRL, GNRH1
23hypoglycemia29.8PRL, GNRH1
24hyperthyroidism29.8FSHR, PRL
25precocious puberty29.7LHCGR, GNRH1, PRL, FSHR
26pituitary tumors29.7GNRH1, PRL, FSHB, FSHR
27anorexia nervosa10.5
28osteoporosis10.3
29eating disorder10.2
30gonadal dysgenesis10.2
31calloso-genital dysplasia10.2
32blindness10.2
33systemic lupus erythematosus10.1
34adrenal adenoma10.1
35lupus erythematosus10.1
36asherman's syndrome10.1
37satoyoshi syndrome10.1
38vaginal atresia10.1
39brain disease10.1
40mccune albright syndrome10.1GNRH1
41prostatic hypertrophy10.1GNRH1
42diabetes insipidus10.1
43acanthosis nigricans10.1
44empty sella syndrome10.1
45multiple sclerosis10.1
46ahumada del castillo syndrome10.1
47forbes albright syndrome10.1
48ovarian dysgenesis 110.1
49mental retardation10.1
50neurosarcoidosis10.1

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to amenorrhea

Symptoms for Amenorrhea

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Drugs & Therapeutics for Amenorrhea

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Amenorrhea

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Anatomical Context for Amenorrhea

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34MalaCards
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MalaCards organs/tissues related to Amenorrhea:

34
Breast, Bone, Pituitary, Ovary, Testes, Spinal cord, Endothelial, Thyroid, Cortex, Cervix, Myeloid, Liver, Heart, Uterus, Brain, Adrenal cortex

Animal Models for Amenorrhea or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Amenorrhea:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6FSHR, FSHB, PRL, POR, GNRH1, LHCGR
2MP:00053796.8LHCGR, GNRH1, PRL, FSHB, FSHR, SRY
3MP:00053896.6SRY, LHCGR, GNRH1, POR, PRL, FSHB

Publications for Amenorrhea

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Sources:
53PubMed
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Articles related to Amenorrhea:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Emergency contraceptive pills as a backup for lactational amenorrhea method (LAM) of contraception: a randomized controlled trial. (22935323)
2013
2
Using an algorithmic approach to secondary amenorrhea: Avoiding diagnostic error. (23588065)
2013
3
Frequency and the type of chromosomal abnormalities in patients with primary amenorrhea in northeast of iran. (24250944)
2013
4
Amenorrhea in women treated with thalidomide: report of two cases and literature review. (22161965)
2013
5
Heart rate variability in adolescents with functional hypothalamic amenorrhea and anorexia nervosa. (24359810)
2013
6
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. (22353374)
2012
7
Incidence of chemotherapy-induced amenorrhea in premenopausal patients with breast cancer following adjuvant anthracycline and taxane. (21394515)
2011
8
Taxane-based regimens as a risk factor for chemotherapy-induced amenorrhea. (21037487)
2011
9
Unexplained amenorrhea in a patient taking methotrexate for the treatment of rheumatoid arthritis. (19916871)
2010
10
Amenorrhea and "man hands". (20303484)
2010
11
Influence of ghrelin and adipocytokines on bone mineral density in adolescent female athletes with amenorrhea and eumenorrheic athletes. (20956863)
2010
12
Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B-producing thecoma and insights into the influence of inhibin B on LH. (20334861)
2010
13
Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea. (20237833)
2010
14
Clinical practice. Functional hypothalamic amenorrhea. (20660404)
2010
15
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. (19129711)
2009
16
Bone Health and Falls: Fracture Risk in Breast Cancer Survivors With Chemotherapy-Induced Amenorrhea. (19596649)
2009
17
Secondary amenorrhea with low serum luteinizing hormone and follicle-stimulating hormone caused by an inhibin A- and inhibin B-producing granulosa cell tumor. (19346197)
2009
18
Absence of endometrium as a cause of primary amenorrhea. (17531232)
2008
19
Stress-associated or functional hypothalamic amenorrhea in the adolescent. (18574223)
2008
20
Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and Muellerian duct abnormalities: a French collaborative study. (18182450)
2008
21
Functional hypothalamic amenorrhea: current view on neuroendocrine aberrations. (18224538)
2008
22
Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea. (17959613)
2008
23
Secondary amenorrhea resulting from traumatic separation of the cervix from the uterine corpus. (17666653)
2007
24
Serum anti-mA1llerian hormone levels in women with secondary amenorrhea. (16616745)
2006
25
Current evaluation of amenorrhea. (17055812)
2006
26
Primary amenorrhea. Varied etiology. (16155669)
2005
27
Chemotherapy for acute myeloid leukemias with cytosine arabinoside, daunorubicin, etoposide, and mitoxantrone may cause permanent oligoasthenozoospermia or amenorrhea in middle-aged patients. (16151584)
2005
28
Recombinant human leptin in women with hypothalamic amenorrhea. (15564554)
2004
29
Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. (12749436)
2003
30
Treatment of functional hypothalamic amenorrhea with hypnotherapy. (14556821)
2003
31
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
32
A complex mosaicism 45,X/46,X,del(Xq)/46,X,idic(Xq) in a patient with secondary amenorrhea. (12381444)
2002
33
A review of the female athlete triad (amenorrhea, osteoporosis and disordered eating). (12467202)
2002
34
Meeting the needs of young women with secondary amenorrhea and spontaneous premature ovarian failure. (11978278)
2002
35
Breastfeeding, amenorrhea and contraceptive practice among postpartum women in Zibo, China. (12428929)
2002
36
Lactational amenorrhea/anovulation and some of their determinants: a comparison of well-nourished and undernourished women. (11476779)
2001
37
A longitudinal study of disturbances of the hypothalamic-pituitary-adrenal axis in women with progestin-negative functional hypothalamic amenorrhea. (11591409)
2001
38
Understanding the female athlete triad: eating disorders, amenorrhea, and osteoporosis. (10544368)
1999
39
Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea. (9768680)
1998
40
Identification of allelic variants in the follicle-stimulating hormone receptor genes of females with or without hypergonadotropic amenorrhea. (9696229)
1998
41
Evaluation and management of amenorrhea. (9413300)
1997
42
Clinical syndromes of primary amenorrhea. (9238273)
1997
43
An inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46,XX female. (8923827)
1996
44
Hypothalamic amenorrhea: evidence for a central derangement of hypothalamic-pituitary-adrenal cortex axis activity. (8384575)
1993
45
Lynestrenol induced therapeutic amenorrhea: effects of dose reduction on serum sex-hormones and lipids. (1317638)
1992
46
Ten-year follow-up of patients with secondary amenorrhea and normal prolactin. (2048615)
1991
47
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 22-1988. A 13-year-old girl with secondary amenorrhea, obesity, acanthosis nigricans, and hirsutism. (3367952)
1988
48
Amenorrhea associated with carotenemia. (6876328)
1983
49
46, XY gonadal dysgenesis with secondary amenorrhea, virilization, and bilateral gonadoblastomas. (572994)
1979
50
A 15-year-old female with amenorrhea, abdominal distention, and elevated human chorionic gonadotropin: pregnancy, right? Not so fasta8 (23034492)
.

Variations for Amenorrhea

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Expression for genes affiliated with Amenorrhea

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for genes affiliated with Amenorrhea

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 31KEGG
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Pathways related to Amenorrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4FSHR, LHCGR
29.3FSHB, FSHR
39.3FSHR, FSHB
48.8LHCGR, FSHB, FSHR
5
Show member pathways
8.8FSHR, FSHB, LHCGR
68.8FSHR, FSHB, LHCGR
78.4FSHR, FSHB, GNRH1, LHCGR
8
Show member pathways
7.9LHCGR, GNRH1, PRL, FSHB, FSHR
9
Show member pathways
7.9FSHR, FSHB, PRL, GNRH1, LHCGR

Compounds for genes affiliated with Amenorrhea

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Amenorrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1nilutamide46 62 30 1213.0GNRH1, POR
2estradiol benzoate4610.0GNRH1, PRL
3leuprolide46 62 30 1213.0PRL, GNRH1
4mhpg4610.0GNRH1, PRL
5toremifene46 1210.9PRL, GNRH1
6naltrexone46 30 52 1212.9PRL, GNRH1
7metoclopramide46 52 1211.9GNRH1, PRL
8cabergoline46 30 1211.9GNRH1, PRL
9danazol46 25 1211.9GNRH1, PRL
10diethylstilbestrol46 30 1211.9GNRH1, POR
11cyproteroneacetate469.9PRL, GNRH1
12goserelin46 30 1211.9LHCGR, GNRH1
13bromocriptine46 30 1211.9GNRH1, PRL
14cetrorelix46 30 1211.8LHCGR, GNRH1
15fmpp469.8LHCGR, FSHR
16naloxone46 30 52 1212.8GNRH1, PRL
17ganirelix46 3010.8FSHB, GNRH1
18ptx1469.8GNRH1, FSHB
19dehydroepiandrosterone sulfate469.8PRL, GNRH1
20erythromycin46 3 52 1212.8POR, GNRH1
213beta-hydroxysteroid469.8LHCGR, POR
22dhea469.7PRL, POR
23octreotide46 62 30 1212.7GNRH1, PRL
2417-hydroxyprogesterone46 2510.7GNRH1, POR, PRL
25estrone46 30 25 1212.6PRL, POR, GNRH1
26epinephrine46 25 1211.5GNRH1, POR, PRL
27flutamide46 62 1211.5PRL, GNRH1, LHCGR
28prostaglandin f2alpha469.5GNRH1, LHCGR
29progestin469.5LHCGR, GNRH1, PRL
30clomiphene citrate469.4FSHB, PRL, GNRH1
31opiate469.3PRL, GNRH1
32androstenedione46 2510.2GNRH1, POR, PRL, FSHR
33arginine469.0LHCGR, GNRH1, POR, PRL
34guanine46 25 1210.9SRY, FSHR, LHCGR
35deoxyribonucleic acid468.9SRY, FSHR, FSHB
36leuprolide acetate468.9LHCGR, GNRH1, PRL, FSHB
37buserelin46 30 1210.9LHCGR, GNRH1, PRL, FSHB
38acth468.9LHCGR, GNRH1, PRL, FSHB
39dihydrotestosterone46 30 25 1211.8GNRH1, POR, PRL, SRY
40adenylate468.7LHCGR, GNRH1, FSHB, FSHR
41leucine468.5LHCGR, FSHR, SRY
42gnrh468.4LHCGR, GNRH1, PRL, FSHB, FSHR
43ribonucleic acid468.4FSHR, FSHB, PRL, GNRH1, LHCGR
44progesterone46 30 62 25 1212.4LHCGR, GNRH1, PRL, FSHB, FSHR
45alanine468.2LHCGR, GNRH1, POR, FSHR, SRY
46cysteine468.0SRY, FSHR, FSHB, POR, LHCGR
47estrogen468.0LHCGR, GNRH1, POR, PRL, FSHB, FSHR
48estradiol46 25 129.6LHCGR, GNRH1, PRL, FSHB, FSHR, SRY
49testosterone46 62 25 1210.2SRY, LHCGR, GNRH1, POR, PRL, FSHB
50steroid467.2LHCGR, GNRH1, POR, PRL, FSHB, FSHR

GO Terms for genes affiliated with Amenorrhea

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17Gene Ontology
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Biological processes related to Amenorrhea according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.5LHCGR, FSHR
2Sertoli cell proliferationGO:0600119.5FSHR, FSHB
3male gonad developmentGO:0085849.4FSHR, LHCGR
4regulation of osteoclast differentiationGO:0456709.3FSHB, FSHR
5female gamete generationGO:0072929.2FSHR, FSHB
6phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.1FSHR, LHCGR
7female pregnancyGO:0075659.1FSHB, PRL, GNRH1

Molecular functions related to Amenorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.0FSHB, PRL, GNRH1

Products for genes affiliated with Amenorrhea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amenorrhea

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet