MCID: AMN001
MIFTS: 63

Amenorrhea malady

Summaries for Amenorrhea

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63Wikipedia, 32MalaCards
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Wikipedia:63 Amenorrhoea (BE), amenorrhea (AmE), or amenorrhœa, is the absence of a menstrual period in a woman of... more...

MalaCards: Amenorrhea, also known as absence of menstruation, is related to breast cancer and anorexia nervosa. An important gene associated with Amenorrhea is POF1B (premature ovarian failure, 1B), and among its related pathways are Endogenous sterols and FSH signaling pathway. The drugs bromocriptine and hydroxyprogesterone and the compounds estrogen and buserelin have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and pituitary, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Amenorrhea

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

amenorrhea 8 10 60
absence of menstruation 8
amenorrhoea nos 8
amenorrhea nos 8
amenorrhoea 8
amenia 8


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Disease Ontology8 DOID:13938
MeSH34 D000568
ICD9CM27 626.0
NCIt39 C61443

Related Diseases for Amenorrhea

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17GeneCards, 18GeneDecks
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Diseases related to Amenorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.8LHCGR, GNRH1, AR, PRL, NR5A1, POR
2anorexia nervosa30.7CRH, PRL, LEP
3eating disorder30.6LEP
4anovulation30.4GNRH1, PRL, FSHR, LEP, CYP19A1
5hyperprolactinemia30.3PRL, CRH, GNRH1
6hyperandrogenism30.3CYP19A1, PRL, CRH, AR, GNRH1, LHCGR
7polycystic ovary syndrome30.3FSHB, FSHR, LEP, CYP17A1, CYP19A1, POR
8gonadal dysgenesis30.3SRY, NR5A1
9hypogonadotropism30.2PRL, GNRH1
10ovarian disease30.2FSHR, PRL, GNRH1
11adenoma30.2LHCGR, GNRH1, CRH, PRL, NR5A1, POR
12infertility30.2GNRH1, LHCGR, BMP15, AR, PRL, LGR6
13systemic lupus erythematosus30.1PRL
14hypothalamic disease30.1PRL, CRH, GNRH1
15adrenal adenoma30.1CRH, CYP19A1, CYP17A1
16diabetes insipidus30.0PRL
17premature ovarian failure30.0LGR6, FSHR, PRL, BMP15, GNRH1
18uterine fibroid30.0GNRH1
19turner syndrome29.9GNRH1
20endogenous depression29.9CRH
21androgen insensitivity syndrome29.9SRY, AR
22congenital adrenal hyperplasia29.9NR5A1, POR
23sertoli cell tumor29.9CYP19A1, AR
24leydig cell tumor29.9LHCGR, GNRH1, NR5A1, CYP19A1, CYP17A1
25hypothyroidism29.9GNRH1, PRL, LEP, FSHR
26pituitary apoplexy29.9GNRH1, PRL
27obesity29.9AR, CRH, NR5A1, LEP, FSHR
28ovarian cancer29.9LHCGR, GNRH1, AR, POR, CYP19A1, CYP17A1
29hypogonadism29.9LGR6, FSHB, FSHR, LEP, CYP19A1, NR5A1
30hermaphroditism29.7SRY
31diabetes mellitus29.7LEP
32leiomyoma29.7CYP17A1, CYP19A1, GNRH1
33adenocarcinoma29.7AR, NR5A1, FSHR
34hypopituitarism29.7LEP, PRL, CRH, GNRH1
35sexual disorder29.7PRL, GNRH1
36hypertension29.7LEP, CYP17A1, CRH
37hyperthyroidism29.7FSHR, LEP, PRL
38acth-secreting pituitary adenoma29.7PRL, CRH
39hypoglycemia29.7GNRH1, CRH, PRL
40cushing's syndrome29.7LHCGR, GNRH1, CRH, PRL, POR, CYP17A1
41pituitary adenoma29.7GNRH1, CRH, PRL, NR5A1, LEP, FSHR
42prolactinoma29.7GNRH1, PRL, NR5A1
43aromatase deficiency29.7CYP19A1
44osteoporosis10.3
45calloso-genital dysplasia10.2
46lupus erythematosus10.1
47satoyoshi syndrome10.1
48brain disease10.1
49acanthosis nigricans10.0
50empty sella syndrome10.0

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to amenorrhea

Clinical Features for Amenorrhea

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Drugs & Therapeutics for Amenorrhea

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Amenorrhea

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Anatomical Context for Amenorrhea

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32MalaCards
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MalaCards organs/tissues related to Amenorrhea:

32
Breast, Bone, Pituitary, Ovary, Testes, Endothelial, Thyroid, Uterus, Spinal cord, Heart, Brain, Myeloid, Liver, Cervix, Cortex, Adrenal cortex

Animal Models for Amenorrhea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Amenorrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2GNRH1, AR, CRH, PRL, CYP19A1, LEP
2MP:000537010.2GNRH1, AR, PRL, POR, CYP19A1, LEP
3MP:000538610.2LHCGR, AR, CRH, PRL, NR5A1, POR
4MP:000287310.2LGR6, CYP19A1, POF1B, NR5A1, CRH, AR
5MP:000538410.2AR, GNRH1, LHCGR, LHB, CRH, NR5A1
6MP:000537610.1LHB, LHCGR, GNRH1, AR, CRH, PRL
7MP:000538910.0SRY, LHB, LHCGR, GNRH1, PSMC3IP, BMP15
8MP:000363110.0GNRH1, AR, CRH, PRL, NR5A1, POR
9MP:000537910.0AR, BMP15, PSMC3IP, GNRH1, LHCGR, LHB
10MP:000537510.0LHCGR, AR, CYP19A1, LEP, FSHR

Publications for Amenorrhea

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50PubMed
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Articles related to Amenorrhea:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Emergency contraceptive pills as a backup for lactational amenorrhea method (LAM) of contraception: a randomized controlled trial. (22935323)
2013
2
Amenorrhea in women treated with thalidomide: report of two cases and literature review. (22161965)
2013
3
Etiological Evaluation of Adolescents with Primary Amenorrhea. (24178309)
2013
4
Chemotherapy-induced amenorrhea, menopause-specific quality of life, and endocrine profiles in premenopausal women with breast cancer who received adjuvant anthracycline-based chemotherapy: a prospective cohort study. (23842722)
2013
5
Decreased plasma concentrations of brain-derived neurotrophic factor (BDNF) in patients with functional hypothalamic amenorrhea. (23844985)
2013
6
Function and innervation of the locus ceruleus in a macaque model of Functional Hypothalamic Amenorrhea. (23069677)
2013
7
Embolization of angiographically visible type I and II utero-ovarian anastomoses during uterine artery embolization for fibroid tumors: impact on symptom recurrence and permanent amenorrhea. (23871695)
2013
8
Mosaic triple X syndrome in a female with primary amenorrhea. (23162306)
2012
9
Optimizing bone health in anorexia nervosa and hypothalamic amenorrhea: new trials and tribulations. (22300837)
2012
10
Skeletal status and body composition in young women with functional hypothalamic amenorrhea. (21957879)
2012
11
Thyroid carcinoma and primary amenorrhea due to Mayer-Rokitansky-KA1ster-Hauser syndrome: a case report. (23130807)
2012
12
Bone mineral density in girls with functional hypothalamic amenorrhea subjected to estroprogestagen treatment--a 4-year prospective study. (21500996)
2011
13
Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial. (20943753)
2011
14
A case of resolution of amenorrhea after CPAP therapy for obstructive sleep apnea. (19596606)
2010
15
Clinical inquiries. What's the best way to manage athletes with amenorrhea? (19006626)
2008
16
A pilot study of predictive markers of chemotherapy-related amenorrhea among premenopausal women with early stage breast cancer. (18317970)
2008
17
Fecundability and spontaneous abortions in women with self-reported oligo-amenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. (18544581)
2008
18
Short-term response of bone turnover to low-dose oral contraceptives in exercising women with hypothalamic amenorrhea. (18226672)
2008
19
The complex relationship between hypothalamic amenorrhea and polycystic ovary syndrome. (18230664)
2008
20
Celiac disease as a rare cause of primary amenorrhea: a case report. (17583254)
2007
21
Primary amenorrhea in a 46,XY adolescent girl with partial gonadal dysgenesis: identification of a new SRY gene mutation. (17493621)
2007
22
Adjuvant chemotherapy followed by goserelin compared with either modality alone: the impact on amenorrhea, hot flashes, and quality of life in premenopausal patients--the International Breast Cancer Study Group Trial VIII. (17159194)
2007
23
Risk factors for amenorrhea in juvenile systemic lupus erythematosus (JSLE): a Brazilian multicentre cohort study. (17670855)
2007
24
Copper intrauterine devices in the management of secondary amenorrhea. (16781716)
2006
25
Amenorrhea due to partial uterine necrosis after uterine artery embolization for control of refractory postpartum hemorrhage. (16024157)
2006
26
Primary amenorrhea in a teenager. (16449131)
2006
27
Effects of an oral contraceptive (norgestimate/ethinyl estradiol) on bone mineral density in women with hypothalamic amenorrhea and osteopenia: an open-label extension of a double-blind, placebo-controlled study. (16102557)
2005
28
Recombinant human leptin in women with hypothalamic amenorrhea. (15342807)
2004
29
Effects of a triphasic combination oral contraceptive containing norgestimate/ethinyl estradiol on biochemical markers of bone metabolism in young women with osteopenia secondary to hypothalamic amenorrhea. (12915650)
2003
30
How reliably does 12-month amenorrhea define final menstrual period? Data from a longitudinal study. (11974565)
2002
31
Long-term follow-up of functional hypothalamic amenorrhea and prognostic factors. (11836275)
2002
32
Lactational amenorrhea/anovulation and some of their determinants: a comparison of well-nourished and undernourished women. (11476779)
2001
33
A brief review of the effects of chronic hydrocephalus on the gonadotropin releasing hormone system: implications for amenorrhea and precocious puberty. (10672590)
2000
34
Cerebrospinal fluid levels of corticotropin-releasing hormone in women with functional hypothalamic amenorrhea. (10764453)
2000
35
Understanding the female athlete triad: eating disorders, amenorrhea, and osteoporosis. (10544368)
1999
36
A case study: secondary amenorrhea. (10504917)
1999
37
Herbal medicine (Shakuyaku-kanzo-to) in the treatment of risperidone-induced amenorrhea. (10440470)
1999
38
Increased serum level of inhibin causes amenorrhea in a granulosa cell tumor patient. (9512338)
1998
39
Altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea. (9418685)
1997
40
Bone mineral changes in young women with hypothalamic amenorrhea treated with oral contraceptives, medroxyprogesterone, or placebo over 12 months. (9166162)
1997
41
Low leptin levels predict amenorrhea in underweight and eating disordered females. (9246675)
1997
42
Postpartum contraception: the lactational amenorrhea method. (9678098)
1997
43
Hypothalamic amenorrhea: evidence for a central derangement of hypothalamic-pituitary-adrenal cortex axis activity. (8384575)
1993
44
Pulsatile luteinizing hormone secretion in hypothalamic amenorrhea, anorexia nervosa, and polycystic ovarian disease during naltrexone treatment. (1555686)
1992
45
The role of endogenous opiates in athletic amenorrhea. (1900478)
1991
46
The effect of peroral lynestrenol on serum lipids and lipoproteins in therapeutic amenorrhea of mentally retarded women. (2346078)
1990
47
Pituitary apoplexy complicating chronic secondary amenorrhea. (7077247)
1982
48
46, XY gonadal dysgenesis with secondary amenorrhea, virilization, and bilateral gonadoblastomas. (572994)
1979
49
Amenorrhea-galactorrhea associated with the empty-sella syndrome. (560123)
1977
50
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. (985824)
1976

Genetic Variations for Amenorrhea

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Expression for genes affiliated with Amenorrhea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for genes affiliated with Amenorrhea

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Amenorrhea

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Amenorrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8NR5A1, POR, LGR6
2buserelin44 28 1112.7LHCGR, GNRH1, PRL, CYP19A1, FSHB
3leuprolide acetate4410.7LHCGR, GNRH1, PRL, CYP19A1, FSHB
4danazol44 11 2412.7GNRH1, AR, PRL, CYP19A1
5cyproteroneacetate4410.7CYP19A1, PRL, AR, GNRH1
6clomiphene citrate4410.7GNRH1, CRH, PRL, CYP19A1, FSHB
7flutamide44 59 1112.7LHCGR, GNRH1, AR, PRL, CYP19A1
8letrozole44 49 59 1113.7AR, CYP19A1, CYP17A1, LEP
917-hydroxyprogesterone44 2411.6GNRH1, CRH, PRL, POR, CYP19A1, CYP17A1
10diethylstilbestrol44 28 1112.6GNRH1, AR, NR5A1, POR, CYP19A1, CYP17A1
11steroidal4410.6GNRH1, AR, CYP19A1, CYP17A1
123beta-hydroxysteroid4410.6LHCGR, AR, NR5A1, POR, CYP19A1, CYP17A1
13acth 1-244410.6CRH, PRL, CYP17A1
14progestin4410.6LHCGR, GNRH1, AR, PRL, CYP19A1, CYP17A1
15mifepristone44 59 28 1113.6GNRH1, AR, CRH, PRL, CYP19A1
16corticosterone44 59 2412.6LHCGR, CRH, PRL, NR5A1, CYP17A1, LEP
17dihydrotestosterone44 28 11 2413.6GNRH1, AR, PRL, POR, CYP19A1, CYP17A1
18estrone44 28 11 2413.6GNRH1, AR, PRL, NR5A1, POR, CYP19A1
19naloxone44 49 28 1113.6LEP, PRL, CRH, GNRH1
20nifedipine44 49 28 1113.6GNRH1, CRH, POR, CYP17A1, LEP
21dehydroepiandrosterone sulfate4410.6GNRH1, AR, CRH, PRL, NR5A1, CYP19A1
22epinephrine44 11 2412.6GNRH1, AR, CRH, PRL, POR, LEP
23ptx14410.6GNRH1, NR5A1, FSHB
24dhea4410.6AR, CRH, PRL, NR5A1, POR, CYP19A1
25acth4410.6LHCGR, GNRH1, CRH, PRL, NR5A1, CYP17A1
26tamoxifen44 49 28 1113.6GNRH1, AR, PRL, CYP19A1, CYP17A1, LEP
27cocaine44 1111.5LEP, PRL, CRH, AR, GNRH1
28citalopram49 44 11 2413.5CRH, PRL, CYP19A1, LEP
29ribonucleic acid4410.5LHCGR, GNRH1, CRH, PRL, NR5A1, CYP17A1
30androstenedione44 2411.5FSHR, GNRH1, AR, CRH, PRL, POR
31estradiol benzoate4410.5GNRH1, PRL, CYP19A1
3217beta-hydroxysteroid4410.5CYP17A1, CYP19A1, NR5A1, AR
33leuprolide44 59 28 1113.5GNRH1, AR, PRL
34vitamin d4410.5AR, CRH, NR5A1, POR, CYP19A1, CYP17A1
35ketoconazole44 28 11 2413.5AR, CRH, CYP19A1, CYP17A1
36adenylate4410.5LHCGR, GNRH1, AR, CRH, NR5A1, FSHR
37dexamethasone44 49 28 1113.5GNRH1, AR, CRH, PRL, POR, CYP19A1
38nilutamide44 59 28 1113.5GNRH1, AR, POR
39arginine4410.5LHCGR, GNRH1, AR, CRH, PRL, POR
40estradiol44 11 2412.4AR, CRH, PRL, NR5A1, CYP19A1, CYP17A1
4111 deoxycortisol4410.4CRH, PRL, CYP17A1
42progesterone44 59 28 11 2414.4CRH, AR, BMP15, GNRH1, LHCGR, PRL
43goserelin44 28 1112.4LHCGR, GNRH1, CYP19A1
44serine4410.3LHCGR, AR, CRH, NR5A1, POR, CYP17A1
45gnrh4410.3LHB, LHCGR, GNRH1, AR, CRH, PRL
46testosterone44 59 11 2413.3SRY, LGR6, FSHB, FSHR, LHCGR, GNRH1
47steroid4410.3LHCGR, GNRH1, AR, CRH, PRL, NR5A1
48metformin44 49 1112.3GNRH1, CYP19A1, CYP17A1, LEP
49cysteine4410.2CRH, LEP, FSHR, SRY
50prostaglandin f2alpha4410.0GNRH1, CRH, LGR6, LHCGR

GO Terms for genes affiliated with Amenorrhea

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16Gene Ontology
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Biological processes related to Amenorrhea according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of steroid hormone biosynthetic processGO:09003110.7CYP17A1, POR
2follicle-stimulating hormone signaling pathwayGO:04269910.7FSHR, FSHB
3negative regulation of glucagon secretionGO:07009310.7LEP, CRH
4female gamete generationGO:00729210.7BMP15, FSHR, FSHB
5regulation of steroid biosynthetic processGO:05081010.7LEP, NR5A1
6positive regulation of male gonad developmentGO:200002010.7SRY, NR5A1
7adrenal gland developmentGO:03032510.7CYP17A1, NR5A1, CRH
8prostate gland growthGO:06073610.6AR, CYP19A1
9progesterone biosynthetic processGO:00670110.6LHB, FSHB
10ovarian follicle developmentGO:00154110.6NOBOX, FSHB, BMP15, LHCGR
11ovulation cycleGO:04269810.6PRL, GNRH1
12female pregnancyGO:00756510.6GNRH1, CRH, PRL, LEP, FSHB
13glucocorticoid biosynthetic processGO:00670410.6CYP17A1, CRH
14parturitionGO:00756710.6CRH, PRL
15male gonad developmentGO:00858410.6SRY, FSHR, NR5A1, AR, LHCGR, LHB
16cellular response to gonadotropin stimulusGO:07137110.5CYP17A1, LHCGR
17response to ethanolGO:04547110.5GNRH1, CRH, PRL
18cell-cell signalingGO:00726710.5NR5A1, AR, GNRH1, LHB
19hormone metabolic processGO:04244510.4NR5A1, LEP
20peptide hormone processingGO:01648610.4FSHB, LHB
21response to drugGO:04249310.4CYP17A1, POR, PRL, CRH
22sex differentiationGO:00754810.3CYP17A1, AR
23sterol metabolic processGO:01612510.1CYP17A1, CYP19A1

Molecular functions related to Amenorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.2FSHB, LEP, PRL, CRH, GNRH1, LHB

Products for genes affiliated with Amenorrhea

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Sources for Amenorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet