MCID: AMN001
MIFTS: 59

Amenorrhea malady

Reproductive diseases category
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Summaries for Amenorrhea

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Wikipedia:65 Amenorrhoea (BE), amenorrhea (AmE), or amenorrh?a, is the absence of a menstrual period in a woman of... more...

MalaCards based summary: Amenorrhea, also known as absence of menstruation, is related to hypogonadotropism and hyperprolactinemia. An important gene associated with Amenorrhea is POF1B (premature ovarian failure, 1B), and among its related pathways are Ovarian Infertility Genes and Transcription CREM signaling in testis. The drugs bromocriptine and hydroxyprogesterone and the compounds nilutamide and estradiol benzoate have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and pituitary, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Amenorrhea

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Amenorrhea, Aliases & Descriptions:

Name: Amenorrhea 8 10 62
Absence of Menstruation 8 62
Amenorrhoea Nos 8
 
Amenorrhea Nos 8
Amenorrhoea 8
Amenia 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:13938
MeSH34 D000568
ICD9CM27 626.0
NCIt39 C61443

Related Diseases for Amenorrhea

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Diseases related to Amenorrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1hypogonadotropism30.7GNRH1, PRL
2hyperprolactinemia30.7GNRH1, PRL
3anovulation30.6GNRH1, PRL, FSHR
4turner syndrome30.6GNRH1
5ovarian disease30.4GNRH1, PRL, FSHR
6pituitary apoplexy30.4GNRH1, PRL
7premature ovarian failure30.3FSHR, POF1B, GNRH1
8hypothalamic disease30.3GNRH1, PRL
9breast cancer30.3LHCGR, GNRH1, POR, PRL
10swyer syndrome30.2SRY
11leydig cell tumor30.2GNRH1, LHCGR
12polycystic ovary syndrome30.2FSHR, PRL, GNRH1, LHCGR
13hyperandrogenism30.2FSHR, PRL, GNRH1, LHCGR
14hypopituitarism30.1GNRH1, PRL
15hypothyroidism30.0GNRH1, PRL, FSHR
16prolactinoma29.9PRL, GNRH1
17hypoglycemia29.9PRL, GNRH1
18congenital adrenal hyperplasia29.9GNRH1, POR, SRY
19short stature29.9GNRH1, PRL, SRY
20hyperthyroidism29.8FSHR, PRL
21precocious puberty29.5LHCGR, GNRH1, PRL, FSHR
22pituitary tumors29.5GNRH1, PRL, FSHB, FSHR
23adenoma29.4LHCGR, GNRH1, POR, PRL, FSHB, FSHR
24hypogonadism29.4LHCGR, GNRH1, PRL, FSHB, FSHR
25infertility29.1LHCGR, GNRH1, PRL, FSHB, FSHR, SRY
26anorexia nervosa10.5
27mccune albright syndrome10.4GNRH1
28prostatic hypertrophy10.4GNRH1
29cushing's syndrome10.4PRL
30osteoporosis10.3
31eating disorder10.3
32penile disease10.3GNRH1, PRL
33sexual disorder10.3GNRH1, PRL
34gonadal dysgenesis10.2
35neurogenic diabetes insipidus10.2PRL, GNRH1
36hypogonadism, hypergonadotropic10.2PRL, FSHR
37varicocele10.2PRL, GNRH1
38pituitary gland disease10.2GNRH1, PRL
39calloso-genital dysplasia10.2
40ahumada del castillo syndrome10.2
41blindness10.2
42gonadal disease10.2GNRH1, FSHR
43precocious puberty, male10.2LHCGR, FSHR
44penis agenesis10.2LHCGR, GNRH1
45leiomyomatosis10.2LHCGR, GNRH1
46systemic lupus erythematosus10.2
47adrenal adenoma10.2
48lupus erythematosus10.2
49asherman's syndrome10.2
50forbes albright syndrome10.2

Graphical network of the top 20 diseases related to Amenorrhea:



Diseases related to amenorrhea

Symptoms for Amenorrhea

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Drugs & Therapeutics for Amenorrhea

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Genetic Tests for Amenorrhea

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Anatomical Context for Amenorrhea

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MalaCards organs/tissues related to Amenorrhea:

32
Breast, Bone, Pituitary, Ovary, Testes, Endothelial, Spinal cord, Thyroid, Uterus, Brain, Cortex, Heart, Liver, Cervix, Myeloid, Adrenal cortex

Animal Models for Amenorrhea or affiliated genes

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MGI Mouse Phenotypes related to Amenorrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6FSHR, FSHB, PRL, POR, GNRH1, LHCGR
2MP:00053796.8LHCGR, GNRH1, PRL, FSHB, FSHR, SRY
3MP:00053896.6SRY, LHCGR, GNRH1, POR, PRL, FSHB

Publications for Amenorrhea

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Articles related to Amenorrhea:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Functional hypothalamic amenorrhea and its influence on women's health. (25201001)
2014
2
Emergency contraceptive pills as a backup for lactational amenorrhea method (LAM) of contraception: a randomized controlled trial. (22935323)
2013
3
Using an algorithmic approach to secondary amenorrhea: Avoiding diagnostic error. (23588065)
2013
4
Frequency and the type of chromosomal abnormalities in patients with primary amenorrhea in northeast of iran. (24250944)
2013
5
Amenorrhea in women treated with thalidomide: report of two cases and literature review. (22161965)
2013
6
Heart rate variability in adolescents with functional hypothalamic amenorrhea and anorexia nervosa. (24359810)
2013
7
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. (22353374)
2012
8
Incidence of chemotherapy-induced amenorrhea in premenopausal patients with breast cancer following adjuvant anthracycline and taxane. (21394515)
2011
9
Taxane-based regimens as a risk factor for chemotherapy-induced amenorrhea. (21037487)
2011
10
Unexplained amenorrhea in a patient taking methotrexate for the treatment of rheumatoid arthritis. (19916871)
2010
11
Amenorrhea and "man hands". (20303484)
2010
12
Influence of ghrelin and adipocytokines on bone mineral density in adolescent female athletes with amenorrhea and eumenorrheic athletes. (20956863)
2010
13
Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B-producing thecoma and insights into the influence of inhibin B on LH. (20334861)
2010
14
Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea. (20237833)
2010
15
Clinical practice. Functional hypothalamic amenorrhea. (20660404)
2010
16
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. (19129711)
2009
17
Bone Health and Falls: Fracture Risk in Breast Cancer Survivors With Chemotherapy-Induced Amenorrhea. (19596649)
2009
18
Secondary amenorrhea with low serum luteinizing hormone and follicle-stimulating hormone caused by an inhibin A- and inhibin B-producing granulosa cell tumor. (19346197)
2009
19
Absence of endometrium as a cause of primary amenorrhea. (17531232)
2008
20
Stress-associated or functional hypothalamic amenorrhea in the adolescent. (18574223)
2008
21
Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and Muellerian duct abnormalities: a French collaborative study. (18182450)
2008
22
Functional hypothalamic amenorrhea: current view on neuroendocrine aberrations. (18224538)
2008
23
Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea. (17959613)
2008
24
Secondary amenorrhea resulting from traumatic separation of the cervix from the uterine corpus. (17666653)
2007
25
Serum anti-mA1llerian hormone levels in women with secondary amenorrhea. (16616745)
2006
26
Current evaluation of amenorrhea. (17055812)
2006
27
Primary amenorrhea. Varied etiology. (16155669)
2005
28
Chemotherapy for acute myeloid leukemias with cytosine arabinoside, daunorubicin, etoposide, and mitoxantrone may cause permanent oligoasthenozoospermia or amenorrhea in middle-aged patients. (16151584)
2005
29
Secondary amenorrhea after Hodgkin's lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: a report from the German Hodgkin's Lymphoma Study Group. (16234521)
2005
30
Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. (12749436)
2003
31
Wilson disease manifested primarily as amenorrhea and accompanying thrombocytopenia. (12359384)
2002
32
A complex mosaicism 45,X/46,X,del(Xq)/46,X,idic(Xq) in a patient with secondary amenorrhea. (12381444)
2002
33
A review of the female athlete triad (amenorrhea, osteoporosis and disordered eating). (12467202)
2002
34
Meeting the needs of young women with secondary amenorrhea and spontaneous premature ovarian failure. (11978278)
2002
35
Breastfeeding, amenorrhea and contraceptive practice among postpartum women in Zibo, China. (12428929)
2002
36
Lactational amenorrhea/anovulation and some of their determinants: a comparison of well-nourished and undernourished women. (11476779)
2001
37
A longitudinal study of disturbances of the hypothalamic-pituitary-adrenal axis in women with progestin-negative functional hypothalamic amenorrhea. (11591409)
2001
38
Understanding the female athlete triad: eating disorders, amenorrhea, and osteoporosis. (10544368)
1999
39
Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea. (9768680)
1998
40
Identification of allelic variants in the follicle-stimulating hormone receptor genes of females with or without hypergonadotropic amenorrhea. (9696229)
1998
41
Evaluation and management of amenorrhea. (9413300)
1997
42
Clinical syndromes of primary amenorrhea. (9238273)
1997
43
An inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46,XX female. (8923827)
1996
44
Hypothalamic amenorrhea: evidence for a central derangement of hypothalamic-pituitary-adrenal cortex axis activity. (8384575)
1993
45
Lynestrenol induced therapeutic amenorrhea: effects of dose reduction on serum sex-hormones and lipids. (1317638)
1992
46
Ten-year follow-up of patients with secondary amenorrhea and normal prolactin. (2048615)
1991
47
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 22-1988. A 13-year-old girl with secondary amenorrhea, obesity, acanthosis nigricans, and hirsutism. (3367952)
1988
48
Amenorrhea associated with carotenemia. (6876328)
1983
49
46, XY gonadal dysgenesis with secondary amenorrhea, virilization, and bilateral gonadoblastomas. (572994)
1979
50
A 15-year-old female with amenorrhea, abdominal distention, and elevated human chorionic gonadotropin: pregnancy, right? Not so fasta8 (23034492)
.

Variations for Amenorrhea

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Expression for genes affiliated with Amenorrhea

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Expression patterns in normal tissues for genes affiliated with Amenorrhea

Search GEO for disease gene expression data for Amenorrhea.

Pathways for genes affiliated with Amenorrhea

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Pathways related to Amenorrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4FSHR, LHCGR
29.3FSHB, FSHR
39.3FSHR, FSHB
48.8LHCGR, FSHB, FSHR
5
Show member pathways
8.8FSHR, FSHB, LHCGR
68.8FSHR, FSHB, LHCGR
78.4FSHR, FSHB, GNRH1, LHCGR
8
Show member pathways
7.9LHCGR, GNRH1, PRL, FSHB, FSHR
9
Show member pathways
7.9FSHR, FSHB, PRL, GNRH1, LHCGR

Compounds for genes affiliated with Amenorrhea

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Compounds related to Amenorrhea according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1nilutamide44 61 28 1113.0GNRH1, POR
2estradiol benzoate4410.0GNRH1, PRL
3leuprolide44 61 28 1113.0PRL, GNRH1
4mhpg4410.0GNRH1, PRL
5toremifene44 1110.9PRL, GNRH1
6naltrexone44 28 50 1112.9PRL, GNRH1
7metoclopramide44 50 1111.9GNRH1, PRL
8cabergoline44 28 1111.9GNRH1, PRL
9danazol44 24 1111.9GNRH1, PRL
10diethylstilbestrol44 28 1111.9GNRH1, POR
11cyproteroneacetate449.9PRL, GNRH1
12goserelin44 28 1111.9LHCGR, GNRH1
13bromocriptine44 28 1111.9GNRH1, PRL
14cetrorelix44 28 1111.8LHCGR, GNRH1
15fmpp449.8LHCGR, FSHR
16naloxone44 28 50 1112.8GNRH1, PRL
17ganirelix44 2810.8FSHB, GNRH1
18ptx1449.8GNRH1, FSHB
19dehydroepiandrosterone sulfate449.8PRL, GNRH1
20erythromycin44 2 50 1112.8POR, GNRH1
213beta-hydroxysteroid449.8LHCGR, POR
22dhea449.7PRL, POR
23octreotide44 61 28 1112.7GNRH1, PRL
2417-hydroxyprogesterone44 2410.7GNRH1, POR, PRL
25estrone44 28 24 1112.6PRL, POR, GNRH1
26epinephrine44 24 1111.5GNRH1, POR, PRL
27flutamide44 61 1111.5PRL, GNRH1, LHCGR
28prostaglandin f2alpha449.5GNRH1, LHCGR
29progestin449.5LHCGR, GNRH1, PRL
30clomiphene citrate449.4FSHB, PRL, GNRH1
31opiate449.3PRL, GNRH1
32androstenedione44 2410.2GNRH1, POR, PRL, FSHR
33arginine449.0LHCGR, GNRH1, POR, PRL
34guanine44 24 1110.9SRY, FSHR, LHCGR
35deoxyribonucleic acid448.9SRY, FSHR, FSHB
36leuprolide acetate448.9LHCGR, GNRH1, PRL, FSHB
37buserelin44 28 1110.9LHCGR, GNRH1, PRL, FSHB
38acth448.9LHCGR, GNRH1, PRL, FSHB
39dihydrotestosterone44 28 24 1111.8GNRH1, POR, PRL, SRY
40adenylate448.7LHCGR, GNRH1, FSHB, FSHR
41leucine448.5LHCGR, FSHR, SRY
42gnrh448.4LHCGR, GNRH1, PRL, FSHB, FSHR
43ribonucleic acid448.4FSHR, FSHB, PRL, GNRH1, LHCGR
44progesterone44 28 61 24 1112.4LHCGR, GNRH1, PRL, FSHB, FSHR
45alanine448.2LHCGR, GNRH1, POR, FSHR, SRY
46cysteine448.0SRY, FSHR, FSHB, POR, LHCGR
47estrogen448.0LHCGR, GNRH1, POR, PRL, FSHB, FSHR
48estradiol44 24 119.6LHCGR, GNRH1, PRL, FSHB, FSHR, SRY
49testosterone44 61 24 1110.2SRY, LHCGR, GNRH1, POR, PRL, FSHB
50steroid447.2LHCGR, GNRH1, POR, PRL, FSHB, FSHR

GO Terms for genes affiliated with Amenorrhea

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Biological processes related to Amenorrhea according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.5LHCGR, FSHR
2Sertoli cell proliferationGO:0600119.5FSHR, FSHB
3male gonad developmentGO:0085849.4FSHR, LHCGR
4regulation of osteoclast differentiationGO:0456709.3FSHB, FSHR
5female gamete generationGO:0072929.2FSHR, FSHB
6phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.1FSHR, LHCGR
7female pregnancyGO:0075659.1FSHB, PRL, GNRH1

Molecular functions related to Amenorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.0FSHB, PRL, GNRH1

Products for genes affiliated with Amenorrhea

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Sources for Amenorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet