MCID: AMN009
MIFTS: 29

Amniotic Band Syndrome

Categories: Rare diseases, Genetic diseases

Aliases & Classifications for Amniotic Band Syndrome

MalaCards integrated aliases for Amniotic Band Syndrome:

Name: Amniotic Band Syndrome 50 69
Constricting Bands, Congenital 69
Congenital Constricting Bands 50
Amniotic Bands Sequence 50
Familial Amniotic Bands 50
Streeter Anomaly 50

Classifications:



Summaries for Amniotic Band Syndrome

NIH Rare Diseases : 50 amniotic band syndrome refers to a condition in which bands develop from the inner lining of the amnion. the amnion is the sac that surrounds the baby in the womb. as the baby develops in the womb, the bands may attach to and affect the development of different areas of the body. this may result in constriction of the affected area or even amputation. the signs and symptoms vary greatly depending on the area(s) of the body involved and may include: shortened or absent digits (fingers and/or toes) or limbs (arms and/or legs), an opening in the abdomen through which various abdominal organs can protrude (abdominal wall defects), protrusion of a portion of the brain and its surrounding membranes through a skull defect (encephalocele), and cleft lip and/or palate. in most instances, the cause of amniotic bands remains unknown. researchers have suggested two main theories to explain the development: the extrinsic theory and the intrinsic theory. the extrinsic theory states that amniotic band syndrome occurs due to factors found outside of the developing baby (externally); the intrinsic theory states that amniotic band syndrome occurs due to factors found within the baby (internally). treatment differs depending on the severity of the condition and the areas of the body affected and may include surgery, physical therapy, and occupational therapy. last updated: 3/21/2017

MalaCards based summary : Amniotic Band Syndrome, also known as constricting bands, congenital, is related to hypoglossia-hypodactylia and anencephaly, and has symptoms including lymphedema, split hand and oligohydramnios. The drugs Ephedrine and Pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and skin.

Related Diseases for Amniotic Band Syndrome

Diseases related to Amniotic Band Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
id Related Disease Score Top Affiliating Genes
1 hypoglossia-hypodactylia 10.9
2 anencephaly 9.9
3 pseudoarthrosis 9.8
4 meningocele 9.8
5 epidermolysis bullosa 9.8
6 cleft lip 9.8
7 prune belly syndrome 9.6
8 twin-to-twin transfusion syndrome 9.6
9 granuloma annulare 9.6
10 lymphedema 9.6
11 orofacial cleft 9.6
12 clubfoot 9.6
13 coloboma 9.6
14 teratoma 9.6
15 strabismus 9.6
16 herpes simplex 9.6
17 chorioretinitis 9.6
18 acalvaria 9.6
19 aplasia cutis congenita 9.6
20 dominant dystrophic epidermolysis bullosa 9.6
21 limb-body wall complex 9.6

Graphical network of the top 20 diseases related to Amniotic Band Syndrome:



Diseases related to Amniotic Band Syndrome

Symptoms & Phenotypes for Amniotic Band Syndrome

Human phenotypes related to Amniotic Band Syndrome:

32 (show all 10)
id Description HPO Frequency HPO Source Accession
1 lymphedema 32 frequent (33%) HP:0001004
2 split hand 32 hallmark (90%) HP:0001171
3 oligohydramnios 32 frequent (33%) HP:0001562
4 talipes 32 hallmark (90%) HP:0001883
5 pulmonary hypoplasia 32 frequent (33%) HP:0002089
6 scoliosis 32 frequent (33%) HP:0002650
7 mitten deformity 32 hallmark (90%) HP:0004057
8 finger syndactyly 32 hallmark (90%) HP:0006101
9 aplasia/hypoplasia of the radius 32 frequent (33%) HP:0006501
10 amniotic constriction ring 32 hallmark (90%) HP:0009775

Drugs & Therapeutics for Amniotic Band Syndrome

Drugs for Amniotic Band Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
2
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
3 Autonomic Agents Phase 1, Phase 2
4 Nasal Decongestants Phase 1, Phase 2
5 Ophthalmic Solutions Phase 1, Phase 2
6 Peripheral Nervous System Agents Phase 1, Phase 2
7 Pharmaceutical Solutions Phase 1, Phase 2
8 Respiratory System Agents Phase 1, Phase 2
9 Tetrahydrozoline Phase 1, Phase 2
10 Vasoconstrictor Agents Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing Completed NCT02746848 Phase 1, Phase 2

Search NIH Clinical Center for Amniotic Band Syndrome

Genetic Tests for Amniotic Band Syndrome

Anatomical Context for Amniotic Band Syndrome

MalaCards organs/tissues related to Amniotic Band Syndrome:

39
Brain, Eye, Skin, Spinal Cord, Cervix

Publications for Amniotic Band Syndrome

Articles related to Amniotic Band Syndrome:

(show top 50) (show all 149)
id Title Authors Year
1
Aplasia cutis congenita and amniotic band syndrome: an uncommon association. ( 28143861 )
2017
2
Management of the Amniotic Band Syndrome with Cleft Palate: Literature Review and Report of a Case. ( 28246561 )
2017
3
Amniotic Band Syndrome With Pseudoarthrosis of Tibia and Fibula: A Case Report. ( 28623060 )
2017
4
Amniotic band syndrome with pseudoarthrosis of tibia and fibula: A case report. ( 28737311 )
2017
5
Uterine contractility as a cause of amniotic band syndrome. ( 27048015 )
2016
6
Two rare cases of simultaneous Tessier number 3 cleft, contralateral cleft lip, and signs of amniotic band syndrome. ( 27052637 )
2016
7
Case of dominant dystrophic epidermolysis bullosa with amniotic band syndrome. ( 27130450 )
2016
8
Amniotic Band Syndrome - A Dreaded Condition. ( 26894130 )
2016
9
Amniotic Band Syndrome, Perinatal Hospice, and Palliative Care versus Active Management. ( 28025631 )
2016
10
Prenatal diagnosis of amniotic band syndrome. ( 27081225 )
2016
11
EP01.10: Amniotic band syndrome mimicking isolated anencephaly. ( 27646670 )
2016
12
Role of Ultrasound in Body Stalk Anomaly and Amniotic Band Syndrome. ( 27699204 )
2016
13
Image Gallery: Amniotic band syndrome. ( 27317293 )
2016
14
The amniotic band syndrome in the rat is associated with the activation of transforming growth factor-I^. ( 26055209 )
2015
15
Oral Rehabilitation for Amniotic Band Syndrome: An Unusual Presentation. ( 26124582 )
2015
16
An unusual craniofacial cleft: amniotic band syndrome as a possible cause. ( 25661732 )
2015
17
Placento-Cranial Adhesions in Amniotic Band Syndrome and the Role of Surgery in Their Management: An Unusual Case Presentation and Systematic Literature Review. ( 26159096 )
2015
18
Amniotic band syndrome: a single-institutional experience. ( 25531236 )
2015
19
Novel techniques for the surgical management of abdominopelvic constriction rings in amniotic band syndrome. ( 25626800 )
2015
20
The Effectiveness of the Ponseti Method for Treating Clubfoot Associated With Amniotic Band Syndrome. ( 25985370 )
2015
21
Human tail: a rare feature of amniotic band syndrome? ( 26287557 )
2015
22
Amniotic band syndrome with sacral agenesis and umbilical cord entrapment: A case report emphasizing the value of evaluation of umbilical cord. ( 25926929 )
2015
23
Dystrophic Epidermolysis Bullosa Associated with Amniotic Band Syndrome. ( 24383893 )
2014
24
Prenatal diagnosis of amniotic band syndrome - risk factors and ultrasonic signs. ( 24735486 )
2014
25
Surgical Treatment of Active Amniotic Band Syndrome (ABS) by Z-plasty and Radical Excision of the Overgrown Tissue: A Report of 2 Cases With Progressive Lymphedema Causing Vascular Insufficiency. ( 25264558 )
2014
26
Circumferential trunk skin defect; a rare presentation of amniotic band syndrome. ( 25223247 )
2014
27
A rare form of congenital amniotic band syndrome: total circular abdominal constriction band. ( 24883282 )
2014
28
Fetoscopic approach to amniotic band syndrome. ( 24528986 )
2014
29
Amniotic band syndrome (ABS): can something be done during pregnancy in African poor countries? Three cases and review of the literature. ( 24779260 )
2014
30
Integration of three-dimensional ultrasonography in the prenatal diagnosis of amniotic band syndrome: A case report. ( 24790518 )
2014
31
The epithelial mesenchymal transition process may contribute to the pathogenesis of amniotic band syndrome. ( 24998668 )
2014
32
Abdominal amniotic band associated with fenestrated syndactyly: a rare amniotic band syndrome presentation. ( 23994229 )
2013
33
Amniotic band syndrome. ( 24426485 )
2013
34
Amniotic band syndrome associated with an atypical iris and optic nerve defect. ( 24054035 )
2013
35
Epidemiology and risk factors of amniotic band syndrome, or ADAM sequence. ( 23272276 )
2012
36
Use of the DCI video laryngoscope system in a pediatric patient with amniotic band syndrome and craniofacial abnormalities affecting the airway. ( 22414710 )
2012
37
Development of a fetal rabbit model to study amniotic band syndrome. ( 22432900 )
2012
38
Ethmocephaly with amniotic band syndrome. ( 23248551 )
2012
39
prenatal diagnosis of amniotic band syndrome in the third trimester of pregnancy using 3D ultrasound. ( 22616039 )
2012
40
Median facial cleft in amniotic band syndrome. ( 21731335 )
2011
41
Amniotic band syndrome with tethering of the spinal cord: a case-based update. ( 21080173 )
2011
42
Laser therapy for twin-to-twin transfusion syndrome causing amniotic band syndrome. ( 21037281 )
2011
43
Amniotic band syndrome: a case report. ( 21837919 )
2011
44
A case of amniotic band syndrome with cleft lip and palate. ( 23204754 )
2011
45
3D/4D sonographic evaluation of amniotic band syndrome in early pregnancy: a supplement to 2D ultrasound. ( 21375678 )
2011
46
Congenital vascular anomalies in amniotic band syndrome of the limbs. ( 21376201 )
2011
47
Amniotic band syndrome associated with sacral meningocele and anal atresia. ( 20723131 )
2010
48
Amniotic band syndrome and/or limb body wall complex: split or lump. ( 23776348 )
2010
49
Thigh-leg skin tube pedicle and amniotic band syndrome. ( 19365743 )
2009
50
Abdominal constriction bands are a rare complication of the amniotic band syndrome. ( 19064344 )
2009

Variations for Amniotic Band Syndrome

Expression for Amniotic Band Syndrome

Search GEO for disease gene expression data for Amniotic Band Syndrome.

Pathways for Amniotic Band Syndrome

GO Terms for Amniotic Band Syndrome

Sources for Amniotic Band Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....