MCID: AMP007
MIFTS: 36

Amphetamine Abuse

Categories: Mental diseases

Aliases & Classifications for Amphetamine Abuse

MalaCards integrated aliases for Amphetamine Abuse:

Name: Amphetamine Abuse 12 51 14

Classifications:



External Ids:

Disease Ontology 12 DOID:670
ICD9CM 34 305.7
UMLS 69 C0154536

Summaries for Amphetamine Abuse

Disease Ontology : 12 A substance abuse that involves the recurring use of amphetamines despite negative consequences.

MalaCards based summary : Amphetamine Abuse is related to atypical depressive disorder and alcohol-induced mental disorder. An important gene associated with Amphetamine Abuse is SLC6A3 (Solute Carrier Family 6 Member 3), and among its related pathways/superpathways are Circadian entrainment and Taste transduction. The drugs Dopamine and Amphetamine have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Amphetamine Abuse

Diseases related to Amphetamine Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 atypical depressive disorder 10.3 HTR7 MAOB
2 alcohol-induced mental disorder 10.3 NPS SLC6A3
3 specific developmental disorder 10.2 HTR7 SLC6A2 SLC6A3
4 personality disorder 10.2 HTR1B MAOB SLC6A3
5 restless legs syndrome 10.1 MAOB NTS SLC6A3
6 mood disorder 10.1 HTR1B MAOB SLC6A2
7 anxiety 10.0 NPS SLC6A2 SLC6A3
8 myocardial infarction 10.0
9 acute myocardial infarction 10.0
10 oculogyric crisis 10.0 KANTR MAOB
11 alcohol dependence 10.0 HTR1B HTR7 MAOB SLC6A3
12 cerebritis 9.9
13 alcoholic psychosis 9.9 NPS SLC6A3
14 nervous system disease 9.9 KANTR MAOB SLC6A3
15 postencephalitic parkinson disease 9.9 KANTR MAOB
16 attention deficit-hyperactivity disorder 9.8 GRM5 HTR1B MAOB SLC6A2 SLC6A3
17 narcolepsy 9.8 MAPK14 NPS SLC6A2 SLC6A3
18 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
19 transsexuality 9.8
20 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.8
21 holoprosencephaly 9.8
22 thrombosis 9.8
23 transsexualism 9.8
24 arteriovenous malformation 9.8
25 superior mesenteric artery syndrome 9.8
26 streptococcal group a invasive disease 9.8
27 aneurysm 9.8
28 major depressive disorder 9.8 GRM2 GRM5 HTR1B SLC6A2 SLC6A3
29 central nervous system disease 9.7 GRM2 GRM5 MAOB SLC6A2 SLC6A3
30 synucleinopathy 9.6 GRM5 MAOB PVALB SLC6A3
31 migraine with or without aura 1 9.4 HTR1B HTR7 KANTR MAOB NPS SLC6A3
32 parkinson disease, late-onset 9.0 GRM5 MAOB MAPK14 NTS PVALB SLC6A3
33 disease of mental health 8.9 GRM2 GRM5 HTR7 NPS PVALB SLC6A2
34 schizophrenia 8.5 GRM2 GRM5 HTR1B HTR7 MAOB NTS

Graphical network of the top 20 diseases related to Amphetamine Abuse:



Diseases related to Amphetamine Abuse

Symptoms & Phenotypes for Amphetamine Abuse

MGI Mouse Phenotypes related to Amphetamine Abuse:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ARC GRM2 GRM5 HTR1B HTR7 MAOB
2 homeostasis/metabolism MP:0005376 9.7 GRM2 HTR7 IVD MAOB MAP3K5 MAPK14
3 nervous system MP:0003631 9.36 ARC GRM2 GRM5 HTR7 MAOB MAPK14

Drugs & Therapeutics for Amphetamine Abuse

Drugs for Amphetamine Abuse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Amphetamine Approved, Illicit, Investigational Phase 4,Phase 2,Phase 1 300-62-9 3007 5826
3
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
4
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
5 Adrenergic Agents Phase 4,Phase 2,Phase 1
6 Central Nervous System Stimulants Phase 4,Phase 2,Phase 1
7 Neurotransmitter Agents Phase 4,Phase 2,Phase 1
8 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Phase 1
9 Dopamine Agents Phase 4,Phase 2,Phase 1
10 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
11 Dopamine Uptake Inhibitors Phase 4,Phase 2,Phase 1
12 Autonomic Agents Phase 4,Phase 2,Phase 1
13 Quetiapine Fumarate Phase 4 111974-72-2
14
Serotonin Phase 4 50-67-9 5202
15 Central Nervous System Depressants Phase 4
16 Serotonin Agents Phase 4
17 Serotonin Antagonists Phase 4
18 Tranquilizing Agents Phase 4
19 Vasoconstrictor Agents Phase 4
20 Anesthetics Phase 4
21 Anesthetics, Local Phase 4
22 Dopamine Antagonists Phase 4
23 Psychotropic Drugs Phase 4
24 Antipsychotic Agents Phase 4
25
Dextroamphetamine Approved, Illicit Phase 2,Phase 1 51-64-9 5826
26
Diethylpropion Approved, Illicit Phase 1, Phase 2 90-84-6, 134-80-5 7029
27 Anti-Obesity Agents Phase 1, Phase 2
28 Lisdexamfetamine Dimesylate Phase 2,Phase 1
29 Appetite Depressants Phase 1, Phase 2
30
Methamphetamine Approved, Illicit 537-46-2 10836
31
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
32
Sage Approved, Nutraceutical
33
Choline Approved, Nutraceutical 62-49-7 305
34 Chlorpheniramine, phenylpropanolamine drug combination
35 N-Methyl-3,4-methylenedioxyamphetamine
36 Cytidine Diphosphate Choline
37 Nootropic Agents
38 Antidepressive Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia Completed NCT00208143 Phase 4 Quetiapine;Risperidone
2 Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories Completed NCT00247572 Phase 2 NRP104
3 Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse Completed NCT00248092 Phase 1, Phase 2 NRP104
4 Combination of Psychosocial Intervention and Slow Prosecutions for the Treatment of Methamphetamine Abuse/Dependence Unknown status NCT01273701
5 A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence Completed NCT00377299 Citicoline;Placebo
6 Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging Completed NCT01296802 dexfenfluramine

Search NIH Clinical Center for Amphetamine Abuse

Genetic Tests for Amphetamine Abuse

Anatomical Context for Amphetamine Abuse

Publications for Amphetamine Abuse

Articles related to Amphetamine Abuse:

(show top 50) (show all 80)
# Title Authors Year
1
Cardiovascular Complications of Acute Amphetamine Abuse: Cross-sectional study. ( 28417026 )
2017
2
Tamoxifen and amphetamine abuse: Are there therapeutic possibilities? ( 27585851 )
2016
3
Facial movement disorder and dopamine imaging in a patient with amphetamine abuse. ( 27502592 )
2016
4
Amphetamine Abuse Related Acute Myocardial Infarction. ( 26998366 )
2016
5
Superior Mesenteric Artery Syndrome Associated with Rapid Weight Loss Attributed to Amphetamine Abuse. ( 26351593 )
2015
6
Methamphetamine/amphetamine abuse and risk of Parkinson's disease in Utah: a population-based assessment. ( 25479916 )
2015
7
Amphetamine abuse as a rare cause of recurrent LVAD pump thrombosis. ( 25545600 )
2015
8
Extreme Procalcitonin Elevation without Proven Bacterial Infection Related to Amphetamine Abuse. ( 24826347 )
2014
9
Factors associated with buprenorphine compared to amphetamine abuse among clients seeking treatment in Finland. ( 24560129 )
2014
10
Efficacy of psychostimulant drugs for amphetamine abuse or dependence. ( 23996457 )
2013
11
Amphetamine abuse in Sweden: subject demographics, changes in blood concentrations over time, and the types of coingested substances. ( 23422398 )
2013
12
Androgenic anabolic steroid, cocaine and amphetamine abuse and adverse cardiovascular effects. ( 24719633 )
2013
13
Amphetamine abuse in emergency department patients undergoing psychiatric evaluation. ( 22538120 )
2012
14
Acute demyelination in a person with amphetamine abuse. ( 22937385 )
2011
15
Rhabdomyolysis accompanied by spontaneous spinal subdural and subarachnoid hematoma related to amphetamine abuse. ( 20081506 )
2010
16
Modafinil treatment of amphetamine abuse in adult ADHD. ( 18562425 )
2009
17
The prevalence of methamphetamine and amphetamine abuse in North America: a review of the indicators, 1992-2007. ( 18368603 )
2008
18
Hospitalizations with amphetamine abuse among pregnant women. ( 18238971 )
2008
19
Amphetamine abuse in pregnancy: the impact on obstetric outcome. ( 17285340 )
2007
20
Contrast enhanced computer tomography of two cases of bilateral acute cortical necrosis, one of which related to amphetamine abuse. ( 16133628 )
2005
21
Coronary artery rupture associated with amphetamine abuse. ( 15316310 )
2004
22
Asia grapples with spreading amphetamine abuse. ( 12788585 )
2003
23
Amphetamine abuse in pregnancy: anesthetic implications. ( 12872434 )
2003
24
Rapidly growing internal carotid artery aneurysm after amphetamine abuse: case report. ( 12604995 )
2003
25
Altered response to intravenous thiopental and succinylcholine in acute amphetamine abuse. ( 12027859 )
2002
26
Massive intracerebral hematoma and extradural hematoma in amphetamine abuse. ( 11781916 )
2002
27
Vertebral artery dissection with amphetamine abuse. ( 17903796 )
2001
28
Differentiation of clobenzorex use from amphetamine abuse using the metabolite 4-hydroxyclobenzorex. ( 11043667 )
2000
29
Amphetamine abuse during pregnancy: environmental factors and outcome after 14-15 years. ( 10954143 )
2000
30
Dexamphetamine substitution in the treatment of amphetamine abuse: an initial investigation. ( 10723851 )
2000
31
Amphetamine abuse and intracranial haemorrhage. ( 11089483 )
2000
32
Intracerebral haemorrhage in a young adult: consider amphetamine abuse. ( 8731653 )
1996
33
Intracerebral haemorrhage due to amphetamine abuse: report of two cases with underlying arteriovenous malformations. ( 7786436 )
1995
34
Consumption coagulopathy after amphetamine abuse in pregnancy. ( 7660777 )
1995
35
Acute myocardial infarction resulting from amphetamine abuse: a spasm-thrombus interplay? ( 7985607 )
1994
36
Holoprosencephaly and trisomy 13 in a fetus with maternal early gestational amphetamine abuse--a case report. ( 8207770 )
1993
37
Intraventricular hemorrhage following amphetamine abuse. ( 2381547 )
1990
38
Acute myocardial infarction caused by intravenous amphetamine abuse. ( 2390398 )
1990
39
Bladder outflow obstruction secondary to intravenous amphetamine abuse. ( 2804574 )
1989
40
Update on amphetamine abuse. ( 18750614 )
1989
41
Intracranial haemorrhage caused by amphetamine abuse. ( 2614776 )
1989
42
Intracerebral hemorrhage and angiographic beading following amphetamine abuse. ( 3356528 )
1988
43
Psychotic manifestations in amphetamine abuse--experimental study on the mechanism of psychotic recurrence. ( 3797582 )
1986
44
Intravenous amphetamine abuse, primary cerebral mucormycosis, and acquired immunodeficiency. ( 3998699 )
1985
45
Nails as useful materials for detection of methamphetamine or amphetamine abuse. ( 6698458 )
1984
46
Acute cardiomyopathy secondary to intravenous amphetamine abuse. ( 7125413 )
1982
47
Amphetamine abuse and transsexualism. ( 7108506 )
1982
48
Intracranial hemorrhage with amphetamine abuse. ( 7196521 )
1981
49
Violence: the ugly face of amphetamine abuse. ( 6114085 )
1981
50
Intracranial hemorrhage with amphetamine abuse. ( 7191505 )
1980

Variations for Amphetamine Abuse

Expression for Amphetamine Abuse

Search GEO for disease gene expression data for Amphetamine Abuse.

Pathways for Amphetamine Abuse

GO Terms for Amphetamine Abuse

Cellular components related to Amphetamine Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.92 GRM2 GRM5 SLC6A2 SLC6A3

Biological processes related to Amphetamine Abuse according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.91 GRM2 GRM5 HTR1B HTR7 ITK MAPK14
2 response to drug GO:0042493 9.8 HTR1B MAOB SLC6A2 SLC6A3
3 response to ethanol GO:0045471 9.7 HTR1B MAOB SLC6A3
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.55 HTR1B MAP3K5
5 positive regulation of myoblast differentiation GO:0045663 9.54 MAP3K5 MAPK14
6 vasoconstriction GO:0042310 9.51 HTR1B HTR7
7 G-protein coupled glutamate receptor signaling pathway GO:0007216 9.48 GRM2 GRM5
8 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007196 9.46 GRM2 GRM5
9 monoamine transport GO:0015844 9.43 SLC6A2 SLC6A3
10 dopamine catabolic process GO:0042420 9.4 MAOB SLC6A3
11 dopamine uptake involved in synaptic transmission GO:0051583 9.37 SLC6A2 SLC6A3
12 p38MAPK cascade GO:0038066 9.32 MAP3K5 MAPK14
13 negative regulation of serotonin secretion GO:0014063 9.16 HTR1B MAOB
14 chemical synaptic transmission GO:0007268 9.02 GRM2 GRM5 HTR1B HTR7 SLC6A2
15 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 8.96 HTR1B HTR7

Molecular functions related to Amphetamine Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamate receptor activity GO:0008066 9.26 GRM2 GRM5
2 serotonin binding GO:0051378 9.16 HTR1B HTR7
3 monoamine transmembrane transporter activity GO:0008504 8.96 SLC6A2 SLC6A3
4 dopamine:sodium symporter activity GO:0005330 8.62 SLC6A2 SLC6A3

Sources for Amphetamine Abuse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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