Ampulla of Vater Carcinoma disease: drugs, articles, genes, clinical trials

Summaries for Ampulla of Vater Carcinoma

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MalaCards: Ampulla of Vater Carcinoma, also known as carcinoma of ampulla of vater (disorder), is related to thyroid carcinoma and squamous cell carcinoma. An important gene associated with Ampulla of Vater Carcinoma is MCRS1 (microspherule protein 1), and among its related pathways are Sorafenib Pharmacodynamics and Development_EGFR signaling via small GTPases. The drugs carmustine and diethylstilbestrol diphosphate and the compounds sialic acid and polysaccharide have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Aliases & Descriptions for Ampulla of Vater Carcinoma

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Sources:
⁶Disease Ontology, ⁸DISEASES, ⁴³UMLS, ⁴⁰SNOMED-CT, ²⁷NCIt
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Aliases & Descriptions:

ampulla of vater carcinoma ⁶ ⁸

carcinoma of ampulla of vater (disorder) ⁶

carcinoma of ampulla of vater ⁴³

ampulla of vater cancer ⁶

ampullary carcinoma ⁶

carcinoma ⁴³

External Ids:

NCIt²⁷ C3908

SNOMED-CT⁴⁰ 254609000

UMLS⁴³ C0262401

Related Diseases for Ampulla of Vater Carcinoma

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¹³GeneCards, ¹⁴GeneDecks
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Diseases related to ampulla of vater carcinoma by text searches and GeneDecks gene sharing:

(show top 50) (show all 1297)

id	Related Disease	Score	Top Affiliating Genes
1	thyroid carcinoma	36.7	PIK3CA, BRAF, MCRS1, ERBB2, EGFR, PSG2
2	squamous cell carcinoma	35.9	PIK3CA, MUC1, MUC2, MUC5AC, MUC6, FGFR2
3	renal cell carcinoma	35.8	PIK3CA, KIT, BRAF, MUC1, FGFR2, KRT7
4	hepatocellular carcinoma	34.8	PIK3CA, KIT, BRAF, MUC1, MUC2, MUC5AC
5	oral squamous cell carcinoma	34.7	PIK3CA, BRAF, MUC1, ERBB2, EGFR, PSG2
6	prostate carcinoma	34.0	BRAF, MUC1, ATM, FGFR2, ERBB2, KRT7
7	squamous cell carcinoma of the head and neck	34.0	PIK3CA, BRAF, ERBB2, EGFR, PSG2
8	esophageal squamous cell carcinoma	33.7	PIK3CA, KIT, MUC1, ERBB2, KRT7, EGFR
9	nasopharyngitis	33.6	PIK3CA, KIT, BRAF, MUC5AC, MUC5B, ATM
10	neuroendocrine carcinoma	33.6	KIT, MUC1, KRT7
11	esophageal carcinoma	33.5	KIT, FGFR2, ERBB2, EGFR, PSG2
12	cervical carcinoma	33.4	PIK3CA, KIT, ATM, ERBB2, KRT7, EGFR
13	adenoid cystic carcinoma	33.2	KIT, MUC1, ERBB2, KRT7
14	thyroiditis	33.2	PIK3CA, KIT, BRAF, MUC1, MUC5AC, ATM
15	merkel cell carcinoma	33.1	KIT, MUC1, KRT7
16	non-small cell lung carcinoma	33.0	KIT, BRAF, MUC1, ERBB2, KRT7, EGFR
17	breast carcinoma	33.0	PIK3CA, KIT, BRAF, MUC1, MUC2, MUC5AC
18	papillary thyroid carcinoma	33.0	PIK3CA, BRAF, MUC1, ATM, ERBB2, KRT7
19	basal cell carcinoma	32.9	BRAF, MUC1, MCRS1, ERBB2, KRT7, EGFR
20	ovarian carcinoma	32.7	PIK3CA, KIT, BRAF, MUC1, MUC2, MUC5AC
21	clear cell renal cell carcinoma	32.7	KIT, MUC1, KRT7, EGFR
22	small cell carcinoma	32.4	KIT, MUC1, ERBB2, KRT7, EGFR, EPHB2
23	laryngitis	32.4	PIK3CA, MUC1, MUC2, MUC5AC, MUC5B, MUC6
24	esophagitis	32.2	PIK3CA, KIT, BRAF, MUC1, MUC2, MUC5AC
25	breast cancer	32.2	PIK3CA, ERBB2, EGFR, EPHA3
26	endometrial carcinoma	32.0	PIK3CA, KIT, BRAF, MUC1, MUC2, MUC5AC
27	mucoepidermoid carcinoma	31.7	MUC1, MUC2, MUC5AC, MUC6, EGFR, PSG2
28	bladder carcinoma	31.6	PIK3CA, BRAF, MUC1, MUC2, FGFR2, ERBB2
29	ductal carcinoma in situ	31.6	PIK3CA, KIT, MUC1, FGFR2, ERBB2, EGFR
30	papillary renal cell carcinoma	31.5	KIT, MUC1, KRT7, PSG2
31	colorectal adenoma and carcinoma	31.5	MUC1, MUC2, ERBB2
32	lung carcinoma	31.4	PIK3CA, KIT, BRAF, MUC1, MUC2, MUC5AC
33	pancreatic ductal carcinoma	31.3	MUC2, MUC5AC, MUC6, KRT7
34	gallbladder carcinoma	31.2	PIK3CA, MUC1, MUC2, ERBB2, EGFR, PSG2
35	hypoxia	31.0	PIK3CA, KIT, BRAF, MUC1, ATM, MCRS1
36	large cell carcinoma	30.9	ERBB2, KRT7, EGFR
37	adenoiditis	30.9	PIK3CA, KIT, MUC1, MUC5AC, ERBB2, KRT7
38	hepatitis c	30.8	PIK3CA, BRAF, MUC1, ATM, MCRS1, KRT7
39	anaplastic carcinoma	30.7	BRAF, MUC1, KRT7
40	prostatitis	30.7	PIK3CA, KIT, BRAF, MUC1, MUC2, MUC5AC
41	cervicitis	30.7	PIK3CA, KIT, BRAF, MUC1, MUC2, MUC5AC
42	adenosquamous carcinoma	30.6	KIT, MUC1, KRT7, EGFR
43	hepatitis	30.6	PIK3CA, KIT, BRAF, MUC1, MUC6, ATM
44	chromophobe renal cell carcinoma	30.4	KIT, MUC1, KRT7, EGFR
45	bile duct carcinoma	30.3	KIT, MUC1, MUC2, MUC6, ERBB2
46	thymic carcinoma	30.2	KIT, MUC1, KRT7, EGFR
47	lymphoepithelioma-like carcinoma	30.1	MUC1, EGFR
48	renal oncocytoma	29.9	KIT, MUC1, KRT7, PSG2
49	thyroid medullary carcinoma	29.8	MUC2, ERBB2, KRT7, PSG2
50	peritonitis	29.8	KIT, MUC1, MUC2, MUC5AC, FGFR2, ERBB2

Graphical network of the top 20 diseases related to ampulla of vater carcinoma:

Graphical network of diseases related to ampulla of vater carcinoma

Clinical Features for Ampulla of Vater Carcinoma

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Drugs & Therapeutics for Ampulla of Vater Carcinoma

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⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

Search CenterWatch for ampulla of vater carcinoma

Drug clinical trials:

Search ClinicalTrials for ampulla of vater carcinoma

Search NIH Clinical Center for ampulla of vater carcinoma

Search CenterWatch for ampulla of vater carcinoma

Inferred drug relations via UMLS/NDF-RT:

⁴³ ²⁸ carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

Genetic Tests for Ampulla of Vater Carcinoma

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Anatomical Context for Ampulla of Vater Carcinoma

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Phenotypes for genes affiliated with Ampulla of Vater Carcinoma

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²⁵MGI
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MGI Mouse Phenotypes related to ampulla of vater carcinoma:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.2	FGFR2
2	liver/biliary system phenotype	MP:0005370	9.6	KIT, EGFR
3	craniofacial phenotype	MP:0005382	9.4	EPHB2, FGFR2, KIT
4	no phenotypic analysis	MP:0003012	8.8	MUC1, ATM, EGFR
5	vision/eye phenotype	MP:0005391	7.4	EPHB2, EGFR, FGFR2, MUC1, BRAF, KIT
6	embryogenesis phenotype	MP:0005380	7.3	EGFR, ERBB2, FGFR2, ATM, BRAF, KIT
7	cardiovascular system phenotype	MP:0005385	7.1	EPHA3, EGFR, ERBB2, FGFR2, MUC2, BRAF
8	reproductive system phenotype	MP:0005389	6.8	EPHB2, EGFR, ERBB2, FGFR2, ATM, MUC1
9	digestive/alimentary phenotype	MP:0005381	6.6	EPHB2, EGFR, ERBB2, FGFR2, MUC5AC, MUC2
10	cellular phenotype	MP:0005384	6.5	EPHB2, EGFR, ERBB2, FGFR2, ATM, MUC2
11	tumorigenesis	MP:0002006	6.5	PIK3CA, EGFR, ERBB2, FGFR2, ATM, MUC2

Publications for genes affiliated with Ampulla of Vater Carcinoma

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³⁵PubMed
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Articles related to ampulla of vater carcinoma:

id	Title	Authors	Year	Affiliating Genes
1	Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (20838624)	Corbo V.... Scarpa A.	2010	FGFR2, ERBB2, EGFR
2	Determinants of long-term survival after pancreatico duodenectomy for ampulla of Vater carcinoma (20223115)	Chen J.Y.... Dong J.H.	2009	PSG2
3	The clinicopathologic and immunohistochemical charact eristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis. (18019683)	Roh Y.H.... Jung G.J.	2007	MUC5AC
4	Prognostic value of MIB-1 index and DNA ploidy in res ectable ampulla of Vater carcinoma. (10203085)	Shyr Y.M.... Lui W.Y.	1999	MCRS1

Genes related to Ampulla of Vater Carcinoma

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¹³GeneCards
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Genes related to ampulla of vater carcinoma according to GeneCards:

(show all 17)

id	Symbol	Description	Score	GeneCards Section Context
1	MCRS1	microspherule protein 1	11.0	Publications
2	MUC6	mucin 6, oligomeric mucus/gel-forming	11.0
3	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.0
4	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
5	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0
6	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
7	EPHB2	EPH receptor B2	11.0	Publications
8	KRT7	keratin 7	11.0
9	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0	Publications
10	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
11	ATM	ataxia telangiectasia mutated	11.0	Publications
12	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
13	EPHA3	EPH receptor A3	11.0	Publications
14	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
15	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications
16	MUC1	mucin 1, cell surface associated	11.0
17	EGFR	epidermal growth factor receptor	11.0	Publications

Expression for genes affiliated with Ampulla of Vater Carcinoma

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Ampulla of Vater Carcinoma

Pathways for genes affiliated with Ampulla of Vater Carcinoma

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Sources:
³⁴PharmGKB, ⁴¹Thomson Reuters, ³⁶QIAGEN, ¹⁰EMD Millipore, ³⁸Reactome, ²⁰KEGG, ³Cell Signaling Technology
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Pathways related to ampulla of vater carcinoma according to GeneDecks:

(show top 50) (show all 69)

id	Pathway	Score	Top Affiliating Genes
1	Sorafenib Pharmacodynamics³⁴	10.0	BRAF, PIK3CA
2	Development_EGFR signaling via small GTPases⁴¹	10.0	ERBB2
3	Mucin expression in CF via TLRs, EGFR signaling pathways⁴¹	9.6	MUC2, MUC5AC, MUC5B, EGFR
4	JNK Pathway³⁶	9.5	EPHA3, FGFR2, KIT
5	G-protein signaling_K-RAS regulation pathway⁴¹	9.5	PIK3CA, BRAF, EGFR
6	G-protein signaling K-RAS regulation pathway¹⁰	9.4	PIK3CA, BRAF, EGFR
7	Development ERBB-family signaling¹⁰	9.3	ERBB2, EGFR
8	Pathway_PA165980050³⁴	9.3	BRAF, FGFR2, EGFR
9	Development_EGFR signaling via PIP3⁴¹	9.2	EGFR, ERBB2, PIK3CA
10	Development EGFR signaling via PIP3¹⁰	9.2	EGFR, ERBB2, PIK3CA
11	Molecular Mechanisms of Cancer³⁶	9.2	ATM, FGFR2, EGFR, EPHB2
12	Termination of O-glycan biosynthesis³⁸	9.1	MUC6, MUC5B, MUC5AC, MUC2, MUC1
13	Development EGFR signaling via small GTPases¹⁰	9.1	EGFR, ERBB2, PIK3CA
14	14-3-3 Induced Intracellular Signaling³⁶	9.0	EPHB2, EPHA3, ERBB2, FGFR2
15	Activation of cAMP-Dependent PKA³⁶	9.0	EPHB2, EPHA3, ERBB2, FGFR2
16	Endometrial cancer²⁰	9.0	EGFR, ERBB2, BRAF, PIK3CA
17	Non-small cell lung cancer²⁰	9.0	EGFR, ERBB2, BRAF, PIK3CA
18	Bladder cancer²⁰	8.9	BRAF, ERBB2, EGFR
19	ErbB signaling pathway²⁰	8.9	EGFR, ERBB2, BRAF, PIK3CA
20	Alzheimers Disease Pathway³⁶	8.9	EGFR, ERBB2, FGFR2
21	Pathways in cancer²⁰	8.9	PIK3CA, FGFR2, ERBB2, EGFR
22	Tyrosine Kinases / Adaptors³	8.7	EGFR, ERBB2, FGFR2, KIT
23	p53 Mediated Apoptosis³⁶	8.6	EGFR, FGFR2, ATM, KIT
24	Rho Family GTPases³⁶	8.5	EPHB2, EPHA3, ERBB2, FGFR2, KIT
25	Prostate cancer²⁰	8.5	EGFR, ERBB2, FGFR2, BRAF, PIK3CA
26	EGF Pathway³⁶	8.4	EGFR, ERBB2, MUC1, BRAF
27	Telomerase Components in Cell Signaling³⁶	8.4	KIT, ATM, FGFR2, EGFR
28	Actin Nucleation and Branching³⁶	8.2	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
29	Actin Nucleation by ARP-WASP Complex³⁶	8.2	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
30	CDC42 Pathway³⁶	8.2	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
31	Paxillin Interactions³⁶	8.1	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
32	eNOS Signaling³⁶	8.1	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
33	NFAT in Immune Response³⁶	8.1	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
34	GSK3 Signaling³⁶	8.1	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
35	JAK-STAT Pathway³⁶	8.1	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
36	Intracellular Calcium Signaling³⁶	8.1	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
37	p38 Signaling³⁶	8.0	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
38	Akt Signaling³⁶	8.0	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, KIT
39	P2Y Receptor Signaling³⁶	7.8	KIT, BRAF, FGFR2, ERBB2, EGFR, EPHA3
40	Nanog in Mammalian ESC Pluripotency³⁶	7.8	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
41	Endothelin-1 Signaling Pathway³⁶	7.8	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
42	Ras Pathway³⁶	7.8	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
43	Pancreatic Adenocarcinoma³⁶	7.8	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
44	Estrogen Pathway³⁶	7.8	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
45	GPCR Pathway³⁶	7.7	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
46	Breast Cancer Regulation by Stathmin1³⁶	7.7	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
47	Activation of PKA through GPCR³⁶	7.7	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
48	MAPK Signaling³⁶	7.7	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
49	ERK Signaling³⁶	7.7	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, BRAF
50	ILK Signaling³⁶	7.3	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, MUC1

Compounds for genes affiliated with Ampulla of Vater Carcinoma

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Sources:
³²Novoseek , ⁹DrugBank, ³⁴PharmGKB, ⁴²Tocris Bioscience, ¹⁸HMDB
See all sources

Compounds related to ampulla of vater carcinoma according to GeneDecks:

(show top 50) (show all 89)

id	Compound	Score	Top Affiliating Genes
1	sialic acid³²	10.0	PSG2, MUC5AC, MUC2
2	polysaccharide³²	9.9	FGFR2
3	threonine³²	9.8	MUC2, MUC5AC, FGFR2
4	everolimus³² ⁹ ⁹	11.5	PIK3CA, KIT, EGFR
5	capecitabine³² ³⁴ ⁹ ⁹	12.2	KIT, ERBB2, EGFR
6	rapamycin³² ⁴²	10.2	EPHA3, EGFR, BRAF, KIT
7	b 723³²	9.1	MUC1, KRT7, PSG2
8	geldanamycin³² ⁹ ⁹	11.1	EGFR, ERBB2, BRAF
9	glycogen³² ¹⁸	10.1	EPHA3, PSG2, KRT7, KIT, PIK3CA
10	crcs³²	9.0	MUC2, MUC1, BRAF, PIK3CA
11	17-(allylamino)-17-demethoxygeldanamycin³²	9.0	KIT, BRAF, ERBB2, EPHA3
12	erlotinib³² ³⁴ ⁹ ⁹	12.0	EGFR, ERBB2, KIT, PIK3CA
13	sunitinib³² ⁹ ⁹	11.0	EGFR, ERBB2, KIT
14	5-methylthioadenosine³²	9.0	FGFR2, ERBB2, EGFR
15	ag 1478³²	8.9	EGFR, ERBB2, MUC5AC, PIK3CA
16	irinotecan³² ³⁴ ⁹ ⁹	11.8	EGFR, ERBB2, BRAF, KIT
17	retinoic acid³² ⁴² ¹⁸	10.7	EPHB2, KRT7, FGFR2, BRAF, KIT, PIK3CA
18	hematoxylin³²	8.7	PSG2, KRT7, MUC5AC, MUC2, MUC1, KIT
19	sb 203580³² ⁴²	9.6	EPHB2, EPHA3, EGFR, MUC5AC, MUC2, BRAF
20	glucose³²	8.6	EPHA3, PSG2, KRT7, FGFR2, BRAF, KIT
21	gefitinib³² ³⁴ ⁹ ⁹	11.6	EPHA3, EGFR, ERBB2, KIT, PIK3CA
22	p002³²	8.6	KIT, BRAF, ERBB2, PSG2
23	formaldehyde³² ¹⁸	9.4	PSG2, KRT7, ERBB2, MUC1, KIT
24	ly294002³²	8.3	EGFR, ERBB2, ATM, MUC2, BRAF, PIK3CA
25	methotrexate³² ³⁴ ⁴² ⁹ ⁹	12.2	KRT7, ERBB2, MUC5AC, MUC2, MUC1, KIT
26	phosphotyrosine³²	8.2	EGFR, ERBB2, FGFR2, MUC5AC, KIT, PIK3CA
27	n acetylcysteine³²	8.2	EGFR, ERBB2, FGFR2, ATM, MUC5AC
28	imatinib³² ³⁴ ⁹ ⁹	11.2	EPHA3, EGFR, ERBB2, BRAF, KIT, PIK3CA
29	phosphoinositide³²	8.2	EPHB2, EPHA3, EGFR, ATM, BRAF, KIT
30	paclitaxel³² ³⁴ ⁹ ⁹	11.1	EGFR, ERBB2, FGFR2, BRAF, KIT, PIK3CA
31	doxorubicin³² ³⁴ ⁹ ⁹	10.9	PSG2, EGFR, ERBB2, FGFR2, ATM, KIT
32	estrogen³²	7.9	MUC2, MUC5AC, MUC6, FGFR2, MCRS1, ERBB2
33	trastuzumab³² ³⁴ ⁹ ⁹	10.8	EGFR, ERBB2, FGFR2, MUC1, KIT, PIK3CA
34	agar³²	7.6	EGFR, ERBB2, FGFR2, MUC1, BRAF, PIK3CA
35	tamoxifen³² ³⁴ ⁹ ⁹	10.5	EPHA3, EGFR, ERBB2, FGFR2, MUC1, PIK3CA
36	pd 98,059³²	7.5	EPHB2, EPHA3, EGFR, FGFR2, MUC5AC, MUC2
37	nitric oxide³² ⁹ ¹⁸ ⁹	10.5	EPHA3, PSG2, FGFR2, ATM, MUC5AC, MUC1
38	cisplatin³² ³⁴ ⁹ ⁹	10.3	EGFR, ERBB2, FGFR2, ATM, MUC1, BRAF
39	lipid³²	7.1	EPHA3, PSG2, KRT7, FGFR2, ATM, MUC1
40	adp³² ¹⁸	8.0	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, ATM
41	Adenosine triphosphate⁹ ¹⁸ ⁹	9.0	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, ATM
42	5fluorouracil³²	6.8	PIK3CA, KIT, MUC1, MUC2, MUC5AC, MUC6
43	phosphatidylinositol³²	6.8	ERBB2, EGFR, EPHA3, EPHB2, FGFR2, ATM
44	testosterone³² ⁹ ¹⁸ ⁹	9.7	EPHA3, EGFR, KRT7, ERBB2, FGFR2, MUC5AC
45	calcium³² ⁹ ¹⁸ ⁹	9.7	EPHB2, EPHA3, MCRS1, FGFR2, MUC6, MUC5AC
46	vegf³²	6.3	EPHA3, PSG2, EGFR, KRT7, ERBB2, FGFR2
47	progesterone³² ⁴² ⁹ ¹⁸ ⁹	10.3	EGFR, KRT7, ERBB2, FGFR2, MUC6, MUC5AC
48	paraffin³²	6.0	KRT7, EGFR, PSG2, ERBB2, FGFR2, ATM
49	serine³²	5.7	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, ATM
50	tyrosine³²	5.7	ERBB2, KRT7, EGFR, EPHA3, EPHB2, FGFR2

GO Terms for genes affiliated with Ampulla of Vater Carcinoma

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Sources:
¹²Gene Ontology
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Cellular components related to ampulla of vater carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:005796	8.7	MUC1, MUC2, MUC5AC, MUC5B, MUC6

Biological processes related to ampulla of vater carcinoma according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of ERK1 and ERK2 cascade	GO:070372	9.3	FGFR2, ERBB2
2	peptidyl-tyrosine phosphorylation	GO:018108	9.2	EPHB2, FGFR2, KIT
3	signal transduction by phosphorylation	GO:023014	9.2	KIT, ERBB2
4	positive regulation of epithelial cell proliferation	GO:050679	8.9	EGFR, ERBB2, FGFR2
5	O-glycan processing	GO:016266	8.9	MUC1, MUC2, MUC5AC, MUC5B, MUC6
6	post-translational protein modification	GO:043687	8.8	MUC1, MUC2, MUC5AC, MUC5B, MUC6
7	cellular protein metabolic process	GO:044267	8.7	MUC1, MUC2, MUC5AC, MUC5B, MUC6
8	protein autophosphorylation	GO:046777	8.2	EGFR, ERBB2, FGFR2, ATM, KIT

Molecular functions related to ampulla of vater carcinoma according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	1-phosphatidylinositol-3-kinase activity	GO:016303	9.8	PIK3CA, ATM
2	extracellular matrix structural constituent	GO:005201	9.5	MUC5AC, MUC5B, MUC6
3	epidermal growth factor-activated receptor activity	GO:005006	9.2	ERBB2, EGFR
4	receptor signaling protein tyrosine kinase activity	GO:004716	9.1	EGFR, ERBB2, KIT
5	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.0	EGFR, ERBB2, KIT
6	protein tyrosine kinase activity	GO:004713	8.4	KIT, FGFR2, ERBB2, EGFR, EPHB2
7	ATP binding	GO:005524	6.7	EPHB2, EPHA3, EGFR, ERBB2, FGFR2, ATM
8	protein binding	GO:005515	5.2	MCRS1, ERBB2, KRT7, EGFR, EPHA3, FGFR2

Sources for Ampulla of Vater Carcinoma

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¹BioGPS

²CDC

³Cell Signaling Technology

⁴CenterWatch

⁵ClinicalTrials

⁶Disease Ontology

⁷diseasecard

⁸DISEASES

⁹DrugBank

¹⁰EMD Millipore

¹¹FMA

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MCID: AMP010	Ampulla of Vater Carcinoma malady MalaCards information score (MIFTS): 53.5
4 drugs, 17 genes, 1300 related diseases, 11 phenotypes, 4 articles, clinical trials.

Ampulla of Vater Carcinoma malady

Summaries for Ampulla of Vater Carcinoma

Aliases & Descriptions for Ampulla of Vater Carcinoma

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Related Diseases for Ampulla of Vater Carcinoma

Diseases related to ampulla of vater carcinoma by text searches and GeneDecks gene sharing:

Graphical network of the top 20 diseases related to ampulla of vater carcinoma:

Clinical Features for Ampulla of Vater Carcinoma

Drugs & Therapeutics for Ampulla of Vater Carcinoma

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Anatomical Context for Ampulla of Vater Carcinoma

Phenotypes for genes affiliated with Ampulla of Vater Carcinoma

MGI Mouse Phenotypes related to ampulla of vater carcinoma:

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Expression for genes affiliated with Ampulla of Vater Carcinoma

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Compounds for genes affiliated with Ampulla of Vater Carcinoma

Compounds related to ampulla of vater carcinoma according to GeneDecks:

GO Terms for genes affiliated with Ampulla of Vater Carcinoma

Cellular components related to ampulla of vater carcinoma according to GeneDecks:

Biological processes related to ampulla of vater carcinoma according to GeneDecks:

Molecular functions related to ampulla of vater carcinoma according to GeneDecks:

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