MCID: AMP010
MIFTS: 39

Ampulla of Vater Carcinoma malady

Cancer diseases, Liver diseases, Rare diseases categories
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Summaries for Ampulla of Vater Carcinoma

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Disease Ontology:8 An ampulla of vater cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

MalaCards based summary: Ampulla of Vater Carcinoma, also known as carcinoma of ampulla of vater, is related to adenosquamous carcinoma and cholangiocarcinoma. An important gene associated with Ampulla of Vater Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are NOD-like Receptor Signaling Pathways and O-linked glycosylation of mucins. The compounds cesium chloride and carbohydrates have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node.

Aliases & Classifications for Ampulla of Vater Carcinoma

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Ampulla of Vater Carcinoma, Aliases & Descriptions:

Name: Ampulla of Vater Carcinoma 8 10
Carcinoma of Ampulla of Vater 8 62
Tumor of the Ampulla of Vater 8 62
Ampullary Carcinoma 8 48
Carcinoma of the Ampulla of Vater 48
 
Neoplasm of Ampulla of Vater 62
Ampulla of Vater Neoplasm 8
Ampulla of Vater Cancer 8
Ampulloma 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
ampullary carcinoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


External Ids:

Disease Ontology8 DOID:4932, DOID:10022
NCIt39 C3908, C4443
ICD10 via Orphanet26 C24.1
UMLS via Orphanet63 C0262401
ICD1025 C24.1

Related Diseases for Ampulla of Vater Carcinoma

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Diseases related to Ampulla of Vater Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1adenosquamous carcinoma30.6MUC5AC, MUC2
2cholangiocarcinoma30.3MUC2, MUC5AC, PSG2
3adenocarcinoma30.2PSG2, MUC2, MUC5AC
4gallbladder cancer30.2MUC2, MUC5AC
5adenoma30.2MUC2, MUC5AC, PSG2
6bladder carcinoma30.1PSG2, MUC2
7neuroendocrine carcinoma10.8
8large cell neuroendocrine carcinoma10.6
9gastrointestinal stromal tumor10.6
10biliary papillomatosis10.4MUC2
11small cell neuroendocrine carcinoma10.4
12acinar cell carcinoma10.4
13desmoid tumor10.4
14fibromatosis10.4
15aneurysmal bone cysts10.4
16acalculous cholecystitis10.4
17duodenal ulcer10.4
18obstructive jaundice10.4
19inflammatory myofibroblastic tumor10.4
20cholecystitis10.4
21neuroendocrine tumor10.4
22aneurysm10.4
23ampulla of vater adenosquamous carcinoma10.3
24ampulla of vater squamous cell carcinoma10.3
25ampulla of vater adenocarcinoma10.3
26pancreatitis10.3
27duodenitis10.2
28annular pancreas10.2
29microinvasive gastric cancer10.2PSG2, MUC2
30laryngeal benign neoplasm10.2PSG2, MUC2
31gastric cancer10.1
32situs inversus10.1
33intrahepatic cholangiocarcinoma10.1
34spondyloarthropathy10.1
35endotheliitis10.1
36pseudomyxoma peritonei10.1MUC5AC, MUC2
37papilloma10.1MUC5AC, MUC2
38pancreatic ductal carcinoma10.1MUC5AC, MUC2
39cystadenocarcinoma10.1MUC2, MUC5AC
40bronchiolo-alveolar adenocarcinoma10.1MUC2, MUC5AC
41tubular adenocarcinoma10.1MUC5AC, MUC2
42respiratory failure10.0MUC2, MUC5AC
43factor vii deficiency10.0MUC5AC, PSG2
44barrett's esophagus10.0MUC5AC, MUC2
45pancreatic cancer10.0MUC2, MUC5AC
46familial adenomatous polyposis10.0MUC5AC, MUC2
47chronic obstructive pulmonary disease10.0MUC5AC, MUC2
48colon adenocarcinoma9.9MUC5AC, MUC2
49cork-handlers' disease9.9PSG2, MUC5AC
50inflammatory bowel disease9.9MUC2, MUC5AC

Graphical network of the top 20 diseases related to Ampulla of Vater Carcinoma:



Diseases related to ampulla of vater carcinoma

Symptoms for Ampulla of Vater Carcinoma

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Drugs & Therapeutics for Ampulla of Vater Carcinoma

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Drug clinical trials:

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Genetic Tests for Ampulla of Vater Carcinoma

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Anatomical Context for Ampulla of Vater Carcinoma

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MalaCards organs/tissues related to Ampulla of Vater Carcinoma:

32
Liver, Lymph node

Animal Models for Ampulla of Vater Carcinoma or affiliated genes

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Publications for Ampulla of Vater Carcinoma

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Articles related to Ampulla of Vater Carcinoma:

(show all 13)
idTitleAuthorsYear
1
Clinical value of serum CA19-9 as a prognostic factor for the ampulla of Vater carcinoma. (23933785)
2013
2
Proposed indications for limited resection of early ampulla of Vater carcinoma: clinico-histopathological criteria to confirm cure. (22203456)
2012
3
Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (20838624)
2010
4
Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma. (20698243)
2010
5
Spontaneous choledochoduodenal fistula after metallic biliary stent placement in a patient with ampulla of vater carcinoma. (20431778)
2009
6
Determinants of long-term survival after pancreaticoduodenectomy for ampulla of Vater carcinoma]. (20223115)
2009
7
Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma. (18712568)
2008
8
Transduodenal local resection for low-risk group ampulla of vater carcinoma. (18158802)
2007
9
Periampullary choledochoduodenal fistula associated with ampulla of Vater carcinoma. (17404887)
2007
10
Factors influencing recurrence after curative resection for ampulla of Vater carcinoma. (17326125)
2007
11
The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis. (18019683)
2007
12
Clinics in diagnostic imaging (79). Ampulla of Vater carcinoma. (12680532)
2002
13
Prognostic value of MIB-1 index and DNA ploidy in resectable ampulla of Vater carcinoma. (10203085)
1999

Variations for Ampulla of Vater Carcinoma

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Expression for genes affiliated with Ampulla of Vater Carcinoma

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Expression patterns in normal tissues for genes affiliated with Ampulla of Vater Carcinoma

Search GEO for disease gene expression data for Ampulla of Vater Carcinoma.

Pathways for genes affiliated with Ampulla of Vater Carcinoma

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Pathways related to Ampulla of Vater Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.4MUC5AC, MUC2
2
Show member pathways
9.4MUC5AC, MUC2

Compounds for genes affiliated with Ampulla of Vater Carcinoma

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Compounds related to Ampulla of Vater Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1cesium chloride44 6110.6MUC5AC, MUC2
2carbohydrates449.5MUC5AC, MUC2
3dmso449.4MUC2, MUC5AC
4pd 98,059449.4MUC2, MUC5AC
5methotrexate50 44 1111.3MUC2, MUC5AC
6sb 20358044 6110.1MUC2, MUC5AC
7hematoxylin449.1MUC2, MUC5AC, PSG2
8sialic acid449.0MUC2, MUC5AC, PSG2
95fluorouracil449.0MUC5AC, MUC2, PSG2
10paraffin449.0MUC2, PSG2, MUC5AC
11glucose448.9MUC2, MUC5AC, PSG2
12estrogen448.8MUC2, MCRS1, MUC5AC

GO Terms for genes affiliated with Ampulla of Vater Carcinoma

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Cellular components related to Ampulla of Vater Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.4MUC5AC, MUC2

Biological processes related to Ampulla of Vater Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1post-translational protein modificationGO:0436879.4MUC5AC, MUC2
2O-glycan processingGO:0162669.1MUC5AC, MUC2

Products for genes affiliated with Ampulla of Vater Carcinoma

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Sources for Ampulla of Vater Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet