MCID: AMP010
MIFTS: 37

Ampulla of Vater Carcinoma malady

Cancer diseases, Liver diseases, Rare diseases categories
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Summaries for Ampulla of Vater Carcinoma

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33MalaCards
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MalaCards: Ampulla of Vater Carcinoma, also known as carcinoma of ampulla of vater, is related to adenocarcinoma and adenosquamous carcinoma. An important gene associated with Ampulla of Vater Carcinoma is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are NOD-like Receptor Signaling Pathways and O-linked glycosylation of mucins. The compounds cesium chloride and carbohydrates have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node.

Aliases & Classifications for Ampulla of Vater Carcinoma

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8Disease Ontology, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

49
ampullary carcinoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

ampulla of vater carcinoma 8 10
carcinoma of ampulla of vater 8 62
ampullary carcinoma 8 49
carcinoma of the ampulla of vater 49
tumor of the ampulla of vater 8
ampulla of vater neoplasm 8
ampulla of vater cancer 8
ampulloma 49


External Ids:

Disease Ontology8 DOID:4932, DOID:10022
NCIt40 C3908, C4443
SNOMED-CT via Orphanet59 254609000
UMLS via Orphanet63 C0262401
ICD10 via Orphanet26 C24.1
ICD1025 C24.1

Related Diseases for Ampulla of Vater Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Ampulla of Vater Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7MUC2, MUC5AC, PSG2
2adenosquamous carcinoma30.6MUC5AC, MUC2
3cholangiocarcinoma30.4PSG2, MUC5AC, MUC2
4adenoma30.4MUC2, MUC5AC, PSG2
5gallbladder cancer30.1MUC5AC, MUC2
6bladder carcinoma30.1PSG2, MUC2
7neuroendocrine carcinoma10.8
8large cell neuroendocrine carcinoma10.6
9gastrointestinal stromal tumor10.6
10small cell neuroendocrine carcinoma10.4
11acinar cell carcinoma10.4
12desmoid tumor10.4
13fibromatosis10.4
14duodenal ulcer10.4
15acalculous cholecystitis10.4
16obstructive jaundice10.4
17cholecystitis10.4
18neuroendocrine tumor10.4
19adenocarcinoid tumor10.4
20aneurysmal bone cysts10.4
21inflammatory myofibroblastic tumor10.4
22aneurysm10.4
23endotheliitis10.4
24pancreatitis10.3
25duodenitis10.2
26annular pancreas10.2
27biliary papillomatosis10.1MUC2
28situs inversus10.1
29intrahepatic cholangiocarcinoma10.1
30spondyloarthropathy10.1
31microinvasive gastric cancer10.0PSG2, MUC2
32laryngeal benign neoplasm10.0MUC2, PSG2
33pseudomyxoma peritonei10.0MUC5AC, MUC2
34papilloma10.0MUC2, MUC5AC
35pancreatic ductal carcinoma10.0MUC5AC, MUC2
36cystadenocarcinoma10.0MUC2, MUC5AC
37bronchiolo-alveolar adenocarcinoma10.0MUC2, MUC5AC
38tubular adenocarcinoma10.0MUC5AC, MUC2
39respiratory failure10.0MUC2, MUC5AC
40factor vii deficiency10.0MUC5AC, PSG2
41barrett's esophagus10.0MUC5AC, MUC2
42pancreatic cancer10.0MUC5AC, MUC2
43familial adenomatous polyposis10.0MUC5AC, MUC2
44pulmonary disease, chronic obstructive10.0MUC5AC, MUC2
45colon adenocarcinoma10.0MUC5AC, MUC2
46cork-handlers' disease10.0PSG2, MUC5AC
47inflammatory bowel disease10.0MUC5AC, MUC2
48lung cancer10.0PSG2, MUC5AC
49mucoepidermoid carcinoma10.0PSG2, MUC5AC, MUC2
50pancreatitis, chronic10.0MUC2, MUC5AC, PSG2

Graphical network of the top 20 diseases related to Ampulla of Vater Carcinoma:



Diseases related to ampulla of vater carcinoma

Symptoms for Ampulla of Vater Carcinoma

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Drugs & Therapeutics for Ampulla of Vater Carcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Ampulla of Vater Carcinoma

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Anatomical Context for Ampulla of Vater Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Ampulla of Vater Carcinoma:

33
Liver, Lymph node

Animal Models for Ampulla of Vater Carcinoma or affiliated genes

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Publications for Ampulla of Vater Carcinoma

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52PubMed
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Articles related to Ampulla of Vater Carcinoma:

(show all 13)
idTitleAuthorsYear
1
Clinical value of serum CA19-9 as a prognostic factor for the ampulla of Vater carcinoma. (23933785)
2013
2
Proposed indications for limited resection of early ampulla of Vater carcinoma: clinico-histopathological criteria to confirm cure. (22203456)
2012
3
Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (20838624)
2010
4
Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma. (20698243)
2010
5
Spontaneous choledochoduodenal fistula after metallic biliary stent placement in a patient with ampulla of vater carcinoma. (20431778)
2009
6
Determinants of long-term survival after pancreaticoduodenectomy for ampulla of Vater carcinoma]. (20223115)
2009
7
Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma. (18712568)
2008
8
Transduodenal local resection for low-risk group ampulla of vater carcinoma. (18158802)
2007
9
Periampullary choledochoduodenal fistula associated with ampulla of Vater carcinoma. (17404887)
2007
10
Factors influencing recurrence after curative resection for ampulla of Vater carcinoma. (17326125)
2007
11
The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis. (18019683)
2007
12
Clinics in diagnostic imaging (79). Ampulla of Vater carcinoma. (12680532)
2002
13
Prognostic value of MIB-1 index and DNA ploidy in resectable ampulla of Vater carcinoma. (10203085)
1999

Variations for Ampulla of Vater Carcinoma

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Expression for genes affiliated with Ampulla of Vater Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ampulla of Vater Carcinoma

Search GEO for disease gene expression data for Ampulla of Vater Carcinoma.

Pathways for genes affiliated with Ampulla of Vater Carcinoma

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50PathCards, 54R&D Systems, 60Thomson Reuters, 55Reactome, 30KEGG
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Pathways related to Ampulla of Vater Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.4MUC5AC, MUC2
2
Show member pathways
9.4MUC5AC, MUC2

Compounds for genes affiliated with Ampulla of Vater Carcinoma

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45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank
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Compounds related to Ampulla of Vater Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1cesium chloride45 6110.6MUC5AC, MUC2
2carbohydrates459.5MUC5AC, MUC2
3dmso459.4MUC2, MUC5AC
4pd 98,059459.4MUC2, MUC5AC
5methotrexate51 45 1111.3MUC2, MUC5AC
6sb 20358045 6110.1MUC2, MUC5AC
7hematoxylin459.1MUC2, MUC5AC, PSG2
8sialic acid459.0MUC2, MUC5AC, PSG2
95fluorouracil459.0MUC5AC, MUC2, PSG2
10paraffin459.0MUC2, PSG2, MUC5AC
11glucose458.9MUC2, MUC5AC, PSG2
12estrogen458.8MUC2, MCRS1, MUC5AC

GO Terms for genes affiliated with Ampulla of Vater Carcinoma

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16Gene Ontology
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Cellular components related to Ampulla of Vater Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.4MUC5AC, MUC2

Biological processes related to Ampulla of Vater Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1post-translational protein modificationGO:0436879.4MUC5AC, MUC2
2O-glycan processingGO:0162669.1MUC5AC, MUC2

Products for genes affiliated with Ampulla of Vater Carcinoma

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Sources for Ampulla of Vater Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet