MCID: AMP003
MIFTS: 39

Ampulla of Vater Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Ampulla of Vater Neoplasm

MalaCards integrated aliases for Ampulla of Vater Neoplasm:

Name: Ampulla of Vater Neoplasm 12 14
Carcinoma of Ampulla of Vater 12 69
Ampulla of Vater Carcinoma 12 14
Ampullary Carcinoma 12 55
Carcinoma of the Ampulla of Vater 55
Tumor of the Ampulla of Vater 12
Neoplasm of Ampulla of Vater 69
Ampulla of Vater Cancer 12
Ampulloma 55

Characteristics:

Orphanet epidemiological data:

55
carcinoma of the ampulla of vater
Inheritance: Not applicable; Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:10022 DOID:4932
NCIt 46 C4443 C3908
SNOMED-CT 64 126858004 254609000
Orphanet 55 ORPHA300557
UMLS via Orphanet 70 C0262401
ICD10 via Orphanet 33 C24.1
ICD10 32 C24.1

Summaries for Ampulla of Vater Neoplasm

Disease Ontology : 12 An ampulla of Vater cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

MalaCards based summary : Ampulla of Vater Neoplasm, also known as carcinoma of ampulla of vater, is related to ampulla of vater adenocarcinoma and adenosquamous carcinoma. An important gene associated with Ampulla of Vater Neoplasm is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Gastric cancer and O-linked glycosylation. The drugs Pancrelipase and pancreatin have been mentioned in the context of this disorder. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ampulla of Vater Neoplasm

Diseases related to Ampulla of Vater Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 ampulla of vater adenocarcinoma 30.6 CDX2 KRT17 KRT20 KRT7 MUC1 MUC2
2 adenosquamous carcinoma 30.5 KRAS KRT7 MUC1
3 cholecystitis 30.1 MUC1 MUC2 MUC6
4 neuroendocrine tumor 29.7 KRT20 KRT7 SST
5 adenoma 29.7 KRAS KRT7 MUC2 SST
6 ampulla of vater squamous cell carcinoma 11.2
7 ampulla of vater adenosquamous carcinoma 11.2
8 sigmoid neoplasm 10.5 HRAS KRAS
9 schimmelpenning-feuerstein-mims syndrome 10.5 HRAS KRAS
10 paronychia 10.5 HRAS KRAS
11 bile duct cysts 10.5 HRAS KRAS
12 secondary hypertrophic osteoarthropathy 10.5 HRAS KRAS
13 nevus, epidermal 10.5 HRAS KRAS
14 lung adenoid cystic carcinoma 10.4 HRAS KRAS
15 ovary serous adenocarcinoma 10.4 HRAS KRAS
16 syringocystadenoma papilliferum 10.4 KRAS MUC1
17 mucinous intrahepatic cholangiocarcinoma 10.4 CDX2 MUC2
18 ovarian cystadenocarcinoma 10.4 HRAS KRAS
19 middle ear adenoma 10.4 KRT7 MUC1
20 pulmonic stenosis 10.4 HRAS KRAS
21 endosalpingiosis 10.4 KRT7 MUC1
22 acneiform dermatitis 10.4 HRAS KRAS
23 parachordoma 10.4 KRT7 MUC1
24 malignant mixed mullerian tumor 10.4 KRT7 MUC1
25 nodular hidradenoma 10.4 KRT7 MUC1
26 mucinous adenofibroma 10.4 CDX2 KRT7
27 eccrine porocarcinoma 10.4 KRT7 MUC1
28 apocrine adenocarcinoma 10.4 KRT7 MUC1
29 monophasic synovial sarcoma 10.4 KRT7 MUC1
30 nephrogenic adenoma 10.4 KRT7 MUC1
31 chronic cholangitis 10.4 CDX2 MUC2
32 epithelial predominant wilms' tumor 10.4 CDX2 KRT7
33 hidradenoma 10.3 KRT7 MUC1
34 well-differentiated liposarcoma 10.3 KRT7 MUC1
35 microinvasive gastric cancer 10.3 CDX2 MUC2
36 clear cell basal cell carcinoma 10.3 KRT17 KRT7
37 endocervical carcinoma 10.3 KRT7 MUC6
38 cystic basal cell carcinoma 10.3 KRT20 KRT7
39 sertoli-leydig cell tumor 10.3 KRT7 MUC1
40 hepatoid adenocarcinoma 10.3 CDX2 MUC1
41 adenosquamous cell lung carcinoma 10.3 HRAS KRAS
42 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 CDX2 MUC2
43 microcystic adenoma 10.3 MUC1 MUC6
44 lung acinar adenocarcinoma 10.3 KRT20 KRT7
45 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
46 transverse colon cancer 10.3 KRT20 KRT7
47 spindle cell sarcoma 10.3 KRT7 MUC1
48 ovarian large-cell neuroendocrine carcinoma 10.3 KRT20 KRT7
49 eyelid neoplasm 10.3 KRT20 KRT7
50 krukenberg carcinoma 10.3 KRT20 KRT7

Graphical network of the top 20 diseases related to Ampulla of Vater Neoplasm:



Diseases related to Ampulla of Vater Neoplasm

Symptoms & Phenotypes for Ampulla of Vater Neoplasm

GenomeRNAi Phenotypes related to Ampulla of Vater Neoplasm according to GeneCards Suite gene sharing:

25 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.74 KRT17
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.74 KRAS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.74 KRAS
4 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.74 KRT17
5 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.74 KRAS
6 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.74 KRT17
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.74 KRAS
8 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.74 HRAS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.74 KRT17
10 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.74 HRAS KRAS KRT17
11 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.74 KRT17
12 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.74 KRT17
13 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.74 KRAS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.74 KRAS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.74 KRT17
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.74 HRAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.74 KRT17
18 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.74 KRT17
19 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.74 KRT17 KRAS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.74 KRAS
21 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.74 KRAS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.74 HRAS
23 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.74 KRAS
24 Decreased viability GR00055-A-2 9.7 HRAS MUC1 KRAS
25 Decreased viability GR00106-A-0 9.7 KRAS
26 Decreased viability GR00221-A-1 9.7 HRAS KRAS
27 Decreased viability GR00221-A-2 9.7 HRAS KRAS
28 Decreased viability GR00221-A-3 9.7 HRAS
29 Decreased viability GR00301-A 9.7 KRAS
30 Decreased viability GR00381-A-1 9.7 KRAS

MGI Mouse Phenotypes related to Ampulla of Vater Neoplasm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 CDX2 HRAS KRAS KRT17 MUC2 SST

Drugs & Therapeutics for Ampulla of Vater Neoplasm

Drugs for Ampulla of Vater Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 3 53608-75-6
2 pancreatin Phase 3
3 Cola Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reduced Pancreatic Fistula Rate Following Pancreaticoduodenectomy: Trial on Pancreaticogastrostomy Versus Pancreaticojejunostomy Completed NCT00830778 Phase 3
2 Endoscopic Papillectomy for Early Ampullary Tumors: Long-term Results of the First Large Multicenter Prospective Study Completed NCT01764503
3 Endoscopic Ultrasound Staging of Periampullary Neoplasms: Retrospective Completed NCT00880633
4 Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation Completed NCT02477228
5 Perioperative Cancer Cell Dissemination and Systemic Immune Suppression in Resectable Ductal Pancreatic Adenocarcinoma Completed NCT00495924
6 Loop-tipped Guidewire in Selective Biliary Cannulation Completed NCT02028845
7 Clinical Outcomes of the Endoscopic Resection of Premalignant and Malignant Gastrointestinal Lesions Recruiting NCT01750619
8 Surgery for Pancreatic Tumors and Collection of Tumor Tissue for Study Terminated NCT00100321
9 Reduced Intra-operative Blood Loss in Pancreaticoduodenectomy for Pancreatic or Peri-ampullary Tumors; Monocentric Trial on Standard Open Versus Minimally Invasive Surgery Withdrawn NCT01712971

Search NIH Clinical Center for Ampulla of Vater Neoplasm

Genetic Tests for Ampulla of Vater Neoplasm

Anatomical Context for Ampulla of Vater Neoplasm

Publications for Ampulla of Vater Neoplasm

Articles related to Ampulla of Vater Neoplasm:

# Title Authors Year
1
Adenosquamous Carcinoma of Ampulla of Vater-a Case Report with Review of Literature. ( 26411563 )
2015
2
Primary adenosquamous carcinoma of ampulla of Vater-A rare case report. ( 24879329 )
2014
3
Prognostic significance of vascular endothelial growth factor expression and microvessel density in carcinoma of ampulla of Vater. ( 16506374 )
2006

Variations for Ampulla of Vater Neoplasm

Expression for Ampulla of Vater Neoplasm

Search GEO for disease gene expression data for Ampulla of Vater Neoplasm.

Pathways for Ampulla of Vater Neoplasm

Pathways related to Ampulla of Vater Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 CDX2 HRAS KRAS MUC2
2
Show member pathways
11.93 MUC1 MUC2 MUC6
3 11.75 KRT17 KRT20 KRT7 MUC1
4
Show member pathways
11.66 MUC1 MUC2 MUC6
5
Show member pathways
11.43 HRAS KRAS MUC1 MUC2 MUC6
6
Show member pathways
11.37 MUC1 MUC2 MUC6
7 11.01 HRAS KRAS
8 11 HRAS KRAS
9
Show member pathways
10.97 HRAS KRAS
10
Show member pathways
10.89 HRAS KRAS
11 10.82 HRAS KRAS
12 10.78 HRAS KRAS
13 10.67 HRAS KRAS
14 10.37 HRAS KRAS

GO Terms for Ampulla of Vater Neoplasm

Cellular components related to Ampulla of Vater Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT17 KRT20 KRT7
2 Golgi lumen GO:0005796 8.8 MUC1 MUC2 MUC6

Biological processes related to Ampulla of Vater Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.61 KRT17 KRT20 KRT7
2 cornification GO:0070268 9.5 KRT17 KRT20 KRT7
3 regulation of long-term neuronal synaptic plasticity GO:0048169 9.4 HRAS KRAS
4 intermediate filament organization GO:0045109 9.37 KRT17 KRT20
5 maintenance of gastrointestinal epithelium GO:0030277 9.26 MUC2 MUC6
6 response to isolation stress GO:0035900 9.16 HRAS KRAS
7 O-glycan processing GO:0016266 9.13 MUC1 MUC2 MUC6
8 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 HRAS KRAS MUC1 MUC2 MUC6

Sources for Ampulla of Vater Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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