Amyloid Neuropathy malady

MalaCards: Amyloid Neuropathy, also known as amyloid neuropathies, is related to alzheimer's disease and amyloidosis. An important gene associated with Amyloid Neuropathy is TTR (transthyretin), and among its related pathways is Ca, cAMP and Lipid Signaling. The compounds thioflavin t and trifluoroethanol have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotype homeostasis/metabolism.

amyloid neuropathy 7 30 amyloid neuropathies 32 43

amyloid deposition 43 neuropathy amyloid 30

Diseases related to amyloid neuropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 74)

id	Related Disease	Score	Top Affiliating Genes
1	alzheimer's disease	32.3	APOA1, TTR, MPZ, GSN
2	amyloidosis	32.2	TTR, APOA1, GSN
3	neuropathy	31.2	TTR, GSN, APOA1, MPZ
4	cerebral amyloid angiopathy	30.2	GSN, TTR
5	polyneuropathy	30.0	GSN, TTR, MPZ, APOA1
6	dementia	29.5	APOA1, TTR, GSN
7	familial transthyretin amyloidosis	28.2	GSN, TTR, APOA1
8	amyloid tumor	28.1	GSN, TTR
9	lattice corneal dystrophy type ii	28.1	GSN, TTR
10	familial mediterranean fever	27.5	GSN, APOA1
11	hereditary amyloidosis	27.0	TTR, GSN, APOA1
12	autoimmune disease of central nervous system	12.5	TTR, APOA1
13	amyloidosis, renal	12.5	APOA1, TTR
14	avascular necrosis of femoral head	12.5	APOA1, TTR
15	amyloidosis, secondary	12.5	APOA1, TTR
16	takayasu's arteritis	12.4	APOA1, TTR
17	amenorrhea	12.4	APOA1, TTR
18	tremor	12.4	APOA1, MPZ
19	retinol binding protein	12.4	TTR, APOA1
20	arteriosclerosis	12.3	APOA1, TTR
21	hyperhomocysteinemia	12.2	APOA1, TTR
22	tetanus	12.2	GSN, MPZ
23	glucose intolerance	12.2	TTR, APOA1
24	mayer-rokitansky-kuster-hauser syndrome	12.2	GSN, TTR, MPZ
25	uremia	12.1	TTR, APOA1
26	gestational diabetes	12.1	TTR, APOA1
27	hearing loss	12.1	MPZ, GSN, TTR
28	paralysis	12.0	GSN, MPZ
29	autonomic dysfunction	11.9	GSN, APOA1, TTR
30	inclusion body myositis	11.9	GSN, APOA1, TTR
31	myositis	11.9	TTR, GSN, APOA1
32	nephrotic syndrome	11.9	TTR, GSN, APOA1
33	noonan syndrome	11.7	TTR, GSN, APOA1
34	myocardial infarction	11.7	APOA1, TTR, GSN
35	peripheral neuropathy	11.4	MPZ, GSN, TTR, APOA1
36	gonococcal synovitis	11.3	APOA1, MPZ, TTR, GSN
37	cerebritis	8.6
38	gerstmann-straussler-scheinker disease	7.9
39	neuronitis	7.9
40	carcinoma	7.0
41	carpal tunnel syndrome	7.0
42	down syndrome	7.0
43	finnish type amyloidosis	7.0
44	lattice corneal dystrophy type 1	7.0
45	pancreatitis	7.0
46	lattice corneal dystrophy	6.9
47	transthyretin amyloidosis	6.9
48	epidermolysis bullosa	6.1
49	hyperglycemia	6.1
50	insulin resistance	6.1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to amyloid neuropathy:

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MGI Mouse Phenotypes related to amyloid neuropathy:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	8.0	MPZ, GSN, APOA1, TTR

Articles related to amyloid neuropathy:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	Amyloid neuropathy with transthyretin mutations: over view and unique Ala97Ser in Taiwan. (21739396)	Hsieh S.T.	2011	TTR
2	Poor outcome after liver transplantation for transthy retin amyloid neuropathy in a family with an Ala36Pro transthyretin mutation: c ase report. (20373457)	Muller K.R.... Harley H.A.	2010	TTR
3	Usefulness of combined nerve and muscle biopsy in the diagnosis of amyloid neuropathy--a study of 6 new cases. (20175953)	Vital C.... Vital A.	2010	TTR
4	Progression of transthyretin amyloid neuropathy after liver transplantation. (20660862)	Liepnieks J.J.... Benson M.D.	2010	TTR
5	Amyloid neuropathy resulting from an unknown protein (18584922)	Younsi R.... Kissani N.	2009	TTR
6	Axonal neuropathy due to myelin protein zero mutation misdiagnosed as amyloid neuropathy. (18563718)	Briani C.... Fabrizi G.	2008	MPZ
7	The molecular biology and clinical features of amyloid neuropathy. (17554795)	Benson M.D.... Kincaid J.C.	2007	TTR
8	Familial amyloid neuropathy associated with the Cys114 mutation of the transthyretin gene in a Russian family (18688962)	Strokov I.A.... Koval'chuk M.O.	2007	TTR
9	Genetic study of transthyretin amyloid neuropathies: carrier risks among French and Portuguese families. (14627687)	PlantAc-Bordeneuve V.... BonaA^ti-PelliAc C.	2003	TTR
10	Two pairs of proven monozygotic twins discordant for familial amyloid neuropathy (FAP) TTR Met 30. (10465115)	Munar-Ques M.... Sequeiros J.	1999	TTR
11	Ultrastructural immunolabelling of amyloid fibrils in acquired and hereditary amyloid neuropathies. (8869389)	Adams D.... Said G.	1996	TTR
12	Immunoassay for transthyretin variants associated with amyloid neuropathy. (8394031)	Costa P.M.... Costa P.P.	1993	TTR
13	Transthyretin gene mutations in British and French patients with amyloid neuropathy. (8509786)	Bhatia K.... Harding A.E.	1993	TTR
14	Demonstration of genetic mutation in most of the amyloid neuropathies with sporadic occurrence (1338934)	Adams D.... Said G.	1992	TTR

Genes related to amyloid neuropathy according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	TTR	transthyretin	11.0	Publications
2	GSN	gelsolin	11.0
3	APOA1	apolipoprotein A-I	11.0
4	MPZ	myelin protein zero	11.0	Publications

Pathways related to amyloid neuropathy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Ca, cAMP and Lipid Signaling3	9.0	GSN, APOA1

Compounds related to amyloid neuropathy according to GeneDecks:

(show all 26)

id	Compound	Score	Top Affiliating Genes
1	thioflavin t32	9.7	TTR, GSN
2	trifluoroethanol32 9 9	11.7	TTR, GSN
3	retinyl palmitate32 18	10.5	APOA1, TTR
4	tocopherol32	9.5	APOA1, TTR
5	mspi32	9.5	APOA1, TTR
6	sodium dodecylsulfate32	9.4	GSN, TTR
7	guanidine32 9 18 9	12.4	TTR, APOA1
8	25-hydroxyvitamin d32	9.4	APOA1, TTR
9	vitamin b1232	9.4	APOA1, TTR
10	guanidine hydrochloride32	9.4	APOA1, TTR
11	uric acid32 18	10.3	APOA1, TTR
12	carnitine32	9.3	APOA1, TTR
13	alpha tocopherol32	9.3	TTR, APOA1
14	dihydrotestosterone32 9 18 9	12.2	MPZ, GSN
15	homocysteine32 18	10.2	APOA1, TTR
16	methionine32	9.2	MPZ, GSN, TTR
17	creatinine32	8.9	TTR, APOA1, MPZ
18	fibrinogen32	8.8	GSN, APOA1, TTR
19	thyroxine32 18	9.8	APOA1, TTR
20	cholesterol32 9 18 9	11.8	TTR, APOA1, MPZ
21	testosterone32 9 18 9	11.8	GSN, APOA1, TTR
22	alanine32	8.5	TTR, APOA1, GSN
23	retinoic acid32 42 18	10.5	GSN, APOA1, TTR
24	aspartate32	8.4	MPZ, GSN, APOA1, TTR
25	glutamate32	8.4	MPZ, GSN, APOA1, TTR
26	serine32	8.3	MPZ, GSN, APOA1, TTR

Cellular components related to amyloid neuropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.5	GSN, APOA1, TTR