MCID: AMY005
MIFTS: 32

Amyloid Neuropathy malady

Neuronal category

Summaries for Amyloid Neuropathy

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33MalaCards
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MalaCards: Amyloid Neuropathy, also known as amyloid neuropathies, is related to familial transthyretin amyloidosis and amyloidosis. An important gene associated with Amyloid Neuropathy is TTR (transthyretin), and among its related pathways are Visual phototransduction and FOXA2 and FOXA3 transcription factor networks. The compounds thioflavin t and trifluoroethanol have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and liver, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Amyloid Neuropathy

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

amyloid neuropathy 43
amyloid neuropathies 45 61
neuropathy amyloid 43


Related Diseases for Amyloid Neuropathy

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amyloid Neuropathy:



Diseases related to amyloid neuropathy

Clinical Features for Amyloid Neuropathy

Drugs & Therapeutics for Amyloid Neuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Amyloid Neuropathy

Drug clinical trials:

Search ClinicalTrials for Amyloid Neuropathy

Search NIH Clinical Center for Amyloid Neuropathy

Search CenterWatch for Amyloid Neuropathy

Genetic Tests for Amyloid Neuropathy

Anatomical Context for Amyloid Neuropathy

Sources:
33MalaCards
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MalaCards organs/tissues related to Amyloid Neuropathy:

33
Heart, Colon, Liver, Skin, Endothelial

Animal Models for Amyloid Neuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Amyloid Neuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0GSN, TTR, MPZ, APOA1

Publications for Amyloid Neuropathy

Sources:
51PubMed
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Articles related to Amyloid Neuropathy:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
TTR-related amyloid neuropathy: clinical, electrophysiological and pathological findings in 15 unrelated patients. (22592564)
2013
2
Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy. (24101130)
2013
3
Amyloid neuropathy mimicking chronic inflammatory demyelinating polyneuropathy. (22190302)
2012
4
Impact of aging on the progression of neuropathy after liver transplantation in transthyretin Val30Met amyloidosis. (23225390)
2012
5
Gastric emptying in hereditary transthyretin amyloidosis: the impact of autonomic neuropathy. (22897426)
2012
6
Mass spectrometric-based proteomic analysis of amyloid neuropathy type in nerve tissue. (20937937)
2011
7
Perspectives in refractory diabetic and amyloid small-fiber neuropathy. (22277460)
2011
8
Amyloid neuropathy in a younger domino liver transplanted recipient. (21319169)
2011
9
Usefulness of combined nerve and muscle biopsy in the diagnosis of amyloid neuropathy--a study of 6 new cases. (20175953)
2010
10
Stem cell transplantation in patients with autonomic neuropathy due to primary (AL) amyloidosis. (20231668)
2010
11
Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid polyneuropathy. (20132088)
2010
12
Acquired amyloid neuropathy in a Portuguese patient after domino liver transplantation. (20928908)
2010
13
Poor outcome after liver transplantation for transthyretin amyloid neuropathy in a family with an Ala36Pro transthyretin mutation: case report. (20373457)
2010
14
Quality of life following liver transplantation: a comparative study between Familial Amyloid Neuropathy and liver disease patients. (19604387)
2009
15
Hereditary amyloid neuropathy by transthyretin Val107 mutation in a patient of African origin. (18844793)
2008
16
Antibodies to myelin-associated glycoprotein (anti-Mag) in IgM amyloidosis may influence expression of neuropathy in rare patients. (18236455)
2008
17
The molecular biology and clinical features of amyloid neuropathy. (17554795)
2007
18
Hereditary amyloidosis with progressive peripheral neuropathy associated with apolipoprotein AI Gly26Arg: outcome of hepatorenal transplantation. (17600344)
2007
19
Combined heart and liver transplantation for familial amyloidotic neuropathy. (17449267)
2007
20
Severe ataxia with neuropathy in hereditary gelsolin amyloidosis: a case report. (17453628)
2007
21
Familial amyloid neuropathy associated with the Cys114 mutation of the transthyretin gene in a Russian family]. (18688962)
2007
22
Urinary dysfunction and autonomic control in amyloid neuropathy. (16477499)
2006
23
Iatrogenic amyloid neuropathy in a Japanese patient after sequential liver transplantation. (16889603)
2006
24
Gustatory sweating due to autonomic neuropathy in a patient with amyloidosis secondary to rheumatoid arthritis. (24387731)
2004
25
Amyloid neuropathy: a retrospective study of 35 peripheral nerve biopsies. (15574136)
2004
26
Amyloid neuropathy presenting as thoraco-abdominal parathesia. (11882067)
2002
27
Secondary amyloidosis as a life-ending event in multifocal motor neuropathy. (11562923)
2001
28
Sympathetic skin responses in hereditary sensory and autonomic neuropathy and familial amyloid neuropathy are different. (10454728)
1999
29
Colonic enteric nervous system in patients with familial amyloidotic neuropathy. (10412800)
1999
30
Amyloid neuropathy simulating lower motor neuron disease. (9710046)
1998
31
Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient. (10933463)
1998
32
Goitre and severe autonomic neuropathy due to secondary amyloidosis in a renal transplant patient. (8738674)
1996
33
Idiopathic AA amyloidosis manifested by autonomic neuropathy, vestibulocochleopathy, and lattice corneal dystrophy. (8201343)
1994
34
Transthyretin gene mutations in British and French patients with amyloid neuropathy. (8509786)
1993
35
Molecular genetics of amyloid neuropathy in Europe. (2564060)
1989
36
Pathophysiology of diarrhea in patients with familial amyloid neuropathy. (3493933)
1987
37
Cases with familiar amyloid neuropathy starting of the upper limbs and having hepatic disorder. (3041084)
1987
38
Amyloid neuropathy in a woman with tabes dorsalis. (6321985)
1984
39
Amyloid neuropathy: relationship between amyloid fibrils and macrophages. (6440326)
1984
40
Amyloid neuropathy in multiple myeloma and other plasma cell dyscrasias. A hypothesis of the pathogenesis of amyloid neuropathies. (6304257)
1983
41
Amyloid neuropathy and multiple myeloma. Ultrastructural and immunopathological study of two cases. (6301845)
1983
42
Posterior interosseous nerve paralysis and amyloid neuropathy of multiple myeloma. (7140071)
1982
43
The splanchnic autonomic outflow in amyloid neuropathy and Tangier disease. (7194438)
1981
44
Three forms of dominant amyloid neuropathy. (6975851)
1981
45
Portuguese-type amyloid neuropathy in an English family. (7465476)
1980
46
Amyloid neuropathy and tremor in WaldenstrAPm's macroglobulinemia. (6244806)
1980
47
Amyloid neuropathy due to monoclonal gammopathy. A case report. (72139)
1977
48
Femoral neuropathy and ischemic colitis associated with amyloidosis in hemodialysis patients. (1211994)
1975
49
Peripheral nerve changes in amyloid neuropathy. (4373122)
1974
50
Amyloid neuropathy; a clinical and pathological manifestation of primary atypical amyloidosis; with a case report. (13207912)
1954

Genetic Variations for Amyloid Neuropathy

Expression for genes affiliated with Amyloid Neuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyloid Neuropathy

Search GEO for disease gene expression data for Amyloid Neuropathy.

Pathways for genes affiliated with Amyloid Neuropathy

Sources:
54Reactome, 38NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Amyloid Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1APOA1, TTR
29.1APOA1, TTR
3
Hide members
9.1APOA1, TTR
49.0APOA1, GSN
58.5GSN, APOA1, TTR

Compounds for genes affiliated with Amyloid Neuropathy

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Amyloid Neuropathy according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1thioflavin t459.7GSN, TTR
2trifluoroethanol45 1110.7GSN, TTR
3retinyl palmitate45 2410.5APOA1, TTR
4sodium dodecylsulfate459.5TTR, GSN
5tocopherol459.5APOA1, TTR
6mspi459.5TTR, APOA1
7guanidine45 11 2411.5APOA1, TTR
825-hydroxyvitamin d459.4TTR, APOA1
9vitamin b12459.4TTR, APOA1
10guanidine hydrochloride459.4APOA1, TTR
11uric acid45 2410.4TTR, APOA1
12carnitine459.4APOA1, TTR
13alpha tocopherol459.3TTR, APOA1
14dihydrotestosterone45 29 11 2412.3MPZ, GSN
15homocysteine45 2410.2APOA1, TTR
16cysteine459.2GSN, MPZ
17methionine459.2GSN, MPZ, TTR
18thyroxine45 2410.1APOA1, TTR
19creatinine458.9TTR, MPZ, APOA1
20fibrinogen458.9APOA1, TTR, GSN
21cholesterol45 29 11 2411.9APOA1, MPZ, TTR
22testosterone45 60 11 2411.8GSN, TTR, APOA1
23alanine458.7TTR, APOA1, GSN
24retinoic acid45 249.6TTR, APOA1, GSN
25aspartate458.4GSN, TTR, MPZ, APOA1
26glutamate458.4APOA1, MPZ, TTR, GSN
27serine458.3MPZ, GSN, TTR, APOA1
28glucose458.2TTR, APOA1, GSN

GO Terms for genes affiliated with Amyloid Neuropathy

Sources:
16Gene Ontology
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Cellular components related to Amyloid Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5GSN, TTR, APOA1

Biological processes related to Amyloid Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phototransduction, visible lightGO:0076039.1TTR, APOA1
2retinoid metabolic processGO:0015238.8TTR, APOA1

Products for genes affiliated with Amyloid Neuropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amyloid Neuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet