MCID: AMY002
MIFTS: 35

Amyloid Tumor malady

Cancer diseases category

Summaries for Amyloid Tumor

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32MalaCards
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MalaCards: Amyloid Tumor, also known as amyloid deposition, is related to renal osteodystrophy and hyperparathyroidism. An important gene associated with Amyloid Tumor is CALCA (calcitonin-related polypeptide alpha), and among its related pathways is Packaging Of Telomere Ends. The compounds dmsa and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and pancreatic islet.

Aliases & Classifications for Amyloid Tumor

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

amyloid tumor 8 60
amyloid deposition 60
amyloid neoplasm 8


External Ids:

Disease Ontology8 DOID:6755
SNOMED-CT56 37279009

Related Diseases for Amyloid Tumor

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amyloid Tumor:



Diseases related to amyloid tumor

Clinical Features for Amyloid Tumor

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Drugs & Therapeutics for Amyloid Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Amyloid Tumor

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Anatomical Context for Amyloid Tumor

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32MalaCards
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MalaCards organs/tissues related to Amyloid Tumor:

32
Breast, Lung, Pancreatic islet, Trachea, Tongue, Monocytes, Skin, Thyroid, Prostate, Pancreas, B cells, Endothelial, Adipocyte, Brain, Spleen

Animal Models for Amyloid Tumor or affiliated genes

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Publications for Amyloid Tumor

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50PubMed
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Articles related to Amyloid Tumor:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Clinical significance of amyloid precursor protein in patients with testicular germ cell tumor. (23662100)
2013
2
Combination of plasma tumor necrosis factor receptors signaling proteins, beta-amyloid and apolipoprotein E for the detection of Alzheimer's disease. (23500026)
2013
3
Prostate amyloid tumor is a clue leading to the diagnosis of systemic AL amyloidosis. (23826754)
2013
4
Psammoma bodies and abundant stromal amyloid in an endoscopic ultrasound guided fine needle aspirate (EUS-FNA) of a pancreatic neuroendocrine tumor: A potential pitfall. (23447372)
2013
5
Serum amyloid a is associated with obesity and estrogen receptor-negative tumors in postmenopausal women with breast cancer. (23300020)
2013
6
Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors. (21056685)
2011
7
Expression of serum amyloid a in human ovarian epithelial tumors: implication for a role in ovarian tumorigenesis. (20713982)
2010
8
Amyloid tumor of the stomach simulating an obstructing gastric carcinoma: case report and review of the literature. (19288419)
2009
9
Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes. (19862700)
2009
10
Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells. (18695905)
2008
11
Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons. (15837568)
2005
12
Aspiration cytology diagnosis of a primary amyloid tumor of thoracic vertebra: a case report. (15282731)
2004
13
Serum amyloid A-induced mRNA expression and release of tumor necrosis factor-alpha (TNF-alpha) in human neutrophils. (14757367)
2004
14
Amyloid tumor of the larynx associated with plasma cell infiltration: differential diagnosis. (15724743)
2004
15
Amyloid tumor: a clinical and cytomorphologic study. (12768639)
2003
16
Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35). (12478619)
2003
17
AA-type amyloid tumor as an unsuspected cause of residual mass in a patient with large B-cell non-Hodgkin's lymphoma. (12002783)
2002
18
Antioxidants inhibit the human cortical neuron apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42. (12592670)
2002
19
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. (11939793)
2002
20
Aspiration biopsy findings in amyloid tumor of the cervical vertebra. A case report. (11393073)
2001
21
Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. (10713108)
2000
22
Localized amyloid tumor in small bowel. (11052330)
2000
23
The amyloid deposit in calcifying epithelial odontogenic tumor is immunoreactive for cytokeratins. (10835524)
2000
24
A choroidal amyloid-rich neuroendocrine tumor: initial manifestation of Cushing syndrome. (10448755)
1999
25
Amyloid-beta peptide induced inflammatory reaction is mediated by the cytokines tumor necrosis factor and interleukin-1. (10626000)
1999
26
Primary amyloid tumor (amyloidoma) of the jejunum with spheroid type of amyloid. (10212914)
1999
27
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. (9774383)
1998
28
Tumor necrosis factor alpha augments amyloid beta protein (25-35) induced apoptosis in human cells. (9464644)
1997
29
Recurrent amyloid tumor of the parotid gland. (7536425)
1995
30
Amyloid tumor of the sacrum. A case report. (7762341)
1995
31
Atypical carcinoid tumor of the lung with amyloid stroma. (1609616)
1992
32
Localized primary amyloid tumor of the thyroid developing in the course of Hashimoto's thyroiditis. (1570743)
1992
33
Islet amyloid polypeptide and calcitonin gene-related peptide immunoreactivity in amyloid and tumor cells of canine pancreatic endocrine tumors. (1972303)
1990
34
Craniocervical amyloid tumor with destructive spondyloarthropathy and myelocompression as a rare complication of long-term dialysis]. (2108522)
1990
35
Subcutaneous amyloid-tumor of beta-2-microglobulin origin in a long-term hemodialysis patient. (2674745)
1989
36
Amyloid tumor of the spleen. (3307463)
1987
37
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations. (3526931)
1986
38
Pulmonary amyloid nodule simulating pancoast tumor. (6725379)
1984
39
Primary amyloid tumor of the lacrimal gland: CT findings. (6630639)
1983
40
Case report 233. Amyloid tumor of the sternum as part of a solitary plasmacytoma. (6879219)
1983
41
Amyloid tumor. A clinicopathologic study of four cases. (148847)
1978
42
Case report. Localized amyloid tumor of the bladder presenting as an anterior pelvic mass. (1155740)
1975
43
Intrasellar amyloid tumor. (4114837)
1972
44
Calcifying epithelial odontogenic tumor: an amyloid-producing neoplasm. (5246781)
1968
45
Amyloid tumor of the conjunctiva and eyelid. (5977080)
1966
46
SOLITARY AMYLOID TUMOR OF THE LUNG. A CASE REPORT. (14277508)
1965
47
Amyloid tumor of the gasserian ganglion; report of case. (13429403)
1957
48
Plasma cell myeloma of vertebrae with amyloid tumor, producing paraplegia; report of a case. (13195999)
1954
49
Amyloid tumor of the larynx requiring laryngofissure. (18112660)
1949
50
Amyloid tumor of the bladder. (18124130)
1949

Genetic Variations for Amyloid Tumor

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Expression for genes affiliated with Amyloid Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyloid Tumor

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Pathways for genes affiliated with Amyloid Tumor

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53Reactome
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Pathways related to Amyloid Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1B2M, CALCA

Compounds for genes affiliated with Amyloid Tumor

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Amyloid Tumor according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1dmsa449.5B2M, CALCA
2calcium carbonate449.4B2M, CALCA
3pamidronate44 49 1111.4CALCA, B2M
4pmma449.4B2M, CALCA
525-hydroxyvitamin d449.4CALCA, B2M
6nitroglycerin44 1110.4CALCA, B2M
7phosphorus449.4B2M, CALCA
8fluoride449.4B2M, CALCA
9captopril44 28 49 59 1113.4B2M, CALCA
10vincristine44 49 1111.3CALCA, B2M
11thyroxine44 2410.3B2M, CALCA
12calcitriol44 59 11 2412.3B2M, CALCA
13indomethacin44 59 28 1112.2B2M, CALCA
14vitamin d449.2CALCA, B2M
15cyclosporin a44 28 5911.1B2M, CALCA
16creatinine449.1B2M, CALCA
17pge2449.0B2M, CALCA
18lactate448.8B2M, CALCA

GO Terms for genes affiliated with Amyloid Tumor

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16Gene Ontology
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Molecular functions related to Amyloid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1B2M, CALCA

Products for genes affiliated with Amyloid Tumor

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  • Antibodies
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Sources for Amyloid Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet