MCID: AMY002
MIFTS: 35

Amyloid Tumor malady

Cancer category

Summaries for Amyloid Tumor

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33MalaCards
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MalaCards: Amyloid Tumor, also known as amyloid deposition, is related to renal osteodystrophy and alzheimer's disease. An important gene associated with Amyloid Tumor is CALCA (calcitonin-related polypeptide alpha), and among its related pathways is Packaging Of Telomere Ends. The compounds dmsa and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and brain.

Aliases & Classifications for Amyloid Tumor

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

amyloid tumor 8 61
amyloid deposition 61
amyloid neoplasm 8


External Ids:

Disease Ontology8 DOID:6755
SNOMED-CT57 37279009

Related Diseases for Amyloid Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Amyloid Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1renal osteodystrophy30.0CALCA
2alzheimer's disease10.5
3porokeratosis10.5
4brain disease10.5
5cerebral amyloid angiopathy10.5
6transthyretin amyloidosis10.4
7adenoma10.4
8hereditary amyloidosis10.4
9extramedullary plasmacytoma10.3
10prolactinoma10.3
11lattice corneal dystrophy10.3
12gerstmann-straussler-scheinker disease10.3
13amyloidosis, renal10.3
14amyloidosis10.2
15bone fracture10.2
16familial mediterranean fever10.2
17lewy body dementia10.2
18inclusion body myositis10.2
19carpal tunnel syndrome10.2
20down syndrome10.2
21micro syndrome10.2
22familial transthyretin amyloidosis10.2
23amyloidosis cerebral10.2
24lattice corneal dystrophy type 110.2
25dementia familial british10.2
26lattice corneal dystrophy type ii10.2
27amyloidosis, secondary10.2
28lymphoplasmacytoid lymphoma10.2
29senile systemic amyloidosis10.2
30nodular goiter10.0
31vascular dementia10.0
32cystadenoma10.0
33dyskeratosis congenita10.0
34epidermolysis bullosa simplex10.0
35thyroid lymphoma10.0
36vogt-koyanagi-harada disease10.0
37macroglobulinemia10.0
38lipid-rich carcinoma10.0
39proliferative glomerulonephritis10.0
40mesangial proliferative glomerulonephritis10.0
41primary cutaneous amyloidosis10.0
42spondylosis10.0
43pituitary apoplexy10.0
44osteomalacia10.0
45exophthalmos10.0
46spinal stenosis10.0
47vipoma10.0
48microcystic adenoma10.0
49reactive arthritis10.0
50temporal arteritis10.0

Graphical network of the top 20 diseases related to Amyloid Tumor:



Diseases related to amyloid tumor

Clinical Features for Amyloid Tumor

Drugs & Therapeutics for Amyloid Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Amyloid Tumor

Anatomical Context for Amyloid Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Amyloid Tumor:

33
Skin, Tongue, Brain, Lung, Spleen, Small intestine, Colon, Adipocyte, Pancreas, Thyroid, Salivary gland, Breast, Prostate, Monocytes, B cells, Endothelial, Trachea, Pancreatic islet

Animal Models for Amyloid Tumor or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Amyloid Tumor

Sources:
51PubMed
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Articles related to Amyloid Tumor:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
Clinical significance of amyloid precursor protein in patients with testicular germ cell tumor. (23662100)
2013
2
Combination of plasma tumor necrosis factor receptors signaling proteins, beta-amyloid and apolipoprotein E for the detection of Alzheimer's disease. (23500026)
2013
3
Prostate amyloid tumor is a clue leading to the diagnosis of systemic AL amyloidosis. (23826754)
2013
4
Amyloid tumor behaving as localized amyloidosis in a patient with long history of asymptomatic light chain myeloma. (23882901)
2013
5
A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor. (22766792)
2012
6
Levels of amyloid beta-42, interleukin-6 and tumor necrosis factor-alpha in Alzheimer's disease and vascular dementia. (22437436)
2012
7
Tumor necrosis factor-I+ gene polymorphisms in FMF and their association with amyloidosis. (22593232)
2012
8
Mimicking pulmonary multiple metastatic tumors: A case of primary nodular parenchymal pulmonary amyloidosis with review of the literature. (23205137)
2012
9
Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors. (21056685)
2011
10
Carotid body tumor and amyloidosis: an uncommon association. (20228525)
2010
11
Expression of serum amyloid a in human ovarian epithelial tumors: implication for a role in ovarian tumorigenesis. (20713982)
2010
12
Amyloid tumor of the stomach simulating an obstructing gastric carcinoma: case report and review of the literature. (19288419)
2009
13
Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes. (19862700)
2009
14
Solitary amyloid tumor of the tongue base. (20107570)
2009
15
Amyloid tumor of the breast mimicking breast carcinoma. (18364625)
2008
16
Serum amyloid A-induced mRNA expression and release of tumor necrosis factor-alpha (TNF-alpha) in human neutrophils. (14757367)
2004
17
MR spectroscopy in the diagnosis of cerebral amyloid angiopathy presenting as a brain tumor. (15569734)
2004
18
Secondary amyloidosis and gastrointestinal stromal tumors. A case report and discussion of pathogenesis. (12683877)
2003
19
Tumor necrosis factor alpha, its soluble receptor I, and -308 gene promoter polymorphism in patients with rheumatoid arthritis with or without amyloidosis: implications for the pathogenesis of nephropathy and anemia of chronic disease in reactive amyloidosis. (14613268)
2003
20
Anti-tumor necrosis factor alpha therapy in fifteen patients with AA amyloidosis secondary to inflammatory arthritides: a followup report of tolerability and efficacy. (12847696)
2003
21
AA-type amyloid tumor as an unsuspected cause of residual mass in a patient with large B-cell non-Hodgkin's lymphoma. (12002783)
2002
22
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. (11939793)
2002
23
Autosomal-dominant periodic fever with AA amyloidosis: Novel mutation in tumor necrosis factor receptor 1 gene Rapid Communication. (11318938)
2001
24
Effects of the beta-amyloid and carboxyl-terminal fragment of Alzheimer's amyloid precursor protein on the production of the tumor necrosis factor-alpha and matrix metalloproteinase-9 by human monocytic THP-1. (11306564)
2001
25
Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. (10713108)
2000
26
The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis. (10948120)
2000
27
Production of amyloid beta protein precursor as a proteinase inhibitor by human astrocytic tumors. (10652580)
1999
28
Intraabdominal immunoglobulin light chain amyloid tumor encompassing a vascular malformation. (9625589)
1998
29
Primary amyloidoma (amyloid tumor) of soft tissue. (9622729)
1998
30
Localized amyloid tumor of the tongue. A case report and review of the literature. (15678860)
1998
31
A case of renal amyloidosis associated with hepatic adenoma: the pathogenetic role of tumor necrosis factor-alpha. (9069459)
1997
32
Localized primary amyloid tumor associated with osseous metaplasia presenting as bilateral breast masses: cytologic and radiologic features. (8287770)
1993
33
Atypical carcinoid tumor of the lung with amyloid stroma. (1609616)
1992
34
Craniocervical amyloid tumor with destructive spondyloarthropathy and myelocompression as a rare complication of long-term dialysis]. (2108522)
1990
35
Localized primary amyloid tumor of the parotid gland. (3186222)
1988
36
Histoenzymological and ultrastructural study of a bifocal calcifying epithelial odontogenic tumor. Characteristics of epithelial cells and histogenesis of amyloid-like material. (6202055)
1984
37
Primary amyloid tumor of the lacrimal gland: CT findings. (6630639)
1983
38
Crystal-like deposits of amyloid in pancreatic islet cell tumors. (222228)
1979
39
Amyloid tumor of the orbit. (492520)
1979
40
A case of amyloid tumor of the stomach. (631096)
1978
41
Intrasellar amyloid tumor. (4114837)
1972
42
Amyloid tumor of the conjunctiva and eyelid. (5977080)
1966
43
On the origin of amyloid. Study of an amyloid tumor in multiple myeloma. (5923085)
1966
44
Amyloid tumor of the trachea and lung, resembling bronchial asthma. Case report. (13977343)
1962
45
Amyloid tumor of the gasserian ganglion; report of case. (13429403)
1957
46
Amyloid tumor of the bladder. (13307771)
1956
47
Plasma cell myeloma of vertebrae with amyloid tumor, producing paraplegia; report of a case. (13195999)
1954
48
Amyloid tumor formation of skin. (13029905)
1953
49
Amyloid tumor of the stomach; report of a case. (14905406)
1952
50
Amyloid tumor of the larynx requiring laryngofissure. (18112660)
1949

Genetic Variations for Amyloid Tumor

Expression for genes affiliated with Amyloid Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyloid Tumor

Search GEO for disease gene expression data for Amyloid Tumor.

Pathways for genes affiliated with Amyloid Tumor

Sources:
54Reactome
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Pathways related to Amyloid Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1B2M, CALCA

Compounds for genes affiliated with Amyloid Tumor

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
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Compounds related to Amyloid Tumor according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1dmsa459.5B2M, CALCA
2calcium carbonate459.4B2M, CALCA
3pamidronate45 50 1111.4CALCA, B2M
4pmma459.4B2M, CALCA
525-hydroxyvitamin d459.4CALCA, B2M
6nitroglycerin45 1110.4CALCA, B2M
7phosphorus459.4B2M, CALCA
8fluoride459.4B2M, CALCA
9captopril45 29 50 60 1113.4B2M, CALCA
10vincristine45 50 1111.3CALCA, B2M
11thyroxine45 2410.3B2M, CALCA
12calcitriol45 60 11 2412.3B2M, CALCA
13indomethacin45 60 29 1112.2B2M, CALCA
14vitamin d459.2CALCA, B2M
15cyclosporin a45 29 6011.1B2M, CALCA
16creatinine459.1B2M, CALCA
17pge2459.0B2M, CALCA
18lactate458.8B2M, CALCA

GO Terms for genes affiliated with Amyloid Tumor

Sources:
16Gene Ontology
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Molecular functions related to Amyloid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1B2M, CALCA

Products for genes affiliated with Amyloid Tumor

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Sources for Amyloid Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet