MCID: AMY002
MIFTS: 35

Amyloid Tumor malady

Cancer diseases category

Summaries for Amyloid Tumor

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32MalaCards
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MalaCards: Amyloid Tumor, also known as amyloid deposition, is related to renal osteodystrophy and hyperparathyroidism. An important gene associated with Amyloid Tumor is CALCA (calcitonin-related polypeptide alpha), and among its related pathways is Packaging Of Telomere Ends. The compounds dmsa and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and pancreatic islet.

Aliases & Classifications for Amyloid Tumor

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8Disease Ontology, 60UMLS, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

amyloid tumor 8 60
amyloid deposition 60
amyloid neoplasm 8


External Ids:

Disease Ontology8 DOID:6755
SNOMED-CT56 37279009

Related Diseases for Amyloid Tumor

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amyloid Tumor:



Diseases related to amyloid tumor

Clinical Features for Amyloid Tumor

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Drugs & Therapeutics for Amyloid Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Amyloid Tumor

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Anatomical Context for Amyloid Tumor

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32MalaCards
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MalaCards organs/tissues related to Amyloid Tumor:

32
Breast, Lung, Pancreatic islet, Trachea, Tongue, Monocytes, Skin, Thyroid, Prostate, Pancreas, B cells, Endothelial, Adipocyte, Brain, Spleen

Animal Models for Amyloid Tumor or affiliated genes

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Publications for Amyloid Tumor

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50PubMed
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Articles related to Amyloid Tumor:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Prostate amyloid tumor is a clue leading to the diagnosis of systemic AL amyloidosis. (23826754)
2013
2
Amyloid tumor behaving as localized amyloidosis in a patient with long history of asymptomatic light chain myeloma. (23882901)
2013
3
Levels of amyloid beta-42, interleukin-6 and tumor necrosis factor-alpha in Alzheimer's disease and vascular dementia. (22437436)
2012
4
Serum amyloid A, procalcitonin, tumor necrosis factor-alpha, and interleukin-1beta levels in neonatal late-onset sepsis. (19043563)
2008
5
Amyloid tumor of the breast mimicking breast carcinoma. (18364625)
2008
6
Intracranial Aspergillus infection associated with an amyloid tumor and lymphoma. (19412411)
2008
7
Localized Castleman's disease associated with systemic AA amyloidosis. Regression of amyloid deposits after tumor removal. (17001479)
2007
8
Amyloid-beta peptide enhances tumor necrosis factor-alpha-induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes. (16033420)
2005
9
The role of sphingomyelin cycle and tumor necrosis factor alpha in toxic effect of beta-amyloid peptide]. (15071846)
2004
10
Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. (15347683)
2004
11
MR spectroscopy in the diagnosis of cerebral amyloid angiopathy presenting as a brain tumor. (15569734)
2004
12
Amyloid tumor in the anterior mediastinum: report of a case. (15170548)
2004
13
Aspiration cytology diagnosis of a primary amyloid tumor of thoracic vertebra: a case report. (12951685)
2003
14
Cyclic AMP inhibition of tumor necrosis factor alpha production induced by amyloidogenic C-terminal peptide of Alzheimer's amyloid precursor protein in macrophages: involvement of multiple intracellular pathways and cyclic AMP response element binding protein. (12606779)
2003
15
Serum amyloid A1 and tumor necrosis factor-alpha alleles in Turkish familial Mediterranean fever patients with and without amyloidosis. (12762136)
2003
16
Isolated amyloid tumor in the mediastinum: report of a case. (12658387)
2003
17
Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons. (12472889)
2002
18
The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis. (10948120)
2000
19
Localized amyloid tumor of the nasopharynx. (10652414)
2000
20
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. (9774383)
1998
21
Primary amyloidoma (amyloid tumor) of soft tissue. (9622729)
1998
22
Multihormone-producing islet cell tumor of the pancreas associated with somatostatin-immunoreactive amyloid: immunohistochemical and immunoelectron microscopic studies. (9500779)
1998
23
Primary amyloid tumor of the breast: a case report and review of the literature. (9237186)
1997
24
Inhibition of p75 tumor necrosis factor receptor by antisense oligonucleotides increases hypoxic injury and beta-amyloid toxicity in human neuronal cell line. (9013604)
1997
25
Clinical and computed tomographic characteristics of amyloid tumor of the lacrimal gland. (8764792)
1996
26
Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. (7568127)
1995
27
Ga-67 and Tc-99m (V) DMSA imaging in non-Hodgkin's lymphoma with amyloid tumor. (8565385)
1995
28
Recurrent amyloid tumor of the parotid gland. (7536425)
1995
29
Localized primary amyloid tumor associated with osseous metaplasia presenting as bilateral breast masses: cytologic and radiologic features. (8287770)
1993
30
Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes. (2001421)
1991
31
Case report 480: Periosteal amyloid tumor. (3375853)
1988
32
Localized primary amyloid tumor of the parotid gland. (3186222)
1988
33
Amyloid tumor (amyloidoma) of a peripheral nerve. (3021087)
1986
34
Primary amyloid tumor of the breast. Case report and literature review. (3855589)
1985
35
Histoenzymological and ultrastructural study of a bifocal calcifying epithelial odontogenic tumor. Characteristics of epithelial cells and histogenesis of amyloid-like material. (6202055)
1984
36
Amyloid tumor of the breast. (6831938)
1983
37
Immunoperoxidase study of uncommon parathyroid tumors. Report of two cases of nonfunctioning parathyroid carcinoma and one intrathyroid parathyroid tumor-producing amyloid. (6353951)
1983
38
Ultrastructural study of amyloid material in the calcifying epithelial odontogenic tumor. (1175138)
1975
39
Amyloid tumor of the breast. (4683157)
1973
40
Amyloid tumor of the larynx. Case report with electron microscope study. (5030768)
1972
41
Primary amyloid tumor of the trachea. A case report. (5022950)
1972
42
Localized amyloid tumor of the ureter: report of a case. (5556694)
1971
43
Amyloid tumor of the conjunctiva and eyelid. (5977080)
1966
44
LOCALIZED AMYLOIDOSIS (AMYLOID TUMOR) OF THE URETHRA. (14195023)
1964
45
Amyloid tumor of the nose and sinuses. Report of a case. (13994128)
1963
46
Amyloid tumor of the bladder. (13307771)
1956
47
Amyloid tumor formation of skin. (13029905)
1953
48
Amyloid tumor of the stomach; report of a case. (14905406)
1952
49
Primary amyloid tumor of the bladder: report of a case. (14851529)
1951
50
Amyloid tumor of the larynx requiring laryngofissure. (18112660)
1949

Genetic Variations for Amyloid Tumor

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Expression for genes affiliated with Amyloid Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyloid Tumor

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Pathways for genes affiliated with Amyloid Tumor

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53Reactome
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Pathways related to Amyloid Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1B2M, CALCA

Compounds for genes affiliated with Amyloid Tumor

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Amyloid Tumor according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1dmsa449.5CALCA, B2M
2calcium carbonate449.4CALCA, B2M
3pamidronate44 49 1111.4B2M, CALCA
4pmma449.4CALCA, B2M
525-hydroxyvitamin d449.4CALCA, B2M
6nitroglycerin44 1110.4CALCA, B2M
7phosphorus449.4B2M, CALCA
8fluoride449.4CALCA, B2M
9captopril44 28 49 59 1113.4CALCA, B2M
10vincristine44 49 1111.3CALCA, B2M
11thyroxine44 2410.3CALCA, B2M
12calcitriol44 59 11 2412.3B2M, CALCA
13indomethacin44 59 28 1112.2B2M, CALCA
14vitamin d449.2B2M, CALCA
15cyclosporin a44 28 5911.1B2M, CALCA
16creatinine449.1CALCA, B2M
17pge2449.0CALCA, B2M
18lactate448.8CALCA, B2M

GO Terms for genes affiliated with Amyloid Tumor

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16Gene Ontology
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Molecular functions related to Amyloid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1B2M, CALCA

Products for genes affiliated with Amyloid Tumor

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Sources for Amyloid Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet