Amyloidosis malady

MedlinePlus: Amyloidosis occurs when abnormal proteins build up and form deposits. the deposits can collect in organs such as the kidney and heart. this can cause the organs to become stiff and unable to work the way they should. there are three main types of amyloidosis: primary - with no known cause secondary - caused by another disease, including some types of cancer familial - passed down through genes treatment depends on the type of amyloidosis you have.²³

MalaCards: Amyloidosis, also known as amyloid disease, is related to transthyretin amyloidosis and al amyloidosis. An important gene associated with Amyloidosis is TTR (transthyretin), and among its related pathways are Alzheimers Disease Pathway and Disease. The drugs acetylcysteine and colchicine and the compounds leupeptin and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and brain, and related mouse phenotypes are other and endocrine/exocrine gland.

Disease Ontology: An acquired metabolic disease that involves abnormal deposited of amyloid proteins in organs and/or tissues.⁶

Wikipedia: In medicine, amyloidosis refers to a variety of conditions wherein amyloid proteins are abnormally...⁴⁴ more...

Aliases & Descriptions:

amyloidosis 6 7 17 8 32 23 43 amyloid disease 6

Disease types for amyloidosis family:

al amyloidosis	amyloidosis aa

Diseases related to amyloidosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1045)

id	Related Disease	Score	Top Affiliating Genes
1	transthyretin amyloidosis	36.3	RBP4, CLU, ATXN1, TTR, NPPB
2	al amyloidosis	35.8	VWF, SERPINC1, LECT2, B2M, CD79A, CD14
3	hereditary amyloidosis	35.6	GSN, APOA1, TTR
4	hereditary cerebral hemorrhage with amyloidosis	34.8	SERPINF2, IL6, APP, HSPB6, HSPB8, CTSD
5	familial transthyretin amyloidosis	34.6	GSN, APOA1, TTR, DBH
6	primary cutaneous amyloidosis	34.4	RET, BCL2, YARS, IL31, IL31RA, FAS
7	familial mediterranean fever	34.3	MEFV, TNF, TNFRSF1A, NLRP3
8	amyloidosis, secondary	33.4	LPA, LCAT, SAA1, SAA2, SAA4, B2M
9	alzheimer's disease	33.3	CLU, ITM2B, APOE, APP, MAPT, IDE
10	lattice corneal dystrophy type ii	33.1	GSN, APOE, TTR
11	arthritis	33.0	MMP3, IL1B, IL6, TNF, TNFRSF1A, CTSB
12	cerebral hemorrhage	32.7	SERPINF2, SERPINA3, INS, IL1B, IL1RN, IL6
13	amyloidosis, renal	32.5	SAA4, B2M, APOA1, FAR2, FAR1, LYZ
14	rheumatoid arthritis	31.8	CD40, MICA, IL1B, IL1RN, HLA-DRB1, TNF
15	amyloidosis corneal	31.4	GSN, LTF, TGFBI, TACSTD2
16	muckle-wells syndrome	30.6	MEFV, IL1B, IL1R1, IL1RAPL2, IL3, TNFRSF1A
17	corneal dystrophy	30.2	CLU, LCAT, GSN, APOE, KRT17, LTF
18	periodic fever	30.0	MVK, SAA1, MEFV, IL1B, IL1R1, IL1RAPL2
19	lattice corneal dystrophy	29.3	GSN, TGFB1, TGFBI, TGIF1, TACSTD2
20	light chain deposition disease	28.9	CD14, CD68, IGKC
21	cerebral amyloid angiopathy	28.6	LRP1, SERPINA3, ITM2B, MME, MMP9, GSN
22	multiple myeloma	28.3	VTN, FGFR3, IL6, CCND1
23	retinol binding protein	28.3	RBP4, LPA, B2M, INS, APOA1, APP
24	carpal tunnel syndrome	28.3	B2M, INS, MFGE8, IL1B, IL6, APCS
25	hepatitis	28.3	RBP4, FAS, IFNA2, ALB, HLA-A, HLA-DRB1
26	creutzfeldt-jakob syndrome	28.3	SERPINA3, APOE, APP, MAPT, SNCA, CRYAB
27	hemarthrosis	27.8	VWF, F9, F8, F10
28	extramedullary plasmacytoma	27.8	BCL2, B2M, IL6, CCND1, IGKC
29	thromboembolism	27.7	LRP1, VWF, SERPINC1, SERPINF2, SERPINA3, FGA
30	castleman's disease	27.6	B2M, IL6, IGH@, F8, ALB, TP53
31	paraproteinemia	27.5	CD79A, IL6, MAG
32	wells syndrome	27.5	MEFV, IL1B, IL1R1, IL1RAPL2, IL3, TNFRSF1A
33	familial cold autoinflammatory syndrome	27.4	MEFV, IL1B, IL1R1, TNFRSF1A, NLRP3
34	intestinal pseudo-obstruction	27.4	RET, B2M, FAS, ALB, TNF
35	peripheral neuropathy	27.4	YARS, ATXN1, CD40LG, INS, GSN, IL3
36	protein-losing enteropathy	27.4	CD79A, ALB, TF, NPPB
37	spondylarthropathy	27.4	B2M, IL1RAPL2, TNF, CRP, TLR4
38	rosai-dorfman disease	27.3	SERPINA3, CTSD, CRP, TF
39	polyneuropathy	27.3	RBP4, CLU, B2M, CD79A, CD40LG, MMP9
40	plasmacytoma	27.3	PCSK5, BCL2, B2M, CD79A, CD40, IRF4
41	proteinuria	27.2	VWF, VTN, RBP4, SERPINC1, LPA, CLU
42	hearing loss	27.0	SERPINC1, GSN, FGFR3, APOE, IFNA2, F5
43	macroglobulinemia	27.0	LPL, BCL2, B2M, CD79A, CD40LG, CD40
44	cutis laxa	26.9	CD79A, CD40LG, FOS, GSN, FBN1, ABCC6
45	autonomic neuropathy	26.8	INS, ALB, AGER, TTR, DBH, NPPA
46	invasive aspergillosis	26.8	CD79A, MBL2, IFNG, TLR4, CSF3
47	hyper-igd syndrome	26.7	MVK, SAA1, IL1RN, TNF, TNFRSF1A, CRP
48	basal cell carcinoma	26.4	BCL2, MME, MMP3, TP53, KRT17, KRT10
49	chronic kidney failure	26.4	LPL, B2M, CD79A, INS, ALB, LTF
50	behcet's disease	26.4	MEFV, MBL2, IFNA2, F5, HSPG2, HLA-A

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetylcysteine, colchcine, colchicine

MalaCards organs/tissues related to amyloidosis:

²²

MGI Mouse Phenotypes related to amyloidosis:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	other phenotype	MP:0005395	10.3	APCS, APOA2, APOA4, APOE, APP, MAPT
2	endocrine/exocrine gland phenotype	MP:0005379	10.1	SLC26A3, DBH, PSEN2, PSEN1, TLR2, CTSK
3	respiratory system phenotype	MP:0005388	10.0	HSPB8, TNNI3, AGRN, PSEN1, PSEN2, C5
4	hematopoietic system phenotype	MP:0005397	9.8	PYCARD, CTSK, TGFBI, OSMR, CSF2, CSF3
5	craniofacial phenotype	MP:0005382	9.7	KRT10, TGIF1, PSEN1, PSEN2, CSF2, WHSC1
6	renal/urinary system phenotype	MP:0005367	9.7	RET, PCSK5, ZMPSTE24, CLU, BCL2, LCAT
7	limbs/digits/tail phenotype	MP:0005371	9.5	KRT5, KRT10, AGRN, TLR4, TGIF1, PSEN1
8	normal phenotype	MP:0002873	8.9	AGRN, AGER, NLRP3, CTSB, DMPK, PYCARD
9	no phenotypic analysis	MP:0003012	8.5	IGHG1, IGKC, TP53, SNCA, AGER, SYP
10	digestive/alimentary phenotype	MP:0005381	8.4	RET, PYCARD, HSPG2, IFNG, APOE, APOA4
11	integument phenotype	MP:0010771	8.3	ZMPSTE24, TP53, TNFRSF1A, CTSB, SNCA, NLRP3
12	behavior/neurological phenotype	MP:0005386	8.1	AGER, ACTG1, KRT5, NFKB1, CRYAB, SNCA
13	reproductive system phenotype	MP:0005389	8.0	CCND1, IFNG, F8, F10, TNF, TNFRSF1A
14	liver/biliary system phenotype	MP:0005370	7.9	TP53, HSPG2, F9, IFNG, NLRP3, TLR2
15	nervous system phenotype	MP:0003631	7.9	SNCA, TLR2, TLR4, TGFB1, TGIF1, SYP
16	immune system phenotype	MP:0005387	7.8	FOS, IRF4, GSN, FGFR3, MFGE8, MEFV
17	adipose tissue phenotype	MP:0005375	7.5	TP53, TNF, TNFRSF1A, CRYAB, TLR2, TLR4
18	tumorigenesis	MP:0002006	7.5	IL1B, IL3, IL6, FAS, MAPT, MAPKAPK5
19	skeleton phenotype	MP:0005390	7.4	TP53, TNFRSF1A, CTSK, SNCA, CRYAB, NFKB1
20	mortality/aging	MP:0010768	7.2	SERPINC1, LPL, ZMPSTE24, PARK2, LECT2, BACE1
21	muscle phenotype	MP:0005369	7.1	ATXN1, AGER, AGRN, GFAP, TLR2, TGFB1
22	growth/size phenotype	MP:0005378	7.0	CDSN, FOS, INS, FGFR3, MEFV, IL6
23	vision/eye phenotype	MP:0005391	6.6	ABCC6, CRYAB, CTSD, TNFRSF1A, TNF, TP53
24	cellular phenotype	MP:0005384	6.1	FPR1, CCND1, IGHG1, IGKC, IFNG, HSPG2
25	homeostasis/metabolism phenotype	MP:0005376	5.0	DCN, PSEN1, PSEN2, DBH, PRNP, SOD1
26	cardiovascular system phenotype	MP:0005385	4.9	CLU, BCL2, LCAT, B2M, FURIN, CDSN

Articles related to amyloidosis:

(show top 50)    (show all 661)

id	Title	Authors	Year	Affiliating Genes
1	Recurrence of vitreous amyloidosis and need of surgic al reintervention in Portuguese patients with familial amyloidosis ATTR V30M. (21358362)	BeirALo N.M.... Torres P.	2011	TTR
2	Prion protein amyloidosis with divergent phenotype as sociated with two novel nonsense mutations in PRNP. (19911184)	Jansen C.... Rozemuller A.J.	2010	PRNP
3	New insight into mechanisms of pruritus from molecula r studies on familial primary localized cutaneous amyloidosis. (19663869)	Tanaka A.... McGrath J.A.	2009	OSMR, IL31
4	Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immu noglobulin light chain amyloidosis. (19781421)	Connors L.H.... Skinner M.	2009	TTR
5	Vitreous amyloidosis in two sisters as the indication of transthyretin-related familial form of systemic amyloidosis among liver tra nsplantation candidates. (19857683)	Niemczyk R.... OA8dakowska-Jedynak U.	2009	TTR
6	Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. (19036982)	Dodson S.E.... Lah J.J.	2008	APP, SORL1
7	Serum uric acid: novel prognostic factor in primary systemic amyloidosis. (18315995)	Kumar S.... Gertz M.A.	2008	NPPB
8	Renal and gastrointestinal amyloidosis in an HIV-infected injection drug user. (17524203)	Newey C.... Miller R.F.	2007	SAA4
9	TGFBI (BIGH3) gene mutations in Hungary--report of the novel F547S mutation associated with polymorphic corneal amyloidosis. (17982422)	Takacs L.... Berta A.	2007	TGFBI
10	Cerebral vascular accumulation of Dutch-type Abeta42, but not wild-type Abeta42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type. (17628026)	Nishitsuji K.... Mori H.	2007	APP
11	Biochemical characterization of vitreous and cardiac amyloid in Ile84Ser transthyretin amyloidosis. (17062384)	Liepnieks J.J.... Benson M.D.	2006	TTR
12	A complex case of renal amyloidosis with a rare co-occurrence of 2 mutations in separate hereditary periodic fever syndrome-related genes. (17048217)	Cigni A.... Satta A.E.	2006	TNF
13	Amyloidosis. (16615878)	Comenzo R.L.	2006	TTR
14	Aging and transthyretin-related amyloidosis: pathologic examinations in pulmonary amyloidosis. (16690497)	Ueda M.... Uchino M.	2006	TTR
15	Underdiagnosed amyloidosis: amyloidosis of lysozyme variant. (15745733)	Granel B.... Droz D.	2005	LYZ
16	Amyloidosis of pancreatic islets in primary amyloidosis (AL type). (15826250)	Tomita T.	2005	IAPP
17	Heart transplantation in a 68-year-old patient with senile systemic amyloidosis. (15816901)	Fuchs U.... Koerfer R.	2005	TTR
18	Portuguese-type amyloidosis (transthyretin amyloidosis, ATTR V30M). (12832749)	Lobato L.	2003	TTR
19	Efficacy of cyclophosphamide combined with prednisolone in patients with AA amyloidosis secondary to rheumatoid arthritis. (14677008)	Nakamura T.... Baba S.	2003	ALB, CRP
20	Tumor necrosis factor alpha, its soluble receptor I, and -308 gene promoter polymorphism in patients with rheumatoid arthritis with or without amyloidosis: implications for the pathogenesis of nephropathy and anemia of chronic disease in reactive amyloidosis. (14613268)	Maury C.P.... Hurme M.	2003	TNF
21	APOA1 related amyloidosis: a case report and literature review. (14636880)	Joy T.... Hegele R.A.	2003	APOA1
22	Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. (12050338)	Lachmann H.J.... Hawkins P.N.	2002	APOA1, TTR, FGA
23	Aged onset of amyloidosis caused by transthyretin gene mutations (11523162)	Nakazato M.... Matsukura S.	2001	TTR
24	The disintegration of a molecule: the role of gelsolin in FAF, familial amyloidosis (Finnish type). (11226199)	Robinson R.C.... Burtnick L.D.	2001	GSN
25	Danish type gelsolin related amyloidosis: 654G-T mutation is associated with a disease pathogenetically and clinically similar to that caused by the 654G-A mutation (familial amyloidosis of the Finnish type). (10767822)	Maury C.P.... Nurmiaho-Lassila E.L.	2000	GSN
26	Late onset lattice corneal dystrophy with systemic familial amyloidosis, amyloidosis V, in an English family. (10729296)	Stewart H.S.... Black G.C.	2000	GSN
27	Primary amyloidosis presenting as a nasopharyngeal mass. (10392240)	Lim J.S.... Jacobs J.B.	1999	IGKC
28	Impact of age and amyloidosis on thiol conjugation of transthyretin in hereditary transthyretin amyloidosis. (10524283)	Suhr O.B.... Ando Y.	1999	TTR
29	Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy: implications for amyloid fibrillogenesis. (9701270)	Stangou A.J.... Williams R.	1998	TTR
30	Instability of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. (9565605)	Wei L.... Levy E.	1998	CST3
31	Visceral organ involvement and extracellular matrix changes in beta 2-microglobulin amyloidosis--a comparative study with systemic AA and AL amyloidosis. (9230913)	Ohashi K.... Hara M.	1997	B2M
32	RET mutation screening in familial cutaneous lichen amyloidosis and in skin amyloidosis associated with multiple endocrine neoplasia. (8757765)	Hofstra R.M.... Buys C.H.	1996	RET
33	Diagnostic aspects of beta 2-microglobulin amyloidosis. (8804016)	Schaeffer J.... Koch K.M.	1996	B2M
34	Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP. (8570627)	Ghetti B.... Tagliavini F.	1996	PRNP
35	Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis. (7753801)	Tennent G.A.... Pepys M.B.	1995	APP
36	Expression of inflammatory cytokines and adhesion molecules in haemodialysis-associated amyloidosis. (8643171)	Inoue H.... Miyasaka N.	1995	B2M
37	Asp187Asn mutation of gelsolin in an American kindred with familial amyloidosis, Finnish type (FAP IV). (7868127)	Steiner R.D.... Benson M.D.	1995	GSN
38	Involvement of beta 2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleukin-1. (8113390)	Miyata T.... Seo H.	1994	B2M
39	beta 2-Microglobulin amyloidosis: illustrative cases. (8191619)	Picken M.M.... Shen S.	1994	B2M
40	Intestinal pseudo-obstruction in patients with amyloidosis: clinicopathologic differences between chemical types of amyloid protein. (8244111)	Tada S.... Fujishima M.	1993	B2M
41	Serum amyloid P component: a predictor of clinical beta 2-microglobulin amyloidosis. (1585929)	Spiegel D.M.... Sprague S.M.	1992	B2M
42	Gelsolin gene mutation--at codon 187--in familial amyloidosis, Finnish: DNA-diagnostic assay. (1311149)	Haltia M.... Frangione B.	1992	GSN
43	Inflammatory cell infiltration around beta 2-microglobulin amyloid deposition: histologic comparison of beta 2-microglobulin amyloidosis with AA or AL amyloidosis (1479708)	Kawai R.... Mimura N.	1992	B2M
44	Amyloid and amyloidosis. (1543671)	Cohen A.S.... Jones L.A.	1992	B2M
45	Pulmonary vascular amyloidosis in aged dogs. A new form of spontaneously occurring amyloidosis derived from apolipoprotein AI. (1443041)	Johnson K.H.... Westermark P.	1992	APOA1
46	Gelsolin-related amyloidosis. Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin. (1849145)	Maury C.P.	1991	GSN
47	Imaging of haemodialysis-associated amyloidosis with 123I-serum amyloid P component. (1677697)	Nelson S.R.... Pepys M.B.	1991	B2M
48	Purification and partial characterization of a new 85 KDa amyloidosis-related protein in chronic hemodialysis. (2039487)	Brancaccio D.... Gusmano R.	1991	B2M
49	A homozygous transthyretin variant associated with senile systemic amyloidosis: evidence for a late-onset disease of genetic etiology. (2349941)	Jacobson D.R.... Buxbaum J.N.	1990	TTR
50	Beta 2-microglobulin amyloidosis in a patient treated exclusively by continuous ambulatory peritoneal dialysis. (2403753)	Jadoul M.... van Ypersele de Strihou C.	1990	B2M

Genes related to amyloidosis according to GeneCards:

(show top 50)    (show all 182)

id	Symbol	Description	Score	GeneCards Section Context
1	TTR	transthyretin	11.1	Summaries, Publications, Aliases & Descriptions, Orthologs
2	GSN	gelsolin	11.1	Publications, Aliases & Descriptions, Summaries
3	LYZ	lysozyme	11.1	Aliases & Descriptions, Summaries, Publications
4	APOA1	apolipoprotein A-I	11.1	Summaries, Publications
5	APP	amyloid beta (A4) precursor protein	11.1	Publications, Orthologs, Summaries
6	FGA	fibrinogen alpha chain	11.1	Publications, Summaries
7	OSMR	oncostatin M receptor	11.1	Publications, Summaries
8	FPR3	formyl peptide receptor 3	11.0	Summaries
9	FPR2	formyl peptide receptor 2	11.0	Summaries
10	FPR1	formyl peptide receptor 1	11.0	Summaries
11	B2M	beta-2-microglobulin	11.0	Publications
12	SAA4	serum amyloid A4, constitutive	11.0	Publications
13	SAA1	serum amyloid A1	11.0	Publications, Functions
14	APOA2	apolipoprotein A-II	11.0	Publications
15	CST3	cystatin C	11.0	Publications
16	APOE	apolipoprotein E	11.0	Publications
17	SAA2	serum amyloid A2	11.0	Publications
18	MEFV	Mediterranean fever	11.0	Publications
19	RET	ret proto-oncogene	11.0	Publications
20	NPPB	natriuretic peptide B	11.0	Publications
21	IL31RA	interleukin 31 receptor A	11.0	Publications
22	APCS	amyloid P component, serum	11.0	Publications
23	TACSTD2	tumor-associated calcium signal transducer 2	11.0
24	TGFBI	transforming growth factor, beta-induced, 68kDa	11.0	Publications
25	FURIN	furin (paired basic amino acid cleaving enzyme)	11.0	Publications
26	KRT10	keratin 10	11.0	Publications
27	RBP4	retinol binding protein 4, plasma	11.0	Publications
28	F9	coagulation factor IX	11.0	Publications
29	CLU	clusterin	11.0	Publications
30	LTF	lactotransferrin	11.0	Publications
31	F10	coagulation factor X	11.0	Publications
32	RPS27A	ribosomal protein S27a	11.0	Publications
33	PSEN1	presenilin 1	11.0	Publications
34	CTSD	cathepsin D	11.0	Publications
35	CTSB	cathepsin B	11.0	Publications
36	LPA	lipoprotein, Lp(a)	11.0
37	ATXN1	ataxin 1	11.0	Publications
38	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
39	IL31	interleukin 31	11.0	Publications
40	IGKC	immunoglobulin kappa constant	11.0	Publications
41	HSPB6	heat shock protein, alpha-crystallin-related, B6	11.0	Publications
42	LECT2	leukocyte cell-derived chemotaxin 2	11.0	Publications
43	MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)	11.0	Publications
44	CD68	CD68 molecule	11.0	Publications
45	EARS2	glutamyl-tRNA synthetase 2, mitochondrial (putative)	11.0
46	FAR1	fatty acyl CoA reductase 1	11.0
47	HSPB8	heat shock 22kDa protein 8	11.0	Publications
48	APLP1	amyloid beta (A4) precursor-like protein 1	11.0	Orthologs
49	IAPP	islet amyloid polypeptide	11.0	Publications
50	SNCG	synuclein, gamma (breast cancer-specific protein 1)	11.0

Pathways related to amyloidosis according to GeneDecks:

(show top 50)    (show all 101)

id	Pathway	Score	Top Affiliating Genes
1	Alzheimers Disease Pathway36	10.9	ADAM10, PSEN1, MAPT, APP, APOE, PSEN2
2	Disease38	10.8	TGFBI, ITM2B, LYZ, NPPA, CST3, TTR
3	Neuroscience3	10.8	PSEN1, SYP, GFAP, SNCA, MAG, MAPT
4	Alzheimers disease20	10.7	PSEN2, ADAM10, PSEN1, SNCA, TNFRSF1A, APBB1
5	Bacterial infections in CF airways41	10.7	CTSB, TLR2, IL1R1
6	Immune response Classic complement pathway10	10.7	IGKC, CRP, C5, CLU, IGH@, IGHG1
7	Immune response_Classical complement pathway41	10.6	IGLV@, CLU, IGH@, IGHG1, IGKC, IGKV@
8	Graft-versus-host disease20	10.6	HLA-B, HLA-A
9	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	TNFRSF1A, CSF2, BCL2
10	Immune response_CD16 signaling in NK cells41	10.5	ACTG1, IGH@, IGLV@, IGHG1, IGKV@, IGKC
11	Blood Coagulation Signaling Pathways37	10.4	VWF, F10, A2M, F12, F5, F8
12	Complement and coagulation cascades20	10.3	SERPINF2, SERPINC1, VWF, FGA, F9, F8
13	Immune response_Bacterial infections in normal airways41	10.1	CD14, IFNG, IL1R1, IL1B
14	Selected targets of HNF110	10.0	APOA2, INS, APOA1, CRP, ALB, IAPP
15	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.9	FOS, CALR, BGLAP, IFNG, IL1B, TNF
16	Immune System38	9.9	SAA1, HGF, CSF2, CD79A, CD40, MEFV
17	Immune response CD16 signaling in NK cells10	9.9	FOS, IGKC, IGH@, IGLV@, IGHG1, IGKV@
18	Pertussis20	9.9	PYCARD, NLRP3, NFKB1, TLR4, C5, IL6
19	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.8	IL1B, TNF, CALR, IFNG, APOE, BGLAP
20	Inflammasome Activation Pathways37	9.7	FOS, TLR2, TLR4, NLRP3, PYCARD, NFKB1
21	NF-kappaB Signaling3	9.7	TLR4, TNFRSF1A, TLR2, TNF, IRF4, AGER
22	Hematopoietic cell lineage20	9.7	MME, CD14, IL1B, CSF2, TNF, HLA-DRB1
23	Toll-like receptor signaling pathway20	9.6	CD40, TNF, NFKB1, FOS, CTSK, IFNA2
24	MIF Mediated Glucocorticoid Regulation36	9.6	CD14, CSF2, OSM, TLR4, NFKB1, TNF
25	Allograft rejection20	9.6	CD40LG, HLA-DRB1, HLA-B, HLA-A, IFNG, FAS
26	IL-10 Pathway36	9.5	CCND1, IL1B, CD14, TLR4, IL6, TNF
27	PEDF Induced Signaling36	9.5	BCL2, FOS, IL1B, IL3, IL6, TNF
28	Cytokine production by Th17 cells in CF (Mouse model)41	9.5	IL6, CD14, TGFB1, CSF3, TLR4, NFKB1
29	Amoebiasis20	9.5	IL1B, TGFB1, TLR2, TLR4, IL1R1, CD14
30	HMGB1 Pathway36	9.4	IL1B, FOS, IL1R1, TNF, TNFRSF1A, NFKB1
31	Tec Kinases Signaling36	9.2	NFKB1, BCL2, FOS, FGFR3, IL3, IL6
32	Influenza A20	9.0	TNFRSF1A, PYCARD, NLRP3, NFKB1, ACTG1, TNF
33	Chagas disease (American trypanosomiasis)20	9.0	IL1B, CALR, TGFB1, TLR2, NFKB1, TNFRSF1A
34	Apoptosis20	8.9	IL1B, IL1R1, IL3, FAS, TP53, TNF
35	Malaria20	8.8	HGF, CSF3, CD40, TGFB1, TLR4, TLR2
36	MIF Regulation of Innate Immune Cells36	8.8	CSF2, CSF3, OSM, TLR4, NFKB1, TNF
37	Type I diabetes mellitus20	8.8	HLA-B, INS, IL1B, FAS, IFNG, TNF
38	Cytokine-cytokine receptor interaction20	8.8	IL3, IL1R1, FAS, IL1B, CD40, CD40LG
39	Immune response MIF in innate immunity response10	8.7	CD14, TLR4, NFKB1, TP53, IFNG, IL6
40	Immune response_MIF in innate immunity response41	8.7	NFKB1, TNF, TP53, IFNG, IL6, CD14
41	NF-KappaB (p50-p65) Pathway36	8.6	TNFRSF1A, FGFR3, IL1R1, IL3, IL6, NFKB1
42	Rheumatoid arthritis20	8.6	IL6, MMP3, TGFB1, TLR4, TLR2, CTSK
43	Toxoplasmosis20	8.5	TGFB1, BCL2, TLR4, TLR2, NFKB1, TNFRSF1A
44	Antioxidant Action of Vitamin-C36	8.5	CSF3, OSMR, FOS, CSF2, IL1B, IL1R1
45	NF-KappaB Family Pathway36	8.5	IL1B, IL6, IL3, TNFRSF1A, NFKB1, TLR2
46	Molecular Mechanisms of Cancer36	8.5	PSEN1, PSEN2, CCND1, OSMR, HGF, BCL2
47	Tuberculosis20	8.5	CD14, TLR2, TNF, NFKB1, CTSD, TNFRSF1A
48	Leishmaniasis20	8.4	TNF, HLA-DRB1, FOS, TLR4, IL1B, TGFB1
49	p38 Signaling36	7.6	TNFRSF1A, NFKB1, OSMR, IL1B, FGFR3, MAPKAPK5
50	Colorectal Cancer Metastasis36	7.4	TLR4, TP53, TNF, TLR2, NFKB1, IFNG

Compounds related to amyloidosis according to GeneDecks:

(show top 50)    (show all 459)

id	Compound	Score	Top Affiliating Genes
1	leupeptin32	11.1	VWF, FURIN, MME, APP, IDE, F10
2	sialic acid32	10.6	RBP4, SERPINF2, SERPINA3, LPA, CLU, BACE1
3	phosphatidylserine32 9 9	12.6	VWF, LPL, BCL2, CD79A, CD14, GSN
4	aprotinin32 9 9	12.5	LRP1, VWF, SERPINC1, SERPINF2, FURIN, MMP9
5	valine32	10.5	RET, RBP4, SERPINA3, LPL, SAA1, B2M
6	ivig32	10.4	VWF, IL1RAPL2, IL3, MAG, F9, F8
7	threonine32	10.4	RET, PARK2, FGFR3, IL1RAPL2, ANPEP, MAPT
8	hyaluronic acid32 18	11.2	VTN, MYOM2, B2M, MMP3, FBN1, HMMR
9	calcitriol32 42 9 18 9	14.2	CLU, BGLAP, B2M, CD14, FOS, IL3
10	glucose32	10.2	PARK2, MME, GSN, IFNA2, IDE, CALR
11	kininogen32	10.2	VWF, VTN, SERPINC1, SERPINF2, CLU, APOA1
12	dopamine32 9 18 9	13.1	RET, RBP4, SERPINA3, CLU, PARK2, CD79A
13	chloroquine32 34 9 9	13.1	VTN, SERPINC1, BACE1, B2M, CD79A, IL1R1
14	polyethylene glycol32	10.0	VTN, SERPINC1, APOA1, APOE, ANPEP, IFNA2
15	heparan sulfate32 18	10.9	LRP1, RET, VTN, SERPINC1, SERPINF2, LPL
16	rituximab32 34 9 9	12.8	BCL2, CD79A, CD40LG, CD40, IL1R1, MAG
17	fmlp32	9.8	SERPINA3, CD14, FPR1, FPR2, FPR3, GSN
18	uric acid32 18	10.7	RBP4, LPA, SAA4, B2M, INS, IL1R1
19	folate32	9.6	VWF, RBP4, SERPINC1, SERPINA3, LPA, CLU
20	adenylate32	9.6	VWF, RBP4, SERPINC1, LPL, FURIN, CD40LG
21	formaldehyde32 18	10.5	VWF, B2M, CD79A, CD40LG, MMP9, IL1RN
22	oxygen32 18	10.5	RBP4, SERPINF2, SERPINA3, CLU, PARK2, BCL2
23	histamine32 18	10.4	VWF, BGLAP, CD79A, CD14, CD40LG, CD40
24	heparin32 9 18 9	12.3	LRP1, VWF, VTN, SERPINF2, SERPINA3, LPA
25	copper32 18	10.3	RBP4, LPA, BACE1, FURIN, APLP1, APLP2
26	doxorubicin32 34 9 9	12.3	CLU, B2M, CD40LG, CD40, FGFR3, FAS
27	estrogen32	9.2	VWF, RBP4, SERPINC1, SERPINA3, LPA, LPL
28	sb 20358032 42	10.2	BGLAP, BCL2, MMP3, MMP9, FPR1, FOS
29	herbimycin a32 42	10.0	RET, VTN, CD14, CD40LG, CD40, MMP9
30	prostacyclin32	8.9	VWF, VTN, SERPINC1, MME, FGA, IL1B
31	glutamine32	8.9	VWF, VTN, SERPINF2, LPL, PARK2, LECT2
32	n acetylcysteine32	8.8	VWF, SERPINC1, CLU, CD79A, CD40, MMP3
33	genistein32 9 18 9	11.8	RET, LPL, BCL2, B2M, CD40LG, CD40
34	infliximab32 9 9	10.8	BGLAP, MMP3, IL1B, IL1R1, IL1RAPL2, IL1RN
35	tamoxifen32 34 9 9	11.8	VTN, SERPINC1, LPL, CLU, BGLAP, BCL2
36	neopterin32	8.7	CHIT1, SAA4, B2M, CD79A, CD14, CD40LG
37	prednisolone32 9 9	10.6	VWF, BGLAP, CD79A, CD14, CD40, MMP3
38	calcium32 9 18 9	11.5	LRP1, VWF, VTN, RBP4, SERPINF2, SERPINA3
39	cyclosporin a32 42	9.5	VWF, LPL, BGLAP, B2M, CD14, CD40
40	thalidomide32 42 9 9	11.4	VTN, B2M, CD40LG, FGFR3, IL1B, IL6
41	cholesterol32 9 18 9	11.3	LRP1, VWF, VTN, RBP4, SERPINF2, SERPINA3
42	paraffin32	8.3	RET, VWF, SERPINA3, CLU, BGLAP, BCL2
43	nitric oxide32 9 18 9	11.2	LPA, PARK2, CD40, MME, FPR1, IL1B
44	cisplatin32 34 9 9	11.2	VTN, CLU, BGLAP, BCL2, B2M, CD40LG
45	butyrate32	8.1	RET, CLU, BCL2, LCAT, B2M, CD14
46	tacrolimus32 34 9 9	10.6	VTN, CD79A, CD40, INS, IL3, APOA1
47	actinomycin d32	7.5	LPA, CLU, PAPPA, BCL2, CD40LG, CD40
48	lipid32	7.3	LRP1, RET, VTN, RBP4, SERPINF2, SERPINA3
49	dexamethasone32 42 34 9 9	10.9	LRP1, VWF, VTN, RBP4, SERPINC1, SERPINA3
50	retinoic acid32 42 18	8.7	LRP1, RET, VWF, VTN, RBP4, SERPINA3

Cellular components related to amyloidosis according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle	GO:034364	11.0	APOE, APOA4, APOA2, APOA1, SAA4, SAA2
2	very-low-density lipoprotein particle	GO:034361	10.7	APOE, APOA4, APOA2, APOA1, LPL
3	chylomicron	GO:042627	10.3	APOE, APOA4, APOA2, LPL
4	lysosomal lumen	GO:043202	10.2	GBA, DCN, AGRN, CTSD, HPSE, HSPG2
5	extracellular matrix	GO:031012	10.1	SOD1, DCN, TGFBI, AGRN, CTSD, HSPG2
6	cell surface	GO:009986	9.7	HMMR, TNF, TNFRSF1A, CRYAB, TLR2, TGFB1
7	platelet alpha granule lumen	GO:031093	9.4	HGF, TGFB1, A2M, ALB, F5, F8
8	external side of plasma membrane	GO:009897	9.3	IFNG, CALR, HLA-DRB1, TNF, CTSB, TLR2
9	secretory granule	GO:030141	9.3	DBH, TF, LTF, APOA1, IL1B, INS
10	Golgi lumen	GO:005796	9.3	DCN, TGFB1, AGRN, HSPG2, F10, F9
11	integral to plasma membrane	GO:005887	9.1	TNFRSF1A, TNF, HLA-DRB1, HLA-B, AGER, TLR2
12	protein complex	GO:043234	9.0	PSEN2, SYP, TNFRSF1A, TP53, ALB, APCS
13	plasma membrane	GO:005886	8.3	HMMR, HLA-A, HLA-B, HLA-DRB1, TNF, TNFRSF1A
14	cytosol	GO:005829	6.9	RPS27A, CRYAB, SNCA, SUOX, DMPK, PYCARD
15	extracellular space	GO:005615	6.2	CD14, CD40LG, ITM2B, MMP3, MMP9, MICA
16	extracellular region	GO:005576	6.2	LYZ, C5, HAMP, HGF, EPO, VWF

Biological processes related to amyloidosis according to GeneDecks:

(show top 50)    (show all 62)

id	Name	GO ID	Score	Top Affiliating Genes
1	reverse cholesterol transport	GO:043691	11.1	APOE, CLU, LCAT, APOA1, APOA2, APOA4
2	high-density lipoprotein particle remodeling	GO:034375	11.0	APOE, APOA4, APOA2, APOA1, LCAT
3	cholesterol metabolic process	GO:008203	11.0	SORL1, MBTPS2, APOE, APOA4, APOA2, APOA1
4	positive regulation of cholesterol esterification	GO:010873	10.9	APOE, APOA4, APOA2, APOA1
5	very-low-density lipoprotein particle remodeling	GO:034372	10.8	APOE, APOA4, LCAT, LPL
6	lipoprotein metabolic process	GO:042157	10.8	HSPG2, ALB, APOE, APOA4, APOA2, APOA1
7	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	10.7	NLRP3, RPS27A, PYCARD, APP, MEFV, BCL2
8	phospholipid efflux	GO:033700	10.7	APOE, APOA4, APOA2, APOA1
9	complement activation, classical pathway	GO:006958	10.7	C5, CRP, LOC440786, IGKC, IGLV7-43, IGHG1
10	complement activation	GO:006956	10.7	C5, LOC440786, IGKC, IGLV7-43, IGHG1, MBL2
11	blood coagulation, intrinsic pathway	GO:007597	10.6	A2M, F12, F10, F8, F9, VWF
12	lipid metabolic process	GO:006629	10.5	HSPG2, ALB, APOE, APOA4, APOA2, APOA1
13	regulation of immune response	GO:050776	10.5	HLA-B, HLA-A, ICAM3, LOC440786, IGKC, IGLV7-43
14	negative regulation of inflammatory response	GO:050728	10.5	GBA, NLRP3, TNFRSF1A, APOE, APOA1, MEFV
15	B cell proliferation	GO:042100	10.5	CD40, CD40LG, CD79A, BCL2
16	response to copper ion	GO:046688	10.3	LCAT, NFKB1, DBH, PRNP, SOD1, BCL2
17	response to estrogen stimulus	GO:043627	10.2	EPO, CCND1, FAS, APOA2, MFGE8, BCL2
18	positive regulation of tyrosine phosphorylation of Stat1 protein	GO:042511	10.1	TNFRSF1A, IFNG, FGFR3, CD40
19	response to glucocorticoid stimulus	GO:051384	10.1	TNF, FAS, APOA2, IL6, IL1RN, IL1B
20	positive regulation of membrane protein ectodomain proteolysis	GO:051044	10.1	TNF, IFNG, APOE, IL1B, FURIN
21	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.0	OSM, TGFB1, SNCA, TNF, IL6, BCL2
22	proteolysis	GO:006508	10.0	F9, IDE, F10, F12, PYCARD, CTSD
23	acute-phase response	GO:006953	10.0	IL6, APCS, MBL2, F8, CRP, IL1RN
24	negative regulation of interleukin-17 production	GO:032700	10.0	PRNP, TLR4, TLR2, IFNG
25	aging	GO:007568	9.9	EPO, DCN, TGFB1, CRYAB, FAS, IL1B
26	response to heat	GO:009408	9.9	SOD1, OSM, IL1B, MICA, MMP9, CD14
27	innate immune response	GO:045087	9.9	PCBP2, F12, PYCARD, CTSK, CTSB, RPS27A
28	positive regulation of interleukin-12 production	GO:032735	9.8	TLR4, TLR2, IFNG, CD40, CD40LG
29	extracellular matrix organization	GO:030198	9.8	GFAP, FURIN, MMP3, MMP9, APBB1, APLP1
30	response to ethanol	GO:045471	9.8	SOD1, TLR4, CTSB, TNFRSF1A, CCND1, GSN
31	activation of MAPK activity	GO:000187	9.7	HGF, C5, SOD1, TLR4, RPS27A, TNF
32	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.6	IL1B, IFNG, TNF
33	cytokine-mediated signaling pathway	GO:019221	9.6	CSF3, RPS27A, TNFRSF1A, HLA-DRB1, HLA-B, HLA-A
34	anti-apoptosis	GO:006916	9.6	RPS27A, NFKB1, PSEN1, PRNP, SOD1, HGF
35	positive regulation of cytokine secretion	GO:050715	9.6	TLR2, TNF, INS, CD14, SAA1
36	induction of apoptosis	GO:006917	9.5	C5, TGFB1, TLR2, NLRP3, PYCARD, TNF
37	inflammatory response	GO:006954	9.4	CRP, NLRP3, NFKB1, AGER, TLR2, TGFB1
38	response to hypoxia	GO:001666	9.4	CRYAB, TLR4, TGFB1, PSEN2, NPPB, CRP
39	positive regulation of cell proliferation	GO:008284	9.3	OSM, OSMR, CSF2, CSF3, ADAM10, EPO
40	MAPK cascade	GO:000165	9.3	TGFB1, TNF, MAPKAPK5, IL31RA, IL1B, FGFR3
41	immune response	GO:006955	9.3	HLA-B, HLA-DRB1, TLR2, TLR4, OSM, CSF2
42	platelet degranulation	GO:002576	9.1	ALB, A2M, TGFB1, TF, SOD1, HGF
43	platelet activation	GO:030168	9.1	F8, F5, ALB, A2M, TGFB1, TF
44	positive regulation of nitric oxide biosynthetic process	GO:045429	9.0	TLR4, TLR2, TNF, IFNG, IL1B, INS
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.9	HGF, OSM, TLR4, TP53, IL6, IL3
46	apoptotic process	GO:006915	8.9	RPS27A, TNFRSF1A, TNF, TP53, NFKB1, OSM
47	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	NLRP3, NFKB1, AGER, TLR2, TLR4, TGFB1
48	response to drug	GO:042493	8.5	CALR, TNF, SNCA, ABCC6, TGFB1, TGIF1
49	positive regulation of apoptotic process	GO:043065	8.3	IL1B, APBB1, FAS, TP53, TNF, PYCARD
50	blood coagulation	GO:007596	8.1	ALB, F10, F12, TP53, A2M, ACTG1

Molecular functions related to amyloidosis according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylcholine-sterol O-acyltransferase activator activity	GO:060228	10.8	APOE, APOA4, APOA2, APOA1
2	beta-amyloid binding	GO:001540	10.8	CST3, APOE, APOA1, APBB1, FBXO2, ITM2B
3	heparin binding	GO:008201	10.7	LTF, APP, APOE, APLP2, APLP1, LPL
4	peptide binding	GO:042277	10.6	CTSB, CALR, IDE, ANPEP, MME, FURIN
5	serine-type endopeptidase inhibitor activity	GO:004867	10.6	A2M, APP, APLP2, FURIN, SERPINA3, SERPINF2
6	integrin binding	GO:005178	10.5	ADAM10, TGFBI, GFAP, CALR, ICAM3, MFGE8
7	endopeptidase activity	GO:004175	10.5	ADAM10, PSEN1, MME, FURIN, PAPPA
8	receptor binding	GO:005102	10.2	HLA-B, NPPA, NPPB, C5, ADAM10, GBA
9	eukaryotic cell surface binding	GO:043499	10.1	EPO, TGFB1, MBL2, APOA4, FGA, SERPINF2
10	receptor activity	GO:004872	9.8	TACSTD2, LRP1, RET, CD40, FPR1, FAS
11	cytokine activity	GO:005125	9.6	CSF3, CSF2, OSM, TNF, IFNG, IFNA2
12	hormone activity	GO:005179	9.6	HAMP, NPPB, NPPA, TTR, IAPP, INS
13	identical protein binding	GO:042802	9.4	HSPB8, TP53, TNF, SNCA, ACTG1, SYP
14	protein homodimerization activity	GO:042803	9.4	HSPB6, PYCARD, CRP, CRYAB, NFKB1, TGFB1
15	protease binding	GO:002020	9.2	CST3, TNFRSF1A, TNF, TP53, IL1R1, INS
16	copper ion binding	GO:005507	9.0	SOD1, PRNP, DBH, SNCA, TP53, ALB
17	chaperone binding	GO:051087	8.9	SOD1, PRNP, TP53, CALR, ALB, PARK2
18	enzyme binding	GO:019899	8.5	BACE1, CD40, APOA1, MAPT, CCND1, TP53
19	protein binding	GO:005515	4.5	F5, TNF, TNFRSF1A, TNNI3, PYCARD, DMPK