MCID: AMY009
MIFTS: 39

Amyloidosis Aa malady

Categories: Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Genetic diseases, Metabolic diseases, Cardiovascular diseases, Immune diseases, Blood diseases

Aliases & Classifications for Amyloidosis Aa

Aliases & Descriptions for Amyloidosis Aa:

Name: Amyloidosis Aa 50
Aa Amyloidosis 50 56 29 69
Reactive Systemic Amyloidosis 69
Inflammatory Amyloidosis 56
Amyloid a Amyloidosis 50
Secondary Amyloidosis 56
Amyloidosis Secondary 52
Reactive Amyloidosis 56

Characteristics:

Orphanet epidemiological data:

56
aa amyloidosis
Inheritance: Multigenic/multifactorial;

Classifications:



External Ids:

Orphanet 56 ORPHA85445
UMLS via Orphanet 70 C0221014
ICD10 via Orphanet 34 E85.3

Summaries for Amyloidosis Aa

NIH Rare Diseases : 50 amyloidosis is a group of diseases in which a protein, called amyloid, builds up in the body's organs and tissues. amyloidosis aa is also referred to as secondary amyloidosis or inflammatory amyloidosis. this disease is caused by a long-lasting infection or inflammatory disease such as rheumatoid arthritis, familial mediterranean fever, or osteomyelitis. infection or inflammation in the body causes an increased amount of a specific protein called serum amyloid a (saa) protein. in this disease, part of the saa protein forms deposits called "amyloid fibrils". these desposits occur in the space around the cells of certain tissues of the body. amyloidosis aa usually begins as a disease in the kidneys, but other organs can be affected such as the liver and spleen. medical or surgical treatment of the underlying infection or inflammatory disease can slow down or stop the progression of this condition. last updated: 1/3/2014

MalaCards based summary : Amyloidosis Aa, also known as aa amyloidosis, is related to amyloidosis, hereditary, transthyretin-related and muckle-wells syndrome. An important gene associated with Amyloidosis Aa is SAA1 (Serum Amyloid A1), and among its related pathways/superpathways are Folate Metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Flutamide and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and spleen, and related phenotype is homeostasis/metabolism.

Related Diseases for Amyloidosis Aa

Diseases in the Amyloidosis family:

Amyloidosis, Hereditary, Transthyretin-Related Al Amyloidosis
Amyloidosis Aa Hereditary Amyloidosis
Primary Localized Amyloidosis Ah Amyloidosis

Diseases related to Amyloidosis Aa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Related Disease Score Top Affiliating Genes
1 amyloidosis, hereditary, transthyretin-related 11.0
2 muckle-wells syndrome 10.9
3 periodic fever, familial 10.9
4 familial mediterranean fever, ar 10.9
5 multiple myeloma 10.4
6 urethral obstruction sequence 10.3 CRP SAA4
7 diverticulitis of colon 10.3 CRP SAA1
8 immunodeficiency 9 10.3 CRP SAA1
9 cutaneous sclerosis 10.3 CRP SAA4
10 cellulitis 10.2 SAA1 TTR
11 retinal cancer 10.2 CRP MEFV
12 mechanical lagophthalmos 10.2 CRP MEFV
13 cyclotropia 10.2 CRP MEFV
14 cataract 10.2 CRP TTR
15 cinca syndrome 10.2 CRP MEFV
16 dermatomycosis 10.2 CRP MEFV
17 erythema infectiosum 10.2 CRP TTR
18 choriodal dystrophy, central areolar 2 10.2 B2M TTR
19 hidradenitis 10.2 CRP MEFV
20 bacteriuria 10.2 B2M TTR
21 anaplastic ependymoma 10.2 APOA1 TTR
22 esotropia 10.2 CRP MEFV
23 denture stomatitis 10.2 B2M TTR
24 tibial nerve palsy 10.2 B2M TTR
25 childhood vagina botryoid rhabdomyosarcoma 10.2 B2M TTR
26 pyloric stenosis, infantile hypertrophic, 2 10.2 CRP MEFV SAA1
27 female infertility of uterine origin 10.2 LCAT TTR
28 pancreatic vasoactive intestinal peptide producing tumor 10.2 B2M TTR
29 generalized dystonia 10.2 CRP MEFV
30 hypotrichosis 6 10.1 B2M TTR
31 hemorrhoid 10.1 B2M CRP
32 alopecia-mental retardation syndrome 3 10.1 APOA1 TTR
33 benign neonatal seizures 10.1 CRP MEFV
34 arena syndrome 10.1 APOA1 LCAT
35 glycogen storage disease viii 10.1 B2M CRP
36 joint disorders 10.1 APOA1 CRP
37 familial progressive cardiac conduction defect 10.1 APOA1 LCAT
38 tyrosinemia, type ii 10.1 APOA1 LCAT
39 amyloidosis 10.1
40 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.1 CRP TTR
41 spastic entropion 10.1 CRP TTR
42 acute female pelvic peritonitis 10.1 LPA TTR
43 chronic myocardial ischemia 10.1 B2M CRP TTR
44 body dysmorphic disorder 10.0 APOA1 CRP TTR
45 hereditary lymphedema type ii 10.0 APOA1 B2M TTR
46 albinism, oculocutaneous, type v 10.0 APOA1 LPA
47 alzheimer disease 19, late onset 10.0 LCAT LPA
48 skin squamous cell carcinoma 9.9 APOA1 LPA
49 spinocerebellar ataxia 20 9.9 APOA1 LPA
50 fetal warfarin syndrome 9.9 APOA1 LCAT

Graphical network of the top 20 diseases related to Amyloidosis Aa:



Diseases related to Amyloidosis Aa

Symptoms & Phenotypes for Amyloidosis Aa

MGI Mouse Phenotypes related to Amyloidosis Aa:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 APOA1 B2M CRP CTSB LCAT MEFV

Drugs & Therapeutics for Amyloidosis Aa

Drugs for Amyloidosis Aa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Flutamide Approved Phase 3 13311-84-7 3397
2
Goserelin Approved Phase 3 65807-02-5 47725 5311128
3
Bicalutamide Approved Phase 3 90357-06-5 56069 2375
4
Buserelin Approved Phase 3 57982-77-1
5
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
6
Creatine Approved, Nutraceutical Phase 3 57-00-1 586
7 Triptorelin Pamoate Phase 3
8 Hormone Antagonists Phase 3
9 Androgen Antagonists Phase 3
10 Androgens Phase 3
11 Hormones Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
13 Antineoplastic Agents, Hormonal Phase 3
14
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
15 Anti-Bacterial Agents Phase 2
16 Anti-Infective Agents Phase 2
17 Antimalarials Phase 2
18 Antiparasitic Agents Phase 2
19 Antiprotozoal Agents Phase 2
20
Bexarotene Approved, Investigational Phase 1 153559-49-0 82146
21 Protective Agents Phase 1
22 Orange Nutraceutical Phase 1
23
Edetic Acid Approved, Vet_approved 60-00-4, 62-33-9 6049
24
Colchicine Approved 64-86-8 6167 2833
25 Pentetic Acid
26 Fluorodeoxyglucose F18
27 Radiopharmaceuticals

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 Efficacy and Safety Study of KIACTA in Preventing Renal Function Decline in AA Amyloidosis Completed NCT01215747 Phase 3
2 Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis Completed NCT00035334 Phase 2, Phase 3
3 Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer Active, not recruiting NCT00567580 Phase 3
4 Safety and Effect of Doxycycline in Patients With Amyloidosis Completed NCT01677286 Phase 2
5 A Study to Evaluate the Effect of Bexarotene on Beta-Amyloid and Apolipoprotein E Metabolism in Healthy Subjects Completed NCT02061878 Phase 1
6 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Unknown status NCT00933296
7 Recurrent AA Amyloidosis After Renal Transplantation Completed NCT02704065
8 Clinical Outcomes and Safety: A Registry Study of Ilaris (Canakinumab) Patients Completed NCT01213641
9 African American Alzheimer's Progression Markers - CSF and Neuro-Imaging Completed NCT02089555
10 Brain Characterization of Amyloid Protein and Glucose Metabolism of ALFA Project Participants Recruiting NCT02685969
11 Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People Recruiting NCT02669225 Early Phase 1
12 Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis Recruiting NCT02798705
13 BEAM: Brain-Eye Amyloid Memory Study Recruiting NCT02524405
14 Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease Recruiting NCT02137460
15 Progression of Renal Amyloidosis of FMF and Relation to Serum SAA Level Not yet recruiting NCT01168570

Search NIH Clinical Center for Amyloidosis Aa

Genetic Tests for Amyloidosis Aa

Genetic tests related to Amyloidosis Aa:

id Genetic test Affiliating Genes
1 Aa Amyloidosis 29

Anatomical Context for Amyloidosis Aa

MalaCards organs/tissues related to Amyloidosis Aa:

39
Liver, Kidney, Spleen, Bone

Publications for Amyloidosis Aa

Articles related to Amyloidosis Aa:

id Title Authors Year
1
Fatal systemic amyloidosis (AA type) in two sisters with dystrophic epidermolysis bullosa. ( 7615888 )
1995
2
Reversal of nephrotic syndrome due to reactive amyloidosis (AA-type) after excision of localized Castleman's disease. ( 7910717 )
1994
3
Pulmonary nodules due to reactive systemic amyloidosis (AA) in Crohn's disease. ( 8303644 )
1993
4
Secondary amyloidosis (AA). ( 1474356 )
1992
5
Amyloidosis (AA type) with gastrointestinal involvement: resolution of gastric amyloid deposition in parallel with disappearance of the serum component of amyloid A protein. ( 2232367 )
1990
6
Resolution of amyloidosis (AA type) complicating chronic ulcerative colitis. ( 3396825 )
1988
7
Amyloidosis (AA type) associated with nodular nonsuppurative panniculitis. ( 6625383 )
1983

Variations for Amyloidosis Aa

Expression for Amyloidosis Aa

Search GEO for disease gene expression data for Amyloidosis Aa.

Pathways for Amyloidosis Aa

Pathways related to Amyloidosis Aa according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 APOA1 CRP SAA1 SAA2 SAA4
2 10.6 APOA1 TTR

GO Terms for Amyloidosis Aa

Cellular components related to Amyloidosis Aa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 APOA1 B2M CRP CTSB LCAT SAA1
2 extracellular region GO:0005576 9.81 APOA1 B2M CRP CTSB LCAT LPA
3 extracellular space GO:0005615 9.61 APOA1 B2M CRP CTSB LCAT SAA1
4 endocytic vesicle lumen GO:0071682 9.32 APOA1 SAA1
5 high-density lipoprotein particle GO:0034364 9.02 APOA1 LCAT SAA1 SAA2 SAA4

Biological processes related to Amyloidosis Aa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.56 APOA1 B2M SAA1 TTR
2 negative regulation of inflammatory response GO:0050728 9.5 APOA1 MEFV SAA1
3 phosphatidylcholine biosynthetic process GO:0006656 9.48 APOA1 LCAT
4 cholesterol transport GO:0030301 9.46 APOA1 LCAT
5 reverse cholesterol transport GO:0043691 9.43 APOA1 LCAT
6 high-density lipoprotein particle remodeling GO:0034375 9.4 APOA1 LCAT
7 lipoprotein biosynthetic process GO:0042158 9.37 APOA1 LCAT
8 lipoprotein metabolic process GO:0042157 9.33 APOA1 LCAT LPA
9 positive chemotaxis GO:0050918 9.13 SAA1 SAA2 SAA4
10 acute-phase response GO:0006953 8.92 CRP SAA1 SAA2 SAA4

Molecular functions related to Amyloidosis Aa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 8.8 SAA1 SAA2 SAA4

Sources for Amyloidosis Aa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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