MCID: AMY009
MIFTS: 23

Amyloidosis Aa malady

Summaries for Amyloidosis Aa

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Amyloidosis is a group of diseases in which a protein, called amyloid, builds up in the body's organs and tissues. amyloidosis aa is also referred to as secondary amyloidosis or inflammatory amyloidosis. this disease is caused by a long-lasting infection or inflammatory disease such as rheumatoid arthritis, familial mediterranean fever, or osteomyelitis. infection or inflammation in the body causes an increased amount of a specific protein called serum amyloid a (saa) protein. in this disease, part of the saa protein forms deposits called "amyloid fibrils". these desposits occur in the space around the cells of certain tissues of the body. amyloidosis aa usually begins as a disease in the kidneys, but other organs can be affected such as the liver and spleen. medical or surgical treatment of the underlying infection or inflammatory disease can slow down or stop the progression of this condition. last updated: 1/3/2014

MalaCards: Amyloidosis Aa, also known as amyloid a amyloidosis, is related to amyloidosis and macroglobulinemia. An important gene associated with Amyloidosis Aa is B2M (beta-2-microglobulin), and among its related pathways are Interferon Signaling and Allograft rejection. The compounds pamidronate and pmma have been mentioned in the context of this disorder. Affiliated tissues include spleen, kidney and liver.

Aliases & Classifications for Amyloidosis Aa

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42NIH Rare Diseases
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Aliases & Descriptions:

amyloidosis aa 42
amyloid a amyloidosis 42
aa amyloidosis 42


Related Diseases for Amyloidosis Aa

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Amyloidosis Aa:



Diseases related to amyloidosis aa

Clinical Features for Amyloidosis Aa

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Drugs & Therapeutics for Amyloidosis Aa

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Amyloidosis Aa

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Anatomical Context for Amyloidosis Aa

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32MalaCards
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MalaCards organs/tissues related to Amyloidosis Aa:

32
Spleen, Kidney, Liver

Animal Models for Amyloidosis Aa or affiliated genes

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Publications for Amyloidosis Aa

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Genetic Variations for Amyloidosis Aa

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Expression for genes affiliated with Amyloidosis Aa

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyloidosis Aa

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Pathways for genes affiliated with Amyloidosis Aa

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53Reactome, 29KEGG
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Pathways related to Amyloidosis Aa according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1IL6, B2M
2
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9.1IL6, B2M

Compounds for genes affiliated with Amyloidosis Aa

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Amyloidosis Aa according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1pamidronate44 49 1111.4IL6, B2M
2pmma449.4IL6, B2M
32,5-oligoadenylate449.4IL6, B2M
4neopterin449.4B2M, IL6
5rituximab44 49 1111.4IL6, B2M
6pge1449.4IL6, B2M
7thalidomide44 49 59 1112.3IL6, B2M
8hyaluronic acid44 2410.3B2M, IL6
9calcitriol44 59 11 2412.3IL6, B2M
10indomethacin44 59 28 1112.2IL6, B2M
11vitamin d449.2IL6, B2M
12genistein44 28 59 2 11 2414.1B2M, IL6
13lactate449.1IL6, B2M
14cyclosporin a44 28 5911.0IL6, B2M
15pge2448.8IL6, B2M

GO Terms for genes affiliated with Amyloidosis Aa

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16Gene Ontology
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Cellular components related to Amyloidosis Aa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IL6, B2M

Biological processes related to Amyloidosis Aa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424939.1IL6, B2M
2cytokine-mediated signaling pathwayGO:0192218.8IL6, B2M

Products for genes affiliated with Amyloidosis Aa

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amyloidosis Aa

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet