MCID: AMY009
MIFTS: 26

Amyloidosis Aa malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Metabolic diseases, Cardiovascular diseases, Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Amyloidosis Aa

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Sources:
45NIH Rare Diseases, 51Orphanet, 24GTR, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Amyloidosis Aa:

Name: Amyloidosis Aa 45
Aa Amyloidosis 45 51 24 65
Reactive Systemic Amyloidosis 65
Inflammatory Amyloidosis 51
 
Secondary Amyloidosis 51
Amyloid a Amyloidosis 45
Reactive Amyloidosis 51

Classifications:



External Ids:

Orphanet51 85445
ICD10 via Orphanet28 E85.3
UMLS via Orphanet66 C0221014
UMLS65 C0221014, C3536715

Summaries for Amyloidosis Aa

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NIH Rare Diseases:45 Amyloidosis is a group of diseases in which a protein, called amyloid, builds up in the body's organs and tissues. amyloidosis aa is also referred to as secondary amyloidosis or inflammatory amyloidosis. this disease is caused by a long-lasting infection or inflammatory disease such as rheumatoid arthritis, familial mediterranean fever, or osteomyelitis. infection or inflammation in the body causes an increased amount of a specific protein called serum amyloid a (saa) protein. in this disease, part of the saa protein forms deposits called "amyloid fibrils". these desposits occur in the space around the cells of certain tissues of the body. amyloidosis aa usually begins as a disease in the kidneys, but other organs can be affected such as the liver and spleen. medical or surgical treatment of the underlying infection or inflammatory disease can slow down or stop the progression of this condition. last updated: 1/3/2014

MalaCards based summary: Amyloidosis Aa, also known as aa amyloidosis, is related to amyloidosis, hereditary, transthyretin-related and muckle-wells syndrome. An important gene associated with Amyloidosis Aa is SAA1 (Serum Amyloid A1), and among its related pathways are Folate Metabolism and Selenium Pathway. Affiliated tissues include spleen, kidney and liver, and related mouse phenotype homeostasis/metabolism.

Related Diseases for Amyloidosis Aa

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Diseases in the Amyloidosis family:

Amyloidosis, Hereditary, Transthyretin-Related Al Amyloidosis
amyloidosis aa Hereditary Amyloidosis
Primary Localized Amyloidosis Ah Amyloidosis
Acys Amyloidosis

Diseases related to Amyloidosis Aa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis, hereditary, transthyretin-related10.5
2muckle-wells syndrome10.5
3periodic fever, familial10.5
4familial mediterranean fever, ar10.5
5septicemic plague10.4SAA1, TTR
6postauricular lymphadenitis10.4CRP, MEFV
7rhinoscleroma10.4CRP, MEFV
8diffuse secondary choroid atrophy10.3CRP, MEFV
9calpainopathy10.3CRP, TTR
10peripheral artery disease10.3CRP, MEFV
11diarrhea10.3CRP, SAA1
12ureteral disease10.3CRP, MEFV
13in situ carcinoma10.3CRP, TTR
14gonadal disease10.3CRP, MEFV
15partial circumpapillary choroid dystrophy10.3CRP, MEFV
16lupus erythematosus10.3
17acute allergic mucoid otitis media10.3B2M, CRP
18toxic shock syndrome10.3B2M, TTR
19macular keratitis10.3B2M, TTR
20common peroneal nerve lesion10.3B2M, TTR
21chest wall lymphoma10.3B2M, TTR
22tuberculoid leprosy10.3CRP, MEFV
23spondylocamptodactyly10.3B2M, CRP
24narcissistic personality disorder10.3B2M, CRP
25salpingitis isthmica nodosa10.3B2M, TTR
26blue color blindness10.3CRP, MEFV
27amyloidosis aa10.2APOA1, TTR
28alopecia-mental retardation syndrome 310.2B2M, TTR
29postsurgical hypothyroidism10.2B2M, TTR
30endocarditis10.2B2M, CRP
31ischemic optic neuropathy10.2APOA1, CRP
32cholestasis10.2LCAT, TTR
33hereditary antithrombin deficiency10.2APOA1, TTR
34carpal tunnel syndrome, familial10.2APOA1, TTR
35familial mediterranean fever, ad10.2CRP, MEFV, SAA1
36systemic lupus erythematosus10.2
37peyronie's disease10.2
38arthritis10.2
39hepatitis10.2
40hepatitis b10.2
41adenocarcinoma10.2
42al gazali aziz salem syndrome10.2B2M, TTR
43malignant cardiac peripheral nerve sheath neoplasm10.2B2M, TTR
44spinocerebellar ataxia 410.2APOA1, LCAT
45leech infestation10.2CRP, MEFV
46keratomalacia10.2B2M, CRP
47adult endodermal sinus tumor10.2APOA1, TTR
48small intestinal vasoactive intestinal peptide producing tumor10.2B2M, TTR
49clear cell squamous cell skin carcinoma10.1B2M, CRP, MEFV
50atheroembolism of kidney10.1CRP, LCAT

Graphical network of the top 20 diseases related to Amyloidosis Aa:



Diseases related to amyloidosis aa

Symptoms for Amyloidosis Aa

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Drugs & Therapeutics for Amyloidosis Aa

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Drugs for Amyloidosis Aa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Creatineapproved, nutraceuticalPhase 311057-00-1586
Synonyms:
((amino(Imino)methyl)(methyl)amino)acetic acid
((amino(imino)methyl)(methyl)amino)acetate
((amino(imino)methyl)(methyl)amino)acetic acid
(N-methylcarbamimidamido)acetic acid
(alpha-Methylguanido)acetate
(alpha-Methylguanido)acetic acid
(α-methylguanido)acetic acid
Cosmocair C 100
Creatin
Creatine
Creatine hydrate
Kreatin
 
Krebiozon
Methylglycocyamine
Methylguanidoacetate
Methylguanidoacetic acid
N-(Aminoiminomethyl)-N-Methyl-Glycine
N-(aminoiminomethyl)-N-methylglycine
N-Amidinosarcosine
N-Carbamimidoyl-N-methylglycine
N-Methyl-N-guanylglycine
N-[(e)-AMINO(imino)methyl]-N-methylglycine
Phosphagen
[[Amino(imino)methyl](methyl)amino]acetate
[[Amino(imino)methyl](methyl)amino]acetic acid
alpha-Methylguanidino acetic acid
2
Doxycyclineapproved, investigationalPhase 2219564-25-054671203, 5281011
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Adoxa
Alodox
Alti-Doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Doryx
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy 100
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline
Doxycycline (200mg/day) or Placebo
Doxycycline (INN)
 
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline hydrochloride
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
Morgidox
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Ocudox
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Monohydrate
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline
3Antiparasitic AgentsPhase 21854
4Antiprotozoal AgentsPhase 21730
5AntimalarialsPhase 21058
6Anti-Infective AgentsPhase 217220
7Anti-Bacterial AgentsPhase 29140
8
Colchicineapproved10464-86-86167, 2833
Synonyms:
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
30512-31-3
5843-86-7
64-86-8
7-alpha-H-Colchicine
7.alpha.H-Colchicine
7alphaH-Colchicine
AC1L1LXO
ACon1_000353
AI3-31149
AKOS001582887
BB_NC-0737
BPBio1_000535
BRD-K00259736-001-06-5
BSPBio_000485
BSPBio_002083
Benzo(a)heptalen-9(5H)-one
C 9754
C07592
C22H25NO6
C3915_SIGMA
C9754_SIGMA
CCRIS 691
CHEBI:27882
CHEMBL107
CID6167
CPD-9785
Colchicin
Colchicin [German]
Colchicina
Colchicina [Italian]
Colchicine
Colchicine (JP15/USP)
Colchicine (TN)
Colchicine [JAN]
Colchicine, (+-)-Isomer
Colchicine, (R)-Isomer
Colchicine, Colchicum autumnale
Colchicinum
Colchineos
Colchisol
Colchysat
Colcin
Colcrys
Colsaloid
Colstat
Condylon
D003078
D00570
DB01394
DB08117
DivK1c_000753
EINECS 200-598-5
EU-0100310
Goutnil
HMS1569I07
HMS1920A08
HMS2091G16
HMS502F15
HSDB 3044
IDI1_000753
KBio1_000753
KBio2_001322
KBio2_003890
KBio2_006458
 
KBio3_001303
KBioGR_000856
KBioSS_001322
Kolkicin
LOC
LS-279
Lopac0_000310
MEGxp0_001879
MLS001055448
MLS001055448-02
MLS001304089
MLS002153786
MPC-004
Mitigare
MolPort-001-742-594
N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide
N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide
N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide
N-Acetyl trimethylcolchicinic acid methylether
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
NCGC00025125-01
NCGC00025125-02
NCGC00025125-03
NCGC00025125-04
NCGC00025125-05
NCGC00025125-06
NCGC00025125-07
NCGC00025125-11
NCGC00169157-01
NCGC00169157-02
NCGC00169157-03
NCI60_041659
NChemBio.2007.10-comp20
NINDS_000753
NSC 757
NSC757
Prestwick0_000363
Prestwick1_000363
Prestwick2_000363
Prestwick3_000363
Prestwick_695
S2284_Selleck
SDCCGMLS-0066633.P001
SID26747941
SID49671357
SMR000058323
SPBio_000289
SPBio_002406
SPECTRUM1500205
Spectrum2_000075
Spectrum3_000362
Spectrum4_000298
Spectrum5_000787
Spectrum_000842
Tocris-1364
UNII-SML2Y3J35T
UPCMLD-DP065
UPCMLD-DP065:001
WLN: L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1
ZINC00621853
binds to tubulin
colchicine
inhibits microtubular assembly
nchembio853-comp2
spindle poison

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety Study of KIACTA in Preventing Renal Function Decline in AA AmyloidosisCompletedNCT01215747Phase 3
2Study of the Safety and Efficacy of NC-503 in Secondary (AA) AmyloidosisCompletedNCT00035334Phase 2, Phase 3
3Safety and Effect of Doxycycline in Patients With AmyloidosisActive, not recruitingNCT01677286Phase 2
4Clinical Outcomes and Safety: A Registry Study of Ilaris (Canakinumab) PatientsCompletedNCT01213641
5Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic FactorsRecruitingNCT00933296
6Recurrent AA Amyloidosis After Renal TransplantationEnrolling by invitationNCT02704065
7Progression of Renal Amyloidosis of FMF and Relation to Serum SAA LevelNot yet recruitingNCT01168570

Search NIH Clinical Center for Amyloidosis Aa

Genetic Tests for Amyloidosis Aa

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Anatomical Context for Amyloidosis Aa

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MalaCards organs/tissues related to Amyloidosis Aa:

33
Spleen, Kidney, Liver, Bone, Lung, Pituitary

Animal Models for Amyloidosis Aa or affiliated genes

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MGI Mouse Phenotypes related to Amyloidosis Aa:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.9APOA1, B2M, CRP, CTSB, LCAT, MEFV

Publications for Amyloidosis Aa

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Articles related to Amyloidosis Aa:

idTitleAuthorsYear
1
Successful management of a posterior saccular coronary artery aneurysm at the left main coronary artery bifurcation. (20459453)
2011
2
Comparison between regional micropush-out and microtensile bond strength of resin composite to dentin. (18446547)
2008
3
A general and fast scoring function for protein-ligand interactions: a simplified potential approach. (10072678)
1999
4
Lack of normal MR enhancement of the pituitary gland: findings in three siblings with combined pituitary hormone deficiency. (9504480)
1998
5
Interleukin 6 and interferon-gamma gene expression in lung transplant recipients with refractory acute cellular rejection: implications for monitoring and inhibition by treatment with aerosolized cyclosporine. (9256185)
1997
6
Hereditary brachydactyly associated with hypertension. (4774535)
1973
7

Variations for Amyloidosis Aa

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Expression for genes affiliated with Amyloidosis Aa

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Search GEO for disease gene expression data for Amyloidosis Aa.

Pathways for genes affiliated with Amyloidosis Aa

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GO Terms for genes affiliated with Amyloidosis Aa

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Biological processes related to Amyloidosis Aa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:000695310.0SAA2, SAA4
2defense response to Gram-positive bacteriumGO:00508309.8B2M, CRP
3reverse cholesterol transportGO:00436919.7APOA1, LCAT
4retinoid metabolic processGO:00015239.5APOA1, TTR
5phosphatidylcholine biosynthetic processGO:00066569.3APOA1, LCAT
6high-density lipoprotein particle remodelingGO:00343759.1APOA1, LCAT

Sources for Amyloidosis Aa

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet