CAA
MCID: AMY012
MIFTS: 22

Amyloidosis Cerebral (CAA) malady

Summaries for Amyloidosis Cerebral

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33MalaCards
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MalaCards: Amyloidosis Cerebral, also known as senile cerebral amyloid angiopathy, is related to hemorrhage, intracerebral and alzheimer's disease. An important gene associated with Amyloidosis Cerebral is APP (amyloid beta (A4) precursor protein). Affiliated tissues include brain and liver.

Aliases & Classifications for Amyloidosis Cerebral

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43NIH Rare Diseases
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Aliases & Descriptions:

amyloidosis cerebral 43
senile cerebral amyloid angiopathy 43
cerebral amyloid angiopathy 43
cerebral amyloidosis 43
amyloid angiopathy 43
caa 43


Related Diseases for Amyloidosis Cerebral

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17GeneCards, 18GeneDecks
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Diseases related to Amyloidosis Cerebral via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhage, intracerebral10.8
2alzheimer's disease10.8
3siderosis10.6
4superficial siderosis10.6
5brain disease10.5
6vascular disease10.5
7granulomatous angiitis10.5
8vascular dementia10.5
9down syndrome10.4
10cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.4
11arteriosclerosis10.4
12vasculitis10.4
13cerebral arteriosclerosis10.4
14stroke, hemorrhagic10.4
15al amyloidosis10.3
16cerebral atherosclerosis10.3
17hemosiderosis10.3
18cadasil10.3
19atherosclerosis10.3
20autosomal dominant disease10.3
21dementia familial british10.3
22subcortical arteriosclerotic encephalopathy10.3
23cerebral amyloid angiopathy, prnp-related10.3
24lip disease10.3
25amyloidosis10.2
26spinocerebellar ataxia10.2
27cerebral amyloid angiopathy10.1
28senile systemic amyloidosis10.1
29moyamoya disease10.1
30parkinson's disease10.1
31cerebral arteritis10.1
32mu chain disease10.1
33amyloid tumor10.1
34progressive supranuclear palsy10.1
35apo a-i deficiency10.1
36binswanger's disease10.1
37hereditary cerebral hemorrhage with amyloidosis10.1
38reactive angioendotheliomatosis10.1
39rheumatoid vasculitis10.1
40alzheimer disease risk factor10.1
41familial oculoleptomeningeal amyloidosis10.1
42brain injury10.1
43cerebral hypoxia10.1
44hypoxia10.1
45paresthesia10.1
46traumatic brain injury10.1
47amyloidosis, secondary10.1
48brain ischemia10.1
49dementia pugilistica10.1
50thalassemia10.1

Graphical network of the top 20 diseases related to Amyloidosis Cerebral:



Diseases related to amyloidosis cerebral

Clinical Features for Amyloidosis Cerebral

Drugs & Therapeutics for Amyloidosis Cerebral

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Amyloidosis Cerebral

Anatomical Context for Amyloidosis Cerebral

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33MalaCards
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MalaCards organs/tissues related to Amyloidosis Cerebral:

33
Brain, Liver

Animal Models for Amyloidosis Cerebral or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Amyloidosis Cerebral

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51PubMed
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Articles related to Amyloidosis Cerebral:

(show top 50)    (show all 84)
idTitleAuthorsYear
1
Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. (23399896)
2013
2
Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis. (24034629)
2013
3
Peripherally applied synthetic peptide isoAsp7-AI^(1-42) triggers cerebral I^-amyloidosis. (23670398)
2013
4
Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type. (23267843)
2013
5
White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease? (23420027)
2013
6
Label-free imaging of cerebral I^-amyloidosis with extended-focus optical coherence microscopy. (23077040)
2012
7
Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion. (17629591)
2009
8
CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation. (18055209)
2008
9
Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice. (18640988)
2008
10
Cystatin C modulates cerebral beta-amyloidosis. (18026102)
2007
11
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. (16906128)
2006
12
Fatal cerebral haemorrhage after liver transplantation in a patient with transthyretin variant (gly53glu) amyloidosis. (17122946)
2006
13
Senile systemic amyloidosis, cerebral amyloid angiopathy, and dementia in a very old Finnish population. (17062383)
2006
14
Hereditary cerebral hemorrhage with amyloidosis-Dutch type. (16382777)
2005
15
Microbleeds in hereditary cerebral hemorrhage with amyloidosis-Dutch type. (15824369)
2005
16
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. (16177050)
2005
17
Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. (15014955)
2004
18
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. (15311281)
2004
19
Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D). (12480745)
2002
20
Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice. (12128081)
2002
21
Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles. (11761474)
2001
22
Cellular processing of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. (10524281)
1999
23
Ultrastructural evidence of early non-fibrillar Abeta42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type. (10603032)
1999
24
Instability of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. (9565605)
1998
25
Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D). (9542588)
1998
26
Association of vascular amyloid beta and cells of the mononuclear phagocyte system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer disease. (9056541)
1997
27
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): II--A review of histopathological aspects. (8737927)
1996
28
Cerebral amyloid angiopathy and plaques, and visceral amyloidosis in aged macaques. (8744409)
1996
29
Hereditary cerebral hemorrhage with amyloidosis-Dutch type: better correlation of cognitive deterioration with advancing age than with number of focal lesions or white matter hyperintensities. (8939282)
1996
30
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D. (8955370)
1996
31
The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease. (8943274)
1996
32
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D): I--A review of clinical, radiologic and genetic aspects. (8737926)
1996
33
Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (Dutch). An immunohistochemical study. (7521904)
1994
34
Ubiquitinated neurites are associated with preamyloid and cerebral amyloid beta deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type. (8384771)
1993
35
Hereditary cerebral hemorrhage with amyloidosis-Dutch type. (8240526)
1993
36
Beta protein precursor expression in human platelets and a megakaryocyte cell line. Possible implications for the origin of cerebral amyloidosis in Alzheimer's disease. (1405489)
1992
37
Primary sequence confirmation of the beta-amyloid peptide from hereditary cerebral haemorrhage with amyloidosis (Dutch type) by collisional activation of the doubly charged ion. (1515459)
1992
38
Creutzfeldt-Jakob syndrome--a disease of viral etiology and genetic pathogenesis: transmitted cerebral amyloidosis induced by viral infection]. (1811184)
1991
39
DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type) (1679289)
1991
40
Hereditary cerebral hemorrhage with amyloidosis--Dutch type: its importance for Alzheimer research. (1716015)
1991
41
Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Tc-99m HM-PAO single photon emission computed tomography. (2398939)
1990
42
Hereditary cerebral hemorrhage. Dementia with cystatin C amyloidosis]. (2320403)
1990
43
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). (1971458)
1990
44
Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type. (2396937)
1990
45
Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis--Dutch type. (2274275)
1990
46
Hereditary cerebral hemorrhage with amyloidosis-Dutch type. Clinical and computed tomographic analysis of 24 cases. (2346393)
1990
47
Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. (3281669)
1988
48
Immunohistochemical characterization of the amyloid deposits and quantitation of pertinent cerebrospinal fluid proteins in hereditary cerebral hemorrhage with amyloidosis. (2436360)
1987
49
Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C). (3517880)
1986
50
PRIMARY SYSTEMIC AMYLOIDOSIS; CEREBRAL INVOLVEMENT AND SENILE PLAQUE FORMATION. (14105304)
1964

Genetic Variations for Amyloidosis Cerebral

Expression for genes affiliated with Amyloidosis Cerebral

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyloidosis Cerebral

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Pathways for genes affiliated with Amyloidosis Cerebral

Compounds for genes affiliated with Amyloidosis Cerebral

GO Terms for genes affiliated with Amyloidosis Cerebral

Products for genes affiliated with Amyloidosis Cerebral

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Sources for Amyloidosis Cerebral

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet