Amyloidosis Corneal malady

MalaCards: Amyloidosis Corneal, also known as corneal dystrophy, gelatinous drop-like, is related to lattice corneal dystrophy and lattice corneal dystrophy type 1. An important gene associated with Amyloidosis Corneal is TACSTD2 (tumor-associated calcium signal transducer 2), and among its related pathways is Disease. The drugs acetylcysteine and colchicine and the compounds cytochalasin b and azathioprine have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

OMIM: 204870

amyloidosis corneal 30 corneal dystrophy, gelatinous drop-like 30 16 33 corneal dystrophy, lattice type 3 30 16 amyloid corneal dystrophy, japanese type 30 gelatinous drop-like corneal dystrophy 30 lattice corneal dystrophy type3 30

amyloidosis, corneal 32 corneal amyloidosis 30 amyloidosis 43 cdgdl 30 gdld 30

Diseases related to amyloidosis corneal by text searches and GeneDecks gene sharing:

(show top 50)    (show all 153)

id	Related Disease	Score	Top Affiliating Genes
1	lattice corneal dystrophy	35.0	GSN, TGFBI, TACSTD2
2	lattice corneal dystrophy type 1	32.9	TGFBI, GSN
3	corneal dystrophy	26.5	TACSTD2, TGFBI, LTF, GSN
4	amyloidosis	26.4	TACSTD2, TGFBI, LTF, GSN
5	pancreatitis	26.3	GSN, LTF, TGFBI, TACSTD2
6	recurrent corneal erosion	12.4	TGFBI, TACSTD2
7	gastrointestinal system disease	12.4	LTF, TGFBI
8	cork-handlers' disease	12.3	LTF, TGFBI
9	endometrial adenocarcinoma	12.3	GSN, LTF
10	sepsis	12.3	GSN, LTF
11	corneal disease	12.3	GSN, TGFBI
12	renal clear cell carcinoma	12.3	TGFBI, GSN
13	keratoconus	12.1	GSN, TGFBI
14	amyloid tumor	11.8	GSN, LTF, TGFBI
15	lung carcinoma	11.6	TGFBI, LTF, GSN
16	lattice corneal dystrophy type ii	11.4
17	colon cancer	11.3	GSN, LTF, TGFBI, TACSTD2
18	adenocarcinoma	11.2	GSN, LTF, TGFBI, TACSTD2
19	fibrosis	11.2	GSN, LTF, TGFBI
20	colorectal cancer	11.1	TACSTD2, TGFBI, LTF, GSN
21	breast cancer	10.9	TACSTD2, TGFBI, LTF, GSN
22	transthyretin amyloidosis	9.9
23	hereditary amyloidosis	9.6
24	al amyloidosis	9.3
25	cerebritis	9.3
26	lattice corneal dystrophy type 3a	9.2
27	familial mediterranean fever	9.0
28	familial transthyretin amyloidosis	8.8
29	finnish type amyloidosis	8.7
30	hereditary cerebral hemorrhage with amyloidosis	8.7
31	primary cutaneous amyloidosis	8.6
32	cerebral hemorrhage	8.6
33	arthritis	8.4
34	familial visceral amyloidosis	8.4
35	rheumatoid arthritis	8.4
36	alzheimer's disease	7.9
37	lattice corneal dystrophy type iiia	7.8
38	amyloidosis, secondary	7.7
39	leptomeningeal amyloidosis	7.6
40	periodic fever	7.6
41	polyneuropathy	7.5
42	amyloidosis aa	7.3
43	amyloidosis, renal	7.3
44	anemia	7.3
45	neuropathy	7.1
46	amyloidosis beta2m	6.9
47	dementia	6.7
48	muckle-wells syndrome	6.7
49	multiple endocrine neoplasia	6.7
50	nephrotic syndrome	6.7

Clinical features from OMIM: 204870

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetylcysteine, colchcine, colchicine

Genetic tests related to amyloidosis corneal:

id	Genetic test	Affiliating Genes
1	Amyloidosis Corneal clinical/research	TACSTD2

MGI Mouse Phenotypes related to amyloidosis corneal:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	8.0	GSN, LTF, TGFBI, TACSTD2

Genes related to amyloidosis corneal according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	TACSTD2	tumor-associated calcium signal transducer 2	11.0
2	GSN	gelsolin	11.0
3	TGFBI	transforming growth factor, beta-induced, 68kDa	11.0
4	LTF	lactotransferrin	11.0

Pathways related to amyloidosis corneal according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Disease38	9.1	LTF, TGFBI

Compounds related to amyloidosis corneal according to GeneDecks:

(show all 11)

id	Compound	Score	Top Affiliating Genes
1	cytochalasin b32	9.6	GSN, LTF
2	azathioprine32 34 9 9	12.5	LTF, GSN
3	latex32	9.5	LTF, GSN
4	cytochalasin d32 42	10.4	LTF, GSN
5	endotoxin32	9.3	GSN, LTF
6	polyacrylamide32	9.3	LTF, GSN
7	fmlp32	9.2	LTF, GSN
8	aspartate32	9.0	GSN, TACSTD2, LTF
9	phosphatidylserine32 9 9	11.0	LTF, GSN
10	alanine32	9.0	TACSTD2, LTF, GSN
11	cysteine32	8.6	LTF, TGFBI, GSN

Biological processes related to amyloidosis corneal according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	visual perception	GO:007601	9.1	TGFBI, TACSTD2