AMYL8
MCID: AMY082
MIFTS: 45

Amyloidosis, Familial Visceral (AMYL8) malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Bone diseases, Metabolic diseases, Neuronal diseases

Aliases & Classifications for Amyloidosis, Familial Visceral

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Aliases & Descriptions for Amyloidosis, Familial Visceral:

Name: Amyloidosis, Familial Visceral 52 68
Hereditary Amyloid Nephropathy 48 54 68
Familial Visceral Amyloidosis 11 70 13
Familial Amyloid Nephropathy 48 54 70
Familial Renal Amyloidosis 48 54 70
Ostertag Type Amyloidosis 11 48 70
German Type Amyloidosis 11 48 70
Hereditary Amyloidosis with Primary Renal Involement 48 54
Hereditary Renal Amyloidosis 48 54
Amyloidosis, 3 or More Types 52 12
Amyloidosis, Ostertag Type 48 54
Amyloidosis Viii 48 70
 
Amyloidosis 8 48 70
Systemic Non-Neuropathic Amyloidosis 70
Amyloidosis, Systemic Nonneuropathic 50
Systemic Nonneuropathic Amyloidosis 11
Amyloidosis Systemic Nonneuropathic 48
Amyloidosis Familial Visceral 48
Amyloidosis, Familial Renal 11
Amyloidosis Familial Renal 48
Amyloid Nephropathy 68
Amyloidosis, Renal 52
Renal Amyloidosis 50
Amyl8 70

Characteristics:

Orphanet epidemiological data:

54
hereditary amyloid nephropathy:
Inheritance: Autosomal dominant; Age of onset: All ages

HPO:

64
amyloidosis, familial visceral:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM52 105200
Disease Ontology11 DOID:0050636
Orphanet54 ORPHA85450
ICD10 via Orphanet31 E85.0
MedGen37 C0268389
MeSH39 D028226

Summaries for Amyloidosis, Familial Visceral

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UniProtKB/Swiss-Prot:70 Amyloidosis 8: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.

MalaCards based summary: Amyloidosis, Familial Visceral, also known as hereditary amyloid nephropathy, is related to muckle-wells syndrome and apoa1-related familial visceral amyloidosis, and has symptoms including proteinuria, nephrotic syndrome and nephropathy. An important gene associated with Amyloidosis, Familial Visceral is FGA (Fibrinogen Alpha Chain), and among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF) and Advanced glycosylation endproduct receptor signaling. Affiliated tissues include skin, kidney and bone, and related mouse phenotypes are liver/biliary system and integument.

Wikipedia:71 Familial renal amyloidosis (or familial visceral amyloidosis, or hereditary amyloid nephropathy) is a... more...

Description from OMIM:52 105200

Related Diseases for Amyloidosis, Familial Visceral

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Diseases in the Amyloidosis, Familial Visceral family:

Apoa1-Related Familial Visceral Amyloidosis Fga-Related Familial Visceral Amyloidosis
Lyz-Related Familial Visceral Amyloidosis

Diseases related to Amyloidosis, Familial Visceral via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1muckle-wells syndrome31.8MEFV, TNFRSF1A
2apoa1-related familial visceral amyloidosis12.0
3fga-related familial visceral amyloidosis12.0
4lyz-related familial visceral amyloidosis12.0
5familial progressive cardiac conduction defect10.3APOA1, APOA2
6tyrosinemia, type ii10.2APOA1, APOA2
7choriodal dystrophy, central areolar 210.2B2M, LYZ, TTR
8oligoarticular juvenile idiopathic arthritis with anti-nuclear antibodies10.2MEFV, TNFRSF1A
9spondylocostal dysostosis-hypospadias-intellectual disability syndrome10.2MEFV, TNFRSF1A
10arthrogryposis, lethal, with anterior horn cell disease10.2GSN, TTR
11anaplastic ependymoma10.1APOA1, GSN, TTR
12alopecia-mental retardation syndrome 310.1APOA1, GSN, TTR
13candidiasis, familial, 4, autosomal recessive10.1MEFV, TNFRSF1A
14amyloidosis10.1
15malignant perineurioma10.1MEFV, TNFRSF1A
16acute female pelvic peritonitis10.1LPA, TTR
17cellulitis10.1GSN, SAA1, TTR
18albinism, oculocutaneous, type v10.1APOA1, APOA2, LPA
19pyloric stenosis, infantile hypertrophic, 210.1MEFV, SAA1, TNFRSF1A
20bird fancier's lung10.1APOA1, APOA2, LPA
21stone in bladder diverticulum10.0APOA1, APOA2, LPA
22von willebrand disease, platelet-type10.0APOA1, APOA2, LPA
23neuropathy, hereditary sensory and autonomic, type ia10.0APOA1, APOA2, LPA
24hypertriglyceridemia10.0APOA1, APOA2, LPA
25immunodeficiency 1810.0APOA1, APOA2, LPA
26body dysmorphic disorder10.0APOA1, IAPP, TTR
27conjunctival vascular disease10.0APP, LYZ, TNFRSF1A
28diverticulitis of colon10.0APP, SAA1
29ectodermal dysplasia mental retardation syndactyly9.9APP, PSEN1
30immunodeficiency 99.9SAA1, TNFRSF1A
31foxp2-related speech and language disorders9.9APP, PSEN1
32limited scleroderma9.9APP, PSEN1, TTR
33encephalitozoonosis9.8APP, PSEN1
34hereditary lymphedema type ii9.8APOA1, APOA2, B2M, FGA, GSN, LYZ
35polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract9.7APP, GSN, PSEN1, TTR
36factor x deficiency9.5
37glomerulonephritis9.5
38renal oncocytoma9.5
39crescentic glomerulonephritis9.5
40papillary carcinoma9.5
41peritonitis9.5
42al amyloidosis9.5
43ah amyloidosis9.5
44anaplastic ganglioglioma9.5APOA1, B2M, LPA, MEFV, SAA1, SAA2
45hard palate cancer8.3APOA1, APOA2, APP, B2M, FGA, GSN
46van maldergem syndrome 28.1APOA1, APOA2, APP, B2M, FGA, GSN

Graphical network of the top 20 diseases related to Amyloidosis, Familial Visceral:



Diseases related to amyloidosis, familial visceral

Symptoms & Phenotypes for Amyloidosis, Familial Visceral

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Symptoms by clinical synopsis from OMIM:

105200

Clinical features from OMIM:

105200

Human phenotypes related to Amyloidosis, Familial Visceral:

 64 (show all 11)
id Description HPO Frequency HPO Source Accession
1 proteinuria64 HP:0000093
2 nephrotic syndrome64 HP:0000100
3 nephropathy64 HP:0000112
4 hematuria64 HP:0000790
5 hypertension64 HP:0000822
6 edema64 HP:0000969
7 skin rash64 HP:0000988
8 cholestasis64 HP:0001396
9 splenomegaly64 HP:0001744
10 hepatomegaly64 HP:0002240
11 generalized amyloid deposition64 HP:0003216

MGI Mouse Phenotypes related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7APOA1, B2M, FGA, LYZ, MEFV, TNFRSF1A
2MP:00107717.7APOA1, APP, B2M, FGA, GSN, LYZ
3MP:00053977.6APP, B2M, FGA, GSN, IAPP, LYZ
4MP:00053877.5APP, B2M, FGA, GSN, IAPP, LYZ
5MP:00053766.4APOA1, APOA2, APP, B2M, FGA, GSN

Drugs & Therapeutics for Amyloidosis, Familial Visceral

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Drugs for Amyloidosis, Familial Visceral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Doxycyclineapproved, investigational, vet_approvedPhase 2243564-25-054671203
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
5-hydroxy-╬▒-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6alpha-deoxy-5-oxytetracycline
6╬▒-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Alti-Doxycycline
Anhydrous doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline (200mg/day) or Placebo
 
Doxycycline (INN)
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline
2
Tauroursodeoxycholic acidapproved, investigationalPhase 21314605-22-212443252
Synonyms:
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl) amino)ethanesulfonate
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl) amino)ethanesulfonic acid
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)-Ethanesulfonate
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)-Ethanesulfonic acid
3a,7b-Dihydroxy-5b-cholanoyltaurine
 
N-(3-alpha,7-beta-Dihydroxy-5-beta-cholan-24-oyl)-Taurine
TUDCA
Tauroursodeoxycholate
Tauroursodeoxycholic acid
Tauroursodesoxycholic acid
UR 906
Ursodeoxycholyltaurine
3Gastrointestinal AgentsPhase 28402
4Taurochenodeoxycholic AcidPhase 212
5Cholagogues and CholereticsPhase 2130
6Antiviral AgentsPhase 29967
7Anti-Infective AgentsPhase 222062
8AntimalarialsPhase 21246
9Antiparasitic AgentsPhase 22199
10Antiprotozoal AgentsPhase 22051
11Anti-Bacterial AgentsPhase 211226

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety, Efficacy and Pharmacokinetics of Doxycycline Plus Tauroursodeoxycholic Acid in Transthyretin AmyloidosisCompletedNCT01171859Phase 2

Search NIH Clinical Center for Amyloidosis, Familial Visceral

Genetic Tests for Amyloidosis, Familial Visceral

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Anatomical Context for Amyloidosis, Familial Visceral

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MalaCards organs/tissues related to Amyloidosis, Familial Visceral:

36
Skin, Kidney, Bone

Publications for Amyloidosis, Familial Visceral

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Variations for Amyloidosis, Familial Visceral

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UniProtKB/Swiss-Prot genetic disease variations for Amyloidosis, Familial Visceral:

70
id Symbol AA change Variation ID SNP ID
1APOA1p.Gly50ArgVAR_000609rs28931574
2APOA1p.Leu84ArgVAR_000610rs121912724
3B2Mp.Asp96AsnVAR_076691rs398122820
4FGAp.Glu545ValVAR_010731rs121909612
5FGAp.Arg573LeuVAR_010732rs78506343
6LYZp.Ile74ThrVAR_004280rs121913547
7LYZp.Asp85HisVAR_004281rs121913548

Clinvar genetic disease variations for Amyloidosis, Familial Visceral:

5 (show all 16)
id Gene Variation Type Significance SNP ID Assembly Location
1LYZNM_ 000239.2(LYZ): c.221T> C (p.Ile74Thr)SNVPathogenicrs121913547GRCh37Chr 12, 69743972: 69743972
2LYZNM_ 000239.2(LYZ): c.199G> C (p.Asp67His)SNVPathogenicrs387906535GRCh37Chr 12, 69743950: 69743950
3LYZNM_ 000239.2(LYZ): c.244T> C (p.Trp82Arg)SNVPathogenicrs387906536GRCh37Chr 12, 69743995: 69743995
4LYZNM_ 000239.2(LYZ): c.223T> A (p.Phe75Ile)SNVPathogenicrs121913549GRCh37Chr 12, 69743974: 69743974
5LYZNM_ 000239.2(LYZ): c.244T> A (p.Trp82Arg)SNVPathogenicrs387906536GRCh37Chr 12, 69743995: 69743995
6FGANM_ 000508.4(FGA): c.1718G> T (p.Arg573Leu)SNVPathogenicrs78506343GRCh37Chr 4, 155506863: 155506863
7FGANM_ 000508.4(FGA): c.1622delT (p.Val541Alafs)deletionPathogenicrs587777761GRCh38Chr 4, 154585807: 154585807
8FGANM_ 000508.4(FGA): c.1634A> T (p.Glu545Val)SNVPathogenicrs121909612GRCh37Chr 4, 155506947: 155506947
9FGANM_ 000508.4(FGA): c.1629delG (p.Thr544Leufs)deletionPathogenicrs587777762GRCh37Chr 4, 155506952: 155506952
10FGANM_ 000508.4(FGA): c.991A> G (p.Thr331Ala)SNVrisk factorrs6050GRCh37Chr 4, 155507590: 155507590
11APOA1NM_ 000039.2(APOA1): c.251T> G (p.Leu84Arg)SNVPathogenicrs121912724GRCh37Chr 11, 116707077: 116707077
12APOA1APOA1, 12-BP DEL AND 2-BP INSindelPathogenic
13APOA1NM_ 000039.2(APOA1): c.220T> C (p.Trp74Arg)SNVPathogenicrs121912726GRCh37Chr 11, 116707108: 116707108
14APOA1NM_ 000039.2(APOA1): c.593T> C (p.Leu198Ser)SNVPathogenicrs121912729GRCh37Chr 11, 116706735: 116706735
15APOA1NM_ 000039.2(APOA1): c.595G> C (p.Ala199Pro)SNVPathogenicrs121912730GRCh37Chr 11, 116706733: 116706733
16B2MNM_ 004048.2(B2M): c.286G> A (p.Asp96Asn)SNVPathogenicrs398122820GRCh37Chr 15, 45007839: 45007839

Expression for genes affiliated with Amyloidosis, Familial Visceral

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Search GEO for disease gene expression data for Amyloidosis, Familial Visceral.

Pathways for genes affiliated with Amyloidosis, Familial Visceral

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Pathways related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
110.0APOA1, APOA2
29.6APP, SAA1
3
Show member pathways
9.2APOA1, SAA1, SAA2, SAA4
48.6APP, PSEN1, TNFRSF1A
5
Show member pathways
7.5APOA1, APP, B2M, FGA, GSN, IAPP
6
Show member pathways
7.5APOA1, APP, B2M, FGA, GSN, IAPP
7
Show member pathways
6.6APP, B2M, FGA, GSN, LYZ, MEFV

GO Terms for genes affiliated with Amyloidosis, Familial Visceral

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Cellular components related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:004262710.8APOA1, APOA2
2endocytic vesicle lumenGO:007168210.7APOA1, SAA1
3spherical high-density lipoprotein particleGO:003436610.3APOA1, APOA2
4blood microparticleGO:007256210.1APOA1, APOA2, FGA, GSN
5very-low-density lipoprotein particleGO:003436110.0APOA1, APOA2
6ciliary rootletGO:00352539.9APP, PSEN1
7endoplasmic reticulum lumenGO:00057889.8APOA1, APOA2, APP, B2M, FGA
8high-density lipoprotein particleGO:00343649.3APOA1, APOA2, SAA1, SAA2, SAA4
9cell surfaceGO:00099868.7APOA1, APP, B2M, FGA, PSEN1, TNFRSF1A
10extracellular exosomeGO:00700627.7APOA1, APOA2, APP, B2M, FGA, GSN
11extracellular spaceGO:00056156.5APOA1, APOA2, APP, B2M, FGA, GSN
12extracellular regionGO:00055766.4APOA1, APOA2, APP, B2M, FGA, GSN

Biological processes related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cholesterol effluxGO:003334410.7APOA1, APOA2
2cholesterol transportGO:003030110.7APOA1, APOA2
3chylomicron assemblyGO:003437810.7APOA1, APOA2
4chylomicron remodelingGO:003437110.7APOA1, APOA2
5high-density lipoprotein particle assemblyGO:003438010.7APOA1, APOA2
6high-density lipoprotein particle clearanceGO:003438410.7APOA1, APOA2
7high-density lipoprotein particle remodelingGO:003437510.7APOA1, APOA2
8lipoprotein biosynthetic processGO:004215810.7APOA1, APOA2
9negative regulation of cytokine secretion involved in immune responseGO:000274010.7APOA1, APOA2
10negative regulation of lipase activityGO:006019210.7APOA1, APOA2
11negative regulation of very-low-density lipoprotein particle remodelingGO:001090310.7APOA1, APOA2
12peptidyl-methionine modificationGO:001820610.6APOA1, APOA2
13phospholipid effluxGO:003370010.6APOA1, APOA2
14positive regulation of cholesterol esterificationGO:001087310.6APOA1, APOA2
15protein oxidationGO:001815810.5APOA1, APOA2
16regulation of intestinal cholesterol absorptionGO:003030010.5APOA1, APOA2
17amyloid fibril formationGO:199000010.3APP, GSN
18low-density lipoprotein particle remodelingGO:003437410.3APOA2, LPA
19acute-phase responseGO:000695310.2SAA1, SAA2, SAA4
20cholesterol metabolic processGO:000820310.2APOA1, APOA2, APP
21platelet degranulationGO:000257610.2APOA1, APP, FGA
22positive chemotaxisGO:005091810.1SAA1, SAA2, SAA4
23lipid transportGO:000686910.1APOA1, APOA2, LPA
24lipoprotein metabolic processGO:004215710.1APOA1, APOA2, LPA
25retinoid metabolic processGO:000152310.0APOA1, APOA2, TTR
26astrocyte activation involved in immune responseGO:00022659.9APP, PSEN1
27cellular response to beta-amyloidGO:19046469.9APP, PSEN1
28reverse cholesterol transportGO:00436919.9APOA1, APOA2
29negative regulation of inflammatory responseGO:00507289.8APOA1, MEFV, SAA1, TNFRSF1A
30post-translational protein modificationGO:00436879.8APOA1, APOA2, APP, FGA
31regulation of epidermal growth factor-activated receptor activityGO:00071769.7APP, PSEN1
32regulation of protein bindingGO:00433939.6APP, PSEN1
33innate immune responseGO:00450879.6APP, B2M, FGA, MEFV, SAA1
34smooth endoplasmic reticulum calcium ion homeostasisGO:00515639.1APP, PSEN1
35neutrophil degranulationGO:00433129.1B2M, GSN, LYZ, PSEN1, TTR
36apoptotic processGO:00069158.5APP, GSN, IAPP, PSEN1, TNFRSF1A
37cellular protein metabolic processGO:00442677.2APOA1, APOA2, APP, B2M, FGA, GSN

Molecular functions related to Amyloidosis, Familial Visceral according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1apolipoprotein receptor bindingGO:003419010.7APOA1, APOA2
2cholesterol transporter activityGO:001712710.7APOA1, APOA2
3high-density lipoprotein particle bindingGO:000803510.7APOA1, APOA2
4high-density lipoprotein particle receptor bindingGO:007065310.7APOA1, APOA2
5lipase inhibitor activityGO:005510210.4APOA1, APOA2
6lipid transporter activityGO:000531910.4APOA1, APOA2
7chemoattractant activityGO:004205610.1SAA1, SAA2, SAA4
8phosphatidylcholine bindingGO:003121010.1APOA1, APOA2
9phosphatidylcholine-sterol O-acyltransferase activator activityGO:006022810.0APOA1, APOA2
10identical protein bindingGO:00428028.9APOA1, APP, B2M, IAPP, LYZ, TTR

Sources for Amyloidosis, Familial Visceral

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet