MCID: AMY053
MIFTS: 50

Amyloidosis, Secondary malady

Neuronal, Nephrological, Bone categories

Summaries for Amyloidosis, Secondary

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33MalaCards
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MalaCards: Amyloidosis, Secondary, also known as secondary amyloidosis, is related to amyloidosis and arthritis. An important gene associated with Amyloidosis, Secondary is APCS (amyloid P component, serum), and among its related pathways are Scavenging by Class B Receptors and Folate Metabolism. The compounds dimyristoylphosphatidylcholine and glucose have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and spinal cord, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Classifications for Amyloidosis, Secondary

Sources:
47OMIM, 45Novoseek, 49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Nephrological, Bone


Characteristics (Orphanet epidemiological data):

49
secondary amyloidosis:
Prevalence: 1-5/10000


Aliases & Descriptions:

amyloidosis, secondary 47
secondary amyloidosis 49 61
inflammatory amyloidosis 49
amyloidosis secondary 45
reactive amyloidosis 49
amyloidosis aa 49


External Ids:

ICD10 via Orphanet26 E85.3
SNOMED-CT via Orphanet58 274945004, 281034005
UMLS via Orphanet62 C0221014

Related Diseases for Amyloidosis, Secondary

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Amyloidosis, Secondary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis36.3SAA1, APOA1, APCS, CTSB, LPA, CRP
2arthritis35.7SAA4, SAA1, TNF, CTSB, CRP, MEFV
3amyloidosis, renal35.6SAA2, SAA4, SAA1, APOA1, MEFV, TTR
4rheumatic disease35.4TNF, CRP, MEFV
5familial mediterranean fever35.1TNF, MEFV
6amyloid neuropathy35.1TTR, APOA1
7hepatitis c34.9CTSB, ALB
8amyloid tumor34.9SAA2, SAA4, CTSB, B2M, LTF, TTR
9alzheimer's disease34.9SAA4, APCS, CTSB, LPA, TTR
10behcet's disease34.9MEFV, CRP, TNF
11vasculitis34.9ALB, LTF, MEFV, CRP, TNF
12hereditary amyloidosis34.9APOA1, TTR
13muckle-wells syndrome34.9MEFV
14crohn's disease30.5ALB, LTF, CRP, TNF
15reactive arthritis30.2LTF, CRP
16ankylosing spondylitis30.1TNF, CRP
17cystic fibrosis30.1ALB, LTF
18ulcerative colitis30.1ALB, LTF, CRP, TNF
19systemic lupus erythematosus29.9CRP
20psoriatic arthritis29.9CRP, TNF
21peripheral vascular disease13.3APOA1, LPA, ALB
22deficiency anemia13.3LCAT, SAA1, CRP, B2M, TTR, ALB
23stroke, ischemic13.3APOA1, LPA, CRP, ALB
24diabetic nephropathy13.3ALB, B2M, LPA, APOA1
25coronary artery disease,13.3LCAT, SAA4, SAA1, APOA1, LPA, CRP
26gout13.3LCAT
27acute pancreatitis13.3CRP, CTSB
28tangier disease13.3LPA, APOA1, LCAT
29abetalipoproteinemia13.3LCAT, APOA1
30hypobetalipoproteinemia13.3APOA1, LCAT
31norum disease13.3LCAT, APOA1
32alcohol abuse13.3LCAT
33obstructive jaundice13.3LCAT, TTR
34arcus senilis13.3LCAT, APOA1
35erysipelas13.3MEFV
36blau syndrome13.3TNF, MEFV
37palindromic rheumatism13.3MEFV
38osteoarthritis13.3SAA1, TNF, CTSB, CRP
39polyarteritis nodosa13.3MEFV, LTF
40polycystic ovary syndrome13.3APOA1, CRP
41hyperhomocysteinemia13.3LPA, CRP, TTR, ALB
42alagille syndrome13.3LPA, APOA1, LCAT
43acromegaly13.3LPA
44hepatitis b13.3APOA1, CTSB, LTF, ALB
45alcoholic hepatitis13.3TNF, APOA1, ALB
46familial hypercholesterolemia13.3LCAT, APOA1, LPA
47acute myocardial infarction13.3LCAT, SAA4, SAA1, APOA1, LPA, CRP
48arteriosclerosis13.3APOA1
49atherosclerosis13.3LCAT, SAA4, SAA1, TNF, APOA1, LPA
50breast cancer13.3LCAT, CTSB, ALB

Graphical network of the top 20 diseases related to Amyloidosis, Secondary:



Diseases related to amyloidosis, secondary

Clinical Features for Amyloidosis, Secondary

Drugs & Therapeutics for Amyloidosis, Secondary

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Amyloidosis, Secondary

Drug clinical trials:

Search ClinicalTrials for Amyloidosis, Secondary

Search NIH Clinical Center for Amyloidosis, Secondary

Search CenterWatch for Amyloidosis, Secondary

Genetic Tests for Amyloidosis, Secondary

Anatomical Context for Amyloidosis, Secondary

Sources:
33MalaCards
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MalaCards organs/tissues related to Amyloidosis, Secondary:

33
Bone marrow, Spleen, Spinal cord, Heart, Skeletal muscle, Colon, Kidney, Liver, Lung, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Testis, Myeloid, Endothelial

Animal Models for Amyloidosis, Secondary or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Amyloidosis, Secondary:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5LTF, B2M, APCS, TNF
2MP:00053708.0ALB, LTF, B2M, TNF
3MP:00053877.7B2M, CRP, APCS, TNF, LTF
4MP:00053766.7TTR, ALB, B2M, CRP, TNF, SAA1

Publications for Amyloidosis, Secondary

Sources:
51PubMed
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Articles related to Amyloidosis, Secondary:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Chronic renal failure secondary to systemic amyloidosis associated with gastrointestinal stromal tumour. (23897208)
2013
2
The permanent improvement of proteinuria and renal failure with colchicine and enalapril in a leukemic patient with renal amyloidosis secondary to ankylosing spondylitis: a review of the literature. (22975660)
2013
3
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
4
Successful use of maintenance infliximab for nephropathy in a patient with secondary amyloidosis complicating Crohn's disease. (23994979)
2013
5
A case of psoriasis with secondary amyloidosis, associated symbrachydactyly of the hand and a transverse deficiency of the foot. (22953651)
2012
6
Probing the use of fluorescence spectroscopy as a novel diagnostic tool in patients with rheumatoid arthritis: applicability in the detection of secondary amyloidosis. (23018349)
2012
7
BehAset's disease associated with diarrhea and secondary amyloidosis. (21480125)
2011
8
Chyloperitoneum: is secondary amyloidosis a possible cause? (19776056)
2009
9
Secondary amyloidosis of the conjunctiva and mucosa of upper respiratory tract associated with renal cell carcinoma: case report and review of literature. (19630323)
2009
10
Secondary amyloidosis manifesting as bilateral blepharoedema. (19734988)
2009
11
Secondary amyloidosis associated with histiocytosis X. (18266125)
2008
12
Recurrent subconjunctival and periorbital haemorrhage as the first presentation of systemic AL amyloidosis secondary to myeloma. (15905867)
2006
13
Rapidly progressed secondary amyloidosis in a patient with mixed connective tissue disease. (15497530)
2004
14
Addison's disease associated with widespread abdomino-pelvic visceral calcification due to secondary amyloidosis: a case report. (15690607)
2004
15
Multicentric Castleman's disease complicated by secondary renal amyloidosis. (15663642)
2004
16
Anti-TNF treatment in secondary amyloidosis. (14578444)
2003
17
Secondary amyloidosis in Castleman's disease: review of the literature and report of a case. (12107565)
2002
18
Secondary amyloidosis in chronic rheumatic diseases. (11225132)
2001
19
A case of secondary amyloidosis with calcium deposition in the liver. (11317038)
2001
20
Fine needle aspiration biopsy for the diagnosis of secondary amyloidosis. (10934971)
2000
21
Progressive multifocal leukoencephalopathy in a 15-year-old boy with scleroderma and secondary amyloidosis. (9832587)
1998
22
Gastrointestinal amyloidosis secondary to hypersensitivity vasculitis presenting with intestinal pseudoobstruction. (9724175)
1998
23
Secondary amyloidosis following juvenile chronic arthritis. (8772932)
1996
24
Increased circulating serum amyloid A protein derivatives in rheumatoid arthritis patients with secondary amyloidosis. (8804360)
1996
25
Secondary amyloidosis complicating arthropathic psoriasis. (8759204)
1996
26
Secondary amyloidosis complicating psoriasis. (7868717)
1995
27
Amyloidosis secondary to xanthogranulomatous pyelonephritis: an unusual case. (7646703)
1995
28
Case report: acute renal vein thrombosis in patients with spinal cord injury and secondary amyloidosis. (8042653)
1994
29
Splenic macrophage activation and functions in amyloid enhancing factor-induced secondary amyloidosis. Study of phagocytosis, killing, respiratory burst, and MHC class II surface expression. (8391054)
1993
30
Achalasia of the esophagus in secondary amyloidosis. (8237950)
1993
31
Generalized secondary amyloidosis in rheumatoid arthritis. (1365773)
1992
32
Radiology of secondary amyloidosis of the stomach in a patient with rheumatoid arthritis. (1873663)
1991
33
Esophageal involvement in secondary amyloidosis mimicking achalasia. (2398252)
1990
34
A highly sensitive method for diagnosis of secondary amyloidosis by labial salivary gland biopsy. (2769600)
1989
35
Hypocholesterolaemia in cases of nephrotic syndrome with secondary amyloidosis. (3171202)
1988
36
Secondary amyloidosis of the bladder: a cause of massive hematuria. (3599217)
1987
37
Tuberculosis as a continuing cause of secondary amyloidosis in northern India. (3448136)
1987
38
Favorable effect of dimethyl sulfoxide on secondary amyloidosis in juvenile rheumatoid arthritis. (6493840)
1984
39
Secondary amyloidosis and sicca syndrome. (7417359)
1980
40
Demonstration of amyloid in murine and human secondary amyloidosis by the immunoperoxidase technique. (7003080)
1980
41
Secondary amyloidosis developing after pancreaticoduodenal resection. (869480)
1977
42
Secondary localized cutaneous amyloidosis associated with actinic keratosis. (4749463)
1973
43
Catastrophic haemorrhage from the bladder due to unrecognised secondary amyloidosis. (5435701)
1970
44
Congestive cardiac failure due to secondary amyloidosis. (5768351)
1969
45
Diagnosis of secondary amyloidosis. (5674373)
1968
46
Blastomycosis with secondary amyloidosis in the dog. (6067612)
1967
47
Secondary amyloidosis in leprosy. (5950066)
1966
48
"Specific" diseases simulating "nonspecific" ulcerative colitis (lymphopathia venereum, acute vasculitis, scleroderma and secondary amyloidosis. (13470718)
1957
49
Secondary amyloidosis. (18134812)
1949
50
Secondary amyloidosis; a brief review of the literature. (18862453)
1947

Genetic Variations for Amyloidosis, Secondary

Expression for genes affiliated with Amyloidosis, Secondary

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Amyloidosis, Secondary

Search GEO for disease gene expression data for Amyloidosis, Secondary.

Pathways for genes affiliated with Amyloidosis, Secondary

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Pathways related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1SAA1
210.1SAA1
3
Hide members
9.7ALB
49.3ALB, SAA1
59.2TTR, ALB
69.1CRP, ALB
7
Hide members
8.3SAA1, APCS, B2M, LTF, TTR
88.3SAA1, APCS, B2M, LTF, TTR
98.2ALB, SAA1, TNF, CRP

Compounds for genes affiliated with Amyloidosis, Secondary

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1dimyristoylphosphatidylcholine4510.7
2glucose4510.5SAA1
3alpha tocopherol4510.5TTR
4pdpc4510.5
5retinyl palmitate45 2411.4TTR
6bezafibrate45 29 1112.3CRP
7vitamin a45 11 2412.3LTF
8pravastatin45 50 29 11 2414.2CRP
9probucol45 1111.1LTF
10uric acid45 2411.1TTR, B2M
11nh4cl459.9B2M
12dexamethasone45 50 29 1112.9SAA1, LTF
13tenidap45 2910.9LTF, SAA1
14endotoxin459.9SAA1, LTF
15polyacrylamide459.8TTR, LTF
16estrogen459.8LTF, TTR
17atorvastatin45 50 29 11 2413.8TNF, CRP
18fenofibrate45 50 1111.8TNF, CRP
19pentosidine459.5ALB, B2M
20sodium dodecylsulfate459.5TTR, ALB
21simvastatin45 50 60 29 11 2414.5SAA1, CRP, TNF
22idpn459.3ALB, TTR
23iron45 2410.3LTF, TTR, B2M
24hydrochlorothiazide45 50 29 11 2413.3ALB, CRP
25thyroxine45 2410.2B2M, TTR, ALB
26urea45 11 2411.2ALB, TTR, B2M
27homocysteine45 2410.2ALB, TTR, CRP
28pmma459.1CRP, LTF, B2M
29vitamin b6459.1ALB, TTR, CRP
30gamma globulin459.0ALB, CRP, B2M
31iohexol459.0ALB, LTF, B2M
32polysulfone458.8ALB, B2M, CRP
33glutamine458.8LTF, CRP, TTR, B2M
3425-hydroxyvitamin d458.7B2M, ALB, TTR, CRP
35folate458.6TTR, B2M, ALB, CRP
36aspartate458.6LTF, TTR, ALB, B2M
37cellulose acetate458.5ALB, TTR, B2M
38ascorbic acid45 249.5ALB, TTR, LTF, CRP
39testosterone45 60 11 2411.4ALB, TTR, B2M, CRP
40indomethacin45 60 29 1111.4ALB, LTF, B2M, TNF
41cysteine458.4LTF, ALB, TTR, B2M
42neopterin458.4TTR, LTF, B2M, CRP, TNF
43cholesterol45 29 11 2411.3SAA1, ALB, TTR, CRP, B2M
44lipid458.3ALB, CRP, SAA1, APCS, TNF
45hyaluronic acid45 249.2LTF, TTR, ALB, B2M
46lactate458.1ALB, TTR, B2M, CRP, TNF
47vitamin b12458.1ALB, TTR, LTF, B2M, CRP
48creatinine458.1TTR, CRP, ALB, B2M, LTF
49alanine457.7CRP, B2M, ALB, LTF, TTR, SAA1
50fibrinogen457.7TTR, CRP, LTF, TNF, SAA1, ALB

GO Terms for genes affiliated with Amyloidosis, Secondary

Sources:
16Gene Ontology
See all sources

Cellular components related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.1SAA1
2high-density lipoprotein particleGO:03436410.0SAA1
3extracellular spaceGO:0056157.1TNF, APCS, CRP, B2M, TTR, ALB
4extracellular regionGO:0055766.4ALB, SAA1, TNF, APCS, CRP, B2M

Biological processes related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.6
2lipoprotein biosynthetic processGO:04215810.5
3reverse cholesterol transportGO:04369110.5
4high-density lipoprotein particle remodelingGO:03437510.4
5negative regulation of inflammatory responseGO:05072810.3SAA1
6cholesterol transportGO:03030110.2
7lipoprotein metabolic processGO:0421579.8ALB
8acute-phase responseGO:0069539.4CRP, APCS, SAA1
9negative regulation of lipid storageGO:0108889.4CRP, TNF

Products for genes affiliated with Amyloidosis, Secondary

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amyloidosis, Secondary

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet