MCID: AMY053
MIFTS: 52

Amyloidosis, Secondary malady

Neuronal diseases, Nephrological diseases, Bone diseases, Rare diseases categories
Download this MalaCard

Summaries for Amyloidosis, Secondary

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Amyloidosis, Secondary, also known as secondary amyloidosis, is related to amyloidosis and arthritis. An important gene associated with Amyloidosis, Secondary is APCS (amyloid P component, serum), and among its related pathways are Statin Pathway and Selected targets of C EBPalpha. The compounds pmma and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Amyloidosis, Secondary

About this section
Sources:
49Orphanet, 47OMIM, 45Novoseek, 62UMLS, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

49
secondary amyloidosis:
Prevalence: 1-5/10000


Aliases & Descriptions:

amyloidosis, secondary 47
secondary amyloidosis 49 62
inflammatory amyloidosis 49
amyloidosis secondary 45
reactive amyloidosis 49
amyloidosis aa 49


External Ids:

ICD10 via Orphanet26 E85.3
SNOMED-CT via Orphanet59 274945004, 281034005
UMLS via Orphanet63 C0221014

Related Diseases for Amyloidosis, Secondary

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Amyloidosis, Secondary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 216)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis30.9SAA4, APOA1, APCS, TTR, B2M, SAA2
2arthritis30.8CTSB, TNF
3pyelonephritis30.6B2M, CRP
4rheumatoid arthritis30.3LPA, SAA1, SAA2, SAA4, APOA1, TNF
5rheumatic disease30.3TNF, MEFV, CRP
6familial mediterranean fever30.2TNF, MEFV
7diarrhea30.2TTR, ALB, CRP, LTF
8juvenile rheumatoid arthritis30.2TNF, CRP
9muckle-wells syndrome30.1MEFV
10ankylosing spondylitis30.1CRP, TNF
11ulcerative colitis30.1TNF, CRP, LTF
12proteinuria30.1B2M, TTR, APOA1, SAA4, LPA, LCAT
13nephrotic syndrome30.1B2M, APOA1, LPA, LCAT, ALB
14crohn's disease30.1TNF, ALB, CRP, LTF
15autonomic neuropathy30.0ALB, TTR
16behcet's disease30.0TNF, MEFV, CRP
17glomerulonephritis30.0ALB, LPA, B2M
18periodontal disease30.0LTF, CRP, TNF
19psoriatic arthritis30.0TNF, CRP
20periodontitis30.0TNF, CTSB, LTF
21hypertension29.9APOA1, LPA, ALB, CRP
22malaria29.9TNF, ALB
23alzheimer's disease29.9TTR, APCS, SAA4, LPA, CTSB
24inflammatory bowel disease29.9TNF, CRP, LTF
25vasculitis29.8TNF, MEFV, ALB, CRP, LTF
26obesity29.8TNF, APOA1, SAA4, LPA, LCAT, CRP
27amyloidosis aa10.6
28tuberculosis10.4
29leprosy10.4
30psoriasis10.3
31xanthogranulomatous pyelonephritis10.3
32multiple myeloma10.2
33myeloma10.2
34osteomyelitis10.2
35eye disease10.1CRP
36epidural abscess10.1CRP
37septic arthritis10.1CRP
38adult-onset still's disease10.1CRP
39chronic pyelonephritis10.1B2M
40cystic fibrosis10.1
41achalasia10.1
42gastritis10.1
43lupus erythematosus10.1
44scleroderma10.1
45spondylitis10.1
46al amyloidosis10.1
47spinal cord injury10.1
48erysipelas10.1MEFV
49palindromic rheumatism10.1MEFV
50bacteriuria10.1CRP

Graphical network of the top 20 diseases related to Amyloidosis, Secondary:



Diseases related to amyloidosis, secondary

Symptoms for Amyloidosis, Secondary

About this section

Drugs & Therapeutics for Amyloidosis, Secondary

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Amyloidosis, Secondary

Search NIH Clinical Center for Amyloidosis, Secondary

Genetic Tests for Amyloidosis, Secondary

About this section

Anatomical Context for Amyloidosis, Secondary

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Amyloidosis, Secondary:

33
Bone, Thyroid

Animal Models for Amyloidosis, Secondary or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Amyloidosis, Secondary:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.6TNF, APCS, APOA1, MEFV, LCAT, LTF
2MP:00053877.2B2M, TNF, APCS, APOA1, MEFV, CRP
3MP:00053707.2B2M, TNF, APOA1, MEFV, LCAT, ALB
4MP:00053797.2B2M, TNF, APOA1, LCAT, ALB, CTSB
5MP:00053766.1LTF, B2M, TNF, TTR, APOA1, SAA1

Publications for Amyloidosis, Secondary

About this section
Sources:
52PubMed
See all sources

Articles related to Amyloidosis, Secondary:

(show all 34)
idTitleAuthorsYear
1
Sudden death possibly related to lenalidomide given for cardiac and muscle AL amyloidosis secondary to light chain deposition disease. (22504167)
2013
2
The permanent improvement of proteinuria and renal failure with colchicine and enalapril in a leukemic patient with renal amyloidosis secondary to ankylosing spondylitis: a review of the literature. (22975660)
2013
3
Renal amyloidosis secondary to rheumatoid arthritis: remission of proteinuria and renal function improvement with tocilizumab. (23669800)
2013
4
Renal and thyroid amyloidosis secondary tocryopyrin-associated periodic syndrome(Muckle-Wells syndrome) (NLRP3 mutation). (23511763)
2013
5
Cardiac amyloidosis secondary to multiple myeloma. (23882988)
2013
6
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
7
When first line therapy for AA-amyloidosis secondary to rheumatoid arthritis fails: a correspondence. (23022420)
2013
8
Amyloid goiter associated with amyloidosis secondary to rheumatoid arthritis. (24368922)
2013
9
Treatment with adalimumab in amyloidosis secondary to rheumatoid arthritis: two case reports. (23364579)
2013
10
The Effect of Etanercept on a Case of Amyloidosis Secondary to Ankylosing Spondylitis: Results of 2-Year Follow-Up. (24435036)
2013
11
Remission of proteinuria and preservation of renal function in patients with renal AA amyloidosis secondary to rheumatoid arthritis. (21771754)
2012
12
Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatments. (22011672)
2011
13
Pressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin: Transthyretin Cardiac Amyloid Study (TRACS). (21191093)
2011
14
Amyloidosis secondary to xanthogranulomatous pyelonephritis: a rare association. (20587879)
2010
15
Anakinra efficacy in a Caucasian patient with renal AA amyloidosis secondary to cryopyrin-associated periodic syndrome. (20609610)
2010
16
A hepatitis C-positive patient with new onset of nephrotic syndrome and systemic amyloidosis secondary to common variable immunodeficiency. (20697163)
2010
17
Renal AA amyloidosis secondary to morbid obesity? (19825338)
2009
18
Clinical strategies for amyloid A amyloidosis secondary to rheumatoid arthritis. (18369528)
2008
19
Amyloidosis secondary to hidradenitis suppurativa. Exceptional response to infliximab. (18848164)
2008
20
Recurrent subconjunctival and periorbital haemorrhage as the first presentation of systemic AL amyloidosis secondary to myeloma. (15905867)
2006
21
Significance of SAA1.3 allele genotype in Japanese patients with amyloidosis secondary to rheumatoid arthritis. (16219644)
2006
22
Resolution of acquired factor X deficiency with amyloidosis secondary to plasma cell dyscrasia. (15551292)
2004
23
Gustatory sweating due to autonomic neuropathy in a patient with amyloidosis secondary to rheumatoid arthritis. (24387731)
2004
24
A case of corneal lactoferrin amyloidosis secondary to trichiasis]. (12647336)
2003
25
Anti-tumor necrosis factor alpha therapy in fifteen patients with AA amyloidosis secondary to inflammatory arthritides: a followup report of tolerability and efficacy. (12847696)
2003
26
Efficacy of cyclophosphamide combined with prednisolone in patients with AA amyloidosis secondary to rheumatoid arthritis. (14677008)
2003
27
A novel single-nucleotide polymorphism at the 5'-flanking region of SAA1 associated with risk of type AA amyloidosis secondary to rheumatoid arthritis. (11407685)
2001
28
Spontaneous regression of bilateral surrenal haematoma and subclinical hypoaldosteronism in a patient with renal amyloidosis secondary to Familial Mediterranean Fever. (11229653)
2000
29
Gastrointestinal amyloidosis secondary to hypersensitivity vasculitis presenting with intestinal pseudoobstruction. (9724175)
1998
30
Chronic nephrotic syndrome and chronic renal failure by amyloidosis secondary to xanthogranulomatous pyelonephritis. (9491290)
1998
31
Pellagra associated with amyloidosis secondary to multiple myeloma. (9415256)
1997
32
A histopathological study of corneal amyloidosis secondary to trichiasis]. (8651059)
1996
33
Amyloidosis secondary to xanthogranulomatous pyelonephritis: an unusual case. (7646703)
1995
34
Generalized amyloidosis secondary to xanthogranulomatous pyelonephritis. (3816863)
1986

Variations for Amyloidosis, Secondary

About this section

Expression for genes affiliated with Amyloidosis, Secondary

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Amyloidosis, Secondary

Search GEO for disease gene expression data for Amyloidosis, Secondary.

Pathways for genes affiliated with Amyloidosis, Secondary

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 12EMD Millipore, 30KEGG, 55Reactome, 53QIAGEN
See all sources

Pathways related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5LCAT, APOA1
29.5LTF, ALB
39.1APOA1, TNF
4
Show member pathways
9.1APOA1, SAA1, ALB
59.1ALB, APOA1, TTR
6
Show member pathways
9.0B2M, TNF, CTSB
7
Show member pathways
Vitamin B12 Metabolism38
8.9APOA1, SAA4, SAA2, SAA1
88.6B2M, TTR, APCS, APOA1, SAA1, LTF
98.6CRP, ALB, LPA, APOA1
10
Show member pathways
8.5APOA1, LPA, LCAT, ALB
11
Show member pathways
7.8B2M, TNF, TTR, APCS, APOA1, SAA1
12
Show member pathways
thioredoxin pathway38
7.2CRP, TNF, APOA1, SAA4, SAA2, SAA1

Compounds for genes affiliated with Amyloidosis, Secondary

About this section
Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience
See all sources

Compounds related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1pmma459.8LTF, B2M, CRP
2gamma globulin459.6CRP, ALB, B2M
3pentosidine459.6ALB, CRP, B2M
4retinyl palmitate45 2410.6LCAT, APOA1, TTR
5nh4cl459.5CRP, B2M, CTSB
6probucol45 1110.3LCAT, LTF, APOA1
7dimyristoylphosphatidylcholine459.3LPA, APOA1, LCAT
8polysulfone459.3CRP, ALB, B2M
9vitamin b6459.3ALB, CRP, TTR, CTSB
10tenidap45 2910.2LTF, CRP, TNF, SAA1
11bezafibrate45 29 1111.2APOA1, LCAT, LPA, CRP
12rituximab45 51 1111.2CRP, SAA1, TNF, B2M
13iohexol459.1LTF, APOA1, B2M, ALB
14pravastatin45 51 29 24 1113.1LPA, LCAT, CRP, APOA1
1525-hydroxyvitamin d459.0TTR, APOA1, ALB, B2M, CRP
16folate458.9CRP, ALB, LPA, TTR, B2M
17sodium dodecylsulfate458.9TTR, ALB, LCAT, LPA
18glutamine458.9TTR, LCAT, B2M, CRP, CTSB, LTF
19urea45 24 1110.9CTSB, LPA, TTR, B2M, ALB
20hydrochlorothiazide45 29 51 24 1112.8ALB, CRP, APOA1
21fenofibrate45 51 1110.7TNF, APOA1, CRP, LPA
22iron45 249.7B2M, ALB, CRP, CTSB, TTR, LTF
23polyacrylamide458.5TTR, LTF, CTSB, LCAT, LPA, SAA4
24ascorbic acid45 249.4ALB, LTF, APOA1, TTR, CRP, LCAT
25cyclosporin a45 29 6110.4CTSB, TTR, TNF, B2M, LTF
26rosiglitazone29 45 51 24 1112.4LPA, ALB, CRP, TNF
27thyroxine45 249.4TTR, APOA1, ALB, CTSB, LPA, B2M
28testosterone45 61 24 1111.4B2M, TTR, CRP, ALB, LCAT, APOA1
29atorvastatin45 51 29 24 1112.4APOA1, LCAT, CRP, LPA, TNF
30endotoxin458.3LTF, TNF, SAA4, CRP, SAA1, MEFV
31alpha tocopherol458.3APOA1, SAA4, LCAT, CRP, TTR, ALB
32homocysteine45 249.2APOA1, SAA4, LPA, ALB, CRP, TTR
33aspartate458.2CTSB, CRP, ALB, APOA1, B2M, TTR
34vitamin b12458.2LTF, TTR, CRP, ALB, LPA, APOA1
35simvastatin45 51 61 29 24 1113.2SAA1, CRP, LPA, TNF, APOA1, LCAT
36neopterin458.1B2M, CTSB, CRP, LTF, TNF, TTR
37cysteine458.0LCAT, TTR, LTF, ALB, CTSB, LPA
38vegf458.0LPA, B2M, CRP, CTSB, TNF, LTF
39uric acid45 249.0TTR, B2M, LPA, SAA4, ALB, APOA1
40estrogen458.0LCAT, B2M, TTR, APOA1, SAA1, LPA
41indomethacin45 29 61 1110.9B2M, TNF, APOA1, ALB, CTSB, LTF
42vitamin a45 24 119.8B2M, TTR, APOA1, LPA, ALB, CRP
43lactate457.7B2M, TNF, TTR, APOA1, ALB, CTSB
44alanine457.6ALB, B2M, LTF, TTR, APOA1, LCAT
45glucose457.3TTR, APOA1, B2M, SAA4, SAA1, CRP
46creatinine457.3B2M, TTR, APOA1, SAA4, LPA, CTSB
47dexamethasone45 51 29 1110.1CTSB, LTF, LCAT, SAA1, TTR, SAA2
48cholesterol45 29 24 1110.0TTR, LPA, CTSB, B2M, CRP, ALB
49lipid456.8CRP, ALB, LCAT, SAA1, SAA4, APOA1
50fibrinogen456.5TTR, TNF, LTF, CTSB, CRP, ALB

GO Terms for genes affiliated with Amyloidosis, Secondary

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.7SAA1, APOA1
2blood microparticleGO:0725628.8ALB, APOA1, APCS
3high-density lipoprotein particleGO:0343648.5APOA1, SAA4, SAA2, SAA1, LCAT
4extracellular vesicular exosomeGO:0700627.8B2M, APCS, APOA1, SAA1, ALB, CTSB
5extracellular spaceGO:0056156.3B2M, TNF, TTR, APCS, APOA1, LCAT
6extracellular regionGO:0055765.2LTF, B2M, TNF, TTR, APCS, APOA1

Biological processes related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:0421589.8LCAT, APOA1
2cholesterol transportGO:0303019.7LCAT, APOA1
3high-density lipoprotein particle remodelingGO:0343759.7LCAT, APOA1
4reverse cholesterol transportGO:0436919.7APOA1, LCAT
5negative regulation of inflammatory responseGO:0507289.6MEFV, SAA1, APOA1
6phosphatidylcholine biosynthetic processGO:0066569.6LCAT, APOA1
7negative regulation of lipid storageGO:0108889.6TNF, CRP
8retina homeostasisGO:0018959.5B2M, ALB, LTF
9positive regulation of cytokine secretionGO:0507159.4TNF, SAA1
10negative regulation of cytokine secretion involved in immune responseGO:0027409.4APOA1, TNF
11defense response to Gram-positive bacteriumGO:0508309.4CRP, TNF
12acute-phase responseGO:0069539.2CRP, SAA1, SAA2, SAA4, APCS
13platelet activationGO:0301689.0ALB, SAA1, APOA1
14innate immune responseGO:0450879.0B2M, SAA1, MEFV, CTSB
15lipoprotein metabolic processGO:0421578.7APOA1, LPA, LCAT, ALB

Molecular functions related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.7CRP, APOA1
2identical protein bindingGO:0428028.5APOA1, TTR, TNF, B2M
3protein bindingGO:0055156.3B2M, TNF, TTR, APOA1, LCAT, ALB

Products for genes affiliated with Amyloidosis, Secondary

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amyloidosis, Secondary

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet