MCID: AMY053
MIFTS: 52

Amyloidosis, Secondary malady

Neuronal diseases, Nephrological diseases, Bone diseases, Rare diseases categories
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Summaries for Amyloidosis, Secondary

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MalaCards based summary: Amyloidosis, Secondary, also known as secondary amyloidosis, is related to pyelonephritis and arthritis. An important gene associated with Amyloidosis, Secondary is APCS (amyloid P component, serum), and among its related pathways are Statin Pathway and Selected targets of C EBPalpha. The compounds pmma and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Amyloidosis, Secondary

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Sources:
46OMIM, 44Novoseek, 48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Amyloidosis, Secondary, Aliases & Descriptions:

Name: Amyloidosis, Secondary 46
Secondary Amyloidosis 48 62
Inflammatory Amyloidosis 48
 
Amyloidosis Secondary 44
Reactive Amyloidosis 48
Amyloidosis Aa 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
secondary amyloidosis:
Prevalence: 1-5/10000


External Ids:

ICD10 via Orphanet26 E85.3
UMLS via Orphanet63 C0221014

Related Diseases for Amyloidosis, Secondary

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Diseases related to Amyloidosis, Secondary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis31.1B2M, CRP
2arthritis30.9CTSB, TNF
3muckle-wells syndrome30.7MEFV
4transthyretin amyloidosis30.5APOA1, TTR
5familial mediterranean fever30.5MEFV, TNF
6rheumatic disease30.4CRP, MEFV, TNF
7autonomic neuropathy30.3TTR, ALB
8crohn's disease30.3ALB, TNF, LTF, CRP
9diarrhea30.3LTF, TTR, ALB, CRP
10juvenile rheumatoid arthritis30.2CRP, TNF
11ulcerative colitis30.1CRP, LTF, TNF
12behcet's disease30.1TNF, CRP, MEFV
13glomerulonephritis30.1ALB, LPA, B2M
14periodontal disease30.1CRP, TNF, LTF
15psoriatic arthritis30.0TNF, CRP
16ankylosing spondylitis30.0CRP, TNF
17periodontitis30.0LTF, CTSB, TNF
18hypertension29.8APOA1, ALB, CRP, LPA
19nephrotic syndrome29.8ALB, LPA, LCAT, APOA1, B2M
20inflammatory bowel disease29.7TNF, CRP, LTF
21alzheimer's disease29.7APCS, CTSB, LPA, SAA4, TTR
22malaria29.7TNF, ALB
23amyloidosis29.5SAA4, APOA1, APCS, TTR, B2M, SAA2
24vasculitis29.5MEFV, TNF, ALB, CRP, LTF
25proteinuria29.4B2M, APOA1, CRP, SAA4, LPA, TTR
26obesity29.2TNF, LPA, APOA1, SAA4, LCAT, CRP
27rheumatoid arthritis29.1SAA4, LPA, MEFV, CRP, CTSB, B2M
28spiradenoma10.6CRP
29epidural abscess10.6CRP
30septic arthritis10.5CRP
31adult-onset still's disease10.5CRP
32chronic pyelonephritis10.5B2M
33palindromic rheumatism10.5MEFV
34erysipelas10.5MEFV
35rheumatoid vasculitis10.5LTF
36bacteriuria10.5CRP
37carpal tunnel syndrome10.4B2M, TTR
38oral candidiasis10.4LTF, B2M
39viral meningitis10.4B2M, CRP
40tuberculosis10.4
41acute pancreatitis10.4CTSB, CRP
42polyarteritis nodosa10.4MEFV, LTF
43brucellosis10.4SAA1, MEFV
44leprosy10.4
45obstructive jaundice10.4LCAT, TTR
46hepatorenal syndrome10.4ALB
47peripheral vascular disease10.4ALB
48iron metabolism disease10.4TTR, CRP
49reactive arthritis10.4LTF, CRP
50amyloid neuropathy10.3APOA1, TTR

Graphical network of the top 20 diseases related to Amyloidosis, Secondary:



Diseases related to amyloidosis, secondary

Symptoms for Amyloidosis, Secondary

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Drugs & Therapeutics for Amyloidosis, Secondary

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Drug clinical trials:

Search ClinicalTrials for Amyloidosis, Secondary

Search NIH Clinical Center for Amyloidosis, Secondary

Genetic Tests for Amyloidosis, Secondary

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Anatomical Context for Amyloidosis, Secondary

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MalaCards organs/tissues related to Amyloidosis, Secondary:

32
Bone, Thyroid

Animal Models for Amyloidosis, Secondary or affiliated genes

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MGI Mouse Phenotypes related to Amyloidosis, Secondary:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.6B2M, APCS, APOA1, MEFV, LCAT, LTF
2MP:00053877.2B2M, TNF, APCS, APOA1, MEFV, CRP
3MP:00053707.2LTF, B2M, ALB, LCAT, MEFV, APOA1
4MP:00053797.2ALB, LCAT, APOA1, TNF, B2M, CTSB
5MP:00053766.1LCAT, SAA1, ALB, CRP, CTSB, LTF

Publications for Amyloidosis, Secondary

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Articles related to Amyloidosis, Secondary:

(show all 35)
idTitleAuthorsYear
1
Sudden death possibly related to lenalidomide given for cardiac and muscle AL amyloidosis secondary to light chain deposition disease. (22504167)
2013
2
The permanent improvement of proteinuria and renal failure with colchicine and enalapril in a leukemic patient with renal amyloidosis secondary to ankylosing spondylitis: a review of the literature. (22975660)
2013
3
Renal amyloidosis secondary to rheumatoid arthritis: remission of proteinuria and renal function improvement with tocilizumab. (23669800)
2013
4
Renal and thyroid amyloidosis secondary tocryopyrin-associated periodic syndrome(Muckle-Wells syndrome) (NLRP3 mutation). (23511763)
2013
5
Cardiac amyloidosis secondary to multiple myeloma. (23882988)
2013
6
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
7
When first line therapy for AA-amyloidosis secondary to rheumatoid arthritis fails: a correspondence. (23022420)
2013
8
Amyloid goiter associated with amyloidosis secondary to rheumatoid arthritis. (24368922)
2013
9
Treatment with adalimumab in amyloidosis secondary to rheumatoid arthritis: two case reports. (23364579)
2013
10
The Effect of Etanercept on a Case of Amyloidosis Secondary to Ankylosing Spondylitis: Results of 2-Year Follow-Up. (24435036)
2013
11
Remission of proteinuria and preservation of renal function in patients with renal AA amyloidosis secondary to rheumatoid arthritis. (21771754)
2012
12
Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatments. (22011672)
2011
13
Pressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin: Transthyretin Cardiac Amyloid Study (TRACS). (21191093)
2011
14
Amyloidosis secondary to xanthogranulomatous pyelonephritis: a rare association. (20587879)
2010
15
Anakinra efficacy in a Caucasian patient with renal AA amyloidosis secondary to cryopyrin-associated periodic syndrome. (20609610)
2010
16
A hepatitis C-positive patient with new onset of nephrotic syndrome and systemic amyloidosis secondary to common variable immunodeficiency. (20697163)
2010
17
Renal AA amyloidosis secondary to morbid obesity? (19825338)
2009
18
Clinical strategies for amyloid A amyloidosis secondary to rheumatoid arthritis. (18369528)
2008
19
Amyloidosis secondary to hidradenitis suppurativa. Exceptional response to infliximab. (18848164)
2008
20
Recurrent subconjunctival and periorbital haemorrhage as the first presentation of systemic AL amyloidosis secondary to myeloma. (15905867)
2006
21
Significance of SAA1.3 allele genotype in Japanese patients with amyloidosis secondary to rheumatoid arthritis. (16219644)
2006
22
Resolution of acquired factor X deficiency with amyloidosis secondary to plasma cell dyscrasia. (15551292)
2004
23
Gustatory sweating due to autonomic neuropathy in a patient with amyloidosis secondary to rheumatoid arthritis. (24387731)
2004
24
A case of corneal lactoferrin amyloidosis secondary to trichiasis]. (12647336)
2003
25
Anti-tumor necrosis factor alpha therapy in fifteen patients with AA amyloidosis secondary to inflammatory arthritides: a followup report of tolerability and efficacy. (12847696)
2003
26
Efficacy of cyclophosphamide combined with prednisolone in patients with AA amyloidosis secondary to rheumatoid arthritis. (14677008)
2003
27
A novel single-nucleotide polymorphism at the 5'-flanking region of SAA1 associated with risk of type AA amyloidosis secondary to rheumatoid arthritis. (11407685)
2001
28
Spontaneous regression of bilateral surrenal haematoma and subclinical hypoaldosteronism in a patient with renal amyloidosis secondary to Familial Mediterranean Fever. (11229653)
2000
29
Gastrointestinal amyloidosis secondary to hypersensitivity vasculitis presenting with intestinal pseudoobstruction. (9724175)
1998
30
Chronic nephrotic syndrome and chronic renal failure by amyloidosis secondary to xanthogranulomatous pyelonephritis. (9491290)
1998
31
Pellagra associated with amyloidosis secondary to multiple myeloma. (9415256)
1997
32
A histopathological study of corneal amyloidosis secondary to trichiasis]. (8651059)
1996
33
Amyloidosis secondary to xanthogranulomatous pyelonephritis: an unusual case. (7646703)
1995
34
Generalized amyloidosis secondary to xanthogranulomatous pyelonephritis. (3816863)
1986
35
Amyloidosis, secondary to syphillis. (13055217)
1953

Variations for Amyloidosis, Secondary

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Expression for genes affiliated with Amyloidosis, Secondary

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Expression patterns in normal tissues for genes affiliated with Amyloidosis, Secondary

Search GEO for disease gene expression data for Amyloidosis, Secondary.

Pathways for genes affiliated with Amyloidosis, Secondary

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Pathways related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5APOA1, LCAT
29.5LTF, ALB
39.1TNF, APOA1
4
Show member pathways
9.1APOA1, SAA1, ALB
59.1TTR, APOA1, ALB
6
Show member pathways
9.0B2M, TNF, CTSB
7
Show member pathways
Vitamin B12 Metabolism37
8.9APOA1, SAA4, SAA2, SAA1
88.6TTR, B2M, APCS, APOA1, SAA1, LTF
98.6APOA1, ALB, CRP, LPA
10
Show member pathways
8.5ALB, LCAT, APOA1, LPA
11
Show member pathways
7.8TTR, LTF, SAA1, APOA1, APCS, TNF
12
Show member pathways
thioredoxin pathway37
7.2APOA1, TNF, ALB, CRP, SAA1, SAA2

Compounds for genes affiliated with Amyloidosis, Secondary

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Compounds related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1pmma449.8LTF, B2M, CRP
2gamma globulin449.6CRP, ALB, B2M
3pentosidine449.6ALB, CRP, B2M
4retinyl palmitate44 2410.6LCAT, APOA1, TTR
5nh4cl449.5CRP, B2M, CTSB
6probucol44 1110.3LCAT, LTF, APOA1
7dimyristoylphosphatidylcholine449.3LPA, APOA1, LCAT
8polysulfone449.3CRP, ALB, B2M
9vitamin b6449.3ALB, CRP, TTR, CTSB
10tenidap44 2810.2LTF, CRP, TNF, SAA1
11bezafibrate44 28 1111.2APOA1, LCAT, LPA, CRP
12rituximab44 50 1111.2CRP, SAA1, TNF, B2M
13iohexol449.1LTF, APOA1, B2M, ALB
14pravastatin44 50 28 24 1113.1LPA, LCAT, CRP, APOA1
1525-hydroxyvitamin d449.0TTR, APOA1, ALB, B2M, CRP
16folate448.9CRP, ALB, LPA, TTR, B2M
17sodium dodecylsulfate448.9TTR, ALB, LCAT, LPA
18glutamine448.9TTR, LCAT, B2M, CRP, CTSB, LTF
19urea44 24 1110.9CTSB, LPA, TTR, B2M, ALB
20hydrochlorothiazide44 28 50 24 1112.8ALB, CRP, APOA1
21fenofibrate44 50 1110.7TNF, APOA1, CRP, LPA
22iron44 249.7B2M, ALB, CRP, CTSB, TTR, LTF
23polyacrylamide448.5TTR, LTF, CTSB, LCAT, LPA, SAA4
24ascorbic acid44 249.4ALB, LTF, APOA1, TTR, CRP, LCAT
25cyclosporin a44 28 6110.4CTSB, TTR, TNF, B2M, LTF
26rosiglitazone28 44 50 24 1112.4LPA, ALB, CRP, TNF
27thyroxine44 249.4TTR, APOA1, ALB, CTSB, LPA, B2M
28testosterone44 61 24 1111.4B2M, TTR, CRP, ALB, LCAT, APOA1
29atorvastatin44 50 28 24 1112.4APOA1, LCAT, CRP, LPA, TNF
30endotoxin448.3LTF, TNF, SAA4, CRP, SAA1, MEFV
31alpha tocopherol448.3APOA1, SAA4, LCAT, CRP, TTR, ALB
32homocysteine44 249.2APOA1, SAA4, LPA, ALB, CRP, TTR
33aspartate448.2CTSB, CRP, ALB, APOA1, B2M, TTR
34vitamin b12448.2LTF, TTR, CRP, ALB, LPA, APOA1
35simvastatin44 50 61 28 24 1113.2SAA1, CRP, LPA, TNF, APOA1, LCAT
36neopterin448.1B2M, CTSB, CRP, LTF, TNF, TTR
37cysteine448.0LCAT, TTR, LTF, ALB, CTSB, LPA
38vegf448.0LPA, B2M, CRP, CTSB, TNF, LTF
39uric acid44 249.0TTR, B2M, LPA, SAA4, ALB, APOA1
40estrogen448.0LCAT, B2M, TTR, APOA1, SAA1, LPA
41indomethacin44 28 61 1110.9B2M, TNF, APOA1, ALB, CTSB, LTF
42vitamin a44 24 119.8B2M, TTR, APOA1, LPA, ALB, CRP
43lactate447.7B2M, TNF, TTR, APOA1, ALB, CTSB
44alanine447.6ALB, B2M, LTF, TTR, APOA1, LCAT
45glucose447.3TTR, APOA1, B2M, SAA4, SAA1, CRP
46creatinine447.3B2M, TTR, APOA1, SAA4, LPA, CTSB
47dexamethasone44 50 28 1110.1CTSB, LTF, LCAT, SAA1, TTR, SAA2
48cholesterol44 28 24 1110.0TTR, LPA, CTSB, B2M, CRP, ALB
49lipid446.8CRP, ALB, LCAT, SAA1, SAA4, APOA1
50fibrinogen446.5TTR, TNF, LTF, CTSB, CRP, ALB

GO Terms for genes affiliated with Amyloidosis, Secondary

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Cellular components related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.7SAA1, APOA1
2blood microparticleGO:0725628.8ALB, APOA1, APCS
3high-density lipoprotein particleGO:0343648.5LCAT, SAA1, SAA2, SAA4, APOA1
4extracellular vesicular exosomeGO:0700627.8B2M, APCS, APOA1, SAA1, ALB, CTSB
5extracellular spaceGO:0056156.3B2M, TNF, TTR, APCS, LTF, CTSB
6extracellular regionGO:0055765.2LTF, B2M, TNF, TTR, APCS, APOA1

Biological processes related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:0421589.8LCAT, APOA1
2cholesterol transportGO:0303019.7LCAT, APOA1
3high-density lipoprotein particle remodelingGO:0343759.7LCAT, APOA1
4reverse cholesterol transportGO:0436919.7APOA1, LCAT
5negative regulation of inflammatory responseGO:0507289.6MEFV, SAA1, APOA1
6phosphatidylcholine biosynthetic processGO:0066569.6LCAT, APOA1
7negative regulation of lipid storageGO:0108889.6TNF, CRP
8retina homeostasisGO:0018959.5B2M, ALB, LTF
9positive regulation of cytokine secretionGO:0507159.4TNF, SAA1
10negative regulation of cytokine secretion involved in immune responseGO:0027409.4APOA1, TNF
11defense response to Gram-positive bacteriumGO:0508309.4CRP, TNF
12acute-phase responseGO:0069539.2CRP, SAA1, SAA2, SAA4, APCS
13platelet activationGO:0301689.0ALB, SAA1, APOA1
14innate immune responseGO:0450879.0B2M, SAA1, MEFV, CTSB
15lipoprotein metabolic processGO:0421578.7APOA1, LPA, LCAT, ALB

Molecular functions related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.7CRP, APOA1
2identical protein bindingGO:0428028.5APOA1, TTR, TNF, B2M
3protein bindingGO:0055156.3B2M, TNF, TTR, APOA1, LCAT, ALB

Products for genes affiliated with Amyloidosis, Secondary

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Sources for Amyloidosis, Secondary

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet