MCID: AMY053
MIFTS: 52

Amyloidosis, Secondary malady

Neuronal diseases, Nephrological diseases, Bone diseases, Rare diseases categories

Summaries for Amyloidosis, Secondary

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MalaCards: Amyloidosis, Secondary, also known as secondary amyloidosis, is related to amyloidosis and arthritis. An important gene associated with Amyloidosis, Secondary is APCS (amyloid P component, serum), and among its related pathways are Statin Pathway and Selected targets of C EBPalpha. The compounds pmma and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Amyloidosis, Secondary

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50Orphanet, 48OMIM, 46Novoseek, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
secondary amyloidosis:
Prevalence: 1-5/10000


Aliases & Descriptions:

amyloidosis, secondary 48
secondary amyloidosis 50 63
inflammatory amyloidosis 50
amyloidosis secondary 46
reactive amyloidosis 50
amyloidosis aa 50


External Ids:

ICD10 via Orphanet27 E85.3
SNOMED-CT via Orphanet60 274945004, 281034005
UMLS via Orphanet64 C0221014

Related Diseases for Amyloidosis, Secondary

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18GeneCards, 19GeneDecks
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Diseases related to Amyloidosis, Secondary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 216)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis30.9SAA4, APOA1, APCS, TTR, B2M, SAA2
2arthritis30.8CTSB, TNF
3pyelonephritis30.6B2M, CRP
4rheumatoid arthritis30.3LPA, SAA1, SAA2, SAA4, APOA1, TNF
5rheumatic disease30.3TNF, MEFV, CRP
6familial mediterranean fever30.2TNF, MEFV
7diarrhea30.2TTR, ALB, CRP, LTF
8juvenile rheumatoid arthritis30.2TNF, CRP
9muckle-wells syndrome30.1MEFV
10ankylosing spondylitis30.1CRP, TNF
11ulcerative colitis30.1TNF, CRP, LTF
12proteinuria30.1B2M, TTR, APOA1, SAA4, LPA, LCAT
13nephrotic syndrome30.1B2M, APOA1, LPA, LCAT, ALB
14crohn's disease30.1TNF, ALB, CRP, LTF
15autonomic neuropathy30.0ALB, TTR
16behcet's disease30.0TNF, MEFV, CRP
17glomerulonephritis30.0ALB, LPA, B2M
18periodontal disease30.0LTF, CRP, TNF
19psoriatic arthritis30.0TNF, CRP
20periodontitis30.0TNF, CTSB, LTF
21hypertension29.9APOA1, LPA, ALB, CRP
22malaria29.9TNF, ALB
23alzheimer's disease29.9TTR, APCS, SAA4, LPA, CTSB
24inflammatory bowel disease29.9TNF, CRP, LTF
25vasculitis29.8TNF, MEFV, ALB, CRP, LTF
26obesity29.8TNF, APOA1, SAA4, LPA, LCAT, CRP
27amyloidosis aa10.6
28tuberculosis10.4
29leprosy10.4
30psoriasis10.3
31xanthogranulomatous pyelonephritis10.3
32multiple myeloma10.2
33myeloma10.2
34osteomyelitis10.2
35eye disease10.1CRP
36epidural abscess10.1CRP
37septic arthritis10.1CRP
38adult-onset still's disease10.1CRP
39chronic pyelonephritis10.1B2M
40cystic fibrosis10.1
41achalasia10.1
42gastritis10.1
43lupus erythematosus10.1
44scleroderma10.1
45spondylitis10.1
46al amyloidosis10.1
47spinal cord injury10.1
48erysipelas10.1MEFV
49palindromic rheumatism10.1MEFV
50bacteriuria10.1CRP

Graphical network of the top 20 diseases related to Amyloidosis, Secondary:



Diseases related to amyloidosis, secondary

Symptoms for Amyloidosis, Secondary

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Drugs & Therapeutics for Amyloidosis, Secondary

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Amyloidosis, Secondary

Drug clinical trials:

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Genetic Tests for Amyloidosis, Secondary

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Anatomical Context for Amyloidosis, Secondary

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34MalaCards
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MalaCards organs/tissues related to Amyloidosis, Secondary:

34
Bone, Thyroid

Animal Models for Amyloidosis, Secondary or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Amyloidosis, Secondary:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.6TNF, APCS, APOA1, MEFV, LCAT, LTF
2MP:00053877.2B2M, TNF, APCS, APOA1, MEFV, CRP
3MP:00053707.2B2M, TNF, APOA1, MEFV, LCAT, ALB
4MP:00053797.2B2M, TNF, APOA1, LCAT, ALB, CTSB
5MP:00053766.1LTF, B2M, TNF, TTR, APOA1, SAA1

Publications for Amyloidosis, Secondary

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53PubMed
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Articles related to Amyloidosis, Secondary:

(show all 34)
idTitleAuthorsYear
1
Sudden death possibly related to lenalidomide given for cardiac and muscle AL amyloidosis secondary to light chain deposition disease. (22504167)
2013
2
The permanent improvement of proteinuria and renal failure with colchicine and enalapril in a leukemic patient with renal amyloidosis secondary to ankylosing spondylitis: a review of the literature. (22975660)
2013
3
Renal amyloidosis secondary to rheumatoid arthritis: remission of proteinuria and renal function improvement with tocilizumab. (23669800)
2013
4
Renal and thyroid amyloidosis secondary tocryopyrin-associated periodic syndrome(Muckle-Wells syndrome) (NLRP3 mutation). (23511763)
2013
5
Cardiac amyloidosis secondary to multiple myeloma. (23882988)
2013
6
Hypoadrenal syndrome in a patient with amyloidosis secondary to familial Mediterranean fever. (23365166)
2013
7
When first line therapy for AA-amyloidosis secondary to rheumatoid arthritis fails: a correspondence. (23022420)
2013
8
Amyloid goiter associated with amyloidosis secondary to rheumatoid arthritis. (24368922)
2013
9
Treatment with adalimumab in amyloidosis secondary to rheumatoid arthritis: two case reports. (23364579)
2013
10
The Effect of Etanercept on a Case of Amyloidosis Secondary to Ankylosing Spondylitis: Results of 2-Year Follow-Up. (24435036)
2013
11
Remission of proteinuria and preservation of renal function in patients with renal AA amyloidosis secondary to rheumatoid arthritis. (21771754)
2012
12
Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatments. (22011672)
2011
13
Pressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin: Transthyretin Cardiac Amyloid Study (TRACS). (21191093)
2011
14
Amyloidosis secondary to xanthogranulomatous pyelonephritis: a rare association. (20587879)
2010
15
Anakinra efficacy in a Caucasian patient with renal AA amyloidosis secondary to cryopyrin-associated periodic syndrome. (20609610)
2010
16
A hepatitis C-positive patient with new onset of nephrotic syndrome and systemic amyloidosis secondary to common variable immunodeficiency. (20697163)
2010
17
Renal AA amyloidosis secondary to morbid obesity? (19825338)
2009
18
Clinical strategies for amyloid A amyloidosis secondary to rheumatoid arthritis. (18369528)
2008
19
Amyloidosis secondary to hidradenitis suppurativa. Exceptional response to infliximab. (18848164)
2008
20
Recurrent subconjunctival and periorbital haemorrhage as the first presentation of systemic AL amyloidosis secondary to myeloma. (15905867)
2006
21
Significance of SAA1.3 allele genotype in Japanese patients with amyloidosis secondary to rheumatoid arthritis. (16219644)
2006
22
Resolution of acquired factor X deficiency with amyloidosis secondary to plasma cell dyscrasia. (15551292)
2004
23
Gustatory sweating due to autonomic neuropathy in a patient with amyloidosis secondary to rheumatoid arthritis. (24387731)
2004
24
A case of corneal lactoferrin amyloidosis secondary to trichiasis]. (12647336)
2003
25
Anti-tumor necrosis factor alpha therapy in fifteen patients with AA amyloidosis secondary to inflammatory arthritides: a followup report of tolerability and efficacy. (12847696)
2003
26
Efficacy of cyclophosphamide combined with prednisolone in patients with AA amyloidosis secondary to rheumatoid arthritis. (14677008)
2003
27
A novel single-nucleotide polymorphism at the 5'-flanking region of SAA1 associated with risk of type AA amyloidosis secondary to rheumatoid arthritis. (11407685)
2001
28
Spontaneous regression of bilateral surrenal haematoma and subclinical hypoaldosteronism in a patient with renal amyloidosis secondary to Familial Mediterranean Fever. (11229653)
2000
29
Gastrointestinal amyloidosis secondary to hypersensitivity vasculitis presenting with intestinal pseudoobstruction. (9724175)
1998
30
Chronic nephrotic syndrome and chronic renal failure by amyloidosis secondary to xanthogranulomatous pyelonephritis. (9491290)
1998
31
Pellagra associated with amyloidosis secondary to multiple myeloma. (9415256)
1997
32
A histopathological study of corneal amyloidosis secondary to trichiasis]. (8651059)
1996
33
Amyloidosis secondary to xanthogranulomatous pyelonephritis: an unusual case. (7646703)
1995
34
Generalized amyloidosis secondary to xanthogranulomatous pyelonephritis. (3816863)
1986

Variations for Amyloidosis, Secondary

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Expression for genes affiliated with Amyloidosis, Secondary

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyloidosis, Secondary

Search GEO for disease gene expression data for Amyloidosis, Secondary.

Pathways for genes affiliated with Amyloidosis, Secondary

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51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 13EMD Millipore, 31KEGG, 56Reactome, 54QIAGEN
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Pathways related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5LCAT, APOA1
29.5LTF, ALB
39.1APOA1, TNF
4
Show member pathways
9.1APOA1, SAA1, ALB
59.1ALB, APOA1, TTR
6
Show member pathways
9.0B2M, TNF, CTSB
7
Show member pathways
Vitamin B12 Metabolism39
8.9APOA1, SAA4, SAA2, SAA1
88.6B2M, TTR, APCS, APOA1, SAA1, LTF
98.6CRP, ALB, LPA, APOA1
10
Show member pathways
8.5APOA1, LPA, LCAT, ALB
11
Show member pathways
7.8B2M, TNF, TTR, APCS, APOA1, SAA1
12
Show member pathways
thioredoxin pathway39
7.2CRP, TNF, APOA1, SAA4, SAA2, SAA1

Compounds for genes affiliated with Amyloidosis, Secondary

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1pmma469.8LTF, B2M, CRP
2gamma globulin469.6CRP, ALB, B2M
3pentosidine469.6ALB, CRP, B2M
4retinyl palmitate46 2510.6LCAT, APOA1, TTR
5nh4cl469.5CRP, B2M, CTSB
6probucol46 1210.3LCAT, LTF, APOA1
7dimyristoylphosphatidylcholine469.3LPA, APOA1, LCAT
8polysulfone469.3CRP, ALB, B2M
9vitamin b6469.3ALB, CRP, TTR, CTSB
10tenidap46 3010.2LTF, CRP, TNF, SAA1
11bezafibrate46 30 1211.2APOA1, LCAT, LPA, CRP
12rituximab46 52 1211.2CRP, SAA1, TNF, B2M
13iohexol469.1LTF, APOA1, B2M, ALB
14pravastatin46 52 30 25 1213.1LPA, LCAT, CRP, APOA1
1525-hydroxyvitamin d469.0TTR, APOA1, ALB, B2M, CRP
16folate468.9CRP, ALB, LPA, TTR, B2M
17sodium dodecylsulfate468.9TTR, ALB, LCAT, LPA
18glutamine468.9TTR, LCAT, B2M, CRP, CTSB, LTF
19urea46 25 1210.9CTSB, LPA, TTR, B2M, ALB
20hydrochlorothiazide46 30 52 25 1212.8ALB, CRP, APOA1
21fenofibrate46 52 1210.7TNF, APOA1, CRP, LPA
22iron46 259.7B2M, ALB, CRP, CTSB, TTR, LTF
23polyacrylamide468.5TTR, LTF, CTSB, LCAT, LPA, SAA4
24ascorbic acid46 259.4ALB, LTF, APOA1, TTR, CRP, LCAT
25cyclosporin a46 30 6210.4CTSB, TTR, TNF, B2M, LTF
26rosiglitazone30 46 52 25 1212.4LPA, ALB, CRP, TNF
27thyroxine46 259.4TTR, APOA1, ALB, CTSB, LPA, B2M
28testosterone46 62 25 1211.4B2M, TTR, CRP, ALB, LCAT, APOA1
29atorvastatin46 52 30 25 1212.4APOA1, LCAT, CRP, LPA, TNF
30endotoxin468.3LTF, TNF, SAA4, CRP, SAA1, MEFV
31alpha tocopherol468.3APOA1, SAA4, LCAT, CRP, TTR, ALB
32homocysteine46 259.2APOA1, SAA4, LPA, ALB, CRP, TTR
33aspartate468.2CTSB, CRP, ALB, APOA1, B2M, TTR
34vitamin b12468.2LTF, TTR, CRP, ALB, LPA, APOA1
35simvastatin46 52 62 30 25 1213.2SAA1, CRP, LPA, TNF, APOA1, LCAT
36neopterin468.1B2M, CTSB, CRP, LTF, TNF, TTR
37cysteine468.0LCAT, TTR, LTF, ALB, CTSB, LPA
38vegf468.0LPA, B2M, CRP, CTSB, TNF, LTF
39uric acid46 259.0TTR, B2M, LPA, SAA4, ALB, APOA1
40estrogen468.0LCAT, B2M, TTR, APOA1, SAA1, LPA
41indomethacin46 30 62 1210.9B2M, TNF, APOA1, ALB, CTSB, LTF
42vitamin a46 25 129.8B2M, TTR, APOA1, LPA, ALB, CRP
43lactate467.7B2M, TNF, TTR, APOA1, ALB, CTSB
44alanine467.6ALB, B2M, LTF, TTR, APOA1, LCAT
45glucose467.3TTR, APOA1, B2M, SAA4, SAA1, CRP
46creatinine467.3B2M, TTR, APOA1, SAA4, LPA, CTSB
47dexamethasone46 52 30 1210.1CTSB, LTF, LCAT, SAA1, TTR, SAA2
48cholesterol46 30 25 1210.0TTR, LPA, CTSB, B2M, CRP, ALB
49lipid466.8CRP, ALB, LCAT, SAA1, SAA4, APOA1
50fibrinogen466.5TTR, TNF, LTF, CTSB, CRP, ALB

GO Terms for genes affiliated with Amyloidosis, Secondary

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17Gene Ontology
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Cellular components related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.7SAA1, APOA1
2blood microparticleGO:0725628.8ALB, APOA1, APCS
3high-density lipoprotein particleGO:0343648.5APOA1, SAA4, SAA2, SAA1, LCAT
4extracellular vesicular exosomeGO:0700627.8B2M, APCS, APOA1, SAA1, ALB, CTSB
5extracellular spaceGO:0056156.3B2M, TNF, TTR, APCS, APOA1, LCAT
6extracellular regionGO:0055765.2LTF, B2M, TNF, TTR, APCS, APOA1

Biological processes related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:0421589.8LCAT, APOA1
2cholesterol transportGO:0303019.7LCAT, APOA1
3high-density lipoprotein particle remodelingGO:0343759.7LCAT, APOA1
4reverse cholesterol transportGO:0436919.7APOA1, LCAT
5negative regulation of inflammatory responseGO:0507289.6MEFV, SAA1, APOA1
6phosphatidylcholine biosynthetic processGO:0066569.6LCAT, APOA1
7negative regulation of lipid storageGO:0108889.6TNF, CRP
8retina homeostasisGO:0018959.5B2M, ALB, LTF
9positive regulation of cytokine secretionGO:0507159.4TNF, SAA1
10negative regulation of cytokine secretion involved in immune responseGO:0027409.4APOA1, TNF
11defense response to Gram-positive bacteriumGO:0508309.4CRP, TNF
12acute-phase responseGO:0069539.2CRP, SAA1, SAA2, SAA4, APCS
13platelet activationGO:0301689.0ALB, SAA1, APOA1
14innate immune responseGO:0450879.0B2M, SAA1, MEFV, CTSB
15lipoprotein metabolic processGO:0421578.7APOA1, LPA, LCAT, ALB

Molecular functions related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.7CRP, APOA1
2identical protein bindingGO:0428028.5APOA1, TTR, TNF, B2M
3protein bindingGO:0055156.3B2M, TNF, TTR, APOA1, LCAT, ALB

Products for genes affiliated with Amyloidosis, Secondary

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amyloidosis, Secondary

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet