MCID: AMY053
MIFTS: 43

Amyloidosis, Secondary malady

Neuronal diseases, Nephrological diseases, Bone diseases categories

Summaries for Amyloidosis, Secondary

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MalaCards: Amyloidosis, Secondary, also known as secondary amyloidosis, is related to amyloidosis and arthritis. An important gene associated with Amyloidosis, Secondary is APCS (amyloid P component, serum), and among its related pathways are Scavenging by Class B Receptors and Folate Metabolism. The compounds dimyristoylphosphatidylcholine and glucose have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Classifications for Amyloidosis, Secondary

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46OMIM, 44Novoseek, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
secondary amyloidosis:
Prevalence: 1-5/10000


Aliases & Descriptions:

amyloidosis, secondary 46
secondary amyloidosis 48 60
inflammatory amyloidosis 48
amyloidosis secondary 44
reactive amyloidosis 48
amyloidosis aa 48


External Ids:

ICD10 via Orphanet26 E85.3
SNOMED-CT via Orphanet57 274945004, 281034005
UMLS via Orphanet61 C0221014

Related Diseases for Amyloidosis, Secondary

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17GeneCards, 18GeneDecks
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Diseases related to Amyloidosis, Secondary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis36.2APCS, CTSB, LPA, CRP, MEFV, B2M
2arthritis35.6SAA4, SAA1, TNF, CTSB, MEFV, B2M
3rheumatoid arthritis35.6SAA4, SAA2, LPA, SAA1, TNF, CTSB
4proteinuria35.2SAA4, CRP, LCAT, LPA, APOA1, B2M
5familial mediterranean fever35.1MEFV, TNF
6nephrotic syndrome35.1B2M, LPA, APOA1, LCAT, ALB
7hepatitis c34.8ALB, CTSB
8alzheimer's disease34.8CTSB, TTR, LPA, APCS, SAA4
9behcet's disease34.8TNF, CRP, MEFV
10cholestasis34.8LCAT, ALB
11glomerulonephritis34.8ALB, LPA, B2M
12hypertension34.8ALB, LPA, APOA1, CRP
13multiple sclerosis34.8APOA1, ALB, TNF
14obesity34.8SAA4, LCAT, TNF, APOA1, LPA, CRP
15periodontal disease34.8CRP, LTF, TNF, CTSB
16periodontitis34.8CTSB, TNF, LTF
17vasculitis34.8TNF, CRP, MEFV, LTF, ALB
18crohn's disease30.5TNF, LTF, ALB, CRP
19psoriasis30.4LTF, TNF
20pyelonephritis30.3B2M, CRP
21multiple myeloma30.2B2M
22reactive arthritis30.1CRP, LTF
23gastritis30.1LTF
24ankylosing spondylitis30.1TNF, CRP
25cystic fibrosis30.1ALB, LTF
26diarrhea30.1TTR, CRP, LTF, ALB
27ulcerative colitis30.1CRP, ALB, TNF, LTF
28hepatitis29.9TTR
29systemic lupus erythematosus29.9CRP
30chronic pyelonephritis29.9B2M
31gingivitis29.9LTF
32psoriatic arthritis29.9CRP, TNF
33neuropathy29.9TTR, ALB
34malaria29.9TNF, ALB
35connective tissue disease29.9ALB, TNF
36peripheral vascular disease13.3LPA, APOA1, ALB
37deficiency anemia13.3ALB, B2M, CRP, SAA1, LCAT, TTR
38stroke, ischemic13.3APOA1, ALB, CRP, LPA
39diabetic nephropathy13.3APOA1, B2M, LPA, ALB
40coronary artery disease13.3SAA4, SAA1, LPA, CRP, LCAT, APOA1
41gout13.3LCAT
42acute pancreatitis13.3CRP, CTSB
43tangier disease13.3APOA1, LCAT, LPA
44abetalipoproteinemia13.3LCAT, APOA1
45hypobetalipoproteinemia13.3LCAT, APOA1
46norum disease13.3APOA1, LCAT
47alcohol abuse13.3LCAT
48obstructive jaundice13.3LCAT, TTR
49arcus senilis13.3LCAT, APOA1
50erysipelas13.3MEFV

Graphical network of the top 20 diseases related to Amyloidosis, Secondary:



Diseases related to amyloidosis, secondary

Clinical Features for Amyloidosis, Secondary

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Drugs & Therapeutics for Amyloidosis, Secondary

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Amyloidosis, Secondary

Drug clinical trials:

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Search NIH Clinical Center for Amyloidosis, Secondary

Search CenterWatch for Amyloidosis, Secondary

Genetic Tests for Amyloidosis, Secondary

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Anatomical Context for Amyloidosis, Secondary

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32MalaCards
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MalaCards organs/tissues related to Amyloidosis, Secondary:

32
Bone

Animal Models for Amyloidosis, Secondary or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Amyloidosis, Secondary:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5LTF, B2M, APCS, TNF
2MP:00053708.0ALB, LTF, B2M, TNF
3MP:00053877.7B2M, CRP, APCS, TNF, LTF
4MP:00053766.7TTR, ALB, B2M, CRP, TNF, SAA1

Publications for Amyloidosis, Secondary

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Genetic Variations for Amyloidosis, Secondary

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Expression for genes affiliated with Amyloidosis, Secondary

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyloidosis, Secondary

Search GEO for disease gene expression data for Amyloidosis, Secondary.

Pathways for genes affiliated with Amyloidosis, Secondary

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1SAA1
210.1SAA1
3
Hide members
9.7ALB
49.3SAA1, ALB
59.2ALB, TTR
69.1CRP, ALB
78.3APCS, B2M, LTF, TTR, SAA1
8
Hide members
8.3B2M, LTF, TTR, APCS, SAA1
98.2SAA1, TNF, CRP, ALB

Compounds for genes affiliated with Amyloidosis, Secondary

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1dimyristoylphosphatidylcholine4410.7
2glucose4410.5SAA1
3alpha tocopherol4410.5TTR
4pdpc4410.5
5retinyl palmitate44 2411.4TTR
6bezafibrate44 28 1112.3CRP
7vitamin a44 11 2412.3LTF
8pravastatin44 49 28 11 2414.2CRP
9probucol44 1111.1LTF
10uric acid44 2411.1TTR, B2M
11nh4cl449.9B2M
12dexamethasone44 49 28 1112.9SAA1, LTF
13tenidap44 2810.9LTF, SAA1
14endotoxin449.9SAA1, LTF
15polyacrylamide449.8TTR, LTF
16estrogen449.8LTF, TTR
17atorvastatin44 49 28 11 2413.8TNF, CRP
18fenofibrate44 49 1111.8TNF, CRP
19pentosidine449.5ALB, B2M
20sodium dodecylsulfate449.5TTR, ALB
21simvastatin44 49 59 28 11 2414.5SAA1, CRP, TNF
22idpn449.3ALB, TTR
23iron44 2410.3LTF, TTR, B2M
24hydrochlorothiazide44 49 28 11 2413.3ALB, CRP
25thyroxine44 2410.2B2M, TTR, ALB
26urea44 11 2411.2ALB, TTR, B2M
27homocysteine44 2410.2ALB, TTR, CRP
28pmma449.1CRP, LTF, B2M
29vitamin b6449.1ALB, TTR, CRP
30gamma globulin449.0ALB, CRP, B2M
31iohexol449.0ALB, LTF, B2M
32polysulfone448.8ALB, B2M, CRP
33glutamine448.8LTF, CRP, TTR, B2M
3425-hydroxyvitamin d448.7B2M, ALB, TTR, CRP
35folate448.6TTR, B2M, ALB, CRP
36aspartate448.6LTF, TTR, ALB, B2M
37cellulose acetate448.5ALB, TTR, B2M
38ascorbic acid44 249.5ALB, TTR, LTF, CRP
39testosterone44 59 11 2411.4ALB, TTR, B2M, CRP
40indomethacin44 59 28 1111.4ALB, LTF, B2M, TNF
41cysteine448.4LTF, ALB, TTR, B2M
42neopterin448.4TTR, LTF, B2M, CRP, TNF
43cholesterol44 28 11 2411.3SAA1, ALB, TTR, CRP, B2M
44lipid448.3ALB, CRP, SAA1, APCS, TNF
45hyaluronic acid44 249.2LTF, TTR, ALB, B2M
46lactate448.1ALB, TTR, B2M, CRP, TNF
47vitamin b12448.1ALB, TTR, LTF, B2M, CRP
48creatinine448.1TTR, CRP, ALB, B2M, LTF
49alanine447.7CRP, B2M, ALB, LTF, TTR, SAA1
50fibrinogen447.7TTR, CRP, LTF, TNF, SAA1, ALB

GO Terms for genes affiliated with Amyloidosis, Secondary

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16Gene Ontology
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Cellular components related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.1SAA1
2high-density lipoprotein particleGO:03436410.0SAA1
3extracellular spaceGO:0056157.1TNF, APCS, CRP, B2M, TTR, ALB
4extracellular regionGO:0055766.4ALB, SAA1, TNF, APCS, CRP, B2M

Biological processes related to Amyloidosis, Secondary according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:04215810.6
2negative regulation of cytokine secretion involved in immune responseGO:00274010.5
3reverse cholesterol transportGO:04369110.5
4high-density lipoprotein particle remodelingGO:03437510.4
5negative regulation of inflammatory responseGO:05072810.3SAA1
6cholesterol transportGO:03030110.2
7lipoprotein metabolic processGO:0421579.8ALB
8acute-phase responseGO:0069539.4CRP, APCS, SAA1
9negative regulation of lipid storageGO:0108889.4TNF, CRP

Products for genes affiliated with Amyloidosis, Secondary

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amyloidosis, Secondary

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet