ALS
MCID: AMY001
MIFTS: 66

Amyotrophic Lateral Sclerosis (ALS) malady

Genetic diseases, Neuronal diseases, Rare diseases, Mental diseases categories

Summaries for Amyotrophic Lateral Sclerosis

About this section


Disease Ontology:9 A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.

MalaCards based summary: Amyotrophic Lateral Sclerosis, also known as motor neuron disease, bulbar, is related to lateral sclerosis and motor neuron disease. An important gene associated with Amyotrophic Lateral Sclerosis is SETX (senataxin), and among its related pathways is Amyotrophic lateral sclerosis (ALS). The drug riluzole has been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related mouse phenotype behavior/neurological.

Descriptions from OMIM:46 602433, 205100, 611895, 613435, 608030 612069, 612577, 105400 more

Aliases & Classifications for Amyotrophic Lateral Sclerosis

About this section

Amyotrophic Lateral Sclerosis, Aliases & Descriptions:

Name: Amyotrophic Lateral Sclerosis 31 9 61
Motor Neuron Disease, Bulbar 9
 
Lou Gehrig's Disease 9
Als 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Mental diseases


External Ids:

Disease Ontology9 DOID:332
ICD9CM28 335.20
SNOMED-CT56 86044005
MeSH34 D000690
NCIt39 C34373

Related Diseases for Amyotrophic Lateral Sclerosis

About this section

Diseases in the Amyotrophic Lateral Sclerosis Type 14 family:

amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis Type 8
Amyotrophic Lateral Sclerosis Type 3 Amyotrophic Lateral Sclerosis Type 1
Amyotrophic Lateral Sclerosis Type 2 Amyotrophic Lateral Sclerosis Type 4
Amyotrophic Lateral Sclerosis Type 5 Amyotrophic Lateral Sclerosis Type 6
Amyotrophic Lateral Sclerosis Type 7 Amyotrophic Lateral Sclerosis Type 19
Amyotrophic Lateral Sclerosis Type 21 Amyotrophic Lateral Sclerosis Type 17
Amyotrophic Lateral Sclerosis Type 20 Amyotrophic Lateral Sclerosis Type 18
Amyotrophic Lateral Sclerosis Type 13 Amyotrophic Lateral Sclerosis Type 15
Amyotrophic Lateral Sclerosis Type 16 Amyotrophic Lateral Sclerosis Type 11
Amyotrophic Lateral Sclerosis Type 12 Amyotrophic Lateral Sclerosis Type 9
Amyotrophic Lateral Sclerosis Type 10 Tardbp-Related Amyotrophic Lateral Sclerosis
Sod1-Related Amyotrophic Lateral Sclerosis Autosomal Recessive Juvenile Amyotrophic Lateral Sclerosis
Vapb-Related Amyotrophic Lateral Sclerosis Setx-Related Amyotrophic Lateral Sclerosis
Ang-Related Amyotrophic Lateral Sclerosis Fus-Related Amyotrophic Lateral Sclerosis
Fig4-Related Amyotrophic Lateral Sclerosis Optn-Related Amyotrophic Lateral Sclerosis
Pfn1-Related Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 16, Juvenile
Amyotrophic Lateral Sclerosis 5, Juvenile Recessive

Diseases related to Amyotrophic Lateral Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 2927)
idRelated DiseaseScoreTop Affiliating Genes
1lateral sclerosis33.1ALS2, SOD1
2motor neuron disease31.9SOD1, NEFH, ALS2
3frontotemporal dementia31.9FUS, C9orf72, SOD1
4amyotrophic lateral sclerosis type 1431.5ALS2, FUS, C9orf72, SETX, SOD1, NEFH
5aphasia30.9FUS, C9orf72
6neuronitis11.4
7dementia11.2
8al amyloidosis10.9
9amyotrophic lateral sclerosis type 210.9
10muscular atrophy10.9
11amyotrophic lateral sclerosis type 410.9
12endotheliitis10.8
13amyotrophic lateral sclerosis-parkinsonism/dementia complex10.8
14alzheimer's disease10.7
15parkinson's disease10.7
16progressive muscular atrophy10.7
17amyotrophic lateral sclerosis type 810.7
18ftdals110.7
19neuropathy10.7
20amyotrophic lateral sclerosis type 610.7
21amyotrophic lateral sclerosis type 1710.7
22amyotrophic lateral sclerosis type 1810.7
23amyotrophic lateral sclerosis type 1110.7
24amyotrophic lateral sclerosis type 910.7
25spasticity10.7
26multiple sclerosis10.7
27spinal muscular atrophy10.7
28amyotrophic lateral sclerosis type 310.7
29amyotrophic lateral sclerosis type 710.7
30amyotrophic lateral sclerosis type 1010.7
31hyperlipidemia type 310.7
32werdnig-hoffmann disease10.6
33amyotrophic lateral sclerosis type 110.6
34amyotrophic lateral sclerosis type 1210.6
35pick's disease10.6
36amyotrophic lateral sclerosis type 510.6
37cerebritis10.6
38cervicitis10.6
39amyotrophic lateral sclerosis 14, with or without frontotemporal dementia10.6
40multifocal motor neuropathy10.6
41amyotrophic lateral sclerosis type 1910.6
42tauopathy10.6
43amyotrophic lateral sclerosis-parkinsonism/dementia complex 110.6
44dysphagia10.6
45blindness10.6
46split hand10.6
47huntington's disease10.5
48amyotrophic lateral sclerosis type 2110.5
49amyotrophic lateral sclerosis type 2010.5
50amyotrophic lateral sclerosis type 1310.5

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis:



Diseases related to amyotrophic lateral sclerosis

Symptoms for Amyotrophic Lateral Sclerosis

About this section


Clinical features from OMIM:

602433,205100,611895,613435,608030,612069,612577,105400

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis

About this section

Drug clinical trials:

Search ClinicalTrials for Amyotrophic Lateral Sclerosis

Search NIH Clinical Center for Amyotrophic Lateral Sclerosis

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Amyotrophic Lateral Sclerosis cell therapies at LifeMap Discovery.

Genetic Tests for Amyotrophic Lateral Sclerosis

About this section

Anatomical Context for Amyotrophic Lateral Sclerosis

About this section

MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis:

32
Spinal cord, Bone, Brain, Cortex, Skin, Endothelial, Skeletal muscle, Bone marrow, Testes, Monocytes, Tongue, Eye, Salivary gland, Pituitary, Whole blood, Cerebellum, Liver, Breast, Prostate, Temporal lobe, Amygdala

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Amyotrophic Lateral Sclerosis:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
4 Neural TubeMotor Neural Progenitor DomainMotor Neural Progenitor Cells Potential therapeutic candidate
5 Neural TubeMotor Neural Progenitor DomainMotor Neurons Potential therapeutic candidate, affected by disease
6 BrainForebrain White MatterMyelinating Oligodendrocyte Cells Affected by disease
7 Spinal CordSpinal Cord White MatterMyelinating Oligodendrocyte Cells Affected by disease
8 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Amyotrophic Lateral Sclerosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Amyotrophic Lateral Sclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.7TRPM7, SIGMAR1, ALS2, CARF, FAM117B, NEFH

Publications for Amyotrophic Lateral Sclerosis

About this section

Articles related to Amyotrophic Lateral Sclerosis:

(show top 50)    (show all 1874)
idTitleAuthorsYear
1
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis. (24833719)
2014
2
Depressed excitability and ion currents linked to slow exocytotic fusion pore in chromaffin cells of the SOD1G93A mouse model of amyotrophic lateral sclerosis. (25377090)
2014
3
ALS2 mutations: juvenile amyotrophic lateral sclerosis and generalized dystonia. (24562058)
2014
4
Limb-onset amyotrophic lateral sclerosis patients visiting orthopedist show a longer time-to-diagnosis since symptom onset. (23394455)
2013
5
Carnitine deficiency presenting with a decreased mental state in a patient with amyotrophic lateral sclerosis receiving long-term tube feeding: a case report. (24377720)
2013
6
Genetics of amyotrophic lateral sclerosis: an update. (23941283)
2013
7
PGC-1I+ is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis. (23669350)
2013
8
Two case reports of an unusual association between Klippel-Feil syndrome and amyotrophic lateral sclerosis: Do they share same genetic defect? (24339616)
2013
9
Characterization of Wnt/I^-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis. (24348333)
2013
10
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. (22922411)
2012
11
TARDBP gene mutations among Chinese patients with sporadic amyotrophic lateral sclerosis. (20708823)
2012
12
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. (22406228)
2012
13
Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis. (22430187)
2012
14
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. (22993125)
2012
15
Sporadic juvenile amyotrophic lateral sclerosis caused by mutant FUS/TLS: possible association of mental retardation with this mutation. (22057404)
2012
16
CGG-repeat expansion in FMR1 is not associated with amyotrophic lateral sclerosis. (22507827)
2012
17
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
18
Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients. (21226712)
2011
19
Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: specificity, sensitivity, and a possible prognostic value. (21126161)
2011
20
Vascular endothelial growth factor attenuates neurodegenerative changes in the NSC-34 motor neuron cell line induced by cerebrospinal fluid of sporadic amyotrophic lateral sclerosis patients. (21389676)
2011
21
Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis. (20648658)
2010
22
Superficial siderosis mimicking amyotrophic lateral sclerosis. (20215988)
2010
23
Analysis of the UNC13A gene as a risk factor for sporadic amyotrophic lateral sclerosis. (20385924)
2010
24
A novel mutation in the senataxin gene identified in a Chinese patient with sporadic amyotrophic lateral sclerosis. (19058054)
2009
25
CSF hypocretin-1 levels are normal in patients with amyotrophic lateral sclerosis. (19922146)
2009
26
Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation. (18022844)
2008
27
Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis. (16737688)
2006
28
Histological recovery of the hepatocytes is based on the redox system upregulation in the animal models of mutant superoxide dismutase (SOD)1-linked amyotrophic lateral sclerosis. (16598672)
2006
29
Primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis: discrete entities or spectrum? (16036421)
2005
30
Expression of an endoplasmic reticulum-resident chaperone, glucose-regulated stress protein 78, in the spinal cord of a mouse model of amyotrophic lateral sclerosis. (16231159)
2005
31
Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis. (15753080)
2005
32
DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). (15106121)
2004
33
Decreased galectin-1 immunoreactivity of the skin in amyotrophic lateral sclerosis. (12639727)
2003
34
Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosis. (12768434)
2003
35
The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis. (12729761)
2003
36
No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis. (12358770)
2002
37
Amyotrophic lateral sclerosis and SOD1 gene: an overview. (11996514)
2001
38
Genetics of amyotrophic lateral sclerosis. (19714405)
2000
39
Manganese superoxide dismutase levels are elevated in a proportion of amyotrophic lateral sclerosis patient cell lines. (10873611)
2000
40
Unaltered cytochrome oxidase, glutamate dehydrogenase and glutaminase activities in platelets from patients with sporadic amyotrophic lateral sclerosis--a study of potential pathogenetic mechanisms in neurodegenerative diseases. (11458996)
2000
41
Simple and defined method to detect the SOD-1 mutants from patients with familial amyotrophic lateral sclerosis by mass spectrometry. (9696308)
1998
42
A novel SOD1 mutation in an Austrian family with amyotrophic lateral sclerosis. (9131652)
1997
43
A missense mutation in the SOD1 gene in patients with amyotrophic lateral sclerosis from the Kii Peninsula and its vicinity, Japan. (10732812)
1997
44
Muscarinic, N-methyl-D-aspartate (NMDA) and benzodiazepine receptor binding sites in cortical membranes from amyotrophic lateral sclerosis patients. (8981309)
1996
45
Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis. (8899655)
1996
46
Amyotrophic lateral sclerosis associated with multiple myeloma, endocrinopathy and skin changes suggestive of a POEMS syndrome variant. (7595623)
1995
47
Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins. (7717459)
1995
48
Cu/Zn superoxide dismutase (SOD1) mutations and sporadic amyotrophic lateral sclerosis. (8105280)
1993
49
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. (8351519)
1993
50
Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: an immunohistochemical study. (2161095)
1990

Variations for Amyotrophic Lateral Sclerosis

About this section

Expression for genes affiliated with Amyotrophic Lateral Sclerosis

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Amyotrophic Lateral Sclerosis patients vs. healthy controls: 31 (show all 142)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ACTN3actinin, alpha 3Skeletal Muscle-5.490.000
2MYH8myosin, heavy chain 8, skeletal muscle, perinatalSkeletal Muscle+3.890.000
3PRUNE2prune homolog 2 (Drosophila)Skeletal Muscle+3.830.001
4CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)Skeletal Muscle+3.820.000
5COL19A1collagen, type XIX, alpha 1Skeletal Muscle+3.770.000
6LRRK2leucine-rich repeat kinase 2Skeletal Muscle+3.670.001
7FSTfollistatinSkeletal Muscle+3.470.001
8CERKLceramide kinase-likeSkeletal Muscle+3.460.000
9RMDN2regulator of microtubule dynamics 2Skeletal Muscle+3.440.005
10MYLK2myosin light chain kinase 2Skeletal Muscle-3.270.009
11MUSKmuscle, skeletal, receptor tyrosine kinaseSkeletal Muscle+3.220.001
12HOXC10homeobox C10Skeletal Muscle-3.220.000
13SESN3sestrin 3Skeletal Muscle+3.190.007
14CPNE8copine VIIISkeletal Muscle+3.060.001
15GADD45Agrowth arrest and DNA-damage-inducible, alphaSkeletal Muscle+3.000.009
16IGFN1immunoglobulin-like and fibronectin type III domain containing 1Skeletal Muscle-2.990.005
17CHRNGcholinergic receptor, nicotinic, gamma (muscle)Skeletal Muscle+2.980.001
18KLHL38kelch-like family member 38Skeletal Muscle-2.980.023
19ACTC1actin, alpha, cardiac muscle 1Skeletal Muscle+2.900.002
20ARHGAP28Rho GTPase activating protein 28Skeletal Muscle+2.880.004
21MYBPC2myosin binding protein C, fast typeSkeletal Muscle-2.740.004
22GPR98G protein-coupled receptor 98Skeletal Muscle+2.720.000
23CLLU1chronic lymphocytic leukemia up-regulated 1Skeletal Muscle+2.680.006
24ANXA1annexin A1Skeletal Muscle+2.620.040
25PREPLprolyl endopeptidase-likeSkeletal Muscle+2.600.001
26ENO3enolase 3 (beta, muscle)Skeletal Muscle-2.540.004
27GXYLT2glucoside xylosyltransferase 2Skeletal Muscle+2.540.045
28PGAM2phosphoglycerate mutase 2 (muscle)Skeletal Muscle-2.530.009
29CFHcomplement factor HSkeletal Muscle+2.510.016
30RNU5D-1RNA, U5D small nuclear 1Skeletal Muscle+2.460.003
31UCP3uncoupling protein 3 (mitochondrial, proton carrier)Skeletal Muscle-2.450.001
32SIM1single-minded family bHLH transcription factor 1Skeletal Muscle-2.430.000
33FBP2fructose-1,6-bisphosphatase 2Skeletal Muscle-2.420.020
34NPR3natriuretic peptide receptor 3Skeletal Muscle-2.390.001
35MEGF10multiple EGF-like-domains 10Skeletal Muscle+2.350.001
36ASB2ankyrin repeat and SOCS box containing 2Skeletal Muscle-2.330.019
37PTGFRprostaglandin F receptor (FP)Skeletal Muscle+2.290.003
38SLC47A2solute carrier family 47 (multidrug and toxin extrusion), member 2Skeletal Muscle+2.290.002
39OSBPL8oxysterol binding protein-like 8Skeletal Muscle+2.260.050
40LIPJlipase, family member JSkeletal Muscle+2.250.004
41EFCAB7EF-hand calcium binding domain 7Skeletal Muscle+2.250.015
42ZNF385Dzinc finger protein 385DSkeletal Muscle+2.220.000
43CAPRIN2caprin family member 2Skeletal Muscle+2.200.007
44FRZBfrizzled-related proteinSkeletal Muscle+2.170.003
45SPAG17sperm associated antigen 17Skeletal Muscle+2.170.015
46RGS2regulator of G-protein signaling 2, 24kDaSkeletal Muscle+2.170.008
47SLC16A6solute carrier family 16, member 6Skeletal Muscle+2.140.003
48PNPLA3patatin-like phospholipase domain containing 3Skeletal Muscle+2.100.031
49CYTIPcytohesin 1 interacting proteinSkeletal Muscle+2.090.002
50MIR133BmicroRNA 133bSkeletal Muscle+2.090.008
51MDM2MDM2 oncogene, E3 ubiquitin protein ligaseSkeletal Muscle+2.080.035
52EPB41L3erythrocyte membrane protein band 4.1-like 3Skeletal Muscle+2.070.003
53GPD1glycerol-3-phosphate dehydrogenase 1 (soluble)Skeletal Muscle-2.070.002
54TGFB2transforming growth factor, beta 2Skeletal Muscle+2.060.005
55FAM13Cfamily with sequence similarity 13, member CSkeletal Muscle+2.060.010
56HMCN1hemicentin 1Skeletal Muscle+2.060.003
57TRIM63tripartite motif containing 63, E3 ubiquitin protein ligaseSkeletal Muscle-2.050.006
58PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1Skeletal Muscle-2.040.031
59RUNX1runt-related transcription factor 1Skeletal Muscle+2.040.036
60CALML6calmodulin-like 6Skeletal Muscle-2.000.029
61ARRDC2arrestin domain containing 2Skeletal Muscle-2.000.003
62ASB4ankyrin repeat and SOCS box containing 4Skeletal Muscle-1.990.019
63ARHGAP36Rho GTPase activating protein 36Skeletal Muscle+1.970.002
64TMEM136transmembrane protein 136Skeletal Muscle+1.960.028
65GRB10growth factor receptor-bound protein 10Skeletal Muscle-1.950.015
66TMEM159transmembrane protein 159Skeletal Muscle-1.940.027
67MYH3myosin, heavy chain 3, skeletal muscle, embryonicSkeletal Muscle+1.930.025
68RALGPS2Ral GEF with PH domain and SH3 binding motif 2Skeletal Muscle+1.930.006
69OSBPL6oxysterol binding protein-like 6Skeletal Muscle+1.920.014
70MYOZ3myozenin 3Skeletal Muscle-1.920.014
71ZNF254zinc finger protein 254Skeletal Muscle+1.920.028
72SNX7sorting nexin 7Skeletal Muscle+1.920.014
73MYOGmyogenin (myogenic factor 4)Skeletal Muscle+1.920.038
74SFRP4secreted frizzled-related protein 4Skeletal Muscle+1.880.040
75PLCE1phospholipase C, epsilon 1Skeletal Muscle+1.860.013
76CCDC80coiled-coil domain containing 80Skeletal Muscle+1.850.002
77REPS2RALBP1 associated Eps domain containing 2Skeletal Muscle+1.850.017
78NCAM1neural cell adhesion molecule 1Skeletal Muscle+1.820.023
79CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Skeletal Muscle+1.820.001
80S100A11S100 calcium binding protein A11Skeletal Muscle+1.820.024
81LMOD1leiomodin 1 (smooth muscle)Skeletal Muscle-1.810.023
82EZRezrinSkeletal Muscle+1.800.019
83TRIM55tripartite motif containing 55Skeletal Muscle+1.780.049
84HSPA4Lheat shock 70kDa protein 4-likeSkeletal Muscle+1.780.049
85GCAgrancalcin, EF-hand calcium binding proteinBlood+1.770.000
86ALDH1L1aldehyde dehydrogenase 1 family, member L1Skeletal Muscle-1.770.007
87DCLK1doublecortin-like kinase 1Skeletal Muscle+1.760.017
88MIR29CmicroRNA 29cSkeletal Muscle-1.760.016
89UBE2Wubiquitin-conjugating enzyme E2W (putative)Skeletal Muscle+1.750.011
90NR1D1nuclear receptor subfamily 1, group D, member 1Skeletal Muscle-1.750.001
91CHN1chimerin 1Skeletal Muscle+1.750.048
92ZNF83zinc finger protein 83Skeletal Muscle+1.750.025
93LRRN3leucine rich repeat neuronal 3Skeletal Muscle+1.740.008
94ZNF382zinc finger protein 382Skeletal Muscle+1.740.006
95CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Skeletal Muscle+1.730.029
96ZNF117zinc finger protein 117Skeletal Muscle+1.720.048
97PIP5K1Bphosphatidylinositol-4-phosphate 5-kinase, type I, betaSkeletal Muscle+1.710.042
98ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1Skeletal Muscle+1.700.042
99CHRNDcholinergic receptor, nicotinic, delta (muscle)Skeletal Muscle+1.690.026
100PCDHB14protocadherin beta 14Skeletal Muscle+1.690.009
101OGNosteoglycinSkeletal Muscle+1.680.028
102MIR206microRNA 206Skeletal Muscle+1.680.026
103AGBL3ATP/GTP binding protein-like 3Skeletal Muscle+1.670.004
104CIARTcircadian associated repressor of transcriptionSkeletal Muscle-1.650.001
105ABI3BPABI family, member 3 (NESH) binding proteinSkeletal Muscle+1.640.008
106PLEKHA2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2Skeletal Muscle+1.620.017
107SLC16A9solute carrier family 16, member 9Skeletal Muscle+1.620.006
108THBS4thrombospondin 4Skeletal Muscle+1.610.017
109SLC19A2solute carrier family 19 (thiamine transporter), member 2Skeletal Muscle-1.610.017
110ARHGAP24Rho GTPase activating protein 24Skeletal Muscle+1.610.039
111ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 1Skeletal Muscle-1.570.008
112LPHN2latrophilin 2Skeletal Muscle+1.560.026
113DENND2CDENN/MADD domain containing 2CSkeletal Muscle-1.540.026
114LOC100131826TSSP3028Skeletal Muscle+1.540.041
115RPS26ribosomal protein S26Blood+1.520.000
116MSS51MSS51 mitochondrial translational activatorSkeletal Muscle-1.520.035
117HOXC9homeobox C9Skeletal Muscle-1.510.003
118PCDHB15protocadherin beta 15Skeletal Muscle+1.500.040
119ANTXR2anthrax toxin receptor 2Skeletal Muscle+1.500.035
120LRRC14Bleucine rich repeat containing 14BSkeletal Muscle-1.490.032
121SRGAP2BSLIT-ROBO Rho GTPase activating protein 2BSkeletal Muscle+1.490.016
122COL21A1collagen, type XXI, alpha 1Skeletal Muscle+1.490.049
123ZNF521zinc finger protein 521Skeletal Muscle+1.490.036
124SLC7A6solute carrier family 7 (amino acid transporter light chain, y+L system), member 6Skeletal Muscle+1.480.023
125AHRaryl hydrocarbon receptorSkeletal Muscle+1.430.047
126FAT4FAT atypical cadherin 4Skeletal Muscle+1.400.027
127SRGAP2SLIT-ROBO Rho GTPase activating protein 2Skeletal Muscle+1.390.026
128EYA1eyes absent homolog 1 (Drosophila)Skeletal Muscle+1.380.022
129KLF15Kruppel-like factor 15Skeletal Muscle-1.370.038
130CCDC101coiled-coil domain containing 101Skeletal Muscle-1.350.036
131RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 6Skeletal Muscle+1.350.046
132CRY1cryptochrome circadian clock 1Skeletal Muscle+1.330.021
133DAAM2dishevelled associated activator of morphogenesis 2Skeletal Muscle-1.300.032
134S100A10S100 calcium binding protein A10Skeletal Muscle+1.290.046
135PRTGprotogeninSkeletal Muscle+1.280.048
136TUBB6tubulin, beta 6 class VBlood-1.240.000
137HSBP1heat shock factor binding protein 1Blood+1.160.000
138SAMD9Lsterile alpha motif domain containing 9-likeBlood+1.070.000
139GPR171G protein-coupled receptor 171Blood+1.060.000
140IRS2insulin receptor substrate 2Blood-1.030.000
141PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7)Blood+1.030.000
142RAB10RAB10, member RAS oncogene familyBlood+1.000.000

Expression patterns in normal tissues for genes affiliated with Amyotrophic Lateral Sclerosis

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis.

Pathways for genes affiliated with Amyotrophic Lateral Sclerosis

About this section

Pathways related to Amyotrophic Lateral Sclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.9ALS2, NEFH, SOD1

Compounds for genes affiliated with Amyotrophic Lateral Sclerosis

About this section

GO Terms for genes affiliated with Amyotrophic Lateral Sclerosis

About this section

Cellular components related to Amyotrophic Lateral Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.4TRAK2, NIF3L1, RAPH1, STRADB, NEFH, SOD1

Biological processes related to Amyotrophic Lateral Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of Rac GTPase activityGO:03231410.2ALS2, SOD1
2cell deathGO:0082199.1SIGMAR1, ALS2, NEFH, SETX, C9orf72, FUS

Products for genes affiliated with Amyotrophic Lateral Sclerosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Amyotrophic Lateral Sclerosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet