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MCID: AMY001
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Amyotrophic Lateral Sclerosis malady |
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7 drugs, 495 genes, 20 tissues, 1209 related diseases, 28 phenotypes, 881 articles, clinical trials, genetic tests.
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Sources: 30NIH Rare Diseases, 23MedlinePlus, 2CDC, 15GeneReviews, 17Genetics Home Reference, 44Wikipedia, 33OMIM, 22MalaCards See all sources Export this MalaCard |
MedlinePlus: Amyotrophic lateral sclerosis (als) is a nervous system disease that attacks nerve cells called neurons in your brain and spinal cord. these neurons transmit messages from your brain and spinal cord to your voluntary muscles - the ones you can control, like in your arms and legs. at first, this causes mild muscle problems. some people notice
trouble walking or running
trouble writing
speech problems
eventually, you lose your strength and cannot move. when muscles in your chest fail, you cannot breathe. a ventilator can help, but most people with als die from respiratory failure.
the disease usually strikes between age 40 and 60. more men than women get it. no one knows what causes als. it can run in families, but usually it strikes at random. there is no cure. medicines can relieve symptoms and, sometimes, prolong survival.
nih: national institute of neurological disorders and stroke23
MalaCards: Amyotrophic Lateral Sclerosis, also known as als, is related to neuronitis and amyotrophic lateral sclerosis (als). An important gene associated with Amyotrophic Lateral Sclerosis is SETX (senataxin), and among its related pathways are Amyotrophic lateral sclerosis (ALS) and Neuroscience. The drugs citalopram hydrobromide and citalopram and the compounds lipid and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are nervous system and behavior/neurological. NIH Rare Diseases: Amyotrophic lateral sclerosis (ALS), also referred to as "Lou Gehrig's disease" is a disease of the motor nerve cells in the brain and spinal cord. ALS is caused by progressive loss of motor nerves in these areas and affects approximately 1 out of 100,000 people. The diagnosis of ALS is usually based on clinical features, electrodiagnostic testing (EMG), and exclusion of other health conditions with related symptoms. Most people with amyotrophic lateral sclerosis have a form of the condition that is described as sporadic or noninherited. The cause of sporadic amyotrophic lateral sclerosis is largely unknown but probably involves a combination of genetic and environmental factors. About 10 percent of people with amyotrophic lateral sclerosis have a familial form of the condition, which is caused by an inherited genetic mutation.30 CDC: Welcome to ATSDR’s National Amyotrophic Lateral Sclerosis (ALS) Registry website. This site allows Persons with ALS (PALS) the opportunity to enroll in the National ALS Registry. We welcome visitor feedback as we continue to improve this site.2 NINDS: Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig's disease or classical motor neuron disease, is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells responsible for controlling voluntary muscles.31 Genetics Home Reference: Amyotrophic lateral sclerosis (ALS) is a progressive disease that affects motor neurons, which are specialized nerve cells that are important for controlling muscle movement and strength. These nerve cells are found in the spinal cord and the brain. In ALS, motor neurons die over time, leading to problems with muscle control and movement.17 Wikipedia: Amyotrophic lateral sclerosis (ALS)44 more... OMIM: 105400 GeneReviews summary for als-overview |
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Sources: 6Disease Ontology, 7diseasecard, 44Wikipedia, 15GeneReviews, 30NIH Rare Diseases, 16GeneTests, 17Genetics Home Reference, 31NINDS, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 2CDC, 43UMLS, 27NCIt, 24MeSH, 40SNOMED-CT, 19ICD9CM See all sources |
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Sources: 33OMIM See all sources |
Clinical features from OMIM: 105400
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for amyotrophic lateral sclerosis Drug clinical trials:Search ClinicalTrials for amyotrophic lateral sclerosis Search NIH Clinical Center for amyotrophic lateral sclerosis Search CenterWatch for amyotrophic lateral sclerosis Inferred drug relations via UMLS/NDF-RT:43 28 citalopram, citalopram hydrobromide, prochlorperazine, prochlorperazine edisylate, prochlorperazine maleate, riluzole, risperidoneCell-based therapeutics: The database of embryonic development, stem cell research and regenerative medicine Stem-Cell-Based therapeutic approaches for amyotrophic lateral sclerosis:
Embryonic/Adult Cultured Cells Related to amyotrophic lateral sclerosis:
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Sources: 16GeneTests See all sources |
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Sources: 21LifeMap Discovery™, 22MalaCards See all sources |
MalaCards organs/tissues related to amyotrophic lateral sclerosis:22Bone marrow, Whole blood, Brain, Cortex, Spinal cord, Smooth muscle, Skeletal muscle, Liver, Breast, Skin, Prostate, Monocytes, T cells, B cells, Endothelial, Temporal lobe, Pons, Pituitary The database of embryonic development, stem cell research and regenerative medicine Embryonic and adult cells/anatomical compartments related to amyotrophic lateral sclerosis:
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Spinal Cord -> Motor Neural Progenitor Domain -> |
Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to amyotrophic lateral sclerosis:25 (show all 28)
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Sources: 35PubMed See all sources |
Articles related to amyotrophic lateral sclerosis:(show top 50) (show all 881)
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Sources: 1BioGPS See all sources |
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Sources: 20KEGG, 3Cell Signaling Technology, 36QIAGEN, 37R&D Systems, 10EMD Millipore, 41Thomson Reuters See all sources |
Pathways related to amyotrophic lateral sclerosis according to GeneDecks:(show top 50) (show all 229)
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Sources: 32Novoseek , 42Tocris Bioscience, 18HMDB, 9DrugBank, 34PharmGKB See all sources |
Compounds related to amyotrophic lateral sclerosis according to GeneDecks:(show top 50) (show all 523)
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Sources: 12Gene Ontology See all sources |
Cellular components related to amyotrophic lateral sclerosis according to GeneDecks:(show all 21)
Biological processes related to amyotrophic lateral sclerosis according to GeneDecks:(show top 50) (show all 62)
Molecular functions related to amyotrophic lateral sclerosis according to GeneDecks:(show all 15)
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