MCID: AMY066
MIFTS: 27

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex malady

Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases categories

Aliases & Classifications for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources:
46OMIM, 9diseasecard, 42NIH Rare Diseases, 48Orphanet, 22GTR, 61UMLS, 26ICD10 via Orphanet
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Aliases & Descriptions for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

Name: Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 46
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 42 48 22
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia of Guam 42 48
Parkinsonism-Dementia-Als Complex 42 48
Lytico-Bodig Disease 42 48
Guam Disease 42 48
 
Pdals 42 48
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex, Susceptibility to 9
Amyotrophic Lateral Sclerosis, Parkinsonism/dementia Complex of Guam 42
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 42
Amyotrophic Lateral Sclerosis, Guam Form 61


Classifications:



External Ids:

OMIM46 105500
Orphanet48 90020
ICD10 via Orphanet26 G12.2

Summaries for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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OMIM:46 Amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam is a neurodengenerative disorder with unusually... (105500) more...

MalaCards based summary: Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex, also known as amyotrophic lateral sclerosis-parkinsonism-dementia complex, is related to dementia and lateral sclerosis, and has symptoms including dementia, bulbar palsy and parkinsonism. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex is TRPM7 (transient receptor potential cation channel, subfamily M, member 7). Related mouse phenotypes are growth/size/body and behavior/neurological.

Related Diseases for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Diseases related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1dementia31.6PARK7
2lateral sclerosis11.0
3tauopathy10.5
4rem sleep behavior disorder10.3
5alzheimer disease9.9PCSK1N, PARK7

Graphical network of diseases related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:



Diseases related to amyotrophic lateral sclerosis-parkinsonism/dementia complex

Symptoms for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Symptoms by clinical synopsis from OMIM:

105500

Clinical features from OMIM:

105500

HPO human phenotypes related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

(show all 7)
id Description Frequency HPO Source Accession
1 dementia HP:0000726
2 bulbar palsy HP:0001283
3 parkinsonism HP:0001300
4 muscle weakness HP:0001324
5 abnormality of the lower motor neuron HP:0002366
6 muscle cramps HP:0003394
7 amyotrophic lateral sclerosis HP:0007354

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Drug clinical trials:

Search ClinicalTrials for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Search NIH Clinical Center for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Genetic Tests for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Genetic tests related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

id Genetic test Affiliating Genes
1 Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex, Susceptibility to22

Anatomical Context for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Animal Models for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex or affiliated genes

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MGI Mouse Phenotypes related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.5TRPM7, PCSK1N, PARK7
2MP:00053868.2TRPM7, PCSK1N, PARK7

Publications for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Articles related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

idTitleAuthorsYear
1
C9orf72 hexanucleotide repeat expansion and Guam amyotrophic lateral sclerosis-Parkinsonism-dementia complex. (23588498)
2013
2
TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. (19405049)
2010
3
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC). (18843496)
2008
4
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. (18759352)
2008
5
Atypical parkinsonism of Japan: amyotrophic lateral sclerosis-parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease): an update. (16092099)
2005
6
Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. (12093078)
2002
7
Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes. (8834536)
1996
8
Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex. (8858002)
1996
9
Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins. (7717459)
1995

Variations for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Expression for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex.

Pathways for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Compounds for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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GO Terms for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet