PDALS
MCID: AMY066
MIFTS: 29

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex (PDALS) malady

Neuronal diseases, Rare diseases, Mental diseases categories

Summaries for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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OMIM:46 Amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam is a neurodengenerative disorder with unusually...105500 more...

MalaCards based summary: Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex, also known as guam disease, is related to dementia and amyotrophic lateral sclerosis, and has symptoms including dementia, bulbar palsy and parkinsonism. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex is TRPM7 (transient receptor potential cation channel, subfamily M, member 7). Related mouse phenotypes are growth/size/body and behavior/neurological.

Aliases & Classifications for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources:
46OMIM, 48Orphanet, 61UMLS, 27ICD10 via Orphanet
See all sources

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex, Aliases & Descriptions:

Name: Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 46
Guam Disease 48 61
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 48
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia of Guam 48
 
Parkinsonism-Dementia-Als Complex 48
Lytico-Bodig Disease 48
Pdals 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Mental diseases


External Ids:

OMIM46 105500
ICD10 via Orphanet27 G12.2

Related Diseases for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Diseases in the Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex family:

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1

Diseases related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1dementia31.6PARK7
2amyotrophic lateral sclerosis11.0
3lateral sclerosis11.0
4amyotrophic lateral sclerosis-parkinsonism/dementia complex 110.8
5tauopathy10.5
6rem sleep behavior disorder10.3
7alzheimer's disease9.9PCSK1N, PARK7

Graphical network of diseases related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:



Diseases related to amyotrophic lateral sclerosis-parkinsonism/dementia complex

Symptoms for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Symptoms by clinical synopsis from OMIM:

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Clinical features from OMIM:

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HPO human phenotypes related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

(show all 7)
id Description Frequency HPO Source Accession
1 dementia HP:0000726
2 bulbar palsy HP:0001283
3 parkinsonism HP:0001300
4 muscle weakness HP:0001324
5 abnormality of the lower motor neuron HP:0002366
6 muscle cramps HP:0003394
7 amyotrophic lateral sclerosis HP:0007354

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Drug clinical trials:

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Search NIH Clinical Center for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Genetic Tests for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Anatomical Context for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Animal Models for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex or affiliated genes

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MGI Mouse Phenotypes related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.5TRPM7, PCSK1N, PARK7
2MP:00053868.2TRPM7, PCSK1N, PARK7

Publications for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Articles related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

idTitleAuthorsYear
1
C9orf72 hexanucleotide repeat expansion and Guam amyotrophic lateral sclerosis-Parkinsonism-dementia complex. (23588498)
2013
2
TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. (19405049)
2010
3
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC). (18843496)
2008
4
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. (18759352)
2008
5
Atypical parkinsonism of Japan: amyotrophic lateral sclerosis-parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease): an update. (16092099)
2005
6
Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. (12093078)
2002
7
Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes. (8834536)
1996
8
Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex. (8858002)
1996
9
Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins. (7717459)
1995

Variations for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Expression for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Expression patterns in normal tissues for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Pathways for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Compounds for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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GO Terms for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Products for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet