PDALS
MCID: AMY066
MIFTS: 28

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex (PDALS) malady

Neuronal diseases, Rare diseases, Mental diseases categories

Summaries for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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48OMIM, 34MalaCards
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MalaCards: Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex, also known as amyotrophic lateral sclerosis-parkinsonism-dementia complex, is related to dementia and lateral sclerosis. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex is TRPM7 (transient receptor potential cation channel, subfamily M, member 7). Affiliated tissues include brain, and related mouse phenotypes are growth/size/body and behavior/neurological.

Description from OMIM:48 105500

Aliases & Classifications for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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48OMIM, 50Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Mental diseases


Aliases & Descriptions:

amyotrophic lateral sclerosis-parkinsonism/dementia complex 48
amyotrophic lateral sclerosis-parkinsonism-dementia complex 50
amyotrophic lateral sclerosis-parkinsonism-dementia of guam 50
parkinsonism-dementia-als complex 50
lytico-bodig disease 50
guam disease 50
pdals 50


External Ids:

OMIM48 105500
ICD10 via Orphanet27 G12.2, G31.0

Related Diseases for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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18GeneCards, 19GeneDecks
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Diseases in the Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex family:

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1

Diseases related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1dementia31.5PARK7
2lateral sclerosis11.0
3amyotrophic lateral sclerosis11.0
4amyotrophic lateral sclerosis-parkinsonism/dementia complex 110.7
5tauopathy10.5
6rem sleep behavior disorder10.3
7alzheimer's disease10.0PCSK1N, PARK7

Graphical network of diseases related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:



Diseases related to amyotrophic lateral sclerosis-parkinsonism/dementia complex

Symptoms for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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48OMIM
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Symptoms by clinical synopsis from OMIM:

105500

Clinical features from OMIM:

105500

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Drug clinical trials:

Search ClinicalTrials for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Search NIH Clinical Center for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Search CenterWatch for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Genetic Tests for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Anatomical Context for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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34MalaCards
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MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

34
Brain

Animal Models for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.5TRPM7, PCSK1N, PARK7
2MP:00053868.2TRPM7, PCSK1N, PARK7

Publications for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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53PubMed
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Articles related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

idTitleAuthorsYear
1
C9orf72 hexanucleotide repeat expansion and Guam amyotrophic lateral sclerosis-Parkinsonism-dementia complex. (23588498)
2013
2
TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. (19405049)
2010
3
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC). (18843496)
2008
4
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. (18759352)
2008
5
Atypical parkinsonism of Japan: amyotrophic lateral sclerosis-parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease): an update. (16092099)
2005
6
Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. (12093078)
2002
7
Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes. (8834536)
1996
8
Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex. (8858002)
1996
9
Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins. (7717459)
1995

Variations for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Expression for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex.

Pathways for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Compounds for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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GO Terms for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Products for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet