PDALS
MCID: AMY066
MIFTS: 44

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex (PDALS) malady

Neuronal diseases category

Summaries for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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46OMIM, 32MalaCards
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MalaCards: Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex, also known as amyotrophic lateral sclerosis-parkinsonism-dementia complex, is related to lateral sclerosis and amyotrophic lateral sclerosis. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex is TRPM7 (transient receptor potential cation channel, subfamily M, member 7), and among its related pathways are superoxide radicals degradation and Reelin Pathway (Cajal-Retzius cells). The compounds thioflavin t and dityrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are taste/olfaction and other.

Description from OMIM:46 105500

Aliases & Classifications for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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48Orphanet, 46OMIM, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

amyotrophic lateral sclerosis-parkinsonism/dementia complex 46
amyotrophic lateral sclerosis-parkinsonism-dementia complex 48
amyotrophic lateral sclerosis-parkinsonism-dementia of guam 48
parkinsonism-dementia-als complex 48
lytico-bodig disease 48
guam disease 48
pdals 48


External Ids:

OMIM46 105500
ICD10 via Orphanet26 G12.2, G31.0

Related Diseases for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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17GeneCards, 18GeneDecks
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Diseases in the Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex family:

Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1

Diseases related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1lateral sclerosis31.4SNCA, MAPT, ALS2
2amyotrophic lateral sclerosis31.3ALS2, TARDBP, MAPT, C9orf72, SYP, SNCA
3dementia31.3SNCA, APOE, APP, RPS27A, SYP, MAPT
4tauopathy30.6PARK2, PARK7, LRRK2, MAPT, SNCA, APP
5rem sleep behavior disorder30.3SNCA
6amyotrophic lateral sclerosis-parkinsonism/dementia complex 110.7
7sleep disorder10.2
8neuronal intranuclear inclusion disease10.0RPS27A
9infertility10.0RPS27A
10scrapie10.0MAPT
11neuroblastoma10.0SYP
12transient cerebral ischemia10.0RPS27A
13neuritis10.0SNCA
14hydrocephalus10.0MAPT
15dysautonomia10.0SNCA
16semantic dementia10.0RPS27A, MAPT
17pancreatitis10.0SOD2
18lrrk2-related parkinson disease10.0LRRK2
19primary progressive aphasia10.0RPS27A, MAPT
20vascular dementia10.0APOE
21melanoma10.0SOD2
22hypertension10.0APOE
23spinocerebellar ataxia type 310.0RPS27A, SNCA
24multiple sclerosis10.0APOE
25leukemia10.0PARK2
26ependymoma10.0SYP
27neuropathy10.0SOD2
28insulin resistance10.0SOD3, RPS27A
29neuroaxonal dystrophy10.0SNCA, RPS27A
30schizophrenia10.0SYP, SNCA
31striatonigral degeneration10.0RPS27A, SNCA
32aphasia10.0TARDBP, MAPT, C9orf72
33central neurocytoma10.0SNCA, SYP
34hereditary cerebral amyloid angiopathy10.0APP
35spinal muscular atrophy 110.0SYP, RPS27A
36pancreatic cancer10.0SOD2, RPS27A
37hyperhomocysteinemia10.0APOE, SOD3
38arthritis10.0SOD3, SOD2
39spinocerebellar ataxia10.0RPS27A, SNCA, MAPT
40encephalitis10.0APP
41hepatitis b10.0SOD2
42movement disease10.0LRRK2, SNCA
43brain ischemia10.0MAPT, APP
44hepatocellular carcinoma10.0PARK2, SOD2
45neuroaxonal dystrophy, infantile10.0RPS27A, APP
46ischemia10.0MAPT, SNCA, SOD2
47diabetes mellitus10.0SOD2, APOE
48medulloblastoma10.0SNCA, SYP
49lung cancer10.0APP, SYP
50inclusion body myositis10.0MAPT, APP, RPS27A

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:



Diseases related to amyotrophic lateral sclerosis-parkinsonism/dementia complex

Clinical Features for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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46OMIM
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Clinical features from OMIM:

105500

Clinical synopsis from OMIM:

105500

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Drug clinical trials:

Search ClinicalTrials for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Search NIH Clinical Center for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Search CenterWatch for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Genetic Tests for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Anatomical Context for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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32MalaCards
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MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

32
Brain

Animal Models for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.1SNCA
2MP:00053958.5SOD2, APP, APOE, MAPT
3MP:00107717.9LRRK2, PARK2, MAPT, APP, SOD2
4MP:00053697.2SOD2, APP, APOE, MAPT, PARK2, ALS2
5MP:00030127.1PARK2, LRRK2, TARDBP, MAPT, SYP, SNCA
6MP:00053877.1LRRK2, SOD2, APP, SNCA, TRPM7, MAPT
7MP:00053846.5SOD2, APP, PARK2, LRRK2, TARDBP, MAPT
8MP:00036316.4APOE, SOD2, APP, ALS2, PARK2, PARK7
9MP:00053766.2APP, SOD3, SNCA, TARDBP, LRRK2, PARK7
10MP:00053786.2ALS2, SOD2, PARK2, APP, PARK7, TARDBP
11MP:00107686.1PARK2, APOE, ALS2, LRRK2, TARDBP, MAPT
12MP:00053865.9ALS2, APP, APOE, MAPT, PCSK1N, TARDBP

Publications for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Genetic Variations for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Expression for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex.

Pathways for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG, 4Cell Signaling Technology
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Pathways related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SOD2, SOD3
29.1MAPT, APOE, APP
39.1APP, APOE, MAPT
49.0PARK2, PARK7, SNCA
58.6SNCA, LRRK2, PARK7, PARK2
6
Hide members
8.6RPS27A, SNCA, MAPT, PARK7, PARK2
7
Hide members
6.8SOD2, APP, APOE, SNCA, MAPT, LRRK2
86.6PARK2, APP, APOE, SNCA, SYP, MAPT

Compounds for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1thioflavin t449.8APP, SNCA
2dityrosine449.8SNCA, SOD2
3thioflavin449.7MAPT, SNCA, APP
4silver449.6RPS27A, SNCA, SYP, MAPT
5tacrine44 1110.4APP, APOE, MAPT
6donepezil44 11 2411.4MAPT, APOE, APP
7methamphetamine44 49 1111.4SNCA, SOD2, RPS27A
8galantamine44 49 1111.4MAPT, APOE, APP
9heparin44 28 11 2412.3SOD3, APP, SNCA, MAPT
10guanidine hydrochloride449.2RPS27A, SOD2, APOE, SNCA
11formaldehyde44 2410.2RPS27A, APP, SYP, MAPT
12alpha tocopherol449.1SOD3, SOD2, APOE, SNCA
13choline44 11 2411.1APP, SNCA, SYP, MAPT
14mg 13244 5910.0PARK2, MAPT, SNCA, RPS27A
15mptp449.0PARK2, SNCA, SOD2, RPS27A
16copper44 249.9SNCA, APP, SOD2, SOD3
17chloroquine44 2 49 28 1112.9RPS27A, APP, APOE, SYP, MAPT
18thioflavine s448.9MAPT, SNCA, APOE, APP, RPS27A
19h2o2448.9RPS27A, SNCA, SYP, MAPT, PARK2
20formate448.9RPS27A, APP, APOE, SNCA, MAPT
21carbon448.9RPS27A, SOD2, APP, SYP
22sodium dodecylsulfate448.9RPS27A, APP, APOE, SNCA, MAPT
23levodopa44 119.8RPS27A, SNCA, LRRK2, PARK7, PARK2
24serine448.8MAPT, TRPM7, SYP, SNCA, APP, SOD3
25rotenone448.8RPS27A, SOD2, SNCA, PARK7, PARK2
26n acetylcysteine448.8RPS27A, SOD3, SOD2, APOE, SNCA, MAPT
27folate448.7SOD3, SOD2, APP, APOE, MAPT
28glycogen44 249.7PARK2, MAPT, SYP, SNCA, RPS27A
29paraffin448.7MAPT, SYP, SNCA, APOE, SOD2, RPS27A
30actinomycin d448.6RPS27A, SOD2, APP, APOE, MAPT
314-hydroxynonenal44 249.4RPS27A, SOD2, APP, APOE, SNCA, MAPT
32valine448.4RPS27A, SOD2, APP, APOE, SNCA, MAPT
33cyclosporin a44 28 5910.4RPS27A, SOD2, APP, APOE, MAPT
34creatinine448.4RPS27A, SOD2, APP, APOE, SYP, MAPT
35guanine44 11 2410.2RPS27A, SOD2, APOE, SYP, PARK2, ALS2
366-hydroxydopamine448.2RPS27A, SOD2, APP, SNCA, PARK7, PARK2
37superoxide44 249.1SOD3, SOD2, SYP, TARDBP, PARK7, PARK2
38nmda44 289.1RPS27A, APP, APOE, SYP, MAPT, PARK2
39lactacystin448.1RPS27A, APP, APOE, SNCA, MAPT, PARK2
40arginine448.1RPS27A, SOD3, SOD2, APP, APOE, SNCA
41acetylcholine44 49 28 11 2411.9RPS27A, SOD3, SOD2, APP, APOE, SNCA
42glutamate447.8RPS27A, APP, APOE, SNCA, SYP, MAPT
43iron44 248.8SOD3, SOD2, APP, SNCA, PARK2
44vegf447.6RPS27A, SOD3, SOD2, APP, APOE, SYP
45alanine447.3RPS27A, SOD3, SOD2, APP, APOE, SNCA
46glutamine447.3RPS27A, SOD2, APP, APOE, SNCA, SYP
47testosterone44 59 11 2410.1RPS27A, SOD2, APP, APOE, SNCA, SYP
48lipid447.0SOD3, SOD2, APP, APOE, SNCA, SYP
49cysteine446.8RPS27A, SOD3, SOD2, APP, APOE, SNCA
50dopamine44 28 11 249.7APOE, APP, SOD2, RPS27A, SNCA, SYP

GO Terms for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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16Gene Ontology
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Cellular components related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:0304269.5SNCA, MAPT, ALS2
2trans-Golgi networkGO:0058029.3LRRK2, PCSK1N, SOD3
3axonGO:0304249.0ALS2, MAPT, SNCA, APP
4mitochondrionGO:0057397.8SOD3, SOD2, SNCA, LRRK2, PARK7, PARK2
5Golgi apparatusGO:0057947.3APP, APOE, SNCA, PCSK1N, PARK2

Biological processes related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dopamine uptake involved in synaptic transmissionGO:05158310.1PARK7, SNCA
2regulation of locomotionGO:0400129.9LRRK2, SNCA
3removal of superoxide radicalsGO:0194309.8SOD3, SOD2
4regulation of long-term neuronal synaptic plasticityGO:0481699.8SYP, SNCA
5axon cargo transportGO:0080889.8APP, MAPT
6response to dietary excessGO:0020219.6APOE, PCSK1N
7positive regulation of axon extensionGO:0457739.6MAPT, APOE
8adult locomotory behaviorGO:0083449.5APP, SNCA, PARK7
9neuron deathGO:0709979.5LRRK2, PARK2
10positive regulation of protein serine/threonine kinase activityGO:0719029.5ALS2, SNCA
11regulation of autophagyGO:0105069.4PARK2, MAPT
12locomotory behaviorGO:0076269.2ALS2, APP, SOD2
13response to oxidative stressGO:0069799.2ALS2, LRRK2, APP
14negative regulation of neuron apoptotic processGO:0435248.4SOD2, APOE, SNCA, PARK7, PARK2
15cell deathGO:0082198.0ALS2, PARK2, PARK7, TARDBP, TRPM7, C9orf72

Molecular functions related to Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.7APOE, MAPT
2superoxide dismutase activityGO:0047849.7SOD3, SOD2
3tau protein bindingGO:0481569.3SNCA, APOE
4heparin bindingGO:0082019.1APOE, APP, SOD3
5identical protein bindingGO:0428026.7PARK2, SOD2, APP, APOE, SNCA, SYP

Products for genes affiliated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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Sources for Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet