Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 2 malady

MalaCards: Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 2, also known as amyotrophic lateral sclerosis, is related to amyotrophic lateral sclerosis (als) and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. An important gene associated with Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 2 is PARK7 (parkinson protein 7). The drug riluzole has been mentioned in the context of this disorder.

amyotrophic lateral sclerosis-parkinsonism/dementia complex 2 33 amyotrophic lateral sclerosis 43

Disease types for amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 family:

amyotrophic lateral sclerosis-parkinsonism/dementia complex 2

Diseases related to amyotrophic lateral sclerosis-parkinsonism/dementia complex 2 by text searches and GeneDecks gene sharing:

(show top 50)    (show all 75)

id	Related Disease	Score	Top Affiliating Genes
1	amyotrophic lateral sclerosis (als)	12.2
2	amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	10.7
3	motor neuron disease	10.3
4	amyotrophic lateral sclerosis with frontotemporal dementia	10.2
5	amyotrophic lateral sclerosis, type 4	9.9
6	amyotrophic lateral sclerosis type 2	9.9
7	amyotrophic lateral sclerosis type 8	9.5
8	setx-related amyotrophic lateral sclerosis	9.5
9	tardbp-related amyotrophic lateral sclerosis	9.5
10	fig4-related amyotrophic lateral sclerosis	9.3
11	neurodegenerative disease	9.3
12	amyotrophic lateral sclerosis type 11	9.3
13	amyotrophic lateral sclerosis type 3	9.3
14	amyotrophic lateral sclerosis type 7	9.3
15	amyotrophic lateral sclerosis type 9	9.3
16	amyotrophic lateral sclerosis type 10	9.0
17	amyotrophic lateral sclerosis type 5	9.0
18	amyotrophic lateral sclerosis type 6	9.0
19	muscular atrophy	9.0
20	ubqln2-related amyotrophic lateral sclerosis/frontotemporal dementia	9.0
21	vapb-related amyotrophic lateral sclerosis	9.0
22	autosomal recessive juvenile amyotrophic lateral sclerosis	8.6
23	blindness	8.6
24	c9orf72-related amyotrophic lateral sclerosis/frontotemporal dementia	8.6
25	fus-related amyotrophic lateral sclerosis	8.6
26	neuropathy	8.6
27	optn-related amyotrophic lateral sclerosis	8.6
28	pfn1-related amyotrophic lateral sclerosis	8.6
29	sod1-related amyotrophic lateral sclerosis	8.6
30	spinal muscular atrophy	8.6
31	amyotrophic lateral sclerosis multi-gene panels	8.6
32	vcp-related amyotrophic lateral sclerosis/frontotemporal dementia	8.6
33	amyotrophic lateral sclerosis-5, juvenile recessive	8.6
34	amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia	8.6
35	amyotrophic lateral sclerosis 10, with or without ftd	8.6
36	amyotrophic lateral sclerosis, due to sod1 deficiency	8.6
37	amyotrophic lateral sclerosis, chmp2b-related	8.6
38	ang-related amyotrophic lateral sclerosis	8.6
39	leukemia	8.1
40	multiple system atrophy	8.1
41	poliomyelitis	8.1
42	werdnig-hoffmann disease	8.1
43	cervicitis	8.1
44	down syndrome	8.1
45	foot drop	8.1
46	hereditary neuropathies	8.1
47	hypoxia	8.1
48	inclusion body myopathy with early-onset paget disease and frontotemporal dementia	8.1
49	hemochromatosis	7.2
50	postpoliomyelitis syndrome	7.2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 riluzole

Genes related to amyotrophic lateral sclerosis-parkinsonism/dementia complex 2 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PARK7	parkinson protein 7	11.1	Disorders