MCID: AMY019
MIFTS: 31

Amyotrophic Lateral Sclerosis Type 10 malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Amyotrophic Lateral Sclerosis Type 10

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Aliases & Descriptions for Amyotrophic Lateral Sclerosis Type 10:

Name: Amyotrophic Lateral Sclerosis Type 10 11 46 13
Amyotrophic Lateral Sclerosis 10 11 46 25 66
Als10 11 46
 
Amyotrophic Lateral Sclerosis 10, with or Without Frontotemporal Dementia 11
Tardbp-Related Frontotemporal Lobar Degeneration with Tdp43 Inclusions 11

Classifications:



External Ids:

Disease Ontology11 DOID:0060201

Summaries for Amyotrophic Lateral Sclerosis Type 10

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Disease Ontology:11 A type of als caused by mutation located in tardbp gene located in chromosome 1.

MalaCards based summary: Amyotrophic Lateral Sclerosis Type 10, also known as amyotrophic lateral sclerosis 10, is related to amyotrophic lateral sclerosis 10, with or without ftd and subdural empyema. An important gene associated with Amyotrophic Lateral Sclerosis Type 10 is TARDBP (TAR DNA Binding Protein). Affiliated tissues include tardbp gene and testes.

Related Diseases for Amyotrophic Lateral Sclerosis Type 10

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Diseases in the Juvenile Amyotrophic Lateral Sclerosis family:

Amyotrophic Lateral Sclerosis 2, Juvenile Amyotrophic Lateral Sclerosis 19
Amyotrophic Lateral Sclerosis 17 Amyotrophic Lateral Sclerosis 21
Amyotrophic Lateral Sclerosis 11 Amyotrophic Lateral Sclerosis 16, Juvenile
Amyotrophic Lateral Sclerosis 4, Juvenile Amyotrophic Lateral Sclerosis 12
Amyotrophic Lateral Sclerosis 20 Amyotrophic Lateral Sclerosis 9
Amyotrophic Lateral Sclerosis 5, Juvenile Amyotrophic Lateral Sclerosis 18
Amyotrophic Lateral Sclerosis 3 Amyotrophic Lateral Sclerosis 7
Amyotrophic Lateral Sclerosis 8 Amyotrophic Lateral Sclerosis 1
Amyotrophic Lateral Sclerosis Type 2 Amyotrophic Lateral Sclerosis Type 4
Amyotrophic Lateral Sclerosis Type 5 Amyotrophic Lateral Sclerosis Type 6
amyotrophic lateral sclerosis type 10 Amyotrophic Lateral Sclerosis Type 14
Amyotrophic Lateral Sclerosis Type 15 Amyotrophic Lateral Sclerosis Type 16
Tardbp-Related Amyotrophic Lateral Sclerosis Als5-Related Amyotrophic Lateral Sclerosis
Erbb4-Related Amyotrophic Lateral Sclerosis Hnrnpa1-Related Amyotrophic Lateral Sclerosis
Ang-Related Amyotrophic Lateral Sclerosis Autosomal Recessive Juvenile Amyotrophic Lateral Sclerosis
Fig4-Related Amyotrophic Lateral Sclerosis Fus-Related Amyotrophic Lateral Sclerosis
Optn-Related Amyotrophic Lateral Sclerosis Pfn1-Related Amyotrophic Lateral Sclerosis
Setx-Related Amyotrophic Lateral Sclerosis Sigmar1-Related Amyotrophic Lateral Sclerosis
Sod1-Related Amyotrophic Lateral Sclerosis Vapb-Related Amyotrophic Lateral Sclerosis

Diseases related to Amyotrophic Lateral Sclerosis Type 10 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
idRelated DiseaseScoreTop Affiliating Genes
1amyotrophic lateral sclerosis 10, with or without ftd11.0
2subdural empyema10.3FUS, TARDBP
3osteogenesis imperfecta, type vi10.3FUS, TARDBP
4arthrogryposis, lethal, with anterior horn cell disease10.3FUS, TARDBP
5retrograde amnesia10.2FUS, TARDBP
6fetal alcohol spectrum disorder10.2ALS2, TARDBP
7breast adenoid cystic carcinoma10.2FUS, TARDBP
8nasal cavity inverting papilloma10.1FUS, TARDBP
9balo concentric sclerosis10.1FUS, TARDBP
10angiomyolipoma10.0FUS, TARDBP
11mast syndrome10.0ALS2, TARDBP
12colon kaposi sarcoma10.0FUS, RBM8A, TARDBP
13pick disease9.9FUS, RBM8A, TARDBP
14dementia, frontotemporal9.9
15amyotrophic lateral sclerosis 19.9
16frontotemporal lobar degeneration with ubiquitin-positive inclusions9.9
17anal sphincter dysplasia9.9ALS2, FUS
18renal tuberculosis9.7OPTN, SAMHD1
19tendinopathy9.7FUS, TARDBP
20trochlear nerve neoplasm9.7OPTN, SAMHD1
21mucopolysaccharidosis iii9.6ALS2, OPTN, TARDBP
22amyotrophic lateral sclerosis type 169.5FUS, OPTN, TARDBP
23neuromyotonia and axonal neuropathy, autosomal recessive9.5FUS, OPTN, TARDBP
24chronic intestinal vascular insufficiency9.5FUS, OPTN, TARDBP
25atrophy of prostate8.1ALS2, ANG, FIG4, FUS, OPTN, TARDBP
26yunis-varon syndrome7.8ALS2, ANG, DAO, FIG4, FUS, OPTN
27specific granule deficiency7.8ALS2, ANG, DAO, FIG4, FUS, OPTN
28retinitis pigmentosa 467.8ALS2, ANG, DAO, FIG4, FUS, OPTN
29amyotrophic lateral sclerosis type 147.8ALS2, ANG, DAO, FIG4, FUS, OPTN
30long qt syndrome 57.4ALS2, ANG, DAO, FIG4, FUS, OPTN
31amyotrophic lateral sclerosis type 156.9ALS2, ANG, DAO, FIG4, FUS, OPTN

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis Type 10:



Diseases related to amyotrophic lateral sclerosis type 10

Symptoms for Amyotrophic Lateral Sclerosis Type 10

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Drugs & Therapeutics for Amyotrophic Lateral Sclerosis Type 10

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Drugs for Amyotrophic Lateral Sclerosis Type 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tauroursodeoxycholic acidPhase 21214605-22-212443252
Synonyms:
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl) amino)ethanesulfonate
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl) amino)ethanesulfonic acid
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)-Ethanesulfonate
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)-Ethanesulfonic acid
3a,7b-Dihydroxy-5b-cholanoyltaurine
 
N-(3-alpha,7-beta-Dihydroxy-5-beta-cholan-24-oyl)-Taurine
TUDCA
Tauroursodeoxycholate
Tauroursodeoxycholic acid
Tauroursodesoxycholic acid
UR 906
Ursodeoxycholyltaurine
2
Ursodeoxycholic acidPhase 283128-13-231401
Synonyms:
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oate
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid
(3a,5b,7b)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid
(3α,5β,7β)-3,7-dihydroxycholan-24-oic acid
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
128-13-2
17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol
3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid
3,7-Dihydroxycholan-24-oic acid
3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid
3-alpha,7-beta-Dihydroxycholanic acid
3-alpha,7-beta-Dioxycholanic acid
3a,7b-Dihydroxy-5b-cholan-24-oate
3a,7b-Dihydroxy-5b-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholanic acid
4-10-00-01604 (Beilstein Handbook Reference)
50809-41-1
5beta-Cholan-24-oic acid-3alpha,7beta-diol
5beta-Cholanic Acid-3alpha,7beta-diol
7-beta-Hydroxylithocholic acid
7beta-Hydroxylithocholic acid
80225-86-1
AB00513977
AC-18919
AC-2081
AC1L1LJH
Acide ursodesoxycholique
Acide ursodesoxycholique [INN-French]
Acido ursodeossicolico
Acido ursodeossicolico [Italian]
Acido ursodeoxicolico
Acido ursodeoxicolico [INN-Spanish]
Acidum ursodeoxycholicum
Acidum ursodeoxycholicum [INN-Latin]
Actigall
Actigall (TN)
Antigall
Arsacol
BB_NC-2372
BPBio1_001052
BRN 3219888
BSPBio_000956
C07880
C24H40O4
CCRIS 5502
CHEBI:9907
CHEMBL1551
CHEMBL73390
CID11516715
CID31401
CPD-10534
CPD000058403
Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)- (9CI)
Cholit-ursan
D00734
DB01586
Delursan
Deoxyursocholic Acid
Destolit
Deursil
Dom-ursodiol c
EINECS 204-879-3
HMS1570P18
 
ISO-URSODEOXYCHOLIC ACID
IU5
LMST04010033
LS-53033
Litursol
Lyeton
MLS000028461
MLS001066373
MolPort-001-794-630
MolPort-005-932-884
NCGC00179363-01
NCI60_028904
NSC 657950
NSC 683769
PHL-ursodiol c
PMS-ursodiol c
Peptarom
Prestwick0_000958
Prestwick1_000958
Prestwick2_000958
Prestwick3_000958
S1643_Selleck
SAM002264653
SMP2_000012
SMR000058403
SPBio_003105
Sodium Ursodeoxycholate
Solutrat
U-9000
U0030
U5127_SIGMA
UDCA
UDCS
UNII-724L30Y2QR
URSODEOXYCHOLIC ACID
UrSO
Urosdesoxycholate
Urosdesoxycholic acid
Urosiol
Ursacholic Acid
Ursacol
Urso
Urso (TN)
Urso 250
Urso DS
Urso Forte
Ursobilin
Ursochol
Ursodamor
Ursodeoxy cholic acid
Ursodeoxycholate
Ursodeoxycholic acid
Ursodeoxycholic acid (JP15/INN)
Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol
Ursodeoxycholicacid
Ursodesoxycholic acid
Ursodexycholate
Ursodexycholic Acid
Ursodexycholic acid
Ursodiol
Ursodiol (USP)
Ursodiol [USAN]
Ursofalk
Ursolvan
Ursosan
chenodeoxycholic acid
ursodeoxycholate
ursodiol
3
Menthol21842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral SclerosisCompletedNCT00877604Phase 2
2Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS)CompletedNCT01504009
3Relationship Between Respiratory Functional Tests and Image Thoracic Techniques in Patients With Neuromuscular DiseasesCompletedNCT01090674

Search NIH Clinical Center for Amyotrophic Lateral Sclerosis Type 10

Genetic Tests for Amyotrophic Lateral Sclerosis Type 10

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Genetic tests related to Amyotrophic Lateral Sclerosis Type 10:

id Genetic test Affiliating Genes
1 Amyotrophic Lateral Sclerosis Type 1025

Anatomical Context for Amyotrophic Lateral Sclerosis Type 10

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MalaCards organs/tissues related to Amyotrophic Lateral Sclerosis Type 10:

34
Testes

FMA organs/tissues related to Amyotrophic Lateral Sclerosis Type 10:

17
Tardbp gene

Animal Models for Amyotrophic Lateral Sclerosis Type 10 or affiliated genes

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Publications for Amyotrophic Lateral Sclerosis Type 10

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Variations for Amyotrophic Lateral Sclerosis Type 10

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Clinvar genetic disease variations for Amyotrophic Lateral Sclerosis Type 10:

5
id Gene Variation Type Significance SNP ID Assembly Location
1TARDBPNM_007375.3(TARDBP): c.1144G> A (p.Ala382Thr)single nucleotide variantPathogenicrs367543041GRCh37Chr 1, 11082610: 11082610
2TARDBPNM_007375.3(TARDBP): c.*697G> Asingle nucleotide variantPathogenicrs387906334GRCh37Chr 1, 11083408: 11083408

Expression for genes affiliated with Amyotrophic Lateral Sclerosis Type 10

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Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis Type 10.

Pathways for genes affiliated with Amyotrophic Lateral Sclerosis Type 10

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GO Terms for genes affiliated with Amyotrophic Lateral Sclerosis Type 10

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Cellular components related to Amyotrophic Lateral Sclerosis Type 10 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:00304258.8ALS2, FUS, RBM8A
2neuronal cell bodyGO:00430258.5ALS2, ANG, FUS, RBM8A

Biological processes related to Amyotrophic Lateral Sclerosis Type 10 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:00076269.6ALS2, FIG4
2cell deathGO:00082199.4ALS2, OPTN

Molecular functions related to Amyotrophic Lateral Sclerosis Type 10 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:00001669.8FUS, RBM8A, TARDBP
2RNA bindingGO:00037239.2FUS, RBM8A, SAMHD1, TARDBP
3protein bindingGO:00055156.1ALS2, ANG, DAO, FIG4, FUS, OPTN

Sources for Amyotrophic Lateral Sclerosis Type 10

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet