MCID: AMY006
MIFTS: 32

Amyotrophic Lateral Sclerosis with Frontotemporal Dementia malady

Neuronal category

Summaries for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Amyotrophic Lateral Sclerosis with Frontotemporal Dementia, also known as amyotrophic lateral sclerosis and/or frontotemporal dementia 1, is related to lateral sclerosis and frontotemporal dementia. An important gene associated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia is C9orf72 (chromosome 9 open reading frame 72). The compounds dicoumarol and 6-hydroxydopamine have been mentioned in the context of this disorder.

Description from OMIM:47 105550,608030,612069

Aliases & Classifications for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
20GeneTests, 22GTR, 47OMIM, 49Orphanet, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
frontotemporal dementia with amyotrophic lateral sclerosis:
Inheritance: Autosomal dominant; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

amyotrophic lateral sclerosis with frontotemporal dementia 20 22
amyotrophic lateral sclerosis and/or frontotemporal dementia 1 61
amyotrophic lateral sclerosis and/or frontotemporal dementia 47
frontotemporal dementia with amyotrophic lateral sclerosis 49
frontotemporal dementia with motor neuron disease 49
frontotemporal dementia 61
ftd-mnd 49
ftd-als 49


External Ids:

Related Diseases for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the amyotrophic lateral sclerosis family:

amyotrophic lateral sclerosis type 8 amyotrophic lateral sclerosis, type 4
amyotrophic lateral sclerosis type 2 amyotrophic lateral sclerosis type 10
amyotrophic lateral sclerosis type 11 amyotrophic lateral sclerosis type 3
amyotrophic lateral sclerosis type 5 amyotrophic lateral sclerosis type 6
amyotrophic lateral sclerosis type 7 amyotrophic lateral sclerosis type 9
amyotrophic lateral sclerosis with frontotemporal dementia amyotrophic lateral sclerosis 10, with or without ftd
amyotrophic lateral sclerosis 2, juvenile amyotrophic lateral sclerosis 19
amyotrophic lateral sclerosis 17 amyotrophic lateral sclerosis 16, juvenile
amyotrophic lateral sclerosis 14, with or without frontotemporal dementia amyotrophic lateral sclerosis 4, juvenile
amyotrophic lateral sclerosis 12 amyotrophic lateral sclerosis 20
amyotrophic lateral sclerosis 13 amyotrophic lateral sclerosis 5, juvenile recessive
amyotrophic lateral sclerosis 18 amyotrophic lateral sclerosis 15, with or without frontotemporal dementia

Diseases related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1lateral sclerosis31.1TARDBP
2frontotemporal dementia31.1FUS, RPS27A, SOD1, UBQLN2, C9orf72, GRN
3amyotrophic lateral sclerosis31.1RPS27A, SOD1, UBQLN2, C9orf72, GRN, TARDBP
4aphasia31.1FUS, TARDBP, GRN, C9orf72
5semantic dementia31.1GRN, RPS27A
6primary progressive aphasia31.0GRN, RPS27A
7progressive supranuclear palsy31.0GRN, TARDBP, FUS
8pick's disease30.8TARDBP, RPS27A
9parkinson's disease30.7RPS27A
10alzheimer's disease30.6RPS27A, SOD1, GRN, TARDBP
11tauopathy30.6GRN, RPS27A
12frontotemporal lobar degeneration with ubiquitin-positive inclusions30.1GRN
13alcohol abuse30.1RPS27A
14inclusion body myopathy with early-onset paget disease and frontotemporal dementia10.8
15grn-related frontotemporal dementia10.7
16corticobasal degeneration10.7
17frontotemporal dementia, ubiquitin-positive10.6
18frontotemporal dementia with parkinsonism-1710.6
19chmp2b-related frontotemporal dementia10.6
20frontotemporal dementia, chromosome 3-linked10.5
21pathological gambling10.5
22bipolar disorder10.4
23brain disease10.4
24lewy body dementia10.4
25intracranial hypotension10.4
26n syndrome10.4
27inclusion body myopathy with paget disease of bone and/or frontotemporal dementia10.4
28inclusion body myopathy with early-onset paget disease and frontotemporal dementia 110.4
29amyotrophic lateral sclerosis 14, with or without frontotemporal dementia10.4
30vascular dementia10.3
31tardbp-related frontotemporal dementia10.3
32inclusion body myopathy wtih early-onset paget disease without frontotemporal dementia 310.3
33mills syndrome10.3
34adult syndrome10.2
35vascular disease10.2
36neuronal intranuclear inclusion disease10.2
37alzheimer disease risk factor10.2
38vcp-related amyotrophic lateral sclerosis/frontotemporal dementia10.2
39c9orf72-related amyotrophic lateral sclerosis/frontotemporal dementia10.2
40ubqln2-related amyotrophic lateral sclerosis/frontotemporal dementia10.2
41cerebral atrophy10.2
42dementia, familial, nonspecific10.2
43inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 210.2
44memory impairment10.2
45amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia10.2
46amyotrophic lateral sclerosis 15, with or without frontotemporal dementia10.2
47argyrophilic grain disease10.2
48major depressive disorder10.1
49narcissistic personality disorder10.1
50normal pressure hydrocephalus10.1

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia:



Diseases related to amyotrophic lateral sclerosis with frontotemporal dementia

Clinical Features for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

105550,608030,612069

Clinical synopsis from OMIM:

105550

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Drug clinical trials:

Search ClinicalTrials for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Search NIH Clinical Center for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Search CenterWatch for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Genetic Tests for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia:

id Genetic test Affiliating Genes
1 Amyotrophic Lateral Sclerosis With Frontotemporal Dementia20
2 Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis22

Anatomical Context for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Animal Models for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Genetic Variations for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Expression for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia.

Pathways for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Compounds for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
45Novoseek
See all sources

Compounds related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dicoumarol459.1SOD1, RPS27A
26-hydroxydopamine459.1SOD1, RPS27A
3formate459.0SOD1, RPS27A
4rotenone458.8SOD1, RPS27A

GO Terms for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Sources:
16Gene Ontology
See all sources

Biological processes related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:0075669.0GRN, SOD1
2cell deathGO:0082197.4FUS, TARDBP, PFN1, GRN, C9orf72, UBQLN2

Products for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet