Amyotrophic Lateral Sclerosis with Frontotemporal Dementia malady

MalaCards: Amyotrophic Lateral Sclerosis with Frontotemporal Dementia, also known as amyotrophic lateral sclerosis and/or frontotemporal dementia 1, is related to amyotrophic lateral sclerosis (als) and neuronitis. An important gene associated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia is C9orf72 (chromosome 9 open reading frame 72). The drug riluzole and the compounds dicoumarol and formate have been mentioned in the context of this disorder.

amyotrophic lateral sclerosis with frontotemporal dementia 7 16 amyotrophic lateral sclerosis and/or frontotemporal dementia 1 43

amyotrophic lateral sclerosis 43 alsftd 16

Diseases related to amyotrophic lateral sclerosis with frontotemporal dementia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 123)

id	Related Disease	Score	Top Affiliating Genes
1	amyotrophic lateral sclerosis (als)	37.0	TARDBP, SOD1
2	neuronitis	35.5	TARDBP, RPS27A, C9orf72, SOD1, GRN
3	motor neuron disease	32.6	TARDBP, GRN, RPS27A, SOD1
4	neurodegeneration	31.7	GRN, RPS27A, TARDBP, SOD1
5	muscular atrophy	31.3	RPS27A, TARDBP, SOD1
6	frontotemporal dementia	31.1	SOD1, TARDBP, C9orf72, GRN, RPS27A
7	amyotrophic lateral sclerosis	31.1	TARDBP, SOD1, RPS27A, GRN, C9orf72
8	lateral sclerosis	31.1	TARDBP, SOD1, C9orf72, GRN, RPS27A
9	dementia	31.1	TARDBP, C9orf72, RPS27A, SOD1, GRN
10	neurodegenerative disease	31.0	SOD1, TARDBP, GRN, RPS27A
11	tauopathy	30.9	GRN, RPS27A
12	alzheimer's disease	30.7	C9orf72, TARDBP, SOD1, RPS27A, GRN
13	parkinson's disease	30.5	GRN, TARDBP, RPS27A, SOD1
14	down syndrome	29.8	RPS27A, SOD1, TARDBP
15	chorea	29.3	TARDBP, RPS27A
16	spasticity	28.6	RPS27A, SOD1, TARDBP
17	paralysis	28.0	SOD1, RPS27A, C9orf72, TARDBP
18	estrogen-receptor negative breast cancer	12.8	SOD1, GRN
19	perry syndrome	12.8	GRN, TARDBP
20	primary progressive aphasia	12.8	GRN, TARDBP
21	prion disease	12.6	SOD1, TARDBP
22	lewy body dementia	12.5	GRN, RPS27A
23	gliosis	12.5	RPS27A, C9orf72
24	cerebral hemorrhage	12.5	SOD1, RPS27A
25	transient cerebral ischemia	12.5	RPS27A, SOD1
26	mitochondrial encephalomyopathy	12.5	SOD1, RPS27A
27	appendicitis	12.5	RPS27A, SOD1
28	encephalomyopathy	12.5	RPS27A, SOD1
29	alcohol abuse	12.4	RPS27A, SOD1
30	corticobasal degeneration	12.4	TARDBP, RPS27A
31	inclusion body myopathy	12.4	RPS27A, TARDBP
32	spinocerebellar ataxia type 3	12.4	TARDBP, RPS27A
33	spastic paraparesis	12.4	RPS27A, SOD1
34	vascular dementia	12.4	SOD1, RPS27A
35	differentiating neuroblastoma	12.3	RPS27A, SOD1
36	pulmonary sarcoidosis	12.2	SOD1, RPS27A
37	brain ischemia	12.2	SOD1, RPS27A
38	huntington's disease	12.0	RPS27A, SOD1
39	encephalitis	12.0	RPS27A, GRN, SOD1
40	semantic dementia	12.0	RPS27A, GRN, TARDBP
41	frontotemporal lobar degeneration with ubiquitin-positive inclusions	12.0	GRN, RPS27A, TARDBP
42	pick's disease	11.9	RPS27A, GRN, TARDBP
43	keratoconus	11.8	SOD1, RPS27A
44	myopathy	11.7	SOD1, TARDBP, RPS27A
45	aphasia	11.5	GRN, C9orf72, TARDBP, RPS27A
46	retinoblastoma	11.5	RPS27A, SOD1, TARDBP
47	arthritis	11.4	RPS27A, GRN, SOD1, C9orf72
48	traumatic brain injury	11.4	SOD1, TARDBP, RPS27A, GRN
49	brain injury	11.4	TARDBP, RPS27A, SOD1, GRN
50	ataxia	11.4	GRN, SOD1, TARDBP, RPS27A

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 riluzole

Genetic tests related to amyotrophic lateral sclerosis with frontotemporal dementia:

id	Genetic test	Affiliating Genes
1	Amyotrophic Lateral Sclerosis With Frontotemporal Dementia clinical/research

Articles related to amyotrophic lateral sclerosis with frontotemporal dementia:

id	Title	Authors	Year	Affiliating Genes
1	The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia. (18989115)	Mackenzie I.R.... Rademakers R.	2008	TARDBP
2	Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. (17371905)	Schymick J.C.... Traynor B.J.	2007	GRN, RPS27A
3	Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3. (16495328)	Vance C.... Shaw C.E.	2006	SOD1, C9orf72
4	Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. (11015796)	Hosler B.A.... Brown R.H.	2000	C9orf72

Genes related to amyotrophic lateral sclerosis with frontotemporal dementia according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	C9orf72	chromosome 9 open reading frame 72	11.0	Publications
2	GRN	granulin	11.0	Publications
3	TARDBP	TAR DNA binding protein	11.0	Publications
4	RPS27A	ribosomal protein S27a	11.0	Publications
5	SOD1	superoxide dismutase 1, soluble	11.0	Publications

Compounds related to amyotrophic lateral sclerosis with frontotemporal dementia according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	dicoumarol32	9.2	RPS27A, SOD1
2	formate32	9.2	RPS27A, SOD1
3	rotenone32	9.1	RPS27A, SOD1
4	levodopa32 9 9	11.1	RPS27A, SOD1
5	6-hydroxydopamine32	9.0	SOD1, RPS27A
6	4-hydroxynonenal32 18	9.8	RPS27A, SOD1

Biological processes related to amyotrophic lateral sclerosis with frontotemporal dementia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	embryo implantation	GO:007566	9.1	GRN, SOD1
2	activation of MAPK activity	GO:000187	9.1	RPS27A, SOD1