MCID: AMY006
MIFTS: 36

Amyotrophic Lateral Sclerosis with Frontotemporal Dementia malady

Neuronal diseases category

Summaries for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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46OMIM, 32MalaCards
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MalaCards: Amyotrophic Lateral Sclerosis with Frontotemporal Dementia, also known as amyotrophic lateral sclerosis and/or frontotemporal dementia 1, is related to motor neuron disease and lateral sclerosis. An important gene associated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia is C9orf72 (chromosome 9 open reading frame 72). The compounds dicoumarol and 6-hydroxydopamine have been mentioned in the context of this disorder.

Description from OMIM:46 105550,608030,612069

Aliases & Classifications for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Sources:
20GeneTests, 22GTR, 46OMIM, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
frontotemporal dementia with amyotrophic lateral sclerosis:
Inheritance: Autosomal dominant; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

amyotrophic lateral sclerosis with frontotemporal dementia 20 22
amyotrophic lateral sclerosis and/or frontotemporal dementia 1 60
amyotrophic lateral sclerosis and/or frontotemporal dementia 46
frontotemporal dementia with amyotrophic lateral sclerosis 48
frontotemporal dementia with motor neuron disease 48
frontotemporal dementia 60
ftd-mnd 48
ftd-als 48


External Ids:

SNOMED-CT via Orphanet57 230258005

Related Diseases for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Amyotrophic Lateral Sclerosis with Frontotemporal Dementia family:

Vcp-Related Amyotrophic Lateral Sclerosis/frontotemporal Dementia C9orf72-Related Amyotrophic Lateral Sclerosis/frontotemporal Dementia
Ubqln2-Related Amyotrophic Lateral Sclerosis/frontotemporal Dementia

Diseases related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1motor neuron disease31.1RPS27A, GRN, SOD1, TARDBP
2lateral sclerosis31.1TARDBP
3dementia31.1GRN, RPS27A, TARDBP
4frontotemporal dementia31.1UBQLN2, SOD1, FUS, TARDBP, RPS27A, GRN
5amyotrophic lateral sclerosis31.1GRN, C9orf72, UBQLN2, RPS27A, TARDBP, FUS
6pick's disease31.0RPS27A, TARDBP
7aphasia31.0FUS, TARDBP, C9orf72, GRN
8progressive supranuclear palsy31.0GRN, TARDBP, FUS
9tauopathy30.8RPS27A, GRN
10alzheimer's disease30.6RPS27A, SOD1, GRN, TARDBP
11parkinson's disease30.4RPS27A
12primary progressive aphasia30.3GRN, RPS27A
13frontotemporal lobar degeneration with ubiquitin-positive inclusions30.1GRN
14alcohol abuse30.1RPS27A
15semantic dementia30.1RPS27A, GRN
16neuronitis10.9
17inclusion body myopathy with early-onset paget disease and frontotemporal dementia10.8
18myopathy10.8
19grn-related frontotemporal dementia10.7
20frontotemporal dementia with parkinsonism-1710.6
21chmp2b-related frontotemporal dementia10.6
22schizophrenia10.6
23cerebritis10.5
24frontotemporal dementia, chromosome 3-linked10.5
25lewy body dementia10.5
26inclusion body myopathy with paget disease of bone and/or frontotemporal dementia10.5
27bipolar disorder10.4
28brain disease10.4
29chromosomal disease10.4
30intracranial hypotension10.4
31paget's disease of bone10.4
32frontotemporal dementia, ubiquitin-positive10.4
33inclusion body myopathy with early-onset paget disease and frontotemporal dementia 110.4
34amyotrophic lateral sclerosis 14, with or without frontotemporal dementia10.4
35vascular dementia10.3
36pathological gambling10.3
37tardbp-related frontotemporal dementia10.3
38inclusion body myopathy wtih early-onset paget disease without frontotemporal dementia 310.3
39huntington's disease10.2
40adult syndrome10.2
41vascular disease10.2
42vitamin b12 deficiency10.2
43vcp-related amyotrophic lateral sclerosis/frontotemporal dementia10.2
44c9orf72-related amyotrophic lateral sclerosis/frontotemporal dementia10.2
45ubqln2-related amyotrophic lateral sclerosis/frontotemporal dementia10.2
46dementia, familial, nonspecific10.2
47inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 210.2
48amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia10.2
49amyotrophic lateral sclerosis 15, with or without frontotemporal dementia10.2
50major depressive disorder10.1

Graphical network of the top 20 diseases related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia:



Diseases related to amyotrophic lateral sclerosis with frontotemporal dementia

Clinical Features for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Sources:
46OMIM
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Clinical features from OMIM:

105550,608030,612069

Clinical synopsis from OMIM:

105550

Drugs & Therapeutics for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Drug clinical trials:

Search ClinicalTrials for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Search NIH Clinical Center for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Search CenterWatch for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Genetic Tests for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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20GeneTests, 22GTR
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Genetic tests related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia:

id Genetic test Affiliating Genes
1 Amyotrophic Lateral Sclerosis with Frontotemporal Dementia20
2 Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis22

Anatomical Context for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Animal Models for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia or affiliated genes

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Publications for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Genetic Variations for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Expression for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

Search GEO for disease gene expression data for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia.

Pathways for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Compounds for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Sources:
44Novoseek
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Compounds related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dicoumarol449.1SOD1, RPS27A
26-hydroxydopamine449.1SOD1, RPS27A
3formate449.0SOD1, RPS27A
4rotenone448.8SOD1, RPS27A

GO Terms for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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Sources:
16Gene Ontology
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Biological processes related to Amyotrophic Lateral Sclerosis with Frontotemporal Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:0075669.0GRN, SOD1
2cell deathGO:0082197.4FUS, TARDBP, PFN1, GRN, C9orf72, UBQLN2

Products for genes affiliated with Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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  • Antibodies
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Sources for Amyotrophic Lateral Sclerosis with Frontotemporal Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet