Aliases & Classifications for Amyotrophic Neuralgia

MalaCards integrated aliases for Amyotrophic Neuralgia:

Name: Amyotrophic Neuralgia 12 14
Neuralgic Amyotrophy 12 52 69
Brachial Plexus Neuritis 42 69

Classifications:



Summaries for Amyotrophic Neuralgia

MalaCards based summary : Amyotrophic Neuralgia, also known as neuralgic amyotrophy, is related to brachial plexus neuritis and amyotrophy, hereditary neuralgic, and has symptoms including short stature, round face and cleft palate. An important gene associated with Amyotrophic Neuralgia is SEPT9 (Septin 9), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Related phenotype is Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation.

Related Diseases for Amyotrophic Neuralgia

Diseases related to Amyotrophic Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
id Related Disease Score Top Affiliating Genes
1 brachial plexus neuritis 12.4
2 amyotrophy, hereditary neuralgic 11.0
3 conotruncal heart malformations 10.1 GJB1 PMP22
4 mental retardation, x-linked, syndromic 34 10.1 GJB1 PMP22
5 congestive heart failure 10.0 PMP22 PRX
6 epileptic encephalopathy, early infantile, 51 10.0 GJB1 KIF1B
7 charcot-marie-tooth neuropathy x 10.0 GJB1 PMP22
8 pancreatic acinar cell adenocarcinoma 9.9 GJB1 PMP22
9 chromosome 16p13.2 deletion syndrome 9.8 GJB1 KIF1B PMP22
10 charcot-marie-tooth disease, type 1b 9.8 GJB1 KIF1B PMP22
11 hypertrophic osteoarthropathy, primary, autosomal recessive 2 9.8 GJB1 KIF1B PMP22
12 charcot-marie-tooth disease, type 1e 9.8 GJB1 KIF1B PMP22
13 infantile epileptic encephalopathy 9.8 GJB1 KIF1B PMP22
14 scapuloperoneal spinal muscular atrophy 9.8 GJB1 KIF1B
15 renal dysplasia, cystic 9.8 GJB1 KIF1B PMP22
16 neuropathy, recurrent, with pressure palsies 9.8 GJB1 KIF1B PMP22
17 hepatitis 9.7
18 hepatitis e 9.7
19 dysphagia 9.7
20 neuropathy, inflammatory demyelinating 9.7 GJB1 KIF1B PMP22
21 charcot-marie-tooth disease, type 1f 9.7 GJB1 KIF1B PMP22
22 thrombophilia due to antithrombin iii deficiency 9.7 KIF1B PMP22
23 charcot-marie-tooth neuropathy type 4j 9.7 GJB1 PMP22 PRX
24 hypoxia 9.6 GJB1 PMP22 PRX
25 senile angioma 9.6 GJB1 PMP22 PRX
26 ampulla of vater mucinous adenocarcinoma 9.5 GJB1 KIF1B PMP22 SEPT9
27 decubitus ulcer 9.3 GJB1 PMP22 PRX
28 dejerine-sottas disease 9.2 GJB1 KIF1B PMP22 PRX
29 neuropathy, congenital hypomyelinating 9.2 GJB1 KIF1B PMP22 PRX
30 amnestic disorder 9.2 GJB1 KIF1B PMP22 PRX
31 childhood-onset cerebral x-linked adrenoleukodystrophy 9.1 GJB1 KIF1B PMP22 PRX
32 secondary hypertrophic osteoarthropathy 7.5 AANAT GJB1 KIF1B PMP22 PRX SEPT9

Graphical network of the top 20 diseases related to Amyotrophic Neuralgia:



Diseases related to Amyotrophic Neuralgia

Symptoms & Phenotypes for Amyotrophic Neuralgia

Human phenotypes related to Amyotrophic Neuralgia:

32 (show all 15)
id Description HPO Frequency HPO Source Accession
1 short stature 32 occasional (7.5%) HP:0004322
2 round face 32 occasional (7.5%) HP:0000311
3 cleft palate 32 occasional (7.5%) HP:0000175
4 muscle weakness 32 hallmark (90%) HP:0001324
5 scapular winging 32 frequent (33%) HP:0003691
6 respiratory insufficiency 32 occasional (7.5%) HP:0002093
7 polyneuropathy 32 hallmark (90%) HP:0001271
8 acrocyanosis 32 occasional (7.5%) HP:0001063
9 sprengel anomaly 32 frequent (33%) HP:0000912
10 arthralgia 32 hallmark (90%) HP:0002829
11 paresthesia 32 frequent (33%) HP:0003401
12 sleep disturbance 32 occasional (7.5%) HP:0002360
13 narrow mouth 32 occasional (7.5%) HP:0000160
14 neurological speech impairment 32 occasional (7.5%) HP:0002167
15 emg abnormality 32 hallmark (90%) HP:0003457

GenomeRNAi Phenotypes related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.8 KIF1B PMP22 SRSF2

Drugs & Therapeutics for Amyotrophic Neuralgia

Drugs for Amyotrophic Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 Botulinum Toxins Phase 4
3 Cholinergic Agents Phase 4
4 Neurotransmitter Agents Phase 4
5
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
6 Analgesics Phase 2, Phase 3
7 Analgesics, Non-Narcotic Phase 2, Phase 3
8 Anti-Inflammatory Agents Phase 2, Phase 3
9 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
10 Antirheumatic Agents Phase 2, Phase 3
11 Cyclooxygenase Inhibitors Phase 2, Phase 3
12 Peripheral Nervous System Agents Phase 2, Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
2 Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
3 Hypoalgesic Effect of Median Nerve Neural Mobilization Compared to a Controlled Group Completed NCT02596815 Phase 2
4 Hypoalgesic Effect of Neural Mobilization Completed NCT02595294 Phase 2
5 Longitudinal Experimental Study on ULNTT and Cervico-Thoracic Spine Motion Patterns Relationship Completed NCT02632357
6 GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study Completed NCT01518582

Search NIH Clinical Center for Amyotrophic Neuralgia

Cochrane evidence based reviews: brachial plexus neuritis

Genetic Tests for Amyotrophic Neuralgia

Anatomical Context for Amyotrophic Neuralgia

Publications for Amyotrophic Neuralgia

Articles related to Amyotrophic Neuralgia:

id Title Authors Year
1
Severe bilateral amyotrophic neuralgia associated with major dysphagia secondary to acute hepatitis E. ( 24555112 )
2013

Variations for Amyotrophic Neuralgia

Expression for Amyotrophic Neuralgia

Search GEO for disease gene expression data for Amyotrophic Neuralgia.

Pathways for Amyotrophic Neuralgia

Pathways related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.63 GJB1 PMP22

GO Terms for Amyotrophic Neuralgia

Sources for Amyotrophic Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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