Aliases & Classifications for Amyotrophic Neuralgia

MalaCards integrated aliases for Amyotrophic Neuralgia:

Name: Amyotrophic Neuralgia 12 14
Neuralgic Amyotrophy 12 51 69
Brachial Plexus Neuritis 41 69

Classifications:



Summaries for Amyotrophic Neuralgia

MalaCards based summary : Amyotrophic Neuralgia, also known as neuralgic amyotrophy, is related to brachial plexus neuritis and amyotrophy, hereditary neuralgic, and has symptoms including narrow mouth, cleft palate and round face. An important gene associated with Amyotrophic Neuralgia is SEPT9 (Septin 9), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder.

Related Diseases for Amyotrophic Neuralgia

Diseases related to Amyotrophic Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 brachial plexus neuritis 12.5
2 amyotrophy, hereditary neuralgic 11.1
3 congenital hypomyelination neuropathy 9.9 PMP22 PRX
4 hepatitis 9.8
5 hepatitis e 9.8
6 dysphagia 9.8
7 roussy-levy hereditary areflexic dystasia 9.8 KIF1B PMP22
8 charcot-marie-tooth neuropathy type 1 9.8 GJB1 PMP22
9 charcot-marie-tooth disease, demyelinating, type 1f 9.7 GJB1 PMP22
10 charcot-marie-tooth disease, axonal, type 2f 9.6 GJB1 KIF1B
11 hereditary motor and sensory neuropathy, type iic 9.4 GJB1 KIF1B
12 hereditary neuropathies 9.4 GJB1 PMP22 PRX
13 sensory peripheral neuropathy 9.4 GJB1 PMP22 PRX
14 charcot-marie-tooth disease, demyelinating, type 1b 9.4 GJB1 KIF1B PMP22
15 charcot-marie-tooth disease, axonal, type 2b 9.4 GJB1 KIF1B PMP22
16 neuropathy, hereditary, with liability to pressure palsies 9.4 GJB1 KIF1B PMP22
17 peripheral nervous system disease 9.4 GJB1 PMP22
18 motor peripheral neuropathy 9.4 GJB1 KIF1B PMP22
19 charcot-marie-tooth disease, demyelinating, type 1a 9.4 GJB1 KIF1B PMP22
20 charcot-marie-tooth disease, demyelinating, type 1d 9.3 GJB1 KIF1B PMP22
21 charcot-marie-tooth disease, demyelinating, type 1c 9.3 GJB1 KIF1B PMP22
22 charcot-marie-tooth disease and deafness 9.3 GJB1 KIF1B PMP22
23 charcot-marie-tooth disease, axonal, type 2e 9.3 GJB1 KIF1B PMP22
24 neuropathy 9.2 GJB1 PMP22 PRX
25 brachial plexus neuropathy 9.1 DNAH17 KIF1B PMP22 SEC14L1 SEPT9
26 hypertrophic neuropathy of dejerine-sottas 9.0 GJB1 KIF1B PMP22 PRX
27 neuropathy, congenital hypomyelinating or amyelinating, autosomal recessive 9.0 GJB1 KIF1B PMP22 PRX
28 tooth disease 9.0 GJB1 KIF1B PMP22 PRX
29 charcot-marie-tooth disease 8.9 GJB1 KIF1B PMP22 PRX

Graphical network of the top 20 diseases related to Amyotrophic Neuralgia:



Diseases related to Amyotrophic Neuralgia

Symptoms & Phenotypes for Amyotrophic Neuralgia

Human phenotypes related to Amyotrophic Neuralgia:

31 (show all 15)
# Description HPO Frequency HPO Source Accession
1 narrow mouth 31 occasional (7.5%) HP:0000160
2 cleft palate 31 occasional (7.5%) HP:0000175
3 round face 31 occasional (7.5%) HP:0000311
4 sprengel anomaly 31 frequent (33%) HP:0000912
5 acrocyanosis 31 occasional (7.5%) HP:0001063
6 polyneuropathy 31 hallmark (90%) HP:0001271
7 muscle weakness 31 hallmark (90%) HP:0001324
8 respiratory insufficiency 31 occasional (7.5%) HP:0002093
9 neurological speech impairment 31 occasional (7.5%) HP:0002167
10 sleep disturbance 31 occasional (7.5%) HP:0002360
11 arthralgia 31 hallmark (90%) HP:0002829
12 paresthesia 31 frequent (33%) HP:0003401
13 emg abnormality 31 hallmark (90%) HP:0003457
14 scapular winging 31 frequent (33%) HP:0003691
15 short stature 31 occasional (7.5%) HP:0004322

Drugs & Therapeutics for Amyotrophic Neuralgia

Drugs for Amyotrophic Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 Botulinum Toxins Phase 4
3 Cholinergic Agents Phase 4
4 Neurotransmitter Agents Phase 4
5
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
6 Analgesics Phase 2, Phase 3
7 Analgesics, Non-Narcotic Phase 2, Phase 3
8 Anti-Inflammatory Agents Phase 2, Phase 3
9 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
10 Antirheumatic Agents Phase 2, Phase 3
11 Cyclooxygenase Inhibitors Phase 2, Phase 3
12 Peripheral Nervous System Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
2 Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
3 Hypoalgesic Effect of Median Nerve Neural Mobilization Compared to a Controlled Group Completed NCT02596815 Phase 2
4 Hypoalgesic Effect of Neural Mobilization Completed NCT02595294 Phase 2
5 Longitudinal Experimental Study on ULNTT and Cervico-Thoracic Spine Motion Patterns Relationship Completed NCT02632357
6 GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study Completed NCT01518582
7 Cervicobrachial Neuralgia and Sagital Balance of the Cervical Spine Recruiting NCT03397459
8 Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction Not yet recruiting NCT03441347

Search NIH Clinical Center for Amyotrophic Neuralgia

Cochrane evidence based reviews: brachial plexus neuritis

Genetic Tests for Amyotrophic Neuralgia

Anatomical Context for Amyotrophic Neuralgia

Publications for Amyotrophic Neuralgia

Articles related to Amyotrophic Neuralgia:

(show top 50) (show all 55)
# Title Authors Year
1
Neuralgic amyotrophy following high-dose melphalan and autologous peripheral blood stem cell transplantation for AL amyloidosis. ( 29269794 )
2017
2
Chronic Brachial Plexus Neuritis that Developed into Typical Neuralgic Amyotrophy and Positively Responded to Immunotherapy. ( 29269655 )
2017
3
Ultrasonographic findings of proximal median neuropathy: A case series of suspected distal neuralgic amyotrophy. ( 28477674 )
2017
4
Incidence of neuralgic amyotrophy (Parsonage Turner syndrome) in a primary care setting--a prospective cohort study. ( 26016482 )
2015
5
Neuralgic amyotrophy manifested by severe axillary mononeuropathy limited only to the anterior branch. ( 25418351 )
2014
6
Neuralgic amyotrophy (Parsonage Turner syndrome). ( 24495384 )
2014
7
Neuralgic amyotrophy and hepatitis E virus infection. ( 24401685 )
2014
8
Neonatal vocal cord paralysis-an early presentation of hereditary neuralgic amyotrophy due to a mutation in the SEPT9 gene. ( 22981636 )
2013
9
Severe bilateral amyotrophic neuralgia associated with major dysphagia secondary to acute hepatitis E. ( 24555112 )
2013
10
Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules. ( 24344182 )
2013
11
Neuralgic amyotrophy (Parsonage-Turner syndrome). ( 22751163 )
2012
12
Acute shoulder-girdle neuralgic amyotrophy (Parsonage-Turner syndrome with saphenous nerve involvement. ( 22368976 )
2011
13
Non-recurrent SEPT9 duplications cause hereditary neuralgic amyotrophy. ( 19939853 )
2010
14
Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9 R88W mutation. ( 20019224 )
2010
15
Neuralgic amyotrophy: Parsonage-Turner Syndrome. ( 21035964 )
2010
16
SEPT9 gene sequencing analysis reveals recurrent mutations in hereditary neuralgic amyotrophy. ( 19451530 )
2009
17
Duplication within the SEPT9 gene associated with a founder effect in North American families with hereditary neuralgic amyotrophy. ( 19139049 )
2009
18
Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis). ( 19588414 )
2009
19
Isolated spinal accessory mononeuropathy associated with neurogenic muscle hypertrophy: restricted neuralgic amyotrophy or stretch-palsy? A case report. ( 18295637 )
2008
20
Dysmorphic syndrome of hereditary neuralgic amyotrophy associated with a SEPT9 gene mutation -- a family study. ( 18492087 )
2008
21
SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling. ( 17546647 )
2007
22
Inherited focal, episodic neuropathies: hereditary neuropathy with liability to pressure palsies and hereditary neuralgic amyotrophy. ( 16775374 )
2006
23
A4V superoxide dismutase mutation in apparently sporadic ALS resembling neuralgic amyotrophy. ( 16546761 )
2006
24
Histology of hereditary neuralgic amyotrophy. ( 15716548 )
2005
25
Mutations in SEPT9 cause hereditary neuralgic amyotrophy. ( 16186812 )
2005
26
Notalgia paresthetica following neuralgic amyotrophy: a case report. ( 15060814 )
2004
27
Genomic organization and mutation analysis of three candidate genes for hereditary neuralgic amyotrophy. ( 15052627 )
2004
28
Neuralgic amyotrophy as a manifestation of infectious mononucleosis. ( 12532929 )
2002
29
Evidence of a founder effect and refinement of the hereditary neuralgic amyotrophy (HNA) locus on 17q25 in American families. ( 11935323 )
2002
30
Hereditary Neuralgic Amyotrophy (HNA) is genetically heterogeneous. ( 11697522 )
2001
31
Hereditary neuralgic amyotrophy. ( 11523561 )
2001
32
Evidence for genetic heterogeneity in hereditary neuralgic amyotrophy. ( 11245726 )
2001
33
Craniofacial and cutaneous findings expand the phenotype of hereditary neuralgic amyotrophy. ( 11739810 )
2001
34
Mutation analysis of 4 candidate genes for hereditary neuralgic amyotrophy (HNA). ( 11409865 )
2001
35
The natural history of hereditary neuralgic amyotrophy in the Dutch population: two distinct types? ( 10734003 )
2000
36
Diagnostic guidelines for hereditary neuralgic amyotrophy or heredofamilial neuritis with brachial plexus predilection. On behalf of the European CMT Consortium. ( 10996784 )
2000
37
Genetic refinement of the hereditary neuralgic amyotrophy (HNA) locus at chromosome 17q25. ( 10602368 )
1999
38
Hereditary neuralgic amyotrophy: mutation analysis of candidate genes. ( 10586268 )
1999
39
Neuralgic amyotrophy (Parsonage-Turner syndrome): an often misdiagnosed diagnosis. ( 10540541 )
1999
40
Mutation analysis of a putative sialyltransferase gene, the SFRS2 splicing factor gene and the c-myb ET-locus in two families with hereditary neuralgic amyotrophy (HNA). ( 10088036 )
1998
41
[Two cases of neuralgic amyotrophy]. ( 9868314 )
1998
42
Hereditary neuralgic amyotrophy: evidence for genetic homogeneity and mapping to chromosome 17q25. ( 9439655 )
1997
43
Refinement of the hereditary neuralgic amyotrophy (HNA) locus to chromosome 17q24-q25. ( 9150742 )
1997
44
Further evidence supporting linkage of hereditary neuralgic amyotrophy to chromosome 17q. ( 9191796 )
1997
45
Mapping of hereditary neuralgic amyotrophy (familial brachial plexus neuropathy) to distal chromosome 17q. ( 8780104 )
1996
46
Hereditary neuralgic amyotrophy. ( 8894409 )
1996
47
Neuralgic amyotrophy and infectious mononucleosis: a case report. ( 24283643 )
1995
48
Hereditary neuralgic amyotrophy and hereditary neuropathy with liability to pressure palsies: two distinct clinical, electrophysiologic, and genetic entities. ( 7991107 )
1994
49
Hereditary neuralgic amyotrophy and hereditary neuropathy with liability to pressure palsies: two distinct genetic disorders. ( 7991108 )
1994
50
Hereditary Neuralgic Amyotrophy ( 20301569 )
1993

Variations for Amyotrophic Neuralgia

Expression for Amyotrophic Neuralgia

Search GEO for disease gene expression data for Amyotrophic Neuralgia.

Pathways for Amyotrophic Neuralgia

Pathways related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.63 GJB1 PMP22

GO Terms for Amyotrophic Neuralgia

Cellular components related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axoneme GO:0005930 8.96 DNAH17 SEPT9
2 microtubule GO:0005874 8.8 DNAH17 KIF1B SEPT9

Biological processes related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based movement GO:0007018 8.62 DNAH17 KIF1B

Molecular functions related to Amyotrophic Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motor activity GO:0003774 8.96 DNAH17 KIF1B
2 microtubule motor activity GO:0003777 8.62 DNAH17 KIF1B

Sources for Amyotrophic Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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