MCID: ANL011
MIFTS: 50

Anal Canal Carcinoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Anal Canal Carcinoma

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8Disease Ontology, 47OMIM, 33MalaCards
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Disease Ontology:8 A carcinoma that is manifested in the anal canal.

MalaCards: Anal Canal Carcinoma, also known as carcinoma of anal canal, is related to leukemia and adenocarcinoma. An important gene associated with Anal Canal Carcinoma is ANC (Anal canal carcinoma), and among its related pathways are Validated targets of C-MYC transcriptional activation and Doxorubicin Pathway, Pharmacokinetics. The compounds slex and dicoumarol have been mentioned in the context of this disorder. Affiliated tissues include skin and prostate, and related mouse phenotypes are respiratory system and digestive/alimentary.

Description from OMIM:47 105580

Aliases & Classifications for Anal Canal Carcinoma

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Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 62UMLS, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

anal canal carcinoma 8 9 47
carcinoma of anal canal 8 62
anal canal and perianal gland carcinoma 8
anal canal cancer 8


External Ids:

Disease Ontology8 DOID:6126, DOID:0050688
NCIt40 C7489
SNOMED-CT58 285310000
OMIM47 105580
ICD1025 C21.1

Related Diseases for Anal Canal Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anal Canal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.1CDKN2A, NME1, TP53, NQO1, PECAM1
2adenocarcinoma30.0PECAM1, NQO1, TP53, NME1, GLI1, CDKN2A
3burns10.2
4anal carcinoma in situ10.2
5prostate adenocarcinoma10.2
6prostatitis10.2
7actinic keratosis10.1TP53
8neuroblastoma10.1NME1, TP53
9breast cancer, invasive ductal10.0NME1, TP53
10laryngeal benign neoplasm10.0NME1, TP53
11basal cell carcinoma10.0GLI1, TP53
12pancreatic cancer10.0GLI1, NQO1
13gastric adenocarcinoma10.0GLI1, NME1
14transitional cell carcinoma10.0NME1, TP53
15xeroderma pigmentosum10.0TP53, NQO1
16lung cancer10.0TP53, CDKN2A
17carcinoid syndrome10.0NQO1, GLI1
18cervical adenocarcinoma10.0CDKN2A, NME1
19oropharyngeal cancer, adult10.0CDKN2A, TP53
20cervical intraepithelial neoplasia10.0CDKN2A, NME1
21li-fraumeni syndrome10.0CDKN2A, TP53
22nasopharynx carcinoma10.0CDKN2A, TP53
23intraocular melanoma10.0CDKN2A, NME1
24barrett's esophagus10.0TP53, CDKN2A
25bladder carcinoma in situ10.0CDKN2A, TP53
26anaplastic astrocytoma10.0CDKN2A, TP53
27esophageal cancer10.0CDKN2A, TP53
28oligodendroglioma10.0TP53, CDKN2A
29brain cancer10.0GLI1, TP53, PECAM1
30sarcoma10.0GLI1, TP53, PECAM1
31benign mesothelioma10.0PECAM1, CDKN2A
32papilloma10.0TP53, CDKN2A
33oral cancer10.0TP53, CDKN2A
34acute lymphoblastic leukemia, childhood10.0NQO1, CDKN2A
35multiple myeloma10.0CDKN2A, TP53
36laryngeal squamous cell carcinoma10.0TP53, NME1, CDKN2A
37b-cell chronic lymphocytic leukemia10.0TP53, PECAM1
38malignant glioma10.0TP53, GLI1, CDKN2A
39squamous cell carcinoma of the head and neck10.0TP53, NME1, CDKN2A
40endometrial carcinoma10.0CDKN2A, NME1, TP53
41cervical cancer10.0CDKN2A, NME1, TP53
42colorectal cancer10.0TP53, NME1, CDKN2A
43bladder carcinoma10.0CDKN2A, TP53
44retinoblastoma10.0CDKN2A, NME1, TP53
45lung small cell carcinoma9.9NQO1, TP53, CDKN2A
46breast cancer9.9NME1, TP53, NQO1, PECAM1
47prostate cancer9.9PECAM1, NQO1, TP53, GLI1
48osteosarcoma9.9CDKN2A, GLI1, NME1, TP53
49non-small cell lung carcinoma9.9CDKN2A, NME1, TP53, NQO1
50burkitt's lymphoma9.9NQO1, TP53, CDKN2A

Graphical network of the top 20 diseases related to Anal Canal Carcinoma:



Diseases related to anal canal carcinoma

Symptoms for Anal Canal Carcinoma

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Sources:
47OMIM
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Clinical features from OMIM:

105580

Drugs & Therapeutics for Anal Canal Carcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Anal Canal Carcinoma

Search NIH Clinical Center for Anal Canal Carcinoma

Genetic Tests for Anal Canal Carcinoma

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Anatomical Context for Anal Canal Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Anal Canal Carcinoma:

33
Skin, Prostate

Animal Models for Anal Canal Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Anal Canal Carcinoma:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4CDKN2A, GLI1, TP53, PECAM1
2MP:00053818.3PECAM1, TP53, GLI1, CDKN2A
3MP:00053798.3CDKN2A, GLI1, NME1, TP53
4MP:00053808.0TP53, NME1, GLI1, CDKN2A
5MP:00107718.0NQO1, TP53, NME1, CDKN2A
6MP:00020067.9CDKN2A, GLI1, NME1, TP53, NQO1
7MP:00053707.8PECAM1, NQO1, TP53, NME1, CDKN2A
8MP:00053977.7PECAM1, NQO1, TP53, NME1, CDKN2A
9MP:00053787.7NQO1, TP53, NME1, GLI1, CDKN2A
10MP:00053847.7PECAM1, NQO1, TP53, GLI1, CDKN2A
11MP:00053767.5CDKN2A, NME1, TP53, NQO1, PECAM1

Publications for Anal Canal Carcinoma

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Sources:
52PubMed
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Articles related to Anal Canal Carcinoma:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (24243447)
2014
2
Changing patterns of anal canal carcinoma in the United States. (23509304)
2013
3
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (23674135)
2013
4
Light microscopic observation on phagocytosis of Candida spp. blastospores by Trichomonas vaginalis in a patient with anal canal carcinoma. (21395883)
2012
5
Chemotherapy in the treatment of anal canal carcinoma. (22658644)
2012
6
Endobronchial metastases of anal canal carcinoma. (22055765)
2012
7
Twenty-year experience in the management of squamous cell anal canal carcinoma with interstitial brachytherapy. (21775274)
2011
8
Results of salvage abdominoperineal resection after failed chemoradiation therapy for epidermoid anal canal carcinoma: Retrospective analysis at a single institution. (22331724)
2011
9
Anal canal carcinoma treatment results: the experience of a single institution. (21403412)
2011
10
Mitomycin-C- or cisplatin-based chemoradiotherapy for anal canal carcinoma: long-term results. (20472349)
2011
11
Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma. (20492729)
2010
12
Molecular biomarkers correlate with disease-free survival in patients with anal canal carcinoma treated with chemoradiation. (19399614)
2010
13
Conformal external beam radiotherapy in the treatment of anal canal carcinoma: a retrospective study of a genital organ sparing technique. (19695047)
2009
14
Induction therapy for poor-prognosis anal canal carcinoma: a phase II study of the cancer and Leukemia Group B (CALGB 9281). (18490648)
2008
15
Radiochemotherapy of locally advanced anal canal carcinoma: prospective assessment of early impact on the quality of life (randomized trial ACCORD 03). (18191265)
2008
16
Radiotherapy and chemotherapy in the conservative treatment of anal canal carcinoma. (18505075)
2008
17
Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans. (18005443)
2007
18
The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas. (18060184)
2007
19
Anal canal carcinoma with Pagetoid spread: report of a case. (16794808)
2006
20
Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: a retrospective study. (16631268)
2006
21
Epidermal growth factor receptor expression in anal canal carcinoma. (15923158)
2005
22
Anal canal carcinoma: early-stage tumors < or =10 mm (T1 or Tis): therapeutic options and original pattern of local failure after radiotherapy. (15890590)
2005
23
Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of results and radiation dose effectiveness. (15752894)
2005
24
Contribution of conformal therapy in the treatment of anal canal carcinoma with combined chemotherapy and radiotherapy: results of a phase II study. (12788191)
2003
25
Analysis of a follow-up program for anal canal carcinoma. (11484975)
2001
26
Prognostic impact of CD31 antigen expression in anal canal carcinoma. (11677963)
2001
27
Intracavitary afterloading boost in anal canal carcinoma. Results, function and quality of life. (11398611)
2001
28
The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy. (11395235)
2001
29
nm23-H1 protein expression in anal canal carcinoma: does it correlate with prognosis? (10914829)
2000
30
An unusual late radiotherapy-related complication requiring surgery in anal canal carcinoma. (10914830)
2000
31
Immunohistochemical assessment of Ki-67 as prognostic cellular proliferation marker in anal canal carcinoma. (11277325)
2000
32
Treatment of squamous cell anal canal carcinoma with pulsed dose rate brachytherapy. Feasibility study of a French cooperative group. (10435803)
1999
33
Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma. (10523705)
1999
34
Human papillomavirus infection and p53 nuclear overexpression in anal canal carcinoma. (10374676)
1999
35
Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C. (9788412)
1998
36
The prevalence of p53 immunoreactivity in anal canal carcinoma. (9769387)
1998
37
Role of dose intensity in conservative treatment of anal canal carcinoma. Report of 35 cases. (9778618)
1998
38
Sphincter preservation with chemoradiation in anal canal carcinoma: abdominoperineal resection in selected cases? (9559628)
1998
39
Epidermoid anal canal carcinoma metastatic to the skin. A clinical mimic of prostate adenocarcinoma metastases. (7962940)
1994
40
Mitomycin in anal canal carcinoma. (8483559)
1993
41
Late recurrence following treatment of anal canal carcinoma. (1712526)
1991
42
Feasibility of non-surgical definitive management of anal canal carcinoma. (3384732)
1988
43
Our experience of conservative treatment of anal canal carcinoma combining external irradiation and interstitial implant: 32 cases treated between 1973 and 1982. (3338946)
1988
44
Feasibility of non-surgical definitive management of anal canal carcinoma. (3104242)
1987
45
Recurrent deletions of chromosomes 11q and 3p in anal canal carcinoma. (3570551)
1987
46
Treatment of anal canal carcinoma. (3919927)
1985
47
Results and toxicity of the treatment of anal canal carcinoma by radiation therapy or radiation therapy and chemotherapy. (6435851)
1984
48
Radiation therapy and chemotherapy in the treatment of primary anal canal carcinoma. (6831854)
1983
49
Definitive treatment of anal-canal carcinoma by means of radiation therapy and chemotherapy. (6813084)
1982
50
Primary radiation therapy in the treatment of anal canal carcinoma. (7172946)
1982

Variations for Anal Canal Carcinoma

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Expression for genes affiliated with Anal Canal Carcinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anal Canal Carcinoma

Search GEO for disease gene expression data for Anal Canal Carcinoma.

Pathways for genes affiliated with Anal Canal Carcinoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 53QIAGEN, 55Reactome, 30KEGG, 60Thomson Reuters
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Compounds for genes affiliated with Anal Canal Carcinoma

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Sources:
45Novoseek, 3BitterDB, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1slex459.8NME1, PECAM1
2dicoumarol459.7NQO1, TP53
3aristolochic acid45 310.7NQO1, TP53
43,3-diindolylmethane459.7NQO1, TP53
55 aminosalicylic acid459.7NQO1, PECAM1
617-(allylamino)-17-demethoxygeldanamycin459.7NQO1, NME1
7fluorouracil51 1110.7NQO1, TP53
8indole-3-carbinol459.6TP53, NQO1
9benzo(a)pyrene459.6NQO1, TP53
10acnu459.6CDKN2A, TP53
11hpvs459.5CDKN2A, TP53
12oxaliplatin45 51 1111.5TP53, NQO1
135-methylcytosine45 2410.5TP53, CDKN2A
14olomoucine45 1110.5TP53, CDKN2A
15temozolomide45 1110.5CDKN2A, TP53
16aflatoxin b145 2410.5TP53, CDKN2A
17hmba459.5TP53, CDKN2A
18o6-methylguanine459.5CDKN2A, TP53
19depsipeptide459.4CDKN2A, TP53
20melphalan45 51 1111.4TP53, NQO1
21roscovitine459.4CDKN2A, TP53
22bleomycin45 1110.3TP53, NQO1
23flavopiridol45 1110.2CDKN2A, TP53
24thymidine45 2410.2NME1, TP53, PECAM1
25hematoxylin459.1PECAM1, CDKN2A
26crcs459.1TP53, NME1, CDKN2A
27bcnu459.0CDKN2A, TP53, NQO1
28thymidylate458.9CDKN2A, TP53, NQO1
29cytarabine45 51 1110.9NQO1, TP53, CDKN2A
30adriamycin458.9CDKN2A, TP53, NQO1
31daunorubicin45 51 1110.9CDKN2A, NQO1
32camptothecin45 61 1110.9NQO1, TP53, CDKN2A
33arsenite45 249.9CDKN2A, TP53, NQO1
34actinomycin d458.9CDKN2A, TP53, PECAM1
35n acetylcysteine458.9NQO1, TP53, CDKN2A
36doxorubicin45 51 1110.8CDKN2A, TP53, NQO1
37creatinine458.8NQO1, NME1, CDKN2A
38aspartate458.7CDKN2A, NME1, NQO1
39paraffin458.6CDKN2A, NME1, TP53, PECAM1
40vegf458.6PECAM1, TP53, NME1, CDKN2A
41retinoic acid45 249.5CDKN2A, NME1, TP53, PECAM1
425fluorouracil458.5CDKN2A, NME1, TP53, NQO1
43agar458.5CDKN2A, NME1, NQO1, PECAM1
44cisplatin45 51 61 1111.5NQO1, TP53, NME1, CDKN2A
45cycloheximide458.4PECAM1, NQO1, TP53, CDKN2A
46h2o2458.4CDKN2A, TP53, NQO1, PECAM1
47cysteine458.4PECAM1, NQO1, NME1, CDKN2A
48progesterone45 29 61 24 1112.4CDKN2A, NME1, TP53
49estrogen458.0PECAM1, NQO1, TP53, NME1, CDKN2A
50serine457.9PECAM1, NQO1, TP53, NME1, CDKN2A

GO Terms for genes affiliated with Anal Canal Carcinoma

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16Gene Ontology
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Cellular components related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166048.8CDKN2A, TP53
2cytosolGO:0058297.6CDKN2A, GLI1, NME1, TP53, NQO1

Biological processes related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to drugGO:0356909.4NME1, TP53
2positive regulation of neuron apoptotic processGO:0435259.4TP53, NQO1
3replicative senescenceGO:0903999.3CDKN2A, TP53
4positive regulation of cell cycle arrestGO:0711589.2CDKN2A, TP53
5Ras protein signal transductionGO:0072659.1CDKN2A, TP53
6negative regulation of cell proliferationGO:0082858.7TP53, NME1, CDKN2A
7positive regulation of transcription, DNA-templatedGO:0458938.4CDKN2A, GLI1, TP53

Molecular functions related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.1CDKN2A, TP53
2p53 bindingGO:0020398.8TP53, CDKN2A
3protein kinase bindingGO:0199018.6CDKN2A, NME1, TP53
4protein bindingGO:0055157.1CDKN2A, GLI1, NME1, TP53, NQO1, PECAM1

Products for genes affiliated with Anal Canal Carcinoma

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Sources for Anal Canal Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet