MCID: ANL011
MIFTS: 50

Anal Canal Carcinoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Anal Canal Carcinoma

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Disease Ontology:8 An anal canal cancer that derives from epithelial cells.

MalaCards based summary: Anal Canal Carcinoma, also known as carcinoma of anal canal, is related to leukemia and adenocarcinoma. An important gene associated with Anal Canal Carcinoma is ANC (Anal canal carcinoma), and among its related pathways are Validated targets of C-MYC transcriptional activation and Doxorubicin Pathway, Pharmacokinetics. The compounds slex and dicoumarol have been mentioned in the context of this disorder. Affiliated tissues include skin and prostate, and related mouse phenotypes are respiratory system and digestive/alimentary.

Description from OMIM:46 105580

Aliases & Classifications for Anal Canal Carcinoma

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Anal Canal Carcinoma, Aliases & Descriptions:

Name: Anal Canal Carcinoma 8 9 46
Carcinoma of Anal Canal 8 62
 
Anal Canal and Perianal Gland Carcinoma 8
Anal Canal Cancer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:6126, DOID:0050688
NCIt39 C7489
SNOMED-CT57 285310000
OMIM46 105580
ICD1025 C21.1

Related Diseases for Anal Canal Carcinoma

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Diseases related to Anal Canal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia29.4CDKN2A, NME1, TP53, NQO1, PECAM1
2adenocarcinoma29.1PECAM1, NQO1, TP53, NME1, GLI1, CDKN2A
3actinic keratosis10.4TP53
4neuroblastoma10.2NME1, TP53
5breast cancer, invasive ductal10.2NME1, TP53
6breast ductal carcinoma10.2TP53, NME1
7burns10.2
8anal carcinoma in situ10.2
9prostate adenocarcinoma10.2
10prostatitis10.2
11laryngeal benign neoplasm10.2NME1, TP53
12anal canal squamous cell carcinoma10.2
13anal canal adenocarcinoma10.2
14basal cell carcinoma10.2GLI1, TP53
15pancreatic cancer10.1GLI1, NQO1
16xeroderma pigmentosum10.1TP53, NQO1
17gastric adenocarcinoma10.1GLI1, NME1
18transitional cell carcinoma10.1NME1, TP53
19lung cancer10.1TP53, CDKN2A
20carcinoid syndrome10.1NQO1, GLI1
21cervical adenocarcinoma10.1CDKN2A, NME1
22oropharyngeal cancer, adult10.1CDKN2A, TP53
23cervical intraepithelial neoplasia10.1CDKN2A, NME1
24li-fraumeni syndrome10.1CDKN2A, TP53
25nasopharynx carcinoma10.1CDKN2A, TP53
26uveal melanoma10.1CDKN2A, NME1
27barrett's esophagus10.0TP53, CDKN2A
28bladder carcinoma in situ10.0CDKN2A, TP53
29grade iii astrocytoma10.0CDKN2A, TP53
30esophageal cancer10.0CDKN2A, TP53
31oligodendroglioma10.0TP53, CDKN2A
32brain cancer10.0GLI1, TP53, PECAM1
33malignant mesothelioma10.0PECAM1, CDKN2A
34sarcoma10.0GLI1, TP53, PECAM1
35papilloma10.0TP53, CDKN2A
36oral cancer10.0TP53, CDKN2A
37acute lymphoblastic leukemia, childhood10.0NQO1, CDKN2A
38squamous cell carcinoma of the head and neck10.0TP53, CDKN2A
39multiple myeloma9.9CDKN2A, TP53
40laryngeal squamous cell carcinoma9.9TP53, NME1, CDKN2A
41malignant glioma9.9TP53, GLI1, CDKN2A
42chronic lymphocytic leukemia9.9TP53, PECAM1
43endometrial carcinoma9.9CDKN2A, NME1, TP53
44cervical cancer9.9CDKN2A, NME1, TP53
45colorectal cancer9.8TP53, NME1, CDKN2A
46bladder carcinoma9.8CDKN2A, TP53
47retinoblastoma9.8CDKN2A, NME1, TP53
48lung small cell carcinoma9.8NQO1, TP53, CDKN2A
49breast cancer9.7NME1, TP53, NQO1, PECAM1
50prostate cancer9.7PECAM1, NQO1, TP53, GLI1

Graphical network of the top 20 diseases related to Anal Canal Carcinoma:



Diseases related to anal canal carcinoma

Symptoms for Anal Canal Carcinoma

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Clinical features from OMIM:

105580

Drugs & Therapeutics for Anal Canal Carcinoma

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Drug clinical trials:

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Search NIH Clinical Center for Anal Canal Carcinoma

Genetic Tests for Anal Canal Carcinoma

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Anatomical Context for Anal Canal Carcinoma

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MalaCards organs/tissues related to Anal Canal Carcinoma:

32
Skin, Prostate

Animal Models for Anal Canal Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Anal Canal Carcinoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4CDKN2A, GLI1, TP53, PECAM1
2MP:00053818.3PECAM1, TP53, GLI1, CDKN2A
3MP:00053798.3CDKN2A, GLI1, NME1, TP53
4MP:00053808.0TP53, NME1, GLI1, CDKN2A
5MP:00107718.0NQO1, TP53, NME1, CDKN2A
6MP:00020067.9CDKN2A, GLI1, NME1, TP53, NQO1
7MP:00053707.8PECAM1, NQO1, TP53, NME1, CDKN2A
8MP:00053977.7PECAM1, NQO1, TP53, NME1, CDKN2A
9MP:00053787.7NQO1, TP53, NME1, GLI1, CDKN2A
10MP:00053847.7PECAM1, NQO1, TP53, GLI1, CDKN2A
11MP:00053767.5CDKN2A, NME1, TP53, NQO1, PECAM1

Publications for Anal Canal Carcinoma

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Articles related to Anal Canal Carcinoma:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (24243447)
2014
2
Management of persistent anal canal carcinoma after combined-modality therapy: a clinical review. (24472223)
2014
3
Benefit of MRI scanning in the pretreatment assessment of anal canal carcinoma. (24674573)
2013
4
Changing patterns of anal canal carcinoma in the United States. (23509304)
2013
5
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (23674135)
2013
6
Light microscopic observation on phagocytosis of Candida spp. blastospores by Trichomonas vaginalis in a patient with anal canal carcinoma. (21395883)
2012
7
Chemotherapy in the treatment of anal canal carcinoma. (22658644)
2012
8
Twenty-year experience in the management of squamous cell anal canal carcinoma with interstitial brachytherapy. (21775274)
2011
9
Results of salvage abdominoperineal resection after failed chemoradiation therapy for epidermoid anal canal carcinoma: Retrospective analysis at a single institution. (22331724)
2011
10
Anal canal carcinoma treatment results: the experience of a single institution. (21403412)
2011
11
Mitomycin-C- or cisplatin-based chemoradiotherapy for anal canal carcinoma: long-term results. (20472349)
2011
12
Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma. (20492729)
2010
13
Molecular biomarkers correlate with disease-free survival in patients with anal canal carcinoma treated with chemoradiation. (19399614)
2010
14
Conformal external beam radiotherapy in the treatment of anal canal carcinoma: a retrospective study of a genital organ sparing technique. (19695047)
2009
15
Induction therapy for poor-prognosis anal canal carcinoma: a phase II study of the cancer and Leukemia Group B (CALGB 9281). (18490648)
2008
16
Radiochemotherapy of locally advanced anal canal carcinoma: prospective assessment of early impact on the quality of life (randomized trial ACCORD 03). (18191265)
2008
17
Radiotherapy and chemotherapy in the conservative treatment of anal canal carcinoma. (18505075)
2008
18
Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans. (18005443)
2007
19
The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas. (18060184)
2007
20
Anal canal carcinoma with Pagetoid spread: report of a case. (16794808)
2006
21
Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: a retrospective study. (16631268)
2006
22
Epidermal growth factor receptor expression in anal canal carcinoma. (15923158)
2005
23
Anal canal carcinoma: early-stage tumors < or =10 mm (T1 or Tis): therapeutic options and original pattern of local failure after radiotherapy. (15890590)
2005
24
Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of results and radiation dose effectiveness. (15752894)
2005
25
Contribution of conformal therapy in the treatment of anal canal carcinoma with combined chemotherapy and radiotherapy: results of a phase II study. (12788191)
2003
26
Analysis of a follow-up program for anal canal carcinoma. (11484975)
2001
27
Prognostic impact of CD31 antigen expression in anal canal carcinoma. (11677963)
2001
28
Intracavitary afterloading boost in anal canal carcinoma. Results, function and quality of life. (11398611)
2001
29
The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy. (11395235)
2001
30
nm23-H1 protein expression in anal canal carcinoma: does it correlate with prognosis? (10914829)
2000
31
An unusual late radiotherapy-related complication requiring surgery in anal canal carcinoma. (10914830)
2000
32
Immunohistochemical assessment of Ki-67 as prognostic cellular proliferation marker in anal canal carcinoma. (11277325)
2000
33
Treatment of squamous cell anal canal carcinoma with pulsed dose rate brachytherapy. Feasibility study of a French cooperative group. (10435803)
1999
34
Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma. (10523705)
1999
35
Human papillomavirus infection and p53 nuclear overexpression in anal canal carcinoma. (10374676)
1999
36
Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C. (9788412)
1998
37
The prevalence of p53 immunoreactivity in anal canal carcinoma. (9769387)
1998
38
Role of dose intensity in conservative treatment of anal canal carcinoma. Report of 35 cases. (9778618)
1998
39
Sphincter preservation with chemoradiation in anal canal carcinoma: abdominoperineal resection in selected cases? (9559628)
1998
40
Epidermoid anal canal carcinoma metastatic to the skin. A clinical mimic of prostate adenocarcinoma metastases. (7962940)
1994
41
Late recurrence following treatment of anal canal carcinoma. (1712526)
1991
42
Feasibility of non-surgical definitive management of anal canal carcinoma. (3384732)
1988
43
Our experience of conservative treatment of anal canal carcinoma combining external irradiation and interstitial implant: 32 cases treated between 1973 and 1982. (3338946)
1988
44
Feasibility of non-surgical definitive management of anal canal carcinoma. (3104242)
1987
45
Recurrent deletions of chromosomes 11q and 3p in anal canal carcinoma. (3570551)
1987
46
Treatment of anal canal carcinoma. (3919927)
1985
47
Results and toxicity of the treatment of anal canal carcinoma by radiation therapy or radiation therapy and chemotherapy. (6435851)
1984
48
Radiation therapy and chemotherapy in the treatment of primary anal canal carcinoma. (6831854)
1983
49
Definitive treatment of anal-canal carcinoma by means of radiation therapy and chemotherapy. (6813084)
1982
50
Primary radiation therapy in the treatment of anal canal carcinoma. (7172946)
1982

Variations for Anal Canal Carcinoma

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Expression for genes affiliated with Anal Canal Carcinoma

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Expression patterns in normal tissues for genes affiliated with Anal Canal Carcinoma

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Pathways for genes affiliated with Anal Canal Carcinoma

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Compounds for genes affiliated with Anal Canal Carcinoma

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Compounds related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1slex449.8NME1, PECAM1
2dicoumarol449.7NQO1, TP53
3aristolochic acid44 210.7NQO1, TP53
43,3-diindolylmethane449.7NQO1, TP53
55 aminosalicylic acid449.7NQO1, PECAM1
617-(allylamino)-17-demethoxygeldanamycin449.7NQO1, NME1
7fluorouracil50 1110.7NQO1, TP53
8indole-3-carbinol449.6TP53, NQO1
9benzo(a)pyrene449.6NQO1, TP53
10acnu449.6CDKN2A, TP53
11hpvs449.5CDKN2A, TP53
12oxaliplatin44 50 1111.5TP53, NQO1
135-methylcytosine44 2410.5TP53, CDKN2A
14olomoucine44 1110.5TP53, CDKN2A
15temozolomide44 1110.5CDKN2A, TP53
16aflatoxin b144 2410.5TP53, CDKN2A
17hmba449.5TP53, CDKN2A
18o6-methylguanine449.5CDKN2A, TP53
19depsipeptide449.4CDKN2A, TP53
20melphalan44 50 1111.4TP53, NQO1
21roscovitine449.4CDKN2A, TP53
22bleomycin44 1110.3TP53, NQO1
23flavopiridol44 1110.2CDKN2A, TP53
24thymidine44 2410.2NME1, TP53, PECAM1
25hematoxylin449.1PECAM1, CDKN2A
26crcs449.1TP53, NME1, CDKN2A
27bcnu449.0CDKN2A, TP53, NQO1
28thymidylate448.9CDKN2A, TP53, NQO1
29cytarabine44 50 1110.9NQO1, TP53, CDKN2A
30adriamycin448.9CDKN2A, TP53, NQO1
31daunorubicin44 50 1110.9CDKN2A, NQO1
32camptothecin44 61 1110.9NQO1, TP53, CDKN2A
33arsenite44 249.9CDKN2A, TP53, NQO1
34actinomycin d448.9CDKN2A, TP53, PECAM1
35n acetylcysteine448.9NQO1, TP53, CDKN2A
36doxorubicin44 50 1110.8CDKN2A, TP53, NQO1
37creatinine448.8NQO1, NME1, CDKN2A
38aspartate448.7CDKN2A, NME1, NQO1
39paraffin448.6CDKN2A, NME1, TP53, PECAM1
40vegf448.6PECAM1, TP53, NME1, CDKN2A
41retinoic acid44 249.5CDKN2A, NME1, TP53, PECAM1
425fluorouracil448.5CDKN2A, NME1, TP53, NQO1
43agar448.5CDKN2A, NME1, NQO1, PECAM1
44cisplatin44 50 61 1111.5NQO1, TP53, NME1, CDKN2A
45cycloheximide448.4PECAM1, NQO1, TP53, CDKN2A
46h2o2448.4CDKN2A, TP53, NQO1, PECAM1
47cysteine448.4PECAM1, NQO1, NME1, CDKN2A
48progesterone44 28 61 24 1112.4CDKN2A, NME1, TP53
49estrogen448.0PECAM1, NQO1, TP53, NME1, CDKN2A
50serine447.9PECAM1, NQO1, TP53, NME1, CDKN2A

GO Terms for genes affiliated with Anal Canal Carcinoma

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Cellular components related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166048.8CDKN2A, TP53
2cytosolGO:0058297.6CDKN2A, GLI1, NME1, TP53, NQO1

Biological processes related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to drugGO:0356909.4NME1, TP53
2positive regulation of neuron apoptotic processGO:0435259.4TP53, NQO1
3replicative senescenceGO:0903999.3CDKN2A, TP53
4positive regulation of cell cycle arrestGO:0711589.2CDKN2A, TP53
5Ras protein signal transductionGO:0072659.1CDKN2A, TP53
6negative regulation of cell proliferationGO:0082858.7TP53, NME1, CDKN2A
7positive regulation of transcription, DNA-templatedGO:0458938.4CDKN2A, GLI1, TP53

Molecular functions related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.1CDKN2A, TP53
2p53 bindingGO:0020398.8TP53, CDKN2A
3protein kinase bindingGO:0199018.6CDKN2A, NME1, TP53
4protein bindingGO:0055157.1CDKN2A, GLI1, NME1, TP53, NQO1, PECAM1

Products for genes affiliated with Anal Canal Carcinoma

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Sources for Anal Canal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet