MCID: ANL011
MIFTS: 47

Anal Canal Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Anal Canal Carcinoma

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Disease Ontology:10 An anal canal cancer that derives from epithelial cells.

MalaCards based summary: Anal Canal Carcinoma, also known as carcinoma of anal canal, is related to leukemia and adenocarcinoma. An important gene associated with Anal Canal Carcinoma is GLI1 (GLI family zinc finger 1), and among its related pathways are Validated targets of C-MYC transcriptional activation and Doxorubicin Pathway, Pharmacokinetics. The compounds slex and 5 aminosalicylic acid have been mentioned in the context of this disorder. Affiliated tissues include skin and prostate, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Anal Canal Carcinoma

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Anal Canal Carcinoma, Aliases & Descriptions:

Name: Anal Canal Carcinoma 10 11
Carcinoma of Anal Canal 10 62
 
Anal Canal and Perianal Gland Carcinoma 10
Anal Canal Cancer 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology10 DOID:6126, DOID:0050688
NCIt40 C7489
SNOMED-CT57 285310000
ICD1027 C21.1

Related Diseases for Anal Canal Carcinoma

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Diseases related to Anal Canal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.2TP53, PECAM1, NQO1, CDKN2A, NME1
2adenocarcinoma30.1CDKN2A, GLI1, NME1, TP53, NQO1, PECAM1
3burns10.2
4prostate adenocarcinoma10.2
5prostatitis10.2
6anal canal squamous cell carcinoma10.2
7anal canal adenocarcinoma10.2
8actinic keratosis10.0TP53
9neuroblastoma10.0NME1, TP53
10breast cancer10.0TP53, NME1
11breast ductal carcinoma10.0TP53, NME1
12laryngeal carcinoma10.0NME1, TP53
13basal cell carcinoma10.0GLI1, TP53
14pancreatic cancer10.0GLI1, NQO1
15carcinoid syndrome10.0GLI1, NQO1
16xeroderma pigmentosum, variant type10.0TP53, NQO1
17gastric adenocarcinoma10.0NME1, GLI1
18lung cancer10.0TP53, CDKN2A
19cervical adenocarcinoma10.0NME1, CDKN2A
20oropharynx cancer10.0CDKN2A, TP53
21transitional cell carcinoma10.0NME1, TP53
22cervical intraepithelial neoplasia10.0NME1, CDKN2A
23li-fraumeni syndrome10.0TP53, CDKN2A
24nasopharynx carcinoma10.0CDKN2A, TP53
25uveal melanoma10.0NME1, CDKN2A
26barrett esophagus/esophageal adenocarcinoma10.0CDKN2A, TP53
27grade iii astrocytoma10.0TP53, CDKN2A
28esophageal cancer10.0TP53, CDKN2A
29brain cancer10.0PECAM1, TP53, GLI1
30oligodendroglioma10.0TP53, CDKN2A
31mesothelioma10.0PECAM1, CDKN2A
32sarcoma10.0GLI1, PECAM1, TP53
33papilloma10.0CDKN2A, TP53
34oral cancer10.0CDKN2A, TP53
35acute lymphoblastic leukemia, childhood10.0CDKN2A, NQO1
36squamous cell carcinoma, head and neck10.0TP53, CDKN2A
37multiple myeloma10.0TP53, CDKN2A
38laryngeal squamous cell carcinoma10.0CDKN2A, TP53, NME1
39malignant glioma10.0CDKN2A, TP53, GLI1
40chronic lymphocytic leukemia10.0PECAM1, TP53
41nasopharyngeal carcinoma10.0NME1, TP53, CDKN2A
42endometrial cancer10.0NME1, CDKN2A, TP53
43cervical cancer, somatic10.0CDKN2A, NME1, TP53
44colorectal cancer10.0CDKN2A, NME1, TP53
45bladder cancer, somatic10.0TP53, CDKN2A
46retinoblastoma10.0NME1, CDKN2A, TP53
47small cell cancer of the lung, somatic10.0TP53, CDKN2A, NQO1
48prostate cancer10.0PECAM1, TP53, GLI1, NQO1
49osteosarcoma, somatic10.0CDKN2A, NME1, GLI1, TP53
50burkitt lymphoma9.9CDKN2A, TP53, NQO1

Graphical network of the top 20 diseases related to Anal Canal Carcinoma:



Diseases related to anal canal carcinoma

Symptoms for Anal Canal Carcinoma

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Drugs & Therapeutics for Anal Canal Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Anal Canal Carcinoma

Search NIH Clinical Center for Anal Canal Carcinoma

Genetic Tests for Anal Canal Carcinoma

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Anatomical Context for Anal Canal Carcinoma

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MalaCards organs/tissues related to Anal Canal Carcinoma:

33
Skin, Prostate

Animal Models for Anal Canal Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Anal Canal Carcinoma:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4CDKN2A, GLI1, TP53, PECAM1
2MP:00053818.4PECAM1, TP53, GLI1, CDKN2A
3MP:00053798.2CDKN2A, GLI1, NME1, TP53
4MP:00107718.0NQO1, TP53, NME1, CDKN2A
5MP:00020068.0CDKN2A, GLI1, NME1, TP53, NQO1
6MP:00053807.9TP53, NME1, GLI1, CDKN2A
7MP:00053707.9PECAM1, NQO1, TP53, NME1, CDKN2A
8MP:00053977.8PECAM1, NQO1, TP53, NME1, CDKN2A
9MP:00053847.8PECAM1, NQO1, TP53, GLI1, CDKN2A
10MP:00053787.8NQO1, TP53, NME1, GLI1, CDKN2A
11MP:00053767.6CDKN2A, NME1, TP53, NQO1, PECAM1

Publications for Anal Canal Carcinoma

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Articles related to Anal Canal Carcinoma:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Intensity-Modulated Radiotherapy (IMRT) vs Helical Tomotherapy (HT) in Concurrent Chemoradiotherapy (CRT) for Patients with Anal Canal Carcinoma (ACC): an analysis of dose distribution and toxicities. (25903798)
2015
2
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (24243447)
2014
3
Management of persistent anal canal carcinoma after combined-modality therapy: a clinical review. (24472223)
2014
4
Benefit of MRI scanning in the pretreatment assessment of anal canal carcinoma. (24674573)
2013
5
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (23674135)
2013
6
Light microscopic observation on phagocytosis of Candida spp. blastospores by Trichomonas vaginalis in a patient with anal canal carcinoma. (21395883)
2012
7
Chemotherapy in the treatment of anal canal carcinoma. (22658644)
2012
8
Endobronchial metastases of anal canal carcinoma. (22055765)
2012
9
Twenty-year experience in the management of squamous cell anal canal carcinoma with interstitial brachytherapy. (21775274)
2011
10
Results of salvage abdominoperineal resection after failed chemoradiation therapy for epidermoid anal canal carcinoma: Retrospective analysis at a single institution. (22331724)
2011
11
Anal canal carcinoma treatment results: the experience of a single institution. (21403412)
2011
12
Mitomycin-C- or cisplatin-based chemoradiotherapy for anal canal carcinoma: long-term results. (20472349)
2011
13
Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma. (20492729)
2010
14
Molecular biomarkers correlate with disease-free survival in patients with anal canal carcinoma treated with chemoradiation. (19399614)
2010
15
Conformal external beam radiotherapy in the treatment of anal canal carcinoma: a retrospective study of a genital organ sparing technique. (19695047)
2009
16
Induction therapy for poor-prognosis anal canal carcinoma: a phase II study of the cancer and Leukemia Group B (CALGB 9281). (18490648)
2008
17
Radiochemotherapy of locally advanced anal canal carcinoma: prospective assessment of early impact on the quality of life (randomized trial ACCORD 03). (18191265)
2008
18
Radiotherapy and chemotherapy in the conservative treatment of anal canal carcinoma. (18505075)
2008
19
Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans. (18005443)
2007
20
The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas. (18060184)
2007
21
Anal canal carcinoma with Pagetoid spread: report of a case. (16794808)
2006
22
Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: a retrospective study. (16631268)
2006
23
Epidermal growth factor receptor expression in anal canal carcinoma. (15923158)
2005
24
Anal canal carcinoma: early-stage tumors < or =10 mm (T1 or Tis): therapeutic options and original pattern of local failure after radiotherapy. (15890590)
2005
25
Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of results and radiation dose effectiveness. (15752894)
2005
26
Contribution of conformal therapy in the treatment of anal canal carcinoma with combined chemotherapy and radiotherapy: results of a phase II study. (12788191)
2003
27
Analysis of a follow-up program for anal canal carcinoma. (11484975)
2001
28
Prognostic impact of CD31 antigen expression in anal canal carcinoma. (11677963)
2001
29
Intracavitary afterloading boost in anal canal carcinoma. Results, function and quality of life. (11398611)
2001
30
The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy. (11395235)
2001
31
nm23-H1 protein expression in anal canal carcinoma: does it correlate with prognosis? (10914829)
2000
32
An unusual late radiotherapy-related complication requiring surgery in anal canal carcinoma. (10914830)
2000
33
Immunohistochemical assessment of Ki-67 as prognostic cellular proliferation marker in anal canal carcinoma. (11277325)
2000
34
Treatment of squamous cell anal canal carcinoma with pulsed dose rate brachytherapy. Feasibility study of a French cooperative group. (10435803)
1999
35
Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma. (10523705)
1999
36
Human papillomavirus infection and p53 nuclear overexpression in anal canal carcinoma. (10374676)
1999
37
Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C. (9788412)
1998
38
Role of dose intensity in conservative treatment of anal canal carcinoma. Report of 35 cases. (9778618)
1998
39
Sphincter preservation with chemoradiation in anal canal carcinoma: abdominoperineal resection in selected cases? (9559628)
1998
40
Epidermoid anal canal carcinoma metastatic to the skin. A clinical mimic of prostate adenocarcinoma metastases. (7962940)
1994
41
Late recurrence following treatment of anal canal carcinoma. (1712526)
1991
42
Feasibility of non-surgical definitive management of anal canal carcinoma. (3384732)
1988
43
Our experience of conservative treatment of anal canal carcinoma combining external irradiation and interstitial implant: 32 cases treated between 1973 and 1982. (3338946)
1988
44
Feasibility of non-surgical definitive management of anal canal carcinoma. (3104242)
1987
45
Recurrent deletions of chromosomes 11q and 3p in anal canal carcinoma. (3570551)
1987
46
Treatment of anal canal carcinoma. (3919927)
1985
47
Results and toxicity of the treatment of anal canal carcinoma by radiation therapy or radiation therapy and chemotherapy. (6435851)
1984
48
Radiation therapy and chemotherapy in the treatment of primary anal canal carcinoma. (6831854)
1983
49
Definitive treatment of anal-canal carcinoma by means of radiation therapy and chemotherapy. (6813084)
1982
50
Primary radiation therapy in the treatment of anal canal carcinoma. (7172946)
1982

Variations for Anal Canal Carcinoma

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Expression for genes affiliated with Anal Canal Carcinoma

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Search GEO for disease gene expression data for Anal Canal Carcinoma.

Pathways for genes affiliated with Anal Canal Carcinoma

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Compounds for genes affiliated with Anal Canal Carcinoma

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Compounds related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1slex459.9NME1, PECAM1
25 aminosalicylic acid459.9NQO1, PECAM1
317-(allylamino)-17-demethoxygeldanamycin459.8NQO1, NME1
4dicoumarol459.5NQO1, TP53
5aristolochic acid45 310.5NQO1, TP53
63,3-diindolylmethane459.5NQO1, TP53
7acnu459.5CDKN2A, TP53
8fluorouracil51 1310.5NQO1, TP53
9hpvs459.4CDKN2A, TP53
105-methylcytosine45 2610.4TP53, CDKN2A
11olomoucine45 1310.4TP53, CDKN2A
12indole-3-carbinol459.4TP53, NQO1
13hematoxylin459.4PECAM1, CDKN2A
14temozolomide45 1310.4CDKN2A, TP53
15aflatoxin b145 2610.4TP53, CDKN2A
16hmba459.4TP53, CDKN2A
17benzo(a)pyrene459.4NQO1, TP53
18o6-methylguanine459.4CDKN2A, TP53
19oxaliplatin45 51 1311.3TP53, NQO1
20depsipeptide459.3CDKN2A, TP53
21roscovitine459.3CDKN2A, TP53
22daunorubicin45 51 1311.2CDKN2A, NQO1
23melphalan45 51 1311.2TP53, NQO1
24flavopiridol45 1310.1CDKN2A, TP53
25bleomycin45 1310.1TP53, NQO1
26creatinine459.1NQO1, NME1, CDKN2A
27aspartate459.1CDKN2A, NME1, NQO1
28crcs459.1TP53, NME1, CDKN2A
29thymidine45 2610.0NME1, TP53, PECAM1
30bcnu459.0CDKN2A, TP53, NQO1
31thymidylate458.9CDKN2A, TP53, NQO1
32cytarabine45 51 1310.9NQO1, TP53, CDKN2A
33adriamycin458.9CDKN2A, TP53, NQO1
34camptothecin45 61 1310.9NQO1, TP53, CDKN2A
35arsenite45 269.9CDKN2A, TP53, NQO1
36agar458.9CDKN2A, NME1, NQO1, PECAM1
37n acetylcysteine458.9NQO1, TP53, CDKN2A
38actinomycin d458.9CDKN2A, TP53, PECAM1
39doxorubicin45 51 1310.8CDKN2A, TP53, NQO1
40cysteine458.8PECAM1, NQO1, NME1, CDKN2A
41paraffin458.6CDKN2A, NME1, TP53, PECAM1
42vegf458.6PECAM1, TP53, NME1, CDKN2A
435fluorouracil458.6CDKN2A, NME1, TP53, NQO1
44cisplatin45 51 61 1311.5NQO1, TP53, NME1, CDKN2A
45retinoic acid45 269.5CDKN2A, NME1, TP53, PECAM1
46cycloheximide458.5PECAM1, NQO1, TP53, CDKN2A
47h2o2458.5CDKN2A, TP53, NQO1, PECAM1
48progesterone45 30 61 26 1312.3CDKN2A, NME1, TP53
49estrogen458.1PECAM1, NQO1, TP53, NME1, CDKN2A
50serine458.1PECAM1, NQO1, TP53, NME1, CDKN2A

GO Terms for genes affiliated with Anal Canal Carcinoma

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Cellular components related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166048.7CDKN2A, TP53
2cytosolGO:00058297.7CDKN2A, GLI1, NME1, TP53, NQO1

Biological processes related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of neuron apoptotic processGO:00435259.2TP53, NQO1
2replicative senescenceGO:00903999.2CDKN2A, TP53
3positive regulation of cell cycle arrestGO:00711589.1CDKN2A, TP53
4cellular response to drugGO:00356909.1NME1, TP53
5Ras protein signal transductionGO:00072659.0CDKN2A, TP53
6negative regulation of cell proliferationGO:00082858.6TP53, NME1, CDKN2A
7positive regulation of transcription, DNA-templatedGO:00458938.4CDKN2A, GLI1, TP53

Molecular functions related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:00973719.0CDKN2A, TP53
2p53 bindingGO:00020398.7TP53, CDKN2A
3protein kinase bindingGO:00199018.5CDKN2A, NME1, TP53
4protein bindingGO:00055157.3CDKN2A, GLI1, NME1, TP53, NQO1, PECAM1

Products for genes affiliated with Anal Canal Carcinoma

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Sources for Anal Canal Carcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet