MCID: ANL011
MIFTS: 41

Anal Canal Carcinoma malady

Cancer, Endocrine categories

Summaries for Anal Canal Carcinoma

Sources:
8Disease Ontology, 47OMIM, 33MalaCards
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Disease Ontology:8 A carcinoma that is manifested in the anal canal.

MalaCards: Anal Canal Carcinoma, also known as carcinoma of anal canal, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Anal Canal Carcinoma is ANC (Anal canal carcinoma), and among its related pathways are HIF1Alpha Pathway and TP53 network. The compounds paraffin and slex have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and prostate, and related mouse phenotypes are tumorigenesis and integument.

Description from OMIM:47 105580

Aliases & Classifications for Anal Canal Carcinoma

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 61UMLS, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Aliases & Descriptions:

anal canal carcinoma 8 9 47
carcinoma of anal canal 8 61
anal canal and perianal gland carcinoma 8
anal canal cancer 8


External Ids:

Disease Ontology8 DOID:6126, DOID:0050688
OMIM47 105580
SNOMED-CT57 285310000
NCIt40 C7489
ICD1025 C21.1

Related Diseases for Anal Canal Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Anal Canal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.6NQO1, GLI1, CDKN2A, NME1, PECAM1, TP53
2adenocarcinoma30.2NQO1, GLI1, CDKN2A, NME1, PECAM1, TP53
3anal canal squamous cell carcinoma10.4
4anal squamous cell carcinoma10.4
5anal canal adenocarcinoma10.2
6skin melanoma10.0NME1
7basal cell carcinoma10.0GLI1
8smooth muscle tumor10.0NME1
9leukoplakia10.0NME1
10angiosarcoma10.0PECAM1
11hemangioma10.0PECAM1
12nevoid basal cell carcinoma syndrome10.0GLI1
13lichen planus10.0PECAM1
14peritonitis10.0PECAM1
15acute leukemia10.0NQO1
16fibrosarcoma10.0NQO1
17colon adenocarcinoma10.0NQO1
18pancreatitis10.0NQO1
19hepatoblastoma10.0NQO1
20keratoacanthoma10.0NME1
21anaplastic oligodendroglioma10.0CDKN2A
22kidney cancer10.0TP53
23gallbladder cancer10.0TP53
24leiomyosarcoma10.0TP53
25ulcerative colitis10.0TP53
26nijmegen breakage syndrome10.0NQO1
27benign mesothelioma10.0TP53
28cervical adenocarcinoma10.0NME1, CDKN2A
29cervical intraepithelial neoplasia10.0NME1, CDKN2A
30acute monocytic leukemia10.0NME1
31neuroblastoma10.0NME1, TP53
32actinic keratosis10.0TP53
33laryngeal carcinoma10.0NME1, TP53
34intraocular melanoma10.0NME1, CDKN2A
35lynch syndrome10.0TP53
36breast cancer, invasive ductal10.0NME1, TP53
37xeroderma pigmentosum10.0TP53, NQO1
38bladder carcinoma10.0TP53, CDKN2A
39oropharyngeal cancer, adult10.0TP53, CDKN2A
40lung cancer10.0CDKN2A, TP53
41oligodendroglioma10.0TP53, CDKN2A
42li-fraumeni syndrome10.0CDKN2A, TP53
43astrocytoma10.0TP53, CDKN2A
44nasopharynx carcinoma10.0TP53, CDKN2A
45skin cancer10.0TP53, CDKN2A
46sarcoma10.0GLI1, PECAM1, TP53
47barrett's esophagus10.0CDKN2A, TP53
48bladder carcinoma in situ10.0TP53, CDKN2A
49brain cancer10.0TP53, PECAM1, GLI1
50malignant glioma10.0GLI1, CDKN2A, TP53

Graphical network of the top 20 diseases related to Anal Canal Carcinoma:



Diseases related to anal canal carcinoma

Clinical Features for Anal Canal Carcinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

105580

Drugs & Therapeutics for Anal Canal Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Anal Canal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Anal Canal Carcinoma

Search NIH Clinical Center for Anal Canal Carcinoma

Search CenterWatch for Anal Canal Carcinoma

Genetic Tests for Anal Canal Carcinoma

Anatomical Context for Anal Canal Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anal Canal Carcinoma:

33
Skin, Lymph node, Prostate, B cells

Animal Models for Anal Canal Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Anal Canal Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.6CDKN2A, TP53, NME1, NQO1, GLI1
2MP:00107717.6NQO1, CDKN2A, NME1, NBL1, TP53
3MP:00053707.3CDKN2A, NME1, PECAM1, TP53, NQO1

Publications for Anal Canal Carcinoma

Sources:
51PubMed
See all sources

Articles related to Anal Canal Carcinoma:

(show top 50)    (show all 84)
idTitleAuthorsYear
1
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (24243447)
2014
2
Reply to phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (24243421)
2014
3
Education and Imaging. Gastrointestinal: advanced untreated anal canal squamous cell carcinoma. (23692575)
2013
4
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (23674135)
2013
5
Light microscopic observation on phagocytosis of Candida spp. blastospores by Trichomonas vaginalis in a patient with anal canal carcinoma. (21395883)
2012
6
Extrapulmonary small cell carcinoma of the anal canal: a case report and review of the literature. (22454644)
2012
7
Chemotherapy in the treatment of anal canal carcinoma. (22658644)
2012
8
Induction chemotherapy and dose intensification of the radiation boost in locally advanced anal canal carcinoma: final analysis of the randomized UNICANCER ACCORD 03 trial. (22529257)
2012
9
Twenty-year experience in the management of squamous cell anal canal carcinoma with interstitial brachytherapy. (21775274)
2011
10
Results of salvage abdominoperineal resection after failed chemoradiation therapy for epidermoid anal canal carcinoma: Retrospective analysis at a single institution. (22331724)
2011
11
Anal canal carcinoma treatment results: the experience of a single institution. (21403412)
2011
12
Mitomycin-C- or cisplatin-based chemoradiotherapy for anal canal carcinoma: long-term results. (20472349)
2011
13
Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma. (20492729)
2010
14
Conformal external beam radiotherapy in the treatment of anal canal carcinoma: a retrospective study of a genital organ sparing technique. (19695047)
2009
15
An unusual case of small cell carcinoma of the anal canal. (23061097)
2009
16
Chemotherapy and radiotherapy for anal canal carcinoma. (18812528)
2008
17
Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans. (18005443)
2007
18
External beam radiotherapy plus brachytherapy boost in treatment of anal canal carcinoma. (17988027)
2007
19
F-18 FDG PET/CT imaging of anal canal squamous cell carcinoma. (17314608)
2007
20
Anal canal carcinoma with Pagetoid spread: report of a case. (16794808)
2006
21
Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: a retrospective study. (16631268)
2006
22
Epidermal growth factor receptor expression in anal canal carcinoma. (15923158)
2005
23
Risk factors for carcinoma of the pelvic ileal pouch/anal canal in ulcerative colitis. (15228225)
2004
24
Mucoepidermoid carcinoma of the anal canal: an immunohistochemical study. (11480798)
2001
25
Intracavitary afterloading boost in anal canal carcinoma. Results, function and quality of life. (11398611)
2001
26
The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy. (11395235)
2001
27
An unusual late radiotherapy-related complication requiring surgery in anal canal carcinoma. (10914830)
2000
28
Patterns of recurrence in anal canal carcinoma. (10982516)
2000
29
Treatment of squamous cell anal canal carcinoma with pulsed dose rate brachytherapy. Feasibility study of a French cooperative group. (10435803)
1999
30
Correlation between nm23-H1 overexpression and clinicopathological variables in human anal canal carcinoma. (10523705)
1999
31
Overexpression of p53 protein and outcome of patients treated with chemoradiation for carcinoma of the anal canal: a report of randomized trial RTOG 87-04. Radiation Therapy Oncology Group. (10189126)
1999
32
Prognostic role of p53 protein expression in epidermoid carcinoma of the anal canal. (10487550)
1999
33
The prevalence of p53 immunoreactivity in anal canal carcinoma. (9769387)
1998
34
Role of dose intensity in conservative treatment of anal canal carcinoma. Report of 35 cases. (9778618)
1998
35
Treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil-cisplatinum. Long-term results in 95 patients. (9572617)
1998
36
Correlation between human papillomavirus infection and clinicopathological parameters in anal canal carcinoma. (21590048)
1997
37
Epidermoid anal canal carcinoma metastatic to the skin. A clinical mimic of prostate adenocarcinoma metastases. (7962940)
1994
38
Mitomycin in anal canal carcinoma. (8483559)
1993
39
Anal canal carcinoma: a historical account. (1935472)
1991
40
Feasibility of non-surgical definitive management of anal canal carcinoma. (3384732)
1988
41
Our experience of conservative treatment of anal canal carcinoma combining external irradiation and interstitial implant: 32 cases treated between 1973 and 1982. (3338946)
1988
42
Feasibility of non-surgical definitive management of anal canal carcinoma. (3104242)
1987
43
Recurrent deletions of chromosomes 11q and 3p in anal canal carcinoma. (3570551)
1987
44
Results and toxicity of the treatment of anal canal carcinoma by radiation therapy or radiation therapy and chemotherapy. (6435851)
1984
45
Radiation therapy and chemotherapy in the treatment of primary anal canal carcinoma. (6831854)
1983
46
Definitive treatment of anal-canal carcinoma by means of radiation therapy and chemotherapy. (6813084)
1982
47
Primary radiation therapy in the treatment of anal canal carcinoma. (7172946)
1982
48
Difficulties with the diagnosis of linitis plastica carcinoma of the rectum and anal canal. (1272144)
1976
49
Transitional-cell cloacogenic carcinoma of the anal canal: Case report. (1159269)
1975
50
Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum: report of seven cases. (5172130)
1971

Genetic Variations for Anal Canal Carcinoma

Expression for genes affiliated with Anal Canal Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anal Canal Carcinoma

Search GEO for disease gene expression data for Anal Canal Carcinoma.

Pathways for genes affiliated with Anal Canal Carcinoma

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0TP53, CDKN2A
29.0TP53, CDKN2A
39.0TP53, CDKN2A
48.7TP53, CDKN2A, GLI1

Compounds for genes affiliated with Anal Canal Carcinoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1paraffin4510.0PECAM1, NME1
2slex459.8PECAM1, NME1
35 aminosalicylic acid459.8PECAM1, NQO1
417-(allylamino)-17-demethoxygeldanamycin459.7NME1, NQO1
5dicoumarol459.5NQO1, TP53
63,3-diindolylmethane459.5NQO1, TP53
7acnu459.4TP53, CDKN2A
8hpvs459.4TP53, CDKN2A
9olomoucine45 1110.4CDKN2A, TP53
105-methylcytosine45 2410.3CDKN2A, TP53
11temozolomide45 1110.3TP53, CDKN2A
12aflatoxin b145 2410.3CDKN2A, TP53
13hmba459.3CDKN2A, TP53
14o6-methylguanine459.3TP53, CDKN2A
15indole-3-carbinol459.2TP53, NQO1
16depsipeptide459.0CDKN2A, TP53
17crcs459.0TP53, NME1, CDKN2A
18bcnu458.9TP53, CDKN2A, NQO1
19cytarabine45 50 1110.9NQO1, CDKN2A, TP53
20thymidylate458.9TP53, CDKN2A, NQO1
21adriamycin458.9TP53, CDKN2A, NQO1
22camptothecin45 60 1110.9NQO1, CDKN2A, TP53
23agar458.9NQO1, CDKN2A, NME1, PECAM1
24arsenite45 249.9TP53, CDKN2A, NQO1
25n acetylcysteine458.7NQO1, CDKN2A, TP53
26actinomycin d458.6TP53, PECAM1, CDKN2A
275fluorouracil458.5NQO1, CDKN2A, NME1, TP53
28cisplatin45 50 60 1111.5NQO1, CDKN2A, NME1, TP53
29vegf458.4CDKN2A, NME1, PECAM1, TP53
30h2o2458.4NQO1, CDKN2A, PECAM1, TP53
31cysteine458.4PECAM1, NME1, CDKN2A, NQO1
32retinoic acid45 249.2CDKN2A, NME1, PECAM1, TP53
33doxorubicin45 50 1110.2NQO1, CDKN2A, TP53
34serine457.9NQO1, CDKN2A, NME1, PECAM1, TP53

GO Terms for genes affiliated with Anal Canal Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.0TP53, CDKN2A

Biological processes related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to drugGO:0356909.2TP53, NME1
2replicative senescenceGO:0903999.0TP53, CDKN2A
3positive regulation of cell cycle arrestGO:0711588.9TP53, CDKN2A
4positive regulation of neuron apoptotic processGO:0435258.8TP53, NQO1

Molecular functions related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.0TP53, CDKN2A
2MDM2/MDM4 family protein bindingGO:0973718.9TP53, CDKN2A
3protein kinase bindingGO:0199018.3TP53, NME1, CDKN2A

Products for genes affiliated with Anal Canal Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anal Canal Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet