MCID: ANL011
MIFTS: 47

Anal Canal Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Anal Canal Carcinoma

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A carcinoma that is manifested in the anal canal.

MalaCards: Anal Canal Carcinoma, also known as carcinoma of anal canal, is related to squamous cell carcinoma and leukemia. An important gene associated with Anal Canal Carcinoma is ANC (Anal canal carcinoma), and among its related pathways are HIF1Alpha Pathway and TP53 network. The compounds paraffin and slex have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and prostate, and related mouse phenotypes are tumorigenesis and integument.

Description from OMIM:46 105580

Aliases & Classifications for Anal Canal Carcinoma

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8Disease Ontology, 9diseasecard, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

anal canal carcinoma 8 9 46
carcinoma of anal canal 8 60
anal canal and perianal gland carcinoma 8
anal canal cancer 8


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Disease Ontology8 DOID:6126, DOID:0050688
OMIM46 105580
SNOMED-CT56 285310000
NCIt39 C7489
ICD1025 C21.1

Related Diseases for Anal Canal Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anal Canal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.5NQO1, GLI1, CDKN2A, NME1, PECAM1, TP53
2leukemia30.2NQO1, CDKN2A, NME1, PECAM1, TP53
3adenocarcinoma30.2NQO1, GLI1, CDKN2A, NME1, PECAM1, TP53
4anal canal squamous cell carcinoma10.4
5anal squamous cell carcinoma10.4
6burns10.2
7anal canal adenocarcinoma10.2
8prostate adenocarcinoma10.2
9prostatitis10.2
10skin melanoma10.0NME1
11basal cell carcinoma10.0GLI1
12smooth muscle tumor10.0NME1
13leukoplakia10.0NME1
14angiosarcoma10.0PECAM1
15hemangioma10.0PECAM1
16lichen planus10.0PECAM1
17nevoid basal cell carcinoma syndrome10.0GLI1
18acute leukemia10.0NQO1
19peritonitis10.0PECAM1
20fibrosarcoma10.0NQO1
21colon adenocarcinoma10.0NQO1
22pancreatitis10.0NQO1
23hepatoblastoma10.0NQO1
24keratoacanthoma10.0NME1
25anaplastic oligodendroglioma10.0CDKN2A
26kidney cancer10.0TP53
27gallbladder cancer10.0TP53
28leiomyosarcoma10.0TP53
29ulcerative colitis10.0TP53
30nijmegen breakage syndrome10.0NQO1
31benign mesothelioma10.0TP53
32cervical adenocarcinoma10.0NME1, CDKN2A
33cervical intraepithelial neoplasia10.0NME1, CDKN2A
34acute monocytic leukemia10.0NME1
35neuroblastoma10.0NME1, TP53
36actinic keratosis10.0TP53
37laryngeal benign neoplasm10.0NME1, TP53
38intraocular melanoma10.0NME1, CDKN2A
39lynch syndrome10.0TP53
40breast cancer, invasive ductal10.0NME1, TP53
41xeroderma pigmentosum10.0TP53, NQO1
42bladder carcinoma10.0TP53, CDKN2A
43oropharyngeal cancer, adult10.0TP53, CDKN2A
44lung cancer10.0CDKN2A, TP53
45oligodendroglioma10.0TP53, CDKN2A
46li-fraumeni syndrome10.0CDKN2A, TP53
47astrocytoma10.0TP53, CDKN2A
48nasopharynx carcinoma10.0TP53, CDKN2A
49sarcoma10.0GLI1, PECAM1, TP53
50barrett's esophagus10.0CDKN2A, TP53

Graphical network of the top 20 diseases related to Anal Canal Carcinoma:



Diseases related to anal canal carcinoma

Clinical Features for Anal Canal Carcinoma

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Sources:
46OMIM
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Clinical features from OMIM:

105580

Drugs & Therapeutics for Anal Canal Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Anal Canal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Anal Canal Carcinoma

Search NIH Clinical Center for Anal Canal Carcinoma

Search CenterWatch for Anal Canal Carcinoma

Genetic Tests for Anal Canal Carcinoma

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Anatomical Context for Anal Canal Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Anal Canal Carcinoma:

32
Lymph node, Skin, Prostate

Animal Models for Anal Canal Carcinoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Anal Canal Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.6TP53, NME1, CDKN2A, GLI1, NQO1
2MP:00107717.6TP53, NBL1, NME1, CDKN2A, NQO1
3MP:00053707.3NQO1, CDKN2A, NME1, PECAM1, TP53

Publications for Anal Canal Carcinoma

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50PubMed
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Articles related to Anal Canal Carcinoma:

(show top 50)    (show all 84)
idTitleAuthorsYear
1
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (24243447)
2014
2
Education and Imaging. Gastrointestinal: advanced untreated anal canal squamous cell carcinoma. (23692575)
2013
3
Changing patterns of anal canal carcinoma in the United States. (23509304)
2013
4
Phase 1 study of cetuximab in combination with 5-fluorouracil, cisplatin, and radiotherapy in patients with locally advanced anal canal carcinoma. (23674135)
2013
5
Extrapulmonary small cell carcinoma of the anal canal: a case report and review of the literature. (22454644)
2012
6
Endobronchial metastases of anal canal carcinoma. (22055765)
2012
7
Anal canal neuroendocrine carcinoma associated with squamous intraepithelial neoplasia: a human papillomavirus 18-related lesion. (22524667)
2012
8
The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma: A Case Series. (21772841)
2011
9
Molecular biomarkers correlate with disease-free survival in patients with anal canal carcinoma treated with chemoradiation. (19399614)
2010
10
Post burn Marjolin's ulcer in the natal cleft mimicking anal canal carcinoma: a rare site. (21160444)
2010
11
An unusual case of small cell carcinoma of the anal canal. (23061097)
2009
12
Radiochemotherapy of locally advanced anal canal carcinoma: prospective assessment of early impact on the quality of life (randomized trial ACCORD 03). (18191265)
2008
13
Radiotherapy and chemotherapy in the conservative treatment of anal canal carcinoma. (18505075)
2008
14
Chemotherapy and radiotherapy for anal canal carcinoma. (18812528)
2008
15
Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans. (18005443)
2007
16
Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. (20084726)
2007
17
The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas. (18060184)
2007
18
Evidence of clinical activity for cetuximab combined with irinotecan in a patient with refractory anal canal squamous-cell carcinoma: report of a case. (17252287)
2007
19
F-18 FDG PET/CT imaging of anal canal squamous cell carcinoma. (17314608)
2007
20
Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: a retrospective study. (16631268)
2006
21
Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification. (16648870)
2006
22
Epidermal growth factor receptor expression in anal canal carcinoma. (15923158)
2005
23
Anal canal carcinoma: early-stage tumors < or =10 mm (T1 or Tis): therapeutic options and original pattern of local failure after radiotherapy. (15890590)
2005
24
Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of results and radiation dose effectiveness. (15752894)
2005
25
Risk factors for carcinoma of the pelvic ileal pouch/anal canal in ulcerative colitis. (15228225)
2004
26
Anal canal neuroendocrine carcinoma with Pagetoid extension. (15260855)
2004
27
Contribution of conformal therapy in the treatment of anal canal carcinoma with combined chemotherapy and radiotherapy: results of a phase II study. (12788191)
2003
28
Analysis of a follow-up program for anal canal carcinoma. (11484975)
2001
29
Mucoepidermoid carcinoma of the anal canal: an immunohistochemical study. (11480798)
2001
30
Carcinomas of the anal canal and anal margin differ in their expression of cadherin, cytokeratins and p53. (11787851)
2001
31
Prognostic impact of CD31 antigen expression in anal canal carcinoma. (11677963)
2001
32
Anal canal squamous-cell carcinoma in situ, clearly demonstrated by indigo carmine dye spraying: report of a case. (10950017)
2000
33
nm23-H1 protein expression in anal canal carcinoma: does it correlate with prognosis? (10914829)
2000
34
An unusual late radiotherapy-related complication requiring surgery in anal canal carcinoma. (10914830)
2000
35
Immunohistochemical assessment of Ki-67 as prognostic cellular proliferation marker in anal canal carcinoma. (11277325)
2000
36
Human papillomavirus infection and p53 nuclear overexpression in anal canal carcinoma. (10374676)
1999
37
Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C. (9788412)
1998
38
Treatment of anal canal carcinoma with high dose radiation therapy and concomitant fluorouracil-cisplatinum. Long-term results in 95 patients. (9572617)
1998
39
Late recurrence following treatment of anal canal carcinoma. (1712526)
1991
40
Cloacogenic carcinoma of the anal canal and associated viral lesions. An in situ hybridization study for human papilloma virus. (1657356)
1991
41
Feasibility of non-surgical definitive management of anal canal carcinoma. (3384732)
1988
42
Our experience of conservative treatment of anal canal carcinoma combining external irradiation and interstitial implant: 32 cases treated between 1973 and 1982. (3338946)
1988
43
Feasibility of non-surgical definitive management of anal canal carcinoma. (3104242)
1987
44
Recurrent deletions of chromosomes 11q and 3p in anal canal carcinoma. (3570551)
1987
45
Radiation therapy and chemotherapy in the treatment of primary anal canal carcinoma. (6831854)
1983
46
Primary radiation therapy in the treatment of anal canal carcinoma. (7172946)
1982
47
Difficulties with the diagnosis of linitis plastica carcinoma of the rectum and anal canal. (1272144)
1976
48
Transitional-cell cloacogenic carcinoma of the anal canal: Case report. (1159269)
1975
49
Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum: report of seven cases. (5172130)
1971
50
Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred seventy-three cases. (6058180)
1967

Genetic Variations for Anal Canal Carcinoma

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Expression for genes affiliated with Anal Canal Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anal Canal Carcinoma

Search GEO for disease gene expression data for Anal Canal Carcinoma.

Pathways for genes affiliated with Anal Canal Carcinoma

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0TP53, CDKN2A
29.0TP53, CDKN2A
39.0TP53, CDKN2A
48.7TP53, CDKN2A, GLI1

Compounds for genes affiliated with Anal Canal Carcinoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1paraffin4410.0PECAM1, NME1
2slex449.8PECAM1, NME1
35 aminosalicylic acid449.8PECAM1, NQO1
417-(allylamino)-17-demethoxygeldanamycin449.7NME1, NQO1
5dicoumarol449.5NQO1, TP53
63,3-diindolylmethane449.5NQO1, TP53
7acnu449.4TP53, CDKN2A
8hpvs449.4TP53, CDKN2A
9olomoucine44 1110.4CDKN2A, TP53
105-methylcytosine44 2410.3CDKN2A, TP53
11temozolomide44 1110.3TP53, CDKN2A
12aflatoxin b144 2410.3CDKN2A, TP53
13hmba449.3CDKN2A, TP53
14o6-methylguanine449.3TP53, CDKN2A
15indole-3-carbinol449.2TP53, NQO1
16depsipeptide449.0CDKN2A, TP53
17crcs449.0TP53, NME1, CDKN2A
18bcnu448.9TP53, CDKN2A, NQO1
19cytarabine44 49 1110.9NQO1, CDKN2A, TP53
20thymidylate448.9TP53, CDKN2A, NQO1
21adriamycin448.9TP53, CDKN2A, NQO1
22camptothecin44 59 1110.9NQO1, CDKN2A, TP53
23agar448.9NQO1, CDKN2A, NME1, PECAM1
24arsenite44 249.9TP53, CDKN2A, NQO1
25n acetylcysteine448.7NQO1, CDKN2A, TP53
26actinomycin d448.6TP53, PECAM1, CDKN2A
275fluorouracil448.5NQO1, CDKN2A, NME1, TP53
28cisplatin44 49 59 1111.5NQO1, CDKN2A, NME1, TP53
29vegf448.4CDKN2A, NME1, PECAM1, TP53
30h2o2448.4NQO1, CDKN2A, PECAM1, TP53
31cysteine448.4PECAM1, NME1, CDKN2A, NQO1
32retinoic acid44 249.2CDKN2A, NME1, PECAM1, TP53
33doxorubicin44 49 1110.2NQO1, CDKN2A, TP53
34serine447.9NQO1, CDKN2A, NME1, PECAM1, TP53

GO Terms for genes affiliated with Anal Canal Carcinoma

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16Gene Ontology
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Cellular components related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.0TP53, CDKN2A

Biological processes related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to drugGO:0356909.2TP53, NME1
2replicative senescenceGO:0903999.0TP53, CDKN2A
3positive regulation of cell cycle arrestGO:0711588.9TP53, CDKN2A
4positive regulation of neuron apoptotic processGO:0435258.8TP53, NQO1

Molecular functions related to Anal Canal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.0TP53, CDKN2A
2MDM2/MDM4 family protein bindingGO:0973718.9TP53, CDKN2A
3protein kinase bindingGO:0199018.3TP53, NME1, CDKN2A

Products for genes affiliated with Anal Canal Carcinoma

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  • Antibodies
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  • Antibodies

Sources for Anal Canal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet