MCID: ANL022
MIFTS: 39

Anal Fistula malady

Gastrointestinal diseases, Rare diseases categories

Summaries for Anal Fistula

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Wikipedia:63 Anal fistula, or fistula-in-ano, is a chronic abnormal communication between the epithelialised surface... more...

MalaCards based summary: Anal Fistula, also known as anorectal fistula, is related to adenocarcinoma and crohn's disease. An important gene associated with Anal Fistula is MLH1 (mutL homolog 1), and among its related pathways are DNA damage Role of Brca1 and Brca2 in DNA repair and Telomere C-strand (Lagging Strand) Synthesis. The compounds n-methyl-n-nitrosourea and mononucleotide have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and small intestine, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Anal Fistula

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Sources:
30LifeMap Discovery®, 47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Anal Fistula, Aliases & Descriptions:

Name: Anal Fistula 30 47
 
Anorectal Fistula 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

47
anal fistula:
Prevalence: 1-5/10000 (Europe)


External Ids:

Orphanet47 228113
ICD10 via Orphanet26 K60.3
UMLS via Orphanet61 C0205929
ICD1025 K60.3, K60.5

Related Diseases for Anal Fistula

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Diseases related to Anal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma29.8MSH2, KRT7, KRT20, MLH1, MMP9, EGF
2crohn's disease10.5
3peri-anal fistula10.5
4intestinal obstruction10.4ALB
5sebaceous adenoma10.4MSH2
6mucinous adenocarcinoma10.4
7bladder adenocarcinoma10.3KRT20, KRT7
8mammary paget's disease10.3KRT7, KRT20
9signet ring cell adenocarcinoma10.3KRT7, KRT20
10ovarian brenner tumor10.3KRT20, KRT7
11mucinous cystadenocarcinoma10.3KRT20, KRT7
12paget disease, extramammary10.3KRT20, KRT7
13pancreatic ductal carcinoma10.3KRT7, KRT20
14tuberculosis10.3
15pseudomyxoma peritonei10.3KRT7, KRT20
16bronchiolo-alveolar adenocarcinoma10.3KRT20, KRT7
17cervical adenocarcinoma10.3KRT7, KRT20
18tubular adenocarcinoma10.3KRT7, KRT20
19meningioma, familial10.3EGF
20abrikosov's tumor10.3KRT7, KRT20
21adenosquamous carcinoma10.3KRT7, KRT20
22large cell carcinoma10.3KRT7, KRT20
23salivary gland adenoid cystic carcinoma10.3KRT7, KRT20
24oxyphilic adenoma10.3KRT7, KRT20
25neuroendocrine tumor10.3KRT7, KRT20
26gallbladder cancer10.2KRT7, MLH1
27barrett esophagus/esophageal adenocarcinoma10.2KRT7, KRT20
28muir-torre syndrome10.2MLH1, MSH2
29keratoacanthoma10.2MSH2, MLH1
30currarino syndrome10.2
31histiocytosis10.2
32mismatch repair cancer syndrome10.2MSH2, MLH1
33mesothelioma, somatic10.2KRT7, KRT20
34lynch syndrome10.2MLH1, MSH2
35basal cell carcinoma10.2KRT20, KRT7, S100A7
36mesothelioma10.2KRT7, KRT20
37neurofibromatosis10.1MLH1, MSH2
38brain edema10.1MMP9, ALB
39cholangiocarcinoma10.1KRT20, KRT7
40gastric adenocarcinoma10.1MLH1, KRT7, KRT20
41bladder cancer, somatic10.1MMP9, KRT20
42gastrointestinal carcinoma10.1EGF, KRT20
43rectal neoplasm10.1MLH1, MSH2, KRT20
44skin disease10.1MMP9, ALB
45obesity10.1
46arthritis10.1
47langerhans-cell histiocytosis10.1
48pulmonary tuberculosis10.1
49tuberculous epididymitis10.1
50hidradenitis suppurativa10.1

Graphical network of the top 20 diseases related to Anal Fistula:



Diseases related to anal fistula

Symptoms for Anal Fistula

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Drugs & Therapeutics for Anal Fistula

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Drug clinical trials:

Search ClinicalTrials for Anal Fistula

Search NIH Clinical Center for Anal Fistula

Genetic Tests for Anal Fistula

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Anatomical Context for Anal Fistula

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MalaCards organs/tissues related to Anal Fistula:

31
Skin, Colon, Small intestine

Animal Models for Anal Fistula or affiliated genes

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MGI Mouse Phenotypes related to Anal Fistula:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0ALB, MSH2, MMP9, MLH1
2MP:00053818.3EGF, ALB, MSH2, MMP9, MLH1

Publications for Anal Fistula

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Articles related to Anal Fistula:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Overview of anal fistula and systematic review of ligation of the intersphincteric fistula tract (LIFT). (23893217)
2014
2
Video-assisted anal fistula treatment. (25419106)
2014
3
The role of loose seton in the management of anal fistula: a multicenter study of 200 patients. (24989839)
2014
4
Effectiveness of the ligation of intersphincteric fistula tract (LIFT) in the treatment of anal fistula: initial results. (25004286)
2014
5
Long-term outcome of the anal fistula plug for anal fistula of cryptoglandular origin. (23981140)
2013
6
The OTSCAr Proctology clip system for anal fistula closure: first prospective clinical data. (23971828)
2013
7
Is the placement of the new synthetic anal fistula plug really so ineffective? (22513443)
2012
8
Collagen matrix injection combined with flap repair for complex anal fistula. (23136821)
2012
9
Why do we have so much trouble treating anal fistula? (21876616)
2011
10
The efficacy of anal fistula plug in fistula-in-ano: a systematic review. (19438881)
2010
11
Outcomes of anal fistula surgery in patients with inflammatory bowel disease. (20466103)
2010
12
Successful treatment of an enterocutaneous fistula with an anal fistula plug after an abdominal stab wound. (20171563)
2010
13
Anal fistula with a tuberculous origin. (20221764)
2010
14
Randomized clinical trial of anal fistula plug versus endorectal advancement flap for the treatment of high cryptoglandular fistula in ano (Br J Surg 2009; 96: 608-612). (19591140)
2009
15
Core out fistulectomy, anal sphincter reconstruction and primary repair of internal opening in the treatment of complex anal fistula. (19459524)
2009
16
A case of langerhans cell histiocytosis with anal fistula. (20505285)
2009
17
Surgical treatment of complex anal fistulas with the anal fistula plug: a prospective, multicenter study. (19690485)
2009
18
Anal fistula: an unusual presentation of tuberculosis in a migrant health care professional. (18830735)
2009
19
Efficacy of the anal fistula plug in complex anorectal fistulae. (18637922)
2009
20
Anal fistula plug in high fistula-in-ano: an early Saudi experience. (19690486)
2009
21
To determine the efficacy of anal fistula plug in the treatment of high fistula-in-ano: an initial experience. (18637937)
2009
22
Haemorrhoids, rectal prolapse, anal fissure, peri-anal fistulae and sexually transmitted diseases. (19647691)
2009
23
Adenocarcinoma of the rectosigmoid colon seeding into pre-existing anal fistula. (18705305)
2008
24
Early experience with the bioabsorbable anal fistula plug. (18373120)
2008
25
Microbiological analysis and endoanal ultrasonography for diagnosis of anal fistula in acute anorectal sepsis. (16601946)
2007
26
Evaluation of the use of BioGlue in the treatment of high anal fistulas: preliminary results of a pilot study. (17164962)
2007
27
Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. (17082891)
2006
28
Randomized clinical trial of local gentamicin-collagen treatment in advancement flap repair for anal fistula. (16952209)
2006
29
Efficacy of anal fistula plug in closure of Crohn's anorectal fistulas. (16998638)
2006
30
Mucinous adenocarcinoma associated with chronic anal fistula reconstructed by gracilis myocutaneous flaps. (16969607)
2006
31
Cancer in the anal canal, and in an anal fistula, that developed during a longstanding course of Crohn's disease. (16261439)
2005
32
Internal anal sphincter preservation with seton rerouting in high transsphincteric anal fistula. (15937616)
2005
33
Radiofrequency fistulotomy: a better alternative for treating low anal fistula. (15543373)
2004
34
Radio frequency fistulotomy--novel modification of the conventional technique in low anal fistula. (15225449)
2004
35
Radio frequency fistulotomy--a novel modification of the conventional technique in low anal fistula. (15346801)
2004
36
Complex anal fistula surgery: personal experience. (15452991)
2004
37
Anal lesion resulting from implantation of viable tumour cells in a pre-existing anal fistula. A case report. (12136546)
2002
38
Combined seton-double flap procedure for complex high anal fistula. (12077648)
2002
39
A calculus within an anal fistula tract in a diabetic patient. (11299415)
2001
40
Cow's milk-protein allergy as a cause of anal fistula and fissures: a case report. (9449512)
1998
41
Post operative wound healing with kshaarasutra - a new approach in high anal fistula. (22556730)
1995
42
Anal fistula. (1555083)
1992
43
Congenital anal fistula with normal anus. (2724010)
1989
44
Use of hydrogen peroxide to identify internal opening of anal fistula and perianal abscess. (3459454)
1986
45
Anal fistula: a review of 82 cases. (1248349)
1976
46
Colloid carcinoma arising in an anal fistula: case report with a brief review of the literature. (168847)
1975
47
Carcinoma arising in anal fistula. (6073791)
1967
48
Hidradenitis suppurativa; its confusion with pilonidal disease and anal fistula. (18111693)
1949
49
Experiences in primary closure following excision of anal fistula. (18879182)
1948
50
Is anal fistula a necessary sequel to perianal abscess? (18899254)
1948

Variations for Anal Fistula

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Expression for genes affiliated with Anal Fistula

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Search GEO for disease gene expression data for Anal Fistula.

Pathways for genes affiliated with Anal Fistula

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Pathways related to Anal Fistula according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MSH2, MLH1
2
Show member pathways
9.8MSH2, MLH1
3
Show member pathways
Catalytic cycle of mammalian FMOs36
9.8MSH2, MLH1
4
Show member pathways
9.8MSH2, MLH1
5
Show member pathways
Signal transduction PTEN pathway58
9.4MLH1, MSH2, EGF
69.0EGF, MSH2, MMP9, MLH1
79.0EGF, MSH2, MMP9, MLH1

Compounds for genes affiliated with Anal Fistula

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Compounds related to Anal Fistula according to GeneCards Suite gene sharing:

(show all 45)
idCompoundScoreTop Affiliating Genes
1n-methyl-n-nitrosourea4310.2MSH2, MLH1
2mononucleotide4310.2MSH2, MLH1
36 thioguanine4310.2MLH1, MSH2
4mnng4310.1MLH1, MSH2
5temozolomide43 1211.1MSH2, MLH1
6trapidil4310.1EGF, MMP9
7ilomastat4310.1MMP9, EGF
8o6-methylguanine4310.1MSH2, MLH1
9gelfoam4310.0ALB, MMP9
10fosinopril43 1211.0MMP9, ALB
11crcs4310.0MLH1, MSH2
12sucralfate43 1211.0ALB, EGF
13irbesartan43 28 49 1213.0ALB, MMP9
14sulindac43 1210.9ALB, MLH1
15erlotinib43 49 1211.8EGF, ALB
165fluorouracil439.7EGF, MSH2, MLH1
17ivig439.7ALB, MMP9
18irinotecan43 49 1211.7MLH1, ALB, EGF
19folate439.7ALB, MMP9, MLH1
20mucicarmine439.7KRT20, KRT7
21gefitinib43 49 1211.7MMP9, ALB, EGF
22celecoxib43 59 28 49 24 1214.6ALB, MMP9
23b 723439.6KRT20, KRT7
24streptavidin439.6KRT20, KRT7
25proline439.5MSH2, MMP9, MLH1
26hyaluronic acid43 2410.5KRT20, ALB, MMP9
27lactose43 1210.5MMP9, KRT7
28hematoxylin439.4MMP9, KRT7, KRT20
29methotrexate49 43 1211.4KRT7, ALB, MMP9
30matrigel439.4EGF, KRT7, MMP9
31formaldehyde43 2410.3MMP9, KRT7, KRT20
32doxorubicin43 49 1211.3EGF, KRT20, MSH2, MLH1
33alanine439.3MLH1, MMP9, MSH2, ALB
34vitamin a43 24 1211.1KRT7, ALB, MMP9, MLH1
35cisplatin43 49 59 1212.1EGF, MSH2, MLH1
36fatty acid439.1S100A7, ALB, MLH1
37progesterone43 28 59 24 1213.0MLH1, KRT7, KRT20, EGF
38iron43 2410.0KRT20, KRT7, ALB, MLH1
39paraffin438.7KRT20, KRT7, MSH2, MMP9, MLH1
40vegf438.7EGF, KRT20, KRT7, MMP9, MLH1
41retinoic acid43 249.6EGF, KRT7, S100A7, MMP9, MLH1
42calcium43 49 24 1211.5MLH1, MMP9, ALB, S100A7, EGF
43tyrosine438.5MLH1, MMP9, KRT7, KRT20, EGF
44testosterone43 59 24 1211.5MMP9, ALB, KRT7, KRT20, EGF
45estrogen438.1MLH1, MMP9, S100A7, KRT7, KRT20, EGF

GO Terms for genes affiliated with Anal Fistula

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Cellular components related to Anal Fistula according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6EGF, ALB

Biological processes related to Anal Fistula according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00062989.8MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:00164469.7MSH2, MLH1
3isotype switchingGO:00451909.5MSH2, MLH1

Molecular functions related to Anal Fistula according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:00036979.8MSH2, MLH1
2guanine/thymine mispair bindingGO:00321379.7MSH2, MLH1
3protein bindingGO:00055156.6MLH1, MMP9, MSH2, ALB, S100A7, KRT7

Products for genes affiliated with Anal Fistula

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  • Antibodies
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  • Antibodies
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  • Kits and Assays

Sources for Anal Fistula

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet