MCID: ANL022
MIFTS: 34

Anal Fistula malady

Gastrointestinal diseases, Fetal diseases categories

Summaries for Anal Fistula

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63Wikipedia, 32MalaCards
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Wikipedia:63 Anal fistula, or fistula-in-ano, is an abnormal connection between the epithelialised surface of the... more...

MalaCards: Anal Fistula, also known as anorectal fistula, is related to adenocarcinoma and crohn's disease. An important gene associated with Anal Fistula is MLH1 (mutL homolog 1), and among its related pathways are Colorectal Cancer Metastasis and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds estrogen and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Anal Fistula

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
anal fistula:
Prevalence: 1-5/10000


Aliases & Descriptions:

anal fistula 48
anorectal fistula 60


External Ids:

ICD10 via Orphanet26 K60.3
UMLS via Orphanet61 C0205929
ICD1025 K60.3, K60.5

Related Diseases for Anal Fistula

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17GeneCards, 18GeneDecks
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Diseases related to Anal Fistula via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7EGF, MLH1, MMP9, KRT7, KRT20, MSH2
2crohn's disease30.6ALB
3colon adenocarcinoma30.2EGF, MLH1, KRT20
4skin disease30.0ALB, MMP9
5squamous cell carcinoma30.0S100A7, EGF, MLH1, MMP9, KRT7, KRT20
6peri-anal fistula10.4
7mucinous adenocarcinoma10.3
8tuberculosis10.3
9histiocytosis10.2
10actinomycosis10.1
11imperforate anus10.1
12tuberculous epididymitis10.0
13pulmonary tuberculosis10.0
14proctitis10.0
15teratocarcinoma10.0
16hidradenitis suppurativa10.0
17rectal prolapse10.0
18septic arthritis10.0
19anal squamous cell carcinoma10.0
20anus disease10.0
21arthritis10.0
22hemorrhoid10.0
23hidradenitis10.0
24inflammatory bowel disease10.0
25langerhans-cell histiocytosis10.0
26obesity10.0
27rectal disease10.0
28ductal carcinoma in situ10.0S100A7
29synovial sarcoma10.0KRT7
30inverted papilloma10.0KRT20
31chordoma10.0KRT7
32mixed cell type cancer10.0KRT7
33dermatitis10.0S100A7
34sebaceous adenoma10.0MSH2
35oral cancer10.0MMP9
36papilloma10.0KRT20
37li-fraumeni syndrome10.0MLH1
38cholesteatoma10.0MMP9
39hepatoblastoma10.0KRT7
40thyroid cancer10.0EGF
41meningioma10.0EGF
42leiomyoma10.0EGF
43gastric ulcer10.0EGF
44cholangiocarcinoma10.0KRT20, KRT7
45malignant mesothelioma10.0KRT20, KRT7
46bladder adenocarcinoma10.0KRT7, KRT20
47cervical adenocarcinoma10.0KRT7, KRT20
48mammary paget's disease10.0KRT7, KRT20
49ovarian brenner tumor10.0KRT7, KRT20
50signet ring cell adenocarcinoma10.0KRT7, KRT20

Graphical network of the top 20 diseases related to Anal Fistula:



Diseases related to anal fistula

Clinical Features for Anal Fistula

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Drugs & Therapeutics for Anal Fistula

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Anal Fistula

Drug clinical trials:

Search ClinicalTrials for Anal Fistula

Search NIH Clinical Center for Anal Fistula

Search CenterWatch for Anal Fistula

Genetic Tests for Anal Fistula

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Anatomical Context for Anal Fistula

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32MalaCards
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MalaCards organs/tissues related to Anal Fistula:

32
Skin

Animal Models for Anal Fistula or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Anal Fistula:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0ALB, MSH2, MMP9, MLH1
2MP:00053818.3ALB, MSH2, MMP9, MLH1, EGF

Publications for Anal Fistula

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Genetic Variations for Anal Fistula

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Expression for genes affiliated with Anal Fistula

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anal Fistula

Search GEO for disease gene expression data for Anal Fistula.

Pathways for genes affiliated with Anal Fistula

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Sources:
51QIAGEN, 12EMD Millipore, 49PharmGKB, 29KEGG
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Pathways related to Anal Fistula according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1EGF
2
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.8MSH2, MLH1
39.8MSH2, MLH1
4
Hide members
9.4EGF, MLH1, MSH2
59.0MSH2, MMP9, MLH1, EGF

Compounds for genes affiliated with Anal Fistula

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Anal Fistula according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4S100A7
2vitamin a44 11 2412.2MLH1, MMP9
3n-methyl-n-nitrosourea4410.2MLH1, MSH2
4mononucleotide4410.1MLH1, MSH2
56 thioguanine4410.1MSH2, MLH1
6mnng4410.1MSH2, MLH1
7trapidil4410.1MMP9, EGF
8ilomastat4410.1MMP9, EGF
9temozolomide44 1111.0MLH1, MSH2
10gelfoam4410.0MMP9, ALB
11fosinopril44 1111.0MMP9, ALB
12o6-methylguanine4410.0MLH1, MSH2
13sucralfate44 1111.0EGF, ALB
14irbesartan44 28 49 1112.9ALB, MMP9
15crcs449.8MSH2, MLH1
16sulindac44 1110.7ALB, MLH1
17irinotecan44 49 1111.7EGF, ALB, MLH1
18gefitinib44 49 1111.6MMP9, EGF, ALB
19folate449.6MLH1, MMP9, ALB
205fluorouracil449.6MSH2, EGF, MLH1
21mucicarmine449.4KRT7, KRT20
22methotrexate44 49 1111.3MMP9, KRT7, ALB
23matrigel449.2KRT7, EGF, MMP9
24hyaluronic acid44 2410.2MMP9, KRT20, ALB
25b 723449.1KRT20, KRT7
26streptavidin449.1KRT7, KRT20
27iron44 2410.1KRT7, KRT20, MLH1
28hematoxylin449.1KRT7, KRT20, MMP9
29formaldehyde44 2410.0MMP9, KRT20, KRT7
30doxorubicin44 49 1111.0EGF, MSH2, KRT20, MLH1
31alanine448.9ALB, MSH2, MMP9, MLH1
32retinoic acid44 249.6EGF, S100A7, KRT7, MMP9, MLH1
33progesterone44 59 28 11 2412.6EGF, KRT20, MLH1, KRT7
34paraffin448.4MMP9, MLH1, KRT7, KRT20, MSH2
35vegf448.3MLH1, MMP9, KRT7, KRT20, EGF
36testosterone44 59 11 2411.2EGF, MMP9, KRT7, KRT20, ALB
37tyrosine447.6KRT20, KRT7, MMP9, MLH1, EGF

GO Terms for genes affiliated with Anal Fistula

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16Gene Ontology
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Biological processes related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:0062989.8MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:0164469.7MSH2, MLH1
3isotype switchingGO:0451909.5MSH2, MLH1

Molecular functions related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:0321379.5MLH1, MSH2
2protein bindingGO:0055156.6S100A7, EGF, MLH1, MMP9, KRT7, KRT20

Products for genes affiliated with Anal Fistula

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Anal Fistula

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet