MCID: ANL022
MIFTS: 45

Anal Fistula malady

Gastrointestinal diseases, Fetal diseases, Rare diseases categories
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Summaries for Anal Fistula

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65Wikipedia, 33MalaCards
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Wikipedia:65 Anal fistula, or fistula-in-ano, is an abnormal connection between the epithelialised surface of the... more...

MalaCards: Anal Fistula, also known as anorectal fistula, is related to adenocarcinoma and crohn's disease. An important gene associated with Anal Fistula is MLH1 (mutL homolog 1), and among its related pathways are DNA damage Role of Brca1 and Brca2 in DNA repair and Telomere C-strand (Lagging Strand) Synthesis. The compounds n-methyl-n-nitrosourea and mononucleotide have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and small intestine, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Anal Fistula

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Sources:
49Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

49
anal fistula:
Prevalence: 1-5/10000


Aliases & Descriptions:

anal fistula 49
anorectal fistula 62


External Ids:

ICD10 via Orphanet26 K60.3
UMLS via Orphanet63 C0205929
ICD1025 K60.3, K60.5

Related Diseases for Anal Fistula

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17GeneCards, 18GeneDecks
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Diseases related to Anal Fistula via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.6MLH1, MMP9, MSH2, KRT7, KRT20, EGF
2crohn's disease10.5
3peri-anal fistula10.4
4sepsis10.4
5mucinous adenocarcinoma10.4
6tuberculosis10.3
7histiocytosis10.2
8turcot syndrome10.1MLH1
9intestinal obstruction10.1ALB
10sebaceous adenoma10.1MSH2
11bladder adenocarcinoma10.1KRT7, KRT20
12mammary paget's disease10.1KRT7, KRT20
13ovarian brenner tumor10.1KRT20, KRT7
14signet ring cell adenocarcinoma10.1KRT20, KRT7
15mucinous cystadenocarcinoma10.1KRT7, KRT20
16cutaneous paget's disease10.1KRT20, KRT7
17pancreatic ductal carcinoma10.1KRT20, KRT7
18pseudomyxoma peritonei10.1KRT20, KRT7
19bronchiolo-alveolar adenocarcinoma10.1KRT7, KRT20
20cervical adenocarcinoma10.1KRT7, KRT20
21tubular adenocarcinoma10.1KRT20, KRT7
22meningioma10.1EGF
23abrikosov's tumor10.1KRT7, KRT20
24adenosquamous carcinoma10.1KRT7, KRT20
25large cell carcinoma10.1KRT7, KRT20
26adenoid cystic carcinoma10.1KRT7, KRT20
27neuroendocrine carcinoma10.1KRT7, KRT20
28oxyphilic adenoma10.1KRT7, KRT20
29langerhans-cell histiocytosis10.1
30pulmonary tuberculosis10.1
31tuberculous epididymitis10.1
32hidradenitis suppurativa10.1
33rectal prolapse10.1
34septic arthritis10.1
35proctitis10.1
36teratocarcinoma10.1
37arthritis10.1
38hemorrhoid10.1
39hidradenitis10.1
40inflammatory bowel disease10.1
41obesity10.1
42blindness10.1
43epididymitis10.1
44gallbladder cancer10.1KRT7, MLH1
45barrett's esophagus10.1KRT20, KRT7
46muir-torre syndrome10.1MLH1, MSH2
47keratoacanthoma10.1MLH1, MSH2
48familial colorectal cancer10.0MSH2, MLH1
49malignant mesothelioma10.0KRT7, KRT20
50lynch syndrome10.0MLH1, MSH2

Graphical network of the top 20 diseases related to Anal Fistula:



Diseases related to anal fistula

Symptoms for Anal Fistula

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Drugs & Therapeutics for Anal Fistula

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Anal Fistula

Search NIH Clinical Center for Anal Fistula

Genetic Tests for Anal Fistula

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Anatomical Context for Anal Fistula

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33MalaCards
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MalaCards organs/tissues related to Anal Fistula:

33
Skin, Colon, Small intestine

Animal Models for Anal Fistula or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Anal Fistula:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0ALB, MSH2, MMP9, MLH1
2MP:00053818.3EGF, ALB, MSH2, MMP9, MLH1

Publications for Anal Fistula

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Sources:
52PubMed
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Articles related to Anal Fistula:

(show top 50)    (show all 234)
idTitleAuthorsYear
1
Overview of anal fistula and systematic review of ligation of the intersphincteric fistula tract (LIFT). (23893217)
2014
2
Long-term outcome of the anal fistula plug for anal fistula of cryptoglandular origin. (23981140)
2013
3
The OTSCAr Proctology clip system for anal fistula closure: first prospective clinical data. (23971828)
2013
4
Is the placement of the new synthetic anal fistula plug really so ineffective? (22513443)
2012
5
Collagen matrix injection combined with flap repair for complex anal fistula. (23136821)
2012
6
Why do we have so much trouble treating anal fistula? (21876616)
2011
7
The efficacy of anal fistula plug in fistula-in-ano: a systematic review. (19438881)
2010
8
Outcomes of anal fistula surgery in patients with inflammatory bowel disease. (20466103)
2010
9
Successful treatment of an enterocutaneous fistula with an anal fistula plug after an abdominal stab wound. (20171563)
2010
10
Anal fistula with a tuberculous origin. (20221764)
2010
11
Incision and drainage of perianal abscess with or without treatment of anal fistula. (20614450)
2010
12
To plug or not to plug: a cost-effectiveness analysis for complex anal fistula. (19733880)
2010
13
Randomized clinical trial of anal fistula plug versus endorectal advancement flap for the treatment of high cryptoglandular fistula in ano (Br J Surg 2009; 96: 608-612). (19591140)
2009
14
Core out fistulectomy, anal sphincter reconstruction and primary repair of internal opening in the treatment of complex anal fistula. (19459524)
2009
15
A case of langerhans cell histiocytosis with anal fistula. (20505285)
2009
16
Surgical treatment of complex anal fistulas with the anal fistula plug: a prospective, multicenter study. (19690485)
2009
17
Anal fistula: an unusual presentation of tuberculosis in a migrant health care professional. (18830735)
2009
18
Efficacy of the anal fistula plug in complex anorectal fistulae. (18637922)
2009
19
Anal fistula plug in high fistula-in-ano: an early Saudi experience. (19690486)
2009
20
To determine the efficacy of anal fistula plug in the treatment of high fistula-in-ano: an initial experience. (18637937)
2009
21
Haemorrhoids, rectal prolapse, anal fissure, peri-anal fistulae and sexually transmitted diseases. (19647691)
2009
22
Adenocarcinoma of the rectosigmoid colon seeding into pre-existing anal fistula. (18705305)
2008
23
Early experience with the bioabsorbable anal fistula plug. (18373120)
2008
24
The Surgisis AFP anal fistula plug: a new and reasonable alternative for the treatment of anal fistula. (18947949)
2008
25
Microbiological analysis and endoanal ultrasonography for diagnosis of anal fistula in acute anorectal sepsis. (16601946)
2007
26
Evaluation of the use of BioGlue in the treatment of high anal fistulas: preliminary results of a pilot study. (17164962)
2007
27
Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. (17082891)
2006
28
Randomized clinical trial of local gentamicin-collagen treatment in advancement flap repair for anal fistula. (16952209)
2006
29
Efficacy of anal fistula plug in closure of Crohn's anorectal fistulas. (16998638)
2006
30
Mucinous adenocarcinoma associated with chronic anal fistula reconstructed by gracilis myocutaneous flaps. (16969607)
2006
31
Cancer in the anal canal, and in an anal fistula, that developed during a longstanding course of Crohn's disease. (16261439)
2005
32
Internal anal sphincter preservation with seton rerouting in high transsphincteric anal fistula. (15937616)
2005
33
Radiofrequency fistulotomy: a better alternative for treating low anal fistula. (15543373)
2004
34
Radio frequency fistulotomy--novel modification of the conventional technique in low anal fistula. (15225449)
2004
35
Radio frequency fistulotomy--a novel modification of the conventional technique in low anal fistula. (15346801)
2004
36
Complex anal fistula surgery: personal experience. (15452991)
2004
37
Simplified placement and management of cutting setons in the treatment of transsphincteric anal fistula: technical note. (14762677)
2004
38
Anal lesion resulting from implantation of viable tumour cells in a pre-existing anal fistula. A case report. (12136546)
2002
39
Combined seton-double flap procedure for complex high anal fistula. (12077648)
2002
40
A calculus within an anal fistula tract in a diabetic patient. (11299415)
2001
41
Cow's milk-protein allergy as a cause of anal fistula and fissures: a case report. (9449512)
1998
42
Post operative wound healing with kshaarasutra - a new approach in high anal fistula. (22556730)
1995
43
Anal fistula. (1555083)
1992
44
Congenital anal fistula with normal anus. (2724010)
1989
45
Use of hydrogen peroxide to identify internal opening of anal fistula and perianal abscess. (3459454)
1986
46
Anal fistula: a review of 82 cases. (1248349)
1976
47
Colloid carcinoma arising in an anal fistula: case report with a brief review of the literature. (168847)
1975
48
Hidradenitis suppurativa; its confusion with pilonidal disease and anal fistula. (18111693)
1949
49
Experiences in primary closure following excision of anal fistula. (18879182)
1948
50
Is anal fistula a necessary sequel to perianal abscess? (18899254)
1948

Variations for Anal Fistula

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Expression for genes affiliated with Anal Fistula

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anal Fistula

Search GEO for disease gene expression data for Anal Fistula.

Pathways for genes affiliated with Anal Fistula

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Sources:
50PathCards, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG, 51PharmGKB
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Pathways related to Anal Fistula according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MSH2, MLH1
2
Show member pathways
9.8MSH2, MLH1
3
Show member pathways
Catalytic cycle of mammalian FMOs38
9.8MSH2, MLH1
4
Show member pathways
9.8MSH2, MLH1
5
Show member pathways
Signal transduction PTEN pathway60
9.4MLH1, MSH2, EGF
69.0EGF, MSH2, MMP9, MLH1
79.0EGF, MSH2, MMP9, MLH1

Compounds for genes affiliated with Anal Fistula

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Anal Fistula according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1n-methyl-n-nitrosourea4510.2MSH2, MLH1
2mononucleotide4510.2MSH2, MLH1
36 thioguanine4510.2MLH1, MSH2
4mnng4510.1MLH1, MSH2
5temozolomide45 1111.1MSH2, MLH1
6trapidil4510.1EGF, MMP9
7ilomastat4510.1MMP9, EGF
8o6-methylguanine4510.1MSH2, MLH1
9gelfoam4510.0ALB, MMP9
10fosinopril45 1111.0MMP9, ALB
11crcs4510.0MLH1, MSH2
12sucralfate45 1111.0ALB, EGF
13irbesartan45 29 51 1113.0ALB, MMP9
14sulindac45 1110.9ALB, MLH1
15erlotinib45 51 1111.8EGF, ALB
165fluorouracil459.7EGF, MSH2, MLH1
17ivig459.7ALB, MMP9
18irinotecan45 51 1111.7MLH1, ALB, EGF
19folate459.7ALB, MMP9, MLH1
20mucicarmine459.7KRT20, KRT7
21gefitinib45 51 1111.7MMP9, ALB, EGF
22celecoxib45 61 29 51 24 1114.6ALB, MMP9
23b 723459.6KRT20, KRT7
24streptavidin459.6KRT20, KRT7
25proline459.5MSH2, MMP9, MLH1
26hyaluronic acid45 2410.5KRT20, ALB, MMP9
27lactose45 1110.5MMP9, KRT7
28hematoxylin459.4MMP9, KRT7, KRT20
29methotrexate51 45 1111.4KRT7, ALB, MMP9
30matrigel459.4EGF, KRT7, MMP9
31formaldehyde45 2410.3MMP9, KRT7, KRT20
32doxorubicin45 51 1111.3EGF, KRT20, MSH2, MLH1
33alanine459.3MLH1, MMP9, MSH2, ALB
34vitamin a45 24 1111.1KRT7, ALB, MMP9, MLH1
35cisplatin45 51 61 1112.1EGF, MSH2, MLH1
36fatty acid459.1S100A7, ALB, MLH1
37progesterone45 29 61 24 1113.0MLH1, KRT7, KRT20, EGF
38iron45 2410.0KRT20, KRT7, ALB, MLH1
39paraffin458.7KRT20, KRT7, MSH2, MMP9, MLH1
40vegf458.7EGF, KRT20, KRT7, MMP9, MLH1
41retinoic acid45 249.6EGF, KRT7, S100A7, MMP9, MLH1
42calcium45 51 24 1111.5MLH1, MMP9, ALB, S100A7, EGF
43tyrosine458.5MLH1, MMP9, KRT7, KRT20, EGF
44testosterone45 61 24 1111.5MMP9, ALB, KRT7, KRT20, EGF
45estrogen458.1MLH1, MMP9, S100A7, KRT7, KRT20, EGF

GO Terms for genes affiliated with Anal Fistula

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16Gene Ontology
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Cellular components related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6EGF, ALB

Biological processes related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:0062989.8MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:0164469.7MSH2, MLH1
3isotype switchingGO:0451909.5MSH2, MLH1

Molecular functions related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.8MSH2, MLH1
2guanine/thymine mispair bindingGO:0321379.7MSH2, MLH1
3protein bindingGO:0055156.6MLH1, MMP9, MSH2, ALB, S100A7, KRT7

Products for genes affiliated with Anal Fistula

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  • Antibodies
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Sources for Anal Fistula

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet