MCID: ANL022
MIFTS: 43

Anal Fistula malady

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Anal Fistula

Aliases & Descriptions for Anal Fistula:

Name: Anal Fistula 38 12 56 14
Anorectal Fistula 69

Characteristics:

Orphanet epidemiological data:

56
anal fistula
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Disease Ontology 12 DOID:0060328
ICD10 33 K60.3 K60.5
Orphanet 56 ORPHA228113
UMLS via Orphanet 70 C0205929
ICD10 via Orphanet 34 K60.3

Summaries for Anal Fistula

Disease Ontology : 12 An anus disease characterized by is an abnormal connection between the epithelialised surface of the anal canal and the perianal skin.

MalaCards based summary : Anal Fistula, also known as anorectal fistula, is related to proctitis and peri-anal fistula. An important gene associated with Anal Fistula is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and small intestine, and related phenotype is digestive/alimentary.

Wikipedia : 71 Anal fistula (plural fistulae), or fistula-in-ano, is a chronic abnormal communication between the... more...

Related Diseases for Anal Fistula

Diseases related to Anal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 proctitis 29.3 MLH1 MMP9 MSH2
2 peri-anal fistula 12.1
3 crohn's disease 10.2
4 cutaneous fibrous histiocytoma 10.2 DEFB4A EGF
5 stenosis of lacrimal sac 10.2 DEFB4A MMP9
6 toxic megacolon 10.2 MMP9 MSH2
7 adenocarcinoma 10.1
8 marginal zone b-cell lymphoma 10.1 EGF MMP9
9 plague 10.1 EGF MMP9
10 vascular dementia 10.1 DEFB4A MMP9
11 large intestine adenoma 10.1 MLH1 MSH2
12 skin melanoma 10.1 MLH1 MSH2
13 fibrolamellar carcinoma 10.1 MLH1 MSH2
14 familial hypopituitarism 10.1 MLH1 MSH2
15 neuropathy, distal hereditary motor, type viib 10.1 MLH1 MSH2
16 neurocutaneous melanosis, somatic 10.1 MLH1 MSH2
17 churg-strauss syndrome 10.1 MLH1 MSH2
18 cauda equina neoplasm 10.1 MLH1 MSH2
19 neurofibromatosis-noonan syndrome 10.1 MLH1 MSH2
20 mismatch repair cancer syndrome 10.1 MLH1 MSH2
21 collecting duct carcinoma 10.0 MLH1 MSH2
22 neuroretinitis 10.0 MLH1 MSH2
23 fibromatosis, gingival, 1 10.0 MLH1 MSH2
24 lattice corneal dystrophy 10.0 MLH1 MMP9
25 spastic hemiplegia 10.0 DEFB4A EGF MMP9
26 hnrnpa1-related amyotrophic lateral sclerosis 10.0 MLH1 MSH2
27 malignant spindle cell melanoma 10.0 MLH1 MSH2
28 wolffian duct adenoma 10.0 MLH1 MSH2
29 ideomotor apraxia 10.0 MLH1 MSH2
30 skin papilloma 10.0 MLH1 MSH2
31 larynx liposarcoma 10.0 MLH1 MSH2
32 congenital symblepharon 10.0 MLH1 MSH2
33 hypochondriasis 10.0 AHSP KIDINS220
34 rhinosporidiosis 9.9 EGF MLH1 MMP9
35 asperger syndrome 9.9 MLH1 MSH2
36 rectum sarcoma 9.9 MLH1 MSH2
37 mucinous adenocarcinoma 9.9
38 tuberculosis 9.9
39 mucositis 9.9
40 benign fibrous mesothelioma 9.9 EGF MLH1 MSH2
41 oral squamous cell carcinoma 9.9 MLH1 MSH2
42 autosomal genetic disease 9.8 MLH1 MSH2
43 muscular dystrophy-dystroglycanopathy , type b, 2 9.8 EGF MLH1 MSH2
44 obesity 9.8
45 histiocytosis 9.8
46 inflammatory bowel disease 9.8
47 bardet-biedl syndrome 9.8 EGF MLH1 MMP9 MSH2
48 hidradenitis 9.6
49 pulmonary tuberculosis 9.6
50 currarino syndrome 9.6

Graphical network of the top 20 diseases related to Anal Fistula:



Diseases related to Anal Fistula

Symptoms & Phenotypes for Anal Fistula

MGI Mouse Phenotypes related to Anal Fistula:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 EGF MLH1 MMP9 MSH2

Drugs & Therapeutics for Anal Fistula

Drugs for Anal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
4
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Prilocaine Approved Phase 4 721-50-6 4906
7
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Loperamide Approved Phase 4 53179-11-6 3955
10
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
11
Certolizumab pegol Approved Phase 4 428863-50-7
12
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
13
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
14
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
15 Adrenergic Agents Phase 4
16 Adrenergic Agonists Phase 4
17 Adrenergic alpha-2 Receptor Agonists Phase 4
18 Adrenergic alpha-Agonists Phase 4
19 Analgesics Phase 4
20 Analgesics, Non-Narcotic Phase 4
21 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
22 Anesthetics, General Phase 4,Phase 2
23 Anesthetics, Intravenous Phase 4
24 Central Nervous System Depressants Phase 4
25 Hypnotics and Sedatives Phase 4
26 Neurotransmitter Agents Phase 4
27 Peripheral Nervous System Agents Phase 4
28 Anti-Inflammatory Agents Phase 4
29 Antirheumatic Agents Phase 4
30 Epinephryl borate Phase 4,Phase 2
31 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
32 Racepinephrine Phase 4,Phase 2
33 Adjuvants, Anesthesia Phase 4
34 Analgesics, Opioid Phase 4
35 Anesthetics, Local Phase 4
36 Narcotics Phase 4
37 Anti-Arrhythmia Agents Phase 4
38 Anti-Inflammatory Agents, Non-Steroidal Phase 4
39 Cyclooxygenase Inhibitors Phase 4
40 Diuretics, Potassium Sparing Phase 4
41 Sodium Channel Blockers Phase 4
42 Antidiarrheals Phase 4
43 Gastrointestinal Agents Phase 4
44 Anti-Anxiety Agents Phase 4
45 Anticonvulsants Phase 4
46 Antimanic Agents Phase 4
47 Antiparkinson Agents Phase 4
48 calcium channel blockers Phase 4
49 Calcium, Dietary Phase 4
50 Excitatory Amino Acid Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 71)
id Name Status NCT ID Phase
1 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4
2 Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl Completed NCT01880775 Phase 4
3 Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery Completed NCT02961855 Phase 4
4 Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation Completed NCT02147574 Phase 4
5 A Prospective Evaluation of the Strattice-LIFT to Treat Anal Fistula Recruiting NCT02423330 Phase 4
6 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Recruiting NCT02216305 Phase 4
7 Multi-Drug Analgesia vs. Standard Solution for Anal Surgery Not yet recruiting NCT03105674 Phase 4
8 Gabapentin for Postop Pain After SSLF Not yet recruiting NCT03123861 Phase 4
9 Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery Not yet recruiting NCT02848157 Phase 4
10 EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment Terminated NCT01582568 Phase 4
11 Anal Fistula Repair With Platelet-rich Plasma Withdrawn NCT02678936 Phase 4
12 Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug Procedure for Anal Fistula Repair Unknown status NCT01478139 Phase 3
13 Clinical Trial to Evaluate the Efficacy and Safety of Stem Cells Unknown status NCT01803347 Phase 3
14 Treatment of Perirectal Fistula With Cutting Seton vs. Collagen Plug Completed NCT00450671 Phase 3
15 Efficacy and Safety of Adipose Stem Cells to Treat Complex Perianal Fistulas Not Associated to Crohn´s Disease Completed NCT00475410 Phase 3
16 Evaluation of Topical 10% Metronidazole Ointment for the Treatment of Active Perianal Crohn's Disease Completed NCT00509639 Phase 3
17 Therapeutic Management of Complex Anal Fistulas by Installing a Closure Clip: Multicentre Randomized Controlled Trial Recruiting NCT02336867 Phase 2, Phase 3
18 Adipose Derived Mesenchymal Stem Cells for Induction of Remission in Perianal Fistulizing Crohn's Disease Active, not recruiting NCT01541579 Phase 3
19 Feasibility Study to Assess the Early Use of Porcine Cross-linked Collagen Paste in Cryptoglandular Anorectal Fistulas Not yet recruiting NCT02686580 Phase 3
20 The Role of MSC in the Treatment of Fistulas in Patients With Perianal Crohn's Disease Not yet recruiting NCT03056664 Phase 2, Phase 3
21 Seton or Glue for Trans-sphincteric Anal Fistulas Terminated NCT00929630 Phase 3
22 Gore-BioA Fistula Plug to Treat Transsphincteric Fistulas Terminated NCT01584752 Phase 3
23 A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas Unknown status NCT02456324 Phase 2
24 Autologous Stem Cells Derived From Lipoaspirates for the Non-Surgical Treatment of Complex Perianal Fistula Unknown status NCT00115466 Phase 2
25 Success Rate, Continence, and Quality of Life With a Bioprosthetic Plug for Treating Complex Anal Fistula Completed NCT01612195 Phase 2
26 Study to Assess the Safety and Efficacy of Expanded Allogenic Adipose-derived Stem Cells (eASCs) (Cx601), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease. Completed NCT01372969 Phase 1, Phase 2
27 Efficacy and Safety Study of a Medical Device (KULIST)to Treat Perianal Fistulas Completed NCT01462747 Phase 2
28 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2
29 An Innovative Treatment for Fistula-in-ano in Crohn Disease : Local Micro Reinjection of Autologous Fat and SVF Recruiting NCT02520843 Phase 1, Phase 2
30 Autologous Adipose-derived Stem Cells (ASCs) for the Treatment of Perianal Fistula in Crohn Disease: A Pilot Study Recruiting NCT02403232 Phase 2
31 Efficacy of Delayed Coloanal Anastomosis for Medium and Lower Rectum Cancer Treatment. Phase 2 Clinical Trial (CASCADOR) Recruiting NCT01876901 Phase 2
32 Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy Completed NCT02308631 Phase 1
33 Anal Fistula Plug Versus Endorectal Advancement Flap Unknown status NCT01931371
34 Ligation of Intersphincteric Fistula Tract (LIFT) Procedure Versus Use of an Anal Fistula Plug for Anal Fistula Repair Unknown status NCT00830661
35 Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula Unknown status NCT01929525
36 The Efficacy of Human Acellular Dermal Matrix in the Treatment of Anal Fistula Unknown status NCT00951002
37 Is the Use of Blood Platelets Effective in the Treatment of Difficult Fistulas Related to the Anal Sphincter? Unknown status NCT01615302
38 Surgical Treatment of High Perianal Fistulas Unknown status NCT01997645
39 Anal Crohn Fistula Surgery Unknown status NCT01388257
40 Packing of Perianal Abscess Cavities Trial: A Randomised Multicentre Trial Comparing Packing With Non-packing of the Abscess Cavity Unknown status NCT01739478
41 A Multi Center Clinical Trial of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421
42 Surgisis Anal Fistula Plug Study: An Experience in Saudi Arabia Completed NCT00703131
43 A Randomized Clinical Trial Comparing Surgisis AFP to Advancement Flap for the Repair of Anal Fistulas Completed NCT00545441
44 Ligation of the Intersphincteric Fistula Tract (LIFT) + Biodesign for Anal Fistula Completed NCT01602081
45 Treatment of Anal Fistulas Advancement Flap Completed NCT01042821
46 Anal Fistula Treatment Outcome - Collagen Plug Versus Advancement Flap Surgery Completed NCT01021774
47 Management of Fistula in Ano by Kshar Sutra, Para Surgical Procedure. Completed NCT01880398
48 Role of Udumbara Sutra in the Management of Fistula in Ano a Rare Case Study Completed NCT01954225
49 Do Antibiotics Prevent Anal Fistulae Formation? Completed NCT01012843
50 A Prospective, Multi-center, Observational Study of the Use of Permacol™ Collagen Paste to Treat Anorectal Fistulas Completed NCT01624350

Search NIH Clinical Center for Anal Fistula

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Anal Fistula cell therapies at LifeMap Discovery.

Genetic Tests for Anal Fistula

Anatomical Context for Anal Fistula

MalaCards organs/tissues related to Anal Fistula:

39
Skin, Colon, Small Intestine

Publications for Anal Fistula

Articles related to Anal Fistula:

(show top 50) (show all 319)
id Title Authors Year
1
Clinical efficacy of adalimumab versus infliximab and the factors associated with recurrence or aggravation during treatment of anal fistulas in Crohn's disease. ( 28522947 )
2017
2
Direct and indirect costs for anal fistula in Sweden. ( 27671704 )
2016
3
Treating anal fistula with the anal fistula plug: case series report of 12 patients. ( 27280009 )
2016
4
Preliminary results of video-assisted anal fistula treatment (VAAFT) in children. ( 26956836 )
2016
5
Similar outcomes for anti-tumor necrosis factor-I+ antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula. ( 27588113 )
2016
6
A systematic review of the management of anal fistula in infants. ( 27663698 )
2016
7
Comparison of Endoanal Ultrasound with Clinical Diagnosis in Anal Fistula Assessment. ( 27266219 )
2016
8
Management of low transsphincteric anal fistula with serial setons and interval muscle-cutting fistulotomy. ( 26988437 )
2016
9
Immunopathological characterisation of crypto glandular anal fistula: A pilot study investigating the pathogenesis. ( 27649390 )
2016
10
An experience with video-assisted anal fistula treatment (VAAFT) with new insights into the treatment of anal fistulae. ( 27059492 )
2016
11
Pharmacological evaluation for improvement of Kanazawa Sutra, medicinal thread for anal fistula. ( 27900596 )
2016
12
Use of a Balloon Rectal Catheter in Magnetic Resonance Imaging of Complex Anal Fistula to Improve Detection of Internal Openings. ( 26953770 )
2016
13
The Sun King's anal fistula. ( 27554569 )
2016
14
Comparison of histopathology, acid fast bacillus smear and real-time polymerase chain reaction for detection of Mycobacterium tuberculosis in anal fistula in 161 patients: A prospective controlled trial. ( 28043558 )
2016
15
Quality of life with anal fistula. ( 27087327 )
2016
16
Results of the Gore Bio-A fistula plug implantation in the treatment of anal fistula: a multicentre study. ( 27418257 )
2016
17
Response to Re: Long-term results of the cutting seton for high anal fistula. ( 26940185 )
2016
18
Comparison of an anal fistula plug and mucosa advancement flap for complex anal fistulas: a meta-analysis. ( 27680894 )
2016
19
The anal fistula plug in Crohn's disease patients with fistula-in-ano: a systematic review. ( 26749385 )
2016
20
Case of anal fistula with Fournier's gangrene in an obese typeA 2 diabetes mellitus patient. ( 27042282 )
2016
21
Re: Long-term results of the cutting seton for high anal fistula. ( 26940184 )
2016
22
The type of loose seton for complex anal fistula is essential to improve perianal comfort and quality of life. ( 26999764 )
2016
23
Meta-analysis of randomized clinical trials comparing fistulectomy versus fistulotomy for low anal fistula. ( 27777858 )
2016
24
Video Assisted Anal Fistula Treatment in a Child with Perianal Fistula. ( 26816676 )
2016
25
High Ligation of the Anal Fistula Tract by Lateral Approach. ( 26071012 )
2015
26
VAAFT: Video Assisted Anal Fistula Treatment; Bringing revolution in Fistula treatment. ( 26649020 )
2015
27
Anal fistula closure with FiLaC: new hope or the same old story? ( 26187539 )
2015
28
Long-term outcome after surgery for Crohn's anal fistula. ( 26338142 )
2015
29
Comment on: Easy clip to treat anal fistula tracts: a word of caution by M. Gautier et al. ( 25893473 )
2015
30
Psychological stress in patients with anal fistula. ( 25976930 )
2015
31
Modern management of anal fistula. ( 25574077 )
2015
32
Impact of three-dimensional endoanal ultrasound on the outcome of anal fistula surgery: a prospective cohort study. ( 26331275 )
2015
33
Commentary on 'Impact of 3-dimensional endoanal ultrasound on the outcome of anal fistula surgery: a prospective cohort study'. ( 26547818 )
2015
34
Inflammation in anal fistula. ( 25951235 )
2015
35
Minimally Invasive Anal Fistula Treatment-a True Minimal Invasive Surgical Procedure. ( 26884652 )
2015
36
Evaluation and management of perianal abscess and anal fistula: a consensus statement developed by the Italian Society of Colorectal Surgery (SICCR). ( 26377581 )
2015
37
The results of seton drainage combined with anti-TNFI+ therapy for anal fistula in Crohn's disease. ( 25425534 )
2015
38
PERFACT procedure: A new concept to treat highly complex anal fistula. ( 25852290 )
2015
39
Anal Fistula Plug for Perianal Fistulising Crohn's Disease: an Important Trial for Inflammatory Bowel Disease Surgeons. ( 26363516 )
2015
40
Novel application of anal fistula plug for the treatment of chronic anastomotic sinus. ( 25735926 )
2015
41
A case of metastatic carcinoma of anal fistula caused by implantation from rectal cancer. ( 26943447 )
2015
42
Current management of anal fistulas in Crohn's disease. ( 26557938 )
2015
43
The ligation of the intersphincteric fistula tract procedure for anal fistula: a mixed bag of results. ( 25944433 )
2015
44
Fistulotomy or fistulectomy and primary sphincteroplasty for anal fistula (FIPS): a systematic review. ( 26062740 )
2015
45
Ligation of Intersphincteric Fistula Tract vs Ligation of the Intersphincteric Fistula Tract Plus a Bioprosthetic Anal Fistula Plug Procedure in Patients With Transsphincteric Anal Fistula: Early Results of a Multicenter Prospective Randomized Trial. ( 26606429 )
2015
46
Treatment of non-IBD anal fistula. ( 26050835 )
2015
47
Long head of biceps femoris flap in anal fistula treatment: anatomical study and case report. ( 26021955 )
2015
48
Prospective multicenter study of a synthetic bioabsorbable anal fistula plug to treat cryptoglandular transsphincteric anal fistulas. ( 25664714 )
2015
49
Long-term results of the cutting seton for high anal fistula. ( 25997475 )
2015
50
"Core out" or "curettage" in rectal advancement flap for cryptoglandular anal fistula. ( 25612521 )
2015

Variations for Anal Fistula

Expression for Anal Fistula

Search GEO for disease gene expression data for Anal Fistula.

Pathways for Anal Fistula

GO Terms for Anal Fistula

Biological processes related to Anal Fistula according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 activation of MAPKK activity GO:0000186 9.48 EGF KIDINS220
2 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.46 MLH1 MSH2
3 mismatch repair GO:0006298 9.43 MLH1 MSH2
4 positive regulation of DNA binding GO:0043388 9.4 EGF MMP9
5 isotype switching GO:0045190 9.37 MLH1 MSH2
6 somatic hypermutation of immunoglobulin genes GO:0016446 9.32 MLH1 MSH2
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.26 MLH1 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MLH1 MSH2
9 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MLH1 MSH2
10 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Anal Fistula according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Anal Fistula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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