MCID: ANL022
MIFTS: 43

Anal Fistula malady

Gastrointestinal diseases, Rare diseases categories

Summaries for Anal Fistula

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Wikipedia:65 Anal fistula, or fistula-in-ano, is a chronic abnormal communication between the epithelialised surface... more...

MalaCards based summary: Anal Fistula is related to adenocarcinoma and crohn's disease. An important gene associated with Anal Fistula is MLH1 (mutL homolog 1), and among its related pathways are Busulfan Pathway, Pharmacodynamics and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds n-methyl-n-nitrosourea and mononucleotide have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and small intestine, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Anal Fistula

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Sources:
32LifeMap Discovery®, 49Orphanet, 62UMLS, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Anal Fistula, Aliases & Descriptions:

Name: Anal Fistula 32 49 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

49
anal fistula:
Prevalence: 1-5/10000 (Europe)


External Ids:

Orphanet49 228113
ICD10 via Orphanet28 K60.3
UMLS via Orphanet63 C0205929
ICD1027 K60.3

Related Diseases for Anal Fistula

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Diseases related to Anal Fistula via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7MLH1, MMP9, MSH2, KRT7, KRT20, EGF
2crohn's disease10.5
3peri-anal fistula10.5
4mucinous adenocarcinoma10.4
5tuberculosis10.3
6currarino syndrome10.2
7histiocytosis10.2
8obesity10.1
9arthritis10.1
10langerhans-cell histiocytosis10.1
11pulmonary tuberculosis10.1
12tuberculous epididymitis10.1
13hidradenitis suppurativa10.1
14rectal prolapse10.1
15septic arthritis10.1
16proctitis10.1
17teratocarcinoma10.1
18hemorrhoid10.1
19hidradenitis10.1
20inflammatory bowel disease10.1
21blindness10.1
22epididymitis10.1
23intestinal obstruction10.1ALB
24sebaceous adenoma10.1MSH2
25bladder adenocarcinoma10.0KRT7, KRT20
26mammary paget's disease10.0KRT7, KRT20
27ovarian brenner tumor10.0KRT20, KRT7
28signet ring cell adenocarcinoma10.0KRT20, KRT7
29mucinous cystadenocarcinoma10.0KRT7, KRT20
30paget disease, extramammary10.0KRT20, KRT7
31pancreatic ductal carcinoma10.0KRT20, KRT7
32pseudomyxoma peritonei10.0KRT20, KRT7
33bronchiolo-alveolar adenocarcinoma10.0KRT7, KRT20
34cervical adenocarcinoma10.0KRT7, KRT20
35meningioma, familial10.0EGF
36tubular adenocarcinoma10.0KRT20, KRT7
37abrikosov's tumor10.0KRT7, KRT20
38adenosquamous carcinoma10.0KRT7, KRT20
39large cell carcinoma10.0KRT7, KRT20
40salivary gland adenoid cystic carcinoma10.0KRT7, KRT20
41neuroendocrine tumor10.0KRT7, KRT20
42oxyphilic adenoma10.0KRT7, KRT20
43gallbladder cancer10.0KRT7, MLH1
44barrett esophagus/esophageal adenocarcinoma10.0KRT20, KRT7
45muir-torre syndrome10.0MLH1, MSH2
46keratoacanthoma10.0MLH1, MSH2
47familial colorectal cancer10.0MSH2, MLH1
48mismatch repair cancer syndrome10.0MLH1, MSH2
49mesothelioma, somatic10.0KRT7, KRT20
50lynch syndrome10.0MLH1, MSH2

Graphical network of the top 20 diseases related to Anal Fistula:



Diseases related to anal fistula

Symptoms for Anal Fistula

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Drugs & Therapeutics for Anal Fistula

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Drug clinical trials:

Search ClinicalTrials for Anal Fistula

Search NIH Clinical Center for Anal Fistula

Genetic Tests for Anal Fistula

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Anatomical Context for Anal Fistula

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MalaCards organs/tissues related to Anal Fistula:

33
Skin, Colon, Small intestine

Animal Models for Anal Fistula or affiliated genes

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MGI Mouse Phenotypes related to Anal Fistula:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0ALB, MSH2, MMP9, MLH1
2MP:00053818.3EGF, ALB, MSH2, MMP9, MLH1

Publications for Anal Fistula

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Articles related to Anal Fistula:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Overview of anal fistula and systematic review of ligation of the intersphincteric fistula tract (LIFT). (23893217)
2014
2
Video-assisted anal fistula treatment. (25419106)
2014
3
The role of loose seton in the management of anal fistula: a multicenter study of 200 patients. (24989839)
2014
4
Effectiveness of the ligation of intersphincteric fistula tract (LIFT) in the treatment of anal fistula: initial results. (25004286)
2014
5
Long-term outcome of the anal fistula plug for anal fistula of cryptoglandular origin. (23981140)
2013
6
The OTSCAr Proctology clip system for anal fistula closure: first prospective clinical data. (23971828)
2013
7
Is the placement of the new synthetic anal fistula plug really so ineffective? (22513443)
2012
8
Collagen matrix injection combined with flap repair for complex anal fistula. (23136821)
2012
9
Why do we have so much trouble treating anal fistula? (21876616)
2011
10
The efficacy of anal fistula plug in fistula-in-ano: a systematic review. (19438881)
2010
11
Outcomes of anal fistula surgery in patients with inflammatory bowel disease. (20466103)
2010
12
Successful treatment of an enterocutaneous fistula with an anal fistula plug after an abdominal stab wound. (20171563)
2010
13
Anal fistula with a tuberculous origin. (20221764)
2010
14
Randomized clinical trial of anal fistula plug versus endorectal advancement flap for the treatment of high cryptoglandular fistula in ano (Br J Surg 2009; 96: 608-612). (19591140)
2009
15
Core out fistulectomy, anal sphincter reconstruction and primary repair of internal opening in the treatment of complex anal fistula. (19459524)
2009
16
A case of langerhans cell histiocytosis with anal fistula. (20505285)
2009
17
Surgical treatment of complex anal fistulas with the anal fistula plug: a prospective, multicenter study. (19690485)
2009
18
Anal fistula: an unusual presentation of tuberculosis in a migrant health care professional. (18830735)
2009
19
Efficacy of the anal fistula plug in complex anorectal fistulae. (18637922)
2009
20
Anal fistula plug in high fistula-in-ano: an early Saudi experience. (19690486)
2009
21
To determine the efficacy of anal fistula plug in the treatment of high fistula-in-ano: an initial experience. (18637937)
2009
22
Haemorrhoids, rectal prolapse, anal fissure, peri-anal fistulae and sexually transmitted diseases. (19647691)
2009
23
Adenocarcinoma of the rectosigmoid colon seeding into pre-existing anal fistula. (18705305)
2008
24
Early experience with the bioabsorbable anal fistula plug. (18373120)
2008
25
Microbiological analysis and endoanal ultrasonography for diagnosis of anal fistula in acute anorectal sepsis. (16601946)
2007
26
Evaluation of the use of BioGlue in the treatment of high anal fistulas: preliminary results of a pilot study. (17164962)
2007
27
Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. (17082891)
2006
28
Randomized clinical trial of local gentamicin-collagen treatment in advancement flap repair for anal fistula. (16952209)
2006
29
Efficacy of anal fistula plug in closure of Crohn's anorectal fistulas. (16998638)
2006
30
Mucinous adenocarcinoma associated with chronic anal fistula reconstructed by gracilis myocutaneous flaps. (16969607)
2006
31
Cancer in the anal canal, and in an anal fistula, that developed during a longstanding course of Crohn's disease. (16261439)
2005
32
Internal anal sphincter preservation with seton rerouting in high transsphincteric anal fistula. (15937616)
2005
33
Radiofrequency fistulotomy: a better alternative for treating low anal fistula. (15543373)
2004
34
Radio frequency fistulotomy--novel modification of the conventional technique in low anal fistula. (15225449)
2004
35
Radio frequency fistulotomy--a novel modification of the conventional technique in low anal fistula. (15346801)
2004
36
Complex anal fistula surgery: personal experience. (15452991)
2004
37
Anal lesion resulting from implantation of viable tumour cells in a pre-existing anal fistula. A case report. (12136546)
2002
38
Combined seton-double flap procedure for complex high anal fistula. (12077648)
2002
39
A calculus within an anal fistula tract in a diabetic patient. (11299415)
2001
40
Cow's milk-protein allergy as a cause of anal fistula and fissures: a case report. (9449512)
1998
41
Post operative wound healing with kshaarasutra - a new approach in high anal fistula. (22556730)
1995
42
Anal fistula. (1555083)
1992
43
Congenital anal fistula with normal anus. (2724010)
1989
44
Use of hydrogen peroxide to identify internal opening of anal fistula and perianal abscess. (3459454)
1986
45
Anal fistula: a review of 82 cases. (1248349)
1976
46
Colloid carcinoma arising in an anal fistula: case report with a brief review of the literature. (168847)
1975
47
Carcinoma arising in anal fistula. (6073791)
1967
48
Hidradenitis suppurativa; its confusion with pilonidal disease and anal fistula. (18111693)
1949
49
Experiences in primary closure following excision of anal fistula. (18879182)
1948
50
Is anal fistula a necessary sequel to perianal abscess? (18899254)
1948

Variations for Anal Fistula

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Expression for genes affiliated with Anal Fistula

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Search GEO for disease gene expression data for Anal Fistula.

Pathways for genes affiliated with Anal Fistula

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Pathways related to Anal Fistula according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Catalytic cycle of mammalian FMOs38
9.8MSH2, MLH1
29.8MSH2, MLH1
3
Show member pathways
9.8MLH1, MSH2
4
Show member pathways
9.8MLH1, MSH2
5
Show member pathways
Signal transduction PTEN pathway60
9.4EGF, MSH2, MLH1
69.0EGF, MSH2, MMP9, MLH1
79.0MLH1, MMP9, MSH2, EGF

Compounds for genes affiliated with Anal Fistula

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Compounds related to Anal Fistula according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1n-methyl-n-nitrosourea4510.2MSH2, MLH1
2mononucleotide4510.2MSH2, MLH1
36 thioguanine4510.2MLH1, MSH2
4mnng4510.1MLH1, MSH2
5temozolomide45 1311.1MSH2, MLH1
6trapidil4510.1EGF, MMP9
7ilomastat4510.1MMP9, EGF
8o6-methylguanine4510.1MSH2, MLH1
9gelfoam4510.0ALB, MMP9
10fosinopril45 1311.0MMP9, ALB
11crcs4510.0MLH1, MSH2
12sucralfate45 1311.0ALB, EGF
13irbesartan45 30 51 1313.0ALB, MMP9
14sulindac45 1310.9ALB, MLH1
15erlotinib45 51 1311.8EGF, ALB
165fluorouracil459.7EGF, MSH2, MLH1
17ivig459.7ALB, MMP9
18irinotecan45 51 1311.7MLH1, ALB, EGF
19folate459.7ALB, MMP9, MLH1
20mucicarmine459.7KRT20, KRT7
21gefitinib45 51 1311.7MMP9, ALB, EGF
22celecoxib45 61 30 51 26 1314.6ALB, MMP9
23b 723459.6KRT20, KRT7
24streptavidin459.6KRT20, KRT7
25proline459.5MSH2, MMP9, MLH1
26hyaluronic acid45 2610.5KRT20, ALB, MMP9
27lactose45 1310.5MMP9, KRT7
28hematoxylin459.4MMP9, KRT7, KRT20
29methotrexate51 45 1311.4KRT7, ALB, MMP9
30matrigel459.4EGF, KRT7, MMP9
31formaldehyde45 2610.3MMP9, KRT7, KRT20
32doxorubicin45 51 1311.3EGF, KRT20, MSH2, MLH1
33alanine459.3MLH1, MMP9, MSH2, ALB
34vitamin a45 26 1311.1KRT7, ALB, MMP9, MLH1
35cisplatin45 51 61 1312.1EGF, MSH2, MLH1
36fatty acid459.1S100A7, ALB, MLH1
37progesterone45 30 61 26 1313.0MLH1, KRT7, KRT20, EGF
38iron45 2610.0KRT20, KRT7, ALB, MLH1
39paraffin458.7KRT20, KRT7, MSH2, MMP9, MLH1
40vegf458.7EGF, KRT20, KRT7, MMP9, MLH1
41retinoic acid45 269.6EGF, KRT7, S100A7, MMP9, MLH1
42calcium45 51 26 1311.5MLH1, MMP9, ALB, S100A7, EGF
43tyrosine458.5MLH1, MMP9, KRT7, KRT20, EGF
44testosterone45 61 26 1311.5MMP9, ALB, KRT7, KRT20, EGF
45estrogen458.1MLH1, MMP9, S100A7, KRT7, KRT20, EGF

GO Terms for genes affiliated with Anal Fistula

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Cellular components related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6EGF, ALB

Biological processes related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00062989.8MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:00164469.7MSH2, MLH1
3isotype switchingGO:00451909.5MSH2, MLH1

Molecular functions related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:00036979.8MSH2, MLH1
2guanine/thymine mispair bindingGO:00321379.7MSH2, MLH1
3protein bindingGO:00055156.6MLH1, MMP9, MSH2, ALB, S100A7, KRT7

Products for genes affiliated with Anal Fistula

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Sources for Anal Fistula

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet