MCID: ANL022
MIFTS: 40

Anal Fistula malady

Gastrointestinal, Fetal categories

Summaries for Anal Fistula

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Anal fistula, or fistula-in-ano, is an abnormal connection between the epithelialised surface of the... more...

MalaCards: Anal Fistula, also known as anorectal fistula, is related to adenocarcinoma and crohn's disease. An important gene associated with Anal Fistula is MLH1 (mutL homolog 1), and among its related pathways are Colorectal Cancer Metastasis and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds estrogen and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include skin, smooth muscle and small intestine, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Anal Fistula

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
anal fistula:
Prevalence: 1-5/10000


Aliases & Descriptions:

anal fistula 49
anorectal fistula 61


External Ids:

ICD10 via Orphanet26 K60.3
UMLS via Orphanet62 C0205929
ICD1025 K60.3, K60.5

Related Diseases for Anal Fistula

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anal Fistula via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.8EGF, MLH1, MMP9, KRT7, KRT20, MSH2
2crohn's disease30.4ALB
3squamous cell carcinoma30.0S100A7, EGF, MLH1, MMP9, KRT7, KRT20
4peri-anal fistula10.6
5sepsis10.4
6mucinous adenocarcinoma10.3
7tuberculosis10.3
8actinomycosis10.1
9imperforate anus10.1
10tuberculous epididymitis10.0
11pulmonary tuberculosis10.0
12proctitis10.0
13teratocarcinoma10.0
14hidradenitis suppurativa10.0
15rectal prolapse10.0
16septic arthritis10.0
17anal squamous cell carcinoma10.0
18anus disease10.0
19arthritis10.0
20epididymitis10.0
21ductal carcinoma in situ10.0S100A7
22synovial sarcoma10.0KRT7
23inverted papilloma10.0KRT20
24chordoma10.0KRT7
25mixed cell type cancer10.0KRT7
26dermatitis10.0S100A7
27sebaceous adenoma10.0MSH2
28oral cancer10.0MMP9
29papilloma10.0KRT20
30li-fraumeni syndrome10.0MLH1
31cholesteatoma10.0MMP9
32hepatoblastoma10.0KRT7
33thyroid cancer10.0EGF
34meningioma10.0EGF
35leiomyoma10.0EGF
36gastric ulcer10.0EGF
37cholangiocarcinoma10.0KRT20, KRT7
38malignant mesothelioma10.0KRT20, KRT7
39bladder adenocarcinoma10.0KRT7, KRT20
40cervical adenocarcinoma10.0KRT7, KRT20
41mammary paget's disease10.0KRT7, KRT20
42ovarian brenner tumor10.0KRT7, KRT20
43signet ring cell adenocarcinoma10.0KRT7, KRT20
44mucinous cystadenocarcinoma10.0KRT7, KRT20
45cutaneous paget's disease10.0KRT20, KRT7
46ulcerative colitis10.0ALB
47pancreatic ductal carcinoma10.0KRT7, KRT20
48peritonitis10.0ALB
49intestinal obstruction10.0ALB
50renal oncocytoma10.0KRT7

Graphical network of the top 20 diseases related to Anal Fistula:



Diseases related to anal fistula

Clinical Features for Anal Fistula

Drugs & Therapeutics for Anal Fistula

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Anal Fistula

Drug clinical trials:

Search ClinicalTrials for Anal Fistula

Search NIH Clinical Center for Anal Fistula

Search CenterWatch for Anal Fistula

Genetic Tests for Anal Fistula

Anatomical Context for Anal Fistula

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anal Fistula:

33
Skin, Smooth muscle, Small intestine, Colon, Pancreas, T cells

Animal Models for Anal Fistula or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Anal Fistula:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0ALB, MSH2, MMP9, MLH1
2MP:00053818.3ALB, MSH2, MMP9, MLH1, EGF

Publications for Anal Fistula

Sources:
51PubMed
See all sources

Articles related to Anal Fistula:

(show top 50)    (show all 293)
idTitleAuthorsYear
1
Ligation of the Intersphincteric Fistula Tract (LIFT): A Minimally Invasive Procedure for Complex Anal Fistula: Two-Year Results of a Prospective Multicentric Study. (24201738)
2013
2
Utility of transperineal and anal ultrasonography in the diagnostics of hidradenitis suppurativa and its differentiation from a rectal fistula. (23175339)
2012
3
Long-term results of surgery plus fibrin sealant for anal fistula. (21819522)
2012
4
Gore Bio-AAr Fistula Plug: a new sphincter-sparing procedure for complex anal fistula. (22288601)
2012
5
Thoracoscopy versus thoracotomy for esophageal atresia and tracheoesophageal fistula repair: review of the literature and meta-analysis. (23172569)
2012
6
Why do we have so much trouble treating anal fistula? (21876616)
2011
7
Seton drainage in high anal fistula. (21279366)
2011
8
A decade of selective use of adjustable cutting seton combined with fistulotomy for anal fistula. (22127093)
2011
9
Anal fistula: intraoperative difficulties and unexpected findings. (21876613)
2011
10
Anal fistula with a tuberculous origin. (20221764)
2010
11
Cryptoglandular anal fistula. (20822966)
2010
12
Epigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases. (20686305)
2010
13
Core out fistulectomy, anal sphincter reconstruction and primary repair of internal opening in the treatment of complex anal fistula. (19459524)
2009
14
Anal fistula plug: initial experience and outcomes. (19279419)
2009
15
Comparison of accuracy of physical examination and endoanal ultrasonography for preoperative assessment in patients with acute and chronic anal fistula. (18679573)
2008
16
Squamous cell carcinoma arising from recurrent anal fistula. (17878704)
2007
17
Clinical and manometric results of endorectal advancement flaps for complex anal fistula. (16896993)
2007
18
Efficacy of anal fistula plug in closure of Crohn's anorectal fistulas. (16998638)
2006
19
Usefulness of anal ultrasonography in anal fistula. (17048992)
2006
20
Cancer in the anal canal, and in an anal fistula, that developed during a longstanding course of Crohn's disease. (16261439)
2005
21
Thoracoscopic repair of esophageal atresia and tracheoesophageal fistula: a multi-institutional analysis. (16135928)
2005
22
Endoanal ultrasound-guided surgery for anal fistula. (16032490)
2005
23
Role of somatostatin analogues in the management of enterocutaneous fistulae. (15228830)
2004
24
Long-term outcome following loose-seton technique for external sphincter preservation in complex anal fistula (Br J Surg 2004; 91: 476-480). (15286975)
2004
25
Ultrastructural analysis of glands located in the wall of the congenital fistulae of the lower lip of patients with Van der Woude syndrome. (21394392)
2003
26
Long-term analysis of children with esophageal atresia and tracheoesophageal fistula. (12778380)
2003
27
Infliximab in refractory pouchitis complicated by fistulae following ileo-anal pouch for ulcerative colitis. (12755839)
2003
28
Change in anal continence after surgery for intersphincteral anal fistula: a functional and manometric study. (12548411)
2003
29
Somatostatin analog treatment of a cervical thoracic duct fistula. (12203809)
2002
30
A calculus within an anal fistula tract in a diabetic patient. (11299415)
2001
31
Full thickness transrectal advancement flap for high anal fistula. (23577814)
1999
32
Seton treatment of anal fistula: experience with a new modification. (9696978)
1998
33
Somatostatin analogues and pancreatic fistulas. (8813483)
1996
34
Persistence of idiopathic anal fistula may be related to epithelialization. (7881949)
1995
35
Post-nephrectomy duodeno-cutaneous fistula resolved with parenteral nutrition and octreotide (somatostatin analogue)]. (7818305)
1994
36
Histological and microbiological assessment of the role of microorganisms in chronic anal fistula. (8402073)
1993
37
Anal fistula. (1555083)
1992
38
Oligohydramnios and megacolon in a fetus with vesicorectal fistula and anal-urethral atresia: a case report. (1442962)
1992
39
Use of bacteriology in anorectal sepsis as an indicator of anal fistula: experience in a district general hospital. (2041020)
1991
40
Jeddah experience in the management of high anal fistula. (17590752)
1991
41
Congenital anal fistula with normal anus. (2724010)
1989
42
Mucinous adenocarcinoma developing in chronic anal fistula: report of two cases and review of the literature. (6271516)
1981
43
A new concept of the anatomy of the anal sphincter mechanism and the physiology of defecation. VII. Anal fistula: a simplified classification. (498899)
1979
44
An interesting case of cancer of the sigmoid with concomitant cancer in an anal fistula. (1085913)
1976
45
The unusual anal fistula. (5683627)
1968
46
Carcinoma arising in anal fistula. (6073791)
1967
47
Colloid carcinoma arising in chronic anal fistula. (13364667)
1956
48
Tuberculous anal fistula with subsequent development of pulmonary tuberculosis; report of cases. (18130004)
1949
49
Experiences in primary closure following excision of anal fistula. (18879182)
1948
50
Tuberculosis and anal fistula. (21016270)
1946

Genetic Variations for Anal Fistula

Expression for genes affiliated with Anal Fistula

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anal Fistula

Search GEO for disease gene expression data for Anal Fistula.

Pathways for genes affiliated with Anal Fistula

Sources:
52QIAGEN, 12EMD Millipore, 50PharmGKB, 30KEGG
See all sources

Pathways related to Anal Fistula according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1EGF
2
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.8MSH2, MLH1
39.8MSH2, MLH1
4
Hide members
9.4EGF, MLH1, MSH2
59.0MSH2, MMP9, MLH1, EGF

Compounds for genes affiliated with Anal Fistula

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Anal Fistula according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1estrogen4510.4S100A7
2vitamin a45 11 2412.2MMP9, MLH1
3n-methyl-n-nitrosourea4510.2MSH2, MLH1
4mononucleotide4510.1MLH1, MSH2
56 thioguanine4510.1MSH2, MLH1
6mnng4510.1MSH2, MLH1
7trapidil4510.1EGF, MMP9
8ilomastat4510.1MMP9, EGF
9temozolomide45 1111.0MLH1, MSH2
10gelfoam4510.0ALB, MMP9
11fosinopril45 1111.0ALB, MMP9
12o6-methylguanine4510.0MSH2, MLH1
13sucralfate45 1111.0ALB, EGF
14irbesartan45 29 50 1112.9MMP9, ALB
15crcs459.8MLH1, MSH2
16sulindac45 1110.7ALB, MLH1
17irinotecan45 50 1111.7ALB, MLH1, EGF
18gefitinib45 50 1111.6EGF, MMP9, ALB
19folate459.6ALB, MMP9, MLH1
205fluorouracil459.6MSH2, MLH1, EGF
21mucicarmine459.4KRT7, KRT20
22methotrexate45 50 1111.3ALB, KRT7, MMP9
23matrigel459.2EGF, MMP9, KRT7
24hyaluronic acid45 2410.2MMP9, KRT20, ALB
25b 723459.1KRT20, KRT7
26streptavidin459.1KRT20, KRT7
27iron45 2410.1MLH1, KRT7, KRT20
28hematoxylin459.1KRT20, KRT7, MMP9
29formaldehyde45 2410.0KRT20, KRT7, MMP9
30doxorubicin45 50 1111.0MSH2, KRT20, MLH1, EGF
31alanine458.9ALB, MSH2, MMP9, MLH1
32retinoic acid45 249.6S100A7, EGF, MLH1, MMP9, KRT7
33progesterone45 60 29 11 2412.6EGF, MLH1, KRT7, KRT20
34paraffin458.4MSH2, KRT20, KRT7, MMP9, MLH1
35vegf458.3EGF, MLH1, MMP9, KRT7, KRT20
36testosterone45 60 11 2411.2EGF, MMP9, KRT7, KRT20, ALB
37tyrosine457.6EGF, MLH1, MMP9, KRT7, KRT20

GO Terms for genes affiliated with Anal Fistula

Sources:
16Gene Ontology
See all sources

Biological processes related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:0062989.8MSH2, MLH1
2somatic hypermutation of immunoglobulin genesGO:0164469.7MSH2, MLH1
3isotype switchingGO:0451909.5MSH2, MLH1

Molecular functions related to Anal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:0321379.5MSH2, MLH1
2protein bindingGO:0055156.6EGF, MLH1, MMP9, KRT7, KRT20, MSH2

Products for genes affiliated with Anal Fistula

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anal Fistula

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet