MCID: ANL022
MIFTS: 45

Anal Fistula

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Anal Fistula

MalaCards integrated aliases for Anal Fistula:

Name: Anal Fistula 37 12 55 14
Anorectal Fistula 69

Characteristics:

Orphanet epidemiological data:

55
anal fistula
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Disease Ontology 12 DOID:0060328
ICD10 32 K60.3 K60.5
Orphanet 55 ORPHA228113
UMLS via Orphanet 70 C0205929
ICD10 via Orphanet 33 K60.3
UMLS 69 C0149889

Summaries for Anal Fistula

Disease Ontology : 12 An anus disease characterized by is an abnormal connection between the epithelialised surface of the anal canal and the perianal skin.

MalaCards based summary : Anal Fistula, also known as anorectal fistula, is related to adenocarcinoma and colorectal adenocarcinoma. An important gene associated with Anal Fistula is MLH1 (MutL Homolog 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Bupivacaine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and small intestine.

Wikipedia : 72 Anal fistula (plural fistulae), or fistula-in-ano, is a chronic abnormal communication between the... more...

Related Diseases for Anal Fistula

Diseases related to Anal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 30.2 EGF MLH1 MSH2
2 colorectal adenocarcinoma 29.6 MLH1 MSH2
3 peri-anal fistula 12.2
4 nijmegen breakage syndrome 11.0
5 crohn's disease 10.3
6 appendix carcinoid tumor 10.2 MLH1 MSH2
7 adenosquamous colon carcinoma 10.2 MLH1 MSH2
8 lower lip cancer 10.2 MLH1 MSH2
9 atypical polypoid adenomyoma 10.2 MLH1 MSH2
10 lynch syndrome i 10.2 MLH1 MSH2
11 melanocytic nevus syndrome, congenital 10.2 MLH1 MSH2
12 childhood kidney cell carcinoma 10.2 MLH1 MSH2
13 cecum adenocarcinoma 10.2 MLH1 MSH2
14 sebaceous adenocarcinoma 10.2 MLH1 MSH2
15 familial colorectal cancer 10.2 MLH1 MSH2
16 small intestine cancer 10.2 MLH1 MSH2
17 muir-torre syndrome 10.2 MLH1 MSH2
18 cheilitis 10.2 MMP9 MSH2
19 keratoacanthoma 10.2 MLH1 MSH2
20 intestinal benign neoplasm 10.2 MLH1 MSH2
21 skin benign neoplasm 10.1 MLH1 MSH2
22 hydronephrosis 10.1 EGF MMP9
23 hereditary breast ovarian cancer syndrome 10.1 MLH1 MSH2
24 mismatch repair cancer syndrome 10.1 MLH1 MSH2
25 colorectal adenoma 10.1 MLH1 MSH2
26 folliculitis 10.1 DEFB4A EGF
27 autosomal genetic disease 10.1 MLH1 MSH2
28 mucinous adenocarcinoma 10.0
29 colonic benign neoplasm 10.0 MLH1 MSH2
30 gingivitis 10.0 DEFB4A MMP9
31 rectal neoplasm 10.0 MLH1 MSH2
32 mycobacterium tuberculosis 1 10.0
33 mucositis 10.0
34 breast adenocarcinoma 10.0 EGF MMP9
35 cholesteatoma 10.0 DEFB4A MMP9
36 anus disease 9.9
37 female reproductive organ cancer 9.9 MLH1 MMP9 MSH2
38 gastrointestinal system cancer 9.9 MLH1 MMP9 MSH2
39 neurofibromatosis, type iv, of riccardi 9.9 MLH1 MSH2
40 sebaceous adenoma 9.9 EGF MLH1 MSH2
41 rectal disease 9.9 AHSP KIDINS220
42 cell type cancer 9.9 EGF MMP9
43 body mass index quantitative trait locus 11 9.8
44 body mass index quantitative trait locus 9 9.8
45 body mass index quantitative trait locus 8 9.8
46 body mass index quantitative trait locus 7 9.8
47 body mass index quantitative trait locus 12 9.8
48 body mass index quantitative trait locus 14 9.8
49 body mass index quantitative trait locus 18 9.8
50 inflammatory bowel disease 9.8

Graphical network of the top 20 diseases related to Anal Fistula:



Diseases related to Anal Fistula

Symptoms & Phenotypes for Anal Fistula

Drugs & Therapeutics for Anal Fistula

Drugs for Anal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
3
Prilocaine Approved Phase 4 721-50-6 4906
4
Certolizumab pegol Approved Phase 4 428863-50-7
5 Anesthetics Phase 4,Phase 3,Phase 2
6 Antirheumatic Agents Phase 4
7 Adjuvants, Anesthesia Phase 4
8 Analgesics Phase 4
9 Analgesics, Opioid Phase 4
10 Anesthetics, General Phase 4,Phase 2
11 Anesthetics, Intravenous Phase 4
12 Anesthetics, Local Phase 4
13 Central Nervous System Depressants Phase 4
14 Narcotics Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Immunosuppressive Agents Phase 4
17 Coagulants Phase 3
18 Fibrin Tissue Adhesive Phase 3
19 Hemostatics Phase 3
20 Pharmaceutical Solutions Phase 3
21 silver nitrate Approved, Investigational
22
Epinephrine Approved, Vet_approved 51-43-4 5816
23
Metronidazole Approved 443-48-1 4173
24 Racepinephrine Approved 329-65-7
25
Adalimumab Approved 331731-18-1 16219006
26
Silicon Approved, Investigational 7440-21-3 4082203
27
Amoxicillin Approved, Vet_approved 26787-78-0 33613 2171
28
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
29
Povidone-iodine Approved 25655-41-8
30
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
31
Lidocaine Approved, Vet_approved 137-58-6 3676
32
Phenytoin Approved, Vet_approved 57-41-0 1775
33
Clindamycin Approved, Vet_approved 18323-44-9 29029
34
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
35
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
36 Anti-Infective Agents
37 Anti-Infective Agents, Local
38 Anti-Bacterial Agents
39 Antibiotics, Antitubercular
40 Epinephryl borate
41 Anti-Inflammatory Agents
42 Disinfectants
43 Turmeric extract
44 Amoxicillin-Potassium Clavulanate Combination
45 Antitubercular Agents
46 beta-Lactamase Inhibitors
47 Clavulanic Acid
48 BB 1101
49 Dexamethasone acetate 1177-87-3
50 Anticonvulsants

Interventional clinical trials:

(show top 50) (show all 55)

# Name Status NCT ID Phase Drugs
1 Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
2 A Prospective Evaluation of the Strattice-LIFT to Treat Anal Fistula Recruiting NCT02423330 Phase 4
3 EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment Terminated NCT01582568 Phase 4 Certolizumab
4 Anal Fistula Repair With Platelet-rich Plasma Withdrawn NCT02678936 Phase 4
5 Therapeutic Management of Complex Anal Fistulas by Installing a Closure Clip: Multicentre Randomized Controlled Trial Unknown status NCT02336867 Phase 2, Phase 3
6 Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug Procedure for Anal Fistula Repair Unknown status NCT01478139 Phase 3
7 Feasibility Study to Assess the Early Use of Porcine Cross-linked Collagen Paste in Cryptoglandular Anorectal Fistulas Unknown status NCT02686580 Phase 3
8 Clinical Trial to Evaluate the Efficacy and Safety of Stem Cells Unknown status NCT01803347 Phase 3 ◦Drug: ASCs. + fibrin glue;fibrin glue
9 Treatment of Perirectal Fistula With Cutting Seton vs. Collagen Plug Completed NCT00450671 Phase 3
10 Efficacy and Safety of Adipose Stem Cells to Treat Complex Perianal Fistulas Not Associated to Crohn´s Disease Completed NCT00475410 Phase 3 ASCs (Cx401, company code);Fibrin adhesive
11 Adipose Derived Mesenchymal Stem Cells for Induction of Remission in Perianal Fistulizing Crohn's Disease Active, not recruiting NCT01541579 Phase 3
12 Seton or Glue for Trans-sphincteric Anal Fistulas Terminated NCT00929630 Phase 3
13 Gore-BioA Fistula Plug to Treat Transsphincteric Fistulas Terminated NCT01584752 Phase 3
14 A Prospective European Post-Market Clinical Evaluation of the CuraSeal Percutaneous Intraluminal Closure System for Anorectal Fistulas Unknown status NCT02456324 Phase 2
15 An Innovative Treatment for Fistula-in-ano in Crohn Disease : Local Micro Reinjection of Autologous Fat and SVF Unknown status NCT02520843 Phase 1, Phase 2 stromal vascular fraction (SVF)
16 Autologous Stem Cells Derived From Lipoaspirates for the Non-Surgical Treatment of Complex Perianal Fistula Unknown status NCT00115466 Phase 2
17 Success Rate, Continence, and Quality of Life With a Bioprosthetic Plug for Treating Complex Anal Fistula Completed NCT01612195 Phase 2
18 Study to Assess the Safety and Efficacy of Expanded Allogenic Adipose-derived Stem Cells (eASCs) (Cx601), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease. Completed NCT01372969 Phase 1, Phase 2 Cx601
19 Pediatric MSC-AFP Sub-study for Crohn's Fistula Not yet recruiting NCT03449069 Phase 1 MSC-AFP
20 Anal Fistula Plug Versus Endorectal Advancement Flap Unknown status NCT01931371
21 Ligation of Intersphincteric Fistula Tract (LIFT) Procedure Versus Use of an Anal Fistula Plug for Anal Fistula Repair Unknown status NCT00830661
22 Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula Unknown status NCT01929525
23 The Efficacy of Human Acellular Dermal Matrix in the Treatment of Anal Fistula Unknown status NCT00951002
24 Is the Use of Blood Platelets Effective in the Treatment of Difficult Fistulas Related to the Anal Sphincter? Unknown status NCT01615302
25 Surgical Treatment of High Perianal Fistulas Unknown status NCT01997645
26 Anal Crohn Fistula Surgery Unknown status NCT01388257
27 Packing of Perianal Abscess Cavities Trial: A Randomised Multicentre Trial Comparing Packing With Non-packing of the Abscess Cavity Unknown status NCT01739478
28 Trial on Use of Coloshield in Transanal and Anal Surgery Unknown status NCT02579330
29 Surgisis Anal Fistula Plug Study: An Experience in Saudi Arabia Completed NCT00703131
30 Ligation of the Intersphincteric Fistula Tract (LIFT) + Biodesign for Anal Fistula Completed NCT01602081
31 A Randomized Clinical Trial Comparing Surgisis AFP to Advancement Flap for the Repair of Anal Fistulas Completed NCT00545441
32 Treatment of Anal Fistulas Advancement Flap Completed NCT01042821
33 Anal Fistula Treatment Outcome - Collagen Plug Versus Advancement Flap Surgery Completed NCT01021774
34 Management of Fistula in Ano by Kshar Sutra, Para Surgical Procedure. Completed NCT01880398
35 Role of Udumbara Sutra in the Management of Fistula in Ano a Rare Case Study Completed NCT01954225
36 Do Antibiotics Prevent Anal Fistulae Formation? Completed NCT01012843 Amoxicillin-Clavulanate;Placebo
37 A Prospective, Multi-center, Observational Study of the Use of Permacol™ Collagen Paste to Treat Anorectal Fistulas Completed NCT01624350
38 Management of Vaginal Fistula by Kshar Sutra, a Minimally Invasive Treatment Completed NCT01864473
39 Ultrasound Guided Caudal Block for Benign Anal Surgery Completed NCT03345511
40 Multicenter Prospective Evaluation of Radiofrequency for Anal Fistulas Recruiting NCT03131297
41 Treatment of Anal Fistula With Lasercoagulation Recruiting NCT03017898
42 Retrospective Review of the Cook Biodesign® Fistula Plug to Treat Anorectal Fistulas Recruiting NCT03321266
43 Endoscopic Treatment of Complex Anal Fistulas Recruiting NCT02585167
44 VAAFT Vs SETON in the Management of High Peri Anal Fistula Recruiting NCT02313597
45 Randomized Trial on the Effect of Topical Phenytoin on Healing After Fistulotomy Recruiting NCT03096522 Phenytoin 2% spray
46 A Pilot Study to Assess the Efficacy of an Anorectal Fistula Plug With Sealing of the Internal Opening (Curaseal AF) as a Treatment for Perianal Fistula Recruiting NCT03381365
47 Aspiration Treatment of Perianal Abscess Recruiting NCT02585141 Clindamycin
48 Multicenter Study for Diagnosis and Treatment of Perianal Abscesses Recruiting NCT02306382
49 Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences Active, not recruiting NCT02883296
50 LIFT Technique Versus Seton in Management of Anal Fistula Not yet recruiting NCT03311035

Search NIH Clinical Center for Anal Fistula

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Anal Fistula cell therapies at LifeMap Discovery.

Genetic Tests for Anal Fistula

Anatomical Context for Anal Fistula

MalaCards organs/tissues related to Anal Fistula:

38
Skin, Colon, Small Intestine

Publications for Anal Fistula

Articles related to Anal Fistula:

(show top 50) (show all 352)
# Title Authors Year
1
OTSCAr Proctology vs. fistulectomy and primary sphincter reconstruction as a treatment for low trans-sphincteric anal fistula in a randomized controlled pilot trial. ( 29397638 )
2018
2
Silk Fibroin-Based Fibrous Anal Fistula Plug with Drug Delivery Function. ( 29411947 )
2018
3
Video-Assisted Anal Fistula Treatment (VAAFT) in the management of complex anal fistula: single center experience of 224 consecutive patients. ( 29366306 )
2018
4
Video-assisted anal fistula treatment: a high volume unit initial experience. ( 29046093 )
2018
5
Diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging and dynamic contrast-enhanced MRI for assessment of anal fistula activity. ( 29370278 )
2018
6
Root extractive from Daphne genkwa benefits in wound healing of anal fistula through up-regulation of collagen genes in human skin fibroblasts. ( 28396516 )
2017
7
Pathogenesis and persistence of cryptoglandular anal fistula: a systematic review. ( 28620877 )
2017
8
Combined treatment approach to chronic anal fissure with associated anal fistula. ( 29205737 )
2017
9
Sphincter-Sparing Anal Fistula Repair: Are We Getting Better? ( 28891851 )
2017
10
Advancement Flap for Treatment of Complex Cryptoglandular Anal Fistula: Prediction of Therapy Success or Failure Using Anamnestic and Clinical Parameters. ( 28337531 )
2017
11
Transanal opening of intersphincteric space (TROPIS) - A new procedure to treat high complex anal fistula. ( 28259693 )
2017
12
Anal fistula height: is the proportion of sphincteric muscle involved really useful? ( 28510310 )
2017
13
Selected Techniques of Anal Fistula Surgery from Antiquity Through the Early 20th Century Illustrated. ( 28481858 )
2017
14
Discussion of: "What happens after a failed LIFT for anal fistula?" ( 29146002 )
2017
15
Design and Psychometric Evaluation of the Quality of Life in Patients With Anal Fistula Questionnaire. ( 28891853 )
2017
16
Video-Assisted Anal Fistula Treatment (VAAFT) for Complex Anal Fistula: A Preliminary Evaluation in China. ( 28456815 )
2017
17
A novel model of acellular dermal matrix plug for anal fistula treatment. Report of a case and surgical consideration based on first utility in Poland. ( 28905805 )
2017
18
Video-Assisted Anal Fistula Treatment (VAAFT) in Cryptoglandular fistula-in-ano: A systematic review and proportional meta-analysis. ( 28882770 )
2017
19
Randomized clinical trial comparing collagen plug and advancement flap for trans-sphincteric anal fistula. ( 28489253 )
2017
20
Advancement Flap Technique for Anal Fistula in Patients With Crohn's Disease: A Systematic Review of the Literature. ( 29037747 )
2017
21
Synchronous mucinous adenocarcinoma of the recto sigmoid revealed by and seeding an anal fistula. (A case report and review of the literature). ( 28641190 )
2017
22
Pilonidal disease mimicking anterior anal fistula and associated with posterior anal fistula: a two-step surgery. Case report. ( 29442064 )
2017
23
Clinical efficacy of adalimumab versus infliximab and the factors associated with recurrence or aggravation during treatment of anal fistulas in Crohn's disease. ( 28522947 )
2017
24
Anal fistula surgery: what are the patients expecting from the surgeon? ( 28597083 )
2017
25
The best surgical strategy for anal fistula based on a network meta-analysis. ( 29228753 )
2017
26
Comments on the Article, "Selected Techniques of Anal Fistula Surgery from Antiquity Through the Early 20th Century". ( 29112572 )
2017
27
A Systematic review and meta-analysis of the efficacy and safety of video-assisted anal fistula treatment (VAAFT). ( 29052068 )
2017
28
Predictive factors for recurrence of high transsphincteric anal fistula after placement of seton. ( 28601324 )
2017
29
Video-Assisted Anal Fistula Treatment: Pros and Cons of This Minimally Invasive Method for Treatment of Perianal Fistulas. ( 28680443 )
2017
30
Factibility and security study of the PICS-AFa8c plug for the treatment of cryptoglandular anal fistula. ( 28411889 )
2017
31
Patterns of recurrence/persistence of criptoglandular anal fistula after the LIFT procedure. Long-term observacional study. ( 28669408 )
2017
32
Final results of a European, multi-centre, prospective, observational Study of Permacol(a8c) collagen paste injection for the treatment of anal fistula. ( 28493393 )
2017
33
Ozone Treatment for Chronic Anal Fistula: It Is Not Promising. ( 28827904 )
2017
34
What happens after a failed LIFT for anal fistula? ( 29146001 )
2017
35
Pharmacological evaluation for improvement of Kanazawa Sutra, medicinal thread for anal fistula. ( 27900596 )
2016
36
The type of loose seton for complex anal fistula is essential to improve perianal comfort and quality of life. ( 26999764 )
2016
37
Use of a Balloon Rectal Catheter in Magnetic Resonance Imaging of Complex Anal Fistula to Improve Detection of Internal Openings. ( 26953770 )
2016
38
A systematic review of the management of anal fistula in infants. ( 27663698 )
2016
39
Comparison of an anal fistula plug and mucosa advancement flap for complex anal fistulas: a meta-analysis. ( 27680894 )
2016
40
An experience with video-assisted anal fistula treatment (VAAFT) with new insights into the treatment of anal fistulae. ( 27059492 )
2016
41
The Sun King's anal fistula. ( 27554569 )
2016
42
Case of anal fistula with Fournier's gangrene in an obese typeA 2 diabetes mellitus patient. ( 27042282 )
2016
43
Meta-analysis of randomized clinical trials comparing fistulectomy versus fistulotomy for low anal fistula. ( 27777858 )
2016
44
Direct and indirect costs for anal fistula in Sweden. ( 27671704 )
2016
45
The anal fistula plug in Crohn's disease patients with fistula-in-ano: a systematic review. ( 26749385 )
2016
46
Preliminary results of video-assisted anal fistula treatment (VAAFT) in children. ( 26956836 )
2016
47
Video Assisted Anal Fistula Treatment in a Child with Perianal Fistula. ( 26816676 )
2016
48
Response to Re: Long-term results of the cutting seton for high anal fistula. ( 26940185 )
2016
49
Comparison of Endoanal Ultrasound with Clinical Diagnosis in Anal Fistula Assessment. ( 27266219 )
2016
50
Quality of life with anal fistula. ( 27087327 )
2016

Variations for Anal Fistula

Expression for Anal Fistula

Search GEO for disease gene expression data for Anal Fistula.

Pathways for Anal Fistula

GO Terms for Anal Fistula

Cellular components related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MLH1 MSH2

Biological processes related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 MLH1 MSH2
2 activation of MAPKK activity GO:0000186 9.46 EGF KIDINS220
3 mismatch repair GO:0006298 9.43 MLH1 MSH2
4 positive regulation of DNA binding GO:0043388 9.4 EGF MMP9
5 somatic hypermutation of immunoglobulin genes GO:0016446 9.37 MLH1 MSH2
6 isotype switching GO:0045190 9.32 MLH1 MSH2
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.26 MLH1 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MLH1 MSH2
9 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MLH1 MSH2
10 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Anal Fistula according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Anal Fistula

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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