MCID: ANL017
MIFTS: 45

Anal Squamous Cell Carcinoma malady

Skin, Cancer categories

Summaries for Anal Squamous Cell Carcinoma

Sources:
8Disease Ontology, 33MalaCards
See all sources

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Disease Ontology:8 An anal carcinoma that arises near the squamocolumnar junction.

MalaCards: Anal Squamous Cell Carcinoma, also known as epidermoid anal carcinoma, is related to squamous cell carcinoma and squamous cell papilloma. An important gene associated with Anal Squamous Cell Carcinoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are PI3K / Akt Signaling and AKT phosphorylates targets in the cytosol. The compounds vincristine and guanine have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and tongue, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Anal Squamous Cell Carcinoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin


Aliases & Descriptions:

anal squamous cell carcinoma 8 61
epidermoid anal carcinoma 8


External Ids:

Disease Ontology8 DOID:5525
SNOMED-CT57 255084004
NCIt40 C9161

Related Diseases for Anal Squamous Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Anal Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.6TP53, AKT1, MDM2, TP63
2squamous cell papilloma10.6
3systemic lupus erythematosus10.2
4peutz-jeghers syndrome10.2
5vulva squamous cell carcinoma10.2
6peutz–jeghers syndrome10.2
7giant cell glioblastoma10.0MDM2
8chondrosarcoma10.0MDM2
9anaplastic oligodendroglioma10.0MDM2
10benign meningioma10.0MDM2
11dermatofibrosarcoma10.0MDM2
12prion disease10.0AKT1
13malignant mesothelioma10.0TP63
14myoepithelioma10.0TP63
15ductal carcinoma in situ10.0TP53
16cholangiocarcinoma10.0TP53
17kidney cancer10.0TP53
18brain cancer10.0TP53
19lynch syndrome10.0TP53
20fibrosarcoma10.0AKT1, MDM2
21ischemia10.0DMD, AKT1
22chronic granulomatous disease10.0AKT1, DMD
23esophageal cancer10.0TP53
24thymoma10.0TP63, AKT1
25pleomorphic adenoma10.0MDM2, TP63
26ulcerative colitis10.0TP53
27osteosarcoma10.0MDM2, TP53
28ataxia telangiectasia10.0TP53, MDM2
29cervical cancer10.0TP53, MDM2
30li-fraumeni syndrome10.0TP53, MDM2
31breast cancer, invasive ductal10.0TP53, MDM2
32skin cancer10.0AKT1, TP53
33thyroid cancer10.0TP53, AKT1
34oral cancer10.0TP53, MDM2
35papilloma10.0TP63, TP53
36medulloblastoma10.0AKT1, TP53
37adenoma10.0TP63, TP53
38bladder carcinoma10.0TP53, MDM2
39endometrial carcinoma10.0TP63, TP53
40neuroblastoma10.0TP53, AKT1
41pancreatic cancer10.0TP53, AKT1
42actinic keratosis10.0TP53, TP63
43nasopharynx carcinoma10.0TP53, MDM2
44retinoblastoma10.0MDM2, AKT1, TP53
45anaplastic astrocytoma10.0MDM2, TP53
46leiomyosarcoma10.0TP63, TP53, MDM2
47transitional cell carcinoma10.0MDM2, TP63, TP53
48non-small cell lung carcinoma10.0TP63, MDM2, TP53
49colon cancer10.0AKT1, MDM2, TP53
50lung cancer10.0MDM2, TP63, TP53

Graphical network of the top 20 diseases related to Anal Squamous Cell Carcinoma:



Diseases related to anal squamous cell carcinoma

Clinical Features for Anal Squamous Cell Carcinoma

Drugs & Therapeutics for Anal Squamous Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Anal Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Anal Squamous Cell Carcinoma

Search NIH Clinical Center for Anal Squamous Cell Carcinoma

Search CenterWatch for Anal Squamous Cell Carcinoma

Genetic Tests for Anal Squamous Cell Carcinoma

Anatomical Context for Anal Squamous Cell Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anal Squamous Cell Carcinoma:

33
Skin, Ovary, Tongue, Lymph node, Lung, Cervix, T cells, B cells, Endothelial

Animal Models for Anal Squamous Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Anal Squamous Cell Carcinoma

Sources:
51PubMed
See all sources

Articles related to Anal Squamous Cell Carcinoma:

(show top 50)    (show all 469)
idTitleAuthorsYear
1
Distant metastasis in p16-positive oropharyngeal squamous cell carcinoma: A critical analysis of patterns and outcomes. (24211084)
2014
2
Oral squamous cell carcinoma in patients twenty years of age or younger - Review and analysis of 186 reported cases. (24296165)
2014
3
The diagnostic value of methylated DNA in laryngeal squamous cell carcinoma: meta-analysis. (23466793)
2013
4
Education and Imaging. Gastrointestinal: advanced untreated anal canal squamous cell carcinoma. (23692575)
2013
5
Invasive and prognostic significance of pRB in esophageal squamous cell carcinoma: a meta-analysis. (23383595)
2013
6
In vitro analysis of photosensitizer accumulation for assessment of applicability of fluorescence diagnosis of squamous cell carcinoma of epidermolysis bullosa patients. (23509735)
2013
7
Immunohistochemical analysis of TIMP-3 and MMP-9 in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma. (24011615)
2013
8
Adjuvant chemotherapy versus surgery alone for esophageal squamous cell carcinoma: a meta-analysis of randomized controlled trials and nonrandomized studies. (23621119)
2013
9
Immunohistochemical analysis of mast cell infiltrates and microvessel density in oral squamous cell carcinoma. (24375042)
2013
10
Immunohistochemical analysis of O(6)-methylguanine-DNA methyltransferase in human melanoma in comparison with skin squamous cell carcinoma. (23460078)
2013
11
Retrospective analysis of prognostic factors in 205 patients with laryngeal squamous cell carcinoma who underwent surgical treatment. (23593169)
2013
12
Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer-assisted analysis on TMA sections. (23438150)
2013
13
Correction: Retrospective Analysis of Prognostic Factors in 205 Patients with Laryngeal Squamous Cell Carcinoma Who Underwent Surgical Treatment. (24358079)
2013
14
Early clinical outcomes of anal squamous cell carcinoma treated with concurrent chemoradiotherapy with 5-Fluorouracil plus mitomycin C in Japanese patients: experience at a single institution. (22717459)
2012
15
Analysis on expression of survivin and PTEN in vocal cords polyps, papilloma of larynx and laryngeal squamous cell carcinoma]. (23167185)
2012
16
Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma. (22705009)
2012
17
Analysis of HER2 gene amplification and protein expression in esophageal squamous cell carcinoma. (21318736)
2012
18
Analysis of thermochemotherapy-induced apoptosis and the protein expressions of Bcl-2 and Bax in maxillofacial squamous cell carcinomas. (21104343)
2011
19
Subungual keratoacanthoma: analysis of cell proliferation and copy number variation of oncogenes compared with periungual squamous cell carcinoma. (20456385)
2011
20
Analysis on the clinical features of 22 basaloid squamous cell carcinoma of the lung. (21269455)
2011
21
Comparative proteomic analysis of the esophageal squamous carcinoma cell line EC109 and its multi-drug resistant subline EC109/CDDP. (19956855)
2010
22
Molecular analysis of oral squamous cell carcinoma: a tissue microarray study. (20448381)
2010
23
Establishment and characterization of the human SaTM-1 anal canal squamous cell carcinoma cell line derived from lymph node metastasis. (19724886)
2009
24
Paraneoplastic hypercalcemia caused by an invasive squamous cell carcinoma arising from a giant anal condyloma acuminatum. (18688619)
2009
25
Analysis of 724 cases of primary head and neck squamous cell carcinoma (HNSCC) with a focus on young patients and p53 immunolocalization. (19359212)
2009
26
VEGF and ki 67 expression in squamous cell carcinoma of the tongue: An immunohistochemical and computerized image analysis study. (18804402)
2009
27
TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: a case-control analysis in a Chinese population. (17680270)
2008
28
Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis. (18617144)
2008
29
Comparative analysis of c-erbB-2 (HER-2/neu) in squamous cell carcinoma of the tongue: does over-expression exist? And what is its correlation with traditional diagnostic parameters? (18251938)
2008
30
Analysis of the methylation status of genes up-regulated by the demethylating agent, 5-aza-2'-deoxycytidine, in esophageal squamous cell carcinoma. (18636205)
2008
31
Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. (18816083)
2008
32
Gene expression profiling of esophageal cancer: comparative analysis of Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma. (17236199)
2007
33
Identification of differentially expressed, tumor-associated proteins in oral squamous cell carcinoma by proteomic analysis. (16568407)
2006
34
Beta-catenin gene analysis in oral squamous cell carcinoma. (16848985)
2005
35
INK4-ARF and p53 mutations in metastatic cutaneous squamous cell carcinoma: case report and archival study on the use of Ink4a-ARF and p53 mutation analysis in identification of the corresponding primary tumor. (15613867)
2005
36
XX sex reversal, palmoplantar keratoderma, and predisposition to squamous cell carcinoma: genetic analysis in one family. (16158431)
2005
37
Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas. (15041222)
2004
38
Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues. (12874860)
2003
39
Prognostic significance of biomarkers in squamous cell carcinoma of the tongue: multivariate analysis. (12501167)
2003
40
Distinct site-specific oncoprotein overexpression in head and neck squamous cell carcinoma: a tissue microarray analysis. (14666705)
2003
41
Detection of the human papillomavirus and analysis of the TP53 polymorphism of exon 4 at codon 72 in penile squamous cell carcinomas. (12628849)
2003
42
Anal squamous cell carcinoma in a patient with Peutz-Jeghers syndrome. (11281174)
2001
43
Mutational analyses of candidate genes in human squamous cell carcinomas. (10201760)
1999
44
Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin. (9496908)
1998
45
Analysis of p53 serum antibodies in patients with head and neck squamous cell carcinoma. (8780633)
1996
46
Pleomorphic (giant and spindle cell) carcinoma is genetically distinct from adenocarcinoma and squamous cell carcinoma by K-ras-2 and p53 analysis. (8853037)
1996
47
Treatment of invasive squamous cell carcinoma complicating anal Buschke-LAPwenstein tumor: a case history. (7544255)
1995
48
An alternative treatment of anal squamous cell carcinoma: combined radiotherapy and chemotherapy. (8441261)
1993
49
Analysis of invasive squamous cell carcinoma of the vulva and vulvar intraepithelial neoplasia for the presence of human papillomavirus DNA. (2030868)
1991
50
CERVICAL CARCINOMA IN SITU AND ANAL SQUAMOUS-CELL CARCINOMA FOLLOWING RADIATION THERAPY FOR SQUAMOUS-CELL CARCINOMA OF CERVIX. (14069947)
1963

Genetic Variations for Anal Squamous Cell Carcinoma

Expression for genes affiliated with Anal Squamous Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anal Squamous Cell Carcinoma

Search GEO for disease gene expression data for Anal Squamous Cell Carcinoma.

Pathways for genes affiliated with Anal Squamous Cell Carcinoma

Sources:
4Cell Signaling Technology, 54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 30KEGG, 53R&D Systems, 56SinoBiological, 60Tocris Bioscience, 50PharmGKB
See all sources

Pathways related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MDM2, AKT1
29.5MDM2, AKT1
39.5MDM2, AKT1
49.2TP53, MDM2
59.2TP53, MDM2
69.2MDM2, TP53
79.2TP53, MDM2
8
Transcription P53 signaling pathway
Hide members
9.2MDM2, TP53
99.1AKT1, TP53
10
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
Hide members
9.1TP53, AKT1
119.1AKT1, TP53
12
Hide members
9.1TP53, AKT1
13
Hide members
9.1AKT1, TP53
149.1TP53, AKT1
15
Hide members
9.0TP53, TP63
16
Hide members
8.7MDM2, AKT1, TP53
178.7TP53, MDM2, AKT1
188.7AKT1, TP53, MDM2
198.7TP53, AKT1, MDM2
208.7TP53, MDM2, AKT1
218.7MDM2, TP53, AKT1
228.7TP53, AKT1, MDM2
238.7AKT1, TP53, MDM2
24
Hide members
8.7TP53, AKT1, MDM2
258.7TP53, AKT1, MDM2
268.7TP53, AKT1, MDM2
278.7AKT1, MDM2, TP53
288.7MDM2, AKT1, TP53
29
Hide members
8.7AKT1, TP53, MDM2
308.7MDM2, TP53, AKT1
31
Hide members
8.7TP53, AKT1, MDM2
32
Hide members
8.7TP53, AKT1, MDM2
33
Hide members
8.7AKT1, MDM2, TP53
34
Hide members
8.7AKT1, TP53, MDM2
358.7TP53, MDM2, AKT1
36
Hide members
8.7TP53, AKT1, MDM2
37
Hide members
8.7MDM2, AKT1, TP53
38
Hide members
8.7MDM2, AKT1, TP53
398.6TP53, MDM2, TP63
408.6TP53, TP63, MDM2
418.6TP63, TP53, MDM2

Compounds for genes affiliated with Anal Squamous Cell Carcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1vincristine45 50 1112.4AKT1
2guanine45 11 2412.4AKT1
3phosphorothioate459.9DMD, MDM2
410-hydroxycamptothecin459.6TP53, MDM2
5bpde459.6TP53, MDM2
6chlorambucil45 1110.6MDM2, TP53
7aflatoxin b145 2410.6TP53, MDM2
82-chlorodeoxyadenosine459.6TP53, MDM2
9dutp459.5TP53, MDM2
10methylmethanesulfonate459.5MDM2, TP53
11bcnu459.5AKT1, TP53
12fludarabine45 1110.5TP53, MDM2
13hematoxylin459.5TP63, DMD
14roscovitine459.5TP53, MDM2
15sodium arsenite459.5TP53, AKT1
16benzo(a)pyrene459.5MDM2, TP53
17indole-3-carbinol459.5AKT1, TP53
18leptomycin b45 6010.5TP53, MDM2
19flavopiridol45 1110.4TP53, MDM2
20melphalan45 1110.4TP53, MDM2
21glycogen45 2410.3MDM2, AKT1, DMD
22c2ceramide459.3TP53, AKT1
23vinblastine45 50 1111.3TP53, MDM2
24carboplatin45 50 1111.2MDM2, TP53
25lactacystin459.1AKT1, TP53, MDM2
26sp 60012545 6010.1TP53, AKT1, MDM2
27adriamycin459.1AKT1, TP53, MDM2
28mg 13245 6010.1MDM2, AKT1, TP53
29irinotecan45 50 1111.1MDM2, TP53
30curcumin459.1MDM2, TP53, AKT1
31arsenite45 2410.1MDM2, AKT1, TP53
32etoposide45 50 60 1112.1MDM2, TP53, AKT1
33paclitaxel45 50 1111.1AKT1, MDM2, TP53
34ly294002459.0AKT1, TP53, MDM2
35actinomycin d459.0TP53, AKT1, MDM2
36noxa459.0MDM2, TP63, TP53
37mitomycin c459.0MDM2, TP53, TP63
38proline459.0TP53, DMD, MDM2
39thymidine45 249.9TP53, TP63, MDM2
40cycloheximide458.9MDM2, TP53, AKT1
41progesterone45 60 29 11 2412.6TP53, TP63, MDM2
42doxorubicin45 50 1110.5MDM2, AKT1, TP63, TP53
43paraffin458.5TP63, AKT1, TP53, MDM2
44cisplatin45 50 60 1111.5MDM2, AKT1, TP63, TP53
45vegf458.5TP63, MDM2, AKT1, TP53
46tyrosine458.5DMD, AKT1, TP63, MDM2
47estrogen458.5TP63, MDM2, AKT1, TP53
48serine458.4DMD, MDM2, AKT1, TP53
49h2o2458.4TP53, MDM2, AKT1
50arginine458.0TP53, TP63, AKT1, DMD, MDM2

GO Terms for genes affiliated with Anal Squamous Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.0TP53, TP63
2nuclear bodyGO:0166048.9TP53, MDM2
3protein complexGO:0432348.7TP53, DMD, MDM2
4nucleoplasmGO:0056548.0MDM2, AKT1, TP63, TP53
5cytosolGO:0058297.5MDM2, DMD, AKT1, TP63, TP53

Biological processes related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:0324369.6MDM2, AKT1
2response to antibioticGO:0466779.4MDM2, TP53
3protein import into nucleus, translocationGO:0000609.4TP53, AKT1
4negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.4AKT1, MDM2
5mitotic G1 DNA damage checkpointGO:0315719.3TP53, TP63
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.3TP53, TP63
7response to X-rayGO:0101659.3TP63, TP53
8intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.3TP53, TP63
9cell agingGO:0075699.3TP63, TP53
10response to gamma radiationGO:0103329.3TP53, TP63
11cellular protein localizationGO:0346139.2TP53, DMD
12neuron apoptotic processGO:0514029.2TP53, TP63
13cellular response to UVGO:0346449.2TP53, TP63
14intrinsic apoptotic signaling pathwayGO:0971939.1TP53, AKT1
15cellular response to hypoxiaGO:0714569.0TP53, AKT1, MDM2
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069778.9MDM2, TP53
17negative regulation of transcription, DNA-dependentGO:0458928.6MDM2, TP63, TP53
18negative regulation of transcription from RNA polymerase II promoterGO:0001228.6TP53, TP63, MDM2
19negative regulation of apoptotic processGO:0430668.4MDM2, AKT1, TP63, TP53

Molecular functions related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.0TP53, TP63
2damaged DNA bindingGO:0036848.7TP53, TP63
3p53 bindingGO:0020398.6TP53, TP63, MDM2
4enzyme bindingGO:0198998.6MDM2, AKT1, TP53
5identical protein bindingGO:0428028.1TP53, TP63, AKT1, MDM2

Products for genes affiliated with Anal Squamous Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anal Squamous Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet