MCID: ANL017
MIFTS: 46

Anal Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Anal Squamous Cell Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An anal carcinoma that arises near the squamocolumnar junction.

MalaCards: Anal Squamous Cell Carcinoma, also known as epidermoid anal carcinoma, is related to squamous cell carcinoma and papilloma. An important gene associated with Anal Squamous Cell Carcinoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are PI3K / Akt Signaling and AKT phosphorylates targets in the cytosol. The compounds vincristine and guanine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and skin, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Anal Squamous Cell Carcinoma

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

anal squamous cell carcinoma 8 60
epidermoid anal carcinoma 8


External Ids:

Disease Ontology8 DOID:5525
SNOMED-CT56 255084004
NCIt39 C9161

Related Diseases for Anal Squamous Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anal Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.5TP53, AKT1, MDM2, TP63
2papilloma30.5TP63, TP53
3anal carcinoma in situ10.5
4in situ carcinoma10.5
5squamous cell papilloma10.4
6cerebritis10.2
7systemic lupus erythematosus10.2
8peutz-jeghers syndrome10.2
9cervical squamous cell carcinoma10.2
10cervicitis10.2
11dermatitis10.2
12inflammatory bowel disease10.2
13lupus erythematosus10.2
14giant cell glioblastoma10.0MDM2
15chondrosarcoma10.0MDM2
16anaplastic oligodendroglioma10.0MDM2
17benign meningioma10.0MDM2
18dermatofibrosarcoma10.0MDM2
19prion disease10.0AKT1
20malignant mesothelioma10.0TP63
21myoepithelioma10.0TP63
22ductal carcinoma in situ10.0TP53
23cholangiocarcinoma10.0TP53
24kidney cancer10.0TP53
25brain cancer10.0TP53
26lynch syndrome10.0TP53
27fibrosarcoma10.0AKT1, MDM2
28ischemia10.0DMD, AKT1
29chronic granulomatous disease10.0AKT1, DMD
30esophageal cancer10.0TP53
31thymoma10.0TP63, AKT1
32pleomorphic adenoma10.0MDM2, TP63
33ulcerative colitis10.0TP53
34osteosarcoma10.0MDM2, TP53
35ataxia telangiectasia10.0TP53, MDM2
36cervical cancer10.0TP53, MDM2
37li-fraumeni syndrome10.0TP53, MDM2
38breast cancer, invasive ductal10.0TP53, MDM2
39thyroid cancer10.0TP53, AKT1
40oral cancer10.0TP53, MDM2
41medulloblastoma10.0AKT1, TP53
42adenoma10.0TP63, TP53
43bladder carcinoma10.0TP53, MDM2
44endometrial carcinoma10.0TP63, TP53
45neuroblastoma10.0TP53, AKT1
46pancreatic cancer10.0TP53, AKT1
47actinic keratosis10.0TP53, TP63
48nasopharynx carcinoma10.0TP53, MDM2
49retinoblastoma10.0MDM2, AKT1, TP53
50anaplastic astrocytoma10.0MDM2, TP53

Graphical network of the top 20 diseases related to Anal Squamous Cell Carcinoma:



Diseases related to anal squamous cell carcinoma

Clinical Features for Anal Squamous Cell Carcinoma

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Drugs & Therapeutics for Anal Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Anal Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Anal Squamous Cell Carcinoma

Search NIH Clinical Center for Anal Squamous Cell Carcinoma

Search CenterWatch for Anal Squamous Cell Carcinoma

Genetic Tests for Anal Squamous Cell Carcinoma

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Anatomical Context for Anal Squamous Cell Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Anal Squamous Cell Carcinoma:

32
Lymph node, T cells, Skin, Cervix

Animal Models for Anal Squamous Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anal Squamous Cell Carcinoma:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2DMD
2MP:00053699.0TP53, DMD, MDM2
3MP:00053798.6TP53, AKT1, DMD
4MP:00053708.4TP53, AKT1, DMD, MDM2
5MP:00053718.3TP53, TP63, DMD, MDM2
6MP:00020068.3MDM2, AKT1, TP63, TP53
7MP:00053818.2TP53, TP63, DMD, MDM2
8MP:00053888.2TP53, TP63, AKT1, DMD
9MP:00107718.0MDM2, AKT1, TP63, TP53
10MP:00053907.9MDM2, DMD, AKT1, TP63, TP53
11MP:00028737.8MDM2, DMD, AKT1, TP63, TP53
12MP:00053897.8TP53, TP63, AKT1, DMD, MDM2
13MP:00053857.8MDM2, DMD, AKT1, TP63, TP53
14MP:00053867.8TP53, TP63, AKT1, DMD, MDM2
15MP:00053877.8MDM2, DMD, AKT1, TP63, TP53
16MP:00053807.8MDM2, AKT1, TP63, TP53
17MP:00053847.7MDM2, DMD, AKT1, TP63, TP53
18MP:00053787.6MDM2, DMD, AKT1, TP63, TP53
19MP:00107687.5TP53, TP63, AKT1, DMD, MDM2

Publications for Anal Squamous Cell Carcinoma

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Sources:
50PubMed
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Articles related to Anal Squamous Cell Carcinoma:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Aggressive strategy for the treatment of synchronous metastatic anal squamous cell carcinoma. (23958077)
2013
2
Outcome of salvage surgery for anal squamous cell carcinoma. (23522325)
2013
3
Education and Imaging. Gastrointestinal: advanced untreated anal canal squamous cell carcinoma. (23692575)
2013
4
When rectal bleeding is serious: anal squamous cell carcinoma in two intravenous cyclophosphamide treated systemic lupus erythematosus patients with human papilloma virus infection. (23893826)
2013
5
Systematic review of sentinel lymph node biopsy in anal squamous cell carcinoma. (23872032)
2013
6
Salvage Surgery for Residual Primary and Locally Recurrent Anal Squamous Cell Carcinoma After Chemoradiotherapy in HIV-positive Individuals. (24242676)
2013
7
Can radiobiological parameters derived from squamous cell carcinoma of the head and neck be used to predict local control in anal cancer treated with chemoradiation? (23239699)
2013
8
Clinicopathological analysis of basal cell carcinoma of the anal region and its distinction from basaloid squamous cell carcinoma. (23599161)
2013
9
Cutaneous vulvar metastases in a patient with anal squamous cell carcinoma. (23617081)
2013
10
EGFR and K-ras gene mutation status in squamous cell anal carcinoma: a role for concurrent radiation and EGFR inhibitors? (23093229)
2012
11
Development of cerebral metastasis after medical and surgical treatment of anal squamous cell carcinoma. (23091760)
2012
12
Early clinical outcomes of anal squamous cell carcinoma treated with concurrent chemoradiotherapy with 5-Fluorouracil plus mitomycin C in Japanese patients: experience at a single institution. (22717459)
2012
13
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients. (23033134)
2012
14
Current treatment of anal squamous cell carcinoma. (23116582)
2012
15
Advanced anal squamous cell carcinoma -- radiotherapy or surgery? (23116837)
2012
16
Metachronous splenic metastasis in an anal squamous cell carcinoma. (21563664)
2011
17
Twenty-year experience in the management of squamous cell anal canal carcinoma with interstitial brachytherapy. (21775274)
2011
18
The prognostic significance of tumor human papillomavirus status for patients with anal squamous cell carcinoma treated with combined chemoradiotherapy. (21128253)
2011
19
The role of A^a8,fluoro-deoxy glucose combined position emission and computed tomography in the clinical management of anal squamous cell carcinoma. (20070338)
2011
20
Chemoradiation for anal squamous cell carcinoma: case report. (22018257)
2011
21
Radiation therapy of recurrent anal squamous cell carcinoma in-situ: a case report. (20181236)
2010
22
Immunosuppressive disorders and risk of anal squamous cell carcinoma: a nationwide cohort study in Denmark, 1978-2005. (19960431)
2010
23
Establishment and characterization of the human SaTM-1 anal canal squamous cell carcinoma cell line derived from lymph node metastasis. (19724886)
2009
24
Paraneoplastic hypercalcemia caused by an invasive squamous cell carcinoma arising from a giant anal condyloma acuminatum. (18688619)
2009
25
K-ras status in squamous cell anal carcinoma (SCC): it's time for target-oriented treatment? (19727729)
2009
26
Current therapeutic strategies for anal squamous cell carcinoma in Japan. (19856049)
2009
27
Evaluation by 18F-FDG-PET of patients with anal squamous cell carcinoma. (19330178)
2009
28
Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma. (18787619)
2008
29
Invasive anal squamous-cell carcinoma in the HIV-positive patient: outcome in the era of highly active antiretroviral therapy. (18066626)
2008
30
Chemoradiotherapy with or without consolidation chemotherapy using cisplatin and 5-fluorouracil in anal squamous cell carcinoma: long-term results in 31 patients. (18194582)
2008
31
Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma. (17721920)
2007
32
Squamous cell carcinoma arising from recurrent anal fistula. (17878704)
2007
33
Letter to the editor concerning "HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN)" by Varnai et al. (Int J Colorectal Dis 21:135-142, 2006). (16703315)
2007
34
Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. (17255774)
2007
35
Human papillomavirus (HPV), DNA aberrations and cell cycle progression in anal squamous cell carcinoma patients. (18214063)
2007
36
Elevated anal squamous cell carcinoma risk associated with benign inflammatory anal lesions. (16299038)
2006
37
Histological features of human papilloma virus 16 and its association with the development and progression of anal squamous cell carcinoma. (16998682)
2006
38
Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification. (16648870)
2006
39
Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. (16740757)
2006
40
DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. (16166431)
2005
41
Outcome analysis of HIV-positive patients with anal squamous cell carcinoma. (11330577)
2001
42
Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma. (11598481)
2001
43
Treatment of squamous cell anal canal carcinoma with pulsed dose rate brachytherapy. Feasibility study of a French cooperative group. (10435803)
1999
44
Amplification and expression of the cyclin D1 gene in anal and esophageal squamous cell carcinomas. (9042789)
1997
45
An alternative treatment of anal squamous cell carcinoma: combined radiotherapy and chemotherapy. (8441261)
1993
46
An unusual case of pruritus ani. Anal margin squamous cell carcinoma (SCC). (1497370)
1992
47
Anal squamous cell carcinoma arising on radio-dermatitis cured with chemotherapy alone: case report. (3660479)
1987
48
Human papillomavirus type 16 DNA in anal squamous cell carcinoma. (2885526)
1987
49
Effectiveness of cisplatin in the treatment of anal squamous cell carcinoma. (4040426)
1985
50
CERVICAL CARCINOMA IN SITU AND ANAL SQUAMOUS-CELL CARCINOMA FOLLOWING RADIATION THERAPY FOR SQUAMOUS-CELL CARCINOMA OF CERVIX. (14069947)
1963

Genetic Variations for Anal Squamous Cell Carcinoma

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Expression for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anal Squamous Cell Carcinoma

Search GEO for disease gene expression data for Anal Squamous Cell Carcinoma.

Pathways for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
4Cell Signaling Technology, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems, 55SinoBiological, 59Tocris Bioscience, 49PharmGKB
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Pathways related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5AKT1, MDM2
29.5MDM2, AKT1
39.5AKT1, MDM2
49.2TP53, MDM2
59.2TP53, MDM2
69.2MDM2, TP53
79.2TP53, MDM2
8
Transcription P53 signaling pathway
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9.2TP53, MDM2
99.1AKT1, TP53
10
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
Hide members
9.1TP53, AKT1
119.1AKT1, TP53
12
Hide members
9.1TP53, AKT1
13
Hide members
9.1TP53, AKT1
149.1TP53, AKT1
15
Hide members
9.0TP53, TP63
16
Hide members
8.7TP53, AKT1, MDM2
178.7MDM2, AKT1, TP53
188.7MDM2, AKT1, TP53
198.7MDM2, AKT1, TP53
208.7TP53, AKT1, MDM2
218.7TP53, AKT1, MDM2
228.7MDM2, AKT1, TP53
238.7MDM2, AKT1, TP53
24
Hide members
8.7TP53, AKT1, MDM2
258.7MDM2, AKT1, TP53
268.7TP53, AKT1, MDM2
278.7MDM2, AKT1, TP53
288.7TP53, AKT1, MDM2
29
Hide members
8.7MDM2, AKT1, TP53
308.7TP53, AKT1, MDM2
31
Hide members
8.7TP53, AKT1, MDM2
32
Hide members
8.7TP53, AKT1, MDM2
338.7MDM2, AKT1, TP53
34
Hide members
8.7TP53, AKT1, MDM2
35
Hide members
8.7MDM2, AKT1, TP53
36
Hide members
8.7TP53, AKT1, MDM2
37
Hide members
8.7MDM2, AKT1, TP53
38
Hide members
8.7TP53, AKT1, MDM2
398.6MDM2, TP63, TP53
408.6TP53, TP63, MDM2
418.6TP53, TP63, MDM2

Compounds for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.4AKT1
2guanine44 11 2412.4AKT1
3phosphorothioate449.9DMD, MDM2
410-hydroxycamptothecin449.6TP53, MDM2
5bpde449.6TP53, MDM2
6chlorambucil44 1110.6MDM2, TP53
7aflatoxin b144 2410.6TP53, MDM2
82-chlorodeoxyadenosine449.6TP53, MDM2
9dutp449.5TP53, MDM2
10methylmethanesulfonate449.5MDM2, TP53
11bcnu449.5AKT1, TP53
12fludarabine44 1110.5TP53, MDM2
13hematoxylin449.5TP63, DMD
14roscovitine449.5TP53, MDM2
15sodium arsenite449.5TP53, AKT1
16benzo(a)pyrene449.5MDM2, TP53
17indole-3-carbinol449.5AKT1, TP53
18leptomycin b44 5910.5TP53, MDM2
19flavopiridol44 1110.4TP53, MDM2
20melphalan44 1110.4TP53, MDM2
21glycogen44 2410.3MDM2, AKT1, DMD
22c2ceramide449.3TP53, AKT1
23vinblastine44 49 1111.3TP53, MDM2
24carboplatin44 49 1111.2MDM2, TP53
25lactacystin449.1AKT1, TP53, MDM2
26sp 60012544 5910.1TP53, AKT1, MDM2
27adriamycin449.1AKT1, TP53, MDM2
28mg 13244 5910.1MDM2, AKT1, TP53
29irinotecan44 49 1111.1MDM2, TP53
30curcumin449.1MDM2, TP53, AKT1
31arsenite44 2410.1MDM2, AKT1, TP53
32etoposide44 49 59 1112.1MDM2, TP53, AKT1
33paclitaxel44 49 1111.1AKT1, MDM2, TP53
34ly294002449.0AKT1, TP53, MDM2
35actinomycin d449.0TP53, AKT1, MDM2
36noxa449.0MDM2, TP63, TP53
37mitomycin c449.0MDM2, TP53, TP63
38proline449.0TP53, DMD, MDM2
39thymidine44 249.9TP53, TP63, MDM2
40cycloheximide448.9MDM2, TP53, AKT1
41progesterone44 59 28 11 2412.6TP53, TP63, MDM2
42doxorubicin44 49 1110.5MDM2, AKT1, TP63, TP53
43paraffin448.5TP63, AKT1, TP53, MDM2
44cisplatin44 49 59 1111.5MDM2, AKT1, TP63, TP53
45vegf448.5TP63, MDM2, AKT1, TP53
46tyrosine448.5DMD, AKT1, TP63, MDM2
47estrogen448.5TP63, MDM2, AKT1, TP53
48serine448.4DMD, MDM2, AKT1, TP53
49h2o2448.4TP53, MDM2, AKT1
50arginine448.0TP53, TP63, AKT1, DMD, MDM2

GO Terms for genes affiliated with Anal Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.0TP53, TP63
2nuclear bodyGO:0166048.9TP53, MDM2
3protein complexGO:0432348.7TP53, DMD, MDM2
4nucleoplasmGO:0056548.0MDM2, AKT1, TP63, TP53
5cytosolGO:0058297.5MDM2, DMD, AKT1, TP63, TP53

Biological processes related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:0324369.6MDM2, AKT1
2response to antibioticGO:0466779.4MDM2, TP53
3protein import into nucleus, translocationGO:0000609.4TP53, AKT1
4negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.4AKT1, MDM2
5mitotic G1 DNA damage checkpointGO:0315719.3TP53, TP63
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.3TP53, TP63
7response to X-rayGO:0101659.3TP63, TP53
8intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.3TP53, TP63
9cell agingGO:0075699.3TP63, TP53
10response to gamma radiationGO:0103329.3TP53, TP63
11cellular protein localizationGO:0346139.2TP53, DMD
12neuron apoptotic processGO:0514029.2TP53, TP63
13cellular response to UVGO:0346449.2TP53, TP63
14intrinsic apoptotic signaling pathwayGO:0971939.1TP53, AKT1
15cellular response to hypoxiaGO:0714569.0TP53, AKT1, MDM2
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069778.9MDM2, TP53
17negative regulation of transcription, DNA-dependentGO:0458928.6MDM2, TP63, TP53
18negative regulation of transcription from RNA polymerase II promoterGO:0001228.6TP53, TP63, MDM2
19negative regulation of apoptotic processGO:0430668.4MDM2, AKT1, TP63, TP53

Molecular functions related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.0TP53, TP63
2damaged DNA bindingGO:0036848.7TP53, TP63
3p53 bindingGO:0020398.6TP53, TP63, MDM2
4enzyme bindingGO:0198998.6MDM2, AKT1, TP53
5identical protein bindingGO:0428028.1TP53, TP63, AKT1, MDM2

Products for genes affiliated with Anal Squamous Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anal Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet