MCID: ANL017
MIFTS: 47

Anal Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases categories
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Summaries for Anal Squamous Cell Carcinoma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 An anal carcinoma that arises near the squamocolumnar junction.

MalaCards: Anal Squamous Cell Carcinoma, also known as epidermoid anal carcinoma, is related to papilloma and cerebritis. An important gene associated with Anal Squamous Cell Carcinoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are PI3K / Akt Signaling and Androgen receptor signaling pathway. The compounds 10-hydroxycamptothecin and bpde have been mentioned in the context of this disorder. Affiliated tissues include t cells, lymph node and cervix, and related mouse phenotypes are tumorigenesis and adipose tissue.

Aliases & Classifications for Anal Squamous Cell Carcinoma

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8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

anal squamous cell carcinoma 8 62
epidermoid anal carcinoma 8


External Ids:

Disease Ontology8 DOID:5525
SNOMED-CT58 255084004
NCIt40 C9161

Related Diseases for Anal Squamous Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anal Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma30.7TP63, TP53
2cerebritis10.3
3systemic lupus erythematosus10.3
4peutz-jeghers syndrome10.3
5cervicitis10.3
6dermatitis10.3
7inflammatory bowel disease10.3
8lupus erythematosus10.3
9giant cell glioblastoma10.1MDM2
10prion disease10.1AKT1
11li-fraumeni syndrome10.1TP53, MDM2
12breast cancer, invasive ductal10.0MDM2, TP53
13liposarcoma10.0MDM2, TP53
14anaplastic astrocytoma10.0TP53, MDM2
15bladder carcinoma10.0MDM2, TP53
16oligodendroglioma10.0MDM2, TP53
17esophageal cancer10.0TP53, MDM2
18pleomorphic adenoma10.0TP63, MDM2
19actinic keratosis10.0TP63, TP53
20oral cancer10.0MDM2, TP53
21nasopharynx carcinoma10.0TP53, MDM2
22endometrial carcinoma10.0TP63, TP53
23laryngeal squamous cell carcinoma10.0TP53, TP63
24thymoma10.0AKT1, TP63
25ataxia telangiectasia10.0TP53, MDM2
26basal cell carcinoma10.0TP63, TP53
27multiple myeloma10.0TP53, AKT1
28glioblastoma multiforme10.0TP53, MDM2
29thyroid cancer10.0TP53, AKT1
30chronic granulomatous disease10.0DMD, AKT1
31fibrosarcoma10.0AKT1, MDM2
32lung benign neoplasm10.0MDM2, TP53
33retinoblastoma10.0TP53, MDM2, AKT1
34leiomyosarcoma10.0TP63, MDM2, TP53
35medulloblastoma10.0TP53, AKT1
36transitional cell carcinoma10.0TP63, TP53, MDM2
37non-small cell lung carcinoma10.0MDM2, TP63, TP53
38cervical cancer10.0TP63, TP53, MDM2
39sarcoma10.0TP53, TP63, MDM2
40malignant glioma10.0MDM2, TP53, AKT1
41ovarian cancer10.0TP53, MDM2, AKT1
42lung cancer10.0TP63, TP53, MDM2
43colon cancer10.0MDM2, TP53, AKT1
44burkitt's lymphoma10.0MDM2, AKT1, TP53
45hepatocellular carcinoma10.0AKT1, MDM2, TP53
46colorectal cancer10.0TP53, AKT1, MDM2
47neuroblastoma10.0AKT1, TP53
48tongue squamous cell carcinoma9.9TP63, MDM2, AKT1, TP53
49adenocarcinoma9.9TP63, MDM2, AKT1, TP53
50prostate cancer9.9MDM2, AKT1, TP53, TP63

Graphical network of the top 20 diseases related to Anal Squamous Cell Carcinoma:



Diseases related to anal squamous cell carcinoma

Symptoms for Anal Squamous Cell Carcinoma

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Drugs & Therapeutics for Anal Squamous Cell Carcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Anal Squamous Cell Carcinoma

Search NIH Clinical Center for Anal Squamous Cell Carcinoma

Genetic Tests for Anal Squamous Cell Carcinoma

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Anatomical Context for Anal Squamous Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Anal Squamous Cell Carcinoma:

33
T cells, Lymph node, Cervix

Animal Models for Anal Squamous Cell Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Anal Squamous Cell Carcinoma:

37 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6MDM2, AKT1, TP53, TP63
2MP:00053758.5DMD, TP53, AKT1
3MP:00107718.4TP63, TP53, AKT1, MDM2
4MP:00053708.4DMD, TP53, AKT1, MDM2
5MP:00053718.4DMD, TP63, TP53, MDM2
6MP:00053808.4MDM2, AKT1, TP53, TP63
7MP:00053678.3MDM2, TP53, TP63, DMD
8MP:00053818.2MDM2, TP53, TP63, DMD
9MP:00053888.2DMD, TP63, TP53, AKT1
10MP:00036318.2MDM2, AKT1, TP53, DMD
11MP:00053798.1DMD, TP63, TP53, AKT1
12MP:00053697.9MDM2, AKT1, TP53, TP63, DMD
13MP:00053907.9DMD, TP63, TP53, AKT1, MDM2
14MP:00028737.9DMD, TP63, TP53, AKT1, MDM2
15MP:00053897.9MDM2, AKT1, TP53, TP63, DMD
16MP:00053977.9MDM2, AKT1, TP53, DMD
17MP:00053857.9DMD, TP63, TP53, AKT1, MDM2
18MP:00053867.8DMD, TP63, TP53, AKT1, MDM2
19MP:00053877.8DMD, TP63, TP53, AKT1, MDM2
20MP:00053847.8MDM2, AKT1, TP53, TP63, DMD
21MP:00053787.8DMD, TP63, TP53, AKT1, MDM2
22MP:00107687.6DMD, TP63, TP53, AKT1, MDM2

Publications for Anal Squamous Cell Carcinoma

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52PubMed
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Articles related to Anal Squamous Cell Carcinoma:

(show all 46)
idTitleAuthorsYear
1
Aggressive strategy for the treatment of synchronous metastatic anal squamous cell carcinoma. (23958077)
2013
2
Outcome of salvage surgery for anal squamous cell carcinoma. (23522325)
2013
3
When rectal bleeding is serious: anal squamous cell carcinoma in two intravenous cyclophosphamide treated systemic lupus erythematosus patients with human papilloma virus infection. (23893826)
2013
4
A systematic review of anal squamous cell carcinoma in inflammatory bowel disease. (24050823)
2013
5
Systematic review of sentinel lymph node biopsy in anal squamous cell carcinoma. (23872032)
2013
6
Salvage Surgery for Residual Primary and Locally Recurrent Anal Squamous Cell Carcinoma After Chemoradiotherapy in HIV-positive Individuals. (24242676)
2013
7
Intensity-modulated radiotherapy vs. conventional radiotherapy in the treatment of anal squamous cell carcinoma: a propensity score analysis. (23692961)
2013
8
Cutaneous vulvar metastases in a patient with anal squamous cell carcinoma. (23617081)
2013
9
Development of cerebral metastasis after medical and surgical treatment of anal squamous cell carcinoma. (23091760)
2012
10
Early clinical outcomes of anal squamous cell carcinoma treated with concurrent chemoradiotherapy with 5-Fluorouracil plus mitomycin C in Japanese patients: experience at a single institution. (22717459)
2012
11
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients. (23033134)
2012
12
Current treatment of anal squamous cell carcinoma. (23116582)
2012
13
Advanced anal squamous cell carcinoma -- radiotherapy or surgery? (23116837)
2012
14
Metachronous splenic metastasis in an anal squamous cell carcinoma. (21563664)
2011
15
The prognostic significance of tumor human papillomavirus status for patients with anal squamous cell carcinoma treated with combined chemoradiotherapy. (21128253)
2011
16
The role of A^a8,fluoro-deoxy glucose combined position emission and computed tomography in the clinical management of anal squamous cell carcinoma. (20070338)
2011
17
Chemoradiation for anal squamous cell carcinoma: case report. (22018257)
2011
18
Concurrent cisplatin, continuous infusion fluorouracil and radiotherapy followed by tailored consolidation treatment in non metastatic anal squamous cell carcinoma. (21291546)
2011
19
Radiation therapy of recurrent anal squamous cell carcinoma in-situ: a case report. (20181236)
2010
20
Immunosuppressive disorders and risk of anal squamous cell carcinoma: a nationwide cohort study in Denmark, 1978-2005. (19960431)
2010
21
Current therapeutic strategies for anal squamous cell carcinoma in Japan. (19856049)
2009
22
Anal squamous cell carcinoma in the HIV-positive patient. (20436834)
2009
23
Evaluation by 18F-FDG-PET of patients with anal squamous cell carcinoma. (19330178)
2009
24
Invasive anal squamous-cell carcinoma in the HIV-positive patient: outcome in the era of highly active antiretroviral therapy. (18066626)
2008
25
Chemoradiotherapy with or without consolidation chemotherapy using cisplatin and 5-fluorouracil in anal squamous cell carcinoma: long-term results in 31 patients. (18194582)
2008
26
Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma. (17721920)
2007
27
Letter to the editor concerning "HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN)" by Varnai et al. (Int J Colorectal Dis 21:135-142, 2006). (16703315)
2007
28
Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. (17255774)
2007
29
Human papillomavirus (HPV), DNA aberrations and cell cycle progression in anal squamous cell carcinoma patients. (18214063)
2007
30
HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis. (15864603)
2006
31
Histological features of human papilloma virus 16 and its association with the development and progression of anal squamous cell carcinoma. (16998682)
2006
32
Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. (16740757)
2006
33
DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. (16166431)
2005
34
Angiogenesis in anal warts, anal intraepithelial neoplasia and anal squamous cell carcinoma. (12814415)
2003
35
Prognostic value of apoptosis-regulating protein expression in anal squamous cell carcinoma. (14695153)
2003
36
Outcome analysis of HIV-positive patients with anal squamous cell carcinoma. (11330577)
2001
37
Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma. (11598481)
2001
38
Anal squamous cell carcinoma in a patient with Peutz-Jeghers syndrome. (11281174)
2001
39
An alternative treatment of anal squamous cell carcinoma: combined radiotherapy and chemotherapy. (8441261)
1993
40
Nucleolar organiser regions (AgNORS) in anal intraepithelial neoplasia and invasive anal squamous cell carcinoma. (1430259)
1992
41
In situ hybridization analysis of human papillomavirus in anal squamous cell carcinoma. (2554279)
1989
42
Anal squamous cell carcinoma arising on radio-dermatitis cured with chemotherapy alone: case report. (3660479)
1987
43
Human papillomavirus type 16 DNA in anal squamous cell carcinoma. (2885526)
1987
44
Cisplatin plus 5-fluorouracil in the treatment of metastatic anal squamous cell carcinoma: a report of two cases. (3768879)
1986
45
Effectiveness of cisplatin in the treatment of anal squamous cell carcinoma. (4040426)
1985
46
CERVICAL CARCINOMA IN SITU AND ANAL SQUAMOUS-CELL CARCINOMA FOLLOWING RADIATION THERAPY FOR SQUAMOUS-CELL CARCINOMA OF CERVIX. (14069947)
1963

Variations for Anal Squamous Cell Carcinoma

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Expression for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anal Squamous Cell Carcinoma

Search GEO for disease gene expression data for Anal Squamous Cell Carcinoma.

Pathways for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
50PathCards, 5Cell Signaling Technology, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 53QIAGEN, 61Tocris Bioscience, 30KEGG, 54R&D Systems, 57SinoBiological, 12EMD Millipore, 51PharmGKB
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Pathways related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MDM2, AKT1
29.5MDM2, AKT1
39.5MDM2, TP53
49.5MDM2, TP53
59.5MDM2, TP53
69.5TP53, MDM2
79.5MDM2, TP53
8
Show member pathways
ATM Signaling Pathway38
9.5TP53, MDM2
99.5TP53, MDM2
10
Show member pathways
9.4AKT1, TP53
11
Show member pathways
9.4TP53, AKT1
129.4AKT1, TP53
13
Show member pathways
9.4AKT1, TP53
14
Show member pathways
9.4AKT1, TP53
15
Show member pathways
9.4TP53, AKT1
16
Show member pathways
9.4TP53, AKT1
179.4TP53, AKT1
18
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.0MDM2, AKT1, TP53
199.0MDM2, AKT1, TP53
209.0MDM2, AKT1, TP53
21
Show member pathways
9.0MDM2, AKT1, TP53
22
Show member pathways
9.0MDM2, AKT1, TP53
23
Show member pathways
9.0MDM2, AKT1, TP53
249.0TP53, AKT1, MDM2
259.0MDM2, AKT1, TP53
269.0TP53, AKT1, MDM2
27
Show member pathways
9.0MDM2, AKT1, TP53
28
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.0TP53, AKT1, MDM2
299.0MDM2, AKT1, TP53
309.0TP53, AKT1, MDM2
319.0TP53, AKT1, MDM2
32
Show member pathways
DNA damage Role of SUMO in p53 regulation60
9.0MDM2, AKT1, TP53
33
Show member pathways
p53 pathway38
9.0MDM2, AKT1, TP53
34
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.0TP53, AKT1, MDM2
35
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.0MDM2, AKT1, TP53
36
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.0TP53, AKT1, MDM2
37
Show member pathways
Signaling Pathways in Glioblastoma38
9.0MDM2, AKT1, TP53
389.0MDM2, AKT1, TP53
39
Show member pathways
9.0TP53, AKT1, MDM2
409.0MDM2, AKT1, TP53
41
Show member pathways
9.0MDM2, AKT1, TP53
42
Show member pathways
9.0TP53, AKT1, MDM2
439.0MDM2, AKT1, TP53
44
Show member pathways
Signal transduction PTEN pathway60
9.0MDM2, AKT1, TP53
459.0MDM2, AKT1, TP53
46
Show member pathways
8.9MDM2, TP53, TP63
47
Show member pathways
8.9MDM2, TP53, TP63
488.9MDM2, TP53, TP63
498.9TP63, TP53, MDM2
50
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.4MDM2, AKT1, TP53, TP63

Compounds for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
110-hydroxycamptothecin459.9TP53, MDM2
2bpde459.9MDM2, TP53
3chlorambucil45 1110.9MDM2, TP53
4aflatoxin b145 2410.9MDM2, TP53
52-chlorodeoxyadenosine459.8TP53, MDM2
6dutp459.8TP53, MDM2
7bcnu459.8TP53, AKT1
8methylmethanesulfonate459.8TP53, MDM2
9sodium arsenite459.8AKT1, TP53
10roscovitine459.8MDM2, TP53
11indole-3-carbinol459.8AKT1, TP53
12benzo(a)pyrene459.7MDM2, TP53
13fludarabine45 51 1111.7MDM2, TP53
14leptomycin b45 6110.7MDM2, TP53
15flavopiridol45 1110.7TP53, MDM2
16melphalan45 51 1111.6TP53, MDM2
17phosphorothioate459.6MDM2, DMD
18vinblastine45 51 1111.5MDM2, TP53
19carboplatin45 51 1111.4MDM2, AKT1, TP53
20lactacystin459.4MDM2, AKT1, TP53
21sp 60012545 6110.4MDM2, AKT1, TP53
22vincristine45 51 1111.4TP53, AKT1, MDM2
23adriamycin459.4MDM2, AKT1, TP53
24mg 13245 6110.4MDM2, AKT1, TP53
25curcumin459.4MDM2, AKT1, TP53
26arsenite45 2410.4MDM2, AKT1, TP53
27guanine45 24 1111.4MDM2, AKT1, TP53
28etoposide45 51 61 1112.4TP53, AKT1, MDM2
29paclitaxel45 51 1111.4TP53, AKT1, MDM2
30ly294002459.3MDM2, AKT1, TP53
31c2ceramide459.3AKT1, TP53
32actinomycin d459.3MDM2, AKT1, TP53
33noxa459.3TP63, TP53, MDM2
34mitomycin c459.3TP63, TP53, MDM2
35cycloheximide459.2TP53, AKT1, MDM2
36thymidine45 2410.2MDM2, TP53, TP63
37h2o2459.0MDM2, AKT1, TP53
38glycogen45 2410.0MDM2, AKT1, DMD
39hematoxylin459.0DMD, TP63
40progesterone45 29 61 24 1113.0MDM2, TP53, TP63
41proline459.0MDM2, TP53, DMD
42doxorubicin45 51 1110.8TP63, TP53, AKT1, MDM2
43paraffin458.8MDM2, AKT1, TP53, TP63
44cisplatin45 51 61 1111.8TP63, TP53, AKT1, MDM2
45vegf458.8TP63, TP53, AKT1, MDM2
46estrogen458.8MDM2, AKT1, TP53, TP63
47testosterone45 61 24 1111.6MDM2, AKT1, TP63
48serine458.5DMD, TP53, AKT1, MDM2
49tyrosine458.3MDM2, AKT1, TP63, DMD
50arginine458.0MDM2, AKT1, TP53, TP63, DMD

GO Terms for genes affiliated with Anal Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.5MDM2, TP53
2nuclear chromatinGO:0007909.3TP53, TP63
3chromatinGO:0007859.0TP53, TP63
4protein complexGO:0432348.8DMD, TP53, MDM2
5nucleoplasmGO:0056548.4TP63, TP53, AKT1, MDM2
6cytosolGO:0058297.7MDM2, AKT1, TP53, TP63, DMD
7nucleusGO:0056347.4DMD, TP63, TP53, AKT1, MDM2

Biological processes related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:0466779.8MDM2, TP53
2protein import into nucleus, translocationGO:0000609.8TP53, AKT1
3positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:0324369.8MDM2, AKT1
4positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:19007409.8AKT1, TP53
5mitotic G1 DNA damage checkpointGO:0315719.7TP63, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.7TP53, TP63
7response to X-rayGO:0101659.7TP53, TP63
8cell agingGO:0075699.7TP53, TP63
9negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.6AKT1, MDM2
10response to gamma radiationGO:0103329.6TP53, TP63
11intrinsic apoptotic signaling pathwayGO:0971939.6AKT1, TP53
12intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.6TP63, TP53
13cellular response to UVGO:0346449.6TP53, TP63
14DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.6MDM2, TP53
15neuron apoptotic processGO:0514029.6TP63, TP53
16phosphatidylinositol-mediated signalingGO:0480159.5MDM2, AKT1
17protein complex assemblyGO:0064619.4MDM2, TP53
18cellular protein localizationGO:0346139.4TP53, DMD
19cellular response to hypoxiaGO:0714569.3MDM2, AKT1, TP53
20negative regulation of transcription, DNA-templatedGO:0458929.1TP63, TP53, MDM2
21negative regulation of transcription from RNA polymerase II promoterGO:0001229.1TP63, TP53, MDM2
22Notch signaling pathwayGO:0072199.0TP53, TP63
23apoptotic processGO:0069158.9AKT1, TP53, TP63
24positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TP63, TP53, AKT1
25negative regulation of apoptotic processGO:0430668.7MDM2, AKT1, TP53, TP63

Molecular functions related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1damaged DNA bindingGO:0036849.2TP53, TP63
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.0TP53, TP63
3p53 bindingGO:0020399.0MDM2, TP53, TP63
4enzyme bindingGO:0198999.0TP53, AKT1, MDM2
5identical protein bindingGO:0428028.4MDM2, AKT1, TP53, TP63
6protein bindingGO:0055157.5TP63, TP53, AKT1, MDM2, DMD

Products for genes affiliated with Anal Squamous Cell Carcinoma

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  • Antibodies
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Sources for Anal Squamous Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet