MCID: ANL017
MIFTS: 42

Anal Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Aliases & Classifications for Anal Squamous Cell Carcinoma

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Anal Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Anal Squamous Cell Carcinoma 9 60
Epidermoid Anal Carcinoma 9
 
Carcinoma of Anal Margin 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:5525
SNOMED-CT55 255084004
NCIt38 C9161

Summaries for Anal Squamous Cell Carcinoma

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Disease Ontology:9 An anal carcinoma that arises near the squamocolumnar junction.

MalaCards based summary: Anal Squamous Cell Carcinoma, also known as epidermoid anal carcinoma, is related to papilloma and giant cell glioblastoma. An important gene associated with Anal Squamous Cell Carcinoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are PI3K / Akt Signaling and Androgen receptor signaling pathway. The compounds 10-hydroxycamptothecin and bpde have been mentioned in the context of this disorder. Affiliated tissues include t cells, lymph node and colon, and related mouse phenotypes are tumorigenesis and adipose tissue.

Related Diseases for Anal Squamous Cell Carcinoma

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Diseases related to Anal Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma30.9TP53, TP63
2giant cell glioblastoma10.4MDM2
3brain disease10.4AKT1
4systemic lupus erythematosus10.3
5peutz-jeghers syndrome10.3
6crohn's disease10.3
7cerebritis10.3
8cervicitis10.3
9dermatitis10.3
10lupus erythematosus10.3
11inflammatory bowel disease10.3
12li-fraumeni syndrome10.2MDM2, TP53
13liposarcoma10.2MDM2, TP53
14grade iii astrocytoma10.2MDM2, TP53
15oligodendroglioma10.2TP53, MDM2
16bladder cancer, somatic10.2TP53, MDM2
17esophageal cancer10.2TP53, MDM2
18pleomorphic adenoma10.2MDM2, TP63
19actinic keratosis10.2TP63, TP53
20oral cancer10.1TP53, MDM2
21nasopharyngeal carcinoma10.1MDM2, TP53
22endometrial cancer10.1TP63, TP53
23laryngeal squamous cell carcinoma10.1TP63, TP53
24thymoma10.1AKT1, TP63
25ataxia-telangiectasia10.1TP53, MDM2
26basal cell carcinoma10.1TP53, TP63
27multiple myeloma10.1AKT1, TP53
28glioblastoma multiforme10.1MDM2, TP53
29thyroid cancer10.1AKT1, TP53
30chronic granulomatous disease10.0AKT1, DMD
31fibrosarcoma10.0MDM2, AKT1
32lung benign neoplasm10.0MDM2, TP53
33retinoblastoma10.0MDM2, AKT1, TP53
34glioblastoma10.0TP53, AKT1, MDM2
35leiomyosarcoma10.0MDM2, TP53, TP63
36medulloblastoma10.0AKT1, TP53
37transitional cell carcinoma10.0TP63, TP53, MDM2
38cervical cancer, somatic10.0MDM2, TP53, TP63
39sarcoma9.9MDM2, TP53, TP63
40malignant glioma9.9TP53, AKT1, MDM2
41ovarian cancer, somatic9.9MDM2, AKT1, TP53
42lung cancer9.9MDM2, TP53, TP63
43burkitt lymphoma9.9MDM2, AKT1, TP53
44hepatocellular carcinoma9.9MDM2, AKT1, TP53
45colorectal cancer9.9TP53, AKT1, MDM2
46neuroblastoma9.9TP53, AKT1
47tongue squamous cell carcinoma9.7TP63, TP53, AKT1, MDM2
48adenocarcinoma9.7TP63, TP53, AKT1, MDM2
49prostate cancer9.7TP63, TP53, AKT1, MDM2
50breast cancer9.7TP63, TP53, AKT1, MDM2

Graphical network of the top 20 diseases related to Anal Squamous Cell Carcinoma:



Diseases related to anal squamous cell carcinoma

Symptoms for Anal Squamous Cell Carcinoma

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Drugs & Therapeutics for Anal Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Anal Squamous Cell Carcinoma

Search NIH Clinical Center for Anal Squamous Cell Carcinoma

Genetic Tests for Anal Squamous Cell Carcinoma

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Anatomical Context for Anal Squamous Cell Carcinoma

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MalaCards organs/tissues related to Anal Squamous Cell Carcinoma:

31
T cells, Lymph node, Colon, Cervix

Animal Models for Anal Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Anal Squamous Cell Carcinoma:

35 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6MDM2, AKT1, TP53, TP63
2MP:00053758.5DMD, TP53, AKT1
3MP:00107718.4TP63, TP53, AKT1, MDM2
4MP:00053708.4DMD, TP53, AKT1, MDM2
5MP:00053718.4DMD, TP63, TP53, MDM2
6MP:00053808.4MDM2, AKT1, TP53, TP63
7MP:00053678.3MDM2, TP53, TP63, DMD
8MP:00053818.2MDM2, TP53, TP63, DMD
9MP:00053888.2DMD, TP63, TP53, AKT1
10MP:00036318.2MDM2, AKT1, TP53, DMD
11MP:00053798.1DMD, TP63, TP53, AKT1
12MP:00053697.9MDM2, AKT1, TP53, TP63, DMD
13MP:00053907.9DMD, TP63, TP53, AKT1, MDM2
14MP:00028737.9DMD, TP63, TP53, AKT1, MDM2
15MP:00053897.9MDM2, AKT1, TP53, TP63, DMD
16MP:00053977.9MDM2, AKT1, TP53, DMD
17MP:00053857.9DMD, TP63, TP53, AKT1, MDM2
18MP:00053867.8DMD, TP63, TP53, AKT1, MDM2
19MP:00053877.8DMD, TP63, TP53, AKT1, MDM2
20MP:00053847.8MDM2, AKT1, TP53, TP63, DMD
21MP:00053787.8DMD, TP63, TP53, AKT1, MDM2
22MP:00107687.6DMD, TP63, TP53, AKT1, MDM2

Publications for Anal Squamous Cell Carcinoma

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Articles related to Anal Squamous Cell Carcinoma:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
High-sensitivity human papilloma virus genotyping reveals near universal positivity in anal squamous cell carcinoma: Different implications for vaccine prevention and prognosis. (25702585)
2015
2
Concomitant Chemoradiotherapy with Cisplatin Plus 5-Fluorouracil for Anal Squamous Cell Carcinoma. (25810165)
2015
3
Human papillomavirus DNA load and p16(INK4a) expression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy. (24839133)
2015
4
Anal squamous cell carcinoma in chronic severe perianal Crohn's disease. (25702309)
2015
5
Anal squamous cell carcinoma: an evolution in disease and management. (25278699)
2014
6
Prognostic value of human papillomavirus in anal squamous cell carcinoma. (25209946)
2014
7
Chemoradiation with capecitabine and mitomycin-C for stage I-III anal squamous cell carcinoma. (24885554)
2014
8
Atypical pelvic recurrence of anal squamous cell carcinoma: successful endoscopic ultrasound-guided fine-needle aspiration through the sigmoid colon. (24997718)
2014
9
Aggressive strategy for the treatment of synchronous metastatic anal squamous cell carcinoma. (23958077)
2013
10
Outcome of salvage surgery for anal squamous cell carcinoma. (23522325)
2013
11
When rectal bleeding is serious: anal squamous cell carcinoma in two intravenous cyclophosphamide treated systemic lupus erythematosus patients with human papilloma virus infection. (23893826)
2013
12
A systematic review of anal squamous cell carcinoma in inflammatory bowel disease. (24050823)
2013
13
Systematic review of sentinel lymph node biopsy in anal squamous cell carcinoma. (23872032)
2013
14
Salvage Surgery for Residual Primary and Locally Recurrent Anal Squamous Cell Carcinoma After Chemoradiotherapy in HIV-positive Individuals. (24242676)
2013
15
Intensity-modulated radiotherapy vs. conventional radiotherapy in the treatment of anal squamous cell carcinoma: a propensity score analysis. (23692961)
2013
16
Development of cerebral metastasis after medical and surgical treatment of anal squamous cell carcinoma. (23091760)
2012
17
Early clinical outcomes of anal squamous cell carcinoma treated with concurrent chemoradiotherapy with 5-Fluorouracil plus mitomycin C in Japanese patients: experience at a single institution. (22717459)
2012
18
Evaluation of Langerhans cells counts comparing HIV-positive and negative anal squamous cell-carcinoma patients. (23033134)
2012
19
Management of refractory metastatic anal squamous cell carcinoma following disease progression on traditional chemoradiation therapy. (25031942)
2012
20
Current treatment of anal squamous cell carcinoma. (23116582)
2012
21
Metachronous splenic metastasis in an anal squamous cell carcinoma. (21563664)
2011
22
The prognostic significance of tumor human papillomavirus status for patients with anal squamous cell carcinoma treated with combined chemoradiotherapy. (21128253)
2011
23
The role of A^a8,fluoro-deoxy glucose combined position emission and computed tomography in the clinical management of anal squamous cell carcinoma. (20070338)
2011
24
Chemoradiation for anal squamous cell carcinoma: case report. (22018257)
2011
25
Radiation therapy of recurrent anal squamous cell carcinoma in-situ: a case report. (20181236)
2010
26
Immunosuppressive disorders and risk of anal squamous cell carcinoma: a nationwide cohort study in Denmark, 1978-2005. (19960431)
2010
27
Current therapeutic strategies for anal squamous cell carcinoma in Japan. (19856049)
2009
28
Invasive anal squamous-cell carcinoma in the HIV-positive patient: outcome in the era of highly active antiretroviral therapy. (18066626)
2008
29
Chemoradiotherapy with or without consolidation chemotherapy using cisplatin and 5-fluorouracil in anal squamous cell carcinoma: long-term results in 31 patients. (18194582)
2008
30
Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma. (17721920)
2007
31
Letter to the editor concerning "HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN)" by Varnai et al. (Int J Colorectal Dis 21:135-142, 2006). (16703315)
2007
32
Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. (17255774)
2007
33
Human papillomavirus (HPV), DNA aberrations and cell cycle progression in anal squamous cell carcinoma patients. (18214063)
2007
34
Elevated anal squamous cell carcinoma risk associated with benign inflammatory anal lesions. (16299038)
2006
35
HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis. (15864603)
2006
36
Histological features of human papilloma virus 16 and its association with the development and progression of anal squamous cell carcinoma. (16998682)
2006
37
Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. (16740757)
2006
38
DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. (16166431)
2005
39
Angiogenesis in anal warts, anal intraepithelial neoplasia and anal squamous cell carcinoma. (12814415)
2003
40
Prognostic value of apoptosis-regulating protein expression in anal squamous cell carcinoma. (14695153)
2003
41
Outcome analysis of HIV-positive patients with anal squamous cell carcinoma. (11330577)
2001
42
Loss of heterozygosity and HIV infection in patients with anal squamous-cell carcinoma. (11598481)
2001
43
Anal squamous cell carcinoma in a patient with Peutz-Jeghers syndrome. (11281174)
2001
44
An alternative treatment of anal squamous cell carcinoma: combined radiotherapy and chemotherapy. (8441261)
1993
45
Nucleolar organiser regions (AgNORS) in anal intraepithelial neoplasia and invasive anal squamous cell carcinoma. (1430259)
1992
46
In situ hybridization analysis of human papillomavirus in anal squamous cell carcinoma. (2554279)
1989
47
Anal squamous cell carcinoma arising on radio-dermatitis cured with chemotherapy alone: case report. (3660479)
1987
48
Human papillomavirus type 16 DNA in anal squamous cell carcinoma. (2885526)
1987
49
Cisplatin plus 5-fluorouracil in the treatment of metastatic anal squamous cell carcinoma: a report of two cases. (3768879)
1986
50
CERVICAL CARCINOMA IN SITU AND ANAL SQUAMOUS-CELL CARCINOMA FOLLOWING RADIATION THERAPY FOR SQUAMOUS-CELL CARCINOMA OF CERVIX. (14069947)
1963

Variations for Anal Squamous Cell Carcinoma

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Expression for genes affiliated with Anal Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Anal Squamous Cell Carcinoma.

Pathways for genes affiliated with Anal Squamous Cell Carcinoma

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Pathways related to Anal Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MDM2, AKT1
29.5MDM2, AKT1
39.5MDM2, TP53
49.5MDM2, TP53
59.5MDM2, TP53
69.5TP53, MDM2
79.5MDM2, TP53
8
Show member pathways
ATM Signaling Pathway36
9.5TP53, MDM2
99.5TP53, MDM2
10
Show member pathways
9.4AKT1, TP53
11
Show member pathways
9.4TP53, AKT1
129.4AKT1, TP53
13
Show member pathways
9.4AKT1, TP53
14
Show member pathways
9.4AKT1, TP53
15
Show member pathways
9.4TP53, AKT1
16
Show member pathways
9.4TP53, AKT1
179.4TP53, AKT1
18
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
9.0MDM2, AKT1, TP53
199.0MDM2, AKT1, TP53
209.0MDM2, AKT1, TP53
21
Show member pathways
9.0MDM2, AKT1, TP53
22
Show member pathways
9.0MDM2, AKT1, TP53
23
Show member pathways
9.0MDM2, AKT1, TP53
249.0TP53, AKT1, MDM2
259.0MDM2, AKT1, TP53
269.0TP53, AKT1, MDM2
27
Show member pathways
9.0MDM2, AKT1, TP53
28
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.0TP53, AKT1, MDM2
299.0MDM2, AKT1, TP53
309.0TP53, AKT1, MDM2
319.0TP53, AKT1, MDM2
32
Show member pathways
DNA damage Role of SUMO in p53 regulation58
9.0MDM2, AKT1, TP53
33
Show member pathways
p53 pathway36
9.0MDM2, AKT1, TP53
34
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.0TP53, AKT1, MDM2
35
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.0MDM2, AKT1, TP53
36
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.0TP53, AKT1, MDM2
37
Show member pathways
Signaling Pathways in Glioblastoma36
9.0MDM2, AKT1, TP53
389.0MDM2, AKT1, TP53
39
Show member pathways
9.0TP53, AKT1, MDM2
409.0MDM2, AKT1, TP53
41
Show member pathways
9.0MDM2, AKT1, TP53
42
Show member pathways
9.0TP53, AKT1, MDM2
439.0MDM2, AKT1, TP53
44
Show member pathways
Signal transduction PTEN pathway58
9.0MDM2, AKT1, TP53
459.0MDM2, AKT1, TP53
46
Show member pathways
8.9MDM2, TP53, TP63
47
Show member pathways
8.9MDM2, TP53, TP63
488.9MDM2, TP53, TP63
498.9TP63, TP53, MDM2
50
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.4MDM2, AKT1, TP53, TP63

Compounds for genes affiliated with Anal Squamous Cell Carcinoma

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Compounds related to Anal Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
110-hydroxycamptothecin439.9TP53, MDM2
2bpde439.9MDM2, TP53
3chlorambucil43 1210.9MDM2, TP53
4aflatoxin b143 2410.9MDM2, TP53
52-chlorodeoxyadenosine439.8TP53, MDM2
6dutp439.8TP53, MDM2
7bcnu439.8TP53, AKT1
8methylmethanesulfonate439.8TP53, MDM2
9sodium arsenite439.8AKT1, TP53
10roscovitine439.8MDM2, TP53
11indole-3-carbinol439.8AKT1, TP53
12benzo(a)pyrene439.7MDM2, TP53
13fludarabine43 49 1211.7MDM2, TP53
14leptomycin b43 5910.7MDM2, TP53
15flavopiridol43 1210.7TP53, MDM2
16melphalan43 49 1211.6TP53, MDM2
17phosphorothioate439.6MDM2, DMD
18vinblastine43 49 1211.5MDM2, TP53
19carboplatin43 49 1211.4MDM2, AKT1, TP53
20lactacystin439.4MDM2, AKT1, TP53
21sp 60012543 5910.4MDM2, AKT1, TP53
22vincristine43 49 1211.4TP53, AKT1, MDM2
23adriamycin439.4MDM2, AKT1, TP53
24mg 13243 5910.4MDM2, AKT1, TP53
25curcumin439.4MDM2, AKT1, TP53
26arsenite43 2410.4MDM2, AKT1, TP53
27guanine43 24 1211.4MDM2, AKT1, TP53
28etoposide43 49 59 1212.4TP53, AKT1, MDM2
29paclitaxel43 49 1211.4TP53, AKT1, MDM2
30ly294002439.3MDM2, AKT1, TP53
31c2ceramide439.3AKT1, TP53
32actinomycin d439.3MDM2, AKT1, TP53
33noxa439.3TP63, TP53, MDM2
34mitomycin c439.3TP63, TP53, MDM2
35cycloheximide439.2TP53, AKT1, MDM2
36thymidine43 2410.2MDM2, TP53, TP63
37h2o2439.0MDM2, AKT1, TP53
38glycogen43 2410.0MDM2, AKT1, DMD
39hematoxylin439.0DMD, TP63
40progesterone43 28 59 24 1213.0MDM2, TP53, TP63
41proline439.0MDM2, TP53, DMD
42doxorubicin43 49 1210.8TP63, TP53, AKT1, MDM2
43paraffin438.8MDM2, AKT1, TP53, TP63
44cisplatin43 49 59 1211.8TP63, TP53, AKT1, MDM2
45vegf438.8TP63, TP53, AKT1, MDM2
46estrogen438.8MDM2, AKT1, TP53, TP63
47testosterone43 59 24 1211.6MDM2, AKT1, TP63
48serine438.5DMD, TP53, AKT1, MDM2
49tyrosine438.3MDM2, AKT1, TP63, DMD
50arginine438.0MDM2, AKT1, TP53, TP63, DMD

GO Terms for genes affiliated with Anal Squamous Cell Carcinoma

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Cellular components related to Anal Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166049.5MDM2, TP53
2nuclear chromatinGO:00007909.3TP53, TP63
3chromatinGO:00007859.0TP53, TP63
4protein complexGO:00432348.8DMD, TP53, MDM2
5nucleoplasmGO:00056548.4TP63, TP53, AKT1, MDM2
6cytosolGO:00058297.7MDM2, AKT1, TP53, TP63, DMD
7nucleusGO:00056347.4DMD, TP63, TP53, AKT1, MDM2

Biological processes related to Anal Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:00466779.8MDM2, TP53
2protein import into nucleus, translocationGO:00000609.8TP53, AKT1
3positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:00324369.8MDM2, AKT1
4positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:019007409.8AKT1, TP53
5mitotic G1 DNA damage checkpointGO:00315719.7TP63, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.7TP53, TP63
7response to X-rayGO:00101659.7TP53, TP63
8cell agingGO:00075699.7TP53, TP63
9negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.6AKT1, MDM2
10response to gamma radiationGO:00103329.6TP53, TP63
11intrinsic apoptotic signaling pathwayGO:00971939.6AKT1, TP53
12intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.6TP63, TP53
13cellular response to UVGO:00346449.6TP53, TP63
14DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.6MDM2, TP53
15neuron apoptotic processGO:00514029.6TP63, TP53
16phosphatidylinositol-mediated signalingGO:00480159.5MDM2, AKT1
17protein complex assemblyGO:00064619.4MDM2, TP53
18cellular protein localizationGO:00346139.4TP53, DMD
19cellular response to hypoxiaGO:00714569.3MDM2, AKT1, TP53
20negative regulation of transcription, DNA-templatedGO:00458929.1TP63, TP53, MDM2
21negative regulation of transcription from RNA polymerase II promoterGO:00001229.1TP63, TP53, MDM2
22Notch signaling pathwayGO:00072199.0TP53, TP63
23apoptotic processGO:00069158.9AKT1, TP53, TP63
24positive regulation of transcription from RNA polymerase II promoterGO:00459448.8TP63, TP53, AKT1
25negative regulation of apoptotic processGO:00430668.7MDM2, AKT1, TP53, TP63

Molecular functions related to Anal Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1damaged DNA bindingGO:00036849.2TP53, TP63
2RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:00010779.0TP53, TP63
3p53 bindingGO:00020399.0MDM2, TP53, TP63
4enzyme bindingGO:00198999.0TP53, AKT1, MDM2
5identical protein bindingGO:00428028.4MDM2, AKT1, TP53, TP63
6protein bindingGO:00055157.5TP63, TP53, AKT1, MDM2, DMD

Products for genes affiliated with Anal Squamous Cell Carcinoma

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Sources for Anal Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet