MCID: ANL017
MIFTS: 46

Anal Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Anal Squamous Cell Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An anal carcinoma that arises near the squamocolumnar junction.

MalaCards: Anal Squamous Cell Carcinoma, also known as epidermoid anal carcinoma, is related to squamous cell carcinoma and papilloma. An important gene associated with Anal Squamous Cell Carcinoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are PI3K / Akt Signaling and AKT phosphorylates targets in the cytosol. The compounds vincristine and guanine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and skin, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Anal Squamous Cell Carcinoma

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

anal squamous cell carcinoma 8 60
epidermoid anal carcinoma 8


External Ids:

Disease Ontology8 DOID:5525
SNOMED-CT56 255084004
NCIt39 C9161

Related Diseases for Anal Squamous Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anal Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.5TP53, AKT1, MDM2, TP63
2papilloma30.5TP63, TP53
3anal carcinoma in situ10.5
4in situ carcinoma10.5
5squamous cell papilloma10.4
6cerebritis10.2
7systemic lupus erythematosus10.2
8peutz-jeghers syndrome10.2
9cervical squamous cell carcinoma10.2
10cervicitis10.2
11dermatitis10.2
12inflammatory bowel disease10.2
13lupus erythematosus10.2
14giant cell glioblastoma10.0MDM2
15chondrosarcoma10.0MDM2
16anaplastic oligodendroglioma10.0MDM2
17benign meningioma10.0MDM2
18dermatofibrosarcoma10.0MDM2
19prion disease10.0AKT1
20malignant mesothelioma10.0TP63
21myoepithelioma10.0TP63
22ductal carcinoma in situ10.0TP53
23cholangiocarcinoma10.0TP53
24kidney cancer10.0TP53
25brain cancer10.0TP53
26lynch syndrome10.0TP53
27fibrosarcoma10.0AKT1, MDM2
28ischemia10.0DMD, AKT1
29chronic granulomatous disease10.0AKT1, DMD
30esophageal cancer10.0TP53
31thymoma10.0TP63, AKT1
32pleomorphic adenoma10.0MDM2, TP63
33ulcerative colitis10.0TP53
34osteosarcoma10.0MDM2, TP53
35ataxia telangiectasia10.0TP53, MDM2
36cervical cancer10.0TP53, MDM2
37li-fraumeni syndrome10.0TP53, MDM2
38breast cancer, invasive ductal10.0TP53, MDM2
39thyroid cancer10.0TP53, AKT1
40oral cancer10.0TP53, MDM2
41medulloblastoma10.0AKT1, TP53
42adenoma10.0TP63, TP53
43bladder carcinoma10.0TP53, MDM2
44endometrial carcinoma10.0TP63, TP53
45neuroblastoma10.0TP53, AKT1
46pancreatic cancer10.0TP53, AKT1
47actinic keratosis10.0TP53, TP63
48nasopharynx carcinoma10.0TP53, MDM2
49retinoblastoma10.0MDM2, AKT1, TP53
50anaplastic astrocytoma10.0MDM2, TP53

Graphical network of the top 20 diseases related to Anal Squamous Cell Carcinoma:



Diseases related to anal squamous cell carcinoma

Clinical Features for Anal Squamous Cell Carcinoma

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Drugs & Therapeutics for Anal Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Anal Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Anal Squamous Cell Carcinoma

Search NIH Clinical Center for Anal Squamous Cell Carcinoma

Search CenterWatch for Anal Squamous Cell Carcinoma

Genetic Tests for Anal Squamous Cell Carcinoma

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Anatomical Context for Anal Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Anal Squamous Cell Carcinoma:

32
Lymph node, T cells, Skin, Cervix

Animal Models for Anal Squamous Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anal Squamous Cell Carcinoma:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2DMD
2MP:00053699.0TP53, DMD, MDM2
3MP:00053798.6TP53, AKT1, DMD
4MP:00053708.4TP53, AKT1, DMD, MDM2
5MP:00053718.3TP53, TP63, DMD, MDM2
6MP:00020068.3MDM2, AKT1, TP63, TP53
7MP:00053818.2TP53, TP63, DMD, MDM2
8MP:00053888.2TP53, TP63, AKT1, DMD
9MP:00107718.0MDM2, AKT1, TP63, TP53
10MP:00053907.9MDM2, DMD, AKT1, TP63, TP53
11MP:00028737.8MDM2, DMD, AKT1, TP63, TP53
12MP:00053897.8TP53, TP63, AKT1, DMD, MDM2
13MP:00053857.8MDM2, DMD, AKT1, TP63, TP53
14MP:00053867.8TP53, TP63, AKT1, DMD, MDM2
15MP:00053877.8MDM2, DMD, AKT1, TP63, TP53
16MP:00053807.8MDM2, AKT1, TP63, TP53
17MP:00053847.7MDM2, DMD, AKT1, TP63, TP53
18MP:00053787.6MDM2, DMD, AKT1, TP63, TP53
19MP:00107687.5TP53, TP63, AKT1, DMD, MDM2

Publications for Anal Squamous Cell Carcinoma

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Sources:
50PubMed
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Articles related to Anal Squamous Cell Carcinoma:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Aggressive strategy for the treatment of synchronous metastatic anal squamous cell carcinoma. (23958077)
2013
2
Outcome of salvage surgery for anal squamous cell carcinoma. (23522325)
2013
3
Education and Imaging. Gastrointestinal: advanced untreated anal canal squamous cell carcinoma. (23692575)
2013
4
When rectal bleeding is serious: anal squamous cell carcinoma in two intravenous cyclophosphamide treated systemic lupus erythematosus patients with human papilloma virus infection. (23893826)
2013
5
A systematic review of anal squamous cell carcinoma in inflammatory bowel disease. (24050823)
2013
6
Systematic review of sentinel lymph node biopsy in anal squamous cell carcinoma. (23872032)
2013
7
Can radiobiological parameters derived from squamous cell carcinoma of the head and neck be used to predict local control in anal cancer treated with chemoradiation? (23239699)
2013
8
Clinicopathological analysis of basal cell carcinoma of the anal region and its distinction from basaloid squamous cell carcinoma. (23599161)
2013
9
Intensity-modulated radiotherapy vs. conventional radiotherapy in the treatment of anal squamous cell carcinoma: a propensity score analysis. (23692961)
2013
10
Cutaneous vulvar metastases in a patient with anal squamous cell carcinoma. (23617081)
2013
11
Development of cerebral metastasis after medical and surgical treatment of anal squamous cell carcinoma. (23091760)
2012
12
Early clinical outcomes of anal squamous cell carcinoma treated with concurrent chemoradiotherapy with 5-Fluorouracil plus mitomycin C in Japanese patients: experience at a single institution. (22717459)
2012
13
Twenty-year experience in the management of squamous cell anal canal carcinoma with interstitial brachytherapy. (21775274)
2011
14
Concurrent cisplatin, continuous infusion fluorouracil and radiotherapy followed by tailored consolidation treatment in non metastatic anal squamous cell carcinoma. (21291546)
2011
15
Radiation therapy of recurrent anal squamous cell carcinoma in-situ: a case report. (20181236)
2010
16
Immunosuppressive disorders and risk of anal squamous cell carcinoma: a nationwide cohort study in Denmark, 1978-2005. (19960431)
2010
17
Establishment and characterization of the human SaTM-1 anal canal squamous cell carcinoma cell line derived from lymph node metastasis. (19724886)
2009
18
K-ras status in squamous cell anal carcinoma (SCC): it's time for target-oriented treatment? (19727729)
2009
19
Current therapeutic strategies for anal squamous cell carcinoma in Japan. (19856049)
2009
20
Familial disseminated plaque type porokeratosis with multiple horns and squamous cell carcinoma involving anal skin. (19736460)
2009
21
Anal squamous cell carcinoma in the HIV-positive patient. (20436834)
2009
22
Evaluation by 18F-FDG-PET of patients with anal squamous cell carcinoma. (19330178)
2009
23
Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma. (18787619)
2008
24
Invasive anal squamous-cell carcinoma in the HIV-positive patient: outcome in the era of highly active antiretroviral therapy. (18066626)
2008
25
Chemoradiotherapy with or without consolidation chemotherapy using cisplatin and 5-fluorouracil in anal squamous cell carcinoma: long-term results in 31 patients. (18194582)
2008
26
Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma. (17721920)
2007
27
Evidence of clinical activity for cetuximab combined with irinotecan in a patient with refractory anal canal squamous-cell carcinoma: report of a case. (17252287)
2007
28
Squamous cell carcinoma arising from recurrent anal fistula. (17878704)
2007
29
Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. (17255774)
2007
30
Human papillomavirus (HPV), DNA aberrations and cell cycle progression in anal squamous cell carcinoma patients. (18214063)
2007
31
F-18 FDG PET/CT imaging of anal canal squamous cell carcinoma. (17314608)
2007
32
Treatment of squamous cell anal canal carcinoma (SCACC) with pulsed dose rate brachytherapy: a retrospective study. (16631268)
2006
33
HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis. (15864603)
2006
34
Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification. (16648870)
2006
35
Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. (16740757)
2006
36
DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. (16166431)
2005
37
Angiogenesis in anal warts, anal intraepithelial neoplasia and anal squamous cell carcinoma. (12814415)
2003
38
Prognostic value of apoptosis-regulating protein expression in anal squamous cell carcinoma. (14695153)
2003
39
Outcome analysis of HIV-positive patients with anal squamous cell carcinoma. (11330577)
2001
40
Anal squamous cell carcinoma in a patient with Peutz-Jeghers syndrome. (11281174)
2001
41
Anal canal squamous-cell carcinoma in situ, clearly demonstrated by indigo carmine dye spraying: report of a case. (10950017)
2000
42
Treatment of squamous cell anal canal carcinoma with pulsed dose rate brachytherapy. Feasibility study of a French cooperative group. (10435803)
1999
43
Amplification and expression of the cyclin D1 gene in anal and esophageal squamous cell carcinomas. (9042789)
1997
44
Treatment of invasive squamous cell carcinoma complicating anal Buschke-LAPwenstein tumor: a case history. (7544255)
1995
45
An alternative treatment of anal squamous cell carcinoma: combined radiotherapy and chemotherapy. (8441261)
1993
46
Nucleolar organiser regions (AgNORS) in anal intraepithelial neoplasia and invasive anal squamous cell carcinoma. (1430259)
1992
47
In situ hybridization analysis of human papillomavirus in anal squamous cell carcinoma. (2554279)
1989
48
Human papillomavirus type 16 DNA in anal squamous cell carcinoma. (2885526)
1987
49
Cisplatin plus 5-fluorouracil in the treatment of metastatic anal squamous cell carcinoma: a report of two cases. (3768879)
1986
50
CERVICAL CARCINOMA IN SITU AND ANAL SQUAMOUS-CELL CARCINOMA FOLLOWING RADIATION THERAPY FOR SQUAMOUS-CELL CARCINOMA OF CERVIX. (14069947)
1963

Genetic Variations for Anal Squamous Cell Carcinoma

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Expression for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anal Squamous Cell Carcinoma

Search GEO for disease gene expression data for Anal Squamous Cell Carcinoma.

Pathways for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
4Cell Signaling Technology, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems, 55SinoBiological, 59Tocris Bioscience, 49PharmGKB
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Pathways related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MDM2, AKT1
29.5MDM2, AKT1
39.5MDM2, AKT1
49.2TP53, MDM2
59.2TP53, MDM2
69.2MDM2, TP53
79.2TP53, MDM2
8
Transcription P53 signaling pathway
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9.2MDM2, TP53
99.1AKT1, TP53
10
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
Hide members
9.1TP53, AKT1
119.1AKT1, TP53
12
Hide members
9.1TP53, AKT1
13
Hide members
9.1AKT1, TP53
149.1TP53, AKT1
15
Hide members
9.0TP53, TP63
16
Hide members
8.7MDM2, AKT1, TP53
178.7TP53, MDM2, AKT1
188.7AKT1, TP53, MDM2
198.7TP53, AKT1, MDM2
208.7TP53, MDM2, AKT1
218.7MDM2, TP53, AKT1
228.7TP53, AKT1, MDM2
238.7AKT1, TP53, MDM2
24
Hide members
8.7TP53, AKT1, MDM2
258.7TP53, AKT1, MDM2
268.7TP53, AKT1, MDM2
278.7AKT1, MDM2, TP53
288.7MDM2, AKT1, TP53
29
Hide members
8.7AKT1, TP53, MDM2
308.7MDM2, TP53, AKT1
31
Hide members
8.7TP53, AKT1, MDM2
32
Hide members
8.7TP53, AKT1, MDM2
33
Hide members
8.7AKT1, MDM2, TP53
34
Hide members
8.7AKT1, TP53, MDM2
358.7TP53, MDM2, AKT1
36
Hide members
8.7TP53, AKT1, MDM2
37
Hide members
8.7MDM2, AKT1, TP53
38
Hide members
8.7MDM2, AKT1, TP53
398.6TP53, MDM2, TP63
408.6TP53, TP63, MDM2
418.6TP63, TP53, MDM2

Compounds for genes affiliated with Anal Squamous Cell Carcinoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.4AKT1
2guanine44 11 2412.4AKT1
3phosphorothioate449.9DMD, MDM2
410-hydroxycamptothecin449.6TP53, MDM2
5bpde449.6TP53, MDM2
6chlorambucil44 1110.6TP53, MDM2
7aflatoxin b144 2410.6TP53, MDM2
82-chlorodeoxyadenosine449.6TP53, MDM2
9dutp449.5TP53, MDM2
10methylmethanesulfonate449.5TP53, MDM2
11bcnu449.5TP53, AKT1
12fludarabine44 1110.5MDM2, TP53
13hematoxylin449.5TP63, DMD
14roscovitine449.5TP53, MDM2
15sodium arsenite449.5TP53, AKT1
16benzo(a)pyrene449.5MDM2, TP53
17indole-3-carbinol449.5AKT1, TP53
18leptomycin b44 5910.5TP53, MDM2
19flavopiridol44 1110.4MDM2, TP53
20melphalan44 1110.4TP53, MDM2
21glycogen44 2410.3MDM2, DMD, AKT1
22c2ceramide449.3AKT1, TP53
23vinblastine44 49 1111.3TP53, MDM2
24carboplatin44 49 1111.2TP53, MDM2
25lactacystin449.1TP53, AKT1, MDM2
26sp 60012544 5910.1TP53, AKT1, MDM2
27adriamycin449.1MDM2, AKT1, TP53
28mg 13244 5910.1TP53, AKT1, MDM2
29irinotecan44 49 1111.1TP53, MDM2
30curcumin449.1MDM2, AKT1, TP53
31arsenite44 2410.1TP53, AKT1, MDM2
32etoposide44 49 59 1112.1MDM2, AKT1, TP53
33paclitaxel44 49 1111.1MDM2, AKT1, TP53
34ly294002449.0TP53, AKT1, MDM2
35actinomycin d449.0TP53, AKT1, MDM2
36noxa449.0MDM2, TP63, TP53
37mitomycin c449.0MDM2, TP63, TP53
38proline449.0TP53, DMD, MDM2
39thymidine44 249.9TP53, TP63, MDM2
40cycloheximide448.9TP53, AKT1, MDM2
41progesterone44 59 28 11 2412.6MDM2, TP63, TP53
42doxorubicin44 49 1110.5TP53, TP63, AKT1, MDM2
43paraffin448.5MDM2, AKT1, TP63, TP53
44cisplatin44 49 59 1111.5TP53, TP63, AKT1, MDM2
45vegf448.5TP53, TP63, AKT1, MDM2
46tyrosine448.5TP63, AKT1, DMD, MDM2
47estrogen448.5TP53, TP63, AKT1, MDM2
48serine448.4TP53, AKT1, DMD, MDM2
49h2o2448.4TP53, AKT1, MDM2
50arginine448.0TP53, TP63, AKT1, DMD, MDM2

GO Terms for genes affiliated with Anal Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.0TP63, TP53
2nuclear bodyGO:0166048.9TP53, MDM2
3protein complexGO:0432348.7MDM2, DMD, TP53
4nucleoplasmGO:0056548.0MDM2, AKT1, TP63, TP53
5cytosolGO:0058297.5MDM2, DMD, AKT1, TP63, TP53

Biological processes related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:0324369.6AKT1, MDM2
2response to antibioticGO:0466779.4TP53, MDM2
3protein import into nucleus, translocationGO:0000609.4TP53, AKT1
4negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.4AKT1, MDM2
5mitotic G1 DNA damage checkpointGO:0315719.3TP63, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.3TP53, TP63
7response to X-rayGO:0101659.3TP53, TP63
8intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.3TP63, TP53
9cell agingGO:0075699.3TP63, TP53
10response to gamma radiationGO:0103329.3TP63, TP53
11cellular protein localizationGO:0346139.2DMD, TP53
12neuron apoptotic processGO:0514029.2TP63, TP53
13cellular response to UVGO:0346449.2TP53, TP63
14intrinsic apoptotic signaling pathwayGO:0971939.1TP53, AKT1
15cellular response to hypoxiaGO:0714569.0MDM2, AKT1, TP53
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069778.9MDM2, TP53
17negative regulation of transcription, DNA-dependentGO:0458928.6TP63, TP53, MDM2
18negative regulation of transcription from RNA polymerase II promoterGO:0001228.6MDM2, TP63, TP53
19negative regulation of apoptotic processGO:0430668.4AKT1, TP53, MDM2, TP63

Molecular functions related to Anal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.0TP63, TP53
2damaged DNA bindingGO:0036848.7TP63, TP53
3p53 bindingGO:0020398.6TP53, TP63, MDM2
4enzyme bindingGO:0198998.6MDM2, AKT1, TP53
5identical protein bindingGO:0428028.1MDM2, AKT1, TP63, TP53

Products for genes affiliated with Anal Squamous Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anal Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet