MCID: ANP005
MIFTS: 44

Anaplastic Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Anaplastic Astrocytoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Anaplastic astrocytoma is a WHO grade III type of astrocytoma, which is a type of cancer of the brain.... more...

MalaCards: Anaplastic Astrocytoma, also known as high-grade astrocytoma, is related to astrocytoma and glioblastoma multiforme. An important gene associated with Anaplastic Astrocytoma is MMP12 (matrix metallopeptidase 12 (macrophage elastase)). The compounds streptozotocin and matrigel have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are homeostasis/metabolism and cellular.

Aliases & Classifications for Anaplastic Astrocytoma

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44NIH Rare Diseases, 46Novoseek, 50Orphanet, 63UMLS, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
anaplastic astrocytoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

anaplastic astrocytoma 44 46 50 63
high-grade astrocytoma 44
malignant astrocytoma 44


External Ids:

SNOMED-CT via Orphanet60 55353007
UMLS via Orphanet64 C0334579

Related Diseases for Anaplastic Astrocytoma

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18GeneCards, 19GeneDecks
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Diseases related to Anaplastic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.6CDKN2B, DMBT1, APOD, TUBG1, NES, FGFR4
2glioblastoma multiforme31.1CDKN2B, NES, ADM, DMBT1
3pilocytic astrocytoma30.7APOD, NES
4meningioma30.5MMP12, CDKN2B, S100A5
5medulloblastoma30.5DMBT1, NES, CDKN2B
6malignant glioma30.4CDKN2B, NES, DMBT1
7oligodendroglioma30.1APOD, DMBT1, CDKN2B
8melanoma30.0DMBT1, FGFR4, MMP12, CDKN2B, NES
9cerebritis10.3
10neurofibromatosis10.3
11myelodysplastic syndromes10.3
12oligoastrocytoma10.3
13phaeohyphomycosis10.2
14turcot syndrome10.2
15craniopharyngioma10.2
16newcastle disease10.1
17autoimmune lymphoproliferative syndrome10.1
18transcobalamin ii deficiency10.1
19acromegaly10.1
20gliosarcoma10.1
21idiopathic cd4-positive t-lymphocytopenia10.1
22ollier disease10.1
23arteriovenous malformation10.1
24pleomorphic xanthoastrocytoma10.1
25central neurocytoma10.1
26colorectal cancer10.1
27hemangioblastoma10.1
28histiocytosis10.1
29leukemia10.1
30lymphoblastic leukemia10.1
31mediastinitis10.1
32renal cell carcinoma10.1
33seminoma10.1
34anaplastic oligoastrocytoma10.1
35anaplastic oligodendroglioma10.1
36germinoma10.1
37glomus jugulare tumors10.1
38t-lymphocytopenia10.1
39mental retardation10.1
40endotheliitis10.1
41ganglioglioma10.1APOD
42malignant peripheral nerve sheath tumor10.0NES, APOD
43adult respiratory distress syndrome10.0
44tuberous sclerosis10.0
45muir-torre syndrome10.0
46central nervous system cancer10.0
47colon cancer10.0
48nervous system cancer10.0
49neuroblastoma10.0
50primitive neuroectodermal tumor10.0

Graphical network of the top 20 diseases related to Anaplastic Astrocytoma:



Diseases related to anaplastic astrocytoma

Symptoms for Anaplastic Astrocytoma

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Drugs & Therapeutics for Anaplastic Astrocytoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Anaplastic Astrocytoma

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Anatomical Context for Anaplastic Astrocytoma

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34MalaCards
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MalaCards organs/tissues related to Anaplastic Astrocytoma:

34
Brain, Spinal cord, Bone, Testes, Bone marrow, Endothelial, Pineal, Cortex, Cerebellum

Animal Models for Anaplastic Astrocytoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Anaplastic Astrocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1FGFR4, CDKN2B, ADM, MMP12, APOD, DMBT1
2MP:00053847.4DMBT1, TUBG1, NES, ADM, CDKN2B, FGFR4
3MP:00107687.3FGFR4, DMBT1, TUBG1, APOD, NES, ADM

Publications for Anaplastic Astrocytoma

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53PubMed
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Articles related to Anaplastic Astrocytoma:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
The genetic landscape of anaplastic astrocytoma. (24140581)
2013
2
An infant with prenatally diagnosed congenital anaplastic astrocytoma who remains disease-free after proton therapy. (24015049)
2013
3
Skeletal spread of an anaplastic astrocytoma (WHO grade III) and preservation of histopathological properties within metastases. (22704562)
2013
4
A case of adult onset medulloblastoma during maintenance chemotherapy for anaplastic astrocytoma one year after radiotherapy. (24101275)
2013
5
Cerebellar anaplastic astrocytoma in an adult with neurofibromatosis type 1: case report and review of literature. (23670807)
2013
6
Heterogeneous nuclear ribonucleoproteins and their interactors are a major class of deregulated proteins in anaplastic astrocytoma: a grade III malignant glioma. (23741984)
2013
7
The SDF-1 3'A genetic variation is correlated with elevated intra-tumor tissue and circulating concentration of CXCL12 in glial tumors: a study on Iranian anaplastic astrocytoma and glioblastoma multiforme patients. (23335032)
2013
8
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
9
Five-year follow-up results for patients diagnosed with anaplastic astrocytoma and effectiveness of concomitant therapy with temozolomide for recurrent anaplastic astrocytoma. (23559985)
2012
10
Analysis of NADP+-dependent isocitrate dehydrogenase-1/2 gene mutations in pediatric brain tumors: report of a secondary anaplastic astrocytoma carrying the IDH1 mutation. (22821382)
2012
11
A common 8q (MYC) amplification detected in a multifocal anaplastic astrocytoma by SNP array karyotyping. (22720694)
2012
12
Intracranial metastasis of spinal intramedullary anaplastic astrocytoma. (22347337)
2011
13
Anaplastic astrocytoma with angiocentric ependymal differentiation. (21062363)
2011
14
Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome (ALPS). (20846185)
2011
15
Infiltrating growing pattern xenografts induced by glioblastoma and anaplastic astrocytoma derived tumor stem cells. (21141095)
2010
16
Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation. (20658636)
2010
17
Overexpression of c-erbB2 is a negative prognostic factor in anaplastic astrocytomas. (20331873)
2010
18
Anaplastic astrocytoma post radiotherapy of pineal germinoma. (19722057)
2009
19
Corneal verticillata after dual anti-epidermal growth factor receptor and anti-vascular endothelial growth factor receptor 2 therapy (vandetanib) for anaplastic astrocytoma. (19512898)
2009
20
Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)
2008
21
Congenital diffuse anaplastic astrocytoma with ependymal and leptomeningeal spread: case report. (17443288)
2007
22
Prognostic factors for anaplastic astrocytomas. (17001519)
2007
23
Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma. Case report. (17639893)
2007
24
Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma. (16570196)
2006
25
Anaplastic astrocytoma presenting as reversible posterior leukoencephalopathy syndrome. (17122727)
2006
26
Primary glioblastomas and anaplastic astrocytoma in a glioma family. (16678736)
2006
27
Patient with resected anaplastic astrocytoma and an image suggestive of relapse. (17169765)
2006
28
Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma. (15671553)
2005
29
Anaplastic astrocytoma: diagnosis, prognosis, and management. (15497115)
2004
30
Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes. (14965379)
2004
31
Cytodiagnosis of anaplastic astrocytoma with metastasis to the cerebrospinal fluid in a neonate--a case report. (14571028)
2003
32
Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood. (14595708)
2003
33
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (11995970)
2001
34
Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. (11431323)
2001
35
Therapy-related myelodysplastic syndrome (t-MDS) in a patient with anaplastic astrocytoma: successful treatment with allogeneic bone marrow transplant. (11678432)
2001
36
Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy. (10730637)
2000
37
Anaplastic astrocytoma invading the optic chiasm through the optic pathway. (11014557)
2000
38
Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: A retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy. (10550132)
1999
39
Secondary supratentorial anaplastic astrocytoma following treatment of medulloblastoma. (10476368)
1999
40
Iatrogenic seeding of anaplastic astrocytoma following stereotactic biopsy. (9524102)
1998
41
Response of recurrent glioblastoma and anaplastic astrocytoma to dibromodulcitol, BCNU and procarbazine--a phase-II study. (9524094)
1998
42
Rapid resolution following chemotherapy of Broca's dysphasia due to recurrent anaplastic astrocytoma. (7917094)
1994
43
Congenital anaplastic astrocytoma. (2294178)
1990
44
Anaplastic astrocytoma and glioblastoma: pion irradiation with the dynamic conformation technique at the Swiss Institute for Nuclear Research (SIN). (2108474)
1990
45
Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma. (2542195)
1989
46
Anaplastic astrocytoma associated with human growth hormone administration. (3655821)
1987
47
Anaplastic astrocytoma mimicking metastatic carcinoma. (3532839)
1986
48
Anaplastic astrocytoma of the adult cerebrum. Prognostic value of histologic features. (3967200)
1985
49
Multiple primary intracranial tumors of different cell types: association of anaplastic astrocytoma and acoustic neurinoma--with review of the literature. (7179095)
1982
50
Anaplastic astrocytoma following radiation for a glomus jugular tumor. (222421)
1979

Variations for Anaplastic Astrocytoma

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Expression for genes affiliated with Anaplastic Astrocytoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Astrocytoma

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Pathways for genes affiliated with Anaplastic Astrocytoma

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Compounds for genes affiliated with Anaplastic Astrocytoma

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46Novoseek, 25HMDB
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Compounds related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1streptozotocin469.7ADM, NES
2matrigel469.4ADM, MMP12, NES
3paraffin469.2APOD, NES, ADM, FGFR4
4vegf469.1NES, MMP12, ADM, FGFR4
5estrogen468.8APOD, NES, ADM, CDKN2B
6retinoic acid46 259.6CDKN2B, ADM, NES, APOD
7lipid468.6ADM, MMP12, NES, APOD, TUBG1
8tyrosine468.1FGFR4, CDKN2B, ADM, MMP12, NES, TUBG1

GO Terms for genes affiliated with Anaplastic Astrocytoma

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17Gene Ontology
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Cellular components related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6FGFR4, ADM, MMP12, APOD, DMBT1
2cytoplasmGO:0057376.9FGFR4, DMBT1, TUBG1, NES, ADM, S100A3

Biological processes related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of epithelial cell differentiationGO:0308589.4CDKN2B, DMBT1
2G2/M transition of mitotic cell cycleGO:0000869.0CDKN2B, NES, TUBG1
3agingGO:0075689.0CDKN2B, ADM, APOD

Products for genes affiliated with Anaplastic Astrocytoma

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Sources for Anaplastic Astrocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet