MCID: ANP005
MIFTS: 35

Anaplastic Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Anaplastic Astrocytoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Anaplastic astrocytoma is a WHO grade III type of astrocytoma. more...

MalaCards: Anaplastic Astrocytoma, also known as high-grade astrocytoma, is related to astrocytoma and glioblastoma multiforme. An important gene associated with Anaplastic Astrocytoma is MMP12 (matrix metallopeptidase 12 (macrophage elastase)), and among its related pathways are Cell cycle and Cyclins and Cell Cycle Regulation. The compounds paraffin and progesterone have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Anaplastic Astrocytoma

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
anaplastic astrocytoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

anaplastic astrocytoma 42 44 48 60
high-grade astrocytoma 42
malignant astrocytoma 42


External Ids:

SNOMED-CT via Orphanet57 55353007

Related Diseases for Anaplastic Astrocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Anaplastic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.8LGALS3, FSCN1, OLIG2, OLIG1, FGFR4, CDK4
2glioblastoma multiforme31.2NES, CDKN2B, CDK4, IL13RA1, ADM
3medulloblastoma30.5CDK4, CDKN2B, NES, CCND2
4meningioma30.4S100A5, S100A6, CDKN2B, MMP12, TERF1
5malignant glioma30.4CCND2, NES, CDKN2B, CDK4, IL13RA1, OLIG2
6oligodendroglioma30.1OLIG2, OLIG1, CDKN2B
7brain cancer30.1NES, CDKN2B, CDK4, IL13RA1, OLIG1, OLIG2
8leukemia30.1CCND2, NES, CDKN2B, CDK4, FGFR4, OLIG2
9melanoma30.1S100A6, NES, CDKN2B, CDK4, MCM3, FGFR4
10colorectal cancer30.1CDK4, FGFR4, FSCN1, LGALS3
11colon cancer29.9CCND2, CDKN2B, CDK4, FGFR4, FSCN1, LGALS3
12spinal cord astrocytoma10.4
13cerebritis10.3
14cerebellar astrocytoma10.3
15neurofibromatosis10.2
16phaeohyphomycosis10.1
17craniopharyngioma10.1
18autoimmune lymphoproliferative syndrome10.1
19newcastle disease10.1
20arteriovenous malformation10.1
21transcobalamin ii deficiency10.1
22juvenile pilocytic astrocytoma10.1
23fibrillary astrocytoma10.1
24acromegaly10.1
25malignant histiocytosis10.1
26adult syndrome10.1
27central neurocytoma10.1
28adult medulloblastoma10.1
29pleomorphic xanthoastrocytoma10.1
30juvenile astrocytoma10.1
31gliosarcoma10.1
32brain glioblastoma multiforme10.1
33acute leukemia10.1
34idiopathic cd4-positive t-lymphocytopenia10.1
35ollier disease10.1
36brain disease10.1
37cerebellar disease10.1
38childhood pilocytic astrocytoma10.1
39glomus tumor10.1
40hemangioblastoma10.1
41histiocytosis10.1
42lymphoblastic leukemia10.1
43mediastinitis10.1
44optic nerve astrocytoma10.1
45renal cell carcinoma10.1
46seminoma10.1
47laryngeal squamous cell carcinoma10.0CDKN2B
48pilocytic astrocytoma10.0LGALS3, OLIG2, CDK4, NES, APOD
49cholesteatoma10.0LGALS3, S100A6
50anaplastic oligodendroglioma10.0CDKN2B, CDK4, OLIG1, OLIG2, LGALS3

Graphical network of the top 20 diseases related to Anaplastic Astrocytoma:



Diseases related to anaplastic astrocytoma

Clinical Features for Anaplastic Astrocytoma

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Drugs & Therapeutics for Anaplastic Astrocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Anaplastic Astrocytoma

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Anatomical Context for Anaplastic Astrocytoma

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Animal Models for Anaplastic Astrocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anaplastic Astrocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.3FGFR4, IL13RA1, OLIG2, LGALS3, FOXM1
2MP:000200610.3FOXM1, CDKN2B, CDK4, MCM3, FGFR4, OLIG2
3MP:001076810.1ADM, TUBG1, CCND2, APOD, FOXM1, NES
4MP:000538410.1TUBG1, CCND2, FOXM1, NES, CDKN2B, CDK4
5MP:000538710.1CCND2, FOXM1, CDKN2B, CDK4, IL13RA1, MMP12
6MP:00053769.9CDKN2B, FOXM1, APOD, CCND2, CDK4, FGFR4

Publications for Anaplastic Astrocytoma

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Genetic Variations for Anaplastic Astrocytoma

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Expression for genes affiliated with Anaplastic Astrocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Astrocytoma

Search GEO for disease gene expression data for Anaplastic Astrocytoma.

Pathways for genes affiliated with Anaplastic Astrocytoma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 4Cell Signaling Technology
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Compounds for genes affiliated with Anaplastic Astrocytoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1paraffin4410.5S100A6, APOD, NES, CDK4, FGFR4, FSCN1
2progesterone44 59 28 11 2414.5CCND2, S100A6, APOD, NES, CDK4, LGALS3
3vegf4410.5NES, CDK4, FGFR4, IL13RA1, MMP12, LGALS3
4phosphatidylinositol4410.4CCND2, CDK4, FGFR4, MMP12, LGALS3, ADM
5oligonucleotide4410.4CCND2, S100A6, APOD, FOXM1, CDK4, MMP12
6sucrose44 11 2412.4TUBG1, CCND2, CDK4, LGALS3
7tyrosine4410.4TUBG1, CCND2, NES, CDKN2B, CDK4, FGFR4
8retinoic acid44 2411.4ADM, CCND2, S100A6, APOD, FOXM1, NES
9steroid4410.3ADM, CDK4, FOXM1, S100A6
10nitric oxide44 11 2412.3NES, CDK4, IL13RA1, MMP12, LGALS3, ADM
11matrigel4410.3NES, MMP12, LGALS3, ADM
1212-o-tetradecanoylphorbol 13-acetate4410.0FOXM1, CDK4, FSCN1, ADM

GO Terms for genes affiliated with Anaplastic Astrocytoma

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16Gene Ontology
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Cellular components related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.1S100A6, S100A3, FOXM1, NES, CDKN2B, FGFR4
2cyclin-dependent protein kinase holoenzyme complexGO:00030710.1CCND2, CDK4
3nucleusGO:00563410.0LGALS3, CCND2, S100A5, S100A6, FOXM1, CDKN2B

Biological processes related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:04866310.4OLIG2, OLIG1
2G2/M transition of mitotic cell cycleGO:00008610.0TERF1, CDKN2B, NES, FOXM1, TUBG1

Molecular functions related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.0ADM, CCND2, S100A6, APOD, FOXM1, CDKN2B

Products for genes affiliated with Anaplastic Astrocytoma

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Sources for Anaplastic Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet