Anaplastic Astrocytoma malady

Wikipedia: Anaplastic astrocytoma is a WHO grade 3 type of astrocytoma.⁴⁴ more...

MalaCards: Anaplastic Astrocytoma, also known as high-grade astrocytoma, is related to glioblastoma and oligodendroglioma. An important gene associated with Anaplastic Astrocytoma is OLIG1 (oligodendrocyte transcription factor 1), and among its related pathways are Signal transduction_PTEN pathway and DNA damage ATM/ATR regulation of G1/S checkpoint. The compounds egcg and glucose have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and endothelial, and related mouse phenotypes are respiratory system and craniofacial.

anaplastic astrocytoma 30 8 32 43 high-grade astrocytoma 30

malignant astrocytoma 30

Diseases related to anaplastic astrocytoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 639)

id	Related Disease	Score	Top Affiliating Genes
1	glioblastoma	31.0	RB1, BSG, VEGFA, LGALS1, CDKN2B, CDKN2A
2	oligodendroglioma	30.0	CDKN2B, CDKN2A, MGMT, TP73, PTEN, OLIG1
3	central neurocytoma	29.7	PCNA, S100B, MKI67, TP53, OLIG2, GFAP
4	anaplastic oligodendroglioma	29.3	RB1, LGALS3, CDKN2B, CDKN2A, CDK4, MGMT
5	dna topoisomerase i	28.2	BLZF1, CDKN2A, CDK4, MKI67, ERBB2, TP53
6	pilocytic astrocytoma	27.9	VEGFA, RAB3IP, LGALS1, LGALS2, LGALS3, LGALS8
7	neuroectodermal tumors	26.6	RB1, S100A1, S100B, CDKN2A, CDK4, MDM2
8	tuberous sclerosis	25.1	PCNA, VEGFA, S100B, MMP2, IGF1, TP53
9	medulloblastoma	23.9	PCNA, RB1, BLZF1, S100A4, S100A6, S100B
10	cerebritis	20.6	PCNA, VEGFA, BLZF1, LGALS2, S100A6, S100B
11	astrocytoma	20.3	PCNA, RB1, BSG, VEGFA, BLZF1, LGALS1
12	colorectal cancer	17.2	PCNA, RB1, BSG, VEGFA, BLZF1, LGALS1
13	neuroblastoma	16.0	PCNA, RB1, BSG, VEGFA, BLZF1, LGALS1
14	familial melanoma	13.8	CDKN2A, CDK4, MGMT, MDM2
15	inverted papilloma	13.8	PCNA, FSCN1, MKI67
16	choroid plexus carcinoma	13.8	TP53, PDGFRA, PDGFRB, ADM
17	gastric cardia adenocarcinoma	13.7	MMP12, MMP2, CTSB, THBS1
18	atypical lipomatous tumor	13.7	CDKN2A, CDK4, MDM2
19	adult astrocytic tumour	13.7	LGALS3, CDKN2A, MDM2, TP53
20	proliferative vitreoretinopathy	13.7	TNC, GFAP, TIMP2, THBS1, ADM
21	pulmonary vein stenosis	13.7	MKI67, PDGFRA, TYMP
22	adult medulloblastoma	13.7	MDM2, TP53, TNFSF10
23	primary malignant lymphoma	13.7	CDKN2B, CDKN2A, TP53
24	acute lymphoblastic leukemia, childhood	13.7	CDKN2B, CDKN2A, MDM2
25	eccrine porocarcinoma	13.7	CDKN2A, TP53, TP73
26	thyroid cancer, follicular	13.7	LGALS3, FLT1, PTEN, PLAU
27	anaplastic plasmacytoma	13.7	PCNA, MKI67, PLAU, GFAP
28	lung giant cell carcinoma	13.7	PCNA, CDKN2A, MMP2, TIMP2
29	anaplastic ganglioglioma	13.7	S100B, GFAP, NES
30	hepatocellular carcinoma (fibrolamellar variant)	13.7	MMP2, MMP9, PLAU, PLAUR
31	juvenile myelomonocytic leukemia	13.6	ANXA2, TP53, PTEN, PDGFRA, PDGFRB
32	male germ cell tumor	13.6	CDKN2A, MGMT, MDM2, CCNA2, CCND2, TP53
33	myoma	13.6	CDKN2A, MDM2, EGFR
34	macular holes	13.6	VEGFA, PTGDS, GFAP, ADM
35	myoepithelial carcinoma	13.6	PCNA, S100A1, GFAP
36	oropharyngeal cancer, adult	13.6	CDKN2A, TP53, EGFR
37	conjunctivochalasis	13.6	MMP2, MMP9, PLAU, TIMP2
38	thyroid lymphoma	13.6	CDKN2B, CDKN2A, CCNB1, CCNA2, TP53, TP73
39	spindle cell lipoma	13.6	S100A1, CDK4, MDM2
40	skin carcinoma	13.6	CDK4, MMP2, TP53, THBS1
41	refractive error	13.6	MMP12, MMP2, MMP9, TIMP2
42	actinic cheilitis	13.6	MMP9, MKI67, MDM2, TP53
43	moyamoya disease	13.6	MMP12, MMP2, MMP9, PDGFRB, TIMP2
44	cerebral aneurysms	13.6	MMP2, MMP9, CTSB, TIMP2
45	abdominal aortic aneurysm	13.6	MMP12, MMP2, MMP9, PLAU, TIMP2
46	pelvic inflammatory disease	13.6	MMP2, MMP9, CTSB, PLAU
47	ollier disease	13.6	MMP12, MMP2, IDH1, CTSB, PLAU
48	cheilitis	13.6	MMP9, MKI67, MDM2, TP53
49	myxopapillary ependymoma	13.6	LGALS3, S100B, GFAP
50	gingival overgrowth	13.6	PCNA, BSG, CTSB, EGFR, THBS1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to anaplastic astrocytoma:

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MGI Mouse Phenotypes related to anaplastic astrocytoma:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.8	OLIG2, IL13RA1
2	craniofacial phenotype	MP:0005382	10.1	PDGFRB, PDGFRA, TERF1, TP73, FGFR2
3	endocrine/exocrine gland phenotype	MP:0005379	10.1	SHC1, TERF1, CDKN2B, FGFR2, EPHB6
4	liver/biliary system phenotype	MP:0005370	9.8	FOXM1, ADM, EGFR, NR1H2, TP53, VEGFA
5	renal/urinary system phenotype	MP:0005367	9.6	CTSB, EGFR, EPHB6, CDK4, CDKN2B, FGFR2
6	no phenotypic analysis	MP:0003012	9.3	VEGFA, EGFR, OLIG2, PTK2, TERF1, TP53
7	hematopoietic system phenotype	MP:0005397	9.1	CDK4, CDKN2B, LGALS3, PCNA, FGFR2, EPHB6
8	pigmentation phenotype	MP:0001186	8.7	CDKN2A, FGFR2, MDM2, TP53, TERF1, PTEN
9	limbs/digits/tail phenotype	MP:0005371	8.0	VEGFA, MMP9, THBS1, EGFR, PDGFRA, SRC
10	embryogenesis phenotype	MP:0005380	8.0	MDM2, EGFR, SHC1, CDH2, CDK4, FGFR2
11	digestive/alimentary phenotype	MP:0005381	7.9	ERBB2, MDM2, FGFR2, MMP9, CDKN2A, LGALS3
12	normal phenotype	MP:0002873	7.8	IGF1, TNC, TERF1, TERT, NR1H2, PDGFRA
13	vision/eye phenotype	MP:0005391	7.5	MMP2, CCND2, CDKN2A, CCND1, CDK4, MMP9
14	behavior/neurological phenotype	MP:0005386	7.4	SHC1, LGALS8, LGALS1, RB1, SRC, EPHB6
15	reproductive system phenotype	MP:0005389	7.0	VEGFA, CDKN2B, MMP12, MMP9, FLT1, CCND2
16	nervous system phenotype	MP:0003631	6.7	FLT1, MMP2, MMP12, CDK4, CDH2, LGALS3
17	mortality/aging	MP:0010768	6.5	PTK2, NES, ADM, GFAP, EGFR, SHC1
18	integument phenotype	MP:0010771	6.4	EPHB6, CDKN2B, CDK4, FGFR2, MDM2, CCND1
19	muscle phenotype	MP:0005369	6.4	ERBB2, TP53, PTEN, PTK2, OLIG2, NR1H2
20	skeleton phenotype	MP:0005390	6.0	THBS1, SRC, RB1, TP73, TNFSF10, TERT
21	immune system phenotype	MP:0005387	6.0	S100A4, FSCN1, CDKN2B, CDK4, MMP12, FOXM1
22	growth/size phenotype	MP:0005378	5.9	CTSB, OLIG2, OLIG1, PTK2, PTEN, PLAU
23	cardiovascular system phenotype	MP:0005385	5.6	MMP12, CDH2, MMP2, LGALS3, VEGFA, CDK4
24	tumorigenesis	MP:0002006	4.9	IGF1, CDKN2B, S100A4, RB1, CDKN2A, CDK4
25	homeostasis/metabolism phenotype	MP:0005376	4.3	IL13RA1, DMBT1, PTK2, PTEN, TERT, TERF1
26	cellular phenotype	MP:0005384	3.9	CCND2, DMBT1, OLIG2, SRC, ODC1, CTSB

Articles related to anaplastic astrocytoma:

(show all 31)

id	Title	Authors	Year	Affiliating Genes
1	Overexpression of c-erbB2 is a negative prognostic fa ctor in anaplastic astrocytomas. (20331873)	Gulati S.... Torp S.H.	2010	ERBB2, EGFR
2	Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation stat us accounts for the unfavorable prognostic effect of higher age: implications f or classification of gliomas. (21088844)	Hartmann C.... von Deimling A.	2010	IDH1
3	Corneal verticillata after dual anti-epidermal growth factor receptor and anti-vascular endothelial growth factor receptor 2 therapy (vandetanib) for anaplastic astrocytoma. (19512898)	Yeh S.... Smith J.A.	2009	EGFR
4	MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma. (18945611)	Sadones J.... Neyns B.	2009	MGMT
5	Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma. (19876867)	Anselmo N.P.... Casartelli C.	2009	TP53, TP73
6	Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)	Fernandez A.... Wass J.A.	2008	IGF1
7	Multifocal anaplastic astrocytoma in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS2 mutation. (17993636)	Gururangan S.... Friedman H.S.	2008	TCN2
8	Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. (18852145)	Payne C.A.... McDonald K.L.	2008	PTGDS
9	Prognostic factors for anaplastic astrocytomas. (17001519)	Compostella A.... Brandes A.A.	2007	MCM3
10	Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocytoma. (17683572)	Fujimaki T.... Nakagomi T.	2007	MGMT
11	The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas. (17520179)	Takaya S.... Roncaroli F.	2007	TSPO
12	Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma. Case report. (17639893)	Kanamori M.... Tominaga T.	2007	TP53
13	Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas. (17691113)	Grasbon-Frodl E.M.... Kretzschmar H.A.	2007	MGMT
14	Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma. (15671553)	Soling A.... Rainov N.G.	2005	MCM3
15	Differences in vasculature between pilocytic and anaplastic astrocytomas of childhood. (14595708)	Gesundheit B.... Becker L.	2003	FLT1
16	Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma. (12700122)	Ushio Y.... Saya H.	2003	MDM2, EGFR, TP53
17	FAK signaling in anaplastic astrocytoma and glioblastoma tumors. (12784878)	Natarajan M.... Gladson C.L.	2003	PTK2
18	Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples. (11980671)	Hecker T.P.... Gladson C.L.	2002	SRC, PTK2, SHC1
19	Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein D as a marker for low-grade, non-infiltrating primary CNS neoplasms. (11895042)	Hunter S.... Neish A.	2002	APOD
20	Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. (11431323)	Sonoda Y.... Pieper R.O.	2001	EGFR
21	Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma. (11559533)	Sonoda Y.... Pieper R.O.	2001	TERT
22	Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. (11145198)	Camby I.... Kiss R.	2001	LGALS3, LGALS1, LGALS8
23	Redifferentiation therapy in brain tumors: long-lasti ng complete regression of glioblastomas and an anaplastic astrocytoma under lon g term 1-alpha-hydroxycholecalciferol. (11349882)	Trouillas P.... Gerard J.P.	2001	NR1H2
24	PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. (11504770)	Smith J.S.... Jenkins R.B.	2001	EGFR, TP53, PTEN
25	Prognostic factors in recurrent glioblastoma multiforme and anaplastic astrocytoma treated with selective intra-arterial chemotherapy. (10730637)	Chow K.L.... ViA+uela F.	2000	KNG1
26	Supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas are characterized by a differential expression of S100 proteins. (9989446)	Camby I.... Decaestecker C.	1999	S100B, S100A4, S100A2
27	MIB-1 and p53 immunocytochemistry for differentiating pilocytic astrocytomas and astrocytomas from anaplastic astrocytomas and glioblastomas in children and young adults. (9839169)	Matsumoto T.... Sato K.	1998	TP53
28	The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325 (11324578)	Zhu B.G.... Chen Y.Z.	1998	DYT10
29	Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan. (8603418)	Danks M.K.... Whipple D.O.	1996	TOP1, BLZF1
30	Aberrant p53 expression does not correlate with the prognosis in anaplastic astrocytoma. (7477776)	Danks R.A.... Kaye A.H.	1995	TP53
31	High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas. (8108140)	Lang F.F.... Newcomb E.W.	1994	TP53

Genes related to anaplastic astrocytoma according to GeneCards:

(show top 50)    (show all 81)

id	Symbol	Description	Score	GeneCards Section Context
1	OLIG1	oligodendrocyte transcription factor 1	11.0
2	S100A5	S100 calcium binding protein A5	11.0	Publications
3	S100A3	S100 calcium binding protein A3	11.0	Publications
4	OLIG2	oligodendrocyte lineage transcription factor 2	11.0
5	MCM3	minichromosome maintenance complex component 3	11.0	Publications
6	IL13RA1	interleukin 13 receptor, alpha 1	11.0
7	FOXM1	forkhead box M1	11.0
8	APOD	apolipoprotein D	11.0	Publications
9	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0
10	S100A6	S100 calcium binding protein A6	11.0	Publications
11	TERF1	telomeric repeat binding factor (NIMA-interacting) 1	11.0
12	ADM	adrenomedullin	11.0
13	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0
14	DMBT1	deleted in malignant brain tumors 1	11.0
15	NES	nestin	11.0
16	ANXA2	annexin A2	11.0
17	TUBG1	tubulin, gamma 1	11.0
18	CCND2	cyclin D2	11.0
19	MMP12	matrix metallopeptidase 12 (macrophage elastase)	11.0
20	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
21	FGFR4	fibroblast growth factor receptor 4	11.0
22	ODC1	ornithine decarboxylase 1	11.0
23	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
24	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0
25	PTEN	phosphatase and tensin homolog	11.0	Publications
26	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Functions, Publications
27	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0
28	TP73	tumor protein p73	11.0	Publications
29	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	11.0
30	CDK4	cyclin-dependent kinase 4	11.0	Functions
31	CCNB1	cyclin B1	11.0
32	CCNA2	cyclin A2	11.0
33	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0
34	CTSB	cathepsin B	11.0
35	TNC	tenascin C	11.0
36	TIMP2	TIMP metallopeptidase inhibitor 2	11.0
37	THBS1	thrombospondin 1	11.0
38	BSG	basigin (Ok blood group)	11.0
39	TYMP	thymidine phosphorylase	11.0
40	PLAUR	plasminogen activator, urokinase receptor	11.0
41	GFAP	glial fibrillary acidic protein	11.0
42	PLAU	plasminogen activator, urokinase	11.0
43	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	11.0
44	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0
45	RB1	retinoblastoma 1	11.0
46	PCNA	proliferating cell nuclear antigen	11.0
47	MKI67	antigen identified by monoclonal antibody Ki-67	11.0
48	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
49	FGFR2	fibroblast growth factor receptor 2	11.0
50	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications

Pathways related to anaplastic astrocytoma according to GeneDecks:

(show top 50)    (show all 129)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.8	PCNA
2	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.5	CCND2, CCNA2, MDM2, CDK4
3	Transcription P53 signaling pathway10	10.5	CDKN2A, TP53, VEGFA
4	Pathway_PA16598005034	10.2	PDGFRA, FGFR4, FGFR2, FLT1, PDGFRB
5	Angiogenesis3	10.0	PDGFRB, FGFR2, MMP9, TIMP2, MMP2, TYMP
6	Breast Cancer Regulation by Stathmin136	9.8	FGFR4, CCNB1, EGFR, EPHB6, ERBB2, FGFR2
7	Transcription_P53 signaling pathway41	9.7	VEGFA, RB1, CDKN2A, FLT1, MMP2, MDM2
8	Cell adhesion_ECM remodeling41	9.6	MMP9, MMP12, IGF1, PLAUR, TIMP2, EGFR
9	Cell adhesion ECM remodeling10	9.6	MMP12, MMP2, MMP9, PLAU, PLAUR, EGFR
10	Glioblastoma Multiforme36	9.6	PDGFRB, EGFR, PDGFRA, SRC, PTEN, MGMT
11	Non-small cell lung cancer20	9.6	CDKN2A, CDK4, ERBB2, RB1
12	PTEN Pathway36	9.6	FGFR2, FGFR4, MDM2, TP53, TNC, PTK2
13	JNK Pathway36	9.5	FLT1, PDGFRB, TNFSF10, TP53, FGFR4, PDGFRA
14	GADD45 Pathway36	9.5	PCNA, CCNA2, CCND2, CCND1, TP53, CCNB1
15	Cell cycle_Cell cycle (generic schema)41	9.5	CCNA2, CCND1, CCND2, CCNB1, CDK4, RB1
16	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.5	MDM2, PCNA, CCND1, TP53, CDK4, CCNA2
17	Cell cycle Cell cycle (generic schema)10	9.4	CCND1, CCNB1, RB1, CDK4, CCNA2, CCND2
18	G1-S Phase Transition36	9.4	CDK4, CCNA2, CCND2, CDKN2B, TP53, RB1
19	p53 Mediated Apoptosis36	9.4	FGFR4, FGFR2, TIMP2, MDM2, EGFR, PDGFRB
20	Mitochondrial Apoptosis36	9.4	IGF1, EGFR, FLT1, FGFR2, FGFR4, MDM2
21	Cyclins and Cell Cycle Regulation36	9.4	TP53, CCNB1, RB1, CCNA2, CDKN2A, CDK4
22	Cellular Apoptosis Pathway36	9.3	TIMP2, FGFR2, CDKN2A, FLT1, FGFR4, MDM2
23	Signal transduction PTEN pathway10	9.3	SHC1, PTEN, SRC, PCNA, IGF1
24	Alzheimers Disease Pathway36	9.2	FGFR4, PDGFRB, ERBB2, SRC, FGFR2, PDGFRA
25	Akt Signaling36	9.2	PTK2, CCND1, MDM2, CCND2, PDGFRA, PDGFRB
26	Apoptotic Pathways in Synovial Fibroblasts36	9.2	TIMP2, PDGFRA, TP53, FGFR4, IGF1, FGFR2
27	Cell cycle20	9.2	MDM2, MCM3, TP53, CCNA2, CCND1, CCND2
28	Telomerase Components in Cell Signaling36	9.1	TP53, PDGFRB, PDGFRA, EGFR, TERF1, IGF1
29	Cell Cycle / Checkpoint Control3	9.0	TP73, TP53, CCND1, CCND2, CCNA2, CCNB1
30	p53 signaling pathway20	8.9	CDKN2A, CDK4, CCND1, IGF1, TP53, CCNB1
31	Melanoma20	8.8	CDKN2A, PDGFRA, TP53, RB1, CDK4, MDM2
32	CDC42 Pathway36	8.7	PDGFRA, FLT1, FGD1, FGFR2, FGFR4, ERBB2
33	ILK Signaling36	8.6	EPHB6, FGFR4, IGF1, ERBB2, CDH2, TNC
34	14-3-3 Induced Intracellular Signaling36	8.5	TUBG1, ERBB2, FGFR2, FGFR4, SRC, TP73
35	Glioma20	8.5	PTEN, PDGFRA, PDGFRB, SHC1, EGFR, CDKN2A
36	Tyrosine Kinases / Adaptors3	8.5	ANXA2, FLT1, PDGFRA, PDGFRB, SHC1, EGFR
37	Calpain Protease Regulates Cellular Mechanics36	8.4	CDK4, CCNB1, CCNA2, SRC, PTK2, CCND1
38	Bladder cancer20	8.4	VEGFA, RB1, MMP9, MDM2, CCND1, ERBB2
39	Prostate cancer20	8.3	ERBB2, EGFR, RB1, FGFR2, MDM2, CCND1
40	Molecular Mechanisms of Cancer36	8.3	PTK2, PDGFRA, EGFR, TIMP2, EPHB6, PTEN
41	Rho Family GTPases36	8.2	PDGFRA, PTK2, TNFSF10, TNC, IGF1, CDH2
42	p38 Signaling36	8.0	IL13RA1, FGFR4, FLT1, FGFR2, EPHB6, TIMP2
43	ERK Signaling36	8.0	EGFR, FLT1, FGFR2, FGFR4, EPHB6, ERBB2
44	Pathways in cancer20	8.0	TP53, MDM2, RB1, VEGFA, CDKN2B, CDK4
45	Paxillin Interactions36	8.0	EPHB6, FLT1, FGFR4, IGF1, ERBB2, PTK2
46	GPCR Pathway36	7.8	ERBB2, PDGFRA, EPHB6, PTK2, TIMP2, EGFR
47	MAPK Signaling36	7.7	TP53, ERBB2, IGF1, FGFR4, FGFR2, TNC
48	Focal adhesion20	7.6	THBS1, EGFR, SHC1, SRC, PDGFRB, FLT1
49	Estrogen Pathway36	7.4	FLT1, EPHB6, IGF1, SRC, PDGFRA, PDGFRB
50	Pancreatic Adenocarcinoma36	6.6	CCND1, CCND2, CCNA2, CCNB1, MDM2, FGFR4

Compounds related to anaplastic astrocytoma according to GeneDecks:

(show top 50)    (show all 324)

id	Compound	Score	Top Affiliating Genes
1	egcg32	9.9	ODC1, PDGFRB, SHC1, TOP1, TIMP2
2	glucose32	9.8	LGALS1, S100B, CDK4, MKI67, MGMT, FGFR2
3	h2o232	9.7	BLZF1, LGALS3, FGFR2, CCNB1, ODC1, PDGFRB
4	p00232	9.0	RB1, MMP9, MKI67, FLT1, MGMT, MDM2
5	estradiol32 9 18 9	11.6	PCNA, RB1, CDK4, MKI67, MDM2, CCNB1
6	irinotecan32 34 9 9	11.5	VEGFA, CDKN2A, MKI67, MGMT, MDM2, CCNA2
7	bromodeoxyuridine32	8.4	PCNA, RB1, S100B, CDK4, MKI67, FGFR2
8	oxygen32 18	9.3	RB1, BLZF1, LGALS1, LGALS3, CDKN2A, CDK4
9	rapamycin32 42	9.3	RB1, VEGFA, LGALS1, CDK4, FLT1, MDM2
10	silymarin32	8.1	PCNA, VEGFA, CDK4, MMP2, MMP9, CCNB1
11	5-aza-2deoxycytidine32	8.0	PCNA, S100A2, S100A4, CDH2, CDKN2B, CDKN2A
12	cholesterol32 9 18 9	11.0	RB1, BSG, BLZF1, CDKN2A, FLT1, FGFR4
13	cyclosporin a32 42	9.0	BSG, BLZF1, S100B, CDK4, MMP9, CCNA2
14	butyrate32	7.7	RB1, BLZF1, LGALS1, LGALS3, CDKN2A, CDK4
15	docetaxel32 34 9 9	10.7	VEGFA, CDKN2A, MDM2, CCNB1, CCNA2, ERBB2
16	nitric oxide32 9 18 9	10.6	RB1, LGALS3, S100A1, S100B, CDKN2A, CDK4
17	gefitinib32 34 9 9	10.6	VEGFA, CDK4, MMP2, MMP9, MDM2, CCND1
18	etoposide32 42 9 9	10.5	PCNA, RB1, LGALS1, LGALS3, S100B, MMP2
19	ly29400232	7.5	VEGFA, MMP2, MMP9, CCNA2, CCND1, ERBB2
20	heparin32 9 18 9	10.5	BSG, LGALS1, LGALS3, FLT1, FGFR2, FGFR4
21	agar32	7.4	RB1, LGALS1, CDKN2A, CDK4, FOXM1, FGFR2
22	flavopiridol32 9 9	9.4	RB1, VEGFA, CDKN2A, CDK4, MDM2, CCNA2
23	arginine32	7.4	BLZF1, LGALS1, S100B, CDK4, FGFR4, MDM2
24	lipid32	7.3	RB1, BSG, BLZF1, LGALS1, LGALS3, S100B
25	formaldehyde32 18	8.3	PCNA, RB1, BLZF1, LGALS3, S100B, MMP9
26	curcumin32	7.2	VEGFA, CDK4, MMP2, MMP9, MGMT, MDM2
27	adriamycin32	7.1	RB1, CDKN2A, MDM2, CCNB1, CCND1, IGF1
28	thymidylate32	7.1	PCNA, RB1, VEGFA, CDKN2A, CDK4, MKI67
29	actinomycin d32	7.1	RB1, VEGFA, BLZF1, CDKN2A, MMP9, MDM2
30	resveratrol32 9 18 9	10.1	PCNA, RB1, BSG, VEGFA, CDK4, MMP2
31	imatinib32 34 9 9	10.0	VEGFA, S100B, FLT1, MDM2, CCND2, CCND1
32	glutamate32	6.9	PCNA, BSG, BLZF1, LGALS3, CDH2, MMP2
33	alanine32	6.8	PCNA, BLZF1, LGALS3, S100B, CDKN2A, CDK4
34	cysteine32	6.7	PCNA, BLZF1, LGALS1, LGALS3, S100A1, S100A2
35	calcium32 9 18 9	9.7	RB1, BLZF1, LGALS1, LGALS3, S100A1, S100A2
36	5fluorouracil32	6.7	PCNA, RB1, VEGFA, CDKN2A, CDK4, MMP2
37	paraffin32	6.6	PCNA, RB1, VEGFA, LGALS1, LGALS3, S100A1
38	matrigel32	6.5	RB1, BSG, VEGFA, LGALS1, LGALS3, S100A4
39	ag 147832	6.4	MMP2, MMP9, CCND1, IGF1, ERBB2, DYT10
40	progesterone32 42 9 18 9	10.3	PCNA, RB1, BSG, S100A1, S100A6, S100B
41	dexamethasone32 42 34 9 9	10.3	PCNA, RB1, VEGFA, LGALS1, S100B, CDH2
42	estrogen32	6.2	PCNA, BSG, LGALS3, S100A1, S100A4, S100A6
43	doxorubicin32 34 9 9	8.8	RB1, VEGFA, CDKN2A, CDK4, MKI67, FLT1
44	wortmannin32 42	6.6	LGALS3, LGALS8, S100B, MMP2, MMP9, MDM2
45	cisplatin32 34 9 9	8.3	PCNA, RB1, VEGFA, BLZF1, LGALS3, CDKN2A
46	phosphatidylinositol32	5.2	RB1, BLZF1, LGALS3, LGALS8, MMP12, MMP2
47	paclitaxel32 34 9 9	8.2	PCNA, RB1, VEGFA, S100B, CDKN2A, CDK4
48	retinoic acid32 42 18	6.9	RB1, BLZF1, LGALS3, S100A4, S100A6, S100B
49	testosterone32 9 18 9	7.4	PCNA, RB1, BLZF1, S100A6, S100B, CDH2
50	genistein32 9 18 9	6.9	PCNA, RB1, VEGFA, BLZF1, CDH2, CDKN2A

Cellular components related to anaplastic astrocytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	9.6	VEGFA, LGALS3, LGALS1, DMBT1, TNC, MMP9
2	extracellular matrix	GO:031012	9.6	THBS1, TNC, ANXA2, FGFR2, LGALS3, LGALS1
3	cyclin-dependent protein kinase holoenzyme complex	GO:000307	9.4	CCND2, CCND1, CDK4
4	perinuclear region of cytoplasm	GO:048471	9.0	CTSB, PTGDS, ERBB2, MCM3, APOD, S100B
5	nucleoplasm	GO:005654	7.9	TERT, CCNB1, NR1H2, TOP1, MGMT, CDK4
6	extracellular region	GO:005576	7.9	VEGFA, PTGDS, PLAU, PLAUR, TIMP2, THBS1
7	extracellular space	GO:005615	7.9	APOD, ADM, KNG1, TCN2, THBS1, TNC
8	cytoplasm	GO:005737	6.2	PDGFRB, NR1H2, TERF1, OLIG2, DMBT1, PTK2
9	nucleus	GO:005634	3.6	PCNA, CDKN2A, CDK4, MMP2, FOXM1, MKI67

Biological processes related to anaplastic astrocytoma according to GeneDecks:

(show all 43)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.6	PDGFRB, VEGFA, PDGFRA
2	G2/M transition of mitotic cell cycle	GO:000086	10.6	TUBG1, CCNA2, NES, TERF1, CCNB1, FOXM1
3	positive regulation of phospholipase C activity	GO:010863	10.6	FLT1, PDGFRB, PDGFRA
4	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.5	FLT1, PDGFRB, PDGFRA, VEGFA
5	cell migration	GO:016477	10.4	THBS1, PDGFRB, PTEN, FGFR4, FLT1, CDH2
6	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.3	THBS1, TSPO, PDGFRB, TP53
7	cell cycle checkpoint	GO:000075	10.2	RB1, CDKN2A, MDM2, MCM3, TP53, CCNB1
8	positive regulation of angiogenesis	GO:045766	10.2	ADM, THBS1, FLT1, MMP9, VEGFA
9	cell cycle arrest	GO:007050	10.2	CDKN2B, RB1, CDKN2A, TP53, TP73, THBS1
10	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.1	PDGFRB, FLT1, PTK2, PDGFRA
11	negative regulation of focal adhesion assembly	GO:051895	10.1	APOD, PTEN, THBS1, SRC
12	positive regulation of fibroblast proliferation	GO:048146	10.1	S100A6, CDK4, IGF1, PDGFRA, EGFR
13	replicative senescence	GO:090399	10.0	TERT, TP53, CDKN2A
14	positive regulation of MAP kinase activity	GO:043406	9.9	FLT1, EGFR, PDGFRB, ERBB2, VEGFA
15	positive regulation of cell migration	GO:030335	9.9	PDGFRB, THBS1, PDGFRA, EGFR, PTK2, FLT1
16	extracellular matrix organization	GO:030198	9.8	TIMP2, PTK2, GFAP, MMP2, LGALS3, MMP9
17	aging	GO:007568	9.7	APOD, IGFBP2, SHC1, ADM, TSPO
18	negative regulation of apoptotic process	GO:043066	9.7	PTEN, EGFR, THBS1, NES, PLAUR, VEGFA
19	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.7	PDGFRB, PDGFRA, FLT1, IGF1, PTK2
20	response to hypoxia	GO:001666	9.7	THBS1, FLT1, ADM, VEGFA, MMP9, SHC1
21	positive regulation of DNA replication	GO:045740	9.7	IGF1, PDGFRA, SHC1, EGFR
22	G1 phase of mitotic cell cycle	GO:000080	9.7	CCND1, CDK4, RB1, CDKN2B, CDKN2A
23	angiogenesis	GO:001525	9.6	MMP2, ANXA2, FGFR2, APOD, PTEN, SHC1
24	myoblast differentiation	GO:045445	9.6	LGALS1, IGF1, RB1
25	fibroblast growth factor receptor signaling pathway	GO:008543	9.6	FGFR4, MDM2, PTEN, SRC, SHC1, FGFR2
26	positive regulation of smooth muscle cell proliferation	GO:048661	9.5	PDGFRB, SHC1, IGF1, FLT1
27	response to ethanol	GO:045471	9.5	CCND1, MGMT, CTSB, CCND2, MMP9
28	phosphatidylinositol-mediated signaling	GO:048015	9.5	PCNA, IGF1, MDM2, PDGFRB, ERBB2, PDGFRA
29	G1/S transition of mitotic cell cycle	GO:000082	9.5	CCNB1, CCND1, MCM3, CDK4, CDKN2A, PCNA
30	positive regulation of epithelial cell proliferation	GO:050679	9.5	EGFR, IGF1, CCND2, FGFR2, ERBB2
31	peptidyl-tyrosine phosphorylation	GO:018108	9.5	SRC, PTK2, FGFR2, FLT1, FGFR4, PDGFRA
32	protein autophosphorylation	GO:046777	9.4	FGFR2, FGFR4, PDGFRB, PTK2, PDGFRA, ERBB2
33	mitotic cell cycle	GO:000278	9.4	CCNA2, CCNB1, MCM3, CDKN2B, PCNA, RB1
34	epidermal growth factor receptor signaling pathway	GO:007173	9.1	SHC1, SRC, ERBB2, MDM2, EGFR, PTEN
35	cell proliferation	GO:008283	9.1	EGFR, MKI67, ERBB2, TP53, PTEN, TSPO
36	negative regulation of cell proliferation	GO:008285	9.0	CDKN2B, CDKN2A, PTEN, TIMP2, IGF1, TP53
37	Ras protein signal transduction	GO:007265	9.0	CCNA2, SHC1, TP53, SRC, IGF1, CDKN2A
38	positive regulation of protein phosphorylation	GO:001934	8.8	ERBB2, CCND1, CCND2, PTK2, VEGFA
39	response to drug	GO:042493	8.8	MMP9, NES, THBS1, TOP1, LGALS1, CDK4
40	positive regulation of cell proliferation	GO:008284	8.7	ODC1, PDGFRA, PDGFRB, SHC1, EGFR, VEGFA
41	platelet activation	GO:030168	8.3	KNG1, PTK2, IGF1, THBS1, SHC1, SRC
42	blood coagulation	GO:007596	8.0	VEGFA, KNG1, THBS1, BSG, SHC1, PLAUR
43	signal transduction	GO:007165	8.0	S100A6, FGD1, SRC, LGALS1, TNFSF10, TNC

Molecular functions related to anaplastic astrocytoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet-derived growth factor receptor binding	GO:005161	10.3	TYMP, PDGFRA, PDGFRB, VEGFA
2	vascular endothelial growth factor-activated receptor activity	GO:005021	10.3	FLT1, PDGFRA, PDGFRB
3	S100 protein binding	GO:044548	10.1	S100A6, S100B, S100A1
4	calcium-dependent protein binding	GO:048306	9.9	S100A4, S100A6, S100B, DMBT1
5	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.7	EGFR, PDGFRA, ERBB2, FLT1
6	calcium ion binding	GO:005509	9.4	S100A4, THBS1, ANXA2, MGMT, MMP12, CDH2
7	protein homodimerization activity	GO:042803	9.0	VEGFA, FGFR2, S100B, S100A6, S100A5, S100A1
8	integrin binding	GO:005178	9.0	THBS1, GFAP, SRC, IGF1, TIMP2
9	protein tyrosine kinase activity	GO:004713	8.9	FGFR4, ERBB2, SRC, PDGFRB, FGFR2, EGFR
10	identical protein binding	GO:042802	8.8	THBS1, TP53, EGFR, TP73, ERBB2, MDM2
11	protein kinase binding	GO:019901	8.8	PTEN, PTK2, TP73, TP53, CCND1, CCND2
12	enzyme binding	GO:019899	8.7	BLZF1, CCND1, TP53, PTEN, PLAUR, EGFR
13	protein binding	GO:005515	2.8	PDGFRB, MKI67, FLT1, FGFR2, IL13RA1, MDM2