MCID: ANP005
MIFTS: 43

Anaplastic Astrocytoma malady

Neuronal, Cancer categories

Summaries for Anaplastic Astrocytoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Anaplastic astrocytoma is a WHO grade III type of astrocytoma. more...

MalaCards: Anaplastic Astrocytoma, also known as high-grade astrocytoma, is related to astrocytoma and pilocytic astrocytoma. An important gene associated with Anaplastic Astrocytoma is MMP12 (matrix metallopeptidase 12 (macrophage elastase)), and among its related pathways are Cell cycle and Cyclins and Cell Cycle Regulation. The compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Anaplastic Astrocytoma

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
anaplastic astrocytoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

anaplastic astrocytoma 43 45 49 61
high-grade astrocytoma 43
malignant astrocytoma 43


Related Diseases for Anaplastic Astrocytoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anaplastic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.8LGALS3, CDKN2B, NES, APOD, S100A6, TUBG1
2pilocytic astrocytoma30.7OLIG2, LGALS3, CDK4, NES, APOD
3anaplastic oligodendroglioma30.1OLIG1, CDK4, LGALS3, OLIG2, CDKN2B
4brain cancer30.1NES, CDKN2B, TERF1, IL13RA1, OLIG1, OLIG2
5colorectal cancer30.1LGALS3, FGFR4, FSCN1, CDK4
6spinal cord astrocytoma10.4
7neurofibromatosis10.2
8anaplastic oligoastrocytoma10.2
9oligoastrocytoma10.2
10glioblastoma 310.2
11phaeohyphomycosis10.2
12wilms tumor10.2
13turcot syndrome10.2
14autoimmune lymphoproliferative syndrome10.1
15newcastle disease10.1
16arteriovenous malformation10.1
17juvenile pilocytic astrocytoma10.1
18fibrillary astrocytoma10.1
19acromegaly10.1
20malignant histiocytosis10.1
21adult syndrome10.1
22central neurocytoma10.1
23adult medulloblastoma10.1
24n syndrome10.1
25pleomorphic xanthoastrocytoma10.1
26juvenile astrocytoma10.1
27gliosarcoma10.1
28brain glioblastoma multiforme10.1
29acute leukemia10.1
30ollier disease10.1
31brain disease10.1
32corpus callosum agenesis10.1
33young syndrome10.1
34diffuse astrocytoma10.1
35germinoma10.1
36t-lymphocytopenia10.1
37oral cancer10.1
38mental retardation10.1
39venous thrombosis10.1
40stroke, hemorrhagic10.1
41adult respiratory distress syndrome10.0
42tuberous sclerosis10.0
43muir-torre syndrome10.0
44tuberous sclerosis complex10.0
45laryngeal squamous cell carcinoma10.0CDKN2B
46oligodendroglioma10.0CDKN2B, OLIG2, OLIG1
47cholesteatoma10.0S100A6, LGALS3
48medulloblastoma10.0CDK4, CDKN2B, NES, CCND2
49meningioma10.0MMP12, CDKN2B, S100A5, TERF1, S100A6
50ependymoma10.0NES, CDKN2B

Graphical network of the top 20 diseases related to Anaplastic Astrocytoma:



Diseases related to anaplastic astrocytoma

Clinical Features for Anaplastic Astrocytoma

Drugs & Therapeutics for Anaplastic Astrocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Anaplastic Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Anaplastic Astrocytoma

Search NIH Clinical Center for Anaplastic Astrocytoma

Search CenterWatch for Anaplastic Astrocytoma

Genetic Tests for Anaplastic Astrocytoma

Anatomical Context for Anaplastic Astrocytoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Anaplastic Astrocytoma:

33
Spinal cord, Brain, Bone marrow, Cortex, Cerebellum, T cells, B lymphoblasts, B cells, Endothelial, Pineal

Animal Models for Anaplastic Astrocytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Anaplastic Astrocytoma

Sources:
51PubMed
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Articles related to Anaplastic Astrocytoma:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
The genetic landscape of anaplastic astrocytoma. (24140581)
2013
2
The prognosis of anaplastic astrocytoma with radiologic necrosis mimicking glioblastoma. (22827635)
2013
3
Long-term follow-up of surgical treatment of spinal anaplastic astrocytoma in a cat. (23428584)
2013
4
Adult with cerebellar anaplastic pilocytic astrocytoma associated with BRAF V600E mutation and p16 loss. (23196000)
2013
5
A common 8q (MYC) amplification detected in a multifocal anaplastic astrocytoma by SNP array karyotyping. (22720694)
2012
6
Radiation-induced spinal cord anaplastic astrocytoma subsequent to radiotherapy for testicular seminoma. (23006885)
2012
7
Subcutaneous malignant melanoma of the scalp surgical flap after brain irradiation for anaplastic astrocytoma. (21720809)
2012
8
The role of chemotherapy in anaplastic astrocytoma patients. (22737298)
2012
9
A huge intraventricular congenital anaplastic astrocytoma: case report with histopathological and genetic consideration. (22139530)
2012
10
Intracranial metastasis of spinal intramedullary anaplastic astrocytoma. (22347337)
2011
11
PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma. (21113787)
2011
12
Anaplastic astrocytoma with angiocentric ependymal differentiation. (21062363)
2011
13
Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome (ALPS). (20846185)
2011
14
Microscopic thrombi in anaplastic astrocytoma predict worse survival? (21849253)
2011
15
Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation. (20658636)
2010
16
Intracranial dissemination from spinal cord anaplastic astrocytoma. (20157383)
2010
17
Transformation of intracranial anaplastic astrocytoma associated with neurofibromatosis type I into gliosarcoma: case report. (20466481)
2010
18
Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)
2008
19
Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease. (18414790)
2008
20
Genome-wide oligonucleotide microarray analysis of gene-expression profiles of Taiwanese patients with anaplastic astrocytoma and glioblastoma multiforme. (18812569)
2008
21
Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. (18852145)
2008
22
Anaplastic astrocytoma with eosinophilic granular cells. (18018480)
2007
23
Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma. (16570196)
2006
24
Salvage chemotherapy with cyclophosphamide for recurrent temozolomide-refractory anaplastic astrocytoma. (16323194)
2006
25
Phase II trial of carmustine, cisplatin, and oral etoposide chemotherapy before radiotherapy for grade 3 astrocytoma (anaplastic astrocytoma): results of North Central Cancer Treatment Group trial 98-72-51. (15667956)
2005
26
Mediastinal metastasis of glioblastoma multiforme evolving from anaplastic astrocytoma. (16132499)
2005
27
Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas. (15970925)
2005
28
Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors. (15234047)
2004
29
Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma. (15470710)
2004
30
Implantation metastasis along the stereotactic biopsy tract in anaplastic astrocytoma: a case report. (12675314)
2003
31
An anaplastic astrocytoma (optic chiasmatic-hypothalamic glioma) in a dog. (12949415)
2003
32
Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein D as a marker for low-grade, non-infiltrating primary CNS neoplasms. (11895042)
2002
33
Therapy-related myelodysplastic syndrome (t-MDS) in a patient with anaplastic astrocytoma: successful treatment with allogeneic bone marrow transplant. (11678432)
2001
34
Intracranial dissemination from thoracic spinal cord anaplastic astrocytoma in a patient with idiopathic CD4-positive T lymphocytopenia: a case report. (11546571)
2001
35
Retrobulbar anaplastic astrocytoma in a dog: clinicopathological and ultrasonographic features. (11002938)
2000
36
Secondary supratentorial anaplastic astrocytoma following treatment of medulloblastoma. (10476368)
1999
37
Response of recurrent glioblastoma and anaplastic astrocytoma to dibromodulcitol, BCNU and procarbazine--a phase-II study. (9524094)
1998
38
CCNU overdose during PCV chemotherapy for anaplastic astrocytoma. (9591226)
1998
39
A phase I-II trial of lovastatin for anaplastic astrocytoma and glioblastoma multiforme. (9856659)
1998
40
Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. (9669344)
1998
41
Comment on "survival improvement in anaplastic astrocytoma, combining external radiation with halogenated pyrimidines: final report of RTOG 86-12, Phase I-II Study". (8985057)
1996
42
Rapid resolution following chemotherapy of Broca's dysphasia due to recurrent anaplastic astrocytoma. (7917094)
1994
43
Tumorigenic, invasive, karyotypic, and immunocytochemical characteristics of clonal cell lines derived from a spontaneous canine anaplastic astrocytoma. (8320182)
1993
44
Anaplastic astrocytoma of an oncocytic type occurring in the cerebellar vermis in Pierre Robin syndrome--case report. (1282685)
1992
45
Epileptogenic anaplastic astrocytoma imaged only by T2-weighted magnetic resonance studies: clinical and surgical implications. (1472319)
1992
46
Anaplastic evolution of childhood optico-hypothalamic pilocytic astrocytoma: report of an autopsy case. (3208464)
1988
47
Congenital anaplastic astrocytoma with favorable prognosis. Case report. (3047342)
1988
48
Multiple primary intracranial tumors of different cell types: association of anaplastic astrocytoma and acoustic neurinoma--with review of the literature. (7179095)
1982
49
Cerebrospinal fluid polyamines in patients with Glioblastoma multiforme and anaplastic astrocytoma. (6253059)
1980
50
Anaplastic astrocytoma following radiation for a glomus jugular tumor. (222421)
1979

Genetic Variations for Anaplastic Astrocytoma

Expression for genes affiliated with Anaplastic Astrocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Astrocytoma

Search GEO for disease gene expression data for Anaplastic Astrocytoma.

Pathways for genes affiliated with Anaplastic Astrocytoma

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 4Cell Signaling Technology
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Compounds for genes affiliated with Anaplastic Astrocytoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1paraffin4510.5NES, ADM, LGALS3, FSCN1, FGFR4, CDK4
2progesterone45 60 29 11 2414.5NES, S100A6, LGALS3, CDK4, APOD, CCND2
3vegf4510.5IL13RA1, MMP12, NES, LGALS3, FGFR4, CDK4
4phosphatidylinositol4510.4CDK4, MMP12, FGFR4, LGALS3, ADM, CCND2
5oligonucleotide4510.4CCND2, S100A6, APOD, FOXM1, CDK4, MMP12
6sucrose45 11 2412.4LGALS3, CDK4, CCND2, TUBG1
7tyrosine4510.4MMP12, FSCN1, LGALS3, ADM, IL13RA1, FGFR4
8retinoic acid45 2411.4ADM, CCND2, S100A6, APOD, FOXM1, NES
9steroid4510.3S100A6, ADM, CDK4, FOXM1
10nitric oxide45 11 2412.3ADM, LGALS3, IL13RA1, CDK4, MMP12, NES
11matrigel4510.3LGALS3, MMP12, NES, ADM
1212-o-tetradecanoylphorbol 13-acetate4510.0CDK4, ADM, FSCN1, FOXM1

GO Terms for genes affiliated with Anaplastic Astrocytoma

Sources:
16Gene Ontology
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Cellular components related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.1S100A6, S100A3, FOXM1, NES, CDKN2B, FGFR4
2cyclin-dependent protein kinase holoenzyme complexGO:00030710.1CDK4, CCND2
3nucleusGO:00563410.0S100A5, FOXM1, CDKN2B, CDK4, MCM3, FGFR4

Biological processes related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron fate commitmentGO:04866310.4OLIG2, OLIG1
2G2/M transition of mitotic cell cycleGO:00008610.0TERF1, CDKN2B, NES, FOXM1, TUBG1

Molecular functions related to Anaplastic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.0ADM, CCND2, S100A6, APOD, FOXM1, CDKN2B

Products for genes affiliated with Anaplastic Astrocytoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anaplastic Astrocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet