MCID: ANP006
MIFTS: 36

Anaplastic Ependymoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Anaplastic Ependymoma

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 An ependymoma is a tumor that forms when cells in the central nervous system (including the brain and spinal cord) begin to multiple rapidly.  an anaplastic ependymoma is one in which the cells are significantly unusual and grow very quickly.  ependymomas can occur at any age; when they occur in children, they are more frequently located in the brain, whereas they are more often found in the spinal cord of affected adults.  symptoms of an ependymoma depend on the age of the patient and the size and location of the tumor.  though the exact cause of ependymoma is not yet known, it is thought that changes (mutations) in certain genes allow the cells to begin growing quickly.  treatment for ependymoma begins with surgery to remove as much of the tumor as possible, and may include other therapies as well.  of all individuals diagnosed with an ependymoma, approximately half are alive five years after their initial diagnosis. last updated: 3/27/2012

MalaCards: Anaplastic Ependymoma, also known as high-grade ependymoma, is related to myxopapillary ependymoma and malignant ependymoma. An important gene associated with Anaplastic Ependymoma is RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A), and among its related pathways are DNA damage Role of SUMO in p53 regulation and Glioma. The compounds estrogen and vincristine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Anaplastic Ependymoma

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

anaplastic ependymoma 42 44 48 60
high-grade ependymoma 48


External Ids:

SNOMED-CT via Orphanet57 21589007

Related Diseases for Anaplastic Ependymoma

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17GeneCards, 18GeneDecks
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Diseases related to Anaplastic Ependymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1myxopapillary ependymoma30.1S100B, GFAP
2malignant ependymoma30.1NF2, GFAP
3gliosarcoma30.1PTEN, GFAP
4meningioma30.1S100B, NF2, MUC1, GFAP, PTEN
5spinal cord ependymoma10.3
6cervicitis10.2
7meningitis10.2
8cerebritis10.1
9pediatric ependymoma10.1
10ganglioglioma10.1
11malignant adult ependymoma10.1
12brain ependymoma10.1
13encephalitis10.1
14ependymoblastoma10.1
15fungal meningitis10.1
16hydrocephalus10.1
17granular cell tumor10.0S100B
18angiosarcoma10.0MUC1
19leiomyoma10.0S100B
20dermatofibrosarcoma10.0MDM2
21clear cell ependymoma10.0MUC1
22choroid plexus papilloma10.0GFAP
23pancreatic cancer10.0MUC1
24rhabdoid tumor10.0MUC1
25herpes simplex10.0NF2
26secretory meningioma10.0MUC1
27extraskeletal myxoid chondrosarcoma10.0C11orf95
28ganglioneuroblastoma10.0S100B
29subependymal giant cell astrocytoma10.0GFAP
30thyroid cancer10.0PTEN
31gastrointestinal stromal tumor10.0S100B, NF2
32uterine sarcoma10.0MDM2
33osteosarcoma10.0NF2, MDM2
34benign meningioma10.0NF2, MDM2
35perineurioma10.0S100B, MUC1
36testicular cancer10.0MGMT
37familial adenomatous polyposis10.0MGMT
38transitional meningioma10.0NF2, MUC1
39spindle cell sarcoma10.0MUC1, S100B
40papillary ependymoma10.0GFAP, S100B
41tanycytic ependymoma10.0NF2, GFAP
42retinoblastoma10.0MDM2, GFAP
43choroid plexus carcinoma10.0GFAP, S100B
44bladder carcinoma10.0MDM2
45paraganglioma10.0S100B, GFAP
46liposarcoma10.0C11orf95, MDM2
47sex cord-gonadal stromal tumor10.0S100B, MUC1
48pineocytoma10.0GFAP, S100B
49ischemia10.0NF2, GFAP
50malignant mixed mullerian tumor10.0MUC1, S100B

Graphical network of the top 20 diseases related to Anaplastic Ependymoma:



Diseases related to anaplastic ependymoma

Clinical Features for Anaplastic Ependymoma

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Drugs & Therapeutics for Anaplastic Ependymoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Anaplastic Ependymoma

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Anatomical Context for Anaplastic Ependymoma

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32MalaCards
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MalaCards organs/tissues related to Anaplastic Ependymoma:

32
Spinal cord, Brain

Animal Models for Anaplastic Ependymoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anaplastic Ependymoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0PTEN, MDM2, S100B
2MP:00053707.9MDM2, NF2, MUC1, RELA, PTEN
3MP:00053797.9PTEN, RELA, MUC1, NF2, MGMT
4MP:00020067.9MGMT, MDM2, NF2, MUC1, PTEN
5MP:00053817.6PTEN, GFAP, RELA, MUC1, MDM2
6MP:00053917.5NF2, MUC1, RELA, GFAP, PTEN
7MP:00028737.4S100B, MDM2, MUC1, RELA, GFAP, PTEN

Publications for Anaplastic Ependymoma

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Genetic Variations for Anaplastic Ependymoma

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Expression for genes affiliated with Anaplastic Ependymoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Ependymoma

Search GEO for disease gene expression data for Anaplastic Ependymoma.

Pathways for genes affiliated with Anaplastic Ependymoma

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12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 52R&D Systems, 51QIAGEN
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Pathways related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.7RELA, MDM2
2
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9.7RELA, MDM2
39.1NF2, GFAP, S100B
4
Transcription Androgen Receptor nuclear signaling
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8.9PTEN, MDM2, RELA
5
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8.9PTEN, RELA, MDM2
6
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8.9MDM2, RELA, PTEN
7
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8.9RELA, PTEN, MDM2
8
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8.9PTEN, RELA, MDM2
98.9MDM2, RELA, PTEN
10
Hide members
8.8MUC1, RELA, PTEN
118.3MDM2, NF2, PTEN, MGMT
12
Hide members
8.2S100B, PTEN, MDM2, GFAP

Compounds for genes affiliated with Anaplastic Ependymoma

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44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3GFAP
2vincristine44 49 1112.2MGMT
3mucicarmine449.8S100B, MUC1
42,3-cyclic nucleotide449.7S100B, GFAP
5n-ethyl-n-nitrosourea449.7MGMT, GFAP
6alpha-amanitin449.7GFAP, MDM2
77,12-dimethylbenz(a)anthracene449.6MDM2, MGMT
8chlorambucil44 1110.5MDM2, MGMT
9eosin449.4S100B, GFAP, MUC1
10s 100449.4S100B, MUC1, GFAP
11reticulin449.4GFAP, MUC1, S100B
12mononucleotide449.3PTEN, MGMT
13deoxyribonucleic acid449.1NF2, PTEN, MGMT
14chloramphenicol44 2 1111.1MUC1, MGMT, S100B
15trastuzumab44 49 1111.0PTEN, MDM2, MUC1
16imatinib44 49 1111.0PTEN, S100B, MDM2
17calcium44 49 11 2412.0GFAP, RELA, S100B, MUC1
18crcs449.0MGMT, MUC1, PTEN
19cyclophosphamide44 49 1110.9MGMT, MDM2, PTEN
20dexamethasone44 49 28 1111.9MDM2, MGMT, S100B, GFAP
21acth448.9S100B, MUC1, GFAP
22formaldehyde44 249.8MGMT, S100B, MUC1, GFAP
235-aza-2deoxycytidine448.7MGMT, MDM2, PTEN
24etoposide44 49 59 1111.7PTEN, MDM2, MGMT, S100B
25methotrexate44 49 1110.7MDM2, MGMT, MUC1
26paclitaxel44 49 1110.6GFAP, PTEN, MDM2, S100B
27hematoxylin448.6PTEN, S100B, GFAP, MUC1
285fluorouracil448.5PTEN, MUC1, MDM2, MGMT
29methionine448.5S100B, MGMT, GFAP, PTEN
30ethanol44 49 11 2411.5PTEN, GFAP, MUC1, S100B
31aspartate448.5PTEN, S100B, MDM2, GFAP
32estradiol44 11 2410.4MDM2, MUC1, GFAP, PTEN
33thymidine44 249.4GFAP, MUC1, S100B, MDM2, MGMT
34genistein44 28 59 2 11 2413.4PTEN, GFAP, MGMT, MDM2
35glucose448.3GFAP, MUC1, MGMT, PTEN
36nitric oxide44 11 2410.1MUC1, S100B, MGMT, MDM2, PTEN
37glycogen44 249.1PTEN, GFAP, MUC1, MDM2, S100B
38agar448.1PTEN, MDM2, NF2, MUC1, GFAP
39cyclic amp44 249.1S100B, PTEN, GFAP, MUC1, MDM2
40cisplatin44 49 59 1110.9MDM2, MGMT, MUC1, GFAP, PTEN
41retinoic acid44 248.9MUC1, MGMT, S100B, GFAP, PTEN
42testosterone44 59 11 2410.8GFAP, MUC1, S100B, MDM2, RELA, PTEN
43oxygen44 248.8RELA, PTEN, GFAP, MDM2, S100B, MUC1
44threonine447.7PTEN, GFAP, NF2, MDM2, S100B, MUC1
45tyrosine447.6NF2, MUC1, MDM2, S100B, GFAP, PTEN
46vegf447.6PTEN, GFAP, MUC1, MGMT, MDM2, S100B
47serine447.4PTEN, GFAP, RELA, MUC1, NF2, S100B
48progesterone44 59 28 11 2411.2PTEN, GFAP, NF2, MUC1, MDM2, MGMT
49cysteine447.2MDM2, MGMT, S100B, NF2, MUC1, PTEN
50paraffin446.9RELA, MUC1, NF2, GFAP, PTEN, MDM2

GO Terms for genes affiliated with Anaplastic Ependymoma

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16Gene Ontology
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Cellular components related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.9PTEN, GFAP, RELA, MUC1, NF2, MDM2

Biological processes related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to morphineGO:0432789.8MDM2, RELA
2learning or memoryGO:0076119.2PTEN, S100B
3Fc-epsilon receptor signaling pathwayGO:0380958.9PTEN, RELA, MDM2
4response to drugGO:0424938.9MGMT, MDM2, RELA
5neurotrophin TRK receptor signaling pathwayGO:0480118.9PTEN, RELA, MDM2
6long-term synaptic potentiationGO:0602918.8PTEN, GFAP, S100B
7positive regulation of cell proliferationGO:0082848.7PTEN, RELA, MDM2, S100B
8innate immune responseGO:0450878.5S100B, MDM2, RELA, PTEN

Products for genes affiliated with Anaplastic Ependymoma

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Sources for Anaplastic Ependymoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet