MCID: ANP006
MIFTS: 46

Anaplastic Ependymoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
Download this MalaCard

Summaries for Anaplastic Ependymoma

About this section
Sources:
43NIH Rare Diseases, 33MalaCards
See all sources

Fully expand this MalaCard
NIH Rare Diseases:43 An ependymoma is a tumor that forms when cells in the central nervous system (including the brain and spinal cord) begin to multiple rapidly.  an anaplastic ependymoma is one in which the cells are significantly unusual and grow very quickly.  ependymomas can occur at any age; when they occur in children, they are more frequently located in the brain, whereas they are more often found in the spinal cord of affected adults.  symptoms of an ependymoma depend on the age of the patient and the size and location of the tumor.  though the exact cause of ependymoma is not yet known, it is thought that changes (mutations) in certain genes allow the cells to begin growing quickly.  treatment for ependymoma begins with surgery to remove as much of the tumor as possible, and may include other therapies as well.  of all individuals diagnosed with an ependymoma, approximately half are alive five years after their initial diagnosis. last updated: 3/27/2012

MalaCards: Anaplastic Ependymoma, also known as high-grade ependymoma, is related to ependymoma and malignant ependymoma. An important gene associated with Anaplastic Ependymoma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Nuclear signaling by ERBB4 and EGFR Signaling Pathway. The compounds 2,3-cyclic nucleotide and n-ethyl-n-nitrosourea have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are liver/biliary system and vision/eye.

Aliases & Classifications for Anaplastic Ependymoma

About this section
Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 62UMLS, 63UMLS via Orphanet, 59SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
anaplastic ependymoma:
Age of onset: Childhood


Aliases & Descriptions:

anaplastic ependymoma 43 45 49 62
high-grade ependymoma 49


External Ids:

UMLS via Orphanet63 C0280788
SNOMED-CT via Orphanet59 21589007

Related Diseases for Anaplastic Ependymoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Anaplastic Ependymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1ependymoma31.3MUC1, GFAP, MGMT, MDM2, S100B, NF2
2malignant ependymoma30.3NF2, GFAP
3myxopapillary ependymoma30.3GFAP, S100B
4ganglioglioma30.3S100B, GFAP
5gliosarcoma30.2GFAP, PTEN
6meningioma30.0GFAP, NF2, S100B, PTEN, MUC1
7cervicitis10.3
8meningitis10.3
9cerebritis10.1
10malignant adult ependymoma10.1
11encephalitis10.1
12ependymoblastoma10.1
13fungal meningitis10.1
14hydrocephalus10.1
15headache10.1
16spinal cord ependymoma10.1NF2
17choroid plexus papilloma10.1GFAP
18subependymal giant cell astrocytoma10.1GFAP
19secretory meningioma10.1MUC1
20dermatofibrosarcoma10.1MDM2
21tanycytic ependymoma10.1GFAP, NF2
22neurilemmoma10.1GFAP, NF2
23papillary ependymoma10.1GFAP, S100B
24choroid plexus carcinoma10.1GFAP, S100B
25perineurioma10.1S100B, MUC1
26transitional meningioma10.1MUC1, NF2
27pineocytoma10.1S100B, GFAP
28myoepithelioma10.1S100B, GFAP
29neurofibromatosis10.1NF2, S100B
30spindle cell sarcoma10.1S100B, MUC1
31gastrointestinal stromal tumor10.1S100B, NF2
32oligoastrocytoma10.1GFAP, MGMT
33dermatofibrosarcoma protuberans10.1S100B, MUC1
34sex cord-gonadal stromal tumor10.0MUC1, S100B
35malignant mixed mullerian tumor10.0S100B, MUC1
36giant cell tumor10.0MUC1, S100B
37paraganglioma10.0S100B, GFAP
38adenoid cystic carcinoma10.0S100B, MUC1
39neuroendocrine carcinoma10.0MUC1, S100B
40benign meningioma10.0NF2, MDM2
41brain cancer10.0MGMT, MDM2
42malignant mesothelioma10.0MUC1, NF2
43benign mesothelioma10.0MUC1, NF2
44gliomatosis cerebri10.0PTEN, GFAP
45fibrous meningioma10.0S100B, NF2, MUC1
46intraocular melanoma10.0S100B, MDM2
47neurofibroma10.0S100B, MUC1, NF2
48syringoma10.0GFAP, S100B, MUC1
49hemangioblastoma10.0GFAP, S100B, MUC1
50chordoma10.0GFAP, S100B, MUC1

Graphical network of the top 20 diseases related to Anaplastic Ependymoma:



Diseases related to anaplastic ependymoma

Symptoms for Anaplastic Ependymoma

About this section

Drugs & Therapeutics for Anaplastic Ependymoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Anaplastic Ependymoma

Search NIH Clinical Center for Anaplastic Ependymoma

Genetic Tests for Anaplastic Ependymoma

About this section

Anatomical Context for Anaplastic Ependymoma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anaplastic Ependymoma:

33
Spinal cord, Brain, Bone

Animal Models for Anaplastic Ependymoma or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Anaplastic Ependymoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2MDM2, NF2, MUC1, PTEN
2MP:00053918.2GFAP, PTEN, MUC1, NF2
3MP:00053818.1MDM2, MUC1, PTEN, GFAP
4MP:00053797.9MGMT, PTEN, MUC1, NF2
5MP:00107717.9PTEN, MUC1, S100B, NF2, MDM2
6MP:00053867.9GFAP, PTEN, S100B, NF2, MDM2
7MP:00020067.8MDM2, NF2, MUC1, PTEN, MGMT
8MP:00028737.8GFAP, PTEN, MUC1, S100B, MDM2
9MP:00053767.8NF2, MUC1, PTEN, GFAP, MGMT

Publications for Anaplastic Ependymoma

About this section
Sources:
52PubMed
See all sources

Articles related to Anaplastic Ependymoma:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Treatment of Ovarian Anaplastic Ependymoma by an Aromatase Inhibitor. (24413241)
2014
2
Anaplastic ependymoma with holocordal and intracranial meningeal carcinomatosis and holospinal bone metastases. (23422903)
2013
3
Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide: a case report. (23163298)
2013
4
Supratentorial gross-totally resected non-anaplastic ependymoma: population based patterns of care and outcomes analysis. (24085643)
2013
5
Cisplatin and temozolomide combination in the treatment of supratentorial anaplastic ependymoma. (24192541)
2013
6
Supratentorial extraventricular anaplastic ependymoma in an adult with repeated intratumoral hemorrhage. (23546851)
2013
7
Metronomic cyclophosphamide with cisplatin and bevacizumab: a new chemotherapeutic regimen for refractory anaplastic ependymoma. (23155280)
2012
8
An anaplastic ependymoma presenting as an intrinsic brainstem glioma. (22406810)
2012
9
Tandem high-dose chemotherapy and autologous stem cell transplantation for anaplastic ependymoma in children younger than 3 years of age. (22081297)
2012
10
Cystic with mural nodule: Unusual radiological presentation of supratentorial anaplastic ependymoma. (23248684)
2012
11
Purely cortical anaplastic ependymoma. (23119204)
2012
12
Sacrococcygeal myxopapillary ependymoma with anaplastic ependymoma component in an infant. (23560014)
2012
13
Spinal intradural, extramedullary anaplastic ependymoma with an extradural component: Case report and review of the literature. (21918734)
2011
14
Extraventricular anaplastic ependymoma with metastasis to scalp and neck. (21222217)
2011
15
Isolated extracranial recurrence of anaplastic ependymoma. (20830772)
2011
16
Metachronous occurrence of a temporal ganglioglioma and a bifrontal anaplastic ependymoma: coincidence or an explainable pathological curiosity? (21501061)
2011
17
Dissemination limits the survival of patients with anaplastic ependymoma after extensive surgical resection, meticulous follow up, and intensive treatment for recurrence. (20186454)
2010
18
Recurrent posterior fossa anaplastic ependymoma with prominent chondroid metaplasia: a case report and review of literature. (21045418)
2010
19
Anaplastic ependymoma with sclerotic bone metastases. (20979177)
2010
20
A case of an anaplastic ependymoma with gliosarcomatous components. (19408092)
2009
21
Metastasizing anaplastic ependymoma in an adult. Chromosomal imbalances, metabolic and gene expression profiles. (19309408)
2009
22
Intracavitary chemotherapy (Gliadel) and oral low-dose etoposide for recurrent anaplastic ependymoma. (18425379)
2008
23
Divergent ependymal tumor (ependymoblastoma/anaplastic ependymoma) of the posterior fossa: an uncommon case observed in a child. (18827270)
2008
24
O6-Methylguanine-DNA-methyltransferase in recurring anaplastic ependymomas: PCR and immunohistochemistry. (18467255)
2008
25
Images in neuro-oncology: rapid development of osseous and chondrous metaplasia in recurrent anaplastic ependymoma. (17039399)
2007
26
Extraneural metastases in anaplastic ependymoma. (17998733)
2007
27
Recurrence in supratentorial anaplastic ependymoma. (17786000)
2007
28
Intradural extramedullary spinal anaplastic ependymoma. Case illustration. (17120902)
2006
29
Development of anaplastic ependymoma in Rasmussen's encephalitis: review of the literature and case report. (15928965)
2006
30
Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases. (16614942)
2006
31
Ectopic cervical anaplastic ependymoma. (16287493)
2005
32
Anaplastic ependymoma of the fourth ventricle causing obstrictive hydrocephalus. (17299539)
2005
33
Role of radiotherapy in anaplastic ependymoma in children under age of 3 years: results of the prospective German brain tumor trials HIT-SKK 87 and 92. (16300848)
2005
34
Long-term control of recurrent anaplastic ependymoma with extracranial metastasis: importance of multiple surgery and stereotactic radiosurgery procedures--case report. (15684601)
2004
35
Stereotactic radiosurgery for nodular dissemination of anaplastic ependymoma. (15015053)
2004
36
Supratentorial lobar anaplastic ependymoma resembling cerebral metastasis: a case report. (15521241)
2004
37
Gliosarcoma arising from an anaplastic ependymoma: a case report of a rare entity. (15116335)
2004
38
Re: B. Beuthien-Baumann, et al. Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy. Strahlenther Onkol 2003;179:819-22. (15057436)
2004
39
Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy. (14652670)
2003
40
A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor. (14566482)
2003
41
Response of recurrent anaplastic ependymoma to a combination of tamoxifen and isotretinoin. (14557591)
2003
42
Spinal seeding of anaplastic ependymoma mimicking fungal meningitis. A case report and review of the literature. (10961497)
2000
43
Adjuvant stereotactic radiosurgery for anaplastic ependymoma. (10853093)
1999
44
Anaplastic ependymoma: treatment of pediatric patients with or without craniospinal radiation therapy. (9171172)
1997
45
Cytomorphology of anaplastic ependymoma in a pleural effusion. A case report. (7762356)
1995
46
Familial anaplastic ependymoma: evidence of loss of chromosome 22 in tumour cells. (7931388)
1994
47
Anaplastic ependymoma in children--increasing incidence? (1810398)
1991
48
Anaplastic ependymoma of the spinal cord in childhood. A case report. (2203230)
1990
49
Congenital anaplastic ependymoma: a case report of familial glioma. (6499569)
1984
50
Case report. Anaplastic ependymoma of the spinal cord. (7413015)
1980

Variations for Anaplastic Ependymoma

About this section

Expression for genes affiliated with Anaplastic Ependymoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anaplastic Ependymoma

Search GEO for disease gene expression data for Anaplastic Ependymoma.

Pathways for genes affiliated with Anaplastic Ependymoma

About this section
Sources:
50PathCards, 55Reactome, 57SinoBiological, 5Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 54R&D Systems, 53QIAGEN
See all sources

Pathways related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GFAP, S100B
29.3MDM2, MUC1
39.2GFAP, S100B, NF2
49.0PTEN, MDM2
5
Show member pathways
DNA damage response38
9.0MDM2, PTEN
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.0MDM2, PTEN
79.0MDM2, PTEN
89.0MDM2, PTEN
9
Show member pathways
8.2MDM2, S100B, PTEN, GFAP
10
Show member pathways
8.2MDM2, S100B, PTEN, GFAP
118.1MDM2, NF2, PTEN, MGMT
12
Show member pathways
8.1MDM2, MUC1, PTEN, GFAP

Compounds for genes affiliated with Anaplastic Ependymoma

About this section
Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
See all sources

Compounds related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
12,3-cyclic nucleotide459.8S100B, GFAP
2n-ethyl-n-nitrosourea459.8GFAP, MGMT
3mucicarmine459.6MUC1, S100B
4alpha-amanitin459.6MDM2, GFAP
5eosin459.5S100B, MUC1, GFAP
6s 100459.5S100B, MUC1, GFAP
7reticulin459.5MUC1, S100B, GFAP
8acth459.2S100B, MUC1, GFAP
9mononucleotide459.1MGMT, PTEN
10deoxyribonucleic acid459.1PTEN, NF2, MGMT
117,12-dimethylbenz(a)anthracene459.0MDM2, MGMT
12crcs459.0PTEN, MUC1, MGMT
13formaldehyde45 2410.0MUC1, S100B, GFAP, MGMT
14imatinib45 51 1110.9S100B, MDM2, PTEN
15trastuzumab45 51 1110.8PTEN, MUC1, MDM2
16vincristine45 51 1110.8MGMT, PTEN, MDM2
17cyclophosphamide45 51 1110.7PTEN, MGMT, MDM2
185-aza-2deoxycytidine458.7MGMT, MDM2, PTEN
19methotrexate51 45 1110.7MDM2, MUC1, MGMT
20hematoxylin458.7MUC1, GFAP, PTEN, S100B
21methionine458.6GFAP, MGMT, PTEN, S100B
22ethanol45 51 24 1111.6PTEN, S100B, GFAP, MUC1
23etoposide45 51 61 1111.5PTEN, S100B, MGMT, MDM2
24aspartate458.5PTEN, MDM2, S100B, GFAP
255fluorouracil458.4MDM2, MUC1, MGMT, PTEN
26estradiol45 24 1110.4PTEN, GFAP, MDM2, MUC1
27thymidine45 249.4S100B, MDM2, MGMT, MUC1, GFAP
28genistein45 29 61 3 24 1113.4GFAP, MGMT, PTEN, MDM2
29dexamethasone45 51 29 1111.3GFAP, MGMT, MUC1, MDM2, S100B
30arginine458.3S100B, MDM2, PTEN, GFAP
31alanine458.2GFAP, PTEN, S100B, MDM2
32agar458.1NF2, MDM2, PTEN, MUC1, GFAP
33retinoic acid45 249.1MGMT, GFAP, S100B, PTEN, MUC1
34paclitaxel45 51 1110.1MDM2, MGMT, S100B, PTEN, GFAP
35glucose458.1MGMT, MUC1, PTEN, GFAP, S100B
36glycogen45 249.1GFAP, MUC1, S100B, MDM2, PTEN
37cyclic amp45 249.1MDM2, S100B, MUC1, PTEN, GFAP
38testosterone45 61 24 1111.0MUC1, PTEN, GFAP, S100B, MDM2
39oxygen45 249.0GFAP, PTEN, S100B, MDM2, MUC1
40nitric oxide45 24 1110.0MGMT, MDM2, S100B, MUC1, PTEN
41cisplatin45 51 61 1110.9PTEN, MUC1, MGMT, GFAP, MDM2
42threonine457.7PTEN, GFAP, MUC1, MDM2, NF2, S100B
43serine457.7GFAP, S100B, MUC1, NF2, MDM2, PTEN
44tyrosine457.7S100B, GFAP, PTEN, MDM2, NF2, MUC1
45vegf457.6MDM2, MGMT, GFAP, PTEN, MUC1, S100B
46estrogen457.5MDM2, MGMT, S100B, MUC1, PTEN, GFAP
47calcium45 51 24 1110.4MDM2, S100B, MGMT, MUC1, PTEN, GFAP
48paraffin457.2MDM2, MGMT, GFAP, PTEN, MUC1, S100B
49progesterone45 29 61 24 1111.2NF2, S100B, MUC1, PTEN, GFAP, MGMT
50cysteine457.2PTEN, MDM2, GFAP, MGMT, NF2, S100B

GO Terms for genes affiliated with Anaplastic Ependymoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.3MDM2, NF2, S100B, MUC1, PTEN, GFAP

Biological processes related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1learning or memoryGO:0076119.4S100B, PTEN
2DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.4MDM2, MUC1
3memoryGO:0076139.4S100B, PTEN
4cellular response to hypoxiaGO:0714569.3S100B, MDM2
5negative regulation of cell migrationGO:0303369.3NF2, PTEN
6long-term synaptic potentiationGO:0602919.0S100B, PTEN, GFAP
7response to ethanolGO:0454718.8PTEN, MGMT
8positive regulation of cell proliferationGO:0082848.7PTEN, S100B, MDM2
9response to drugGO:0424938.7MGMT, PTEN, MDM2
10innate immune responseGO:0450878.6MDM2, S100B, PTEN

Molecular functions related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.3MDM2, MUC1

Products for genes affiliated with Anaplastic Ependymoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anaplastic Ependymoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet