MCID: ANP006
MIFTS: 35

Anaplastic Ependymoma malady

Neuronal, Cancer categories

Summaries for Anaplastic Ependymoma

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 An ependymoma is a tumor that forms when cells in the central nervous system (including the brain and spinal cord) begin to multiple rapidly.  an anaplastic ependymoma is one in which the cells are significantly unusual and grow very quickly.  ependymomas can occur at any age; when they occur in children, they are more frequently located in the brain, whereas they are more often found in the spinal cord of affected adults.  symptoms of an ependymoma depend on the age of the patient and the size and location of the tumor.  though the exact cause of ependymoma is not yet known, it is thought that changes (mutations) in certain genes allow the cells to begin growing quickly.  treatment for ependymoma begins with surgery to remove as much of the tumor as possible, and may include other therapies as well.  of all individuals diagnosed with an ependymoma, approximately half are alive five years after their initial diagnosis. last updated: 3/27/2012

MalaCards: Anaplastic Ependymoma, also known as high-grade ependymoma, is related to ependymoma and gliosarcoma. An important gene associated with Anaplastic Ependymoma is S100B (S100 calcium binding protein B), and among its related pathways are Prolactin receptor signaling and Neuroscience. The compounds estrogen and vincristine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and b cells, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Anaplastic Ependymoma

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

anaplastic ependymoma 43 45 49 61
high-grade ependymoma 49


Related Diseases for Anaplastic Ependymoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anaplastic Ependymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1ependymoma31.5MGMT, MDM2, NF2, MUC1, GFAP, S100B
2gliosarcoma30.4GFAP, PTEN
3myxopapillary ependymoma30.1GFAP, S100B
4ganglioglioma30.1GFAP, S100B
5spinal cord ependymoma10.4
6brain ependymoma10.3
7bone carcinoma10.1
8pediatric ependymoma10.1
9malignant adult ependymoma10.1
10brain glioma10.1
11anaplastic ganglioglioma10.1
12rasmussen encephalitis10.1
13headache10.1
14granular cell tumor10.0S100B
15leiomyoma10.0S100B
16dermatofibrosarcoma10.0MDM2
17herpes simplex10.0NF2
18angiosarcoma10.0MUC1
19ganglioneuroblastoma10.0S100B
20liposarcoma10.0MDM2
21clear cell ependymoma10.0MUC1
22rhabdoid tumor10.0MUC1
23secretory meningioma10.0MUC1
24pancreatic cancer10.0MUC1
25choroid plexus papilloma10.0GFAP
26uterine sarcoma10.0MDM2
27familial adenomatous polyposis10.0MGMT
28bladder carcinoma10.0MDM2
29subependymal giant cell astrocytoma10.0GFAP
30fibrosarcoma10.0MDM2
31gastrointestinal stromal tumor10.0NF2, S100B
32osteosarcoma10.0MDM2, NF2
33benign meningioma10.0NF2, MDM2
34perineurioma10.0MUC1, S100B
35spindle cell sarcoma10.0S100B, MUC1
36transitional meningioma10.0NF2, MUC1
37sex cord-gonadal stromal tumor10.0MUC1, S100B
38malignant mixed mullerian tumor10.0S100B, MUC1
39papillary ependymoma10.0GFAP, S100B
40choroid plexus carcinoma10.0GFAP, S100B
41giant cell tumor10.0S100B, MUC1
42brain cancer10.0MGMT, MDM2
43adenoma10.0MGMT, MUC1
44paraganglioma10.0S100B, GFAP
45tanycytic ependymoma10.0NF2, GFAP
46malignant ependymoma10.0NF2, GFAP
47retinoblastoma10.0GFAP, MDM2
48pineocytoma10.0S100B, GFAP
49malignant mesothelioma10.0MUC1, NF2
50adenoid cystic carcinoma10.0MUC1, S100B

Graphical network of the top 20 diseases related to Anaplastic Ependymoma:



Diseases related to anaplastic ependymoma

Clinical Features for Anaplastic Ependymoma

Drugs & Therapeutics for Anaplastic Ependymoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Anaplastic Ependymoma

Drug clinical trials:

Search ClinicalTrials for Anaplastic Ependymoma

Search NIH Clinical Center for Anaplastic Ependymoma

Search CenterWatch for Anaplastic Ependymoma

Genetic Tests for Anaplastic Ependymoma

Anatomical Context for Anaplastic Ependymoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Anaplastic Ependymoma:

33
Spinal cord, Brain, B cells, Endothelial

Animal Models for Anaplastic Ependymoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Anaplastic Ependymoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9PTEN, MDM2, S100B
2MP:00053708.2NF2, PTEN, MUC1, MDM2
3MP:00020067.9MUC1, NF2, MDM2, MGMT, PTEN
4MP:00053867.8PTEN, GFAP, NF2, MDM2, S100B
5MP:00053817.8GFAP, MUC1, MDM2, PTEN
6MP:00028737.7PTEN, GFAP, MUC1, MDM2, S100B

Publications for Anaplastic Ependymoma

Sources:
51PubMed
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Articles related to Anaplastic Ependymoma:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Treatment of Ovarian Anaplastic Ependymoma by an Aromatase Inhibitor. (24413241)
2014
2
Anaplastic medullary ependymoma presenting as subarachnoid hemorrhage. (23533857)
2013
3
Anaplastic ependymoma with holocordal and intracranial meningeal carcinomatosis and holospinal bone metastases. (23422903)
2013
4
Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide: a case report. (23163298)
2013
5
Supratentorial gross-totally resected non-anaplastic ependymoma: population based patterns of care and outcomes analysis. (24085643)
2013
6
Cisplatin and temozolomide combination in the treatment of supratentorial anaplastic ependymoma. (24192541)
2013
7
Supratentorial extraventricular anaplastic ependymoma in an adult with repeated intratumoral hemorrhage. (23546851)
2013
8
Anaplastic ependymoma with ependymoblastic multilayered rosettes. (23791209)
2013
9
A headache presenting in the emergency room, a clinical manifestation of an unfortunate diagnosis (grade III left frontal anaplastic ependymoma with 1p deletion). (23912654)
2013
10
Pediatric infratentorial ependymoma: prognostic significance of anaplastic histology. (21863401)
2012
11
An anaplastic ependymoma presenting as an intrinsic brainstem glioma. (22406810)
2012
12
Clinical status epilepticus due to anaplastic cortical ependymoma. (22209145)
2012
13
Anaplastic clear cell ependymoma of the conus medullaris and cauda equina in a 3-year-old child. (22009009)
2012
14
Purely cortical anaplastic ependymoma. (23119204)
2012
15
Sacrococcygeal myxopapillary ependymoma with anaplastic ependymoma component in an infant. (23560014)
2012
16
Anaplastic ependymoma simulating glioblastoma in the cerebrum of an adult. (21833575)
2012
17
Spinal intradural, extramedullary anaplastic ependymoma with an extradural component: Case report and review of the literature. (21918734)
2011
18
Extraventricular anaplastic ependymoma with metastasis to scalp and neck. (21222217)
2011
19
Isolated extracranial recurrence of anaplastic ependymoma. (20830772)
2011
20
Metachronous occurrence of a temporal ganglioglioma and a bifrontal anaplastic ependymoma: coincidence or an explainable pathological curiosity? (21501061)
2011
21
Pediatric anaplastic parenchymal ependymoma: case report. (21110032)
2011
22
Dissemination limits the survival of patients with anaplastic ependymoma after extensive surgical resection, meticulous follow up, and intensive treatment for recurrence. (20186454)
2010
23
Anaplastic ependymoma with sclerotic bone metastases. (20979177)
2010
24
Cachexia secondary to intracranial anaplastic (malignant) ependymoma in a boxer dog. (19796316)
2009
25
Tanycytic ependymoma of the spinal cord with anaplastic cytological features. (19408091)
2009
26
Metastasizing anaplastic ependymoma in an adult. Chromosomal imbalances, metabolic and gene expression profiles. (19309408)
2009
27
Intracavitary chemotherapy (Gliadel) and oral low-dose etoposide for recurrent anaplastic ependymoma. (18425379)
2008
28
O6-Methylguanine-DNA-methyltransferase in recurring anaplastic ependymomas: PCR and immunohistochemistry. (18467255)
2008
29
Images in neuro-oncology: rapid development of osseous and chondrous metaplasia in recurrent anaplastic ependymoma. (17039399)
2007
30
Recurrence in supratentorial anaplastic ependymoma. (17786000)
2007
31
Anaplastic ependymoma with cartilaginous and osseous metaplasia: report of a rare case and review of literature. (17031556)
2007
32
Intradural extramedullary spinal anaplastic ependymoma. Case illustration. (17120902)
2006
33
Development of anaplastic ependymoma in Rasmussen's encephalitis: review of the literature and case report. (15928965)
2006
34
Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases. (16614942)
2006
35
The use of neoadjuvant chemotherapy to achieve complete surgical resection in recurring supratentorial anaplastic ependymoma. (15338180)
2005
36
Long-term control of recurrent anaplastic ependymoma with extracranial metastasis: importance of multiple surgery and stereotactic radiosurgery procedures--case report. (15684601)
2004
37
Gliosarcoma arising from an anaplastic ependymoma: a case report of a rare entity. (15116335)
2004
38
Re: B. Beuthien-Baumann, et al. Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy. Strahlenther Onkol 2003;179:819-22. (15057436)
2004
39
Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy. (14652670)
2003
40
A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor. (14566482)
2003
41
Myxopapillary ependymoma with anaplastic features. (14516321)
2003
42
Response of recurrent anaplastic ependymoma to a combination of tamoxifen and isotretinoin. (14557591)
2003
43
Parenchymal anaplastic ependymoma with intratumoral hemorrhage: a case report. (14756446)
2003
44
Anaplastic ependymoma with pleuropulmonary relapse. (14515389)
2003
45
Adjuvant stereotactic radiosurgery for anaplastic ependymoma. (10853093)
1999
46
Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. (9669344)
1998
47
Cytomorphology of anaplastic ependymoma in a pleural effusion. A case report. (7762356)
1995
48
Recurrent anaplastic ependymoma with an abnormal karyotype and c-myc proto-oncogene overexpression. (7538722)
1995
49
Familial anaplastic ependymoma: evidence of loss of chromosome 22 in tumour cells. (7931388)
1994
50
Case report. Anaplastic ependymoma of the spinal cord. (7413015)
1980

Genetic Variations for Anaplastic Ependymoma

Expression for genes affiliated with Anaplastic Ependymoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Ependymoma

Search GEO for disease gene expression data for Anaplastic Ependymoma.

Pathways for genes affiliated with Anaplastic Ependymoma

Sources:
54Reactome, 4Cell Signaling Technology, 52QIAGEN
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Compounds for genes affiliated with Anaplastic Ependymoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1estrogen4510.3GFAP
2vincristine45 50 1112.2MGMT
3mucicarmine459.7MUC1, S100B
42,3-cyclic nucleotide459.7GFAP, S100B
5n-ethyl-n-nitrosourea459.6MGMT, GFAP
6alpha-amanitin459.6MDM2, GFAP
77,12-dimethylbenz(a)anthracene459.6MGMT, MDM2
8eosin459.4S100B, GFAP, MUC1
9s 100459.4GFAP, MUC1, S100B
10reticulin459.4GFAP, S100B, MUC1
11mononucleotide459.3PTEN, MGMT
12calcium45 50 11 2412.3MUC1, GFAP, S100B
13chlorambucil45 1110.2MDM2, MGMT
14deoxyribonucleic acid459.1PTEN, NF2, MGMT
15imatinib45 50 1111.1MDM2, S100B, PTEN
16trastuzumab45 50 1111.0MDM2, PTEN, MUC1
17crcs459.0MUC1, PTEN, MGMT
18acth459.0S100B, MUC1, GFAP
19cyclophosphamide45 50 1110.9MDM2, MGMT, PTEN
20dexamethasone45 50 29 1111.9MDM2, S100B, MGMT, GFAP
21methotrexate45 50 1110.9MUC1, MDM2, MGMT
225-aza-2deoxycytidine458.9PTEN, MGMT, MDM2
23formaldehyde45 249.8S100B, MUC1, MGMT, GFAP
24etoposide45 50 60 1111.7S100B, MGMT, MDM2, PTEN
25paclitaxel45 50 1110.6S100B, GFAP, MDM2, PTEN
26hematoxylin458.6MUC1, GFAP, S100B, PTEN
275fluorouracil458.5MGMT, MDM2, PTEN, MUC1
28methionine458.5MGMT, S100B, GFAP, PTEN
29ethanol45 50 11 2411.5GFAP, PTEN, MUC1, S100B
30aspartate458.5S100B, PTEN, GFAP, MDM2
31thymidine45 249.4GFAP, S100B, MGMT, MDM2, MUC1
32estradiol45 11 2410.4MUC1, PTEN, MDM2, GFAP
33genistein45 29 60 2 11 2413.4MGMT, PTEN, MDM2, GFAP
34glucose458.3PTEN, MGMT, MUC1, GFAP
35arginine458.2GFAP, MDM2, S100B, PTEN
36nitric oxide45 11 2410.2MDM2, S100B, PTEN, MUC1, MGMT
37glycogen45 249.1S100B, PTEN, GFAP, MUC1, MDM2
38agar458.1PTEN, NF2, MDM2, GFAP, MUC1
39cyclic amp45 249.1GFAP, PTEN, MDM2, S100B, MUC1
40testosterone45 60 11 2411.1S100B, MDM2, MUC1, GFAP, PTEN
41oxygen45 249.0PTEN, S100B, MDM2, MUC1, GFAP
42retinoic acid45 249.0S100B, MGMT, GFAP, PTEN, MUC1
43cisplatin45 50 60 1110.9GFAP, MUC1, MDM2, PTEN, MGMT
44threonine457.7NF2, MUC1, MDM2, S100B, GFAP, PTEN
45serine457.7NF2, MDM2, S100B, MUC1, GFAP, PTEN
46tyrosine457.6S100B, MUC1, PTEN, GFAP, NF2, MDM2
47vegf457.6MGMT, PTEN, GFAP, S100B, MDM2, MUC1
48paraffin457.2MUC1, S100B, MGMT, MDM2, NF2, GFAP
49progesterone45 60 29 11 2411.2PTEN, GFAP, MUC1, NF2, MDM2, S100B
50cysteine457.2NF2, GFAP, S100B, MGMT, MDM2, MUC1

GO Terms for genes affiliated with Anaplastic Ependymoma

Sources:
16Gene Ontology
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Cellular components related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.3PTEN, GFAP, MUC1, NF2, MDM2, S100B

Biological processes related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1learning or memoryGO:0076119.3PTEN, S100B
2long-term synaptic potentiationGO:0602918.4PTEN, GFAP, S100B

Molecular functions related to Anaplastic Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.5MUC1, MDM2

Products for genes affiliated with Anaplastic Ependymoma

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Sources for Anaplastic Ependymoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet