ALCL
MCID: ANP001
MIFTS: 56

Anaplastic Large Cell Lymphoma (ALCL) malady

Blood, Cancer, Immune categories

Summaries for Anaplastic Large Cell Lymphoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Anaplastic large-cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma involving aberrant T-cells. It... more...

MalaCards: Anaplastic Large Cell Lymphoma, also known as ALCL, is related to lymphomatoid papulosis and b-cell lymphomas. An important gene associated with Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Rho Family GTPases and Akt Signaling. The compounds [alcl] and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A mature t-cell and nk-cell neoplasm involving aberrant t-cells.

Aliases & Classifications for Anaplastic Large Cell Lymphoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
anaplastic large cell lymphoma:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

anaplastic large cell lymphoma 8 43 10 45 49 31
alcl 43 49
ki-1+ anaplastic large cell lymphoma 61


External Ids:

Disease Ontology8 DOID:0050744
MESH via Orphanet36 D017728
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet58 277637000

Related Diseases for Anaplastic Large Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Anaplastic Large Cell Lymphoma family:

anaplastic small cell lymphoma

Diseases related to Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1lymphomatoid papulosis31.4CCR4, CCL17, GZMB, TNFRSF8, NPM1, CXCR3
2b-cell lymphomas30.9JUNB, CCL17, GZMB, TNFRSF8, NPM1, STAT3
3peripheral t-cell lymphoma30.9CCR4, GZMB, TNFRSF8, CXCR3, BCL3, ALK
4mycosis fungoides30.5CCR4, CCL17, GZMB, TNFRSF8, STAT3, CXCR3
5t-cell leukemia30.5JUNB, CCR4, TNFRSF8, STAT3, IL9
6acute leukemia30.5IL9, NPM1
7asthma30.3CCR4, CCL17, GZMB, TNFRSF8, JAK3, CXCR3
8arthritis30.3GZMB, JAK3, STAT3, CXCR3
9hepatitis c30.3CXCR3, CD99
10adenocarcinoma30.3JUNB, STAT3, MUC1
11tuberculosis30.3CCR4, GZMB, TNFRSF8, CXCR3
12celiac disease30.3GZMB
13primary cutaneous anaplastic large cell lymphoma11.2
14breast lymphoma11.0
15pediatric lymphoma10.9
16bone lymphoma10.8
17anaplastic small cell lymphoma10.8
18adult lymphoma10.7
19central nervous system lymphoma10.7
20lung lymphoma10.6
21large cell carcinoma10.6
22alk-negative anaplastic large cell lymphoma10.6
23primary bone lymphoma10.6
24n syndrome10.6
25alk-positive anaplastic large cell lymphoma10.6
26gastrointestinal lymphoma10.5
27bladder lymphoma10.5
28central nervous system lymphoma, primary10.5
29inflammatory myofibroblastic tumor10.5
30lymphoma, diffuse large cell10.5
31hemophagocytic lymphohistiocytosis10.5
32cerebral lymphoma10.5
33soft tissue sarcoma10.5
34burn scar10.4
35breast reconstruction10.4
36colon lymphoma10.4
37pancreas lymphoma10.4
38liver lymphoma10.4
39acquired immunodeficiency syndrome10.4
40malignant histiocytosis10.4
41chronic myeloid leukemia10.4
42composite lymphoma10.4
43syphilis10.4
44primary effusion lymphoma10.4
45follicular lymphoma10.4
46leukemia/lymphoma, t-cell10.4
47acute liver failure10.2
48graft versus host disease10.2
49bullous pemphigoid10.2
50strongyloidiasis10.2

Graphical network of the top 20 diseases related to Anaplastic Large Cell Lymphoma:



Diseases related to anaplastic large cell lymphoma

Clinical Features for Anaplastic Large Cell Lymphoma

Drugs & Therapeutics for Anaplastic Large Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anaplastic Large Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Anaplastic Large Cell Lymphoma

Search CenterWatch for Anaplastic Large Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Anaplastic Large Cell Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Anaplastic Large Cell Lymphoma:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Anaplastic Large Cell Lymphoma:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Anaplastic Large Cell Lymphoma

Anatomical Context for Anaplastic Large Cell Lymphoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anaplastic Large Cell Lymphoma:

33
Skin, Ovary, Liver, Spinal cord, Brain, Lymph node, Lung, Spleen, Bone marrow, Thymus, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Breast, Placenta, Testis, Myeloid, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Trachea

Animal Models for Anaplastic Large Cell Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Anaplastic Large Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0BCL3, JUNB, CCR4, CCL17, GZMB, SALL4
2MP:000539710.8TNFRSF8, GZMB, CCR4, JUNB, NPM1, JAK3
3MP:000200610.6CXCR3, NPM1, JUNB

Publications for Anaplastic Large Cell Lymphoma

Sources:
51PubMed
See all sources

Articles related to Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 832)
idTitleAuthorsYear
1
Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature. (23840974)
2013
2
ALK-positive anaplastic large cell lymphoma presenting as intradural spinal mass: first reported case and review of literature. (23082771)
2013
3
A case report of human immunodeficiency virus-associated anaplastic lymphoma kinase protein-negative anaplastic large cell lymphoma. (24010049)
2013
4
A case of primary cutaneous anaplastic large cell lymphoma with prominent epidermotropism. (22450880)
2012
5
Anaplastic large cell lymphoma of the esophagus in a pediatric patient. (21877113)
2012
6
Co-expression of CD99/MIC2 and ALK in anaplastic large-cell lymphoma tissues and its significance]. (22781601)
2012
7
Syndrome of inappropriate antidiuretic hormone secretion associated with primary cutaneous anaplastic large cell lymphoma. (22409317)
2012
8
Primary cutaneous anaplastic large cell lymphoma of the nasal tip in a child. (20825571)
2011
9
I^-catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. (20971814)
2011
10
Cytomorphology of ALK+ anaplastic large cell lymphoma displaying spindle cells mimicking a sarcomatous tumor: report of a case. (20890996)
2011
11
Superimposed linear graft-versus-host disease and secondary cutaneous involvement of anaplastic large cell lymphoma. (21697052)
2011
12
Anaplastic large cell lymphoma: twenty-five years of discovery. (21204709)
2011
13
Cutaneous anaplastic large-cell lymphoma should be evaluated for systemic involvement regardless of ALK-1 status: case reports and review of literature. (21366363)
2011
14
Anaplastic large cell lymphoma: a critical evaluation of cytomorphological features in seven cases. (19744187)
2010
15
Radiotherapy in cutaneous anaplastic large cell lymphoma. (20606998)
2010
16
Cutaneous presentation of ALK-positive anaplastic large cell lymphoma following insect bites: evidence for an association in five cases. (19951975)
2010
17
Infant anaplastic large cell lymphoma with hemophagocytic syndrome. (19863446)
2010
18
Long-term disease control of refractory anaplastic large cell lymphoma with vinblastine. (19194204)
2009
19
Primary CD30/ALK-1 positive anaplastic large cell lymphoma of the skeletal muscle in a child. (19886557)
2009
20
Anaplastic large cell lymphoma in leukemic phase: extraordinarily high white blood cell count. (19432678)
2009
21
Small cell variant of anaplastic large cell lymphoma: a 10-year review of the All Wales Lymphoma Panel database. (19723152)
2009
22
Images in haematology. Hypereosinophilia as a presenting feature of anaplastic large cell lymphoma. (17916107)
2008
23
Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma. (17965727)
2008
24
Isolated cutaneous anaplastic large cell lymphoma progressing to severe systemic disease with myocardial involvement and central nervous system infiltration. (17914741)
2008
25
Bone marrow examination has limited value in the staging of patients with an anaplastic large cell lymphoma first presenting in the skin. Retrospective analysis of 107 patients. (18782320)
2008
26
Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study. (17957029)
2008
27
Anaplastic Large Cell Lymphoma. (17511113)
2007
28
CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. (17261581)
2007
29
Identification and validation of the anaplastic large cell lymphoma signature. (17695725)
2007
30
Expression of anaplastic lymphoma kinase, tyrosine-phosphorylated STAT3, and associated factors in pediatric anaplastic large cell lymphoma: A report from the children's oncology group. (17439836)
2007
31
Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes. (17077326)
2007
32
Picture of the month: anaplastic large cell lymphoma with hemophagocytic lymphohistiocytosis. (17088522)
2006
33
Molecular diagnosis of malignant lymphoma: mantle cell lymphoma, anaplastic large cell lymphoma, and marginal zone B-cell lymphoma of malt. (16579170)
2006
34
Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma. (15883821)
2005
35
Lymphomatoid papulosis from childhood with anaplastic large-cell lymphoma of the small bowel. (15636695)
2004
36
Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. (15161657)
2004
37
Clusterin, a marker for anaplastic large cell lymphoma immunohistochemical profile in hematopoietic and nonhematopoietic malignant neoplasms. (15151211)
2004
38
Prognostic significance of MUC-1 expression in systemic anaplastic large cell lymphoma. (12796388)
2003
39
Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin's Lymphoma Classification Project. (11863096)
2002
40
Epstein-Barr virus association and ALK gene expression in anaplastic large-cell lymphoma. (11957137)
2002
41
Biochemical differences between SUDHL-1 and KARPAS 299 cells derived from t(2;5)-positive anaplastic large cell lymphoma are responsible for the different sensitivity to the antiproliferative effect of p27(Kip1). (11494142)
2001
42
Carbamazepine-induced, CD30+, primary, cutaneous, anaplastic large-cell lymphoma. (11346361)
2001
43
Dipeptidyl aminopeptidase-IV as a histochemical marker of differential diagnosis of large cell anaplastic CD30+-lymphoma and Hodgkin's disease]. (10971865)
2000
44
Anaplastic large cell lymphoma: a clinicopathologic analysis. (10725869)
1999
45
A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation. (10216106)
1999
46
The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements. (9250148)
1997
47
Uniform expression of cytotoxic molecules in anaplastic large cell lymphoma of null/T cell phenotype and in cell lines derived from anaplastic large cell lymphoma. (9253032)
1997
48
NPM/ALK gene fusion transcripts identify a distinct subgroup of null type Ki-1 positive anaplastic large cell lymphomas. (8616079)
1996
49
Transcripts of the npm-alk fusion gene in anaplastic large cell lymphoma, Hodgkin's disease, and reactive lymphoid lesions. (7579458)
1995
50
Ki-1+ anaplastic large-cell lymphoma of T-cell origin in an HIV-infected patient. (1652981)
1991

Genetic Variations for Anaplastic Large Cell Lymphoma

Expression for genes affiliated with Anaplastic Large Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Anaplastic Large Cell Lymphoma

Sources:
52QIAGEN, 30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1CCL17, JUNB, TNFRSF8, JAK3, STAT3, MUC1
2
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11.0ALK, ACVRL1, JUNB, IL9, CXCR3, STAT3
3
Hide members
11.0JAK3, STAT3, ALK, ACVRL1, TNFRSF8, CCL17
4
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10.8STAT3, CCR4, CCL17, CXCR3, CD99, JAK3
5
Hide members
10.8IL9, JUNB, BCL3, JAK3, MUC1, STAT3
6
Hide members
10.8CXCR3, TNFRSF8, ACVRL1, CCL17, CCR4, IL9
7
Hide members
10.8ALK, IL9, STAT3, JAK3, CCL17
8
Hide members
10.8STAT3, CXCR3, CCL17, CCR4, JAK3
9
Hide members
10.6JAK3, STAT3, GZMB
10
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.6JUNB, JAK3, STAT3
1110.6CXCR3, CCL17, CCR4
1210.6MIR29A, STAT3

Compounds for genes affiliated with Anaplastic Large Cell Lymphoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1[alcl]4511.5STAT3, BCL3, ACVRL1, NPM1, JAK3, TNFRSF8
2tyrosine4511.5CXCR3, MUC1, JUNB, CCR4, GZMB, TNFRSF8
3calcium45 50 11 2414.3EBP, CCR4, CXCR3, MUC1, JAK3, NPM1
4paraffin4511.3CD99, MUC1, STAT3, NPM1, TNFRSF8, GZMB
5serine4511.2ACVRL1, IL9, GZMB, JAK3, STAT3, CXCR3
6cyclosporin a45 29 6013.2STAT3, CCL17, JAK3, PPID, TNFRSF8, GZMB
7vegf4511.2GZMB, JAK3, STAT3, MUC1, CD99, ACVRL1
8threonine4511.2JUNB, TNFRSF8, NPM1, JAK3, STAT3, MUC1
9retinoic acid45 2412.1CCR4, MUC1, STAT3, JUNB, IL9, GZMB
10nitric oxide45 11 2413.1JAK3, IL9, GZMB, MUC1, CCL17, CXCR3
11rantes4511.1GZMB, STAT3, CXCR3, IL9
1212-o-tetradecanoylphorbol 13-acetate4511.1GZMB, IL9, JUNB, MUC1, STAT3
13tarc4511.0CCR4, IL9, CCL17, CXCR3
14larc4511.0CXCR3, CCR4, CCL17
15thymidine45 2412.0CXCR3, MUC1, TNFRSF8, STAT3, IL9
16dexamethasone45 50 29 1114.0STAT3, JUNB, CCL17, GZMB
17tacrolimus45 50 1113.0PPID, CXCR3, CCL17, GZMB
18ccl345 2911.9CCL17, CCR4, CXCR3
19phosphotyrosine4510.9ALK, GZMB, JAK3, STAT3
20ccl445 2911.8CCR4, CCL17, CXCR3
21estrogen4510.8JAK3
22allergens4510.8CCL17, CXCR3, IL9
23ethanol45 50 11 2413.8GZMB, MUC1, STAT3, JUNB
24tamoxifen45 50 29 1113.7JUNB, EBP
25rapamycin4510.7NPM1, GZMB, STAT3, BCL3
26actinomycin d4510.7JUNB, NPM1, STAT3, MUC1
27ly2940024510.6GZMB, CXCR3, STAT3, JAK3
28oligonucleotide4510.4JUNB, GZMB, ACVRL1, IL9, STAT3

GO Terms for genes affiliated with Anaplastic Large Cell Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1GZMB, SALL4, TNFRSF8, NPM1, PPID, STAT3
2integral to plasma membraneGO:00588710.6CCR4, EBP, MUC1, CD99, CXCR3, ACVRL1

Biological processes related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594410.7BCL3, ACVRL1, STAT3, JAK3, SALL4, JUNB
2chemotaxisGO:00693510.6CXCR3, CCL17, CCR4
3inflammatory responseGO:00695410.4CCR4, CCL17, CXCR3, IL9

Products for genes affiliated with Anaplastic Large Cell Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anaplastic Large Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet