ALCL
MCID: ANP001
MIFTS: 62

Anaplastic Large Cell Lymphoma (ALCL) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Anaplastic Large Cell Lymphoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Anaplastic large-cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma involving aberrant T-cells. It... more...

MalaCards: Anaplastic Large Cell Lymphoma, also known as ALCL, is related to lymphomatoid papulosis and hodgkin's lymphoma. An important gene associated with Anaplastic Large Cell Lymphoma is RNF213 (ring finger protein 213), and among its related pathways are Jak/Stat Pathway and Signaling events mediated by TCPTP. The compounds dfmo and chromium have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and nk cells, and related mouse phenotypes are tumorigenesis and integument.

Disease Ontology:8 A mature t-cell and nk-cell neoplasm involving aberrant t-cells.

Aliases & Classifications for Anaplastic Large Cell Lymphoma

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
anaplastic large cell lymphoma:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

anaplastic large cell lymphoma 8 43 10 45 49 31
alcl 43 49
cd30 positive anaplastic large cell lymphoma 49
ki-1 positive anaplastic large cell lymphoma 49
ki-1+ anaplastic large cell lymphoma 62
primary systemic alcl 49
sacl 49


External Ids:

Disease Ontology8 DOID:0050744
MESH via Orphanet36 D017728
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet59 277637000

Related Diseases for Anaplastic Large Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases in the Anaplastic Large Cell Lymphoma family:

Anaplastic Small Cell Lymphoma

Diseases related to Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1lymphomatoid papulosis31.3CXCR3, CCR4, ACVRL1, ALK, GZMB, NPM1
2hodgkin's lymphoma31.1MCL1, STAT3, CCR4, IL9, ALK, GZMB
3b-cell lymphomas30.9MCL1, CXCR3, STAT3, ALK, GZMB, NPM1
4peripheral t-cell lymphoma30.9MCL1, CXCR3, CCR4, ALK, GZMB
5leukemia30.8MCL1, JAK3, CXCR3, STAT3, IL9, ALK
6sarcoma30.7ALK, ACVRL1, MUC1
7dermatitis30.6CXCR3, CCR4, GZMB
8myeloid leukemia30.6MCL1, JAK3, STAT3, IL9, NPM1
9t-cell leukemia30.6STAT3, CCR4, IL9
10mycosis fungoides30.6CXCR3, STAT3, CCR4, GZMB
11pneumonia30.5MUC1
12graft versus host disease30.4GZMB, JAK3
13lung cancer30.4ALK, JAK3, MUC1
14tuberculosis30.4CXCR3, CCR4, GZMB
15chronic lymphocytic leukemia30.4MCL1, CXCR3, STAT3
16myeloma30.4ALK, STAT3, MCL1
17arthritis30.4JAK3, CXCR3, STAT3, GZMB
18breast cancer30.3GZMB, STAT3, MUC1, MCL1
19melanoma30.3MCL1, CXCR3, STAT3, CCR4, GZMB
20asthma30.3GZMB, IL9, CCR4, CXCR3, JAK3
21rheumatoid arthritis30.3MCL1, JAK3, CXCR3, CCR4, GZMB
22alk-positive anaplastic large cell lymphoma11.2
23primary cutaneous anaplastic large cell lymphoma11.2
24alk-negative anaplastic large cell lymphoma11.0
25histiocytosis10.5
26inflammatory myofibroblastic tumor10.5
27cerebritis10.5
28diffuse large b-cell lymphoma10.5
29soft tissue sarcoma10.5
30burn scar10.4
31burns10.4
32acquired immunodeficiency syndrome10.4
33malignant histiocytosis10.4
34chronic myeloid leukemia10.4
35hemophagocytic lymphohistiocytosis10.4
36adult t-cell leukemia10.4
37dermatitis herpetiformis10.4
38eosinophilia10.4
39hepatitis10.4
40mediastinitis10.4
41panniculitis10.4
42syphilis10.4
43acute liver failure10.2
44breast reconstruction10.2
45hepatitis c10.2
46langerhans-cell histiocytosis10.2
47pulmonary tuberculosis10.2
48strongyloidiasis10.2
49pemphigus10.2
50lepromatous leprosy10.2

Graphical network of the top 20 diseases related to Anaplastic Large Cell Lymphoma:



Diseases related to anaplastic large cell lymphoma

Symptoms for Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Anaplastic Large Cell Lymphoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Anaplastic Large Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Anaplastic Large Cell Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Anaplastic Large Cell Lymphoma:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Anaplastic Large Cell Lymphoma:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Anaplastic Large Cell Lymphoma

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Anatomical Context for Anaplastic Large Cell Lymphoma

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33MalaCards
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MalaCards organs/tissues related to Anaplastic Large Cell Lymphoma:

33
T cells, Breast, Nk cells, Bone, Skin, B cells, Bone marrow, Lymph node, Lung, Skeletal muscle, Myeloid, Brain, Pancreas, Liver, Colon, Endothelial, Spinal cord, Heart, Smooth muscle, Small intestine, Testis, Placenta, Ovary, Trachea

Animal Models for Anaplastic Large Cell Lymphoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Anaplastic Large Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9MUC1, CXCR3, STAT3, GZMB, NPM1
2MP:00107718.5NPM1, STAT3, MUC1, MCL1, EBP
3MP:00028738.3ACVRL1, STAT3, CXCR3, MUC1, MCL1
4MP:00053808.2EBP, MCL1, STAT3, ACVRL1, NPM1
5MP:00053818.1MUC1, JAK3, STAT3, ACVRL1, IL9
6MP:00053848.1MCL1, JAK3, CXCR3, STAT3, GZMB, NPM1
7MP:00107687.3EBP, MCL1, JAK3, CXCR3, STAT3, ACVRL1
8MP:00053877.2MCL1, JAK3, CXCR3, STAT3, CCR4, IL9
9MP:00053976.1NPM1, EBP, MCL1, JAK3, CXCR3, STAT3

Publications for Anaplastic Large Cell Lymphoma

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Sources:
52PubMed
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Articles related to Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 771)
idTitleAuthorsYear
1
Anaplastic large cell lymphoma, ALK-negative. (22789917)
2013
2
Novel TRAF1-ALK fusion identified by deep RNA sequencing of anaplastic large cell lymphoma. (23999969)
2013
3
Anaplastic large cell lymphoma in children and adolescents. (23758281)
2013
4
Clinical spectrum of primary cutaneous CD30-positive anaplastic large cell lymphoma: an analysis of the Mannheim Cutaneous Lymphoma Registry. (22525148)
2012
5
Targeting CD30 in anaplastic large cell lymphoma. (23065407)
2012
6
Primary cutaneous anaplastic large-cell lymphoma occurring in a case of chronic myeloid leukemia in remission. (22775801)
2012
7
The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. (22781692)
2012
8
Systemic Capillary Leak Syndrome as an Initial Presentation of ALK-Negative Anaplastic Large Cell Lymphoma. (22953081)
2012
9
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (21841159)
2011
10
Peripheral eosinophilia camouflaging anaplastic large cell lymphoma. (18805872)
2011
11
Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study. (22084369)
2011
12
Education and Imaging: Gastrointestinal: gastroduodenal involvement of ALK-positive anaplastic large cell lymphoma. (21488949)
2011
13
Anaplastic large cell lymphoma: a critical evaluation of cytomorphological features in seven cases. (19744187)
2010
14
Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma. (20217288)
2010
15
Resistance of cutaneous anaplastic large-cell lymphoma cells to apoptosis by death ligands is enhanced by CD30-mediated overexpression of c-FLIP. (19890350)
2010
16
Cutaneous anaplastic large cell lymphoma and peripheral T-cell lymphoma NOS show distinct chromosomal alterations and differential expression of chemokine receptors and apoptosis regulators. (19710685)
2010
17
ALK-negative anaplastic large cell lymphoma with extensive peripheral blood and bone marrow involvements manifested as "leukemic phase". (19695703)
2010
18
A phase II study of SGN-30 in cutaneous anaplastic large cell lymphoma and related lymphoproliferative disorders. (19789316)
2009
19
ALK-positive anaplastic large cell lymphoma with dic(2;4)(p23;q33). (19036440)
2009
20
Primary bone anaplastic large cell lymphoma]. (19739348)
2009
21
Primary cutaneous CD30 positive anaplastic large cell lymphoma in an adolescent. (20199449)
2009
22
Flow cytometric immunophenotyping of anaplastic large cell lymphoma. (19123736)
2009
23
Distribution of NPM1-ALK and X-ALK fusion transcripts in paediatric anaplastic large cell lymphoma: a molecular-histological correlation. (19545284)
2009
24
HIV-associated anaplastic large cell lymphoma: a report of three cases. (18753872)
2008
25
Transmission of anaplastic large cell lymphoma via organ donation after cardiac death. (18021286)
2008
26
The expression of myeloid antigens CD13 and/or CD33 is a marker of ALK+ anaplastic large cell lymphomas. (18794057)
2008
27
Images in haematology. Hypereosinophilia as a presenting feature of anaplastic large cell lymphoma. (17916107)
2008
28
A rapidly progressing, fatal case of primary systemic anaplastic large cell lymphoma presenting as erythroderma--association with carbamazepine. (19265618)
2008
29
Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature. (17396261)
2007
30
Coexistence of primary cutaneous anaplastic large cell lymphoma and mycosis fungoides in a patient with B-cell chronic lymphocytic leukaemia. (17927791)
2007
31
Differences in survivin location and Bcl-2 expression in CD30+ lymphoproliferative disorders of the skin compared with systemic anaplastic large cell lymphomas: an immunohistochemical study. (17484779)
2007
32
Anaplastic large cell lymphoma: a flow cytometric analysis of 29 cases. (17638668)
2007
33
Disseminated strongyloidiasis and cytomegalovirus infection in a patient with anaplastic large cell lymphoma. (17641892)
2007
34
Jak3 contributes to the activation of ALK and Stat3 in ALK(+) anaplastic large cell lymphoma. (16554750)
2006
35
Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma. (15117990)
2004
36
Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling. (15297316)
2004
37
The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas. (12213716)
2002
38
Anaplastic large-cell lymphoma which showed severe inflammatory status and myelodysplasia with increased VEGF and IL-6 serum levels after long-term immunosuppressive therapy. (11426493)
2001
39
Anaplastic lymphoma kinase expression as a marker of malignancy. Application to a case of anaplastic large cell lymphoma with huge granulomatous reaction. (10980638)
2000
40
Primary anaplastic large cell lymphoma of the small intestine. (10549257)
1999
41
Anaplastic large-cell lymphoma with rapid evolution to leukemic phase. (10550561)
1999
42
A murine xenograft model for human CD30+ anaplastic large cell lymphoma. Successful growth inhibition with an anti-CD30 antibody (HeFi-1). (10514417)
1999
43
Use of an anti-ALK antibody in the characterization of anaplastic large-cell lymphoma of childhood. (9187427)
1997
44
The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements. (9250148)
1997
45
Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T- and null-cell type and Hodgkin's disease: evidence for distinct cellular origin. (9028330)
1997
46
NPM/ALK gene fusion transcripts identify a distinct subgroup of null type Ki-1 positive anaplastic large cell lymphomas. (8616079)
1996
47
Cytology of extranodal Ki-1 anaplastic large cell lymphoma. (8964173)
1996
48
Primary cutaneous Ki-1+ anaplastic large cell lymphoma: a morphologic, immunohistochemical and genetic study of an indolent case. (7650245)
1995
49
Reverse transcriptase polymerase chain reaction for the Ki-1 anaplastic large cell lymphoma-associated t(2;5) translocation in Hodgkin's disease. (7527617)
1994
50
Lymphohistiocytic T-cell lymphoma (anaplastic large cell lymphoma CD30+/Ki-1 + with a high content of reactive histiocytes). (2163351)
1990

Variations for Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
50PathCards, 5Cell Signaling Technology, 60Thomson Reuters, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 30KEGG, 55Reactome
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Pathways related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.8JAK3, STAT3
29.8JAK3, STAT3
39.7STAT3, MCL1
4
Show member pathways
9.5GZMB, STAT3, JAK3
5
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.4STAT3, MCL1, JAK3
69.3STAT3, CCR4, JAK3
7
Show member pathways
9.2GZMB, ACVRL1, STAT3
8
Show member pathways
Type III interferon signaling38
9.0STAT3, IL9, JAK3
9
Show member pathways
8.9CXCR3, STAT3, CCR4, JAK3
10
Show member pathways
8.9STAT3, CXCR3, JAK3, CCR4
11
Show member pathways
8.8ALK, JAK3, STAT3, IL9
12
Show member pathways
8.8STAT3, JAK3, IL9, ALK
13
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.2MCL1, IL9, MUC1, JAK3, STAT3
14
Show member pathways
8.1IL9, CXCR3, ACVRL1, CCR4
15
Show member pathways
7.2IL9, ACVRL1, CCR4, STAT3, CXCR3, JAK3
16
Show member pathways
7.2ACVRL1, ALK, IL9, JAK3, CXCR3, STAT3
17
Show member pathways
6.8CCR4, MUC1, JAK3, CXCR3, STAT3, ACVRL1

Compounds for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB
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Compounds related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1dfmo45 29 6112.1STAT3, NPM1
2chromium4510.1MUC1, GZMB
35,6-dichloro-1-beta-d-ribofuranosylbenzimidazole4510.0NPM1, MCL1
4dasatinib45 51 1111.9STAT3, MCL1
5larc459.8CXCR3, CCR4
6agarose459.8GZMB, NPM1, MUC1
7imatinib45 51 1111.7STAT3, MCL1, GZMB
8mg 13245 6110.7MCL1, JAK3, STAT3
9curcumin459.7STAT3, JAK3, MCL1
10cytarabine45 51 1111.7MCL1, MUC1, GZMB
11phosphotyrosine459.7GZMB, ALK, STAT3, JAK3
125fluorouracil459.6MUC1, STAT3, MCL1
13matrigel459.6STAT3, CXCR3, MUC1
14rapamycin459.5GZMB, STAT3, NPM1, MCL1
15actinomycin d459.4MCL1, MUC1, STAT3, NPM1
16paclitaxel45 51 1111.4MCL1, STAT3, NPM1
17ribonucleic acid459.4MUC1, GZMB, CCR4
18cycloheximide459.4NPM1, MCL1, STAT3, JAK3
19cisplatin45 51 61 1112.4GZMB, MUC1, STAT3, MCL1
20tamoxifen45 51 29 1112.4EBP, STAT3, MUC1
21wortmannin459.4JAK3, STAT3, MCL1, CXCR3
22pge2459.3MCL1, JAK3, CXCR3, STAT3
23alanine459.3ALK, GZMB, STAT3, NPM1
24aspartate459.3MCL1, STAT3, NPM1, GZMB, ALK
25agar459.2STAT3, IL9, MUC1
26arginine459.2GZMB, STAT3, CXCR3, JAK3
27ethanol45 51 24 1112.2MUC1, STAT3, GZMB
28cholesterol45 29 24 1112.2STAT3, MUC1, CXCR3, EBP
29tarc459.1CXCR3, CCR4, IL9
30phosphatidylinositol459.1CXCR3, STAT3, ALK, JAK3, MCL1
31ly294002459.1GZMB, MCL1, JAK3, STAT3, CXCR3
32dexamethasone45 51 29 1112.0CXCR3, MUC1, GZMB, MCL1, STAT3
33thymidine45 249.9MUC1, CXCR3, IL9, STAT3
34genistein45 29 61 3 24 1113.9MCL1, STAT3, IL9, JAK3
35estrogen458.9JAK3, CXCR3, NPM1, STAT3, GZMB, MUC1
36adp45 29 2410.7ALK, ACVRL1, JAK3, CXCR3
3712-o-tetradecanoylphorbol 13-acetate458.7GZMB, MCL1, IL9, STAT3, MUC1
38nitric oxide45 24 1110.6MUC1, JAK3, CXCR3, GZMB, IL9
39rantes458.6IL9, CCR4, STAT3, CXCR3, GZMB
40threonine458.5MCL1, MUC1, JAK3, STAT3, ACVRL1, NPM1
41paraffin458.4MUC1, STAT3, CCR4, GZMB, ALK, MCL1
42oligonucleotide458.4GZMB, STAT3, MCL1, IL9, ACVRL1
43vegf458.1GZMB, ACVRL1, CXCR3, JAK3, MUC1, MCL1
44lipid458.0IL9, CCR4, JAK3, GZMB, MUC1, MCL1
45retinoic acid45 248.8MUC1, MCL1, CCR4, STAT3, GZMB, NPM1
46calcium45 51 24 1110.6MCL1, MUC1, JAK3, GZMB, NPM1, EBP
47serine457.0MCL1, JAK3, CXCR3, STAT3, ACVRL1, IL9
48tyrosine456.8GZMB, ALK, IL9, JAK3, STAT3, MCL1
49[alcl]456.6ALK, MUC1, NPM1, IL9, ACVRL1, CCR4

GO Terms for genes affiliated with Anaplastic Large Cell Lymphoma

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16Gene Ontology
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Cellular components related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.1RNF213, MUC1, CXCR3, STAT3, GZMB, NPM1
2integral component of plasma membraneGO:0058877.5ALK, ACVRL1, CCR4, CXCR3, MUC1, EBP

Biological processes related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphorylationGO:0163109.9STAT3, ALK
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.9STAT3, JAK3
3negative regulation of execution phase of apoptosisGO:19001189.8CXCR3, MCL1
4negative regulation of endothelial cell proliferationGO:0019379.3CXCR3, ACVRL1
5inflammatory responseGO:0069548.7IL9, CCR4, CXCR3
6signal transductionGO:0071658.6EBP, STAT3, ACVRL1, ALK, NPM1
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.5ACVRL1, STAT3, CXCR3, JAK3

Molecular functions related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.4CCR4, CXCR3
2protein kinase bindingGO:0199019.0NPM1, ACVRL1, STAT3
3protein bindingGO:0055157.5MUC1, JAK3, STAT3, ACVRL1, ALK, GZMB

Products for genes affiliated with Anaplastic Large Cell Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anaplastic Large Cell Lymphoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet