ALCL
MCID: ANP001
MIFTS: 61

Anaplastic Large Cell Lymphoma (ALCL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Anaplastic Large Cell Lymphoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Anaplastic large-cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma involving aberrant T-cells. It... more...

MalaCards: Anaplastic Large Cell Lymphoma, also known as ALCL, is related to hodgkin's lymphoma and leukemia. An important gene associated with Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Rho Family GTPases and Akt Signaling. The compounds [alcl] and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A mature t-cell and nk-cell neoplasm involving aberrant t-cells.

Aliases & Classifications for Anaplastic Large Cell Lymphoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
anaplastic large cell lymphoma:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

anaplastic large cell lymphoma 8 42 10 44 48 30
alcl 42 48
ki-1 positive anaplastic large cell lymphoma 48
cd30 positive anaplastic large cell lymphoma 48
ki-1+ anaplastic large cell lymphoma 60
primary systemic alcl 48


External Ids:

Disease Ontology8 DOID:0050744
MESH via Orphanet35 D017728
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet57 277637000

Related Diseases for Anaplastic Large Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases in the Anaplastic Large Cell Lymphoma family:

Anaplastic Small Cell Lymphoma

Diseases related to Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma31.4JUNB, CCR4, CCL17, IL9, GZMB, STAT3
2leukemia31.0NPM1, JAK3, STAT3, CD99, IL9, CXCR3
3cutaneous t cell lymphoma30.7CCL17, CXCR3, STAT3, TNFRSF8, CCR4, GZMB
4myeloid leukemia30.6IL9, STAT3, NPM1, JUNB, JAK3
5t-cell leukemia30.6STAT3, TNFRSF8, CCR4, IL9, JUNB
6sarcoma30.6ALK, CD99, MUC1, ACVRL1
7mycosis fungoides30.5TNFRSF8, GZMB, CCL17, CCR4, STAT3, CXCR3
8dermatitis30.5CCR4, GZMB, CXCR3, CCL17
9eosinophilia30.5IL9, CCL17, CCR4
10hepatitis30.5CD99, GZMB
11acute leukemia30.5IL9, NPM1
12breast cancer30.3BCL3, GZMB, TNFRSF8, CXCR3, STAT3, NPM1
13asthma30.3JAK3, CXCR3, GZMB, CCR4, CCL17, IL9
14lung cancer30.3ALK, NPM1, CXCR3, GZMB, CCR4, STAT3
15rheumatoid arthritis30.3JAK3, JUNB, TNFRSF8, GZMB, CCR4, CXCR3
16melanoma30.3GZMB, CXCR3, STAT3, CCR4, JUNB
17arthritis30.3STAT3, GZMB, JAK3, CXCR3
18myeloma30.3STAT3, ALK, TNFRSF8
19hepatitis c30.3CXCR3, CD99
20adenocarcinoma30.3MUC1, STAT3, JUNB
21tuberculosis30.3GZMB, CCR4, CXCR3, TNFRSF8
22pneumonia30.3MUC1, CCL17
23celiac disease30.3GZMB
24retinoblastoma30.3NPM1, JUNB, STAT3, BCL3
25breast lymphoma11.0
26pediatric lymphoma10.9
27bone lymphoma10.8
28adult lymphoma10.7
29central nervous system lymphoma10.7
30lung lymphoma10.6
31large cell carcinoma10.6
32alk-negative anaplastic large cell lymphoma10.6
33alk-positive anaplastic large cell lymphoma10.6
34breast reconstruction10.5
35gastrointestinal lymphoma10.5
36bladder lymphoma10.5
37diffuse large b-cell lymphoma10.5
38histiocytosis10.5
39hemophagocytic lymphohistiocytosis10.4
40cerebritis10.4
41cerebral lymphoma10.4
42primary cutaneous anaplastic large cell lymphoma10.4
43burn scar10.4
44burns10.4
45pancreas lymphoma10.4
46adult t-cell leukemia10.4
47liver lymphoma10.4
48acquired immunodeficiency syndrome10.4
49malignant histiocytosis10.4
50chronic myeloid leukemia10.4

Graphical network of the top 20 diseases related to Anaplastic Large Cell Lymphoma:



Diseases related to anaplastic large cell lymphoma

Clinical Features for Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Anaplastic Large Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anaplastic Large Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Anaplastic Large Cell Lymphoma

Search CenterWatch for Anaplastic Large Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Anaplastic Large Cell Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Anaplastic Large Cell Lymphoma:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Anaplastic Large Cell Lymphoma:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Anaplastic Large Cell Lymphoma

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Anatomical Context for Anaplastic Large Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Anaplastic Large Cell Lymphoma:

32
T cells, Breast, Bone, Nk cells, B cells, Skin, Bone marrow, Lung, Lymph node, Myeloid, Brain, Skeletal muscle, Colon, Liver, Pancreas, Endothelial, Spleen, Thymus, Testis, Placenta, Ovary, Smooth muscle, Spinal cord, Thyroid, Heart, Small intestine, Trachea

Animal Models for Anaplastic Large Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anaplastic Large Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0BCL3, JUNB, CCR4, CCL17, GZMB, SALL4
2MP:000539710.8TNFRSF8, GZMB, CCR4, JUNB, NPM1, JAK3
3MP:000200610.6CXCR3, NPM1, JUNB

Publications for Anaplastic Large Cell Lymphoma

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50PubMed
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Articles related to Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 832)
idTitleAuthorsYear
1
Primary anaplastic large cell lymphoma in the dura of the brain: case report and prediction of a favorable prognosis. (23923083)
2013
2
Beyond B-Cell Lymphomas: A Case of Optic Nerve Anaplastic Large Cell Lymphoma in a HIV Positive Patient. (23955686)
2013
3
Primary cutaneous sarcomatoid anaplastic large-cell lymphoma. (22157243)
2012
4
Teaching NeuroImages: CNS involvement in systemic anaplastic large-cell lymphoma. (22915182)
2012
5
Anaplastic large cell lymphoma and breast implants: a systematic review. (21358562)
2011
6
Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy (EPPER) mimicking bullous pemphigoid in a patient with anaplastic large cell lymphoma. (21524984)
2011
7
Nodal anaplastic large-cell lymphoma ALK-1- with CD30+ cutaneous lymphoproliferation treated with mistletoe: spontaneous remission or treatment response? (22052633)
2011
8
Resistance of cutaneous anaplastic large-cell lymphoma cells to apoptosis by death ligands is enhanced by CD30-mediated overexpression of c-FLIP. (19890350)
2010
9
Value of fine-needle aspiration cytology in diagnosis of Hodgkin's lymphoma and anaplastic large cell lymphoma: one centre experience. (20432736)
2010
10
Aggressive presentation of breast implant-associated ALK-1 negative anaplastic large cell lymphoma with bilateral axillary lymph node involvement. (19330656)
2009
11
Management of anaplastic large-cell lymphoma during pregnancy. (19506155)
2009
12
Anaplastic large cell lymphoma of the ovary in a pediatric patient. (19684523)
2009
13
Transmission of anaplastic large cell lymphoma via organ donation after cardiac death. (18021286)
2008
14
Aberrant expression of beta-HCG in anaplastic large cell lymphoma. (17990918)
2008
15
ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project. (18385450)
2008
16
Pathobiology of ALK+ anaplastic large-cell lymphoma. (17519389)
2007
17
Primary lymphohistiocytic variant of anaplastic large cell lymphoma of the stomach. (17339148)
2007
18
Anaplastic large cell lymphoma in leukemic transformation: successful treatment by transplantation. (17906210)
2007
19
Global proteome profiling of NPM/ALK-positive anaplastic large cell lymphoma. (17560012)
2007
20
Primary cutaneous anaplastic large cell lymphoma associated with vascular endothelial growth factor arising from a burn scar. (17938017)
2007
21
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. (18089725)
2007
22
NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma. (17537995)
2007
23
mRNA expression patterns indicate CD30 mediated activation of different apoptosis pathways in anaplastic large cell lymphoma but not in Hodgkin's lymphoma. (16198418)
2006
24
CD30+ anaplastic large cell lymphoma complicated by pyoderma gangrenosum with increased levels of serum cytokines. (16923111)
2006
25
The expression of CD30 in anaplastic large cell lymphoma is regulated by nucleophosmin-anaplastic lymphoma kinase-mediated JunB level in a cell type-specific manner. (16982741)
2006
26
Pediatric CD56+ anaplastic large cell lymphoma: a review of the literature. (17149964)
2006
27
JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma. (16140928)
2005
28
Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation. (16151469)
2005
29
Primary cutaneous anaplastic large cell lymphoma in an elderly patient with cryoglobulinaemic hepatitis C virus infection. (15491453)
2004
30
Genomic profiling of peripheral T-cell lymphoma, unspecified, and anaplastic large T-cell lymphoma delineates novel recurrent chromosomal alterations. (15111330)
2004
31
CD30-induced up-regulation of the inhibitor of apoptosis genes cIAP1 and cIAP2 in anaplastic large cell lymphoma cells. (15050749)
2004
32
Epstein-Barr virus-associated composite lymphoma composed of peripheral T-cell lymphoma and an anaplastic variant of a diffuse large B-cell type of non-Hodgkin's lymphoma and strongly expressing p53 protein. (15168595)
2004
33
Anaplastic large cell lymphoma presenting as a pleural effusion and mimicking primary effusion lymphoma. A report of 2 cases. (14526684)
2003
34
Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma. (12181047)
2002
35
Sarcomatoid variant of anaplastic large cell lymphoma with cytoplasmic ALK and alpha-smooth muscle actin expression: a mimic of inflammatory myofibroblastic tumor. (11438487)
2001
36
Differential expression of BCL-2 family proteins in ALK-positive and ALK-negative anaplastic large cell lymphoma of T/null-cell lineage. (11485911)
2001
37
Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas. (10994999)
2000
38
A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma. (10706082)
2000
39
In vitro adenoviral vector p53-mediated transduction and killing correlates with expression of coxsackie-adenovirus receptor and alpha(nu)beta5 integrin in SUDHL-1 cells derived from anaplastic large-cell lymphoma. (10656449)
2000
40
Hypocellular anaplastic large cell lymphoma mimicking inflammatory lesions of lymph nodes. (11075856)
2000
41
Anaplastic large cell lymphoma associated with SjAPgren's syndrome. (10037015)
1998
42
A case of lymphomatoid papulosis occurred simultaneously with Ki-1-positive anaplastic large cell lymphoma. (9159045)
1997
43
Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. (8916967)
1996
44
Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease. (8562933)
1996
45
Lymphomatoid papulosis associated with Ki-1-positive anaplastic large cell lymphoma. A report of two cases and a review of the literature. (7954268)
1994
46
Expression of the c-kit receptor in human lymphomas is restricted to Hodgkin's disease and CD30+ anaplastic large cell lymphomas. (7507733)
1994
47
CD26/dipeptidyl peptidase IV expression in human lymphomas is restricted to CD30-positive anaplastic large cell and a subset of T-cell non-Hodgkin's lymphomas. (8001932)
1994
48
Molecular evidence for a clonal relationship between lymphomatoid papulosis and Ki-1 positive large cell anaplastic lymphoma. (8274457)
1993
49
Ki-1 positive large cell anaplastic lymphoma: multiple bone lytic lesions and interleukin-6. (1337292)
1992
50
CD30-positive, anaplastic large-cell lymphomas that express CD15 but lack CD45. A possible diagnostic pitfall. (1359849)
1992

Genetic Variations for Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Anaplastic Large Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
51QIAGEN, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Pathways related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.1JUNB, CCR4, CCL17, TNFRSF8, JAK3, STAT3
2
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11.0ALK, JUNB, CCR4, CCL17, TNFRSF8, JAK3
3
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11.0CCR4, CCL17, TNFRSF8, JAK3, STAT3, CXCR3
4
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10.8CCR4, CCL17, JAK3, STAT3, CD99, CXCR3
5
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10.8JUNB, JAK3, STAT3, MUC1, IL9, BCL3
6
Hide members
10.8CCR4, CCL17, TNFRSF8, CXCR3, IL9, ACVRL1
7
Hide members
10.8CCL17, JAK3, STAT3, IL9, ALK
8
Hide members
10.8CCR4, CCL17, JAK3, STAT3, CXCR3
9
Hide members
10.6STAT3, JAK3, GZMB
10
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.6STAT3, JAK3, JUNB
1110.6CCR4, CCL17, CXCR3
1210.6MIR29A, STAT3

Compounds for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1[alcl]4411.5ALK, CCR4, CCL17, GZMB, TNFRSF8, NPM1
2tyrosine4411.5NPM1, TNFRSF8, GZMB, CCR4, JUNB, JAK3
3calcium44 49 11 2414.3JUNB, CCR4, CCL17, GZMB, TNFRSF8, NPM1
4paraffin4411.3CCR4, GZMB, TNFRSF8, NPM1, STAT3, MUC1
5serine4411.2GZMB, JAK3, STAT3, CXCR3, IL9, ACVRL1
6cyclosporin a44 28 5913.2JUNB, CCL17, GZMB, TNFRSF8, PPID, JAK3
7vegf4411.2GZMB, JAK3, STAT3, MUC1, CD99, CXCR3
8threonine4411.2JUNB, TNFRSF8, NPM1, JAK3, STAT3, MUC1
9retinoic acid44 2412.1IL9, MUC1, STAT3, NPM1, GZMB, CCR4
10nitric oxide44 11 2413.1CCL17, GZMB, JAK3, MUC1, CXCR3, IL9
11rantes4411.1GZMB, STAT3, CXCR3, IL9
1212-o-tetradecanoylphorbol 13-acetate4411.1GZMB, STAT3, MUC1, IL9, JUNB
13tarc4411.0CCR4, CCL17, CXCR3, IL9
14larc4411.0CXCR3, CCL17, CCR4
15thymidine44 2412.0TNFRSF8, STAT3, MUC1, CXCR3, IL9
16dexamethasone44 49 28 1114.0JUNB, CCL17, GZMB, STAT3
17tacrolimus44 49 1113.0CXCR3, PPID, GZMB, CCL17
18ccl344 2811.9CXCR3, CCL17, CCR4
19phosphotyrosine4410.9GZMB, JAK3, STAT3, ALK
20ccl444 2811.8CXCR3, CCL17, CCR4
21estrogen4410.8JAK3
22allergens4410.8CCL17, CXCR3, IL9
23ethanol44 49 11 2413.8JUNB, GZMB, STAT3, MUC1
24tamoxifen44 49 28 1113.7EBP, JUNB
25rapamycin4410.7BCL3, STAT3, NPM1, GZMB
26actinomycin d4410.7MUC1, STAT3, NPM1, JUNB
27ly2940024410.6GZMB, JAK3, STAT3, CXCR3
28oligonucleotide4410.4JUNB, GZMB, STAT3, IL9, ACVRL1

GO Terms for genes affiliated with Anaplastic Large Cell Lymphoma

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16Gene Ontology
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Cellular components related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1SALL4, TNFRSF8, NPM1, PPID, STAT3, MUC1
2integral to plasma membraneGO:00588710.6ALK, CCR4, EBP, MUC1, CD99, CXCR3

Biological processes related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594410.7BCL3, ACVRL1, STAT3, JAK3, SALL4, JUNB
2chemotaxisGO:00693510.6CXCR3, CCL17, CCR4
3inflammatory responseGO:00695410.4CCR4, CCL17, CXCR3, IL9

Products for genes affiliated with Anaplastic Large Cell Lymphoma

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  • Antibodies
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Sources for Anaplastic Large Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet