ALCL
MCID: ANP001
MIFTS: 61

Anaplastic Large Cell Lymphoma (ALCL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Anaplastic Large Cell Lymphoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Anaplastic large-cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma involving aberrant T-cells. It... more...

MalaCards: Anaplastic Large Cell Lymphoma, also known as ALCL, is related to hodgkin's lymphoma and leukemia. An important gene associated with Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Rho Family GTPases and Akt Signaling. The compounds [alcl] and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A mature t-cell and nk-cell neoplasm involving aberrant t-cells.

Aliases & Classifications for Anaplastic Large Cell Lymphoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
anaplastic large cell lymphoma:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

anaplastic large cell lymphoma 8 42 10 44 48 30
alcl 42 48
ki-1 positive anaplastic large cell lymphoma 48
cd30 positive anaplastic large cell lymphoma 48
ki-1+ anaplastic large cell lymphoma 60
primary systemic alcl 48


External Ids:

Disease Ontology8 DOID:0050744
MESH via Orphanet35 D017728
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet57 277637000

Related Diseases for Anaplastic Large Cell Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Anaplastic Large Cell Lymphoma family:

Anaplastic Small Cell Lymphoma

Diseases related to Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma31.4JUNB, CCR4, CCL17, IL9, GZMB, STAT3
2leukemia31.0NPM1, JAK3, STAT3, CD99, IL9, CXCR3
3cutaneous t cell lymphoma30.7CCL17, CXCR3, STAT3, TNFRSF8, CCR4, GZMB
4myeloid leukemia30.6IL9, STAT3, NPM1, JUNB, JAK3
5t-cell leukemia30.6STAT3, TNFRSF8, CCR4, IL9, JUNB
6sarcoma30.6ALK, CD99, MUC1, ACVRL1
7mycosis fungoides30.5TNFRSF8, GZMB, CCL17, CCR4, STAT3, CXCR3
8dermatitis30.5CCR4, GZMB, CXCR3, CCL17
9eosinophilia30.5IL9, CCL17, CCR4
10hepatitis30.5CD99, GZMB
11acute leukemia30.5IL9, NPM1
12breast cancer30.3BCL3, GZMB, TNFRSF8, CXCR3, STAT3, NPM1
13asthma30.3JAK3, CXCR3, GZMB, CCR4, CCL17, IL9
14lung cancer30.3ALK, NPM1, CXCR3, GZMB, CCR4, STAT3
15rheumatoid arthritis30.3JAK3, JUNB, TNFRSF8, GZMB, CCR4, CXCR3
16melanoma30.3GZMB, CXCR3, STAT3, CCR4, JUNB
17arthritis30.3STAT3, GZMB, JAK3, CXCR3
18myeloma30.3STAT3, ALK, TNFRSF8
19hepatitis c30.3CXCR3, CD99
20adenocarcinoma30.3MUC1, STAT3, JUNB
21tuberculosis30.3GZMB, CCR4, CXCR3, TNFRSF8
22pneumonia30.3MUC1, CCL17
23celiac disease30.3GZMB
24retinoblastoma30.3NPM1, JUNB, STAT3, BCL3
25breast lymphoma11.0
26pediatric lymphoma10.9
27bone lymphoma10.8
28adult lymphoma10.7
29central nervous system lymphoma10.7
30lung lymphoma10.6
31large cell carcinoma10.6
32alk-negative anaplastic large cell lymphoma10.6
33alk-positive anaplastic large cell lymphoma10.6
34breast reconstruction10.5
35gastrointestinal lymphoma10.5
36bladder lymphoma10.5
37diffuse large b-cell lymphoma10.5
38histiocytosis10.5
39hemophagocytic lymphohistiocytosis10.4
40cerebritis10.4
41cerebral lymphoma10.4
42primary cutaneous anaplastic large cell lymphoma10.4
43burn scar10.4
44burns10.4
45pancreas lymphoma10.4
46adult t-cell leukemia10.4
47liver lymphoma10.4
48acquired immunodeficiency syndrome10.4
49malignant histiocytosis10.4
50chronic myeloid leukemia10.4

Graphical network of the top 20 diseases related to Anaplastic Large Cell Lymphoma:



Diseases related to anaplastic large cell lymphoma

Clinical Features for Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Anaplastic Large Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anaplastic Large Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Anaplastic Large Cell Lymphoma

Search CenterWatch for Anaplastic Large Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Anaplastic Large Cell Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Anaplastic Large Cell Lymphoma:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Anaplastic Large Cell Lymphoma:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Anaplastic Large Cell Lymphoma

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Anatomical Context for Anaplastic Large Cell Lymphoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Anaplastic Large Cell Lymphoma:

32
T cells, Breast, Bone, Nk cells, B cells, Skin, Bone marrow, Lung, Lymph node, Myeloid, Brain, Skeletal muscle, Colon, Liver, Pancreas, Endothelial, Spleen, Thymus, Testis, Placenta, Ovary, Smooth muscle, Spinal cord, Thyroid, Heart, Small intestine, Trachea

Animal Models for Anaplastic Large Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anaplastic Large Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0BCL3, JUNB, CCR4, CCL17, GZMB, SALL4
2MP:000539710.8TNFRSF8, GZMB, CCR4, JUNB, NPM1, JAK3
3MP:000200610.6CXCR3, NPM1, JUNB

Publications for Anaplastic Large Cell Lymphoma

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Sources:
50PubMed
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Articles related to Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 832)
idTitleAuthorsYear
1
MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. (23801630)
2013
2
ALK-negative anaplastic large cell lymphoma primarily involving the bronchus: a case report and literature review. (24427373)
2013
3
Breast implant-associated anaplastic large cell lymphoma: a systematic review of the literature and mini-meta analysis. (23765424)
2013
4
Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma. (23814019)
2013
5
Implant-associated primary anaplastic large-cell lymphoma with simultaneous involvement of bilateral breast capsules. (24267734)
2013
6
Primary cutaneous anaplastic large-cell lymphoma - case report. (24346900)
2013
7
Granulocyte-colony stimulating factor-producing primary cutaneous anaplastic large cell lymphoma with cerebral metastasis. (22565644)
2013
8
Anaplastic large cell lymphoma as a cause of rapidly appearing subcutaneous nodules in an HIV-infected patient. (22633762)
2012
9
Clinical and laboratory characteristics of systemic anaplastic large cell lymphoma in Chinese patients. (22769020)
2012
10
Anaplastic large cell lymphoma, ALK-positive. (22440390)
2012
11
Case report: A unique pediatric case of a primary CD8 expressing ALK-1 positive anaplastic large cell lymphoma of skeletal muscle. (22497840)
2012
12
Brentuximab vedotin: its role in the treatment of anaplastic large cell and Hodgkin's lymphoma. (22536568)
2012
13
Correlation of seven biological factors (Hsp90a, p53, MDM2, Bcl-2, Bax, Cytochrome C, and Cleaved caspase3) with clinical outcomes of ALK+ anaplastic large-cell lymphoma. (22365399)
2011
14
Primary anaplastic large-cell lymphoma associated with breast implants. (21699454)
2011
15
Research progresses in the pathogenesis of anaplastic large cell lymphoma. (21627861)
2011
16
ALK-negative anaplastic large cell lymphoma mimicking a soft tissue sarcoma. (22090705)
2011
17
Adult anaplastic large cell lymphoma involving the central nervous system: a rare clinical scenario. (20838823)
2011
18
Cytogenetic analysis of pediatric anaplastic large cell lymphoma. (20658615)
2010
19
Cutaneous CD30 positive anaplastic large cell lymphoma. (20688023)
2010
20
ALK+ anaplastic large cell lymphoma with cohesive, perivascular arrangements on cytology, mimicking a soft tissue sarcoma: a report of 2 cases. (20306994)
2010
21
Primary ALK-1-negative anaplastic large cell lymphoma of the brain: case report and review of the literature. (18564100)
2009
22
Expression of ALK protein, mRNA and fusion transcripts in anaplastic large cell lymphoma. (19135051)
2009
23
Lymphohistiocytic anaplastic large cell lymphoma involving skin: a diagnostic challenge. (19091487)
2009
24
Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation. (19305144)
2009
25
Anaplastic large cell lymphoma in gingiva: case report and literature review. (18656392)
2008
26
AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features. (18519761)
2008
27
Treatment of primary cutaneous CD30+ anaplastic large-cell lymphoma with radiation therapy. (18037577)
2008
28
Anaplastic large cell lymphoma associated with a breast implant capsule: a case report and review of the literature. (18594466)
2008
29
Cytokine production by hepatic anaplastic large-cell lymphoma presenting as a rheumatic syndrome. (17363040)
2007
30
Anaplastic large cell lymphomas: a study of 75 pediatric patients. (17535098)
2007
31
Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology. (17941004)
2007
32
Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3' ALK gene insertion to chromosome 4 q22-24. (17509395)
2007
33
Anaplastic large cell lymphoma presenting with paraneoplastic pemphigus. (17213360)
2007
34
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma. (17464320)
2007
35
Downregulation of NPM-ALK by siRNA causes anaplastic large cell lymphoma cell growth inhibition and augments the anti cancer effects of chemotherapy in vitro. (17612934)
2007
36
Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells. (16763206)
2006
37
A case of T/null anaplastic large cell lymphoma arising in lung. (16995845)
2006
38
CD26, together with cell surface adenosine deaminase, is selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma. (17071493)
2006
39
Common ALK gene rearrangement in Asian CD30+ anaplastic large cell lymphoma: an immunohistochemical and fluorescence in situ hybridisation (FISH) study on paraffin-embedded tissue. (14555389)
2003
40
Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma. (14506160)
2003
41
Anaplastic large cell lymphoma: the shifting sands of diagnostic hematopathology. (11266530)
2001
42
Systemic anaplastic large-cell lymphoma: results from the non-Hodgkin's lymphoma classification project. (11391714)
2001
43
ALK expression in extranodal anaplastic large cell lymphoma favours systemic disease with (primary) nodal involvement and a good prognosis and occurs before dissemination. (10911802)
2000
44
Leukaemic expression of anaplastic large cell lymphoma with 46,XX,ins(2;5)(p23;q15q35) in a child with dihydropyrimidine dehydrogenase deficiency. (10764168)
2000
45
Primary cutaneous Ki-1(CD30) positive anaplastic large cell lymphoma in childhood. (10321635)
1999
46
The pathologic and clinical spectrum of anaplastic large cell lymphoma and correlation with ALK gene dysregulation. (9894470)
1999
47
Primary cutaneous Ki-1+ anaplastic large cell lymphoma: a morphologic, immunohistochemical and genetic study of an indolent case. (7650245)
1995
48
Large-cell anaplastic malignant CD30/Ki-1-positive T-type lymphoma, associated with STLV-1 virus (baboon malignant lymphoma model]. (7615247)
1995
49
Reverse transcriptase polymerase chain reaction for the Ki-1 anaplastic large cell lymphoma-associated t(2;5) translocation in Hodgkin's disease. (7527617)
1994
50
Interleukin-9 expression in human malignant lymphomas: unique association with Hodgkin's disease and large cell anaplastic lymphoma. (1908723)
1991

Genetic Variations for Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
51QIAGEN, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Pathways related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.1JUNB, CCR4, CCL17, TNFRSF8, JAK3, STAT3
2
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11.0ALK, JUNB, CCR4, CCL17, TNFRSF8, JAK3
3
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11.0CCR4, CCL17, TNFRSF8, JAK3, STAT3, CXCR3
4
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10.8CCR4, CCL17, JAK3, STAT3, CD99, CXCR3
5
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10.8JUNB, JAK3, STAT3, MUC1, IL9, BCL3
6
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10.8CCR4, CCL17, TNFRSF8, CXCR3, IL9, ACVRL1
7
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10.8CCL17, JAK3, STAT3, IL9, ALK
8
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10.8CCR4, CCL17, JAK3, STAT3, CXCR3
9
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10.6STAT3, JAK3, GZMB
10
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.6STAT3, JAK3, JUNB
1110.6CCR4, CCL17, CXCR3
1210.6MIR29A, STAT3

Compounds for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1[alcl]4411.5ALK, CCR4, CCL17, GZMB, TNFRSF8, NPM1
2tyrosine4411.5NPM1, TNFRSF8, GZMB, CCR4, JUNB, JAK3
3calcium44 49 11 2414.3JUNB, CCR4, CCL17, GZMB, TNFRSF8, NPM1
4paraffin4411.3CCR4, GZMB, TNFRSF8, NPM1, STAT3, MUC1
5serine4411.2GZMB, JAK3, STAT3, CXCR3, IL9, ACVRL1
6cyclosporin a44 28 5913.2JUNB, CCL17, GZMB, TNFRSF8, PPID, JAK3
7vegf4411.2GZMB, JAK3, STAT3, MUC1, CD99, CXCR3
8threonine4411.2JUNB, TNFRSF8, NPM1, JAK3, STAT3, MUC1
9retinoic acid44 2412.1IL9, MUC1, STAT3, NPM1, GZMB, CCR4
10nitric oxide44 11 2413.1CCL17, GZMB, JAK3, MUC1, CXCR3, IL9
11rantes4411.1GZMB, STAT3, CXCR3, IL9
1212-o-tetradecanoylphorbol 13-acetate4411.1GZMB, STAT3, MUC1, IL9, JUNB
13tarc4411.0CCR4, CCL17, CXCR3, IL9
14larc4411.0CXCR3, CCL17, CCR4
15thymidine44 2412.0TNFRSF8, STAT3, MUC1, CXCR3, IL9
16dexamethasone44 49 28 1114.0JUNB, CCL17, GZMB, STAT3
17tacrolimus44 49 1113.0CXCR3, PPID, GZMB, CCL17
18ccl344 2811.9CXCR3, CCL17, CCR4
19phosphotyrosine4410.9GZMB, JAK3, STAT3, ALK
20ccl444 2811.8CXCR3, CCL17, CCR4
21estrogen4410.8JAK3
22allergens4410.8CCL17, CXCR3, IL9
23ethanol44 49 11 2413.8JUNB, GZMB, STAT3, MUC1
24tamoxifen44 49 28 1113.7EBP, JUNB
25rapamycin4410.7BCL3, STAT3, NPM1, GZMB
26actinomycin d4410.7MUC1, STAT3, NPM1, JUNB
27ly2940024410.6GZMB, JAK3, STAT3, CXCR3
28oligonucleotide4410.4JUNB, GZMB, STAT3, IL9, ACVRL1

GO Terms for genes affiliated with Anaplastic Large Cell Lymphoma

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16Gene Ontology
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Cellular components related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1SALL4, TNFRSF8, NPM1, PPID, STAT3, MUC1
2integral to plasma membraneGO:00588710.6ALK, CCR4, EBP, MUC1, CD99, CXCR3

Biological processes related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594410.7BCL3, ACVRL1, STAT3, JAK3, SALL4, JUNB
2chemotaxisGO:00693510.6CXCR3, CCL17, CCR4
3inflammatory responseGO:00695410.4CCR4, CCL17, CXCR3, IL9

Products for genes affiliated with Anaplastic Large Cell Lymphoma

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  • Antibodies
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Sources for Anaplastic Large Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet