ALCL
MCID: ANP001
MIFTS: 61

Anaplastic Large Cell Lymphoma (ALCL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Anaplastic Large Cell Lymphoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Anaplastic large-cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma involving aberrant T-cells. It... more...

MalaCards: Anaplastic Large Cell Lymphoma, also known as ALCL, is related to hodgkin's lymphoma and leukemia. An important gene associated with Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Rho Family GTPases and Akt Signaling. The compounds [alcl] and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and bone, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A mature t-cell and nk-cell neoplasm involving aberrant t-cells.

Aliases & Classifications for Anaplastic Large Cell Lymphoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
anaplastic large cell lymphoma:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

anaplastic large cell lymphoma 8 42 10 44 48 30
alcl 42 48
ki-1 positive anaplastic large cell lymphoma 48
cd30 positive anaplastic large cell lymphoma 48
ki-1+ anaplastic large cell lymphoma 60
primary systemic alcl 48


External Ids:

Disease Ontology8 DOID:0050744
MESH via Orphanet35 D017728
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet57 277637000

Related Diseases for Anaplastic Large Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases in the Anaplastic Large Cell Lymphoma family:

Anaplastic Small Cell Lymphoma

Diseases related to Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma31.4JUNB, CCR4, CCL17, IL9, GZMB, STAT3
2leukemia31.0NPM1, JAK3, STAT3, CD99, IL9, CXCR3
3cutaneous t cell lymphoma30.7CCL17, CXCR3, STAT3, TNFRSF8, CCR4, GZMB
4myeloid leukemia30.6IL9, STAT3, NPM1, JUNB, JAK3
5t-cell leukemia30.6STAT3, TNFRSF8, CCR4, IL9, JUNB
6sarcoma30.6ALK, CD99, MUC1, ACVRL1
7mycosis fungoides30.5TNFRSF8, GZMB, CCL17, CCR4, STAT3, CXCR3
8dermatitis30.5CCR4, GZMB, CXCR3, CCL17
9eosinophilia30.5IL9, CCL17, CCR4
10hepatitis30.5CD99, GZMB
11acute leukemia30.5IL9, NPM1
12breast cancer30.3BCL3, GZMB, TNFRSF8, CXCR3, STAT3, NPM1
13asthma30.3JAK3, CXCR3, GZMB, CCR4, CCL17, IL9
14lung cancer30.3ALK, NPM1, CXCR3, GZMB, CCR4, STAT3
15rheumatoid arthritis30.3JAK3, JUNB, TNFRSF8, GZMB, CCR4, CXCR3
16melanoma30.3GZMB, CXCR3, STAT3, CCR4, JUNB
17arthritis30.3STAT3, GZMB, JAK3, CXCR3
18myeloma30.3STAT3, ALK, TNFRSF8
19hepatitis c30.3CXCR3, CD99
20adenocarcinoma30.3MUC1, STAT3, JUNB
21tuberculosis30.3GZMB, CCR4, CXCR3, TNFRSF8
22pneumonia30.3MUC1, CCL17
23celiac disease30.3GZMB
24retinoblastoma30.3NPM1, JUNB, STAT3, BCL3
25breast lymphoma11.0
26pediatric lymphoma10.9
27bone lymphoma10.8
28adult lymphoma10.7
29central nervous system lymphoma10.7
30lung lymphoma10.6
31large cell carcinoma10.6
32alk-negative anaplastic large cell lymphoma10.6
33alk-positive anaplastic large cell lymphoma10.6
34breast reconstruction10.5
35gastrointestinal lymphoma10.5
36bladder lymphoma10.5
37diffuse large b-cell lymphoma10.5
38histiocytosis10.5
39hemophagocytic lymphohistiocytosis10.4
40cerebritis10.4
41cerebral lymphoma10.4
42primary cutaneous anaplastic large cell lymphoma10.4
43burn scar10.4
44burns10.4
45pancreas lymphoma10.4
46adult t-cell leukemia10.4
47liver lymphoma10.4
48acquired immunodeficiency syndrome10.4
49malignant histiocytosis10.4
50chronic myeloid leukemia10.4

Graphical network of the top 20 diseases related to Anaplastic Large Cell Lymphoma:



Diseases related to anaplastic large cell lymphoma

Clinical Features for Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Anaplastic Large Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anaplastic Large Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Anaplastic Large Cell Lymphoma

Search CenterWatch for Anaplastic Large Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Anaplastic Large Cell Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Anaplastic Large Cell Lymphoma:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Anaplastic Large Cell Lymphoma:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Anaplastic Large Cell Lymphoma

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Anatomical Context for Anaplastic Large Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Anaplastic Large Cell Lymphoma:

32
T cells, Breast, Bone, Nk cells, B cells, Skin, Bone marrow, Lung, Lymph node, Brain, Myeloid, Skeletal muscle, Pancreas, Colon, Liver, Smooth muscle, Small intestine, Endothelial, Placenta, Testis, Thyroid, Heart, Thymus, Spleen, Spinal cord, Ovary, Trachea

Animal Models for Anaplastic Large Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anaplastic Large Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0BCL3, JUNB, CCR4, CCL17, GZMB, SALL4
2MP:000539710.8TNFRSF8, GZMB, CCR4, JUNB, NPM1, JAK3
3MP:000200610.6CXCR3, NPM1, JUNB

Publications for Anaplastic Large Cell Lymphoma

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Sources:
50PubMed
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Articles related to Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 832)
idTitleAuthorsYear
1
Keratosis lichenoides chronica in association with primary cutaneous anaplastic large cell lymphoma. (23228152)
2014
2
Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK-positive anaplastic large-cell lymphoma. (24297868)
2014
3
Anaplastic large cell lymphoma, ALK-negative. (22789917)
2013
4
Lymphohistiocytic and small cell pattern of anaplastic large cell lymphoma, ALK positive, arising in an 86-year-old woman. (23692425)
2013
5
Frequent expression of follicular dendritic cell markers in Hodgkin lymphoma and anaplastic large cell lymphoma. (23454725)
2013
6
Anaplastic large-cell lymphoma in a child with type I diabetes and unrecognised coeliac disease. (23082267)
2012
7
Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides. (22776000)
2012
8
A case of systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma associated with hypereosinophilia, granulomatous myositis and vasculitis. (22519739)
2012
9
ALK-positive anaplastic large cell lymphoma with TPM3-ALK translocation. (22591683)
2012
10
Primary anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma of the breast in a male patient. (22457412)
2012
11
CD8-positive primary cutaneous anaplastic large cell lymphoma presenting as multiple scrotal nodules and plaques. (21680287)
2011
12
CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma. (20955410)
2011
13
Crizotinib in anaplastic large-cell lymphoma. (21345110)
2011
14
C-MYC rearrangement may induce an aggressive phenotype in anaplastic lymphoma kinase positive anaplastic large cell lymphoma: Identification of a novel fusion gene ALO17/C-MYC. (21080342)
2011
15
ALK-positive anaplastic large cell lymphoma in a patient with chronic lymphocytic leukemia. (18794171)
2010
16
Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms. (20159827)
2010
17
Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth. (20554525)
2010
18
Intravascular ALK-positive anaplastic large-cell lymphoma mimicking inflammatory breast carcinoma. (19364961)
2009
19
Intensive chemotherapy for systemic anaplastic large cell lymphoma in children and adolescents: final results of Children's Cancer Group Study 5941. (18985718)
2009
20
Localized perineal cutaneous nodules: a case of recurrent systemic anaplastic large-cell lymphoma. (20055841)
2009
21
Primary cutaneous CD30+ anaplastic large-cell lymphoma with generalized skin involvement and involvement of one peripheral lymph node, successfully treated with low-dose oral etoposide. (19438576)
2009
22
Comment on HLH in a child with anaplastic large cell lymphoma (ALCL). (19011466)
2008
23
Anaplastic large cell lymphoma associated with parapsoriasis en plaques. (18480948)
2008
24
Primary cutaneous eosinophil-rich anaplastic large cell lymphoma: report of an unusual case and literature review. (18346406)
2008
25
Prevalence of bone marrow involvement in systemic anaplastic large cell lymphoma: are immunohistochemical studies necessary? (18602674)
2008
26
Neutrophil rich anaplastic large cell lymphoma presented as cutaneous nodules in an adolescent. (18298927)
2008
27
Anaplastic large cell lymphoma: a flow cytometric analysis of 29 cases. (17638668)
2007
28
The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling. (17690253)
2007
29
NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma. (17416736)
2007
30
A case of anaplastic large cell lymphoma-induced hemophagocytic lymphohistiocytosis in an adolescent female. (17405157)
2007
31
Assessment of t(2;5)(p23;q35) translocation and variants in pediatric ALK+ anaplastic large cell lymphoma. (15080301)
2004
32
Heterogeneity of genomic breakpoints in MSN-ALK translocations in anaplastic large cell lymphoma. (15297972)
2004
33
The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kappaB activation in anaplastic large cell lymphoma. (15093542)
2004
34
Cytologic and immunocytochemical findings of anaplastic large cell lymphoma: analysis of ten fine-needle aspiration specimens over a 9-year period. (12589644)
2003
35
Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. (12934099)
2003
36
Posttransplant CD30+ anaplastic large cell lymphoma with skin and lymph node involvement. (12835569)
2003
37
CD8-positive primary cutaneous anaplastic large cell lymphoma with a fair prognosis. (12361145)
2002
38
Primary Ki-1 positive anaplastic large cell non-Hodgkin's lymphoma of the lung. A case study and review of the literature]. (11862770)
2001
39
Anaplastic large cell lymphoma arising in bone: report of a case of the monomorphic variant with the t(2;5)(p23;q35) translocation. (10975933)
2000
40
Biochemical detection of novel anaplastic lymphoma kinase proteins in tissue sections of anaplastic large cell lymphoma. (10362790)
1999
41
Mapping of genomic t(2;5)(p23;q35) break points in patients with anaplastic large cell lymphoma by sequencing long-range PCR products. (9844824)
1998
42
Use of an anti-ALK antibody in the characterization of anaplastic large-cell lymphoma of childhood. (9187427)
1997
43
Adult T-cell leukemia/lymphoma with features of CD30-positive anaplastic large cell lymphoma--a case report. (9288638)
1997
44
Adenoviral vectors efficiently target cell lines derived from selected lymphocytic malignancies, including anaplastic large cell lymphoma and Hodgkin's disease. (9815692)
1997
45
CD30-positive anaplastic large cell lymphoma in a human T-cell lymphotropic virus-I endemic area. (7774890)
1995
46
Anaplastic large cell Ki-1 lymphoma with bone involvement: report of two cases. (7551339)
1995
47
Analysis of the t(2;5)(p23;q35) translocation by reverse transcription-polymerase chain reaction in CD30+ anaplastic large-cell lymphomas, in other non-Hodgkin's lymphomas of T-cell phenotype, and in Hodgkin's disease. (7662979)
1995
48
Analysis of adhesion molecules in Ki-1 anaplastic large-cell lymphoma. (7921411)
1994
49
High levels of p53 protein expression do not correlate with p53 gene mutations in anaplastic large cell lymphoma. (8103295)
1993
50
Immunohistochemistry of Hodgkin and non-Hodgkin lymphomas with emphasis on the diagnostic significance of the BNH9 antibody reactivity with anaplastic large cell (CD30 positive) lymphomas. (1330287)
1992

Genetic Variations for Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Anaplastic Large Cell Lymphoma

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Sources:
51QIAGEN, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Pathways related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1CCL17, JUNB, TNFRSF8, JAK3, STAT3, MUC1
2
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11.0ALK, ACVRL1, JUNB, IL9, CXCR3, STAT3
3
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11.0JAK3, STAT3, ALK, ACVRL1, TNFRSF8, CCL17
4
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10.8STAT3, CCR4, CCL17, CXCR3, CD99, JAK3
5
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10.8IL9, JUNB, BCL3, JAK3, MUC1, STAT3
6
Hide members
10.8CXCR3, TNFRSF8, ACVRL1, CCL17, CCR4, IL9
7
Hide members
10.8ALK, IL9, STAT3, JAK3, CCL17
8
Hide members
10.8STAT3, CXCR3, CCL17, CCR4, JAK3
9
Hide members
10.6JAK3, STAT3, GZMB
10
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.6JUNB, JAK3, STAT3
1110.6CXCR3, CCL17, CCR4
1210.6MIR29A, STAT3

Compounds for genes affiliated with Anaplastic Large Cell Lymphoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1[alcl]4411.5STAT3, BCL3, ACVRL1, NPM1, JAK3, TNFRSF8
2tyrosine4411.5CXCR3, MUC1, JUNB, CCR4, GZMB, TNFRSF8
3calcium44 49 11 2414.3EBP, CCR4, CXCR3, MUC1, JAK3, NPM1
4paraffin4411.3CD99, MUC1, STAT3, NPM1, TNFRSF8, GZMB
5serine4411.2ACVRL1, IL9, GZMB, JAK3, STAT3, CXCR3
6cyclosporin a44 28 5913.2STAT3, CCL17, JAK3, PPID, TNFRSF8, GZMB
7vegf4411.2GZMB, JAK3, STAT3, MUC1, CD99, ACVRL1
8threonine4411.2JUNB, TNFRSF8, NPM1, JAK3, STAT3, MUC1
9retinoic acid44 2412.1CCR4, MUC1, STAT3, JUNB, IL9, GZMB
10nitric oxide44 11 2413.1JAK3, IL9, GZMB, MUC1, CCL17, CXCR3
11rantes4411.1GZMB, STAT3, CXCR3, IL9
1212-o-tetradecanoylphorbol 13-acetate4411.1GZMB, IL9, JUNB, MUC1, STAT3
13tarc4411.0CCR4, IL9, CCL17, CXCR3
14larc4411.0CXCR3, CCR4, CCL17
15thymidine44 2412.0CXCR3, MUC1, TNFRSF8, STAT3, IL9
16dexamethasone44 49 28 1114.0STAT3, JUNB, CCL17, GZMB
17tacrolimus44 49 1113.0PPID, CXCR3, CCL17, GZMB
18ccl344 2811.9CCL17, CCR4, CXCR3
19phosphotyrosine4410.9ALK, GZMB, JAK3, STAT3
20ccl444 2811.8CCR4, CCL17, CXCR3
21estrogen4410.8JAK3
22allergens4410.8CCL17, CXCR3, IL9
23ethanol44 49 11 2413.8GZMB, MUC1, STAT3, JUNB
24tamoxifen44 49 28 1113.7JUNB, EBP
25rapamycin4410.7NPM1, GZMB, STAT3, BCL3
26actinomycin d4410.7JUNB, NPM1, STAT3, MUC1
27ly2940024410.6GZMB, CXCR3, STAT3, JAK3
28oligonucleotide4410.4JUNB, GZMB, ACVRL1, IL9, STAT3

GO Terms for genes affiliated with Anaplastic Large Cell Lymphoma

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16Gene Ontology
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Cellular components related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1GZMB, SALL4, TNFRSF8, NPM1, PPID, STAT3
2integral to plasma membraneGO:00588710.6CCR4, EBP, MUC1, CD99, CXCR3, ACVRL1

Biological processes related to Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594410.7JUNB, SALL4, JAK3, STAT3, ACVRL1, BCL3
2chemotaxisGO:00693510.6CCR4, CCL17, CXCR3
3inflammatory responseGO:00695410.4CCR4, CCL17, CXCR3, IL9

Products for genes affiliated with Anaplastic Large Cell Lymphoma

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  • Antibodies
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Sources for Anaplastic Large Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet