MCID: ANP009
MIFTS: 38

Anaplastic Oligodendroglioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Anaplastic Oligodendroglioma

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32MalaCards
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MalaCards: Anaplastic Oligodendroglioma is related to oligodendroglioma and leukemia. An important gene associated with Anaplastic Oligodendroglioma is CDKN2C (cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)), and among its related pathways are Cell Cycle and Small cell lung cancer. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and renal/urinary system.

Aliases & Classifications for Anaplastic Oligodendroglioma

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
anaplastic oligodendroglioma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

anaplastic oligodendroglioma 42 44 48 60


External Ids:

SNOMED-CT via Orphanet57 3102004

Related Diseases for Anaplastic Oligodendroglioma

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17GeneCards, 18GeneDecks
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Diseases related to Anaplastic Oligodendroglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.6PTEN, LGALS3, MGMT, PDGFRA, MDM2, KDR
2leukemia30.6CDKN2B, CDK4, CDKN2C, KDR, CDKN2A, PDGFRA
3astrocytoma30.5CDKN2B, CDKN2A, IGFBP2, EGFR, MDM2, MGMT
4brain cancer30.5EGFR, MDM2, MGMT
5acute leukemia30.3STMN1, IGFBP2, CDKN2B, CDKN2C
6meningitis30.1IGFBP2
7central neurocytoma30.1GFAP, OLIG2
8mixed glioma30.1PDGFRA, GFAP
9hydrocephalus30.1L1CAM
10non-hodgkin lymphoma30.1CDKN2C, STMN1, MDM2, CDKN2B
11medulloblastoma30.1CDK4, CDKN2B, STMN1, MGMT, PDGFRA, GFAP
12brain oligodendroglioma10.5
13spinal cord oligodendroglioma10.4
14cerebritis10.3
15childhood oligodendroglioma10.1
16arteriovenous malformation10.1
17psoriatic arthritis10.1
18ganglioglioma10.1
19gangliocytoma10.1
20cerebellar liponeurocytoma10.1
21cerebral lymphoma10.1
22arthritis10.1
23childhood leukemia10.1
24lymphoblastic leukemia10.1
25lynch syndrome10.1
26multiple sclerosis10.1
27paraplegia10.1
28williams syndrome10.1
29cholangiocarcinoma10.0LGALS3
30pituitary tumors10.0LGALS3
31uterine sarcoma10.0MDM2
32neurofibromatosis10.0PDGFRA
33multiple myeloma10.0CDKN2A
34hemangiopericytoma10.0MDM2
35paraganglioma10.0GFAP
36hepatitis10.0IGFBP2
37kidney cancer10.0EGFR
38leiomyoma10.0PDGFRA
39cholesteatoma10.0LGALS3
40neurofibroma10.0PDGFRA
41myeloma10.0CDKN2C, CDKN2B
42chondroma10.0PDGFRA
43mycosis fungoides10.0CDKN2B
44myeloid leukemia10.0CDK4, CDKN2B
45leukoplakia10.0MGMT
46biliary tract neoplasm10.0EGFR
47parathyroid adenoma10.0LGALS3, CDKN2C
48teratoma10.0GFAP
49fibrosarcoma10.0MDM2, PDGFRA
50gastrointestinal stromal tumor10.0KDR, PDGFRA

Graphical network of the top 20 diseases related to Anaplastic Oligodendroglioma:



Diseases related to anaplastic oligodendroglioma

Clinical Features for Anaplastic Oligodendroglioma

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Drugs & Therapeutics for Anaplastic Oligodendroglioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Anaplastic Oligodendroglioma

Drug clinical trials:

Search ClinicalTrials for Anaplastic Oligodendroglioma

Search NIH Clinical Center for Anaplastic Oligodendroglioma

Search CenterWatch for Anaplastic Oligodendroglioma

Genetic Tests for Anaplastic Oligodendroglioma

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Anatomical Context for Anaplastic Oligodendroglioma

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Animal Models for Anaplastic Oligodendroglioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anaplastic Oligodendroglioma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.5L1CAM
2MP:000536710.4LGALS3, EGFR
3MP:00053909.9PDGFRA, LGALS3, OLIG2, L1CAM
4MP:00053919.9EGFR, GFAP, L1CAM
5MP:00053769.6GFAP, CDKN2C, PDGFRA, MGMT, STMN1, CDK4
6MP:00053899.5L1CAM, PTEN, PDGFRA, CDKN2B, CDKN2A, EGFR
7MP:00036319.4LGALS3, L1CAM, CDK4, INA, OLIG1, OLIG2
8MP:00053889.4KDR, PTEN, LGALS3, CDKN2C, EGFR, OLIG2
9MP:00053699.4GFAP, OLIG2, CDK4, CDKN2A, STMN1, MDM2
10MP:00107719.3L1CAM, CDK4, CDKN2B, CDKN2A, CDKN2C, PTEN
11MP:00053819.2PTEN, GFAP, CDK4, CDKN2A, EGFR, MDM2
12MP:00053799.2CDK4, PDGFRA, MGMT, CDKN2A, CDKN2B, CDKN2C
13MP:00053709.2PTEN, IGFBP2, KDR, CDK4, EGFR, MDM2
14MP:00030129.1OLIG2, CDKN2B, EGFR, MDM2, MGMT, KDR
15MP:00020069.1CDKN2C, CDK4, CDKN2B, CDKN2A, PDGFRA, MGMT
16MP:00053978.8CDKN2B, CDK4, CDKN2C, KDR, PTEN, LGALS3
17MP:00053858.8PTEN, KDR, GFAP, CDKN2C, CDK4, IGFBP2
18MP:00028738.8GFAP, INA, EGFR, STMN1, PDGFRA, IGFBP2
19MP:00053878.7CDKN2A, LGALS3, PDGFRA, MDM2, EGFR, IGFBP2
20MP:00053868.6GFAP, MDM2, PTEN, KDR, OLIG2, CDKN2C
21MP:00053848.5MDM2, EGFR, CDKN2A, CDKN2B, L1CAM, CDKN2C
22MP:00053788.5CDKN2A, CDK4, OLIG1, OLIG2, CDKN2C, PTEN
23MP:00107688.1OLIG2, OLIG1, CDKN2C, CDK4, CDKN2B, CDKN2A

Publications for Anaplastic Oligodendroglioma

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Genetic Variations for Anaplastic Oligodendroglioma

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Expression for genes affiliated with Anaplastic Oligodendroglioma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Oligodendroglioma

Search GEO for disease gene expression data for Anaplastic Oligodendroglioma.

Pathways for genes affiliated with Anaplastic Oligodendroglioma

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB, 59Tocris Bioscience, 51QIAGEN, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2DBF4
210.0CDK4, CDKN2B, PTEN
3
Transcription Androgen Receptor nuclear signaling
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9.9PTEN, MDM2, EGFR
49.9PTEN, EGFR, MDM2
5
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9.9KDR, PDGFRA, EGFR
6
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9.9MDM2, IGFBP2, PTEN
7
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9.9CDKN2C, CDKN2B, MDM2, PDGFRA
8
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9.9CDKN2C, CDKN2B, CDK4, CDKN2A
9
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9.9STMN1, CDKN2B, CDK4, PDGFRA
10
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9.9L1CAM, EGFR, KDR
119.8MDM2, CDK4, CDKN2B, CDKN2A
12
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9.8CDKN2A, PTEN, CDK4, MDM2
139.8GFAP, OLIG2, OLIG1
14
Transcription P53 signaling pathway
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9.8CDKN2A, KDR, CDK4, MDM2
159.8MDM2, PTEN, CDK4, EGFR
169.8EGFR, LGALS3, CDK4, GFAP
17
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9.8EGFR, CDK4, MDM2, CDKN2A
18
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9.8EGFR, MDM2, PDGFRA, PTEN
19
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9.8EGFR, MDM2, PDGFRA, PTEN
209.8PDGFRA, MDM2, EGFR, KDR
21
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9.8PDGFRA, KDR, EGFR, MDM2
22
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9.7KDR, PDGFRA, EGFR, PTEN
23
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9.7DBF4, MDM2, CDKN2A, CDKN2C
249.7PDGFRA, CDKN2B, CDK4, CDKN2C, CDKN2A
25
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9.6CDKN2C, CDKN2A, MDM2, CDK4, MGMT
26
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9.6EGFR, KDR, MDM2, PDGFRA, PTEN
27
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9.6KDR, PDGFRA, MDM2, EGFR, PTEN
28
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9.6PTEN, EGFR, MDM2, GFAP, PDGFRA
299.4PTEN, CDKN2A, EGFR, MDM2, PDGFRA, STMN1
309.4PTEN, KDR, CDK4, MDM2, PDGFRA, EGFR
319.4EGFR, CDK4, MDM2, PTEN, PDGFRA, KDR
32
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9.4CDKN2C, MDM2, CDKN2A, CDK4, CDKN2B, DBF4
33
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9.4PTEN, MDM2, KDR, CDKN2A, EGFR, PDGFRA
349.3MDM2, PTEN, CDK4, CDKN2B, EGFR, STMN1
359.3CDKN2B, MDM2, EGFR, CDKN2A, PTEN, CDK4
369.2MGMT, PTEN, PDGFRA, MDM2, EGFR, CDKN2A
37
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8.6CDKN2A, CDKN2B, PDGFRA, MDM2, PTEN, KDR

Compounds for genes affiliated with Anaplastic Oligodendroglioma

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7GFAP
2cycloheximide4410.6IGFBP2
3serine4410.3STMN1, CDKN2B, CDKN2C, GFAP
4bcnu4410.1EGFR, MGMT, CDKN2A, GFAP
5sodium bisulfite4410.1MGMT, CDKN2B, CDKN2A
6flavopiridol44 1111.0CDK4, CDKN2A, EGFR, MDM2
7hematoxylin4410.0LGALS3, CDKN2A, GFAP, PTEN
8tgf beta14410.0CDKN2B, PTEN, KDR, CDK4, PDGFRA
9trastuzumab44 49 1112.0EGFR, MDM2, KDR, PTEN, CDK4
107,12-dimethylbenz(a)anthracene4410.0MDM2, CDKN2A, MGMT
11gefitinib44 49 1112.0CDK4, KDR, EGFR, MDM2, PTEN
12deoxyribonucleic acid4410.0IGFBP2, PTEN, CDKN2A, MGMT
13camptothecin44 59 1112.0MGMT, CDKN2A, MDM2, CDK4, KDR
14carboplatin44 49 1112.0MGMT, KDR, CDK4, EGFR, MDM2
15thymidylate4410.0MGMT, CDKN2A, EGFR, CDK4, MDM2
16mg 13244 5910.9MDM2, KDR, PTEN, CDKN2A, EGFR
17imatinib44 49 1111.9EGFR, KDR, PDGFRA, PTEN, MDM2
185-aza-2deoxycytidine449.9MGMT, MDM2, CDKN2A, CDKN2B, PTEN
19irinotecan44 49 1111.9MGMT, MDM2, EGFR, CDKN2A
20ly294002449.9IGFBP2, CDK4, MDM2, EGFR, KDR
21folate449.8KDR, PDGFRA, MGMT, IGFBP2, CDKN2A
22glyceraldehyde 3-phosphate449.8GFAP, LGALS3, STMN1, IGFBP2, MDM2
23glycogen44 2410.7PTEN, MDM2, IGFBP2, GFAP, CDK4, LGALS3
24pd 98,059449.7PTEN, GFAP, CDK4, CDKN2B, EGFR, MDM2
25progestin449.7KDR, CDK4, IGFBP2, EGFR
265-methylcytosine44 2410.7MGMT, CDKN2B, CDKN2A
275fluorouracil449.6KDR, CDK4, CDKN2A, EGFR, MDM2, MGMT
28phosphotyrosine449.6PTEN, CDK4, EGFR, PDGFRA, KDR
29dexamethasone44 49 28 1112.6MDM2, MGMT, CDK4, CDKN2A, KDR, GFAP
30rapamycin449.6PTEN, PDGFRA, KDR, EGFR, MDM2, IGFBP2
31agar449.5LGALS3, PTEN, MDM2, EGFR, CDKN2A, CDK4
32paclitaxel44 49 1111.5PTEN, KDR, GFAP, CDK4, MDM2, CDKN2A
33calcium44 49 11 2412.5STMN1, LGALS3, IGFBP2, CDK4, INA, GFAP
34doxorubicin44 49 1111.5MDM2, MGMT, STMN1, EGFR, CDKN2A, CDK4
35threonine449.5CDKN2B, STMN1, CDK4, GFAP, CDKN2C, PTEN
36genistein44 28 59 2 11 2414.4CDK4, PTEN, KDR, GFAP, CDKN2A, EGFR
37testosterone44 59 11 2412.4MDM2, EGFR, IGFBP2, CDKN2A, CDK4, GFAP
38thymidine44 2410.4GFAP, MGMT, MDM2, STMN1, IGFBP2, CDK4
39arginine449.4LGALS3, PTEN, CDK4, KDR, IGFBP2, GFAP
40phosphatidylinositol449.4IGFBP2, EGFR, MDM2, PDGFRA, KDR, PTEN
41oxygen44 2410.4LGALS3, PTEN, MDM2, CDKN2A, IGFBP2, STMN1
42cysteine449.3CDK4, MGMT, PTEN, GFAP, CDKN2A, MDM2
43oligonucleotide449.3LGALS3, PTEN, CDK4, CDKN2A, IGFBP2, STMN1
44nitric oxide44 11 2411.2MDM2, MGMT, KDR, CDKN2A, PTEN, LGALS3
45cisplatin44 49 59 1112.2PTEN, GFAP, LGALS3, CDK4, CDKN2A, EGFR
46paraffin449.2EGFR, CDKN2A, CDK4, GFAP, MDM2, KDR
47progesterone44 59 28 11 2413.1MDM2, STMN1, EGFR, IGFBP2, CDK4, GFAP
48vegf448.9IGFBP2, EGFR, LGALS3, CDKN2A, CDK4, GFAP
49tyrosine448.7L1CAM, PDGFRA, MDM2, STMN1, IGFBP2, CDKN2B
50retinoic acid44 249.3CDKN2B, OLIG2, INA, CDK4, CDKN2A, IGFBP2

GO Terms for genes affiliated with Anaplastic Oligodendroglioma

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16Gene Ontology
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Cellular components related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.4MDM2, EGFR, TRIM8, CDKN2A, CDKN2B, CDKN2C
2nucleusGO:0056347.6LGALS3, PDGFRA, MGMT, MDM2, EGFR, TRIM8

Biological processes related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1G1/S transition of mitotic cell cycleGO:00008210.4DBF4
2negative regulation of phosphorylationGO:04232610.3CDKN2C, CDKN2A, CDKN2B
3positive regulation of fibroblast proliferationGO:04814610.2PDGFRA, CDK4, EGFR
4regulation of cyclin-dependent protein serine/threonine kinase activityGO:00007910.2PTEN, CDKN2B, CDKN2C
5phosphatidylinositol-mediated signalingGO:04801510.0PTEN, EGFR, MDM2, PDGFRA
6fibroblast growth factor receptor signaling pathwayGO:00854310.0PDGFRA, MDM2, EGFR, PTEN
7Fc-epsilon receptor signaling pathwayGO:0380959.9PDGFRA, MDM2, PTEN, EGFR
8epidermal growth factor receptor signaling pathwayGO:0071739.8PTEN, MDM2, PDGFRA, EGFR
9mitotic cell cycleGO:0002789.8CDKN2C, CDK4, CDKN2A, DBF4, CDKN2B
10response to drugGO:0424939.7MGMT, MDM2, IGFBP2, CDK4
11positive regulation of cell proliferationGO:0082849.7KDR, PDGFRA, MDM2, EGFR, CDK4, PTEN
12neurotrophin TRK receptor signaling pathwayGO:0480119.7EGFR, PDGFRA, MDM2, PTEN
13innate immune responseGO:0450879.6EGFR, LGALS3, MDM2, PDGFRA, PTEN
14positive regulation of ERK1 and ERK2 cascadeGO:0703749.6EGFR, KDR, PDGFRA

Molecular functions related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.2KDR, PDGFRA
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN2C, CDKN2B, CDKN2A
3vascular endothelial growth factor-activated receptor activityGO:00502110.1KDR, PDGFRA
4transmembrane receptor protein tyrosine kinase activityGO:00471410.0KDR, EGFR, PDGFRA
5receptor signaling protein tyrosine kinase activityGO:00471610.0EGFR, KDR
6protein kinase bindingGO:0199019.8CDKN2C, CDKN2B, CDKN2A, PTEN
7integrin bindingGO:0051789.6KDR, GFAP, L1CAM

Products for genes affiliated with Anaplastic Oligodendroglioma

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  • Antibodies
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Sources for Anaplastic Oligodendroglioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet