Anaplastic Oligodendroglioma malady

MalaCards: Anaplastic Oligodendroglioma is related to oligodendroglioma and central neurocytoma. An important gene associated with Anaplastic Oligodendroglioma is OLIG1 (oligodendrocyte transcription factor 1), and among its related pathways are Breast Cancer Regulation by Stathmin1 and Development_EGFR signaling via PIP3. The compounds ly294002 and egcg have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and respiratory system.

anaplastic oligodendroglioma 30 8 32 43

Diseases related to anaplastic oligodendroglioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 359)

id	Related Disease	Score	Top Affiliating Genes
1	oligodendroglioma	33.5	CDKN2C, CDKN2B, CDKN2A, MGMT, PTEN, OLIG1
2	central neurocytoma	30.3	OLIG2, GFAP
3	diffuse astrocytoma	28.0	LGALS3, CDKN2B, CDKN2A, CDK4, MGMT, IGFBP2
4	pilocytic astrocytoma	27.4	KDR, LGALS3, CDKN2A, CDK4, MGMT, TP53
5	anaplastic astrocytoma	25.8	RB1, LGALS3, CDKN2B, CDKN2A, CDK4, MGMT
6	glioblastoma	25.4	PIK3CA, RB1, KDR, CDKN2B, CDKN2A, CDK4
7	astrocytoma	25.4	PIK3CA, RB1, KDR, LGALS3, CDK2, CDKN2B
8	medulloblastoma	24.8	PIK3CA, RB1, KDR, CDKN2C, CDKN2B, CDKN2A
9	soft tissue neoplasm	13.6	CDK4, MDM2
10	spindle cell liposarcoma	13.6	CDK4, MDM2
11	ring chromosome 7	13.6	EGFR, GFAP
12	mixed glioma	13.5	PDGFRA, GFAP
13	atypical lipomatous tumor	13.5	CDKN2A, CDK4, MDM2
14	chondroma	13.5	CDK4, MDM2, PDGFRA
15	myoma	13.4	CDKN2A, MDM2, EGFR
16	fibrosarcoma of bone	13.4	KDR, CDKN2A, PDGFRA
17	cervical adenosquamous carcinoma	13.4	KDR, PDGFRA, EGFR
18	thyroid cancer, follicular	13.4	KDR, LGALS3, PTEN
19	parathyroid adenoma	13.3	LGALS3, CDKN2C, CDKN2B, CDKN2A
20	ring chromosomes	13.3	CDK4, MDM2, EGFR, GFAP
21	brain cancer	13.3	PTEN, EGFR, STMN1
22	follicular adenoma	13.3	LGALS3, CDKN2B, PTEN
23	intraocular melanoma	13.3	CDKN2A, CDK4, MDM2
24	anaplastic ependymoma	13.3	MGMT, MDM2, PTEN, GFAP
25	lipoma	13.2	CDKN2A, CDK4, MDM2, PTEN
26	cerebrum cancer	13.2	TP53, GFAP
27	malignant peripheral nerve sheath tumor	13.2	CDKN2A, MDM2, PDGFRA, EGFR
28	retinoblastoma fa - friedreich ataxia	13.2	RB1, MDM2
29	ethmoid sinus adenocarcinoma	13.2	PIK3CA, EGFR
30	choroid plexus carcinoma	13.2	TP53, GFAP
31	penile cancer	13.2	PIK3CA, CDKN2A
32	lung cancer, somatic	13.2	PIK3CA, EGFR
33	anal squamous cell carcinoma	13.2	MDM2, TP53
34	neurofibroma	13.2	CDKN2A, PTEN, PDGFRA, EGFR
35	dysembryoplastic neuroepithelial tumor	13.2	TP53, OLIG2, GFAP
36	adult medulloblastoma	13.1	MDM2, TP53
37	embryonal sarcoma	13.1	CDK4, MDM2, TP53
38	familial melanoma	13.1	CDKN2C, CDKN2A, CDK4, MGMT, MDM2
39	alveolar rhabdomyosarcoma	13.1	RB1, CDK4, MDM2
40	multiple endocrine neoplasia	13.1	CDKN2C, CDKN2B, CDKN2A, CDK4, PTEN
41	vulva cancer	13.1	TP53, EGFR
42	female breast carcinoma	13.1	CDKN2A, CDK4, TP53
43	invasive bladder transitional cell carcinoma	13.1	TP53, EGFR
44	thyroid lymphoma	13.1	CDKN2B, CDKN2A, TP53
45	pneumothorax	13.1	KDR, ELN, GFAP
46	cardia cancer	13.1	CDKN2A, MDM2, TP53
47	oropharyngeal cancer, adult	13.1	CDKN2A, TP53, EGFR
48	photosensitive trichothiodystrophy	13.1	CDKN2B, CDKN2A, IGFBP2, GFAP
49	esophagus adenocarcinoma	13.1	CDKN2A, TP53, EGFR
50	recurrent respiratory papillomatosis	13.0	CDKN2A, TP53, EGFR

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to anaplastic oligodendroglioma:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.8	CDKN2C, CDKN2B, SPAG16
2	respiratory system phenotype	MP:0005388	9.7	ELN, OLIG2
3	normal phenotype	MP:0002873	9.5	STMN1, GFAP, PDGFRA, INA, KDR
4	liver/biliary system phenotype	MP:0005370	9.5	TP53, EGFR
5	hematopoietic system phenotype	MP:0005397	9.4	CDKN2C, LGALS3, CDKN2B, CDK4, MDM2, PDGFRA
6	embryogenesis phenotype	MP:0005380	9.1	PDGFRA, MDM2, CDK4, PIK3CA, EGFR, DMBT1
7	reproductive system phenotype	MP:0005389	8.9	PDGFRA, CDKN2B, CDKN2C, L1CAM, PIK3CA, SPAG16
8	nervous system phenotype	MP:0003631	8.7	CDKN2C, RB1, PTEN, OLIG2, EGFR, PDGFRA
9	no phenotypic analysis	MP:0003012	8.4	MGMT, EGFR, OLIG2, TP53, L1CAM, RB1
10	pigmentation phenotype	MP:0001186	8.0	CDKN2A, RB1, L1CAM, EGFR, PDGFRA, PTEN
11	renal/urinary system phenotype	MP:0005367	7.9	PDGFRA, LGALS3, CDKN2C, MDM2, EGFR, DMBT1
12	behavior/neurological phenotype	MP:0005386	7.6	OLIG2, PDGFRA, CDKN2C, L1CAM, RB1, KDR
13	skeleton phenotype	MP:0005390	7.4	TP53, LGALS3, PTEN, OLIG2, EGFR, MDM2
14	digestive/alimentary phenotype	MP:0005381	7.2	CDK4, MDM2, PTEN, DMBT1, PDGFRA, EGFR
15	vision/eye phenotype	MP:0005391	6.8	CDKN2A, GFAP, RB1, KDR, L1CAM, CDK2
16	integument phenotype	MP:0010771	6.7	CDKN2A, CDKN2B, CDK2, KDR, CDKN2C, RB1
17	mortality/aging	MP:0010768	6.5	PTEN, DMBT1, OLIG1, PDGFRA, EGFR, GFAP
18	muscle phenotype	MP:0005369	6.3	STMN1, PIK3CA, RB1, KDR, CDK2, CDKN2A
19	cardiovascular system phenotype	MP:0005385	6.2	IGFBP2, PTEN, TP53, PDGFRA, EGFR, STMN1
20	growth/size phenotype	MP:0005378	6.1	TP53, PTEN, OLIG2, PDGFRA, GFAP, MDM2
21	tumorigenesis	MP:0002006	6.1	MGMT, PTEN, EGFR, PDGFRA, OLIG2, DMBT1
22	immune system phenotype	MP:0005387	6.0	RB1, KDR, PIK3CA, PTEN, LGALS3, CDKN2C
23	homeostasis/metabolism phenotype	MP:0005376	5.3	TP53, PIK3CA, RB1, KDR, LGALS3, CDKN2C
24	cellular phenotype	MP:0005384	5.1	EGFR, PDGFRA, SPAG16, OLIG2, TP53, DMBT1

Articles related to anaplastic oligodendroglioma:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	Occurrence of anaplastic oligodendroglioma in a patie nt with Williams syndrome: a case report with analysis of mutational profile of tumor. (19764675)	Omalu B.I.... Nnebe-Agumadu U.H.	2009	ELN
2	Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomas. (18544654)	Idbaih A.... Delattre J.Y.	2008	EGFR
3	Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. (18492260)	Ducray F.... Sanson M.	2008	EGFR, CDK2, L1CAM
4	Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma. Case report. (17639893)	Kanamori M.... Tominaga T.	2007	TP53
5	Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma. (15470710)	Perry A.... Burger P.C.	2004	EGFR
6	Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. (15289301)	Broderick D.K.... Yan H.	2004	PTEN, PIK3CA
7	Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)	Neder L.... Zago M.A.	2004	LGALS3
8	Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas. (11764090)	Watanabe T.... Ohgaki H.	2001	CDK4, TP53, MDM2
9	PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. (11438483)	Sasaki H.... Louis D.N.	2001	PTEN, DMBT1
10	Homozygous deletions of the CDKN2C/p18INK4C gene on the short arm of chromosome 1 in anaplastic oligodendrogliomas. (10517502)	Pohl U.... Louis D.N.	1999	CDKN2C
11	Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. (9776413)	Cairncross J.G.... Louis D.N.	1998	CDKN2A

Genes related to anaplastic oligodendroglioma according to GeneCards:

(show all 29)

id	Symbol	Description	Score	GeneCards Section Context
1	OLIG1	oligodendrocyte transcription factor 1	11.0
2	OLIG2	oligodendrocyte lineage transcription factor 2	11.0	Publications
3	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	11.0	Publications
4	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
5	STMN1	stathmin 1	11.0
6	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
7	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0
8	GFAP	glial fibrillary acidic protein	11.0
9	PTEN	phosphatase and tensin homolog	11.0	Publications
10	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
11	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0
12	CDK4	cyclin-dependent kinase 4	11.0	Publications
13	MGMT	O-6-methylguanine-DNA methyltransferase	11.0
14	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0
15	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
16	EGFR	epidermal growth factor receptor	11.0	Publications
17	TRIM8	tripartite motif containing 8	11.0
18	INA	internexin neuronal intermediate filament protein, alpha	11.0	Publications
19	DBF4	DBF4 homolog (S. cerevisiae)	11.0
20	DMBT1	deleted in malignant brain tumors 1	11.0	Publications
21	L1CAM	L1 cell adhesion molecule	11.0	Publications
22	IQGAP1	IQ motif containing GTPase activating protein 1	11.0	Publications
23	ELN	elastin	11.0	Publications
24	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0	Publications
25	CDK2	cyclin-dependent kinase 2	11.0	Publications
26	RB1	retinoblastoma 1	11.0	Publications
27	SPAG16	sperm associated antigen 16	11.0
28	TP53	tumor protein p53	11.0	Publications
29	ERC2	ELKS/RAB6-interacting/CAST family member 2	11.0

Pathways related to anaplastic oligodendroglioma according to GeneDecks:

(show top 50)    (show all 59)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.5	EGFR
2	Development_EGFR signaling via PIP341	10.5	PTEN
3	Signal transduction PTEN pathway10	10.3	PIK3CA, PTEN
4	Pathway_PA16598005034	10.1	PDGFRA, EGFR, KDR
5	DNA damage ATM/ATR regulation of G1/S checkpoint10	10.0	MDM2, CDK2, CDK4
6	Development EGFR signaling via PIP310	9.8	PIK3CA, PTEN, EGFR
7	Translation_Non-genomic (rapid) action of Androgen Receptor41	9.8	PIK3CA, MDM2, PTEN, EGFR
8	Translation Non-genomic (rapid) action of Androgen Receptor10	9.7	EGFR, MDM2, PIK3CA, PTEN
9	Cell cycle Regulation of G1/S transition (part 1)10	9.7	CDK4, CDKN2A, CDKN2B, CDK2
10	Cell cycle_Regulation of G1/S transition (part 1)41	9.7	CDK4, CDK2, CDKN2A, CDKN2B
11	Focal adhesion20	9.5	PTEN, KDR, PDGFRA, PIK3CA, EGFR
12	Cell cycle Cell cycle (generic schema)10	9.5	RB1, CDK4, CDK2
13	Cell cycle_Cell cycle (generic schema)41	9.5	RB1, CDK2, CDK4
14	p53 Signaling36	9.5	TP53, CDK4, MDM2, PTEN
15	Cell cycle_Regulation of G1/S transition (part 2)41	9.4	CDK2, CDK4, RB1
16	Transcription P53 signaling pathway10	9.4	CDKN2A, CDK2, TP53
17	Cell Cycle Control by BTG Proteins36	9.4	CDK2, RB1, CDK4
18	Cell cycle Regulation of G1/S transition (part 2)10	9.3	CDK4, CDK2, RB1
19	Cell cycle ESR1 regulation of G1/S transition10	9.3	CDK2, RB1, CDK4
20	Signal transduction_AKT signaling41	9.2	TP53, MDM2, PIK3CA, PTEN
21	Endometrial cancer20	9.2	EGFR, TP53, PIK3CA, PTEN
22	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.2	TP53, MDM2, CDK4, CDK2
23	Cell Cycle, Mitotic38	9.2	DBF4, CDKN2A, CDK2, CDKN2C, RB1
24	Selected targets of p5310	9.1	CDK4, TP53, MGMT, CDK2
25	Rho Family GTPases36	9.1	IQGAP1, PDGFRA, EGFR, GFAP, KDR, ELN
26	Inhibition of Ribosome Biogenesis by p14(ARF)36	9.1	TP53, MDM2, CDKN2A, RB1
27	p53 Mediated Apoptosis36	9.0	PTEN, EGFR, PDGFRA, TP53, MDM2, KDR
28	Mitochondrial Apoptosis36	9.0	KDR, CDKN2A, TP53, EGFR, PDGFRA, MDM2
29	Cellular Apoptosis Pathway36	9.0	PDGFRA, MDM2, CDKN2A, EGFR, KDR, TP53
30	Calpain Protease Regulates Cellular Mechanics36	9.0	EGFR, CDK2, RB1, CDK4
31	Telomerase Components in Cell Signaling36	8.8	PDGFRA, RB1, KDR, TP53, EGFR
32	p53 signaling pathway20	8.8	PTEN, TP53, CDK4, CDK2, MDM2, CDKN2A
33	GADD45 Pathway36	8.7	CDK4, TP53, CDK2
34	Bladder cancer20	8.7	TP53, EGFR, CDK4, CDKN2A, MDM2, RB1
35	PTEN Pathway36	8.7	ELN, EGFR, PDGFRA, PTEN, TP53, MDM2
36	Chronic myeloid leukemia20	8.5	MDM2, CDK4, CDKN2A, TP53, RB1, PIK3CA
37	Non-small cell lung cancer20	8.5	TP53, CDK4, CDKN2A, RB1, PIK3CA, EGFR
38	Transcription_P53 signaling pathway41	8.5	TP53, RB1, KDR, CDK2, CDKN2A, MDM2
39	G1-S Phase Transition36	8.3	CDK4, CDKN2B, CDKN2A, CDKN2C, RB1, CDK2
40	Cyclins and Cell Cycle Regulation36	8.3	CDKN2C, RB1, TP53, CDKN2B, CDK4, CDKN2A
41	Small cell lung cancer20	8.1	PTEN, RB1, PIK3CA, CDKN2B, CDK4, CDK2
42	Glioma20	8.0	MDM2, CDK4, EGFR, PIK3CA, RB1, CDKN2A
43	Melanoma20	8.0	MDM2, CDK4, CDKN2A, RB1, PIK3CA, TP53
44	Glioblastoma Multiforme36	7.9	CDK2, RB1, CDK4, MGMT, MDM2, TP53
45	Cell Cycle / Checkpoint Control3	7.9	CDK4, CDKN2A, CDKN2B, CDK2, CDKN2C, MGMT
46	Prostate cancer20	7.9	MDM2, RB1, TP53, PDGFRA, EGFR, PTEN
47	Cell cycle20	7.9	CDK4, MDM2, CDKN2A, DBF4, TP53, CDKN2B
48	Pancreatic Adenocarcinoma36	7.5	KDR, CDKN2C, CDK2, TP53, PDGFRA, CDKN2B
49	Pathways in cancer20	7.5	CDK2, CDKN2B, CDK4, TP53, MDM2, PIK3CA
50	Molecular Mechanisms of Cancer36	7.3	EGFR, PDGFRA, PTEN, TP53, MDM2, CDK4

Compounds related to anaplastic oligodendroglioma according to GeneDecks:

(show top 50)    (show all 153)

id	Compound	Score	Top Affiliating Genes
1	ly29400232	10.5	PIK3CA
2	egcg32	10.4	CDK2
3	threonine32	10.3	CDKN2C, STMN1, CDKN2B
4	vincristine32 34 9 9	13.3	MGMT
5	h2o232	10.2	ELN, LGALS3
6	fascaplysin32	9.3	CDK2, CDKN2A, CDK4
7	bcnu32	9.1	MGMT, TP53, EGFR, CDKN2A, GFAP
8	estrogen32	9.1	IGFBP2, MGMT, KDR, LGALS3, PDGFRA, EGFR
9	trastuzumab32 34 9 9	12.0	CDK4, CDK2, EGFR, PTEN, KDR, MDM2
10	tgf beta132	9.0	KDR, CDKN2B, CDK4, PTEN, PDGFRA, ELN
11	gefitinib32 34 9 9	12.0	EGFR, PTEN, MDM2, CDK4, CDK2, KDR
12	arginine32	8.9	IGFBP2, PIK3CA, CDK2, CDK4, MDM2, ELN
13	imatinib32 34 9 9	11.9	PIK3CA, KDR, PDGFRA, PTEN, EGFR, MDM2
14	cysteine32	8.8	PTEN, DMBT1, MDM2, CDKN2A, LGALS3, KDR
15	agar32	8.7	CDK4, RB1, PIK3CA, CDK2, CDKN2A, ELN
16	olomoucine32 42 9 9	11.6	TP53, CDK4, CDK2, CDKN2A, RB1
17	glycogen32 18	9.6	CDK4, PIK3CA, LGALS3, CDK2, GFAP, MDM2
18	rapamycin32 42	9.5	CDK2, CDK4, RB1, KDR, MDM2, ELN
19	geldanamycin32 9 9	10.5	TP53, CDK2, MDM2, EGFR, KDR, CDK4
20	crcs32	8.5	PTEN, MGMT, TP53, CDKN2A, RB1, PIK3CA
21	carboplatin32 34 9 9	11.5	CDK4, KDR, EGFR, TP53, RB1, MGMT
22	mg 13232 42	9.4	MDM2, CDKN2A, CDK2, PTEN, EGFR, TP53
23	oxygen32 18	9.3	GFAP, LGALS3, CDK4, PTEN, IGFBP2, CDK2
24	cytarabine32 34 9 9	11.2	RB1, CDKN2B, CDKN2A, TP53, GFAP, CDK2
25	flavopiridol32 9 9	10.2	MDM2, EGFR, CDK4, CDKN2A, TP53, CDK2
26	phosphatidylinositol32	8.2	MDM2, KDR, RB1, PIK3CA, CDK2, EGFR
27	arsenite32 18	9.2	PIK3CA, MDM2, PTEN, CDKN2B, CDK2, TP53
28	pd 98,05932	8.2	PIK3CA, RB1, CDK2, PTEN, CDKN2B, STMN1
29	camptothecin32 42 9 9	11.0	MDM2, MGMT, CDK4, CDK2, CDKN2A, TP53
30	thymidylate32	8.0	MDM2, MGMT, TP53, RB1, CDK2, CDKN2A
31	adpribose32	8.0	EGFR, TP53, MDM2, CDK4, CDK2, RB1
32	etoposide32 42 9 9	10.8	PTEN, PIK3CA, RB1, LGALS3, CDK2, MGMT
33	oligonucleotide32	7.8	PTEN, TP53, IGFBP2, LGALS3, PDGFRA, STMN1
34	resveratrol32 9 18 9	10.8	TP53, PIK3CA, RB1, CDK4, MDM2, CDK2
35	cycloheximide32	7.8	CDK2, PTEN, EGFR, TP53, IGFBP2, GFAP
36	testosterone32 9 18 9	10.7	ELN, EGFR, PTEN, RB1, GFAP, CDKN2A
37	dexamethasone32 42 34 9 9	11.7	KDR, GFAP, ELN, CDKN2A, RB1, MDM2
38	vegf32	7.6	CDK2, LGALS3, KDR, PIK3CA, MGMT, MDM2
39	calcium32 9 18 9	10.6	ELN, RB1, CDK2, DMBT1, PTEN, IGFBP2
40	genistein32 9 18 9	10.5	EGFR, MDM2, ELN, GFAP, MGMT, CDK4
41	5fluorouracil32	7.2	EGFR, PTEN, TP53, MDM2, PIK3CA, RB1
42	paraffin32	7.2	EGFR, ELN, GFAP, PDGFRA, PTEN, RB1
43	thymidine32 18	8.2	TP53, PIK3CA, RB1, KDR, STMN1, GFAP
44	doxorubicin32 34 9 9	10.1	CDK2, STMN1, EGFR, PTEN, TP53, MDM2
45	paclitaxel32 34 9 9	9.9	STMN1, GFAP, EGFR, PTEN, TP53, MGMT
46	retinoic acid32 42 18	8.9	OLIG2, PDGFRA, ELN, GFAP, STMN1, IGFBP2
47	progesterone32 42 9 18 9	10.8	STMN1, RB1, GFAP, PTEN, LGALS3, CDK2
48	tyrosine32	6.8	KDR, RB1, PIK3CA, LGALS3, L1CAM, EGFR
49	cisplatin32 34 9 9	9.8	PIK3CA, RB1, PTEN, KDR, LGALS3, CDK2
50	serine32	5.4	CDKN2A, CDK4, IQGAP1, MDM2, IGFBP2, TP53

Cellular components related to anaplastic oligodendroglioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear body	GO:016604	9.1	CDKN2A, MDM2, TP53
2	PML body	GO:016605	8.7	TP53, TRIM8, RB1, PTEN
3	cytosol	GO:005829	7.3	STMN1, GFAP, PTEN, TP53, MDM2, CDK4
4	nucleoplasm	GO:005654	7.3	CDK4, MDM2, MGMT, TP53, DBF4, RB1
5	cytoplasm	GO:005737	6.0	IQGAP1, MDM2, ERC2, TRIM8, TP53, PTEN
6	nucleus	GO:005634	5.8	RB1, EGFR, PDGFRA, OLIG2, OLIG1, PTEN

Biological processes related to anaplastic oligodendroglioma according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of phosphorylation	GO:042326	10.2	CDKN2A, CDKN2B, CDKN2C
2	positive regulation of fibroblast proliferation	GO:048146	10.0	EGFR, CDK4, PDGFRA
3	phosphatidylinositol-mediated signaling	GO:048015	9.7	PIK3CA, MDM2, PDGFRA, PTEN
4	traversing start control point of mitotic cell cycle	GO:007089	9.7	MDM2, CDK2
5	negative regulation of epithelial cell proliferation	GO:050680	9.7	PTEN, RB1, CDKN2B
6	regulation of cyclin-dependent protein kinase activity	GO:000079	9.7	PTEN, CDKN2B, CDKN2C
7	G1 phase of mitotic cell cycle	GO:000080	9.5	RB1, CDKN2B, CDKN2A, CDK4, CDKN2C
8	epidermal growth factor receptor signaling pathway	GO:007173	9.5	PIK3CA, MDM2, PTEN, EGFR
9	mitotic cell cycle G1/S transition DNA damage checkpoint	GO:031571	9.2	CDK2, TP53
10	positive regulation of cell proliferation	GO:008284	9.1	EGFR, KDR, CDK2, CDK4, MDM2, PTEN
11	G1/S transition of mitotic cell cycle	GO:000082	8.9	CDKN2A, CDK4, DBF4, CDK2, CDKN2C, RB1
12	negative regulation of cell growth	GO:030308	8.9	RB1, TP53, CDKN2C, CDKN2A
13	negative regulation of apoptotic process	GO:043066	8.9	PTEN, TP53, MDM2, KDR, EGFR
14	cell cycle arrest	GO:007050	8.8	CDKN2A, CDKN2B, RB1, CDKN2C, TP53
15	mitotic cell cycle	GO:000278	8.7	DBF4, CDK4, CDKN2A, CDKN2B, CDK2, CDKN2C
16	Ras protein signal transduction	GO:007265	8.7	CDK2, RB1, CDKN2A, TP53
17	virus-host interaction	GO:019048	8.5	PDGFRA, RB1, KDR, MDM2, TP53, DMBT1
18	cell cycle checkpoint	GO:000075	8.3	TP53, MDM2, CDKN2A, CDK2, RB1, DBF4

Molecular functions related to anaplastic oligodendroglioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.0	CDKN2C, CDKN2B, CDKN2A
2	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.8	EGFR, PDGFRA, KDR
3	vascular endothelial growth factor binding	GO:038085	9.8	KDR, PDGFRA
4	protein kinase binding	GO:019901	8.6	IQGAP1, TP53, CDKN2C, CDKN2B, PTEN, CDKN2A
5	protein binding	GO:005515	4.7	EGFR, PDGFRA, DMBT1, PTEN, TP53, ERC2