MCID: ANP009
MIFTS: 43

Anaplastic Oligodendroglioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Anaplastic Oligodendroglioma

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34MalaCards
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MalaCards: Anaplastic Oligodendroglioma is related to oligodendroglioma and leukemia. An important gene associated with Anaplastic Oligodendroglioma is CDKN2C (cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and Small cell lung cancer. The compounds doxycycline and dutp have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Anaplastic Oligodendroglioma

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44NIH Rare Diseases, 46Novoseek, 50Orphanet, 63UMLS, 64UMLS via Orphanet, 60SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
anaplastic oligodendroglioma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

anaplastic oligodendroglioma 44 46 50 63


External Ids:

UMLS via Orphanet64 C0334590
SNOMED-CT via Orphanet60 3102004

Related Diseases for Anaplastic Oligodendroglioma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Anaplastic Oligodendroglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.7CDKN2B, CDKN2C, GFAP
2leukemia30.5STMN1, CDKN2B, CDK4, CDKN2C
3astrocytoma30.5LGALS3, CDK4, CDKN2B, GFAP
4brain cancer30.4CDK4, CDKN2B, GFAP
5acute leukemia30.2CDKN2C, CDKN2B, STMN1
6pilocytic astrocytoma30.1GFAP, CDK4, LGALS3
7medulloblastoma30.1GFAP, STMN1, CDK4, CDKN2B
8anaplastic astrocytoma30.1GFAP, CDK4, CDKN2B, LGALS3
9oligoastrocytoma10.6
10cerebritis10.3
11ganglioglioma10.1
12gangliocytoma10.1
13cerebellar liponeurocytoma10.1
14arteriovenous malformation10.1
15cerebral lymphoma10.1
16psoriatic arthritis10.1
17central neurocytoma10.1
18arthritis10.1
19hydrocephalus10.1
20lymphoblastic leukemia10.1
21lynch syndrome10.1
22meningitis10.1
23mixed glioma10.1
24multiple sclerosis10.1
25paraplegia10.1
26williams syndrome10.1
27cerebral cavernous malformation10.1
28diffuse astrocytoma10.1
29thunderclap headache10.1
30cavernous malformation10.1
31headache10.1
32encephalitis10.1GFAP
33burkitt's lymphoma10.1CDKN2B, CDKN2C
34plasmacytoma10.0CDKN2B, STMN1
35ependymoma10.0CDKN2B, GFAP
36parathyroid adenoma10.0LGALS3, CDKN2C
37follicular adenoma10.0LGALS3, CDKN2B
38chordoma10.0LGALS3, GFAP
39myelodysplastic syndromes10.0CDKN2B, CDKN2C
40hematologic cancer10.0CDKN2B, STMN1
41malignant peripheral nerve sheath tumor10.0CDK4, CDKN2B
42meningioma10.0CDKN2B, CDKN2C, GFAP
43gliosarcoma10.0CDK4, GFAP
44malignant mesothelioma10.0CDKN2B, CDK4
45non-hodgkin lymphoma10.0STMN1, CDKN2C, CDKN2B
46acute lymphoblastic leukemia, childhood10.0CDKN2B, CDK4
47esophageal cancer10.0CDKN2B, CDK4
48precursor t-cell acute lymphoblastic leukemia10.0CDKN2B, CDK4
49hodgkin's lymphoma10.0STMN1, CDKN2C
50chronic lymphocytic leukemia10.0CDKN2B, CDK4

Graphical network of the top 20 diseases related to Anaplastic Oligodendroglioma:



Diseases related to anaplastic oligodendroglioma

Symptoms for Anaplastic Oligodendroglioma

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Drugs & Therapeutics for Anaplastic Oligodendroglioma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Anaplastic Oligodendroglioma

Drug clinical trials:

Search ClinicalTrials for Anaplastic Oligodendroglioma

Search NIH Clinical Center for Anaplastic Oligodendroglioma

Search CenterWatch for Anaplastic Oligodendroglioma

Genetic Tests for Anaplastic Oligodendroglioma

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Anatomical Context for Anaplastic Oligodendroglioma

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34MalaCards
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MalaCards organs/tissues related to Anaplastic Oligodendroglioma:

34
Brain, Spinal cord, Bone, Bone marrow, Tongue, Breast, B cells

Animal Models for Anaplastic Oligodendroglioma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Anaplastic Oligodendroglioma:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5CDKN2B, CDK4, CDKN2C
2MP:00053678.4LGALS3, CDKN2C, CDK4, CDKN2B
3MP:00107718.2CDKN2B, CDK4, CDKN2C, LGALS3
4MP:00053898.2LGALS3, CDKN2C, CDK4, CDKN2B
5MP:00053978.2CDKN2B, CDK4, CDKN2C, LGALS3
6MP:00053877.8CDKN2B, CDK4, CDKN2C, LGALS3, GFAP
7MP:00053857.8GFAP, STMN1, LGALS3, CDKN2C, CDK4
8MP:00053847.8GFAP, LGALS3, CDKN2C, CDK4, CDKN2B
9MP:00036317.7GFAP, STMN1, LGALS3, CDKN2C, CDK4
10MP:00107687.5GFAP, LGALS3, CDKN2C, CDK4, CDKN2B
11MP:00053767.4CDKN2B, CDK4, CDKN2C, LGALS3, STMN1, GFAP

Publications for Anaplastic Oligodendroglioma

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53PubMed
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Articles related to Anaplastic Oligodendroglioma:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors. (24162809)
2014
2
Increased 99mTc TRODAT-1 Uptake in Anaplastic Oligodendroglioma. (23603602)
2014
3
Combining two biomarkers, IDH1/2 mutations and 1p/19q codeletion, to stratify anaplastic oligodendroglioma in three groups: a single-center experience. (23681562)
2013
4
Pitfalls of conservative treatments of multiple probable cerebral cavernous malformations (CCMs): clinicopathological features of CCMs coexisting with vasculogenic mimicry in an anaplastic oligodendroglioma. (24337536)
2013
5
Erratum to: Leukemia-like onset of bone marrow metastasis from anaplastic oligodendroglioma after 17A years of dormancy: an autopsy case report. (24036579)
2013
6
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. (23071247)
2013
7
Leukemia-like onset of bone marrow metastasis from anaplastic oligodendroglioma after 17A years of dormancy: an autopsy case report. (23900511)
2013
8
Feline anaplastic oligodendroglioma: long-term remission through radiation therapy and chemotherapy. (23651604)
2013
9
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951. (23071237)
2013
10
Minding the Ps and Qs: perseverance and quality studies lead to major advances in patients with anaplastic oligodendroglioma. (23071223)
2013
11
Unusual intracranial spread of anaplastic oligodendroglioma. (22891021)
2012
12
Paraplegia due to drop metastases from anaplastic oligodendroglioma. (21591854)
2012
13
Brain cancer. Fine-tuning chemoradiotherapy for anaplastic oligodendroglioma. (23149899)
2012
14
Long-term survival in a dog with anaplastic oligodendroglioma treated with radiation therapy and CCNU. (22785244)
2012
15
Breast metastasis of anaplastic oligodendroglioma: a case report. (23389376)
2012
16
Psoriatic Arthritis during Treatment with Bevacizumab for Anaplastic Oligodendroglioma. (23243547)
2012
17
Extracranial metastases of anaplastic oligodendroglioma. (20888774)
2011
18
Synchronous anaplastic oligodendroglioma and carcinoma tongue: a rare association. (20622375)
2010
19
Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomas. (18544654)
2008
20
Anaplastic oligodendroglioma with meningeal infiltration in a free-ranging red deer (Cervus elaphus). (17983625)
2008
21
Secondary anaplastic oligodendroglioma after cranial irradiation: a case report. (18373067)
2008
22
De novo formation of large arteriovenous shunting and a vascular nidus mimicking an arteriovenous malformation within an anaplastic oligodendroglioma: treatment with embolization and resection. (19035725)
2008
23
Prognostic value of health-related quality-of-life data in predicting survival in patients with anaplastic oligodendrogliomas, from a phase III EORTC brain cancer group study. (18089867)
2007
24
Panel review of anaplastic oligodendroglioma from European Organization For Research and Treatment of Cancer Trial 26951: assessment of consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome. (17549014)
2007
25
Loss of heterozygosity analysis in an anaplastic oligodendroglioma arising after radiation therapy. (17553214)
2007
26
Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma. Case report. (17639893)
2007
27
Survey of treatment recommendations for anaplastic oligodendroglioma. (17435180)
2007
28
Intracranial dissemination of primary spinal cord anaplastic oligodendroglioma. (17437621)
2007
29
Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report. (17457022)
2007
30
Anaplastic oligodendroglioma and oligoastrocytoma. (17964027)
2007
31
Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. (17145324)
2006
32
Anaplastic oligodendroglioma presenting with drop metastases in the cauda equina. (16023538)
2005
33
MR Imaging in anaplastic oligodendroglioma. (16078116)
2005
34
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. (15289301)
2004
35
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. (15372474)
2004
36
Problematic differential diagnosis between cerebellar liponeurocytoma and anaplastic oligodendroglioma. (15327238)
2004
37
Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study. (15145170)
2004
38
Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)
2004
39
Bony metastases of anaplastic oligodendroglioma respond to temozolomide. (15038479)
2004
40
Role of intraoperative smear cytology in the diagnosis of anaplastic oligodendroglioma. A case report. (12685204)
2003
41
High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma. (14686732)
2003
42
Atypical delayed intracranial haematoma following stereotactic biopsy of a right parietal anaplastic oligodendroglioma. (12860513)
2003
43
Bone marrow metastasis in anaplastic oligodendroglioma. (12800473)
2003
44
B cell non-Hodgkin cerebral lymphoma associated with an anaplastic oligodendroglioma. (12489671)
2002
45
Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas. (11764090)
2001
46
Case for the panel. Crystalline cytoplasmic inclusions in an anaplastic oligodendroglioma. (11206340)
2000
47
Combined treatment modality for anaplastic oligodendroglioma: a phase II study. (10533731)
1999
48
Intramedullary anaplastic oligodendroglioma in a child. (9579869)
1998
49
Pancytopaenia from a disseminated anaplastic oligodendroglioma. (9460719)
1997
50
Metastatic anaplastic oligodendroglioma. (2685656)
1989

Variations for Anaplastic Oligodendroglioma

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Expression for genes affiliated with Anaplastic Oligodendroglioma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anaplastic Oligodendroglioma

Search GEO for disease gene expression data for Anaplastic Oligodendroglioma.

Pathways for genes affiliated with Anaplastic Oligodendroglioma

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Sources:
51PathCards, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN
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Pathways related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.2CDKN2B, CDK4
29.2CDKN2B, CDK4
39.2CDK4, CDKN2B
49.1CDK4, STMN1
58.8CDKN2C, CDK4, CDKN2B
6
Show member pathways
8.8CDKN2B, CDK4, CDKN2C
7
Show member pathways
8.8CDKN2B, CDK4, CDKN2C
8
Show member pathways
Signaling Pathways in Glioblastoma39
8.8CDKN2B, CDK4, CDKN2C
9
Show member pathways
Cell cycle39
8.8CDKN2B, CDK4, CDKN2C
10
Show member pathways
8.8CDKN2B, CDK4, CDKN2C
11
Show member pathways
8.8CDKN2C, CDK4, CDKN2B
128.8CDKN2B, CDK4, CDKN2C
138.7STMN1, CDK4, CDKN2B
148.5GFAP, LGALS3, CDK4
15
Show member pathways
8.3CDKN2B, CDK4, CDKN2C, STMN1
16
Show member pathways
7.7GFAP, STMN1, CDKN2C, CDK4, CDKN2B

Compounds for genes affiliated with Anaplastic Oligodendroglioma

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1doxycycline46 1210.8CDKN2B, GFAP
2dutp469.6LGALS3, GFAP
3cytarabine46 52 1211.6CDKN2B, GFAP
4hematoxylin469.6GFAP, LGALS3
5phorbol 12,13-dibutyrate469.4CDK4, LGALS3
6lead469.3GFAP, CDK4
7tgf beta1469.2CDKN2B, CDK4
8glyceraldehyde 3-phosphate469.2GFAP, STMN1, LGALS3
9polyacrylamide469.2GFAP, STMN1, LGALS3
10glutamine469.1LGALS3, STMN1, GFAP
11paclitaxel46 52 1210.9GFAP, STMN1, CDK4
12thymidine46 259.9GFAP, STMN1, CDK4
13agar468.9GFAP, LGALS3, CDK4
14butyrate468.8CDK4, LGALS3, GFAP
15bromodeoxyuridine468.8CDK4, GFAP
16glycogen46 259.8CDK4, LGALS3, GFAP
17paraffin468.8GFAP, LGALS3, CDK4
18glutamate468.8LGALS3, STMN1, GFAP
19oligonucleotide468.7CDK4, LGALS3, STMN1
20vegf468.7CDK4, LGALS3, GFAP
21arginine468.7CDK4, LGALS3, GFAP
22pd 98,059468.5CDKN2B, CDK4, STMN1, GFAP
23alanine468.4GFAP, LGALS3, CDK4
24superoxide46 259.4GFAP, STMN1, LGALS3, CDK4
25cisplatin46 52 62 1211.4CDK4, LGALS3, STMN1, GFAP
26progesterone46 30 62 25 1212.4GFAP, STMN1, LGALS3, CDK4
27oxygen46 259.3CDK4, LGALS3, STMN1, GFAP
28atp46 309.3GFAP, STMN1, LGALS3, CDK4
29calcium46 52 25 1211.1GFAP, STMN1, LGALS3, CDK4
30estrogen467.9GFAP, STMN1, LGALS3, CDK4, CDKN2B
31retinoic acid46 258.9GFAP, STMN1, LGALS3, CDK4, CDKN2B
32tyrosine467.9CDKN2B, CDK4, LGALS3, STMN1, GFAP
33threonine467.5CDKN2B, CDK4, CDKN2C, LGALS3, STMN1, GFAP
34serine467.5GFAP, STMN1, LGALS3, CDKN2C, CDK4, CDKN2B

GO Terms for genes affiliated with Anaplastic Oligodendroglioma

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17Gene Ontology
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Cellular components related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.7CDKN2B, CDK4, CDKN2C, STMN1, GFAP

Biological processes related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of protein serine/threonine kinase activityGO:0719019.7CDKN2B, CDKN2C
2negative regulation of phosphorylationGO:0423269.6CDKN2B, CDKN2C
3cell cycle arrestGO:0070509.6CDKN2B, CDKN2C
4regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.3CDKN2B, CDKN2C
5mitotic cell cycleGO:0002788.7CDKN2C, CDK4, CDKN2B

Molecular functions related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CDKN2B, CDKN2C

Products for genes affiliated with Anaplastic Oligodendroglioma

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  • Antibodies
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Sources for Anaplastic Oligodendroglioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet