MCID: ANP009
MIFTS: 37

Anaplastic Oligodendroglioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Anaplastic Oligodendroglioma

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Sources:
41NIH Rare Diseases, 43Novoseek, 47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Anaplastic Oligodendroglioma, Aliases & Descriptions:

Name: Anaplastic Oligodendroglioma 41 43 47 60
Oligodendroglial Neoplasm 60
 
Oligodendroglial Tumor 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
anaplastic oligodendroglioma:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Orphanet47 251630
UMLS via Orphanet61 C0334590

Summaries for Anaplastic Oligodendroglioma

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MalaCards based summary: Anaplastic Oligodendroglioma, also known as oligodendroglial neoplasm, is related to oligodendroglioma and gliosarcoma. An important gene associated with Anaplastic Oligodendroglioma is IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and Regulation of nuclear SMAD2/3 signaling. The compounds tgf beta1 and phorbol 12,13-dibutyrate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone marrow, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Related Diseases for Anaplastic Oligodendroglioma

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Diseases related to Anaplastic Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma32.2CDKN2C, CDKN2B
2gliosarcoma30.6CDK4
3astrocytoma30.4LGALS3, CDK4, CDKN2B
4acute leukemia30.3STMN1, CDKN2C, CDKN2B
5pilocytic astrocytoma30.2LGALS3, CDK4
6medulloblastoma30.0CDK4, STMN1, CDKN2B
7glioblastoma30.0LGALS3, CDK4, IDH2, CDKN2B
8leukemia29.9CDK4, CDKN2C, STMN1, CDKN2B, IDH2
9oligoastrocytoma10.7
10cerebritis10.3
11brain cancer10.3
12anaplastic oligoastrocytoma10.3
13burkitt lymphoma10.2CDKN2B, CDKN2C
14plasmacytoma10.2CDKN2B, STMN1
15parathyroid adenoma10.2CDKN2C, LGALS3
16psoriatic arthritis10.2
17arthritis10.2
18hydrocephalus10.2
19ganglioglioma10.2
20gangliocytoma10.2
21cerebellar liponeurocytoma10.2
22arteriovenous malformation10.2
23cerebral lymphoma10.2
24central neurocytoma10.2
25lymphoblastic leukemia10.2
26lynch syndrome10.2
27meningitis10.2
28mixed glioma10.2
29paraplegia10.2
30thunderclap headache10.2
31cavernous malformation10.2
32headache10.2
33follicular adenoma10.1LGALS3, CDKN2B
34myelodysplastic syndrome10.1CDKN2C, CDKN2B
35hematologic cancer10.1CDKN2B, STMN1
36dysembryoplastic neuroepithelial tumor10.1
37adult oligodendroglioma10.1
38malignant peripheral nerve sheath tumor10.1CDK4, CDKN2B
39hodgkin lymphoma10.1STMN1, CDKN2C
40meningioma, familial10.0CDKN2B, CDKN2C
41mesothelioma, somatic10.0CDKN2B, CDK4
42acute lymphoblastic leukemia, childhood10.0CDK4, CDKN2B
43lymphoma, non-hodgkin10.0CDKN2B, CDKN2C, STMN1
44esophageal cancer10.0CDKN2B, CDK4
45precursor t-cell acute lymphoblastic leukemia10.0CDK4, CDKN2B
46glioblastoma multiforme10.0CDK4, CDKN2B
47cervical cancer, somatic9.9CDK4, CDKN2B
48lung cancer9.9CDKN2B, CDK4, CDKN2C
49malignant glioma9.8CDKN2B, CDK4, IDH2
50osteosarcoma, somatic9.8CDK4, CDKN2C, STMN1

Graphical network of the top 20 diseases related to Anaplastic Oligodendroglioma:



Diseases related to anaplastic oligodendroglioma

Symptoms for Anaplastic Oligodendroglioma

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Drugs & Therapeutics for Anaplastic Oligodendroglioma

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Drug clinical trials:

Search ClinicalTrials for Anaplastic Oligodendroglioma

Search NIH Clinical Center for Anaplastic Oligodendroglioma

Genetic Tests for Anaplastic Oligodendroglioma

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Anatomical Context for Anaplastic Oligodendroglioma

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MalaCards organs/tissues related to Anaplastic Oligodendroglioma:

31
Brain, Spinal cord, Bone marrow, Bone, Breast, B cells, Tongue

Animal Models for Anaplastic Oligodendroglioma or affiliated genes

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MGI Mouse Phenotypes related to Anaplastic Oligodendroglioma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CDKN2C, CDK4, CDKN2B
2MP:00053678.3CDKN2B, CDK4, CDKN2C, LGALS3
3MP:00107718.2CDKN2B, CDK4, CDKN2C, LGALS3
4MP:00053898.2LGALS3, CDKN2C, CDK4, CDKN2B
5MP:00053978.2CDKN2B, CDK4, CDKN2C, LGALS3
6MP:00053858.0CDK4, CDKN2C, LGALS3, STMN1
7MP:00053767.6STMN1, LGALS3, CDKN2C, CDK4, CDKN2B

Publications for Anaplastic Oligodendroglioma

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Articles related to Anaplastic Oligodendroglioma:

(show top 50)    (show all 110)
idTitleAuthorsYear
1
Efficacy and patient-reported outcomes with dose-intense temozolomide in patients with newly diagnosed pure and mixed anaplastic oligodendroglioma: a phase II multicenter study. (25534576)
2015
2
Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review. (24447608)
2014
3
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors. (24162809)
2014
4
Clinical discussion of the management of anaplastic oligodendroglioma/oligoastrocytoma (both codeleted and nondeleted). (24812135)
2014
5
Increased 99mTc TRODAT-1 Uptake in Anaplastic Oligodendroglioma. (23603602)
2014
6
Pattern of care of anaplastic oligodendroglioma and oligoastrocytoma in a Korean population: the Korean radiation oncology group study 13-12. (25391968)
2014
7
Combining two biomarkers, IDH1/2 mutations and 1p/19q codeletion, to stratify anaplastic oligodendroglioma in three groups: a single-center experience. (23681562)
2013
8
1p/19q codeletion and IDH1/2 mutation identified a subtype of anaplastic oligoastrocytomas with prognosis as favorable as anaplastic oligodendrogliomas. (23486687)
2013
9
Pitfalls of conservative treatments of multiple probable cerebral cavernous malformations (CCMs): clinicopathological features of CCMs coexisting with vasculogenic mimicry in an anaplastic oligodendroglioma. (24337536)
2013
10
Erratum to: Leukemia-like onset of bone marrow metastasis from anaplastic oligodendroglioma after 17A years of dormancy: an autopsy case report. (24036579)
2013
11
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. (23071247)
2013
12
Leukemia-like onset of bone marrow metastasis from anaplastic oligodendroglioma after 17A years of dormancy: an autopsy case report. (23900511)
2013
13
Feline anaplastic oligodendroglioma: long-term remission through radiation therapy and chemotherapy. (23651604)
2013
14
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951. (23071237)
2013
15
Temozolomide salvage chemotherapy for recurrent anaplastic oligodendroglioma and oligo-astrocytoma. (24527191)
2013
16
Minding the Ps and Qs: perseverance and quality studies lead to major advances in patients with anaplastic oligodendroglioma. (23071223)
2013
17
Unusual intracranial spread of anaplastic oligodendroglioma. (22891021)
2012
18
Paraplegia due to drop metastases from anaplastic oligodendroglioma. (21591854)
2012
19
Brain cancer. Fine-tuning chemoradiotherapy for anaplastic oligodendroglioma. (23149899)
2012
20
Long-term survival in a dog with anaplastic oligodendroglioma treated with radiation therapy and CCNU. (22785244)
2012
21
Breast metastasis of anaplastic oligodendroglioma: a case report. (23389376)
2012
22
Extracranial metastases of anaplastic oligodendroglioma. (20888774)
2011
23
Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomas. (18544654)
2008
24
Anaplastic oligodendroglioma with meningeal infiltration in a free-ranging red deer (Cervus elaphus). (17983625)
2008
25
Secondary anaplastic oligodendroglioma after cranial irradiation: a case report. (18373067)
2008
26
Prognostic value of health-related quality-of-life data in predicting survival in patients with anaplastic oligodendrogliomas, from a phase III EORTC brain cancer group study. (18089867)
2007
27
Panel review of anaplastic oligodendroglioma from European Organization For Research and Treatment of Cancer Trial 26951: assessment of consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome. (17549014)
2007
28
Loss of heterozygosity analysis in an anaplastic oligodendroglioma arising after radiation therapy. (17553214)
2007
29
Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma. Case report. (17639893)
2007
30
Survey of treatment recommendations for anaplastic oligodendroglioma. (17435180)
2007
31
Intracranial dissemination of primary spinal cord anaplastic oligodendroglioma. (17437621)
2007
32
Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report. (17457022)
2007
33
Anaplastic oligodendroglioma and oligoastrocytoma. (17964027)
2007
34
Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. (17145324)
2006
35
Anaplastic oligodendroglioma presenting with drop metastases in the cauda equina. (16023538)
2005
36
MR Imaging in anaplastic oligodendroglioma. (16078116)
2005
37
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. (15289301)
2004
38
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. (15372474)
2004
39
Problematic differential diagnosis between cerebellar liponeurocytoma and anaplastic oligodendroglioma. (15327238)
2004
40
Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study. (15145170)
2004
41
Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)
2004
42
Bony metastases of anaplastic oligodendroglioma respond to temozolomide. (15038479)
2004
43
Role of intraoperative smear cytology in the diagnosis of anaplastic oligodendroglioma. A case report. (12685204)
2003
44
High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma. (14686732)
2003
45
Atypical delayed intracranial haematoma following stereotactic biopsy of a right parietal anaplastic oligodendroglioma. (12860513)
2003
46
B cell non-Hodgkin cerebral lymphoma associated with an anaplastic oligodendroglioma. (12489671)
2002
47
Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas. (11764090)
2001
48
Combined treatment modality for anaplastic oligodendroglioma: a phase II study. (10533731)
1999
49
Pancytopaenia from a disseminated anaplastic oligodendroglioma. (9460719)
1997
50
Metastatic anaplastic oligodendroglioma. (2685656)
1989

Variations for Anaplastic Oligodendroglioma

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Expression for genes affiliated with Anaplastic Oligodendroglioma

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Search GEO for disease gene expression data for Anaplastic Oligodendroglioma.

Pathways for genes affiliated with Anaplastic Oligodendroglioma

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Pathways related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.4CDKN2B, CDK4
29.4CDKN2B, CDK4
39.4CDK4, CDKN2B
49.3CDK4, STMN1
59.1CDK4, LGALS3
6
Show member pathways
9.0CDKN2C, CDK4, CDKN2B
79.0CDKN2B, CDK4, CDKN2C
8
Show member pathways
9.0CDKN2C, CDK4, CDKN2B
9
Show member pathways
Cell cycle36
9.0CDKN2B, CDK4, CDKN2C
10
Show member pathways
9.0CDKN2C, CDK4, CDKN2B
11
Show member pathways
9.0CDKN2B, CDK4, CDKN2C
12
Show member pathways
Signaling Pathways in Glioblastoma36
9.0CDKN2C, CDK4, CDKN2B
139.0CDKN2B, CDK4, CDKN2C
148.8CDKN2B, CDK4, STMN1
15
Show member pathways
8.4CDKN2B, CDK4, CDKN2C, STMN1
16
Show member pathways
8.4STMN1, CDKN2C, CDK4, CDKN2B

Compounds for genes affiliated with Anaplastic Oligodendroglioma

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Compounds related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

(show all 12)
idCompoundScoreTop Affiliating Genes
1tgf beta1439.4CDKN2B, CDK4
2phorbol 12,13-dibutyrate439.3CDK4, LGALS3
3pd 98,059439.0STMN1, CDK4, CDKN2B
4superoxide43 249.6STMN1, LGALS3, CDK4
5cisplatin43 49 59 1211.6CDK4, LGALS3, STMN1
6progesterone43 28 59 24 1212.4CDK4, LGALS3, STMN1
7oligonucleotide438.2STMN1, LGALS3, CDK4
8estrogen438.2STMN1, LGALS3, CDK4, CDKN2B
9retinoic acid43 249.2CDKN2B, CDK4, LGALS3, STMN1
10tyrosine438.0STMN1, LGALS3, CDK4, CDKN2B
11threonine437.8CDKN2B, CDK4, CDKN2C, LGALS3, STMN1
12serine437.8STMN1, LGALS3, CDKN2C, CDK4, CDKN2B

GO Terms for genes affiliated with Anaplastic Oligodendroglioma

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Cellular components related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.4CDKN2B, CDK4, CDKN2C, STMN1

Biological processes related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of protein serine/threonine kinase activityGO:00719019.6CDKN2B, CDKN2C
2negative regulation of phosphorylationGO:00423269.6CDKN2B, CDKN2C
3G1/S transition of mitotic cell cycleGO:00000829.5CDK4, CDKN2C
4regulation of cyclin-dependent protein serine/threonine kinase activityGO:00000799.4CDKN2B, CDKN2C
5cell cycle arrestGO:00070509.2CDKN2B, CDKN2C
6mitotic cell cycleGO:00002789.0CDKN2C, CDK4, CDKN2B

Molecular functions related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.5CDKN2B, CDKN2C

Products for genes affiliated with Anaplastic Oligodendroglioma

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Sources for Anaplastic Oligodendroglioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet