MCID: ANP009
MIFTS: 43

Anaplastic Oligodendroglioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Anaplastic Oligodendroglioma

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MalaCards based summary: Anaplastic Oligodendroglioma is related to oligodendroglioma and acute leukemia. An important gene associated with Anaplastic Oligodendroglioma is CDKN2C (cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and Small cell lung cancer. The compounds doxycycline and dutp have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone marrow, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Anaplastic Oligodendroglioma

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Sources:
42NIH Rare Diseases, 44Novoseek, 48Orphanet, 62UMLS, 63UMLS via Orphanet
See all sources

Anaplastic Oligodendroglioma, Aliases & Descriptions:

Name: Anaplastic Oligodendroglioma 42 44 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
anaplastic oligodendroglioma:
Inheritance: Sporadic; Age of onset: Adulthood


External Ids:

UMLS via Orphanet63 C0334590

Related Diseases for Anaplastic Oligodendroglioma

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Diseases related to Anaplastic Oligodendroglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.8CDKN2B, CDKN2C, GFAP
2acute leukemia30.3STMN1, CDKN2C, CDKN2B
3leukemia30.2STMN1, CDKN2C, CDK4, CDKN2B
4astrocytoma30.2CDKN2B, CDK4, LGALS3, GFAP
5brain cancer30.0GFAP, CDK4, CDKN2B
6glioblastoma30.0GFAP, LGALS3, CDK4, CDKN2B
7pilocytic astrocytoma29.9CDK4, LGALS3, GFAP
8acute lymphoblastic leukemia29.8STMN1, CDKN2C, CDK4, CDKN2B
9medulloblastoma29.7GFAP, STMN1, CDK4, CDKN2B
10oligoastrocytoma10.7
11encephalitis10.3GFAP
12cerebritis10.3
13burkitt's lymphoma10.3CDKN2B, CDKN2C
14ependymoma10.2GFAP, CDKN2B
15plasmacytoma10.2STMN1, CDKN2B
16parathyroid adenoma10.2CDKN2C, LGALS3
17arthritis10.2
18hydrocephalus10.2
19multiple sclerosis10.2
20gangliocytoma10.2
21central neurocytoma10.2
22cerebellar liponeurocytoma10.2
23cerebral lymphoma10.2
24ganglioglioma10.2
25psoriatic arthritis10.2
26arteriovenous malformation10.2
27lymphoblastic leukemia10.2
28lynch syndrome10.2
29meningitis10.2
30mixed glioma10.2
31paraplegia10.2
32williams syndrome10.2
33anaplastic oligoastrocytoma10.2
34cerebral cavernous malformation10.2
35thunderclap headache10.2
36cavernous malformation10.2
37headache10.2
38follicular adenoma10.1CDKN2B, LGALS3
39chordoma10.1LGALS3, GFAP
40myelodysplastic syndromes10.1CDKN2C, CDKN2B
41hematologic cancer10.1CDKN2B, STMN1
42malignant peripheral nerve sheath tumor10.1CDKN2B, CDK4
43meningioma10.0CDKN2B, CDKN2C, GFAP
44gliosarcoma10.0CDK4, GFAP
45malignant mesothelioma10.0CDK4, CDKN2B
46non-hodgkin lymphoma10.0CDKN2B, CDKN2C, STMN1
47acute lymphoblastic leukemia, childhood10.0CDKN2B, CDK4
48esophageal cancer10.0CDK4, CDKN2B
49precursor t-cell acute lymphoblastic leukemia10.0CDKN2B, CDK4
50hodgkin's lymphoma9.9CDKN2C, STMN1

Graphical network of the top 20 diseases related to Anaplastic Oligodendroglioma:



Diseases related to anaplastic oligodendroglioma

Symptoms for Anaplastic Oligodendroglioma

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Drugs & Therapeutics for Anaplastic Oligodendroglioma

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Drug clinical trials:

Search ClinicalTrials for Anaplastic Oligodendroglioma

Search NIH Clinical Center for Anaplastic Oligodendroglioma

Genetic Tests for Anaplastic Oligodendroglioma

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Anatomical Context for Anaplastic Oligodendroglioma

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MalaCards organs/tissues related to Anaplastic Oligodendroglioma:

32
Brain, Spinal cord, Bone marrow, Bone, Breast, B cells, Tongue

Animal Models for Anaplastic Oligodendroglioma or affiliated genes

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MGI Mouse Phenotypes related to Anaplastic Oligodendroglioma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5CDKN2B, CDK4, CDKN2C
2MP:00053678.4LGALS3, CDKN2C, CDK4, CDKN2B
3MP:00107718.2CDKN2B, CDK4, CDKN2C, LGALS3
4MP:00053898.2LGALS3, CDKN2C, CDK4, CDKN2B
5MP:00053978.2CDKN2B, CDK4, CDKN2C, LGALS3
6MP:00053877.8CDKN2B, CDK4, CDKN2C, LGALS3, GFAP
7MP:00053857.8GFAP, STMN1, LGALS3, CDKN2C, CDK4
8MP:00053847.8GFAP, LGALS3, CDKN2C, CDK4, CDKN2B
9MP:00036317.7GFAP, STMN1, LGALS3, CDKN2C, CDK4
10MP:00107687.5GFAP, LGALS3, CDKN2C, CDK4, CDKN2B
11MP:00053767.4CDKN2B, CDK4, CDKN2C, LGALS3, STMN1, GFAP

Publications for Anaplastic Oligodendroglioma

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Articles related to Anaplastic Oligodendroglioma:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review. (24447608)
2014
2
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors. (24162809)
2014
3
Clinical discussion of the management of anaplastic oligodendroglioma/oligoastrocytoma (both codeleted and nondeleted). (24812135)
2014
4
Increased 99mTc TRODAT-1 Uptake in Anaplastic Oligodendroglioma. (23603602)
2014
5
Pattern of care of anaplastic oligodendroglioma and oligoastrocytoma in a Korean population: the Korean radiation oncology group study 13-12. (25391968)
2014
6
Combining two biomarkers, IDH1/2 mutations and 1p/19q codeletion, to stratify anaplastic oligodendroglioma in three groups: a single-center experience. (23681562)
2013
7
1p/19q codeletion and IDH1/2 mutation identified a subtype of anaplastic oligoastrocytomas with prognosis as favorable as anaplastic oligodendrogliomas. (23486687)
2013
8
Pitfalls of conservative treatments of multiple probable cerebral cavernous malformations (CCMs): clinicopathological features of CCMs coexisting with vasculogenic mimicry in an anaplastic oligodendroglioma. (24337536)
2013
9
Erratum to: Leukemia-like onset of bone marrow metastasis from anaplastic oligodendroglioma after 17A years of dormancy: an autopsy case report. (24036579)
2013
10
Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. (23071247)
2013
11
Leukemia-like onset of bone marrow metastasis from anaplastic oligodendroglioma after 17A years of dormancy: an autopsy case report. (23900511)
2013
12
Feline anaplastic oligodendroglioma: long-term remission through radiation therapy and chemotherapy. (23651604)
2013
13
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951. (23071237)
2013
14
Temozolomide salvage chemotherapy for recurrent anaplastic oligodendroglioma and oligo-astrocytoma. (24527191)
2013
15
Minding the Ps and Qs: perseverance and quality studies lead to major advances in patients with anaplastic oligodendroglioma. (23071223)
2013
16
Unusual intracranial spread of anaplastic oligodendroglioma. (22891021)
2012
17
Paraplegia due to drop metastases from anaplastic oligodendroglioma. (21591854)
2012
18
Brain cancer. Fine-tuning chemoradiotherapy for anaplastic oligodendroglioma. (23149899)
2012
19
Long-term survival in a dog with anaplastic oligodendroglioma treated with radiation therapy and CCNU. (22785244)
2012
20
Breast metastasis of anaplastic oligodendroglioma: a case report. (23389376)
2012
21
Psoriatic Arthritis during Treatment with Bevacizumab for Anaplastic Oligodendroglioma. (23243547)
2012
22
Extracranial metastases of anaplastic oligodendroglioma. (20888774)
2011
23
Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomas. (18544654)
2008
24
Anaplastic oligodendroglioma with meningeal infiltration in a free-ranging red deer (Cervus elaphus). (17983625)
2008
25
Secondary anaplastic oligodendroglioma after cranial irradiation: a case report. (18373067)
2008
26
Panel review of anaplastic oligodendroglioma from European Organization For Research and Treatment of Cancer Trial 26951: assessment of consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome. (17549014)
2007
27
Loss of heterozygosity analysis in an anaplastic oligodendroglioma arising after radiation therapy. (17553214)
2007
28
Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma. Case report. (17639893)
2007
29
Survey of treatment recommendations for anaplastic oligodendroglioma. (17435180)
2007
30
Intracranial dissemination of primary spinal cord anaplastic oligodendroglioma. (17437621)
2007
31
Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report. (17457022)
2007
32
Anaplastic oligodendroglioma and oligoastrocytoma. (17964027)
2007
33
Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review. (17145324)
2006
34
Anaplastic oligodendroglioma presenting with drop metastases in the cauda equina. (16023538)
2005
35
MR Imaging in anaplastic oligodendroglioma. (16078116)
2005
36
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. (15289301)
2004
37
Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study. (15372474)
2004
38
Problematic differential diagnosis between cerebellar liponeurocytoma and anaplastic oligodendroglioma. (15327238)
2004
39
Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study. (15145170)
2004
40
Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)
2004
41
Bony metastases of anaplastic oligodendroglioma respond to temozolomide. (15038479)
2004
42
Role of intraoperative smear cytology in the diagnosis of anaplastic oligodendroglioma. A case report. (12685204)
2003
43
High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma. (14686732)
2003
44
Atypical delayed intracranial haematoma following stereotactic biopsy of a right parietal anaplastic oligodendroglioma. (12860513)
2003
45
Bone marrow metastasis in anaplastic oligodendroglioma. (12800473)
2003
46
B cell non-Hodgkin cerebral lymphoma associated with an anaplastic oligodendroglioma. (12489671)
2002
47
Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas. (11764090)
2001
48
Combined treatment modality for anaplastic oligodendroglioma: a phase II study. (10533731)
1999
49
Pancytopaenia from a disseminated anaplastic oligodendroglioma. (9460719)
1997
50
Metastatic anaplastic oligodendroglioma. (2685656)
1989

Variations for Anaplastic Oligodendroglioma

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Expression for genes affiliated with Anaplastic Oligodendroglioma

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Expression patterns in normal tissues for genes affiliated with Anaplastic Oligodendroglioma

Search GEO for disease gene expression data for Anaplastic Oligodendroglioma.

Pathways for genes affiliated with Anaplastic Oligodendroglioma

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Pathways related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.2CDKN2B, CDK4
29.2CDKN2B, CDK4
39.2CDK4, CDKN2B
49.1CDK4, STMN1
58.8CDKN2C, CDK4, CDKN2B
6
Show member pathways
8.8CDKN2B, CDK4, CDKN2C
7
Show member pathways
8.8CDKN2B, CDK4, CDKN2C
8
Show member pathways
Signaling Pathways in Glioblastoma37
8.8CDKN2B, CDK4, CDKN2C
9
Show member pathways
Cell cycle37
8.8CDKN2B, CDK4, CDKN2C
10
Show member pathways
8.8CDKN2B, CDK4, CDKN2C
11
Show member pathways
8.8CDKN2C, CDK4, CDKN2B
128.8CDKN2B, CDK4, CDKN2C
138.7STMN1, CDK4, CDKN2B
148.5GFAP, LGALS3, CDK4
15
Show member pathways
8.3CDKN2B, CDK4, CDKN2C, STMN1
16
Show member pathways
7.7GFAP, STMN1, CDKN2C, CDK4, CDKN2B

Compounds for genes affiliated with Anaplastic Oligodendroglioma

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Compounds related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1doxycycline44 1110.8CDKN2B, GFAP
2dutp449.6LGALS3, GFAP
3cytarabine44 50 1111.6CDKN2B, GFAP
4hematoxylin449.6GFAP, LGALS3
5phorbol 12,13-dibutyrate449.4CDK4, LGALS3
6lead449.3GFAP, CDK4
7tgf beta1449.2CDKN2B, CDK4
8glyceraldehyde 3-phosphate449.2GFAP, STMN1, LGALS3
9polyacrylamide449.2GFAP, STMN1, LGALS3
10glutamine449.1LGALS3, STMN1, GFAP
11paclitaxel44 50 1110.9GFAP, STMN1, CDK4
12thymidine44 249.9GFAP, STMN1, CDK4
13agar448.9GFAP, LGALS3, CDK4
14butyrate448.8CDK4, LGALS3, GFAP
15bromodeoxyuridine448.8CDK4, GFAP
16glycogen44 249.8CDK4, LGALS3, GFAP
17paraffin448.8GFAP, LGALS3, CDK4
18glutamate448.8LGALS3, STMN1, GFAP
19oligonucleotide448.7CDK4, LGALS3, STMN1
20vegf448.7CDK4, LGALS3, GFAP
21arginine448.7CDK4, LGALS3, GFAP
22pd 98,059448.5CDKN2B, CDK4, STMN1, GFAP
23alanine448.4GFAP, LGALS3, CDK4
24superoxide44 249.4GFAP, STMN1, LGALS3, CDK4
25cisplatin44 50 61 1111.4CDK4, LGALS3, STMN1, GFAP
26progesterone44 28 61 24 1112.4GFAP, STMN1, LGALS3, CDK4
27oxygen44 249.3CDK4, LGALS3, STMN1, GFAP
28atp44 289.3GFAP, STMN1, LGALS3, CDK4
29calcium44 50 24 1111.1GFAP, STMN1, LGALS3, CDK4
30estrogen447.9GFAP, STMN1, LGALS3, CDK4, CDKN2B
31retinoic acid44 248.9GFAP, STMN1, LGALS3, CDK4, CDKN2B
32tyrosine447.9CDKN2B, CDK4, LGALS3, STMN1, GFAP
33threonine447.5CDKN2B, CDK4, CDKN2C, LGALS3, STMN1, GFAP
34serine447.5GFAP, STMN1, LGALS3, CDKN2C, CDK4, CDKN2B

GO Terms for genes affiliated with Anaplastic Oligodendroglioma

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Cellular components related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.7CDKN2B, CDK4, CDKN2C, STMN1, GFAP

Biological processes related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of protein serine/threonine kinase activityGO:0719019.7CDKN2B, CDKN2C
2negative regulation of phosphorylationGO:0423269.6CDKN2B, CDKN2C
3cell cycle arrestGO:0070509.6CDKN2B, CDKN2C
4regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.3CDKN2B, CDKN2C
5mitotic cell cycleGO:0002788.7CDKN2C, CDK4, CDKN2B

Molecular functions related to Anaplastic Oligodendroglioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.6CDKN2B, CDKN2C

Products for genes affiliated with Anaplastic Oligodendroglioma

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Sources for Anaplastic Oligodendroglioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet