MCID: AND009
MIFTS: 35

Androgenetic Alopecia malady

Rare diseases category
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Summaries for Androgenetic Alopecia

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NIH Rare Diseases:42 Androgenetic alopecia is a common form of hair loss in both men and women. in men, hair is usually lost in a well-defined pattern, beginning above both temples and is usually referred to as male-pattern baldness. over time, the hairline recedes to form a characteristic 'm' shape. hair also thins near the top of the head, often progressing to partial or complete baldness. the pattern of hair loss in women differs from men (female pattern hair loss). in women, the hair becomes thinner all over the head, and the hairline does not recede. androgenetic alopecia in women rarely leads to total baldness. a variety of genetic and environmental factors likely play a role in causing this condition. mutations in the ar gene have also been associated with androgenetic alopecia. last updated: 8/19/2011

MalaCards based summary: Androgenetic Alopecia, also known as androgenic alopecia, is related to alopecia and alopecia areata. An important gene associated with Androgenetic Alopecia is SPPL2C (signal peptide peptidase like 2C), and among its related pathways are Pathways in cancer and Transcription Androgen Receptor nuclear signaling. Affiliated tissues include prostate, skin and heart, and related mouse phenotype normal.

Genetics Home Reference:21 Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness.

Wikipedia:65 Androgenic alopecia (also known as androgenetic alopecia, alopecia androgenetica, male pattern baldness)... more...

Aliases & Classifications for Androgenetic Alopecia

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Androgenetic Alopecia, Aliases & Descriptions:

Name: Androgenetic Alopecia 30 42 21 62
Androgenic Alopecia 42 21 62
Female Pattern Baldness 21
Female Pattern Alopecia 62
 
Male Pattern Alopecia 21
Male Pattern Baldness 21
Alopecia Androgenetic 44
Pattern Baldness 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Androgenetic Alopecia

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Graphical network of the top 20 diseases related to Androgenetic Alopecia:



Diseases related to androgenetic alopecia

Symptoms for Androgenetic Alopecia

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Drugs & Therapeutics for Androgenetic Alopecia

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Drug clinical trials:

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Genetic Tests for Androgenetic Alopecia

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Anatomical Context for Androgenetic Alopecia

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MalaCards organs/tissues related to Androgenetic Alopecia:

32
Prostate, Skin, Heart, Testes, Thyroid, Breast, Endothelial, T cells

Animal Models for Androgenetic Alopecia or affiliated genes

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MGI Mouse Phenotypes related to Androgenetic Alopecia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.9AR, PAX1, EDA2R

Publications for Androgenetic Alopecia

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Articles related to Androgenetic Alopecia:

(show top 50)    (show all 389)
idTitleAuthorsYear
1
Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. (25254005)
2014
2
Increased androgen receptor messenger RNA in frontal-parietal hair follicles of women with androgenetic alopecia. (23479164)
2013
3
Preventive effects of Monascus on androgen-related diseases: androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer. (23651036)
2013
4
Evidence for a polygenic contribution to androgenetic alopecia. (23701444)
2013
5
Novel enzymatic assay predicts minoxidil response in the treatment of androgenetic alopecia. (24283387)
2013
6
Higher body mass index is associated with greater severity of alopecia in men with male-pattern androgenetic alopecia in Taiwan: A cross-sectional study. (24184140)
2013
7
Examining the relationship between alopecia areata, androgenetic alopecia, and emotional intelligence. (23364150)
2013
8
Partial reversal of androgenetic alopecia with methotrexate therapy for psoriasis. (24153140)
2013
9
Dermoscopic findings in female androgenetic alopecia. (23044559)
2012
10
Quality of life assessment in male patients with androgenetic alopecia: result of a prospective, multicenter study. (22879715)
2012
11
Development and characterization of phyto-vesicles of I^-sitosterol for the treatment of androgenetic alopecia. (22160579)
2012
12
Miniaturized Hairs Maintain Contact with the Arrector Pili Muscle in Alopecia Areata but not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth. (23180923)
2012
13
Re: Androgenetic alopecia as an early marker of benign prostatic hyperplasia. (23059232)
2012
14
Androgenetic alopecia in policemen: higher prevalence and different risk factors relative to the general population (KCIS no. 23). (21927906)
2011
15
Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. (21980982)
2011
16
Androgenetic alopecia and insulin resistance: are they truly associated? (21413951)
2011
17
The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia. (21224180)
2011
18
Trace elements content and hormonal profiles in women with androgenetic alopecia. (21167696)
2011
19
Evaluation of apoptosis regulatory markers in androgenetic alopecia. (21122044)
2010
20
Androgenetic alopecia and cardiovascular risk factors in men and women: a comparative study. (20619491)
2010
21
Prevalence of androgenetic alopecia in China: a community-based study in six cities. (20105167)
2010
22
Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia? (20300369)
2009
23
Evaluation of lipid levels in androgenetic alopecia in comparison with control group. (18355192)
2009
24
Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia. (17256155)
2007
25
Comparison of the efficacy and safety of topical minoxidil and topical alfatradiol in the treatment of androgenetic alopecia in women. (17451383)
2007
26
Association of androgenetic alopecia with smoking and its prevalence among Asian men: a community-based survey. (18025364)
2007
27
Expression of sex-determining genes in the scalp of men with androgenetic alopecia. (17377380)
2007
28
Premature androgenetic alopecia in adult male with nonclassic 21-OH deficiency. A novel nonsense CYP21A2 mutation (Y336X) in 2 affected siblings]. (17145028)
2006
29
Androgenetic alopecia and current methods of treatment. (15818439)
2005
30
Association of a polymorphism in the ornithine decarboxylase gene with male androgenetic alopecia. (15761444)
2005
31
Androgenetic alopecia in children: report of 20 cases. (15787828)
2005
32
Distinguishing androgenetic alopecia from chronic telogen effluvium when associated in the same patient: a simple noninvasive method. (16230561)
2005
33
Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men. (14729013)
2004
34
Androgenetic alopecia in men aged 40-69 years: prevalence and risk factors. (14674898)
2003
35
Androgenetic alopecia in a postmenopausal woman as a result of ovarian hyperthecosis. (12581085)
2003
36
An investigation of apoptosis in androgenetic alopecia. (12661906)
2003
37
Androgenetic alopecia and prostate cancer: findings from an Australian case-control study. (12050096)
2002
38
Long-term (5-year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia. (11809594)
2002
39
Androgenetic alopecia: the role of inflammation and Demodex. (11679010)
2001
40
Evaluation of sexual function in subjects taking finasteride for the treatment of androgenetic alopecia. (11763381)
2001
41
Clinical evolution of alopecia areata with a male androgenetic alopecia pattern to sisaipho. (10694313)
2000
42
Guidelines of care for androgenetic alopecia. American Academy of Dermatology. (8784287)
1996
43
DNA determination of human hair bulbs in normal and androgenetic alopecia. (7798390)
1994
44
Hormonal status in postmenopausal androgenetic alopecia. (1478763)
1992
45
The effect of cyproterone acetate on hair roots and hair shaft diameter in androgenetic alopecia in females. (2572103)
1989
46
Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp. (3214820)
1988
47
Androgenetic alopecia treated with topical minoxidil. (3549800)
1987
48
Treatment of female androgenetic alopecia with cimetidine. (3570585)
1987
49
Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. (921894)
1977
50
Testosterone metabolism in the skin. A review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens. (128323)
1975

Variations for Androgenetic Alopecia

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Expression for genes affiliated with Androgenetic Alopecia

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Expression patterns in normal tissues for genes affiliated with Androgenetic Alopecia

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Pathways for genes affiliated with Androgenetic Alopecia

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Pathways related to Androgenetic Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1AR, WNT10A
2
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1AR, WNT10A

Compounds for genes affiliated with Androgenetic Alopecia

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GO Terms for genes affiliated with Androgenetic Alopecia

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Biological processes related to Androgenetic Alopecia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell proliferationGO:0082839.3AR, PAX1
2positive regulation of NF-kappaB transcription factor activityGO:0510929.2AR, EDA2R

Products for genes affiliated with Androgenetic Alopecia

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Sources for Androgenetic Alopecia

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3CDC
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